|
Enter a Search String | | Special character and space not allowed in the query term.
Search string should be at least 2 characters long. |
Molecule Parameter List for JAK | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| JAK participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 0 | 0 | 0 | 0 | 2 | 0 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | SOCS1_knockout | 67 | Pathway |
SOCS1_knockout | This model was taken from the Yamada S et al. FEBS Letters 2003 Jan 16;534(1-3):190-6
This model shows the control mechanism of Jak-Stat pathway, here SOCS1 (Suppressor of cytokine signaling-I) was identified as the negative regulator of Jak and STAT signal transduction pathway. This is the knockout version of Jak-Stat pathway in this model the SOCS1 has been knocked out i.e it formation is not shown.
The graphs are almost similar to the graphs as shown in the paper but STAT1n graph has some ambiguities. Thanks to Dr Satoshi Yamada for clarifying some of those ambiguities and providing the values used in the simulations. |
JAK acting as a Molecule in SOCS1_knockout Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | JAK | SOCS1_knockout
Accession No. : 67 | SOCS1_knockout
Pathway No. : 294 | 0.02 | 0.0016667 | No | | JAK: Janus Kinase JAK = 20 nM = 0.02 uM Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
JAK acting as a Substrate in a reaction in SOCS1_knockout Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | JAK_binding | SOCS1_knockout
Accession No. : 67 | SOCS1_knockout
Pathway No. : 294 | 100
(uM^-1 s^-1) | 0.05
(s^-1) | Kd(bf) = 0.0005(uM) | - | Substrate
JAK
R
Product
RJ
| | | Binding of JAK to the intracellular domain of the IFN gamma receptor Kf = 100*10e+06 /M/sec = 100/uM/sec Kb = 0.05 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 | | 2 | IFNR-JAK_bind | SOCS1_knockout
Accession No. : 67 | SOCS1_knockout
Pathway No. : 294 | 100
(uM^-1 s^-1) | 0.05
(s^-1) | Kd(bf) = 0.0005(uM) | - | Substrate
IFNR
JAK
Product
IFNRJ_
| | | Binding reaction of IFNR + JAK kf = 100/sec/uM kb = 0.05/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
|
