![](database/fig/treefig/space.png) | ![](database/fig/treefig/horap.png) | PP1_PSD |
Enter a Search String | Special character and space not allowed in the query term.
Search string should be at least 2 characters long. |
Reaction List for pathway PP2B (Pathway Number 276) | Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered. |   | Name | Kf | Kb | Kd | tau | Substrate | Product | 1 |
Ca-bind-CaNAB | kf (uM^-2 s^-1) | 1 (s^-1) | Kd(af) = 0.01(uM) | - | CaNAB Ca Ca
| CaNAB-Ca2
| | going on the experience with CaM, we put the fast (high affinity) sites first. We only know (Stemmer and Klee) that the affinity is < 70 nM. Assuming 10 nM at first, we get kf = 2.78e-8, kb = 1. Try 20 nM. kf = 7e-9, kb = 1 | 2 |
Ca-bind-CaNAB-Ca 2 | kf (uM^-2 s^-1) | 1 (s^-1) | Kd(af) = 0.527(uM) | - | Ca Ca CaNAB-Ca2
| CaNAB-Ca4
| | This process is probably much more complicated and involves CaM. However, as I can't find detailed info I am bundling this into a single step. Based on Steemer and Klee pg 6863, the Kact is 0.5 uM. kf/kb = 1/(0.5 * 6e5)^2 = 1.11e-11 | 3 |
CaMCa4-bind-CaNA B | kf (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.0017(uM) | - | CaM-Ca4 CaNAB-Ca4
| CaM_Ca_n-CaNAB
|
Pathway Details Molecule List Enzyme List Reaction List
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
|