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Accession Type:
Network
RanGTPase
Shared_Object_
RanGTPase
Nucleus
 Molecule
 Reaction
Cytoplasm

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Reaction List for pathway Nucleus (Pathway Number 305)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.
  Name KfKbKdtauSubstrateProduct
1 GDP_
dissociation		kf
(s^-1)		11
(uM^-1 s^-1)		Kd(cb) = 0.5238(uM)-RCC1-GDP.Ran
RCC1-Ran
GDP
  Release of GDP from the GDP-Ran complex with RCC1 Kf = 21 /sec Kb = 1.1e+07 /M/sec = 1.1e+01 /uM/sec Christian Klebe et al (1995) Biochemistry 34:12543-12552. Supplementary Table A Gorlich D et al (2003) EMBO J 22(5):1088-1100
2 GTP.Ran_releasekf
(s^-1)		99.9994
(uM^-1 s^-1)		Kd(cb) = 1.8182(uM)-RCC1-RanGTP
GTP.Ran-nuclear
RCC1
  Release of GTP.Ran from GTP.Ran-RCC1 complex Kf = 55 /sec Kb = 1.0e+08 /M/sec = 1.0e+02 /uM/sec Christian Klebe et al (1995) Biochemistry 34:12543-12552. Supplementary Table A Gorlich D et al (2003) EMBO J 22(5):1088-1100
3 GTP_bindingkf
(uM^-1 s^-1)		19
(s^-1)		Kd(bf) = 31.6669(uM)-RCC1-Ran
GTP
RCC1-RanGTP
  Binding of GTP to GDP free Ran-RCC1 complex Kf = 0.6e+06 /M/sec = 0.6 /uM/sec Kb = 19 /sec Christian Klebe et al (1995) Biochemistry 34:12543-12552. Supplementary Table A Gorlich D et al (2003) EMBO J 22(5):1088-1100
4 NTF2_
dissociation[1]		kf
(s^-1)		0
(#^-1 s^-1)		Not applicable**-
  • nuclear-NTF2-GDP
    .Ran
    		• GDP.Ran-nuclear
    NTF2
      Approximation of reaction rates to match the kinetics described by Gorlich D et al (2003) EMBO J 22(5):1088-1100
    5 RCC1_bindingkf
    (uM^-1 s^-1)    		55
    (s^-1)    		Kd(bf) = 0.7432(uM)-GDP.Ran-nuclear
    RCC1
    		RCC1-GDP.Ran
      Binding of GDP-Ran complex with RCC1 Kf = 7.4e+07 /M/sec = 7.4e+01 /uM/sec Kb = 55 /sec Christian Klebe et al (1995) Biochemistry 34:12543-12552. Supplementary Table A Gorlich D et al (2003) EMBO J 22(5):1088-1100


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