// DOQCS : http://doqcs.ncbs.res.in/ // Accession Name = fig2_egfr // Accession Number = 1 // Transcriber = Upinder S. Bhalla, NCBS // Developer = Upinder S. Bhalla, NCBS // Species = Generic mammalian // Tissue = Brain // Cell Compartment = Surface - Nucleus // Notes = This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse.
Demonstration script files for generating the figures in the paper, including figure 2, are available here. //genesis // kkit Version 11 flat dumpfile // Saved on Thu Dec 8 12:33:56 2005 include kkit {argv 1} FASTDT = 0.005 SIMDT = 0.005 CONTROLDT = 1 PLOTDT = 1 MAXTIME = 1000 TRANSIENT_TIME = 2 VARIABLE_DT_FLAG = 0 DEFAULT_VOL = 1.6667e-21 VERSION = 11.0 setfield /file/modpath value /home2/bhalla/scripts/modules kparms //genesis initdump -version 3 -ignoreorphans 1 simobjdump doqcsinfo filename accessname accesstype transcriber developer \ citation species tissue cellcompartment methodology sources \ model_implementation model_validation x y z simobjdump table input output alloced step_mode stepsize x y z simobjdump xtree path script namemode sizescale simobjdump xcoredraw xmin xmax ymin ymax simobjdump xtext editable simobjdump xgraph xmin xmax ymin ymax overlay simobjdump xplot pixflags script fg ysquish do_slope wy simobjdump group xtree_fg_req xtree_textfg_req plotfield expanded movealone \ link savename file version md5sum mod_save_flag x y z simobjdump geometry size dim shape outside xtree_fg_req xtree_textfg_req x y \ z simobjdump kpool DiffConst CoInit Co n nInit mwt nMin vol slave_enable \ geomname xtree_fg_req xtree_textfg_req x y z simobjdump kreac kf kb notes xtree_fg_req xtree_textfg_req x y z simobjdump kenz CoComplexInit CoComplex nComplexInit nComplex vol k1 k2 k3 \ keepconc usecomplex notes xtree_fg_req xtree_textfg_req link x y z simobjdump stim level1 width1 delay1 level2 width2 delay2 baselevel trig_time \ trig_mode notes xtree_fg_req xtree_textfg_req is_running x y z simobjdump xtab input output alloced step_mode stepsize notes editfunc \ xtree_fg_req xtree_textfg_req baselevel last_x last_y is_running x y z simobjdump kchan perm gmax Vm is_active use_nernst notes xtree_fg_req \ xtree_textfg_req x y z simobjdump transport input output alloced step_mode stepsize dt delay clock \ kf xtree_fg_req xtree_textfg_req x y z simobjdump proto x y z simundump geometry /kinetics/geometry 0 1e-15 3 sphere "" white black 41 86 0 simundump geometry /kinetics/geometry[1] 0 1.6667e-21 3 sphere "" white black \ 0 0 0 simundump geometry /kinetics/geometry[2] 0 1.6e-16 3 sphere "" white black 19 \ 42 0 simundump geometry /kinetics/geometry[3] 0 1e-13 3 sphere "" white black 19 \ 42 0 simundump geometry /kinetics/geometry[4] 0 1e-15 3 sphere "" white black 19 \ 42 0 simundump geometry /kinetics/geometry[5] 0 1.6e-16 3 sphere "" white black 19 \ 42 0 simundump geometry /kinetics/geometry[6] 0 1e-13 3 sphere "" white black 19 \ 42 0 simundump group /kinetics/PKC 0 blue black x 0 0 "" defaultfile defaultfile.g \ 0 0 0 15.951 50.216 0 simundump kpool /kinetics/PKC/PKC-Ca 0 0 3.7208e-17 3.7208e-17 2.2325e-11 \ 2.2325e-11 0 0 6e+05 0 /kinetics/geometry[4] red black 14.925 43.511 0 simundump kreac /kinetics/PKC/PKC-act-by-Ca 0 1e-06 0.5 "" white blue 14.925 \ 41.877 0 simundump kreac /kinetics/PKC/PKC-act-by-DAG 0 1.3333e-08 8.6348 "" white \ blue 16.939 42.694 0 simundump kreac /kinetics/PKC/PKC-Ca-to-memb 0 1.2705 3.5026 "" white blue \ 15.203 46.253 0 simundump kreac /kinetics/PKC/PKC-DAG-to-memb 0 1 0.1 "" white blue 16.383 \ 44.736 0 simundump kreac /kinetics/PKC/PKC-act-by-Ca-AA 0 2e-09 0.1 "" white blue \ 18.212 45.816 0 simundump kreac /kinetics/PKC/PKC-act-by-DAG-AA 0 2 0.2 "" white blue 20.249 \ 45.232 0 simundump kpool /kinetics/PKC/PKC-DAG-AA* 0 0 4.9137e-18 4.9137e-18 \ 2.9482e-12 2.9482e-12 0 0 6e+05 0 /kinetics/geometry[4] cyan blue 19.601 \ 47.537 0 simundump kpool /kinetics/PKC/PKC-Ca-AA* 0 0 1.75e-16 1.75e-16 1.05e-10 \ 1.05e-10 0 0 6e+05 0 /kinetics/geometry[4] orange blue 18.397 48.296 0 simundump kpool /kinetics/PKC/PKC-Ca-memb* 0 0 1.3896e-17 1.3896e-17 \ 8.3376e-12 8.3376e-12 0 0 6e+05 0 /kinetics/geometry[4] pink blue 16.221 \ 48.529 0 simundump kpool /kinetics/PKC/PKC-DAG-memb* 0 0 9.4352e-21 9.4352e-21 \ 5.6611e-15 5.6611e-15 0 0 6e+05 0 /kinetics/geometry[4] yellow blue 17.17 \ 47.508 0 simundump kpool /kinetics/PKC/PKC-basal* 0 0 0.02 0.02 12000 12000 0 0 6e+05 \ 0 /kinetics/geometry[4] pink blue 14.253 47.566 0 simundump kreac /kinetics/PKC/PKC-basal-act 0 1 50 "" white blue 14.022 \ 45.057 0 simundump kpool /kinetics/PKC/PKC-AA* 0 0 1.8133e-17 1.8133e-17 1.088e-11 \ 1.088e-11 0 0 6e+05 0 /kinetics/geometry[4] cyan blue 20.782 48.821 0 simundump kreac /kinetics/PKC/PKC-act-by-AA 0 2e-10 0.1 "" white blue 14.007 \ 40.135 0 simundump kpool /kinetics/PKC/PKC-Ca-DAG 0 0 8.4632e-23 8.4632e-23 5.0779e-17 \ 5.0779e-17 0 0 6e+05 0 /kinetics/geometry[4] white blue 19.231 43.803 0 simundump kreac /kinetics/PKC/PKC-n-DAG 0 1e-09 0.1 "" white blue 15.99 40.01 \ 0 simundump kpool /kinetics/PKC/PKC-DAG 0 0 1.161e-16 1.161e-16 6.9661e-11 \ 6.9661e-11 0 0 6e+05 0 /kinetics/geometry[4] white blue 18.004 40.914 0 simundump kreac /kinetics/PKC/PKC-n-DAG-AA 0 3e-08 2 "" white blue 17.772 \ 39.047 0 simundump kpool /kinetics/PKC/PKC-DAG-AA 0 0 2.5188e-19 2.5188e-19 1.5113e-13 \ 1.5113e-13 0 0 6e+05 0 /kinetics/geometry[4] white blue 19.624 42.227 0 simundump kpool /kinetics/PKC/PKC-cytosolic 0 0 1 1 6e+05 6e+05 0 0 6e+05 0 \ /kinetics/geometry[4] white blue 12.868 42.597 0 simundump kpool /kinetics/DAG 1 0 0 0 0 0 0 0 6e+05 0 /kinetics/geometry[4] \ green black 19.718 34.438 0 simundump kpool /kinetics/Ca 1 0 0.08 0.08 48000 48000 0 0 6e+05 0 \ /kinetics/geometry[4] red black 10.613 39.237 0 simundump kpool /kinetics/AA 0 0 0 0 0 0 0 0 6e+05 0 /kinetics/geometry[4] \ darkgreen black 15.71 32.662 0 simundump kpool /kinetics/PKC-active 0 0 2.1222e-16 0.02 12000 12000 0 0 \ 6e+05 2 /kinetics/geometry[4] yellow black 21.132 50.477 0 simundump kenz /kinetics/PKC-active/PKC-act-raf 1 0 0 0 0 6e+05 5e-07 16 4 0 \ 0 "" red yellow "" 25.253 52.549 0 simundump kenz /kinetics/PKC-active/PKC-inact-GAP 1 0 0 0 0 1 1e-05 16 4 0 0 \ "" red yellow "" 22.439 53.804 0 simundump kenz /kinetics/PKC-active/PKC-act-GEF 1 0 0 0 0 1 1e-05 16 4 0 0 "" \ red yellow "" 18.752 59.264 0 simundump group 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simundump kpool /kinetics/PLA2/PIP2-Ca-PLA2* 0 0 0 0 0 0 0 0 6e+05 0 \ /kinetics/geometry[4] cyan darkgreen 10.674 34.104 0 simundump kenz /kinetics/PLA2/PIP2-Ca-PLA2*/kenz 0 0 0 0 0 6e+05 1.5e-05 144 \ 36 0 0 "" red cyan "" 13.028 34.021 0 simundump kreac /kinetics/PLA2/DAG-Ca-PLA2-act 0 5e-09 4 "" white darkgreen \ 8.174 32.166 0 simundump kpool /kinetics/PLA2/DAG-Ca-PLA2* 0 0 0 0 0 0 0 0 6e+05 0 \ /kinetics/geometry[4] pink darkgreen 10.861 31.521 0 simundump kenz /kinetics/PLA2/DAG-Ca-PLA2*/kenz 0 0 0 0 0 6e+05 2.5e-05 240 \ 60 0 0 "" red pink "" 13.049 31.646 0 simundump kpool /kinetics/PLA2/APC 0 0 30 30 1.8e+07 1.8e+07 0 0 6e+05 5 \ /kinetics/geometry[4] yellow darkgreen 10.761 32.037 0 simundump kreac /kinetics/PLA2/Degrade-AA 1 0.4 0 "" white darkgreen 12.819 \ 36.713 0 simundump kpool /kinetics/PLA2/PLA2*-Ca 0 0 0 0 0 0 0 0 6e+05 1 \ /kinetics/geometry[4] orange darkgreen 11.187 29.313 0 simundump kenz /kinetics/PLA2/PLA2*-Ca/kenz 0 0 0 0 0 6e+05 5e-05 480 120 0 0 \ "" red orange "" 12.919 29.183 0 simundump kpool /kinetics/PLA2/PLA2* 1 0 0 0 0 0 0 0 6e+05 0 \ /kinetics/geometry[4] orange darkgreen 9.975 27.149 0 simundump kreac /kinetics/PLA2/PLA2*-Ca-act 1 1e-05 0.1 "" white darkgreen \ 8.914 29.248 0 simundump kreac /kinetics/PLA2/dephosphorylate-PLA2* 1 0.17 0 "" white \ darkgreen 5.307 30.265 0 simundump kpool /kinetics/MAPK* 1 0 0 0 0 0 0 0 6e+05 0 /kinetics/geometry[4] \ orange yellow 36.453 30.015 0 simundump kenz /kinetics/MAPK*/MAPK* 0 0 0 0 0 6e+05 6.5e-06 80 20 0 0 "" red \ orange "" 6.995 27.06 0 simundump kenz /kinetics/MAPK*/MAPK*-feedback 1 0 0 0 0 6e+05 3.25e-06 40 10 \ 0 0 "" red orange "" 29.387 52.668 0 simundump kenz /kinetics/MAPK*/phosph_Sos 1 0 0 0 0 6e+05 3.25e-05 40 10 0 0 \ "" red orange "" 37.458 82.13 0 simundump kpool /kinetics/temp-PIP2 1 0 2.5 2.5 1.5e+06 1.5e+06 0 0 6e+05 6 \ /kinetics/geometry[4] green black 3.204 34.953 0 simundump kpool /kinetics/IP3 1 0 0 0 0 0 0 0 6e+05 0 /kinetics/geometry[4] \ pink black 18.226 37.345 0 simundump kpool /kinetics/Glu 1 0 0 0 0 0 0 0 6e+05 0 /kinetics/geometry[4] \ green black 18.338 55.305 0 simundump group /kinetics/PLCbeta 1 maroon black x 0 0 "" defaultfile \ defaultfile.g 0 0 0 27.585 24.532 0 simundump kreac /kinetics/PLCbeta/Act-PLC-Ca 1 5e-06 1 "" white maroon 22.071 \ 25.022 0 simundump kpool /kinetics/PLCbeta/PLC 1 0 0.8 0.8 4.8e+05 4.8e+05 0 0 6e+05 0 \ /kinetics/geometry[4] cyan maroon 29.697 25.043 0 simundump kreac /kinetics/PLCbeta/Degrade-IP3 1 2.5 0 "" white maroon 21.312 \ 34.029 0 simundump kpool /kinetics/PLCbeta/Inositol 1 0 0 0 0 0 0 0 6e+05 4 \ /kinetics/geometry[4] green maroon 23.965 33.258 0 simundump kreac /kinetics/PLCbeta/Degrade-DAG 1 0.15 0 "" white maroon 18.043 \ 34.739 0 simundump kpool /kinetics/PLCbeta/PC 1 0 0 0 0 0 0 0 1 4 /kinetics/geometry \ green maroon 23.904 34.862 0 simundump kpool /kinetics/PLCbeta/PLC-Ca 1 0 0 0 0 0 0 0 6e+05 0 \ /kinetics/geometry[4] cyan maroon 26.015 29.203 0 simundump kenz /kinetics/PLCbeta/PLC-Ca/PLC-Ca 1 0 0 0 0 6e+05 4.2e-06 40 10 \ 0 0 "" red cyan "" 16.749 30.303 0 simundump kreac /kinetics/PLCbeta/Act-PLC-by-Gq 1 4.2e-05 1 "" white maroon \ 21.7 26.837 0 simundump kreac /kinetics/PLCbeta/Inact-PLC-Gq 1 0.0133 0 "" white maroon \ 30.125 31.686 0 simundump kpool /kinetics/PLCbeta/PLC-Ca-Gq 0 0 0 0 0 0 0 0 6e+05 0 \ /kinetics/geometry[4] cyan maroon 29.629 28.589 0 simundump kenz /kinetics/PLCbeta/PLC-Ca-Gq/PLCb-Ca-Gq 0 0 0 0 0 6e+05 8e-05 \ 192 48 0 0 "" red cyan "" 21.947 30.922 0 simundump kpool /kinetics/PLCbeta/PLC-Gq 1 0 0 0 0 0 0 0 6e+05 0 \ /kinetics/geometry[4] cyan maroon 34.035 28.463 0 simundump kreac /kinetics/PLCbeta/PLC-bind-Gq 1 4.2e-06 1 "" white maroon \ 33.746 25.737 0 simundump kreac /kinetics/PLCbeta/PLC-Gq-bind-Ca 1 5e-05 1 "" white maroon \ 33.004 30.746 0 simundump kpool /kinetics/PIP2 1 0 10 10 6e+06 6e+06 0 0 6e+05 4 \ /kinetics/geometry[4] green black 22.884 35.278 0 simundump kpool /kinetics/BetaGamma 1 0 0 0 0 0 0 0 6e+05 0 \ /kinetics/geometry[4] yellow black 34.787 39.384 0 simundump kpool /kinetics/G*GTP 1 0 0 0 0 0 0 0 6e+05 0 /kinetics/geometry[4] \ red black 26.315 34.987 0 simundump kpool /kinetics/G*GDP 1 0 0 0 0 0 0 0 6e+05 0 /kinetics/geometry[4] \ yellow black 32.56 36.347 0 simundump group /kinetics/Gq 1 blue black x 0 0 "" defaultfile defaultfile.g \ 0 0 0 31.745 40.056 0 simundump kreac /kinetics/Gq/RecLigandBinding 1 2.8e-05 10 "" white blue \ 26.339 38.821 0 simundump kpool /kinetics/Gq/G-GDP 1 0 1 1 6e+05 6e+05 0 0 6e+05 0 \ /kinetics/geometry[4] yellow blue 29.68 39.427 0 simundump kreac /kinetics/Gq/Basal-Act-G 1 1e-04 0 "" white blue 28.805 \ 37.177 0 simundump kreac /kinetics/Gq/Trimerize-G 1 1e-05 0 "" white blue 31.255 \ 37.217 0 simundump kreac /kinetics/Gq/Inact-G 1 0.0133 0 "" white blue 29.218 34.39 0 simundump kpool /kinetics/Gq/mGluR 1 0 0.3 0.3 1.8e+05 1.8e+05 0 0 6e+05 0 \ /kinetics/geometry[4] green blue 25.464 40.238 0 simundump kpool /kinetics/Gq/Rec-Glu 1 0 0 0 0 0 0 0 6e+05 0 \ /kinetics/geometry[4] green blue 24.811 38.278 0 simundump kpool /kinetics/Gq/Rec-Gq 1 0 0 0 0 0 0 0 6e+05 0 \ /kinetics/geometry[4] green blue 23.077 41.001 0 simundump kreac /kinetics/Gq/Rec-Glu-bind-Gq 1 1e-08 1e-04 "" white blue \ 23.715 39.577 0 simundump kreac /kinetics/Gq/Glu-bind-Rec-Gq 1 2.8e-05 0.1 "" white blue \ 21.386 38.963 0 simundump kpool /kinetics/Gq/Rec-Glu-Gq 1 0 0 0 0 0 0 0 6e+05 0 \ /kinetics/geometry[4] orange blue 23.742 36.883 0 simundump kreac /kinetics/Gq/Activate-Gq 1 0.01 0 "" white blue 26.017 37.343 \ 0 simundump kreac /kinetics/Gq/Rec-bind-Gq 1 1e-06 1 "" white blue 25.743 \ 41.911 0 simundump kpool /kinetics/Gq/mGluRAntag 1 0 0 0 0 0 0 0 6e+05 4 \ /kinetics/geometry[4] seagreen blue 19.602 39.691 0 simundump kreac /kinetics/Gq/Antag-bind-Rec-Gq 1 1e-04 0.01 "" white blue \ 21.14 37.719 0 simundump kpool /kinetics/Gq/Blocked-rec-Gq 1 0 0 0 0 0 0 0 6e+05 0 \ /kinetics/geometry[4] seagreen blue 21.46 36.019 0 simundump group /kinetics/MAPK 0 brown black x 0 0 "" defaultfile \ defaultfile.g 0 0 0 33.616 53.191 0 simundump kpool /kinetics/MAPK/craf-1 0 0 0.2 0.2 1.2e+05 1.2e+05 0 0 6e+05 0 \ /kinetics/geometry[4] pink brown 25.326 50.117 0 simundump kpool /kinetics/MAPK/craf-1* 0 0 0 0 0 0 0 0 6e+05 0 \ /kinetics/geometry[4] pink brown 28.24 49.712 0 simundump kpool /kinetics/MAPK/MAPKK 0 0 0.18 0.18 1.08e+05 1.08e+05 0 0 \ 6e+05 0 /kinetics/geometry[4] pink brown 25.332 45.989 0 simundump kpool /kinetics/MAPK/MAPK 0 0 0.36 0.36 2.16e+05 2.16e+05 0 0 6e+05 \ 0 /kinetics/geometry[4] pink brown 25.066 43.086 0 simundump kpool /kinetics/MAPK/craf-1** 1 0 0 0 0 0 0 0 6e+05 0 \ /kinetics/geometry[4] hotpink brown 31.464 49.902 0 simundump kpool /kinetics/MAPK/MAPK-tyr 1 0 0 0 0 0 0 0 6e+05 0 \ /kinetics/geometry[4] orange brown 27.415 42.82 0 simundump kpool /kinetics/MAPK/MAPKK* 0 0 0 0 0 0 0 0 6e+05 0 \ /kinetics/geometry[4] pink brown 31.548 46.026 0 simundump kenz /kinetics/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 6e+05 2.7e-05 0.6 \ 0.15 0 0 "" red pink "" 27.891 45.553 0 simundump kenz /kinetics/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 6e+05 2.7e-05 0.6 \ 0.15 0 0 "" red pink "" 31.961 45.036 0 simundump kpool /kinetics/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 6e+05 0 \ /kinetics/geometry[4] pink brown 28.265 46.166 0 simundump kpool /kinetics/MAPK/Raf-GTP-Ras* 1 0 0 0 0 0 0 0 6e+05 0 \ /kinetics/geometry[4] red brown 23.905 48.781 0 simundump kenz /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.1 1 0 0 0 0 1 5.5e-06 \ 0.42 0.105 0 0 "" red red "" 26.618 48.219 0 simundump kenz /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.2 1 0 0 0 0 1 5.5e-06 \ 0.42 0.105 0 0 "" red red "" 29.698 48.069 0 simundump kpool /kinetics/MKP-1 1 0 0.0032 0.0032 1920 1920 0 0 6e+05 0 \ /kinetics/geometry[4] hotpink black 24.082 44.441 0 simundump kenz /kinetics/MKP-1/MKP1-tyr-deph 1 0 0 0 0 6e+05 0.000125 4 1 0 0 \ "" red hotpink "" 25.278 45.068 0 simundump kenz /kinetics/MKP-1/MKP1-thr-deph 1 0 0 0 0 6e+05 0.000125 4 1 0 0 \ "" red hotpink "" 29.789 44.931 0 simundump kreac /kinetics/Ras-act-craf 1 4e-05 0.5 "" white black 22.561 \ 52.091 0 simundump kpool /kinetics/PPhosphatase2A 1 0 0.224 0.224 1.344e+05 1.344e+05 \ 0 0 6e+05 0 /kinetics/geometry[4] hotpink yellow 28.39 51.131 0 simundump kenz /kinetics/PPhosphatase2A/craf-deph 1 0 0 0 0 6e+05 3.3e-06 25 \ 6 0 0 "" red hotpink "" 26.801 52.215 0 simundump kenz /kinetics/PPhosphatase2A/MAPKK-deph 1 0 0 0 0 6e+05 3.3e-06 25 \ 6 0 0 "" red hotpink "" 32.159 48.074 0 simundump kenz /kinetics/PPhosphatase2A/MAPKK-deph-ser 1 0 0 0 0 6e+05 \ 3.3e-06 25 6 0 0 "" red hotpink "" 23.865 47.921 0 simundump kenz /kinetics/PPhosphatase2A/craf**-deph 1 0 0 0 0 1 3.3e-06 25 6 \ 0 0 "" red hotpink "" 31.446 51.905 0 simundump group /kinetics/Ras 1 blue black x 0 0 "" defaultfile defaultfile.g \ 0 0 0 33.513 58.351 0 simundump kreac /kinetics/Ras/bg-act-GEF 1 1e-05 1 "" white blue 32.468 \ 56.838 0 simundump kpool /kinetics/Ras/GEF-Gprot-bg 1 0 0 0 0 0 0 0 6e+05 0 \ /kinetics/geometry[4] hotpink blue 29.373 59.271 0 simundump kenz /kinetics/Ras/GEF-Gprot-bg/GEF-bg_act-ras 1 0 0 0 0 6e+05 \ 3.3e-07 0.08 0.02 0 0 "" red hotpink "" 29.402 58.523 0 simundump kreac /kinetics/Ras/dephosph-GEF 1 1 0 "" white blue 28.07 59.881 0 simundump kpool /kinetics/Ras/inact-GEF 1 0 0.1 0.1 60000 60000 0 0 6e+05 0 \ /kinetics/geometry[4] hotpink blue 31.453 60.352 0 simundump kpool /kinetics/Ras/GEF* 1 0 0 0 0 0 0 0 6e+05 0 \ /kinetics/geometry[4] hotpink blue 25.448 59.246 0 simundump kenz /kinetics/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 6e+05 3.3e-07 0.08 \ 0.02 0 0 "" red hotpink "" 26.085 58.086 0 simundump kpool /kinetics/Ras/GTP-Ras 1 0 0 0 0 0 0 0 6e+05 0 \ /kinetics/geometry[4] orange blue 31.564 55.084 0 simundump kpool /kinetics/Ras/GDP-Ras 1 0 0.2 0.2 1.2e+05 1.2e+05 0 0 6e+05 0 \ /kinetics/geometry[4] pink blue 25.131 56.165 0 simundump kreac /kinetics/Ras/Ras-intrinsic-GTPase 1 1e-04 0 "" white blue \ 28.098 55.5 0 simundump kreac /kinetics/Ras/dephosph-GAP 1 0.1 0 "" white blue 23.023 \ 57.524 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/kinetics/geometry[4] hotpink darkgreen 7.02 \ 71.228 0 simundump kchan /kinetics/CaRegulation/Ca-leak-from-extracell/Ca-leak-chan 1 \ 0.004 0.1 0 1 0 "" brown hotpink 8.331 69.411 0 simundump kpool /kinetics/CaRegulation/capacitive_Ca_entry* 1 0 0.00083333 \ 0.00083333 500 500 0 0 6e+05 0 /kinetics/geometry[4] hotpink darkgreen \ 3.209 69.52 0 simundump kchan /kinetics/CaRegulation/capacitive_Ca_entry*/Cap_entry_chan 1 \ 0.005 0.1 0 1 0 "" brown hotpink 6.365 69.303 0 simundump kreac /kinetics/CaRegulation/inactivate_cap_Ca 1 1.2e-11 1 "" white \ darkgreen 3.328 67.27 0 simundump kpool /kinetics/CaRegulation/inact_cap_entry 1 0 0 0 0 0 0 0 6e+05 \ 0 /kinetics/geometry[4] pink darkgreen 3.119 64.314 0 simundump doqcsinfo /kinetics/doqcsinfo 0 db1.g fig2_egfr network \ "Upinder S. Bhalla, NCBS" "Upinder S. Bhalla, NCBS" "citation here" \ "Generic Mammalian" Brain "Surface - Nucleus" \ "Quantitative match to experiments, Hypothetical" \ "Bhalla US and Iyengar R. Science (1999) 283(5400):381-7(Peer-reviewed publication ), Peer-reviewed publication, Peer-reviewed publication" \ "Exact GENESIS implementation" \ "Approximates original data , Quantitatively predicts new data" 41 89 0 simundump xgraph /graphs/conc1 0 0 10000 0 0.007 0 simundump xgraph /graphs/conc2 0 0 10000 0 0.1 0 simundump xplot /graphs/conc1/MAPK*.Co 3 524288 \ "delete_plot.w ; edit_plot.D " orange 0 0 1 simundump xplot /graphs/conc1/PKC-active.Co 3 524288 \ "delete_plot.w ; edit_plot.D " yellow 0 0 1 simundump xplot /graphs/conc2/EGF.Co 3 524288 \ "delete_plot.w ; edit_plot.D " red 0 0 1 simundump xplot /graphs/conc2/EGFR.Co 3 524288 \ "delete_plot.w ; edit_plot.D " red 0 0 1 simundump xplot /graphs/conc2/Ca.PLC_g*.Co 3 524288 \ "delete_plot.w ; edit_plot.D " pink 0 0 1 simundump xplot /graphs/conc2/Ca.PLC_g.Co 3 524288 \ "delete_plot.w ; edit_plot.D " pink 0 0 1 simundump xplot /graphs/conc2/SHC*.Co 3 524288 \ "delete_plot.w ; edit_plot.D " orange 0 0 1 simundump xgraph /moregraphs/conc3 0 0 10000 0.0020844 0.1 0 simundump xgraph /moregraphs/conc4 0 143.8 10000 -0.067568 20 0 simundump xplot /moregraphs/conc3/Sos.Co 3 524288 \ "delete_plot.w ; edit_plot.D " red 0 0 1 simundump xplot /moregraphs/conc3/Sos.Grb2.Co 3 524288 \ "delete_plot.w ; edit_plot.D " orange 0 0 1 simundump xplot /moregraphs/conc3/Shc*.Sos.Grb2.Co 3 524288 \ "delete_plot.w ; edit_plot.D " brown 0 0 1 simundump xplot /moregraphs/conc4/IP3.Co 3 524288 \ "delete_plot.w ; edit_plot.D " pink 0 0 1 simundump xplot /moregraphs/conc4/DAG.Co 3 524288 \ "delete_plot.w ; edit_plot.D " green 0 0 1 simundump xcoredraw /edit/draw 0 -2 43 -2 91 simundump xtree /edit/draw/tree 0 \ /kinetics/#[],/kinetics/#[]/#[],/kinetics/#[]/#[]/#[][TYPE!=proto],/kinetics/#[]/#[]/#[][TYPE!=linkinfo]/##[] \ "edit_elm.D ; drag_from_edit.w " auto 0.6 simundump xtext /file/notes 0 1 xtextload /file/notes \ "Merged:" \ "PKC45, PLA50, PLC_Gq61, MAPK77," \ "ras8, simple_egf424" \ "and added enz reac for Sos.Ras_GEF" \ "on GDP ras giving GTP-ras." \ "Added some plots on top." \ "Eliminated notes for portability." addmsg /kinetics/PKC/PKC-act-by-Ca /kinetics/PKC/PKC-Ca REAC B A addmsg /kinetics/PKC/PKC-act-by-DAG /kinetics/PKC/PKC-Ca REAC A B addmsg /kinetics/PKC/PKC-Ca-to-memb /kinetics/PKC/PKC-Ca REAC A B addmsg /kinetics/PKC/PKC-act-by-Ca-AA /kinetics/PKC/PKC-Ca REAC A B addmsg /kinetics/PKC/PKC-cytosolic /kinetics/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/Ca /kinetics/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/DAG /kinetics/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/PKC/PKC-Ca-DAG /kinetics/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/PKC/PKC-Ca-memb* /kinetics/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/PKC/PKC-Ca-DAG /kinetics/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/PKC/PKC-DAG-memb* /kinetics/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/AA /kinetics/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/PKC/PKC-Ca-AA* /kinetics/PKC/PKC-act-by-Ca-AA PRODUCT n addmsg /kinetics/PKC/PKC-DAG-AA* /kinetics/PKC/PKC-act-by-DAG-AA PRODUCT n addmsg /kinetics/PKC/PKC-DAG-AA /kinetics/PKC/PKC-act-by-DAG-AA SUBSTRATE n addmsg /kinetics/PKC/PKC-act-by-DAG-AA /kinetics/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/PKC/PKC-act-by-Ca-AA /kinetics/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/PKC/PKC-Ca-to-memb /kinetics/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/PKC/PKC-DAG-to-memb /kinetics/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/PKC/PKC-basal-act /kinetics/PKC/PKC-basal* REAC B A addmsg /kinetics/PKC/PKC-cytosolic /kinetics/PKC/PKC-basal-act SUBSTRATE n addmsg /kinetics/PKC/PKC-basal* /kinetics/PKC/PKC-basal-act PRODUCT n addmsg /kinetics/PKC/PKC-act-by-AA /kinetics/PKC/PKC-AA* REAC B A addmsg /kinetics/AA /kinetics/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/PKC/PKC-AA* /kinetics/PKC/PKC-act-by-AA PRODUCT n addmsg /kinetics/PKC/PKC-cytosolic /kinetics/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/PKC/PKC-act-by-DAG /kinetics/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/PKC/PKC-DAG-to-memb /kinetics/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/PKC/PKC-cytosolic /kinetics/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/DAG /kinetics/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/PKC/PKC-DAG /kinetics/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/PKC/PKC-n-DAG /kinetics/PKC/PKC-DAG REAC B A addmsg /kinetics/PKC/PKC-n-DAG-AA /kinetics/PKC/PKC-DAG REAC A B addmsg /kinetics/PKC/PKC-DAG /kinetics/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/AA /kinetics/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/PKC/PKC-DAG-AA /kinetics/PKC/PKC-n-DAG-AA PRODUCT n addmsg /kinetics/PKC/PKC-n-DAG-AA /kinetics/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/PKC/PKC-act-by-DAG-AA /kinetics/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/PKC/PKC-act-by-Ca /kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/PKC/PKC-basal-act /kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/PKC/PKC-act-by-AA /kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/PKC/PKC-n-DAG /kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/PKC/PKC-act-by-DAG /kinetics/DAG REAC A B addmsg /kinetics/PKC/PKC-n-DAG /kinetics/DAG REAC A B addmsg /kinetics/PLA2/DAG-Ca-PLA2-act /kinetics/DAG REAC A B addmsg /kinetics/PLCbeta/PLC-Ca-Gq/PLCb-Ca-Gq /kinetics/DAG MM_PRD pA addmsg /kinetics/PLCbeta/Degrade-DAG /kinetics/DAG REAC A B addmsg /kinetics/PLCbeta/PLC-Ca/PLC-Ca /kinetics/DAG MM_PRD pA addmsg /kinetics/PLC_g/Ca.PLC_g/PIP2_hydrolysis /kinetics/DAG MM_PRD pA addmsg /kinetics/PLC_g/Ca.PLC_g*/PIP2_hydrolysis /kinetics/DAG MM_PRD pA addmsg /kinetics/PKC/PKC-act-by-Ca /kinetics/Ca REAC A B addmsg /kinetics/PLA2/PLA2-Ca-act /kinetics/Ca REAC A B addmsg /kinetics/PLA2/PLA2*-Ca-act /kinetics/Ca REAC A B addmsg /kinetics/PLCbeta/Act-PLC-Ca /kinetics/Ca REAC A B addmsg /kinetics/PLCbeta/PLC-Gq-bind-Ca /kinetics/Ca REAC A B addmsg /kinetics/PLC_g/Ca_act_PLC_g /kinetics/Ca REAC A B addmsg /kinetics/PLC_g/Ca_act_PLC_g* /kinetics/Ca REAC A B addmsg /kinetics/CaRegulation/Ca-bind-to-Transp /kinetics/Ca REAC A B addmsg /kinetics/CaRegulation/Ca-bind-to-Transp /kinetics/Ca REAC A B addmsg /kinetics/CaRegulation/IP3R*/IP3chan /kinetics/Ca REAC B A addmsg /kinetics/CaRegulation/Ca-leak-to-cytoplasm/Ca-leak-chan /kinetics/Ca REAC B A addmsg /kinetics/CaRegulation/Ca-leak-from-extracell/Ca-leak-chan /kinetics/Ca REAC B A addmsg /kinetics/CaRegulation/CaEPump/Ca-pump-out /kinetics/Ca REAC sA B addmsg /kinetics/CaRegulation/capacitive_Ca_entry*/Cap_entry_chan /kinetics/Ca REAC B A addmsg /kinetics/PKC/PKC-act-by-Ca-AA /kinetics/AA REAC A B addmsg /kinetics/PKC/PKC-act-by-AA /kinetics/AA REAC A B addmsg /kinetics/PKC/PKC-n-DAG-AA /kinetics/AA REAC A B addmsg /kinetics/PLA2/PLA2-Ca*/kenz /kinetics/AA MM_PRD pA addmsg /kinetics/PLA2/PIP2-PLA2*/kenz /kinetics/AA MM_PRD pA addmsg /kinetics/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/AA MM_PRD pA addmsg /kinetics/PLA2/DAG-Ca-PLA2*/kenz /kinetics/AA MM_PRD pA addmsg /kinetics/PLA2/PLA2*-Ca/kenz /kinetics/AA MM_PRD pA addmsg /kinetics/PLA2/Degrade-AA /kinetics/AA REAC A B addmsg /kinetics/PKC/PKC-DAG-AA* /kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/PKC/PKC-Ca-memb* /kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/PKC/PKC-Ca-AA* /kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/PKC/PKC-DAG-memb* /kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/PKC/PKC-basal* /kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/PKC/PKC-AA* /kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/PKC-active/PKC-act-raf /kinetics/PKC-active CONSERVE nComplex nComplexInit addmsg /kinetics/PKC-active/PKC-inact-GAP /kinetics/PKC-active REAC eA B addmsg /kinetics/PKC-active/PKC-inact-GAP /kinetics/PKC-active CONSERVE nComplex nComplexInit addmsg /kinetics/PKC-active/PKC-act-GEF /kinetics/PKC-active REAC eA B addmsg /kinetics/PKC-active/PKC-act-GEF /kinetics/PKC-active CONSERVE nComplex nComplexInit addmsg /kinetics/PKC-active/PKC-act-raf /kinetics/PKC-active REAC eA B addmsg /kinetics/PKC-active /kinetics/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/MAPK/craf-1 /kinetics/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/PKC-active /kinetics/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/Ras/GAP /kinetics/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/PKC-active /kinetics/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/Ras/inact-GEF /kinetics/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/PLA2/PLA2-Ca-act /kinetics/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/PLA2/PIP2-PLA2-act /kinetics/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/PLA2/PIP2-PLA2* /kinetics/PLA2/PLA2-cytosolic CONSERVE n nInit addmsg /kinetics/PLA2/PIP2-Ca-PLA2* /kinetics/PLA2/PLA2-cytosolic CONSERVE n nInit addmsg /kinetics/PLA2/DAG-Ca-PLA2* /kinetics/PLA2/PLA2-cytosolic CONSERVE n nInit addmsg /kinetics/PLA2/PLA2-Ca* /kinetics/PLA2/PLA2-cytosolic CONSERVE n nInit addmsg /kinetics/PLA2/PLA2*-Ca /kinetics/PLA2/PLA2-cytosolic CONSERVE n nInit addmsg /kinetics/MAPK*/MAPK* /kinetics/PLA2/PLA2-cytosolic CONSERVE nComplex nComplexInit addmsg /kinetics/PLA2/PLA2*-Ca/kenz /kinetics/PLA2/PLA2-cytosolic CONSERVE nComplex nComplexInit addmsg /kinetics/PLA2/PLA2-Ca*/kenz /kinetics/PLA2/PLA2-cytosolic CONSERVE nComplex nComplexInit addmsg /kinetics/PLA2/DAG-Ca-PLA2*/kenz /kinetics/PLA2/PLA2-cytosolic CONSERVE nComplex nComplexInit addmsg /kinetics/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/PLA2/PLA2-cytosolic CONSERVE nComplex nComplexInit addmsg /kinetics/PLA2/PIP2-PLA2*/kenz /kinetics/PLA2/PLA2-cytosolic CONSERVE nComplex nComplexInit addmsg /kinetics/MAPK*/MAPK* /kinetics/PLA2/PLA2-cytosolic REAC sA B addmsg /kinetics/PLA2/PLA2* /kinetics/PLA2/PLA2-cytosolic CONSERVE n nInit addmsg /kinetics/PLA2/dephosphorylate-PLA2* /kinetics/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/PLA2/PLA2-cytosolic /kinetics/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/Ca /kinetics/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/PLA2/PLA2-Ca* /kinetics/PLA2/PLA2-Ca-act PRODUCT n addmsg /kinetics/PLA2/PLA2-Ca-act /kinetics/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/PLA2/PLA2-Ca*/kenz /kinetics/PLA2/PLA2-Ca* REAC eA B addmsg /kinetics/PLA2/PIP2-Ca-PLA2-act /kinetics/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/PLA2/DAG-Ca-PLA2-act /kinetics/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/PLA2/PLA2-Ca* /kinetics/PLA2/PLA2-Ca*/kenz ENZYME n addmsg /kinetics/PLA2/APC /kinetics/PLA2/PLA2-Ca*/kenz SUBSTRATE n addmsg /kinetics/temp-PIP2 /kinetics/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/PLA2/PLA2-cytosolic /kinetics/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/PLA2/PIP2-PLA2* /kinetics/PLA2/PIP2-PLA2-act PRODUCT n addmsg /kinetics/PLA2/PIP2-PLA2-act /kinetics/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/PLA2/PIP2-PLA2*/kenz /kinetics/PLA2/PIP2-PLA2* REAC eA B addmsg /kinetics/PLA2/PIP2-PLA2* /kinetics/PLA2/PIP2-PLA2*/kenz ENZYME n addmsg /kinetics/PLA2/APC /kinetics/PLA2/PIP2-PLA2*/kenz SUBSTRATE n addmsg /kinetics/temp-PIP2 /kinetics/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/PLA2/PLA2-Ca* /kinetics/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/PLA2/PIP2-Ca-PLA2* /kinetics/PLA2/PIP2-Ca-PLA2-act PRODUCT n addmsg /kinetics/PLA2/PIP2-Ca-PLA2-act /kinetics/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/PLA2/PIP2-Ca-PLA2* REAC eA B addmsg /kinetics/PLA2/PIP2-Ca-PLA2* /kinetics/PLA2/PIP2-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/PLA2/APC /kinetics/PLA2/PIP2-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/DAG /kinetics/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/PLA2/PLA2-Ca* /kinetics/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/PLA2/DAG-Ca-PLA2* /kinetics/PLA2/DAG-Ca-PLA2-act PRODUCT n addmsg /kinetics/PLA2/DAG-Ca-PLA2-act /kinetics/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/PLA2/DAG-Ca-PLA2*/kenz /kinetics/PLA2/DAG-Ca-PLA2* REAC eA B addmsg /kinetics/PLA2/DAG-Ca-PLA2* /kinetics/PLA2/DAG-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/PLA2/APC /kinetics/PLA2/DAG-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/PLA2/PLA2-Ca*/kenz /kinetics/PLA2/APC REAC sA B addmsg /kinetics/PLA2/PIP2-PLA2*/kenz /kinetics/PLA2/APC REAC sA B addmsg /kinetics/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/PLA2/APC REAC sA B addmsg /kinetics/PLA2/DAG-Ca-PLA2*/kenz /kinetics/PLA2/APC REAC sA B addmsg /kinetics/PLA2/PLA2*-Ca/kenz /kinetics/PLA2/APC REAC sA B addmsg /kinetics/PLA2/Degrade-AA /kinetics/PLA2/APC REAC B A addmsg /kinetics/AA /kinetics/PLA2/Degrade-AA SUBSTRATE n addmsg /kinetics/PLA2/APC /kinetics/PLA2/Degrade-AA PRODUCT n addmsg /kinetics/PLA2/PLA2*-Ca/kenz /kinetics/PLA2/PLA2*-Ca REAC eA B addmsg /kinetics/PLA2/PLA2*-Ca-act /kinetics/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/PLA2/PLA2*-Ca /kinetics/PLA2/PLA2*-Ca/kenz ENZYME n addmsg /kinetics/PLA2/APC /kinetics/PLA2/PLA2*-Ca/kenz SUBSTRATE n addmsg /kinetics/MAPK*/MAPK* /kinetics/PLA2/PLA2* MM_PRD pA addmsg /kinetics/PLA2/PLA2*-Ca-act /kinetics/PLA2/PLA2* REAC A B addmsg /kinetics/PLA2/dephosphorylate-PLA2* /kinetics/PLA2/PLA2* REAC A B addmsg /kinetics/PLA2/PLA2* /kinetics/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/PLA2/PLA2*-Ca /kinetics/PLA2/PLA2*-Ca-act PRODUCT n addmsg /kinetics/Ca /kinetics/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/PLA2/PLA2* /kinetics/PLA2/dephosphorylate-PLA2* SUBSTRATE n addmsg /kinetics/PLA2/PLA2-cytosolic /kinetics/PLA2/dephosphorylate-PLA2* PRODUCT n addmsg /kinetics/MAPK*/MAPK* /kinetics/MAPK* REAC eA B addmsg /kinetics/MAPK*/MAPK*-feedback /kinetics/MAPK* REAC eA B addmsg /kinetics/MAPK/MAPKK*/MAPKKthr /kinetics/MAPK* MM_PRD pA addmsg /kinetics/MKP-1/MKP1-thr-deph /kinetics/MAPK* REAC sA B addmsg /kinetics/MAPK*/phosph_Sos /kinetics/MAPK* REAC eA B addmsg /kinetics/MAPK* /kinetics/MAPK*/MAPK* ENZYME n addmsg /kinetics/PLA2/PLA2-cytosolic /kinetics/MAPK*/MAPK* SUBSTRATE n addmsg /kinetics/MAPK* /kinetics/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/MAPK/craf-1* /kinetics/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/MAPK* /kinetics/MAPK*/phosph_Sos ENZYME n addmsg /kinetics/Sos/Sos /kinetics/MAPK*/phosph_Sos SUBSTRATE n addmsg /kinetics/PLA2/PIP2-PLA2-act /kinetics/temp-PIP2 REAC A B addmsg /kinetics/PLA2/PIP2-Ca-PLA2-act /kinetics/temp-PIP2 REAC A B addmsg /kinetics/PLCbeta/PLC-Ca-Gq/PLCb-Ca-Gq /kinetics/IP3 MM_PRD pA addmsg /kinetics/PLCbeta/Degrade-IP3 /kinetics/IP3 REAC A B addmsg /kinetics/PLCbeta/PLC-Ca/PLC-Ca /kinetics/IP3 MM_PRD pA addmsg /kinetics/PLC_g/Ca.PLC_g/PIP2_hydrolysis /kinetics/IP3 MM_PRD pA addmsg /kinetics/PLC_g/Ca.PLC_g*/PIP2_hydrolysis /kinetics/IP3 MM_PRD pA addmsg /kinetics/CaRegulation/IP3Rbind /kinetics/IP3 REAC A B addmsg /kinetics/CaRegulation/IP3Rbind /kinetics/IP3 REAC A B addmsg /kinetics/CaRegulation/IP3Rbind /kinetics/IP3 REAC A B addmsg /kinetics/Gq/RecLigandBinding /kinetics/Glu REAC A B addmsg /kinetics/Gq/Glu-bind-Rec-Gq /kinetics/Glu REAC A B addmsg /kinetics/Ca /kinetics/PLCbeta/Act-PLC-Ca SUBSTRATE n addmsg /kinetics/PLCbeta/PLC /kinetics/PLCbeta/Act-PLC-Ca SUBSTRATE n addmsg /kinetics/PLCbeta/PLC-Ca /kinetics/PLCbeta/Act-PLC-Ca PRODUCT n addmsg /kinetics/PLCbeta/PLC-Ca-Gq /kinetics/PLCbeta/PLC CONSERVE n nInit addmsg /kinetics/PLCbeta/PLC-Ca-Gq/PLCb-Ca-Gq /kinetics/PLCbeta/PLC CONSERVE nComplex nComplexInit addmsg /kinetics/PLCbeta/Act-PLC-Ca /kinetics/PLCbeta/PLC REAC A B addmsg /kinetics/PLCbeta/PLC-Ca /kinetics/PLCbeta/PLC CONSERVE n nInit addmsg /kinetics/PLCbeta/PLC-Ca/PLC-Ca /kinetics/PLCbeta/PLC CONSERVE nComplex nComplexInit addmsg /kinetics/PLCbeta/PLC-bind-Gq /kinetics/PLCbeta/PLC REAC A B addmsg /kinetics/PLCbeta/PLC-Gq /kinetics/PLCbeta/PLC CONSERVE n nInit addmsg /kinetics/IP3 /kinetics/PLCbeta/Degrade-IP3 SUBSTRATE n addmsg /kinetics/PLCbeta/Inositol /kinetics/PLCbeta/Degrade-IP3 PRODUCT n addmsg /kinetics/PLCbeta/Degrade-IP3 /kinetics/PLCbeta/Inositol REAC B A addmsg /kinetics/PLCbeta/PC /kinetics/PLCbeta/Degrade-DAG PRODUCT n addmsg /kinetics/DAG /kinetics/PLCbeta/Degrade-DAG SUBSTRATE n addmsg /kinetics/PLCbeta/Degrade-DAG /kinetics/PLCbeta/PC REAC B A addmsg /kinetics/PLCbeta/Act-PLC-Ca /kinetics/PLCbeta/PLC-Ca REAC B A addmsg /kinetics/PLCbeta/Act-PLC-by-Gq /kinetics/PLCbeta/PLC-Ca REAC A B addmsg /kinetics/PLCbeta/Inact-PLC-Gq /kinetics/PLCbeta/PLC-Ca REAC B A addmsg /kinetics/PLCbeta/PLC-Ca/PLC-Ca /kinetics/PLCbeta/PLC-Ca REAC eA B addmsg /kinetics/PLCbeta/PLC-Ca /kinetics/PLCbeta/PLC-Ca/PLC-Ca ENZYME n addmsg /kinetics/PIP2 /kinetics/PLCbeta/PLC-Ca/PLC-Ca SUBSTRATE n addmsg /kinetics/G*GTP /kinetics/PLCbeta/Act-PLC-by-Gq SUBSTRATE n addmsg /kinetics/PLCbeta/PLC-Ca /kinetics/PLCbeta/Act-PLC-by-Gq SUBSTRATE n addmsg /kinetics/PLCbeta/PLC-Ca-Gq /kinetics/PLCbeta/Act-PLC-by-Gq PRODUCT n addmsg /kinetics/G*GDP /kinetics/PLCbeta/Inact-PLC-Gq PRODUCT n addmsg /kinetics/PLCbeta/PLC-Ca-Gq /kinetics/PLCbeta/Inact-PLC-Gq SUBSTRATE n addmsg /kinetics/PLCbeta/PLC-Ca /kinetics/PLCbeta/Inact-PLC-Gq PRODUCT n addmsg /kinetics/PLCbeta/PLC-Ca-Gq/PLCb-Ca-Gq /kinetics/PLCbeta/PLC-Ca-Gq REAC eA B addmsg /kinetics/PLCbeta/Act-PLC-by-Gq /kinetics/PLCbeta/PLC-Ca-Gq REAC B A addmsg /kinetics/PLCbeta/Inact-PLC-Gq /kinetics/PLCbeta/PLC-Ca-Gq REAC A B addmsg /kinetics/PLCbeta/PLC-Gq-bind-Ca /kinetics/PLCbeta/PLC-Ca-Gq REAC B A addmsg /kinetics/PLCbeta/PLC-Ca-Gq /kinetics/PLCbeta/PLC-Ca-Gq/PLCb-Ca-Gq ENZYME n addmsg /kinetics/PIP2 /kinetics/PLCbeta/PLC-Ca-Gq/PLCb-Ca-Gq SUBSTRATE n addmsg /kinetics/PLCbeta/PLC-bind-Gq /kinetics/PLCbeta/PLC-Gq REAC B A addmsg /kinetics/PLCbeta/PLC-Gq-bind-Ca /kinetics/PLCbeta/PLC-Gq REAC A B addmsg /kinetics/PLCbeta/PLC /kinetics/PLCbeta/PLC-bind-Gq SUBSTRATE n addmsg /kinetics/G*GTP /kinetics/PLCbeta/PLC-bind-Gq SUBSTRATE n addmsg /kinetics/PLCbeta/PLC-Gq /kinetics/PLCbeta/PLC-bind-Gq PRODUCT n addmsg /kinetics/Ca /kinetics/PLCbeta/PLC-Gq-bind-Ca SUBSTRATE n addmsg /kinetics/PLCbeta/PLC-Gq /kinetics/PLCbeta/PLC-Gq-bind-Ca SUBSTRATE n addmsg /kinetics/PLCbeta/PLC-Ca-Gq /kinetics/PLCbeta/PLC-Gq-bind-Ca PRODUCT n addmsg /kinetics/PLCbeta/PLC-Ca-Gq/PLCb-Ca-Gq /kinetics/PIP2 REAC sA B addmsg /kinetics/PLCbeta/PLC-Ca/PLC-Ca /kinetics/PIP2 REAC sA B addmsg /kinetics/PLC_g/Ca.PLC_g*/PIP2_hydrolysis /kinetics/PIP2 REAC sA B addmsg /kinetics/PLC_g/Ca.PLC_g/PIP2_hydrolysis /kinetics/PIP2 REAC sA B addmsg /kinetics/Gq/Trimerize-G /kinetics/BetaGamma REAC A B addmsg /kinetics/Gq/Basal-Act-G /kinetics/BetaGamma REAC B A addmsg /kinetics/Gq/Activate-Gq /kinetics/BetaGamma REAC B A addmsg /kinetics/Ras/bg-act-GEF /kinetics/BetaGamma REAC A B addmsg /kinetics/PLCbeta/Act-PLC-by-Gq /kinetics/G*GTP REAC A B addmsg /kinetics/PLCbeta/PLC-bind-Gq /kinetics/G*GTP REAC A B addmsg /kinetics/Gq/Inact-G /kinetics/G*GTP REAC A B addmsg /kinetics/Gq/Basal-Act-G /kinetics/G*GTP REAC B A addmsg /kinetics/Gq/Activate-Gq /kinetics/G*GTP REAC B A addmsg /kinetics/PLCbeta/Inact-PLC-Gq /kinetics/G*GDP REAC B A addmsg /kinetics/Gq/Inact-G /kinetics/G*GDP REAC B A addmsg /kinetics/Gq/Trimerize-G /kinetics/G*GDP REAC A B addmsg /kinetics/Gq/mGluR /kinetics/Gq/RecLigandBinding SUBSTRATE n addmsg /kinetics/Glu /kinetics/Gq/RecLigandBinding SUBSTRATE n addmsg /kinetics/Gq/Rec-Glu /kinetics/Gq/RecLigandBinding PRODUCT n addmsg /kinetics/Gq/Trimerize-G /kinetics/Gq/G-GDP REAC B A addmsg /kinetics/Gq/Basal-Act-G /kinetics/Gq/G-GDP REAC A B addmsg /kinetics/Gq/Rec-Glu-bind-Gq /kinetics/Gq/G-GDP REAC A B addmsg /kinetics/Gq/Rec-bind-Gq /kinetics/Gq/G-GDP REAC A B addmsg /kinetics/Gq/G-GDP /kinetics/Gq/Basal-Act-G SUBSTRATE n addmsg /kinetics/G*GTP /kinetics/Gq/Basal-Act-G PRODUCT n addmsg /kinetics/BetaGamma /kinetics/Gq/Basal-Act-G PRODUCT n addmsg /kinetics/G*GDP /kinetics/Gq/Trimerize-G SUBSTRATE n addmsg /kinetics/BetaGamma /kinetics/Gq/Trimerize-G SUBSTRATE n addmsg /kinetics/Gq/G-GDP /kinetics/Gq/Trimerize-G PRODUCT n addmsg /kinetics/G*GTP /kinetics/Gq/Inact-G SUBSTRATE n addmsg /kinetics/G*GDP /kinetics/Gq/Inact-G PRODUCT n addmsg /kinetics/Gq/RecLigandBinding /kinetics/Gq/mGluR REAC A B addmsg /kinetics/Gq/Rec-Glu /kinetics/Gq/mGluR CONSERVE n nInit addmsg /kinetics/Gq/Rec-Glu-Gq /kinetics/Gq/mGluR CONSERVE n nInit addmsg /kinetics/Gq/Rec-Gq /kinetics/Gq/mGluR CONSERVE n nInit addmsg /kinetics/Gq/Rec-bind-Gq /kinetics/Gq/mGluR REAC A B addmsg /kinetics/Gq/Blocked-rec-Gq /kinetics/Gq/mGluR CONSERVE n nInit addmsg /kinetics/Gq/RecLigandBinding /kinetics/Gq/Rec-Glu REAC B A addmsg /kinetics/Gq/Rec-Glu-bind-Gq /kinetics/Gq/Rec-Glu REAC A B addmsg /kinetics/Gq/Activate-Gq /kinetics/Gq/Rec-Glu REAC B A addmsg /kinetics/Gq/Glu-bind-Rec-Gq /kinetics/Gq/Rec-Gq REAC A B addmsg /kinetics/Gq/Rec-bind-Gq /kinetics/Gq/Rec-Gq REAC B A addmsg /kinetics/Gq/Antag-bind-Rec-Gq /kinetics/Gq/Rec-Gq REAC A B addmsg /kinetics/Gq/G-GDP /kinetics/Gq/Rec-Glu-bind-Gq SUBSTRATE n addmsg /kinetics/Gq/Rec-Glu /kinetics/Gq/Rec-Glu-bind-Gq SUBSTRATE n addmsg /kinetics/Gq/Rec-Glu-Gq /kinetics/Gq/Rec-Glu-bind-Gq PRODUCT n addmsg /kinetics/Glu /kinetics/Gq/Glu-bind-Rec-Gq SUBSTRATE n addmsg /kinetics/Gq/Rec-Glu-Gq /kinetics/Gq/Glu-bind-Rec-Gq PRODUCT n addmsg /kinetics/Gq/Rec-Gq /kinetics/Gq/Glu-bind-Rec-Gq SUBSTRATE n addmsg /kinetics/Gq/Rec-Glu-bind-Gq /kinetics/Gq/Rec-Glu-Gq REAC B A addmsg /kinetics/Gq/Glu-bind-Rec-Gq /kinetics/Gq/Rec-Glu-Gq REAC B A addmsg /kinetics/Gq/Activate-Gq /kinetics/Gq/Rec-Glu-Gq REAC A B addmsg /kinetics/Gq/Rec-Glu-Gq /kinetics/Gq/Activate-Gq SUBSTRATE n addmsg /kinetics/G*GTP /kinetics/Gq/Activate-Gq PRODUCT n addmsg /kinetics/BetaGamma /kinetics/Gq/Activate-Gq PRODUCT n addmsg /kinetics/Gq/Rec-Glu /kinetics/Gq/Activate-Gq PRODUCT n addmsg /kinetics/Gq/G-GDP /kinetics/Gq/Rec-bind-Gq SUBSTRATE n addmsg /kinetics/Gq/mGluR /kinetics/Gq/Rec-bind-Gq SUBSTRATE n addmsg /kinetics/Gq/Rec-Gq /kinetics/Gq/Rec-bind-Gq PRODUCT n addmsg /kinetics/Gq/Antag-bind-Rec-Gq /kinetics/Gq/mGluRAntag REAC A B addmsg /kinetics/Gq/Rec-Gq /kinetics/Gq/Antag-bind-Rec-Gq SUBSTRATE n addmsg /kinetics/Gq/mGluRAntag /kinetics/Gq/Antag-bind-Rec-Gq SUBSTRATE n addmsg /kinetics/Gq/Blocked-rec-Gq /kinetics/Gq/Antag-bind-Rec-Gq PRODUCT n addmsg /kinetics/Gq/Antag-bind-Rec-Gq /kinetics/Gq/Blocked-rec-Gq REAC B A addmsg /kinetics/PKC-active/PKC-act-raf /kinetics/MAPK/craf-1 REAC sA B addmsg /kinetics/PPhosphatase2A/craf-deph /kinetics/MAPK/craf-1 MM_PRD pA addmsg /kinetics/PKC-active/PKC-act-raf /kinetics/MAPK/craf-1* MM_PRD pA addmsg /kinetics/MAPK*/MAPK*-feedback /kinetics/MAPK/craf-1* REAC sA B addmsg /kinetics/PPhosphatase2A/craf-deph /kinetics/MAPK/craf-1* REAC sA B addmsg /kinetics/PPhosphatase2A/craf**-deph /kinetics/MAPK/craf-1* MM_PRD pA addmsg /kinetics/Ras-act-craf /kinetics/MAPK/craf-1* REAC A B addmsg /kinetics/PPhosphatase2A/MAPKK-deph-ser /kinetics/MAPK/MAPKK MM_PRD pA addmsg /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.1 /kinetics/MAPK/MAPKK REAC sA B addmsg /kinetics/MAPK/MAPKK*/MAPKKtyr /kinetics/MAPK/MAPK REAC sA B addmsg /kinetics/MKP-1/MKP1-tyr-deph /kinetics/MAPK/MAPK MM_PRD pA addmsg /kinetics/MAPK*/MAPK*-feedback /kinetics/MAPK/craf-1** MM_PRD pA addmsg /kinetics/PPhosphatase2A/craf**-deph /kinetics/MAPK/craf-1** REAC sA B addmsg /kinetics/MAPK/MAPKK*/MAPKKtyr /kinetics/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/MAPK/MAPKK*/MAPKKthr /kinetics/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/MKP-1/MKP1-tyr-deph /kinetics/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/MKP-1/MKP1-thr-deph /kinetics/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/MAPK/MAPKK*/MAPKKtyr /kinetics/MAPK/MAPKK* REAC eA B addmsg /kinetics/MAPK/MAPKK*/MAPKKthr /kinetics/MAPK/MAPKK* REAC eA B addmsg /kinetics/PPhosphatase2A/MAPKK-deph /kinetics/MAPK/MAPKK* REAC sA B addmsg /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.2 /kinetics/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/MAPK/MAPKK* /kinetics/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/MAPK/MAPK /kinetics/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/MAPK/MAPKK* /kinetics/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/MAPK/MAPK-tyr /kinetics/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/PPhosphatase2A/MAPKK-deph /kinetics/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/PPhosphatase2A/MAPKK-deph-ser /kinetics/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.1 /kinetics/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.2 /kinetics/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/Ras-act-craf /kinetics/MAPK/Raf-GTP-Ras* REAC B A addmsg /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.1 /kinetics/MAPK/Raf-GTP-Ras* REAC eA B addmsg /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.2 /kinetics/MAPK/Raf-GTP-Ras* REAC eA B addmsg /kinetics/MAPK/Raf-GTP-Ras* /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.1 ENZYME n addmsg /kinetics/MAPK/MAPKK /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.1 SUBSTRATE n addmsg /kinetics/MAPK/Raf-GTP-Ras* /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.2 ENZYME n addmsg /kinetics/MAPK/MAPKK-ser /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.2 SUBSTRATE n addmsg /kinetics/MKP-1/MKP1-tyr-deph /kinetics/MKP-1 REAC eA B addmsg /kinetics/MKP-1/MKP1-thr-deph /kinetics/MKP-1 REAC eA B addmsg /kinetics/MKP-1 /kinetics/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/MAPK/MAPK-tyr /kinetics/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/MKP-1 /kinetics/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/MAPK* /kinetics/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/MAPK/Raf-GTP-Ras* /kinetics/Ras-act-craf PRODUCT n addmsg /kinetics/MAPK/craf-1* /kinetics/Ras-act-craf SUBSTRATE n addmsg /kinetics/Ras/GTP-Ras /kinetics/Ras-act-craf SUBSTRATE n addmsg /kinetics/PPhosphatase2A/craf-deph /kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/PPhosphatase2A/MAPKK-deph /kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/PPhosphatase2A/MAPKK-deph-ser /kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/PPhosphatase2A/craf**-deph /kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/MAPK/craf-1* /kinetics/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/MAPK/MAPKK* /kinetics/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/MAPK/MAPKK-ser /kinetics/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/MAPK/craf-1** /kinetics/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/BetaGamma /kinetics/Ras/bg-act-GEF SUBSTRATE n addmsg /kinetics/Ras/inact-GEF /kinetics/Ras/bg-act-GEF SUBSTRATE n addmsg /kinetics/Ras/GEF-Gprot-bg /kinetics/Ras/bg-act-GEF PRODUCT n addmsg /kinetics/Ras/GEF-Gprot-bg/GEF-bg_act-ras /kinetics/Ras/GEF-Gprot-bg REAC eA B addmsg /kinetics/Ras/bg-act-GEF /kinetics/Ras/GEF-Gprot-bg REAC B A addmsg /kinetics/Ras/GEF-Gprot-bg /kinetics/Ras/GEF-Gprot-bg/GEF-bg_act-ras ENZYME n addmsg /kinetics/Ras/GDP-Ras /kinetics/Ras/GEF-Gprot-bg/GEF-bg_act-ras SUBSTRATE n addmsg /kinetics/Ras/GEF* /kinetics/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/Ras/inact-GEF /kinetics/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/Ras/bg-act-GEF /kinetics/Ras/inact-GEF REAC A B addmsg /kinetics/PKC-active/PKC-act-GEF /kinetics/Ras/inact-GEF REAC sA B addmsg /kinetics/Ras/dephosph-GEF /kinetics/Ras/inact-GEF REAC B A addmsg /kinetics/PKA-active/PKA-phosph-GEF /kinetics/Ras/inact-GEF REAC sA B addmsg /kinetics/Ras/CaM-bind-GEF /kinetics/Ras/inact-GEF REAC A B addmsg /kinetics/Ras/dephosph-inact-GEF* /kinetics/Ras/inact-GEF REAC B A addmsg /kinetics/PKC-active/PKC-act-GEF /kinetics/Ras/GEF* MM_PRD pA addmsg /kinetics/Ras/dephosph-GEF /kinetics/Ras/GEF* REAC A B addmsg /kinetics/Ras/GEF*/GEF*-act-ras /kinetics/Ras/GEF* REAC eA B addmsg /kinetics/Ras/GEF* /kinetics/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/Ras/GDP-Ras /kinetics/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/Ras/GEF-Gprot-bg/GEF-bg_act-ras /kinetics/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/Ras/GAP/GAP-inact-ras /kinetics/Ras/GTP-Ras REAC sA B addmsg /kinetics/Ras/Ras-intrinsic-GTPase /kinetics/Ras/GTP-Ras REAC A B addmsg /kinetics/Ras/GEF*/GEF*-act-ras /kinetics/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/Ras-act-craf /kinetics/Ras/GTP-Ras REAC A B addmsg /kinetics/Shc*.Sos.Grb2/Sos.Ras_GEF /kinetics/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/Ras/GEF-Gprot-bg/GEF-bg_act-ras /kinetics/Ras/GDP-Ras REAC sA B addmsg /kinetics/Ras/GAP/GAP-inact-ras /kinetics/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/Ras/Ras-intrinsic-GTPase /kinetics/Ras/GDP-Ras REAC B A addmsg /kinetics/Ras/GEF*/GEF*-act-ras /kinetics/Ras/GDP-Ras REAC sA B addmsg /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/Ras/GDP-Ras REAC sA B addmsg /kinetics/Shc*.Sos.Grb2/Sos.Ras_GEF /kinetics/Ras/GDP-Ras REAC sA B addmsg /kinetics/Ras/GTP-Ras /kinetics/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/Ras/GDP-Ras /kinetics/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/Ras/GAP* /kinetics/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/Ras/GAP /kinetics/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/PKC-active/PKC-inact-GAP /kinetics/Ras/GAP* MM_PRD pA addmsg /kinetics/Ras/dephosph-GAP /kinetics/Ras/GAP* REAC A B addmsg /kinetics/Ras/GAP/GAP-inact-ras /kinetics/Ras/GAP REAC eA B addmsg /kinetics/PKC-active/PKC-inact-GAP /kinetics/Ras/GAP REAC sA B addmsg /kinetics/Ras/dephosph-GAP /kinetics/Ras/GAP REAC B A addmsg /kinetics/Ras/GAP /kinetics/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/Ras/GTP-Ras /kinetics/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/PKA-active/PKA-phosph-GEF /kinetics/Ras/inact-GEF* MM_PRD pA addmsg /kinetics/Ras/dephosph-inact-GEF* /kinetics/Ras/inact-GEF* REAC A B addmsg /kinetics/Ras/inact-GEF /kinetics/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/Ras/CaM-GEF /kinetics/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/CaM-Ca4 /kinetics/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/Ras/CaM-bind-GEF /kinetics/Ras/CaM-GEF REAC B A addmsg /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/Ras/CaM-GEF REAC eA B addmsg /kinetics/Ras/CaM-GEF /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/Ras/GDP-Ras /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/Ras/inact-GEF* /kinetics/Ras/dephosph-inact-GEF* SUBSTRATE n addmsg /kinetics/Ras/inact-GEF /kinetics/Ras/dephosph-inact-GEF* PRODUCT n addmsg /kinetics/PKA-active/PKA-phosph-GEF /kinetics/PKA-active REAC eA B addmsg /kinetics/PKA-active /kinetics/PKA-active/PKA-phosph-GEF ENZYME n addmsg /kinetics/Ras/inact-GEF /kinetics/PKA-active/PKA-phosph-GEF SUBSTRATE n addmsg /kinetics/Ras/CaM-bind-GEF /kinetics/CaM-Ca4 REAC A B addmsg /kinetics/Sos/Shc_bind_Sos.Grb2 /kinetics/Shc*.Sos.Grb2 REAC B A addmsg /kinetics/Shc*.Sos.Grb2/Sos.Ras_GEF /kinetics/Shc*.Sos.Grb2 REAC eA B addmsg /kinetics/Shc*.Sos.Grb2 /kinetics/Shc*.Sos.Grb2/Sos.Ras_GEF ENZYME n addmsg /kinetics/Ras/GDP-Ras /kinetics/Shc*.Sos.Grb2/Sos.Ras_GEF SUBSTRATE n addmsg /kinetics/EGFR/act_EGFR /kinetics/EGFR/EGFR REAC A B addmsg /kinetics/EGFR/EGFR /kinetics/EGFR/act_EGFR SUBSTRATE n addmsg /kinetics/EGFR/EGF /kinetics/EGFR/act_EGFR SUBSTRATE n addmsg /kinetics/EGFR/L.EGFR /kinetics/EGFR/act_EGFR PRODUCT n addmsg /kinetics/EGFR/act_EGFR /kinetics/EGFR/L.EGFR REAC B A addmsg /kinetics/EGFR/L.EGFR/phosph_PLC_g /kinetics/EGFR/L.EGFR REAC eA B addmsg /kinetics/EGFR/L.EGFR/phosph_Shc /kinetics/EGFR/L.EGFR REAC eA B addmsg /kinetics/EGFR/Internalize /kinetics/EGFR/L.EGFR REAC A B addmsg /kinetics/EGFR/L.EGFR /kinetics/EGFR/L.EGFR/phosph_PLC_g ENZYME n addmsg /kinetics/PLC_g/Ca.PLC_g /kinetics/EGFR/L.EGFR/phosph_PLC_g SUBSTRATE n addmsg /kinetics/EGFR/L.EGFR /kinetics/EGFR/L.EGFR/phosph_Shc ENZYME n addmsg /kinetics/EGFR/SHC /kinetics/EGFR/L.EGFR/phosph_Shc SUBSTRATE n addmsg /kinetics/EGFR/act_EGFR /kinetics/EGFR/EGF REAC A B addmsg /kinetics/EGFR/dephosph_Shc /kinetics/EGFR/SHC REAC B A addmsg /kinetics/EGFR/L.EGFR/phosph_Shc /kinetics/EGFR/SHC REAC sA B addmsg /kinetics/EGFR/dephosph_Shc /kinetics/EGFR/SHC* REAC A B addmsg /kinetics/Sos/Shc_bind_Sos.Grb2 /kinetics/EGFR/SHC* REAC A B addmsg /kinetics/EGFR/L.EGFR/phosph_Shc /kinetics/EGFR/SHC* MM_PRD pA addmsg /kinetics/EGFR/SHC* /kinetics/EGFR/dephosph_Shc SUBSTRATE n addmsg /kinetics/EGFR/SHC /kinetics/EGFR/dephosph_Shc PRODUCT n addmsg /kinetics/EGFR/Internalize /kinetics/EGFR/Internal_L.EGFR REAC B A addmsg /kinetics/EGFR/L.EGFR /kinetics/EGFR/Internalize SUBSTRATE n addmsg /kinetics/EGFR/Internal_L.EGFR /kinetics/EGFR/Internalize PRODUCT n addmsg /kinetics/Sos/Sos.Grb2 /kinetics/Sos/Shc_bind_Sos.Grb2 SUBSTRATE n addmsg /kinetics/EGFR/SHC* /kinetics/Sos/Shc_bind_Sos.Grb2 SUBSTRATE n addmsg /kinetics/Shc*.Sos.Grb2 /kinetics/Sos/Shc_bind_Sos.Grb2 PRODUCT n addmsg /kinetics/Sos/Grb2_bind_Sos* /kinetics/Sos/Sos*.Grb2 REAC B A addmsg /kinetics/Sos/Sos* /kinetics/Sos/Grb2_bind_Sos* SUBSTRATE n addmsg /kinetics/Sos/Grb2 /kinetics/Sos/Grb2_bind_Sos* SUBSTRATE n addmsg /kinetics/Sos/Sos*.Grb2 /kinetics/Sos/Grb2_bind_Sos* PRODUCT n addmsg /kinetics/Sos/Grb2_bind_Sos /kinetics/Sos/Grb2 REAC A B addmsg /kinetics/Sos/Grb2_bind_Sos* /kinetics/Sos/Grb2 REAC A B addmsg /kinetics/Sos/Grb2_bind_Sos /kinetics/Sos/Sos.Grb2 REAC B A addmsg /kinetics/Sos/Shc_bind_Sos.Grb2 /kinetics/Sos/Sos.Grb2 REAC A B addmsg /kinetics/MAPK*/phosph_Sos /kinetics/Sos/Sos* MM_PRD pA addmsg /kinetics/Sos/Grb2_bind_Sos* /kinetics/Sos/Sos* REAC A B addmsg /kinetics/Sos/dephosph_Sos /kinetics/Sos/Sos* REAC A B addmsg /kinetics/Sos/Sos* /kinetics/Sos/dephosph_Sos SUBSTRATE n addmsg /kinetics/Sos/Sos /kinetics/Sos/dephosph_Sos PRODUCT n addmsg /kinetics/Sos/Grb2 /kinetics/Sos/Grb2_bind_Sos SUBSTRATE n addmsg /kinetics/Sos/Sos.Grb2 /kinetics/Sos/Grb2_bind_Sos PRODUCT n addmsg /kinetics/Sos/Sos /kinetics/Sos/Grb2_bind_Sos SUBSTRATE n addmsg /kinetics/Sos/Grb2_bind_Sos /kinetics/Sos/Sos REAC A B addmsg /kinetics/MAPK*/phosph_Sos /kinetics/Sos/Sos REAC sA B addmsg /kinetics/Sos/dephosph_Sos /kinetics/Sos/Sos REAC B A addmsg /kinetics/PLC_g/Ca_act_PLC_g /kinetics/PLC_g/PLC_g REAC A B addmsg /kinetics/PLC_g/PLC_g /kinetics/PLC_g/Ca_act_PLC_g SUBSTRATE n addmsg /kinetics/Ca /kinetics/PLC_g/Ca_act_PLC_g SUBSTRATE n addmsg /kinetics/PLC_g/Ca.PLC_g /kinetics/PLC_g/Ca_act_PLC_g PRODUCT n addmsg /kinetics/Ca /kinetics/PLC_g/Ca_act_PLC_g* SUBSTRATE n addmsg /kinetics/PLC_g/PLC_G* /kinetics/PLC_g/Ca_act_PLC_g* SUBSTRATE n addmsg /kinetics/PLC_g/Ca.PLC_g* /kinetics/PLC_g/Ca_act_PLC_g* PRODUCT n addmsg /kinetics/PLC_g/Ca.PLC_g* /kinetics/PLC_g/dephosph_PLC_g SUBSTRATE n addmsg /kinetics/PLC_g/Ca.PLC_g /kinetics/PLC_g/dephosph_PLC_g PRODUCT n addmsg /kinetics/PLC_g/Ca_act_PLC_g* /kinetics/PLC_g/PLC_G* REAC A B addmsg /kinetics/PLC_g/Ca_act_PLC_g /kinetics/PLC_g/Ca.PLC_g REAC B A addmsg /kinetics/EGFR/L.EGFR/phosph_PLC_g /kinetics/PLC_g/Ca.PLC_g REAC sA B addmsg /kinetics/PLC_g/dephosph_PLC_g /kinetics/PLC_g/Ca.PLC_g REAC B A addmsg /kinetics/PLC_g/Ca.PLC_g /kinetics/PLC_g/Ca.PLC_g/PIP2_hydrolysis ENZYME n addmsg /kinetics/PIP2 /kinetics/PLC_g/Ca.PLC_g/PIP2_hydrolysis SUBSTRATE n addmsg /kinetics/PLC_g/Ca_act_PLC_g* /kinetics/PLC_g/Ca.PLC_g* REAC B A addmsg /kinetics/EGFR/L.EGFR/phosph_PLC_g /kinetics/PLC_g/Ca.PLC_g* MM_PRD pA addmsg /kinetics/PLC_g/dephosph_PLC_g /kinetics/PLC_g/Ca.PLC_g* REAC A B addmsg /kinetics/PLC_g/Ca.PLC_g* /kinetics/PLC_g/Ca.PLC_g*/PIP2_hydrolysis ENZYME n addmsg /kinetics/PIP2 /kinetics/PLC_g/Ca.PLC_g*/PIP2_hydrolysis SUBSTRATE n addmsg /kinetics/CaRegulation/CaTransp-2Ca /kinetics/CaRegulation/CaTraspATPase SUBSTRATE n addmsg /kinetics/CaRegulation/CaTransp /kinetics/CaRegulation/CaTraspATPase PRODUCT n addmsg /kinetics/CaRegulation/Ca-sequester /kinetics/CaRegulation/CaTraspATPase PRODUCT n addmsg /kinetics/CaRegulation/Ca-sequester /kinetics/CaRegulation/CaTraspATPase PRODUCT n addmsg /kinetics/CaRegulation/CaTraspATPase /kinetics/CaRegulation/Ca-sequester REAC B A addmsg /kinetics/CaRegulation/IP3R*/IP3chan /kinetics/CaRegulation/Ca-sequester REAC A B addmsg /kinetics/CaRegulation/Ca-leak-to-cytoplasm/Ca-leak-chan /kinetics/CaRegulation/Ca-sequester REAC A B addmsg /kinetics/CaRegulation/CaTraspATPase /kinetics/CaRegulation/Ca-sequester REAC B A addmsg /kinetics/CaRegulation/inactivate_cap_Ca /kinetics/CaRegulation/Ca-sequester REAC A B addmsg /kinetics/CaRegulation/inactivate_cap_Ca /kinetics/CaRegulation/Ca-sequester REAC A B addmsg /kinetics/CaRegulation/Ca-leak-to-cytoplasm /kinetics/CaRegulation/Ca-leak-to-cytoplasm/Ca-leak-chan NUMCHAN n addmsg /kinetics/CaRegulation/Ca-sequester /kinetics/CaRegulation/Ca-leak-to-cytoplasm/Ca-leak-chan SUBSTRATE n vol addmsg /kinetics/Ca /kinetics/CaRegulation/Ca-leak-to-cytoplasm/Ca-leak-chan PRODUCT n vol addmsg /kinetics/CaRegulation/CaTraspATPase /kinetics/CaRegulation/CaTransp-2Ca REAC A B addmsg /kinetics/CaRegulation/Ca-bind-to-Transp /kinetics/CaRegulation/CaTransp-2Ca REAC B A addmsg /kinetics/CaRegulation/CaTransp /kinetics/CaRegulation/CaTransp-2Ca CONSERVE n nInit addmsg /kinetics/CaRegulation/Ca-bind-to-Transp /kinetics/CaRegulation/CaTransp REAC A B addmsg /kinetics/CaRegulation/CaTraspATPase /kinetics/CaRegulation/CaTransp REAC B A addmsg /kinetics/Ca /kinetics/CaRegulation/Ca-bind-to-Transp SUBSTRATE n addmsg /kinetics/CaRegulation/CaTransp /kinetics/CaRegulation/Ca-bind-to-Transp SUBSTRATE n addmsg /kinetics/Ca /kinetics/CaRegulation/Ca-bind-to-Transp SUBSTRATE n addmsg /kinetics/CaRegulation/CaTransp-2Ca /kinetics/CaRegulation/Ca-bind-to-Transp PRODUCT n addmsg /kinetics/CaRegulation/IP3Rbind /kinetics/CaRegulation/IP3R REAC A B addmsg /kinetics/CaRegulation/IP3R* /kinetics/CaRegulation/IP3Rbind PRODUCT n addmsg /kinetics/CaRegulation/IP3R /kinetics/CaRegulation/IP3Rbind SUBSTRATE n addmsg /kinetics/IP3 /kinetics/CaRegulation/IP3Rbind SUBSTRATE n addmsg /kinetics/IP3 /kinetics/CaRegulation/IP3Rbind SUBSTRATE n addmsg /kinetics/IP3 /kinetics/CaRegulation/IP3Rbind SUBSTRATE n addmsg /kinetics/CaRegulation/IP3Rbind /kinetics/CaRegulation/IP3R* REAC B A addmsg /kinetics/CaRegulation/IP3R* /kinetics/CaRegulation/IP3R*/IP3chan NUMCHAN n addmsg /kinetics/CaRegulation/Ca-sequester /kinetics/CaRegulation/IP3R*/IP3chan SUBSTRATE n vol addmsg /kinetics/Ca /kinetics/CaRegulation/IP3R*/IP3chan PRODUCT n vol addmsg /kinetics/CaRegulation/CaEPump/Ca-pump-out /kinetics/CaRegulation/CaEPump REAC eA B addmsg /kinetics/CaRegulation/CaEPump/Ca-pump-out /kinetics/CaRegulation/CaEPump CONSERVE nComplex nComplexInit addmsg /kinetics/CaRegulation/CaEPump /kinetics/CaRegulation/CaEPump/Ca-pump-out ENZYME n addmsg /kinetics/Ca /kinetics/CaRegulation/CaEPump/Ca-pump-out SUBSTRATE n addmsg /kinetics/CaRegulation/Ca-leak-from-extracell/Ca-leak-chan /kinetics/CaRegulation/Ca-ext REAC A B addmsg /kinetics/CaRegulation/CaEPump/Ca-pump-out /kinetics/CaRegulation/Ca-ext MM_PRD pA addmsg /kinetics/CaRegulation/capacitive_Ca_entry*/Cap_entry_chan /kinetics/CaRegulation/Ca-ext REAC A B addmsg /kinetics/CaRegulation/Ca-leak-from-extracell /kinetics/CaRegulation/Ca-leak-from-extracell/Ca-leak-chan NUMCHAN n addmsg /kinetics/CaRegulation/Ca-ext /kinetics/CaRegulation/Ca-leak-from-extracell/Ca-leak-chan SUBSTRATE n vol addmsg /kinetics/Ca /kinetics/CaRegulation/Ca-leak-from-extracell/Ca-leak-chan PRODUCT n vol addmsg /kinetics/CaRegulation/inactivate_cap_Ca /kinetics/CaRegulation/capacitive_Ca_entry* REAC A B addmsg /kinetics/CaRegulation/capacitive_Ca_entry* /kinetics/CaRegulation/capacitive_Ca_entry*/Cap_entry_chan NUMCHAN n addmsg /kinetics/CaRegulation/Ca-ext /kinetics/CaRegulation/capacitive_Ca_entry*/Cap_entry_chan SUBSTRATE n vol addmsg /kinetics/Ca /kinetics/CaRegulation/capacitive_Ca_entry*/Cap_entry_chan PRODUCT n vol addmsg /kinetics/CaRegulation/Ca-sequester /kinetics/CaRegulation/inactivate_cap_Ca SUBSTRATE n addmsg /kinetics/CaRegulation/Ca-sequester /kinetics/CaRegulation/inactivate_cap_Ca SUBSTRATE n addmsg /kinetics/CaRegulation/capacitive_Ca_entry* /kinetics/CaRegulation/inactivate_cap_Ca SUBSTRATE n addmsg /kinetics/CaRegulation/inact_cap_entry /kinetics/CaRegulation/inactivate_cap_Ca PRODUCT n addmsg /kinetics/CaRegulation/inactivate_cap_Ca /kinetics/CaRegulation/inact_cap_entry REAC B A addmsg /kinetics/MAPK* /graphs/conc1/MAPK*.Co PLOT Co *MAPK*.Co *orange addmsg /kinetics/PKC-active /graphs/conc1/PKC-active.Co PLOT Co *PKC-active.Co *yellow addmsg /kinetics/EGFR/EGF /graphs/conc2/EGF.Co PLOT Co *EGF.Co *red addmsg /kinetics/EGFR/EGFR /graphs/conc2/EGFR.Co PLOT Co *EGFR.Co *red addmsg /kinetics/PLC_g/Ca.PLC_g* /graphs/conc2/Ca.PLC_g*.Co PLOT Co *Ca.PLC_g*.Co *pink addmsg /kinetics/PLC_g/Ca.PLC_g /graphs/conc2/Ca.PLC_g.Co PLOT Co *Ca.PLC_g.Co *pink addmsg /kinetics/EGFR/SHC* /graphs/conc2/SHC*.Co PLOT Co *SHC*.Co *orange addmsg /kinetics/Sos/Sos /moregraphs/conc3/Sos.Co PLOT Co *Sos.Co *red addmsg /kinetics/Sos/Sos.Grb2 /moregraphs/conc3/Sos.Grb2.Co PLOT Co *Sos.Grb2.Co *orange addmsg /kinetics/Shc*.Sos.Grb2 /moregraphs/conc3/Shc*.Sos.Grb2.Co PLOT Co *Shc*.Sos.Grb2.Co *brown addmsg /kinetics/IP3 /moregraphs/conc4/IP3.Co PLOT Co *IP3.Co *pink addmsg /kinetics/DAG /moregraphs/conc4/DAG.Co PLOT Co *DAG.Co *green enddump // End of dump call /kinetics/doqcsinfo/notes LOAD \ "This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse.
Demonstration script files for generating the figures in the paper, including figure 2, are available here." complete_loading