// DOQCS : http://doqcs.ncbs.res.in/
// Accession Name = fig2_egfr
// Accession Number = 1
// Transcriber = Upinder S. Bhalla, NCBS
// Developer = Upinder S. Bhalla, NCBS
// Species = Generic mammalian
// Tissue = Brain
// Cell Compartment = Surface - Nucleus
// Notes = This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse.
Demonstration script files for generating the figures in the paper, including figure 2, are available here.
//genesis
// kkit Version 11 flat dumpfile
// Saved on Thu Dec 8 12:33:56 2005
include kkit {argv 1}
FASTDT = 0.005
SIMDT = 0.005
CONTROLDT = 1
PLOTDT = 1
MAXTIME = 1000
TRANSIENT_TIME = 2
VARIABLE_DT_FLAG = 0
DEFAULT_VOL = 1.6667e-21
VERSION = 11.0
setfield /file/modpath value /home2/bhalla/scripts/modules
kparms
//genesis
initdump -version 3 -ignoreorphans 1
simobjdump doqcsinfo filename accessname accesstype transcriber developer \
citation species tissue cellcompartment methodology sources \
model_implementation model_validation x y z
simobjdump table input output alloced step_mode stepsize x y z
simobjdump xtree path script namemode sizescale
simobjdump xcoredraw xmin xmax ymin ymax
simobjdump xtext editable
simobjdump xgraph xmin xmax ymin ymax overlay
simobjdump xplot pixflags script fg ysquish do_slope wy
simobjdump group xtree_fg_req xtree_textfg_req plotfield expanded movealone \
link savename file version md5sum mod_save_flag x y z
simobjdump geometry size dim shape outside xtree_fg_req xtree_textfg_req x y \
z
simobjdump kpool DiffConst CoInit Co n nInit mwt nMin vol slave_enable \
geomname xtree_fg_req xtree_textfg_req x y z
simobjdump kreac kf kb notes xtree_fg_req xtree_textfg_req x y z
simobjdump kenz CoComplexInit CoComplex nComplexInit nComplex vol k1 k2 k3 \
keepconc usecomplex notes xtree_fg_req xtree_textfg_req link x y z
simobjdump stim level1 width1 delay1 level2 width2 delay2 baselevel trig_time \
trig_mode notes xtree_fg_req xtree_textfg_req is_running x y z
simobjdump xtab input output alloced step_mode stepsize notes editfunc \
xtree_fg_req xtree_textfg_req baselevel last_x last_y is_running x y z
simobjdump kchan perm gmax Vm is_active use_nernst notes xtree_fg_req \
xtree_textfg_req x y z
simobjdump transport input output alloced step_mode stepsize dt delay clock \
kf xtree_fg_req xtree_textfg_req x y z
simobjdump proto x y z
simundump geometry /kinetics/geometry 0 1e-15 3 sphere "" white black 41 86 0
simundump geometry /kinetics/geometry[1] 0 1.6667e-21 3 sphere "" white black \
0 0 0
simundump geometry /kinetics/geometry[2] 0 1.6e-16 3 sphere "" white black 19 \
42 0
simundump geometry /kinetics/geometry[3] 0 1e-13 3 sphere "" white black 19 \
42 0
simundump geometry /kinetics/geometry[4] 0 1e-15 3 sphere "" white black 19 \
42 0
simundump geometry /kinetics/geometry[5] 0 1.6e-16 3 sphere "" white black 19 \
42 0
simundump geometry /kinetics/geometry[6] 0 1e-13 3 sphere "" white black 19 \
42 0
simundump group /kinetics/PKC 0 blue black x 0 0 "" defaultfile defaultfile.g \
0 0 0 15.951 50.216 0
simundump kpool /kinetics/PKC/PKC-Ca 0 0 3.7208e-17 3.7208e-17 2.2325e-11 \
2.2325e-11 0 0 6e+05 0 /kinetics/geometry[4] red black 14.925 43.511 0
simundump kreac /kinetics/PKC/PKC-act-by-Ca 0 1e-06 0.5 "" white blue 14.925 \
41.877 0
simundump kreac /kinetics/PKC/PKC-act-by-DAG 0 1.3333e-08 8.6348 "" white \
blue 16.939 42.694 0
simundump kreac /kinetics/PKC/PKC-Ca-to-memb 0 1.2705 3.5026 "" white blue \
15.203 46.253 0
simundump kreac /kinetics/PKC/PKC-DAG-to-memb 0 1 0.1 "" white blue 16.383 \
44.736 0
simundump kreac /kinetics/PKC/PKC-act-by-Ca-AA 0 2e-09 0.1 "" white blue \
18.212 45.816 0
simundump kreac /kinetics/PKC/PKC-act-by-DAG-AA 0 2 0.2 "" white blue 20.249 \
45.232 0
simundump kpool /kinetics/PKC/PKC-DAG-AA* 0 0 4.9137e-18 4.9137e-18 \
2.9482e-12 2.9482e-12 0 0 6e+05 0 /kinetics/geometry[4] cyan blue 19.601 \
47.537 0
simundump kpool /kinetics/PKC/PKC-Ca-AA* 0 0 1.75e-16 1.75e-16 1.05e-10 \
1.05e-10 0 0 6e+05 0 /kinetics/geometry[4] orange blue 18.397 48.296 0
simundump kpool /kinetics/PKC/PKC-Ca-memb* 0 0 1.3896e-17 1.3896e-17 \
8.3376e-12 8.3376e-12 0 0 6e+05 0 /kinetics/geometry[4] pink blue 16.221 \
48.529 0
simundump kpool /kinetics/PKC/PKC-DAG-memb* 0 0 9.4352e-21 9.4352e-21 \
5.6611e-15 5.6611e-15 0 0 6e+05 0 /kinetics/geometry[4] yellow blue 17.17 \
47.508 0
simundump kpool /kinetics/PKC/PKC-basal* 0 0 0.02 0.02 12000 12000 0 0 6e+05 \
0 /kinetics/geometry[4] pink blue 14.253 47.566 0
simundump kreac /kinetics/PKC/PKC-basal-act 0 1 50 "" white blue 14.022 \
45.057 0
simundump kpool /kinetics/PKC/PKC-AA* 0 0 1.8133e-17 1.8133e-17 1.088e-11 \
1.088e-11 0 0 6e+05 0 /kinetics/geometry[4] cyan blue 20.782 48.821 0
simundump kreac /kinetics/PKC/PKC-act-by-AA 0 2e-10 0.1 "" white blue 14.007 \
40.135 0
simundump kpool /kinetics/PKC/PKC-Ca-DAG 0 0 8.4632e-23 8.4632e-23 5.0779e-17 \
5.0779e-17 0 0 6e+05 0 /kinetics/geometry[4] white blue 19.231 43.803 0
simundump kreac /kinetics/PKC/PKC-n-DAG 0 1e-09 0.1 "" white blue 15.99 40.01 \
0
simundump kpool /kinetics/PKC/PKC-DAG 0 0 1.161e-16 1.161e-16 6.9661e-11 \
6.9661e-11 0 0 6e+05 0 /kinetics/geometry[4] white blue 18.004 40.914 0
simundump kreac /kinetics/PKC/PKC-n-DAG-AA 0 3e-08 2 "" white blue 17.772 \
39.047 0
simundump kpool /kinetics/PKC/PKC-DAG-AA 0 0 2.5188e-19 2.5188e-19 1.5113e-13 \
1.5113e-13 0 0 6e+05 0 /kinetics/geometry[4] white blue 19.624 42.227 0
simundump kpool /kinetics/PKC/PKC-cytosolic 0 0 1 1 6e+05 6e+05 0 0 6e+05 0 \
/kinetics/geometry[4] white blue 12.868 42.597 0
simundump kpool /kinetics/DAG 1 0 0 0 0 0 0 0 6e+05 0 /kinetics/geometry[4] \
green black 19.718 34.438 0
simundump kpool /kinetics/Ca 1 0 0.08 0.08 48000 48000 0 0 6e+05 0 \
/kinetics/geometry[4] red black 10.613 39.237 0
simundump kpool /kinetics/AA 0 0 0 0 0 0 0 0 6e+05 0 /kinetics/geometry[4] \
darkgreen black 15.71 32.662 0
simundump kpool /kinetics/PKC-active 0 0 2.1222e-16 0.02 12000 12000 0 0 \
6e+05 2 /kinetics/geometry[4] yellow black 21.132 50.477 0
simundump kenz /kinetics/PKC-active/PKC-act-raf 1 0 0 0 0 6e+05 5e-07 16 4 0 \
0 "" red yellow "" 25.253 52.549 0
simundump kenz /kinetics/PKC-active/PKC-inact-GAP 1 0 0 0 0 1 1e-05 16 4 0 0 \
"" red yellow "" 22.439 53.804 0
simundump kenz /kinetics/PKC-active/PKC-act-GEF 1 0 0 0 0 1 1e-05 16 4 0 0 "" \
red yellow "" 18.752 59.264 0
simundump group /kinetics/PLA2 0 darkgreen black x 0 1 "" defaultfile \
defaultfile.g 0 0 0 11.643 27.791 0
simundump kpool /kinetics/PLA2/PLA2-cytosolic 0 0 0.4 0.4 2.4e+05 2.4e+05 0 0 \
6e+05 0 /kinetics/geometry[4] yellow darkgreen 7.176 33.058 0
simundump kreac /kinetics/PLA2/PLA2-Ca-act 0 1.6667e-06 0.1 "" white \
darkgreen 7.903 30.896 0
simundump kpool /kinetics/PLA2/PLA2-Ca* 0 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] yellow darkgreen 10.278 30.354 0
simundump kenz /kinetics/PLA2/PLA2-Ca*/kenz 0 0 0 0 0 6e+05 2.25e-06 21.6 5.4 \
0 0 "" red yellow "" 12.945 30.333 0
simundump kreac /kinetics/PLA2/PIP2-PLA2-act 0 2e-09 0.5 "" white darkgreen \
7.945 35.25 0
simundump kpool /kinetics/PLA2/PIP2-PLA2* 0 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] cyan darkgreen 10.32 35.708 0
simundump kenz /kinetics/PLA2/PIP2-PLA2*/kenz 0 0 0 0 0 6e+05 4.6e-06 44.16 \
11.04 0 0 "" red cyan "" 12.965 35.729 0
simundump kreac /kinetics/PLA2/PIP2-Ca-PLA2-act 0 2e-08 0.1 "" white \
darkgreen 8.903 34.5 0
simundump kpool /kinetics/PLA2/PIP2-Ca-PLA2* 0 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] cyan darkgreen 10.674 34.104 0
simundump kenz /kinetics/PLA2/PIP2-Ca-PLA2*/kenz 0 0 0 0 0 6e+05 1.5e-05 144 \
36 0 0 "" red cyan "" 13.028 34.021 0
simundump kreac /kinetics/PLA2/DAG-Ca-PLA2-act 0 5e-09 4 "" white darkgreen \
8.174 32.166 0
simundump kpool /kinetics/PLA2/DAG-Ca-PLA2* 0 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] pink darkgreen 10.861 31.521 0
simundump kenz /kinetics/PLA2/DAG-Ca-PLA2*/kenz 0 0 0 0 0 6e+05 2.5e-05 240 \
60 0 0 "" red pink "" 13.049 31.646 0
simundump kpool /kinetics/PLA2/APC 0 0 30 30 1.8e+07 1.8e+07 0 0 6e+05 5 \
/kinetics/geometry[4] yellow darkgreen 10.761 32.037 0
simundump kreac /kinetics/PLA2/Degrade-AA 1 0.4 0 "" white darkgreen 12.819 \
36.713 0
simundump kpool /kinetics/PLA2/PLA2*-Ca 0 0 0 0 0 0 0 0 6e+05 1 \
/kinetics/geometry[4] orange darkgreen 11.187 29.313 0
simundump kenz /kinetics/PLA2/PLA2*-Ca/kenz 0 0 0 0 0 6e+05 5e-05 480 120 0 0 \
"" red orange "" 12.919 29.183 0
simundump kpool /kinetics/PLA2/PLA2* 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] orange darkgreen 9.975 27.149 0
simundump kreac /kinetics/PLA2/PLA2*-Ca-act 1 1e-05 0.1 "" white darkgreen \
8.914 29.248 0
simundump kreac /kinetics/PLA2/dephosphorylate-PLA2* 1 0.17 0 "" white \
darkgreen 5.307 30.265 0
simundump kpool /kinetics/MAPK* 1 0 0 0 0 0 0 0 6e+05 0 /kinetics/geometry[4] \
orange yellow 36.453 30.015 0
simundump kenz /kinetics/MAPK*/MAPK* 0 0 0 0 0 6e+05 6.5e-06 80 20 0 0 "" red \
orange "" 6.995 27.06 0
simundump kenz /kinetics/MAPK*/MAPK*-feedback 1 0 0 0 0 6e+05 3.25e-06 40 10 \
0 0 "" red orange "" 29.387 52.668 0
simundump kenz /kinetics/MAPK*/phosph_Sos 1 0 0 0 0 6e+05 3.25e-05 40 10 0 0 \
"" red orange "" 37.458 82.13 0
simundump kpool /kinetics/temp-PIP2 1 0 2.5 2.5 1.5e+06 1.5e+06 0 0 6e+05 6 \
/kinetics/geometry[4] green black 3.204 34.953 0
simundump kpool /kinetics/IP3 1 0 0 0 0 0 0 0 6e+05 0 /kinetics/geometry[4] \
pink black 18.226 37.345 0
simundump kpool /kinetics/Glu 1 0 0 0 0 0 0 0 6e+05 0 /kinetics/geometry[4] \
green black 18.338 55.305 0
simundump group /kinetics/PLCbeta 1 maroon black x 0 0 "" defaultfile \
defaultfile.g 0 0 0 27.585 24.532 0
simundump kreac /kinetics/PLCbeta/Act-PLC-Ca 1 5e-06 1 "" white maroon 22.071 \
25.022 0
simundump kpool /kinetics/PLCbeta/PLC 1 0 0.8 0.8 4.8e+05 4.8e+05 0 0 6e+05 0 \
/kinetics/geometry[4] cyan maroon 29.697 25.043 0
simundump kreac /kinetics/PLCbeta/Degrade-IP3 1 2.5 0 "" white maroon 21.312 \
34.029 0
simundump kpool /kinetics/PLCbeta/Inositol 1 0 0 0 0 0 0 0 6e+05 4 \
/kinetics/geometry[4] green maroon 23.965 33.258 0
simundump kreac /kinetics/PLCbeta/Degrade-DAG 1 0.15 0 "" white maroon 18.043 \
34.739 0
simundump kpool /kinetics/PLCbeta/PC 1 0 0 0 0 0 0 0 1 4 /kinetics/geometry \
green maroon 23.904 34.862 0
simundump kpool /kinetics/PLCbeta/PLC-Ca 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] cyan maroon 26.015 29.203 0
simundump kenz /kinetics/PLCbeta/PLC-Ca/PLC-Ca 1 0 0 0 0 6e+05 4.2e-06 40 10 \
0 0 "" red cyan "" 16.749 30.303 0
simundump kreac /kinetics/PLCbeta/Act-PLC-by-Gq 1 4.2e-05 1 "" white maroon \
21.7 26.837 0
simundump kreac /kinetics/PLCbeta/Inact-PLC-Gq 1 0.0133 0 "" white maroon \
30.125 31.686 0
simundump kpool /kinetics/PLCbeta/PLC-Ca-Gq 0 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] cyan maroon 29.629 28.589 0
simundump kenz /kinetics/PLCbeta/PLC-Ca-Gq/PLCb-Ca-Gq 0 0 0 0 0 6e+05 8e-05 \
192 48 0 0 "" red cyan "" 21.947 30.922 0
simundump kpool /kinetics/PLCbeta/PLC-Gq 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] cyan maroon 34.035 28.463 0
simundump kreac /kinetics/PLCbeta/PLC-bind-Gq 1 4.2e-06 1 "" white maroon \
33.746 25.737 0
simundump kreac /kinetics/PLCbeta/PLC-Gq-bind-Ca 1 5e-05 1 "" white maroon \
33.004 30.746 0
simundump kpool /kinetics/PIP2 1 0 10 10 6e+06 6e+06 0 0 6e+05 4 \
/kinetics/geometry[4] green black 22.884 35.278 0
simundump kpool /kinetics/BetaGamma 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] yellow black 34.787 39.384 0
simundump kpool /kinetics/G*GTP 1 0 0 0 0 0 0 0 6e+05 0 /kinetics/geometry[4] \
red black 26.315 34.987 0
simundump kpool /kinetics/G*GDP 1 0 0 0 0 0 0 0 6e+05 0 /kinetics/geometry[4] \
yellow black 32.56 36.347 0
simundump group /kinetics/Gq 1 blue black x 0 0 "" defaultfile defaultfile.g \
0 0 0 31.745 40.056 0
simundump kreac /kinetics/Gq/RecLigandBinding 1 2.8e-05 10 "" white blue \
26.339 38.821 0
simundump kpool /kinetics/Gq/G-GDP 1 0 1 1 6e+05 6e+05 0 0 6e+05 0 \
/kinetics/geometry[4] yellow blue 29.68 39.427 0
simundump kreac /kinetics/Gq/Basal-Act-G 1 1e-04 0 "" white blue 28.805 \
37.177 0
simundump kreac /kinetics/Gq/Trimerize-G 1 1e-05 0 "" white blue 31.255 \
37.217 0
simundump kreac /kinetics/Gq/Inact-G 1 0.0133 0 "" white blue 29.218 34.39 0
simundump kpool /kinetics/Gq/mGluR 1 0 0.3 0.3 1.8e+05 1.8e+05 0 0 6e+05 0 \
/kinetics/geometry[4] green blue 25.464 40.238 0
simundump kpool /kinetics/Gq/Rec-Glu 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] green blue 24.811 38.278 0
simundump kpool /kinetics/Gq/Rec-Gq 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] green blue 23.077 41.001 0
simundump kreac /kinetics/Gq/Rec-Glu-bind-Gq 1 1e-08 1e-04 "" white blue \
23.715 39.577 0
simundump kreac /kinetics/Gq/Glu-bind-Rec-Gq 1 2.8e-05 0.1 "" white blue \
21.386 38.963 0
simundump kpool /kinetics/Gq/Rec-Glu-Gq 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] orange blue 23.742 36.883 0
simundump kreac /kinetics/Gq/Activate-Gq 1 0.01 0 "" white blue 26.017 37.343 \
0
simundump kreac /kinetics/Gq/Rec-bind-Gq 1 1e-06 1 "" white blue 25.743 \
41.911 0
simundump kpool /kinetics/Gq/mGluRAntag 1 0 0 0 0 0 0 0 6e+05 4 \
/kinetics/geometry[4] seagreen blue 19.602 39.691 0
simundump kreac /kinetics/Gq/Antag-bind-Rec-Gq 1 1e-04 0.01 "" white blue \
21.14 37.719 0
simundump kpool /kinetics/Gq/Blocked-rec-Gq 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] seagreen blue 21.46 36.019 0
simundump group /kinetics/MAPK 0 brown black x 0 0 "" defaultfile \
defaultfile.g 0 0 0 33.616 53.191 0
simundump kpool /kinetics/MAPK/craf-1 0 0 0.2 0.2 1.2e+05 1.2e+05 0 0 6e+05 0 \
/kinetics/geometry[4] pink brown 25.326 50.117 0
simundump kpool /kinetics/MAPK/craf-1* 0 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] pink brown 28.24 49.712 0
simundump kpool /kinetics/MAPK/MAPKK 0 0 0.18 0.18 1.08e+05 1.08e+05 0 0 \
6e+05 0 /kinetics/geometry[4] pink brown 25.332 45.989 0
simundump kpool /kinetics/MAPK/MAPK 0 0 0.36 0.36 2.16e+05 2.16e+05 0 0 6e+05 \
0 /kinetics/geometry[4] pink brown 25.066 43.086 0
simundump kpool /kinetics/MAPK/craf-1** 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] hotpink brown 31.464 49.902 0
simundump kpool /kinetics/MAPK/MAPK-tyr 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] orange brown 27.415 42.82 0
simundump kpool /kinetics/MAPK/MAPKK* 0 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] pink brown 31.548 46.026 0
simundump kenz /kinetics/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 6e+05 2.7e-05 0.6 \
0.15 0 0 "" red pink "" 27.891 45.553 0
simundump kenz /kinetics/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 6e+05 2.7e-05 0.6 \
0.15 0 0 "" red pink "" 31.961 45.036 0
simundump kpool /kinetics/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] pink brown 28.265 46.166 0
simundump kpool /kinetics/MAPK/Raf-GTP-Ras* 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] red brown 23.905 48.781 0
simundump kenz /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.1 1 0 0 0 0 1 5.5e-06 \
0.42 0.105 0 0 "" red red "" 26.618 48.219 0
simundump kenz /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.2 1 0 0 0 0 1 5.5e-06 \
0.42 0.105 0 0 "" red red "" 29.698 48.069 0
simundump kpool /kinetics/MKP-1 1 0 0.0032 0.0032 1920 1920 0 0 6e+05 0 \
/kinetics/geometry[4] hotpink black 24.082 44.441 0
simundump kenz /kinetics/MKP-1/MKP1-tyr-deph 1 0 0 0 0 6e+05 0.000125 4 1 0 0 \
"" red hotpink "" 25.278 45.068 0
simundump kenz /kinetics/MKP-1/MKP1-thr-deph 1 0 0 0 0 6e+05 0.000125 4 1 0 0 \
"" red hotpink "" 29.789 44.931 0
simundump kreac /kinetics/Ras-act-craf 1 4e-05 0.5 "" white black 22.561 \
52.091 0
simundump kpool /kinetics/PPhosphatase2A 1 0 0.224 0.224 1.344e+05 1.344e+05 \
0 0 6e+05 0 /kinetics/geometry[4] hotpink yellow 28.39 51.131 0
simundump kenz /kinetics/PPhosphatase2A/craf-deph 1 0 0 0 0 6e+05 3.3e-06 25 \
6 0 0 "" red hotpink "" 26.801 52.215 0
simundump kenz /kinetics/PPhosphatase2A/MAPKK-deph 1 0 0 0 0 6e+05 3.3e-06 25 \
6 0 0 "" red hotpink "" 32.159 48.074 0
simundump kenz /kinetics/PPhosphatase2A/MAPKK-deph-ser 1 0 0 0 0 6e+05 \
3.3e-06 25 6 0 0 "" red hotpink "" 23.865 47.921 0
simundump kenz /kinetics/PPhosphatase2A/craf**-deph 1 0 0 0 0 1 3.3e-06 25 6 \
0 0 "" red hotpink "" 31.446 51.905 0
simundump group /kinetics/Ras 1 blue black x 0 0 "" defaultfile defaultfile.g \
0 0 0 33.513 58.351 0
simundump kreac /kinetics/Ras/bg-act-GEF 1 1e-05 1 "" white blue 32.468 \
56.838 0
simundump kpool /kinetics/Ras/GEF-Gprot-bg 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] hotpink blue 29.373 59.271 0
simundump kenz /kinetics/Ras/GEF-Gprot-bg/GEF-bg_act-ras 1 0 0 0 0 6e+05 \
3.3e-07 0.08 0.02 0 0 "" red hotpink "" 29.402 58.523 0
simundump kreac /kinetics/Ras/dephosph-GEF 1 1 0 "" white blue 28.07 59.881 0
simundump kpool /kinetics/Ras/inact-GEF 1 0 0.1 0.1 60000 60000 0 0 6e+05 0 \
/kinetics/geometry[4] hotpink blue 31.453 60.352 0
simundump kpool /kinetics/Ras/GEF* 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] hotpink blue 25.448 59.246 0
simundump kenz /kinetics/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 6e+05 3.3e-07 0.08 \
0.02 0 0 "" red hotpink "" 26.085 58.086 0
simundump kpool /kinetics/Ras/GTP-Ras 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] orange blue 31.564 55.084 0
simundump kpool /kinetics/Ras/GDP-Ras 1 0 0.2 0.2 1.2e+05 1.2e+05 0 0 6e+05 0 \
/kinetics/geometry[4] pink blue 25.131 56.165 0
simundump kreac /kinetics/Ras/Ras-intrinsic-GTPase 1 1e-04 0 "" white blue \
28.098 55.5 0
simundump kreac /kinetics/Ras/dephosph-GAP 1 0.1 0 "" white blue 23.023 \
57.524 0
simundump kpool /kinetics/Ras/GAP* 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] red blue 20.35 56.349 0
simundump kpool /kinetics/Ras/GAP 1 0 0.002 0.002 1200 1200 0 0 6e+05 0 \
/kinetics/geometry[4] red blue 25.655 54.338 0
simundump kenz /kinetics/Ras/GAP/GAP-inact-ras 1 0 0 0 0 6e+05 0.001666 1000 \
10 0 0 "" red red "" 28.012 54.403 0
simundump kpool /kinetics/Ras/inact-GEF* 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] hotpink blue 34.029 61.16 0
simundump kreac /kinetics/Ras/CaM-bind-GEF 1 1e-04 1 "" white blue 21.486 \
63.679 0
simundump kpool /kinetics/Ras/CaM-GEF 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] pink blue 24.345 61.58 0
simundump kenz /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 0 0 6e+05 3.3e-07 \
0.08 0.02 0 0 "" red pink "" 24.022 60.657 0
simundump kreac /kinetics/Ras/dephosph-inact-GEF* 1 1 0 "" white blue 33.431 \
63.995 0
simundump kpool /kinetics/PKA-active 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] yellow black 28.587 64.519 0
simundump kenz /kinetics/PKA-active/PKA-phosph-GEF 1 0 0 0 0 6e+05 1e-05 36 9 \
0 0 "" red yellow "" 29.464 63.469 0
simundump kpool /kinetics/CaM-Ca4 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] blue black 17.382 63.931 0
simundump kpool /kinetics/Shc*.Sos.Grb2 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] brown yellow 30.263 69.112 0
simundump kenz /kinetics/Shc*.Sos.Grb2/Sos.Ras_GEF 1 0 0 0 0 6e+05 3.3e-07 \
0.08 0.02 0 0 "" red brown "" 30.266 66.47 0
simundump group /kinetics/EGFR 1 yellow black x 0 0 "" defaultfile \
defaultfile.g 0 0 0 26.025 81.57 0
simundump kpool /kinetics/EGFR/EGFR 1 0 0.16667 0.16667 1e+05 1e+05 0 0 6e+05 \
0 /kinetics/geometry[4] red yellow 20.955 81.853 0
simundump kreac /kinetics/EGFR/act_EGFR 1 7e-06 0.25 "" white yellow 23.489 \
80.493 0
simundump kpool /kinetics/EGFR/L.EGFR 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] red yellow 25.219 78.599 0
simundump kenz /kinetics/EGFR/L.EGFR/phosph_PLC_g 1 0 0 0 0 6e+05 5e-06 0.8 \
0.2 0 0 "" red red "" 25.336 77.082 0
simundump kenz /kinetics/EGFR/L.EGFR/phosph_Shc 1 0 0 0 0 6e+05 2e-06 0.8 0.2 \
0 0 "" red red "" 28.033 78.49 0
simundump kpool /kinetics/EGFR/EGF 1 0 0 0 0 0 0 0 6e+05 4 \
/kinetics/geometry[4] red yellow 21.272 78.309 0
simundump kpool /kinetics/EGFR/SHC 1 0 0.5 0.5 3e+05 3e+05 0 0 6e+05 0 \
/kinetics/geometry[4] orange yellow 27.386 75.936 0
simundump kpool /kinetics/EGFR/SHC* 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] orange yellow 31.832 75.029 0
simundump kreac /kinetics/EGFR/dephosph_Shc 1 0.0016667 0 "" white yellow \
28.737 73.442 0
simundump kpool /kinetics/EGFR/Internal_L.EGFR 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] red yellow 25.306 83.93 0
simundump kreac /kinetics/EGFR/Internalize 1 0.002 0.00033 "" white yellow \
23.521 81.863 0
simundump group /kinetics/Sos 1 blue black x 0 0 "" defaultfile defaultfile.g \
0 0 0 38.547 76.811 0
simundump kreac /kinetics/Sos/Shc_bind_Sos.Grb2 1 8.333e-07 0.1 "" white blue \
29.23 71.891 0
simundump kpool /kinetics/Sos/Sos*.Grb2 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] orange blue 31.274 83.661 0
simundump kreac /kinetics/Sos/Grb2_bind_Sos* 1 4.1667e-08 0.0168 "" white \
blue 29.533 80.235 0
simundump kpool /kinetics/Sos/Grb2 1 0 1 1 6e+05 6e+05 0 0 6e+05 0 \
/kinetics/geometry[4] orange blue 33.742 77.301 0
simundump kpool /kinetics/Sos/Sos.Grb2 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] orange blue 32.988 72.097 0
simundump kpool /kinetics/Sos/Sos* 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] red blue 34.421 82.215 0
simundump kreac /kinetics/Sos/dephosph_Sos 1 0.001 0 "" white blue 32.185 \
79.153 0
simundump kreac /kinetics/Sos/Grb2_bind_Sos 1 4.1667e-08 0.0168 "" white blue \
35.422 75.133 0
simundump kpool /kinetics/Sos/Sos 1 0 0.1 0.1 60000 60000 0 0 6e+05 0 \
/kinetics/geometry[4] red blue 36.381 78.794 0
simundump group /kinetics/PLC_g 1 darkgreen black x 0 0 "" defaultfile \
defaultfile.g 0 0 0 19.45 75.831 0
simundump kpool /kinetics/PLC_g/PLC_g 1 0 0.82 0.82 4.92e+05 4.92e+05 0 0 \
6e+05 0 /kinetics/geometry[4] pink darkgreen 19.08 73.598 0
simundump kreac /kinetics/PLC_g/Ca_act_PLC_g 1 0.0003 10 "" white darkgreen \
17.555 70.194 0
simundump kreac /kinetics/PLC_g/Ca_act_PLC_g* 1 2e-05 10 "" white darkgreen \
21.79 71.8 0
simundump kreac /kinetics/PLC_g/dephosph_PLC_g 1 0.05 0 "" white darkgreen \
23.559 74.225 0
simundump kpool /kinetics/PLC_g/PLC_G* 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] pink darkgreen 26.139 73.319 0
simundump kpool /kinetics/PLC_g/Ca.PLC_g 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] pink darkgreen 21.1 69.462 0
simundump kenz /kinetics/PLC_g/Ca.PLC_g/PIP2_hydrolysis 1 0 0 0 0 6e+05 \
1.2e-06 56 14 0 1 "" red pink "" 18.235 41.647 0
simundump kpool /kinetics/PLC_g/Ca.PLC_g* 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] pink darkgreen 26.109 68.972 0
simundump kenz /kinetics/PLC_g/Ca.PLC_g*/PIP2_hydrolysis 1 0 0 0 0 6e+05 \
2.4e-05 228 57 0 1 "" red pink "" 22.507 39.968 0
simundump group /kinetics/CaRegulation 1 darkgreen black x 0 0 "" defaultfile \
defaultfile.g 0 0 0 6.224 67.684 0
simundump kreac /kinetics/CaRegulation/CaTraspATPase 1 25 0 "" white \
darkgreen 10.379 61.527 0
simundump kpool /kinetics/CaRegulation/Ca-sequester 1 0 6.3328 6.3328 \
6.0795e+05 6.0795e+05 0 0 96000 0 /kinetics/geometry[5] red darkgreen 7.577 \
64.374 0
simundump kpool /kinetics/CaRegulation/Ca-leak-to-cytoplasm 1 0 0.001 0.001 \
600 600 0 0 6e+05 5 /kinetics/geometry[4] pink darkgreen 12.773 65.855 0
simundump kchan /kinetics/CaRegulation/Ca-leak-to-cytoplasm/Ca-leak-chan 1 8 \
0.1 0 1 0 "" brown pink 12.734 64.875 0
simundump kpool /kinetics/CaRegulation/CaTransp-2Ca 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] pink darkgreen 11.61 63.068 0
simundump kpool /kinetics/CaRegulation/CaTransp 1 0 0.01 0.01 6000 6000 0 0 \
6e+05 0 /kinetics/geometry[4] pink darkgreen 8.708 62.51 0
simundump kreac /kinetics/CaRegulation/Ca-bind-to-Transp 1 1e-08 144 "" white \
darkgreen 9.7846 63.913 0
simundump kpool /kinetics/CaRegulation/IP3R 1 0 0.01667 0.01667 10002 10002 0 \
0 6e+05 0 /kinetics/geometry[4] green darkgreen 7.282 55.924 0
simundump kreac /kinetics/CaRegulation/IP3Rbind 1 1e-20 1 "" white darkgreen \
7.528 58.014 0
simundump kpool /kinetics/CaRegulation/IP3R* 1 0 0 0 0 0 0 0 6e+05 0 \
/kinetics/geometry[4] green darkgreen 6.987 59.832 0
simundump kchan /kinetics/CaRegulation/IP3R*/IP3chan 1 19.2 0.1 0 1 0 "" \
brown green 7.697 60.718 0
simundump kpool /kinetics/CaRegulation/CaEPump 1 0 0.00083333 0.00083333 500 \
500 0 0 6e+05 0 /kinetics/geometry[4] pink darkgreen 10.652 69.289 0
simundump kenz /kinetics/CaRegulation/CaEPump/Ca-pump-out 1 0 0 0 0 6e+05 \
0.003 288 72 0 0 "" red pink "" 13.347 67.909 0
simundump kpool /kinetics/CaRegulation/Ca-ext 1 0 4000 4000 2.4e+11 2.4e+11 0 \
0 6e+07 4 /kinetics/geometry[6] red darkgreen 10.24 70.77 0
simundump kpool /kinetics/CaRegulation/Ca-leak-from-extracell 1 0 0.00083333 \
0.00083333 500 500 0 0 6e+05 0 /kinetics/geometry[4] hotpink darkgreen 7.02 \
71.228 0
simundump kchan /kinetics/CaRegulation/Ca-leak-from-extracell/Ca-leak-chan 1 \
0.004 0.1 0 1 0 "" brown hotpink 8.331 69.411 0
simundump kpool /kinetics/CaRegulation/capacitive_Ca_entry* 1 0 0.00083333 \
0.00083333 500 500 0 0 6e+05 0 /kinetics/geometry[4] hotpink darkgreen \
3.209 69.52 0
simundump kchan /kinetics/CaRegulation/capacitive_Ca_entry*/Cap_entry_chan 1 \
0.005 0.1 0 1 0 "" brown hotpink 6.365 69.303 0
simundump kreac /kinetics/CaRegulation/inactivate_cap_Ca 1 1.2e-11 1 "" white \
darkgreen 3.328 67.27 0
simundump kpool /kinetics/CaRegulation/inact_cap_entry 1 0 0 0 0 0 0 0 6e+05 \
0 /kinetics/geometry[4] pink darkgreen 3.119 64.314 0
simundump doqcsinfo /kinetics/doqcsinfo 0 db1.g fig2_egfr network \
"Upinder S. Bhalla, NCBS" "Upinder S. Bhalla, NCBS" "citation here" \
"Generic Mammalian" Brain "Surface - Nucleus" \
"Quantitative match to experiments, Hypothetical" \
"Bhalla US and Iyengar R. Science (1999) 283(5400):381-7(Peer-reviewed publication ), Peer-reviewed publication, Peer-reviewed publication" \
"Exact GENESIS implementation" \
"Approximates original data , Quantitatively predicts new data" 41 89 0
simundump xgraph /graphs/conc1 0 0 10000 0 0.007 0
simundump xgraph /graphs/conc2 0 0 10000 0 0.1 0
simundump xplot /graphs/conc1/MAPK*.Co 3 524288 \
"delete_plot.w ; edit_plot.D " orange 0 0 1
simundump xplot /graphs/conc1/PKC-active.Co 3 524288 \
"delete_plot.w ; edit_plot.D " yellow 0 0 1
simundump xplot /graphs/conc2/EGF.Co 3 524288 \
"delete_plot.w ; edit_plot.D " red 0 0 1
simundump xplot /graphs/conc2/EGFR.Co 3 524288 \
"delete_plot.w ; edit_plot.D " red 0 0 1
simundump xplot /graphs/conc2/Ca.PLC_g*.Co 3 524288 \
"delete_plot.w ; edit_plot.D " pink 0 0 1
simundump xplot /graphs/conc2/Ca.PLC_g.Co 3 524288 \
"delete_plot.w ; edit_plot.D " pink 0 0 1
simundump xplot /graphs/conc2/SHC*.Co 3 524288 \
"delete_plot.w ; edit_plot.D " orange 0 0 1
simundump xgraph /moregraphs/conc3 0 0 10000 0.0020844 0.1 0
simundump xgraph /moregraphs/conc4 0 143.8 10000 -0.067568 20 0
simundump xplot /moregraphs/conc3/Sos.Co 3 524288 \
"delete_plot.w ; edit_plot.D " red 0 0 1
simundump xplot /moregraphs/conc3/Sos.Grb2.Co 3 524288 \
"delete_plot.w ; edit_plot.D " orange 0 0 1
simundump xplot /moregraphs/conc3/Shc*.Sos.Grb2.Co 3 524288 \
"delete_plot.w ; edit_plot.D " brown 0 0 1
simundump xplot /moregraphs/conc4/IP3.Co 3 524288 \
"delete_plot.w ; edit_plot.D " pink 0 0 1
simundump xplot /moregraphs/conc4/DAG.Co 3 524288 \
"delete_plot.w ; edit_plot.D " green 0 0 1
simundump xcoredraw /edit/draw 0 -2 43 -2 91
simundump xtree /edit/draw/tree 0 \
/kinetics/#[],/kinetics/#[]/#[],/kinetics/#[]/#[]/#[][TYPE!=proto],/kinetics/#[]/#[]/#[][TYPE!=linkinfo]/##[] \
"edit_elm.D ; drag_from_edit.w " auto 0.6
simundump xtext /file/notes 0 1
xtextload /file/notes \
"Merged:" \
"PKC45, PLA50, PLC_Gq61, MAPK77," \
"ras8, simple_egf424" \
"and added enz reac for Sos.Ras_GEF" \
"on GDP ras giving GTP-ras." \
"Added some plots on top." \
"Eliminated notes for portability."
addmsg /kinetics/PKC/PKC-act-by-Ca /kinetics/PKC/PKC-Ca REAC B A
addmsg /kinetics/PKC/PKC-act-by-DAG /kinetics/PKC/PKC-Ca REAC A B
addmsg /kinetics/PKC/PKC-Ca-to-memb /kinetics/PKC/PKC-Ca REAC A B
addmsg /kinetics/PKC/PKC-act-by-Ca-AA /kinetics/PKC/PKC-Ca REAC A B
addmsg /kinetics/PKC/PKC-cytosolic /kinetics/PKC/PKC-act-by-Ca SUBSTRATE n
addmsg /kinetics/Ca /kinetics/PKC/PKC-act-by-Ca SUBSTRATE n
addmsg /kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-act-by-Ca PRODUCT n
addmsg /kinetics/DAG /kinetics/PKC/PKC-act-by-DAG SUBSTRATE n
addmsg /kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-act-by-DAG SUBSTRATE n
addmsg /kinetics/PKC/PKC-Ca-DAG /kinetics/PKC/PKC-act-by-DAG PRODUCT n
addmsg /kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-Ca-to-memb SUBSTRATE n
addmsg /kinetics/PKC/PKC-Ca-memb* /kinetics/PKC/PKC-Ca-to-memb PRODUCT n
addmsg /kinetics/PKC/PKC-Ca-DAG /kinetics/PKC/PKC-DAG-to-memb SUBSTRATE n
addmsg /kinetics/PKC/PKC-DAG-memb* /kinetics/PKC/PKC-DAG-to-memb PRODUCT n
addmsg /kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-act-by-Ca-AA SUBSTRATE n
addmsg /kinetics/AA /kinetics/PKC/PKC-act-by-Ca-AA SUBSTRATE n
addmsg /kinetics/PKC/PKC-Ca-AA* /kinetics/PKC/PKC-act-by-Ca-AA PRODUCT n
addmsg /kinetics/PKC/PKC-DAG-AA* /kinetics/PKC/PKC-act-by-DAG-AA PRODUCT n
addmsg /kinetics/PKC/PKC-DAG-AA /kinetics/PKC/PKC-act-by-DAG-AA SUBSTRATE n
addmsg /kinetics/PKC/PKC-act-by-DAG-AA /kinetics/PKC/PKC-DAG-AA* REAC B A
addmsg /kinetics/PKC/PKC-act-by-Ca-AA /kinetics/PKC/PKC-Ca-AA* REAC B A
addmsg /kinetics/PKC/PKC-Ca-to-memb /kinetics/PKC/PKC-Ca-memb* REAC B A
addmsg /kinetics/PKC/PKC-DAG-to-memb /kinetics/PKC/PKC-DAG-memb* REAC B A
addmsg /kinetics/PKC/PKC-basal-act /kinetics/PKC/PKC-basal* REAC B A
addmsg /kinetics/PKC/PKC-cytosolic /kinetics/PKC/PKC-basal-act SUBSTRATE n
addmsg /kinetics/PKC/PKC-basal* /kinetics/PKC/PKC-basal-act PRODUCT n
addmsg /kinetics/PKC/PKC-act-by-AA /kinetics/PKC/PKC-AA* REAC B A
addmsg /kinetics/AA /kinetics/PKC/PKC-act-by-AA SUBSTRATE n
addmsg /kinetics/PKC/PKC-AA* /kinetics/PKC/PKC-act-by-AA PRODUCT n
addmsg /kinetics/PKC/PKC-cytosolic /kinetics/PKC/PKC-act-by-AA SUBSTRATE n
addmsg /kinetics/PKC/PKC-act-by-DAG /kinetics/PKC/PKC-Ca-DAG REAC B A
addmsg /kinetics/PKC/PKC-DAG-to-memb /kinetics/PKC/PKC-Ca-DAG REAC A B
addmsg /kinetics/PKC/PKC-cytosolic /kinetics/PKC/PKC-n-DAG SUBSTRATE n
addmsg /kinetics/DAG /kinetics/PKC/PKC-n-DAG SUBSTRATE n
addmsg /kinetics/PKC/PKC-DAG /kinetics/PKC/PKC-n-DAG PRODUCT n
addmsg /kinetics/PKC/PKC-n-DAG /kinetics/PKC/PKC-DAG REAC B A
addmsg /kinetics/PKC/PKC-n-DAG-AA /kinetics/PKC/PKC-DAG REAC A B
addmsg /kinetics/PKC/PKC-DAG /kinetics/PKC/PKC-n-DAG-AA SUBSTRATE n
addmsg /kinetics/AA /kinetics/PKC/PKC-n-DAG-AA SUBSTRATE n
addmsg /kinetics/PKC/PKC-DAG-AA /kinetics/PKC/PKC-n-DAG-AA PRODUCT n
addmsg /kinetics/PKC/PKC-n-DAG-AA /kinetics/PKC/PKC-DAG-AA REAC B A
addmsg /kinetics/PKC/PKC-act-by-DAG-AA /kinetics/PKC/PKC-DAG-AA REAC A B
addmsg /kinetics/PKC/PKC-act-by-Ca /kinetics/PKC/PKC-cytosolic REAC A B
addmsg /kinetics/PKC/PKC-basal-act /kinetics/PKC/PKC-cytosolic REAC A B
addmsg /kinetics/PKC/PKC-act-by-AA /kinetics/PKC/PKC-cytosolic REAC A B
addmsg /kinetics/PKC/PKC-n-DAG /kinetics/PKC/PKC-cytosolic REAC A B
addmsg /kinetics/PKC/PKC-act-by-DAG /kinetics/DAG REAC A B
addmsg /kinetics/PKC/PKC-n-DAG /kinetics/DAG REAC A B
addmsg /kinetics/PLA2/DAG-Ca-PLA2-act /kinetics/DAG REAC A B
addmsg /kinetics/PLCbeta/PLC-Ca-Gq/PLCb-Ca-Gq /kinetics/DAG MM_PRD pA
addmsg /kinetics/PLCbeta/Degrade-DAG /kinetics/DAG REAC A B
addmsg /kinetics/PLCbeta/PLC-Ca/PLC-Ca /kinetics/DAG MM_PRD pA
addmsg /kinetics/PLC_g/Ca.PLC_g/PIP2_hydrolysis /kinetics/DAG MM_PRD pA
addmsg /kinetics/PLC_g/Ca.PLC_g*/PIP2_hydrolysis /kinetics/DAG MM_PRD pA
addmsg /kinetics/PKC/PKC-act-by-Ca /kinetics/Ca REAC A B
addmsg /kinetics/PLA2/PLA2-Ca-act /kinetics/Ca REAC A B
addmsg /kinetics/PLA2/PLA2*-Ca-act /kinetics/Ca REAC A B
addmsg /kinetics/PLCbeta/Act-PLC-Ca /kinetics/Ca REAC A B
addmsg /kinetics/PLCbeta/PLC-Gq-bind-Ca /kinetics/Ca REAC A B
addmsg /kinetics/PLC_g/Ca_act_PLC_g /kinetics/Ca REAC A B
addmsg /kinetics/PLC_g/Ca_act_PLC_g* /kinetics/Ca REAC A B
addmsg /kinetics/CaRegulation/Ca-bind-to-Transp /kinetics/Ca REAC A B
addmsg /kinetics/CaRegulation/Ca-bind-to-Transp /kinetics/Ca REAC A B
addmsg /kinetics/CaRegulation/IP3R*/IP3chan /kinetics/Ca REAC B A
addmsg /kinetics/CaRegulation/Ca-leak-to-cytoplasm/Ca-leak-chan /kinetics/Ca REAC B A
addmsg /kinetics/CaRegulation/Ca-leak-from-extracell/Ca-leak-chan /kinetics/Ca REAC B A
addmsg /kinetics/CaRegulation/CaEPump/Ca-pump-out /kinetics/Ca REAC sA B
addmsg /kinetics/CaRegulation/capacitive_Ca_entry*/Cap_entry_chan /kinetics/Ca REAC B A
addmsg /kinetics/PKC/PKC-act-by-Ca-AA /kinetics/AA REAC A B
addmsg /kinetics/PKC/PKC-act-by-AA /kinetics/AA REAC A B
addmsg /kinetics/PKC/PKC-n-DAG-AA /kinetics/AA REAC A B
addmsg /kinetics/PLA2/PLA2-Ca*/kenz /kinetics/AA MM_PRD pA
addmsg /kinetics/PLA2/PIP2-PLA2*/kenz /kinetics/AA MM_PRD pA
addmsg /kinetics/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/AA MM_PRD pA
addmsg /kinetics/PLA2/DAG-Ca-PLA2*/kenz /kinetics/AA MM_PRD pA
addmsg /kinetics/PLA2/PLA2*-Ca/kenz /kinetics/AA MM_PRD pA
addmsg /kinetics/PLA2/Degrade-AA /kinetics/AA REAC A B
addmsg /kinetics/PKC/PKC-DAG-AA* /kinetics/PKC-active SUMTOTAL n nInit
addmsg /kinetics/PKC/PKC-Ca-memb* /kinetics/PKC-active SUMTOTAL n nInit
addmsg /kinetics/PKC/PKC-Ca-AA* /kinetics/PKC-active SUMTOTAL n nInit
addmsg /kinetics/PKC/PKC-DAG-memb* /kinetics/PKC-active SUMTOTAL n nInit
addmsg /kinetics/PKC/PKC-basal* /kinetics/PKC-active SUMTOTAL n nInit
addmsg /kinetics/PKC/PKC-AA* /kinetics/PKC-active SUMTOTAL n nInit
addmsg /kinetics/PKC-active/PKC-act-raf /kinetics/PKC-active CONSERVE nComplex nComplexInit
addmsg /kinetics/PKC-active/PKC-inact-GAP /kinetics/PKC-active REAC eA B
addmsg /kinetics/PKC-active/PKC-inact-GAP /kinetics/PKC-active CONSERVE nComplex nComplexInit
addmsg /kinetics/PKC-active/PKC-act-GEF /kinetics/PKC-active REAC eA B
addmsg /kinetics/PKC-active/PKC-act-GEF /kinetics/PKC-active CONSERVE nComplex nComplexInit
addmsg /kinetics/PKC-active/PKC-act-raf /kinetics/PKC-active REAC eA B
addmsg /kinetics/PKC-active /kinetics/PKC-active/PKC-act-raf ENZYME n
addmsg /kinetics/MAPK/craf-1 /kinetics/PKC-active/PKC-act-raf SUBSTRATE n
addmsg /kinetics/PKC-active /kinetics/PKC-active/PKC-inact-GAP ENZYME n
addmsg /kinetics/Ras/GAP /kinetics/PKC-active/PKC-inact-GAP SUBSTRATE n
addmsg /kinetics/PKC-active /kinetics/PKC-active/PKC-act-GEF ENZYME n
addmsg /kinetics/Ras/inact-GEF /kinetics/PKC-active/PKC-act-GEF SUBSTRATE n
addmsg /kinetics/PLA2/PLA2-Ca-act /kinetics/PLA2/PLA2-cytosolic REAC A B
addmsg /kinetics/PLA2/PIP2-PLA2-act /kinetics/PLA2/PLA2-cytosolic REAC A B
addmsg /kinetics/PLA2/PIP2-PLA2* /kinetics/PLA2/PLA2-cytosolic CONSERVE n nInit
addmsg /kinetics/PLA2/PIP2-Ca-PLA2* /kinetics/PLA2/PLA2-cytosolic CONSERVE n nInit
addmsg /kinetics/PLA2/DAG-Ca-PLA2* /kinetics/PLA2/PLA2-cytosolic CONSERVE n nInit
addmsg /kinetics/PLA2/PLA2-Ca* /kinetics/PLA2/PLA2-cytosolic CONSERVE n nInit
addmsg /kinetics/PLA2/PLA2*-Ca /kinetics/PLA2/PLA2-cytosolic CONSERVE n nInit
addmsg /kinetics/MAPK*/MAPK* /kinetics/PLA2/PLA2-cytosolic CONSERVE nComplex nComplexInit
addmsg /kinetics/PLA2/PLA2*-Ca/kenz /kinetics/PLA2/PLA2-cytosolic CONSERVE nComplex nComplexInit
addmsg /kinetics/PLA2/PLA2-Ca*/kenz /kinetics/PLA2/PLA2-cytosolic CONSERVE nComplex nComplexInit
addmsg /kinetics/PLA2/DAG-Ca-PLA2*/kenz /kinetics/PLA2/PLA2-cytosolic CONSERVE nComplex nComplexInit
addmsg /kinetics/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/PLA2/PLA2-cytosolic CONSERVE nComplex nComplexInit
addmsg /kinetics/PLA2/PIP2-PLA2*/kenz /kinetics/PLA2/PLA2-cytosolic CONSERVE nComplex nComplexInit
addmsg /kinetics/MAPK*/MAPK* /kinetics/PLA2/PLA2-cytosolic REAC sA B
addmsg /kinetics/PLA2/PLA2* /kinetics/PLA2/PLA2-cytosolic CONSERVE n nInit
addmsg /kinetics/PLA2/dephosphorylate-PLA2* /kinetics/PLA2/PLA2-cytosolic REAC B A
addmsg /kinetics/PLA2/PLA2-cytosolic /kinetics/PLA2/PLA2-Ca-act SUBSTRATE n
addmsg /kinetics/Ca /kinetics/PLA2/PLA2-Ca-act SUBSTRATE n
addmsg /kinetics/PLA2/PLA2-Ca* /kinetics/PLA2/PLA2-Ca-act PRODUCT n
addmsg /kinetics/PLA2/PLA2-Ca-act /kinetics/PLA2/PLA2-Ca* REAC B A
addmsg /kinetics/PLA2/PLA2-Ca*/kenz /kinetics/PLA2/PLA2-Ca* REAC eA B
addmsg /kinetics/PLA2/PIP2-Ca-PLA2-act /kinetics/PLA2/PLA2-Ca* REAC A B
addmsg /kinetics/PLA2/DAG-Ca-PLA2-act /kinetics/PLA2/PLA2-Ca* REAC A B
addmsg /kinetics/PLA2/PLA2-Ca* /kinetics/PLA2/PLA2-Ca*/kenz ENZYME n
addmsg /kinetics/PLA2/APC /kinetics/PLA2/PLA2-Ca*/kenz SUBSTRATE n
addmsg /kinetics/temp-PIP2 /kinetics/PLA2/PIP2-PLA2-act SUBSTRATE n
addmsg /kinetics/PLA2/PLA2-cytosolic /kinetics/PLA2/PIP2-PLA2-act SUBSTRATE n
addmsg /kinetics/PLA2/PIP2-PLA2* /kinetics/PLA2/PIP2-PLA2-act PRODUCT n
addmsg /kinetics/PLA2/PIP2-PLA2-act /kinetics/PLA2/PIP2-PLA2* REAC B A
addmsg /kinetics/PLA2/PIP2-PLA2*/kenz /kinetics/PLA2/PIP2-PLA2* REAC eA B
addmsg /kinetics/PLA2/PIP2-PLA2* /kinetics/PLA2/PIP2-PLA2*/kenz ENZYME n
addmsg /kinetics/PLA2/APC /kinetics/PLA2/PIP2-PLA2*/kenz SUBSTRATE n
addmsg /kinetics/temp-PIP2 /kinetics/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n
addmsg /kinetics/PLA2/PLA2-Ca* /kinetics/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n
addmsg /kinetics/PLA2/PIP2-Ca-PLA2* /kinetics/PLA2/PIP2-Ca-PLA2-act PRODUCT n
addmsg /kinetics/PLA2/PIP2-Ca-PLA2-act /kinetics/PLA2/PIP2-Ca-PLA2* REAC B A
addmsg /kinetics/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/PLA2/PIP2-Ca-PLA2* REAC eA B
addmsg /kinetics/PLA2/PIP2-Ca-PLA2* /kinetics/PLA2/PIP2-Ca-PLA2*/kenz ENZYME n
addmsg /kinetics/PLA2/APC /kinetics/PLA2/PIP2-Ca-PLA2*/kenz SUBSTRATE n
addmsg /kinetics/DAG /kinetics/PLA2/DAG-Ca-PLA2-act SUBSTRATE n
addmsg /kinetics/PLA2/PLA2-Ca* /kinetics/PLA2/DAG-Ca-PLA2-act SUBSTRATE n
addmsg /kinetics/PLA2/DAG-Ca-PLA2* /kinetics/PLA2/DAG-Ca-PLA2-act PRODUCT n
addmsg /kinetics/PLA2/DAG-Ca-PLA2-act /kinetics/PLA2/DAG-Ca-PLA2* REAC B A
addmsg /kinetics/PLA2/DAG-Ca-PLA2*/kenz /kinetics/PLA2/DAG-Ca-PLA2* REAC eA B
addmsg /kinetics/PLA2/DAG-Ca-PLA2* /kinetics/PLA2/DAG-Ca-PLA2*/kenz ENZYME n
addmsg /kinetics/PLA2/APC /kinetics/PLA2/DAG-Ca-PLA2*/kenz SUBSTRATE n
addmsg /kinetics/PLA2/PLA2-Ca*/kenz /kinetics/PLA2/APC REAC sA B
addmsg /kinetics/PLA2/PIP2-PLA2*/kenz /kinetics/PLA2/APC REAC sA B
addmsg /kinetics/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/PLA2/APC REAC sA B
addmsg /kinetics/PLA2/DAG-Ca-PLA2*/kenz /kinetics/PLA2/APC REAC sA B
addmsg /kinetics/PLA2/PLA2*-Ca/kenz /kinetics/PLA2/APC REAC sA B
addmsg /kinetics/PLA2/Degrade-AA /kinetics/PLA2/APC REAC B A
addmsg /kinetics/AA /kinetics/PLA2/Degrade-AA SUBSTRATE n
addmsg /kinetics/PLA2/APC /kinetics/PLA2/Degrade-AA PRODUCT n
addmsg /kinetics/PLA2/PLA2*-Ca/kenz /kinetics/PLA2/PLA2*-Ca REAC eA B
addmsg /kinetics/PLA2/PLA2*-Ca-act /kinetics/PLA2/PLA2*-Ca REAC B A
addmsg /kinetics/PLA2/PLA2*-Ca /kinetics/PLA2/PLA2*-Ca/kenz ENZYME n
addmsg /kinetics/PLA2/APC /kinetics/PLA2/PLA2*-Ca/kenz SUBSTRATE n
addmsg /kinetics/MAPK*/MAPK* /kinetics/PLA2/PLA2* MM_PRD pA
addmsg /kinetics/PLA2/PLA2*-Ca-act /kinetics/PLA2/PLA2* REAC A B
addmsg /kinetics/PLA2/dephosphorylate-PLA2* /kinetics/PLA2/PLA2* REAC A B
addmsg /kinetics/PLA2/PLA2* /kinetics/PLA2/PLA2*-Ca-act SUBSTRATE n
addmsg /kinetics/PLA2/PLA2*-Ca /kinetics/PLA2/PLA2*-Ca-act PRODUCT n
addmsg /kinetics/Ca /kinetics/PLA2/PLA2*-Ca-act SUBSTRATE n
addmsg /kinetics/PLA2/PLA2* /kinetics/PLA2/dephosphorylate-PLA2* SUBSTRATE n
addmsg /kinetics/PLA2/PLA2-cytosolic /kinetics/PLA2/dephosphorylate-PLA2* PRODUCT n
addmsg /kinetics/MAPK*/MAPK* /kinetics/MAPK* REAC eA B
addmsg /kinetics/MAPK*/MAPK*-feedback /kinetics/MAPK* REAC eA B
addmsg /kinetics/MAPK/MAPKK*/MAPKKthr /kinetics/MAPK* MM_PRD pA
addmsg /kinetics/MKP-1/MKP1-thr-deph /kinetics/MAPK* REAC sA B
addmsg /kinetics/MAPK*/phosph_Sos /kinetics/MAPK* REAC eA B
addmsg /kinetics/MAPK* /kinetics/MAPK*/MAPK* ENZYME n
addmsg /kinetics/PLA2/PLA2-cytosolic /kinetics/MAPK*/MAPK* SUBSTRATE n
addmsg /kinetics/MAPK* /kinetics/MAPK*/MAPK*-feedback ENZYME n
addmsg /kinetics/MAPK/craf-1* /kinetics/MAPK*/MAPK*-feedback SUBSTRATE n
addmsg /kinetics/MAPK* /kinetics/MAPK*/phosph_Sos ENZYME n
addmsg /kinetics/Sos/Sos /kinetics/MAPK*/phosph_Sos SUBSTRATE n
addmsg /kinetics/PLA2/PIP2-PLA2-act /kinetics/temp-PIP2 REAC A B
addmsg /kinetics/PLA2/PIP2-Ca-PLA2-act /kinetics/temp-PIP2 REAC A B
addmsg /kinetics/PLCbeta/PLC-Ca-Gq/PLCb-Ca-Gq /kinetics/IP3 MM_PRD pA
addmsg /kinetics/PLCbeta/Degrade-IP3 /kinetics/IP3 REAC A B
addmsg /kinetics/PLCbeta/PLC-Ca/PLC-Ca /kinetics/IP3 MM_PRD pA
addmsg /kinetics/PLC_g/Ca.PLC_g/PIP2_hydrolysis /kinetics/IP3 MM_PRD pA
addmsg /kinetics/PLC_g/Ca.PLC_g*/PIP2_hydrolysis /kinetics/IP3 MM_PRD pA
addmsg /kinetics/CaRegulation/IP3Rbind /kinetics/IP3 REAC A B
addmsg /kinetics/CaRegulation/IP3Rbind /kinetics/IP3 REAC A B
addmsg /kinetics/CaRegulation/IP3Rbind /kinetics/IP3 REAC A B
addmsg /kinetics/Gq/RecLigandBinding /kinetics/Glu REAC A B
addmsg /kinetics/Gq/Glu-bind-Rec-Gq /kinetics/Glu REAC A B
addmsg /kinetics/Ca /kinetics/PLCbeta/Act-PLC-Ca SUBSTRATE n
addmsg /kinetics/PLCbeta/PLC /kinetics/PLCbeta/Act-PLC-Ca SUBSTRATE n
addmsg /kinetics/PLCbeta/PLC-Ca /kinetics/PLCbeta/Act-PLC-Ca PRODUCT n
addmsg /kinetics/PLCbeta/PLC-Ca-Gq /kinetics/PLCbeta/PLC CONSERVE n nInit
addmsg /kinetics/PLCbeta/PLC-Ca-Gq/PLCb-Ca-Gq /kinetics/PLCbeta/PLC CONSERVE nComplex nComplexInit
addmsg /kinetics/PLCbeta/Act-PLC-Ca /kinetics/PLCbeta/PLC REAC A B
addmsg /kinetics/PLCbeta/PLC-Ca /kinetics/PLCbeta/PLC CONSERVE n nInit
addmsg /kinetics/PLCbeta/PLC-Ca/PLC-Ca /kinetics/PLCbeta/PLC CONSERVE nComplex nComplexInit
addmsg /kinetics/PLCbeta/PLC-bind-Gq /kinetics/PLCbeta/PLC REAC A B
addmsg /kinetics/PLCbeta/PLC-Gq /kinetics/PLCbeta/PLC CONSERVE n nInit
addmsg /kinetics/IP3 /kinetics/PLCbeta/Degrade-IP3 SUBSTRATE n
addmsg /kinetics/PLCbeta/Inositol /kinetics/PLCbeta/Degrade-IP3 PRODUCT n
addmsg /kinetics/PLCbeta/Degrade-IP3 /kinetics/PLCbeta/Inositol REAC B A
addmsg /kinetics/PLCbeta/PC /kinetics/PLCbeta/Degrade-DAG PRODUCT n
addmsg /kinetics/DAG /kinetics/PLCbeta/Degrade-DAG SUBSTRATE n
addmsg /kinetics/PLCbeta/Degrade-DAG /kinetics/PLCbeta/PC REAC B A
addmsg /kinetics/PLCbeta/Act-PLC-Ca /kinetics/PLCbeta/PLC-Ca REAC B A
addmsg /kinetics/PLCbeta/Act-PLC-by-Gq /kinetics/PLCbeta/PLC-Ca REAC A B
addmsg /kinetics/PLCbeta/Inact-PLC-Gq /kinetics/PLCbeta/PLC-Ca REAC B A
addmsg /kinetics/PLCbeta/PLC-Ca/PLC-Ca /kinetics/PLCbeta/PLC-Ca REAC eA B
addmsg /kinetics/PLCbeta/PLC-Ca /kinetics/PLCbeta/PLC-Ca/PLC-Ca ENZYME n
addmsg /kinetics/PIP2 /kinetics/PLCbeta/PLC-Ca/PLC-Ca SUBSTRATE n
addmsg /kinetics/G*GTP /kinetics/PLCbeta/Act-PLC-by-Gq SUBSTRATE n
addmsg /kinetics/PLCbeta/PLC-Ca /kinetics/PLCbeta/Act-PLC-by-Gq SUBSTRATE n
addmsg /kinetics/PLCbeta/PLC-Ca-Gq /kinetics/PLCbeta/Act-PLC-by-Gq PRODUCT n
addmsg /kinetics/G*GDP /kinetics/PLCbeta/Inact-PLC-Gq PRODUCT n
addmsg /kinetics/PLCbeta/PLC-Ca-Gq /kinetics/PLCbeta/Inact-PLC-Gq SUBSTRATE n
addmsg /kinetics/PLCbeta/PLC-Ca /kinetics/PLCbeta/Inact-PLC-Gq PRODUCT n
addmsg /kinetics/PLCbeta/PLC-Ca-Gq/PLCb-Ca-Gq /kinetics/PLCbeta/PLC-Ca-Gq REAC eA B
addmsg /kinetics/PLCbeta/Act-PLC-by-Gq /kinetics/PLCbeta/PLC-Ca-Gq REAC B A
addmsg /kinetics/PLCbeta/Inact-PLC-Gq /kinetics/PLCbeta/PLC-Ca-Gq REAC A B
addmsg /kinetics/PLCbeta/PLC-Gq-bind-Ca /kinetics/PLCbeta/PLC-Ca-Gq REAC B A
addmsg /kinetics/PLCbeta/PLC-Ca-Gq /kinetics/PLCbeta/PLC-Ca-Gq/PLCb-Ca-Gq ENZYME n
addmsg /kinetics/PIP2 /kinetics/PLCbeta/PLC-Ca-Gq/PLCb-Ca-Gq SUBSTRATE n
addmsg /kinetics/PLCbeta/PLC-bind-Gq /kinetics/PLCbeta/PLC-Gq REAC B A
addmsg /kinetics/PLCbeta/PLC-Gq-bind-Ca /kinetics/PLCbeta/PLC-Gq REAC A B
addmsg /kinetics/PLCbeta/PLC /kinetics/PLCbeta/PLC-bind-Gq SUBSTRATE n
addmsg /kinetics/G*GTP /kinetics/PLCbeta/PLC-bind-Gq SUBSTRATE n
addmsg /kinetics/PLCbeta/PLC-Gq /kinetics/PLCbeta/PLC-bind-Gq PRODUCT n
addmsg /kinetics/Ca /kinetics/PLCbeta/PLC-Gq-bind-Ca SUBSTRATE n
addmsg /kinetics/PLCbeta/PLC-Gq /kinetics/PLCbeta/PLC-Gq-bind-Ca SUBSTRATE n
addmsg /kinetics/PLCbeta/PLC-Ca-Gq /kinetics/PLCbeta/PLC-Gq-bind-Ca PRODUCT n
addmsg /kinetics/PLCbeta/PLC-Ca-Gq/PLCb-Ca-Gq /kinetics/PIP2 REAC sA B
addmsg /kinetics/PLCbeta/PLC-Ca/PLC-Ca /kinetics/PIP2 REAC sA B
addmsg /kinetics/PLC_g/Ca.PLC_g*/PIP2_hydrolysis /kinetics/PIP2 REAC sA B
addmsg /kinetics/PLC_g/Ca.PLC_g/PIP2_hydrolysis /kinetics/PIP2 REAC sA B
addmsg /kinetics/Gq/Trimerize-G /kinetics/BetaGamma REAC A B
addmsg /kinetics/Gq/Basal-Act-G /kinetics/BetaGamma REAC B A
addmsg /kinetics/Gq/Activate-Gq /kinetics/BetaGamma REAC B A
addmsg /kinetics/Ras/bg-act-GEF /kinetics/BetaGamma REAC A B
addmsg /kinetics/PLCbeta/Act-PLC-by-Gq /kinetics/G*GTP REAC A B
addmsg /kinetics/PLCbeta/PLC-bind-Gq /kinetics/G*GTP REAC A B
addmsg /kinetics/Gq/Inact-G /kinetics/G*GTP REAC A B
addmsg /kinetics/Gq/Basal-Act-G /kinetics/G*GTP REAC B A
addmsg /kinetics/Gq/Activate-Gq /kinetics/G*GTP REAC B A
addmsg /kinetics/PLCbeta/Inact-PLC-Gq /kinetics/G*GDP REAC B A
addmsg /kinetics/Gq/Inact-G /kinetics/G*GDP REAC B A
addmsg /kinetics/Gq/Trimerize-G /kinetics/G*GDP REAC A B
addmsg /kinetics/Gq/mGluR /kinetics/Gq/RecLigandBinding SUBSTRATE n
addmsg /kinetics/Glu /kinetics/Gq/RecLigandBinding SUBSTRATE n
addmsg /kinetics/Gq/Rec-Glu /kinetics/Gq/RecLigandBinding PRODUCT n
addmsg /kinetics/Gq/Trimerize-G /kinetics/Gq/G-GDP REAC B A
addmsg /kinetics/Gq/Basal-Act-G /kinetics/Gq/G-GDP REAC A B
addmsg /kinetics/Gq/Rec-Glu-bind-Gq /kinetics/Gq/G-GDP REAC A B
addmsg /kinetics/Gq/Rec-bind-Gq /kinetics/Gq/G-GDP REAC A B
addmsg /kinetics/Gq/G-GDP /kinetics/Gq/Basal-Act-G SUBSTRATE n
addmsg /kinetics/G*GTP /kinetics/Gq/Basal-Act-G PRODUCT n
addmsg /kinetics/BetaGamma /kinetics/Gq/Basal-Act-G PRODUCT n
addmsg /kinetics/G*GDP /kinetics/Gq/Trimerize-G SUBSTRATE n
addmsg /kinetics/BetaGamma /kinetics/Gq/Trimerize-G SUBSTRATE n
addmsg /kinetics/Gq/G-GDP /kinetics/Gq/Trimerize-G PRODUCT n
addmsg /kinetics/G*GTP /kinetics/Gq/Inact-G SUBSTRATE n
addmsg /kinetics/G*GDP /kinetics/Gq/Inact-G PRODUCT n
addmsg /kinetics/Gq/RecLigandBinding /kinetics/Gq/mGluR REAC A B
addmsg /kinetics/Gq/Rec-Glu /kinetics/Gq/mGluR CONSERVE n nInit
addmsg /kinetics/Gq/Rec-Glu-Gq /kinetics/Gq/mGluR CONSERVE n nInit
addmsg /kinetics/Gq/Rec-Gq /kinetics/Gq/mGluR CONSERVE n nInit
addmsg /kinetics/Gq/Rec-bind-Gq /kinetics/Gq/mGluR REAC A B
addmsg /kinetics/Gq/Blocked-rec-Gq /kinetics/Gq/mGluR CONSERVE n nInit
addmsg /kinetics/Gq/RecLigandBinding /kinetics/Gq/Rec-Glu REAC B A
addmsg /kinetics/Gq/Rec-Glu-bind-Gq /kinetics/Gq/Rec-Glu REAC A B
addmsg /kinetics/Gq/Activate-Gq /kinetics/Gq/Rec-Glu REAC B A
addmsg /kinetics/Gq/Glu-bind-Rec-Gq /kinetics/Gq/Rec-Gq REAC A B
addmsg /kinetics/Gq/Rec-bind-Gq /kinetics/Gq/Rec-Gq REAC B A
addmsg /kinetics/Gq/Antag-bind-Rec-Gq /kinetics/Gq/Rec-Gq REAC A B
addmsg /kinetics/Gq/G-GDP /kinetics/Gq/Rec-Glu-bind-Gq SUBSTRATE n
addmsg /kinetics/Gq/Rec-Glu /kinetics/Gq/Rec-Glu-bind-Gq SUBSTRATE n
addmsg /kinetics/Gq/Rec-Glu-Gq /kinetics/Gq/Rec-Glu-bind-Gq PRODUCT n
addmsg /kinetics/Glu /kinetics/Gq/Glu-bind-Rec-Gq SUBSTRATE n
addmsg /kinetics/Gq/Rec-Glu-Gq /kinetics/Gq/Glu-bind-Rec-Gq PRODUCT n
addmsg /kinetics/Gq/Rec-Gq /kinetics/Gq/Glu-bind-Rec-Gq SUBSTRATE n
addmsg /kinetics/Gq/Rec-Glu-bind-Gq /kinetics/Gq/Rec-Glu-Gq REAC B A
addmsg /kinetics/Gq/Glu-bind-Rec-Gq /kinetics/Gq/Rec-Glu-Gq REAC B A
addmsg /kinetics/Gq/Activate-Gq /kinetics/Gq/Rec-Glu-Gq REAC A B
addmsg /kinetics/Gq/Rec-Glu-Gq /kinetics/Gq/Activate-Gq SUBSTRATE n
addmsg /kinetics/G*GTP /kinetics/Gq/Activate-Gq PRODUCT n
addmsg /kinetics/BetaGamma /kinetics/Gq/Activate-Gq PRODUCT n
addmsg /kinetics/Gq/Rec-Glu /kinetics/Gq/Activate-Gq PRODUCT n
addmsg /kinetics/Gq/G-GDP /kinetics/Gq/Rec-bind-Gq SUBSTRATE n
addmsg /kinetics/Gq/mGluR /kinetics/Gq/Rec-bind-Gq SUBSTRATE n
addmsg /kinetics/Gq/Rec-Gq /kinetics/Gq/Rec-bind-Gq PRODUCT n
addmsg /kinetics/Gq/Antag-bind-Rec-Gq /kinetics/Gq/mGluRAntag REAC A B
addmsg /kinetics/Gq/Rec-Gq /kinetics/Gq/Antag-bind-Rec-Gq SUBSTRATE n
addmsg /kinetics/Gq/mGluRAntag /kinetics/Gq/Antag-bind-Rec-Gq SUBSTRATE n
addmsg /kinetics/Gq/Blocked-rec-Gq /kinetics/Gq/Antag-bind-Rec-Gq PRODUCT n
addmsg /kinetics/Gq/Antag-bind-Rec-Gq /kinetics/Gq/Blocked-rec-Gq REAC B A
addmsg /kinetics/PKC-active/PKC-act-raf /kinetics/MAPK/craf-1 REAC sA B
addmsg /kinetics/PPhosphatase2A/craf-deph /kinetics/MAPK/craf-1 MM_PRD pA
addmsg /kinetics/PKC-active/PKC-act-raf /kinetics/MAPK/craf-1* MM_PRD pA
addmsg /kinetics/MAPK*/MAPK*-feedback /kinetics/MAPK/craf-1* REAC sA B
addmsg /kinetics/PPhosphatase2A/craf-deph /kinetics/MAPK/craf-1* REAC sA B
addmsg /kinetics/PPhosphatase2A/craf**-deph /kinetics/MAPK/craf-1* MM_PRD pA
addmsg /kinetics/Ras-act-craf /kinetics/MAPK/craf-1* REAC A B
addmsg /kinetics/PPhosphatase2A/MAPKK-deph-ser /kinetics/MAPK/MAPKK MM_PRD pA
addmsg /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.1 /kinetics/MAPK/MAPKK REAC sA B
addmsg /kinetics/MAPK/MAPKK*/MAPKKtyr /kinetics/MAPK/MAPK REAC sA B
addmsg /kinetics/MKP-1/MKP1-tyr-deph /kinetics/MAPK/MAPK MM_PRD pA
addmsg /kinetics/MAPK*/MAPK*-feedback /kinetics/MAPK/craf-1** MM_PRD pA
addmsg /kinetics/PPhosphatase2A/craf**-deph /kinetics/MAPK/craf-1** REAC sA B
addmsg /kinetics/MAPK/MAPKK*/MAPKKtyr /kinetics/MAPK/MAPK-tyr MM_PRD pA
addmsg /kinetics/MAPK/MAPKK*/MAPKKthr /kinetics/MAPK/MAPK-tyr REAC sA B
addmsg /kinetics/MKP-1/MKP1-tyr-deph /kinetics/MAPK/MAPK-tyr REAC sA B
addmsg /kinetics/MKP-1/MKP1-thr-deph /kinetics/MAPK/MAPK-tyr MM_PRD pA
addmsg /kinetics/MAPK/MAPKK*/MAPKKtyr /kinetics/MAPK/MAPKK* REAC eA B
addmsg /kinetics/MAPK/MAPKK*/MAPKKthr /kinetics/MAPK/MAPKK* REAC eA B
addmsg /kinetics/PPhosphatase2A/MAPKK-deph /kinetics/MAPK/MAPKK* REAC sA B
addmsg /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.2 /kinetics/MAPK/MAPKK* MM_PRD pA
addmsg /kinetics/MAPK/MAPKK* /kinetics/MAPK/MAPKK*/MAPKKtyr ENZYME n
addmsg /kinetics/MAPK/MAPK /kinetics/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n
addmsg /kinetics/MAPK/MAPKK* /kinetics/MAPK/MAPKK*/MAPKKthr ENZYME n
addmsg /kinetics/MAPK/MAPK-tyr /kinetics/MAPK/MAPKK*/MAPKKthr SUBSTRATE n
addmsg /kinetics/PPhosphatase2A/MAPKK-deph /kinetics/MAPK/MAPKK-ser MM_PRD pA
addmsg /kinetics/PPhosphatase2A/MAPKK-deph-ser /kinetics/MAPK/MAPKK-ser REAC sA B
addmsg /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.1 /kinetics/MAPK/MAPKK-ser MM_PRD pA
addmsg /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.2 /kinetics/MAPK/MAPKK-ser REAC sA B
addmsg /kinetics/Ras-act-craf /kinetics/MAPK/Raf-GTP-Ras* REAC B A
addmsg /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.1 /kinetics/MAPK/Raf-GTP-Ras* REAC eA B
addmsg /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.2 /kinetics/MAPK/Raf-GTP-Ras* REAC eA B
addmsg /kinetics/MAPK/Raf-GTP-Ras* /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.1 ENZYME n
addmsg /kinetics/MAPK/MAPKK /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.1 SUBSTRATE n
addmsg /kinetics/MAPK/Raf-GTP-Ras* /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.2 ENZYME n
addmsg /kinetics/MAPK/MAPKK-ser /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.2 SUBSTRATE n
addmsg /kinetics/MKP-1/MKP1-tyr-deph /kinetics/MKP-1 REAC eA B
addmsg /kinetics/MKP-1/MKP1-thr-deph /kinetics/MKP-1 REAC eA B
addmsg /kinetics/MKP-1 /kinetics/MKP-1/MKP1-tyr-deph ENZYME n
addmsg /kinetics/MAPK/MAPK-tyr /kinetics/MKP-1/MKP1-tyr-deph SUBSTRATE n
addmsg /kinetics/MKP-1 /kinetics/MKP-1/MKP1-thr-deph ENZYME n
addmsg /kinetics/MAPK* /kinetics/MKP-1/MKP1-thr-deph SUBSTRATE n
addmsg /kinetics/MAPK/Raf-GTP-Ras* /kinetics/Ras-act-craf PRODUCT n
addmsg /kinetics/MAPK/craf-1* /kinetics/Ras-act-craf SUBSTRATE n
addmsg /kinetics/Ras/GTP-Ras /kinetics/Ras-act-craf SUBSTRATE n
addmsg /kinetics/PPhosphatase2A/craf-deph /kinetics/PPhosphatase2A REAC eA B
addmsg /kinetics/PPhosphatase2A/MAPKK-deph /kinetics/PPhosphatase2A REAC eA B
addmsg /kinetics/PPhosphatase2A/MAPKK-deph-ser /kinetics/PPhosphatase2A REAC eA B
addmsg /kinetics/PPhosphatase2A/craf**-deph /kinetics/PPhosphatase2A REAC eA B
addmsg /kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/craf-deph ENZYME n
addmsg /kinetics/MAPK/craf-1* /kinetics/PPhosphatase2A/craf-deph SUBSTRATE n
addmsg /kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/MAPKK-deph ENZYME n
addmsg /kinetics/MAPK/MAPKK* /kinetics/PPhosphatase2A/MAPKK-deph SUBSTRATE n
addmsg /kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/MAPKK-deph-ser ENZYME n
addmsg /kinetics/MAPK/MAPKK-ser /kinetics/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n
addmsg /kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/craf**-deph ENZYME n
addmsg /kinetics/MAPK/craf-1** /kinetics/PPhosphatase2A/craf**-deph SUBSTRATE n
addmsg /kinetics/BetaGamma /kinetics/Ras/bg-act-GEF SUBSTRATE n
addmsg /kinetics/Ras/inact-GEF /kinetics/Ras/bg-act-GEF SUBSTRATE n
addmsg /kinetics/Ras/GEF-Gprot-bg /kinetics/Ras/bg-act-GEF PRODUCT n
addmsg /kinetics/Ras/GEF-Gprot-bg/GEF-bg_act-ras /kinetics/Ras/GEF-Gprot-bg REAC eA B
addmsg /kinetics/Ras/bg-act-GEF /kinetics/Ras/GEF-Gprot-bg REAC B A
addmsg /kinetics/Ras/GEF-Gprot-bg /kinetics/Ras/GEF-Gprot-bg/GEF-bg_act-ras ENZYME n
addmsg /kinetics/Ras/GDP-Ras /kinetics/Ras/GEF-Gprot-bg/GEF-bg_act-ras SUBSTRATE n
addmsg /kinetics/Ras/GEF* /kinetics/Ras/dephosph-GEF SUBSTRATE n
addmsg /kinetics/Ras/inact-GEF /kinetics/Ras/dephosph-GEF PRODUCT n
addmsg /kinetics/Ras/bg-act-GEF /kinetics/Ras/inact-GEF REAC A B
addmsg /kinetics/PKC-active/PKC-act-GEF /kinetics/Ras/inact-GEF REAC sA B
addmsg /kinetics/Ras/dephosph-GEF /kinetics/Ras/inact-GEF REAC B A
addmsg /kinetics/PKA-active/PKA-phosph-GEF /kinetics/Ras/inact-GEF REAC sA B
addmsg /kinetics/Ras/CaM-bind-GEF /kinetics/Ras/inact-GEF REAC A B
addmsg /kinetics/Ras/dephosph-inact-GEF* /kinetics/Ras/inact-GEF REAC B A
addmsg /kinetics/PKC-active/PKC-act-GEF /kinetics/Ras/GEF* MM_PRD pA
addmsg /kinetics/Ras/dephosph-GEF /kinetics/Ras/GEF* REAC A B
addmsg /kinetics/Ras/GEF*/GEF*-act-ras /kinetics/Ras/GEF* REAC eA B
addmsg /kinetics/Ras/GEF* /kinetics/Ras/GEF*/GEF*-act-ras ENZYME n
addmsg /kinetics/Ras/GDP-Ras /kinetics/Ras/GEF*/GEF*-act-ras SUBSTRATE n
addmsg /kinetics/Ras/GEF-Gprot-bg/GEF-bg_act-ras /kinetics/Ras/GTP-Ras MM_PRD pA
addmsg /kinetics/Ras/GAP/GAP-inact-ras /kinetics/Ras/GTP-Ras REAC sA B
addmsg /kinetics/Ras/Ras-intrinsic-GTPase /kinetics/Ras/GTP-Ras REAC A B
addmsg /kinetics/Ras/GEF*/GEF*-act-ras /kinetics/Ras/GTP-Ras MM_PRD pA
addmsg /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/Ras/GTP-Ras MM_PRD pA
addmsg /kinetics/Ras-act-craf /kinetics/Ras/GTP-Ras REAC A B
addmsg /kinetics/Shc*.Sos.Grb2/Sos.Ras_GEF /kinetics/Ras/GTP-Ras MM_PRD pA
addmsg /kinetics/Ras/GEF-Gprot-bg/GEF-bg_act-ras /kinetics/Ras/GDP-Ras REAC sA B
addmsg /kinetics/Ras/GAP/GAP-inact-ras /kinetics/Ras/GDP-Ras MM_PRD pA
addmsg /kinetics/Ras/Ras-intrinsic-GTPase /kinetics/Ras/GDP-Ras REAC B A
addmsg /kinetics/Ras/GEF*/GEF*-act-ras /kinetics/Ras/GDP-Ras REAC sA B
addmsg /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/Ras/GDP-Ras REAC sA B
addmsg /kinetics/Shc*.Sos.Grb2/Sos.Ras_GEF /kinetics/Ras/GDP-Ras REAC sA B
addmsg /kinetics/Ras/GTP-Ras /kinetics/Ras/Ras-intrinsic-GTPase SUBSTRATE n
addmsg /kinetics/Ras/GDP-Ras /kinetics/Ras/Ras-intrinsic-GTPase PRODUCT n
addmsg /kinetics/Ras/GAP* /kinetics/Ras/dephosph-GAP SUBSTRATE n
addmsg /kinetics/Ras/GAP /kinetics/Ras/dephosph-GAP PRODUCT n
addmsg /kinetics/PKC-active/PKC-inact-GAP /kinetics/Ras/GAP* MM_PRD pA
addmsg /kinetics/Ras/dephosph-GAP /kinetics/Ras/GAP* REAC A B
addmsg /kinetics/Ras/GAP/GAP-inact-ras /kinetics/Ras/GAP REAC eA B
addmsg /kinetics/PKC-active/PKC-inact-GAP /kinetics/Ras/GAP REAC sA B
addmsg /kinetics/Ras/dephosph-GAP /kinetics/Ras/GAP REAC B A
addmsg /kinetics/Ras/GAP /kinetics/Ras/GAP/GAP-inact-ras ENZYME n
addmsg /kinetics/Ras/GTP-Ras /kinetics/Ras/GAP/GAP-inact-ras SUBSTRATE n
addmsg /kinetics/PKA-active/PKA-phosph-GEF /kinetics/Ras/inact-GEF* MM_PRD pA
addmsg /kinetics/Ras/dephosph-inact-GEF* /kinetics/Ras/inact-GEF* REAC A B
addmsg /kinetics/Ras/inact-GEF /kinetics/Ras/CaM-bind-GEF SUBSTRATE n
addmsg /kinetics/Ras/CaM-GEF /kinetics/Ras/CaM-bind-GEF PRODUCT n
addmsg /kinetics/CaM-Ca4 /kinetics/Ras/CaM-bind-GEF SUBSTRATE n
addmsg /kinetics/Ras/CaM-bind-GEF /kinetics/Ras/CaM-GEF REAC B A
addmsg /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/Ras/CaM-GEF REAC eA B
addmsg /kinetics/Ras/CaM-GEF /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n
addmsg /kinetics/Ras/GDP-Ras /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n
addmsg /kinetics/Ras/inact-GEF* /kinetics/Ras/dephosph-inact-GEF* SUBSTRATE n
addmsg /kinetics/Ras/inact-GEF /kinetics/Ras/dephosph-inact-GEF* PRODUCT n
addmsg /kinetics/PKA-active/PKA-phosph-GEF /kinetics/PKA-active REAC eA B
addmsg /kinetics/PKA-active /kinetics/PKA-active/PKA-phosph-GEF ENZYME n
addmsg /kinetics/Ras/inact-GEF /kinetics/PKA-active/PKA-phosph-GEF SUBSTRATE n
addmsg /kinetics/Ras/CaM-bind-GEF /kinetics/CaM-Ca4 REAC A B
addmsg /kinetics/Sos/Shc_bind_Sos.Grb2 /kinetics/Shc*.Sos.Grb2 REAC B A
addmsg /kinetics/Shc*.Sos.Grb2/Sos.Ras_GEF /kinetics/Shc*.Sos.Grb2 REAC eA B
addmsg /kinetics/Shc*.Sos.Grb2 /kinetics/Shc*.Sos.Grb2/Sos.Ras_GEF ENZYME n
addmsg /kinetics/Ras/GDP-Ras /kinetics/Shc*.Sos.Grb2/Sos.Ras_GEF SUBSTRATE n
addmsg /kinetics/EGFR/act_EGFR /kinetics/EGFR/EGFR REAC A B
addmsg /kinetics/EGFR/EGFR /kinetics/EGFR/act_EGFR SUBSTRATE n
addmsg /kinetics/EGFR/EGF /kinetics/EGFR/act_EGFR SUBSTRATE n
addmsg /kinetics/EGFR/L.EGFR /kinetics/EGFR/act_EGFR PRODUCT n
addmsg /kinetics/EGFR/act_EGFR /kinetics/EGFR/L.EGFR REAC B A
addmsg /kinetics/EGFR/L.EGFR/phosph_PLC_g /kinetics/EGFR/L.EGFR REAC eA B
addmsg /kinetics/EGFR/L.EGFR/phosph_Shc /kinetics/EGFR/L.EGFR REAC eA B
addmsg /kinetics/EGFR/Internalize /kinetics/EGFR/L.EGFR REAC A B
addmsg /kinetics/EGFR/L.EGFR /kinetics/EGFR/L.EGFR/phosph_PLC_g ENZYME n
addmsg /kinetics/PLC_g/Ca.PLC_g /kinetics/EGFR/L.EGFR/phosph_PLC_g SUBSTRATE n
addmsg /kinetics/EGFR/L.EGFR /kinetics/EGFR/L.EGFR/phosph_Shc ENZYME n
addmsg /kinetics/EGFR/SHC /kinetics/EGFR/L.EGFR/phosph_Shc SUBSTRATE n
addmsg /kinetics/EGFR/act_EGFR /kinetics/EGFR/EGF REAC A B
addmsg /kinetics/EGFR/dephosph_Shc /kinetics/EGFR/SHC REAC B A
addmsg /kinetics/EGFR/L.EGFR/phosph_Shc /kinetics/EGFR/SHC REAC sA B
addmsg /kinetics/EGFR/dephosph_Shc /kinetics/EGFR/SHC* REAC A B
addmsg /kinetics/Sos/Shc_bind_Sos.Grb2 /kinetics/EGFR/SHC* REAC A B
addmsg /kinetics/EGFR/L.EGFR/phosph_Shc /kinetics/EGFR/SHC* MM_PRD pA
addmsg /kinetics/EGFR/SHC* /kinetics/EGFR/dephosph_Shc SUBSTRATE n
addmsg /kinetics/EGFR/SHC /kinetics/EGFR/dephosph_Shc PRODUCT n
addmsg /kinetics/EGFR/Internalize /kinetics/EGFR/Internal_L.EGFR REAC B A
addmsg /kinetics/EGFR/L.EGFR /kinetics/EGFR/Internalize SUBSTRATE n
addmsg /kinetics/EGFR/Internal_L.EGFR /kinetics/EGFR/Internalize PRODUCT n
addmsg /kinetics/Sos/Sos.Grb2 /kinetics/Sos/Shc_bind_Sos.Grb2 SUBSTRATE n
addmsg /kinetics/EGFR/SHC* /kinetics/Sos/Shc_bind_Sos.Grb2 SUBSTRATE n
addmsg /kinetics/Shc*.Sos.Grb2 /kinetics/Sos/Shc_bind_Sos.Grb2 PRODUCT n
addmsg /kinetics/Sos/Grb2_bind_Sos* /kinetics/Sos/Sos*.Grb2 REAC B A
addmsg /kinetics/Sos/Sos* /kinetics/Sos/Grb2_bind_Sos* SUBSTRATE n
addmsg /kinetics/Sos/Grb2 /kinetics/Sos/Grb2_bind_Sos* SUBSTRATE n
addmsg /kinetics/Sos/Sos*.Grb2 /kinetics/Sos/Grb2_bind_Sos* PRODUCT n
addmsg /kinetics/Sos/Grb2_bind_Sos /kinetics/Sos/Grb2 REAC A B
addmsg /kinetics/Sos/Grb2_bind_Sos* /kinetics/Sos/Grb2 REAC A B
addmsg /kinetics/Sos/Grb2_bind_Sos /kinetics/Sos/Sos.Grb2 REAC B A
addmsg /kinetics/Sos/Shc_bind_Sos.Grb2 /kinetics/Sos/Sos.Grb2 REAC A B
addmsg /kinetics/MAPK*/phosph_Sos /kinetics/Sos/Sos* MM_PRD pA
addmsg /kinetics/Sos/Grb2_bind_Sos* /kinetics/Sos/Sos* REAC A B
addmsg /kinetics/Sos/dephosph_Sos /kinetics/Sos/Sos* REAC A B
addmsg /kinetics/Sos/Sos* /kinetics/Sos/dephosph_Sos SUBSTRATE n
addmsg /kinetics/Sos/Sos /kinetics/Sos/dephosph_Sos PRODUCT n
addmsg /kinetics/Sos/Grb2 /kinetics/Sos/Grb2_bind_Sos SUBSTRATE n
addmsg /kinetics/Sos/Sos.Grb2 /kinetics/Sos/Grb2_bind_Sos PRODUCT n
addmsg /kinetics/Sos/Sos /kinetics/Sos/Grb2_bind_Sos SUBSTRATE n
addmsg /kinetics/Sos/Grb2_bind_Sos /kinetics/Sos/Sos REAC A B
addmsg /kinetics/MAPK*/phosph_Sos /kinetics/Sos/Sos REAC sA B
addmsg /kinetics/Sos/dephosph_Sos /kinetics/Sos/Sos REAC B A
addmsg /kinetics/PLC_g/Ca_act_PLC_g /kinetics/PLC_g/PLC_g REAC A B
addmsg /kinetics/PLC_g/PLC_g /kinetics/PLC_g/Ca_act_PLC_g SUBSTRATE n
addmsg /kinetics/Ca /kinetics/PLC_g/Ca_act_PLC_g SUBSTRATE n
addmsg /kinetics/PLC_g/Ca.PLC_g /kinetics/PLC_g/Ca_act_PLC_g PRODUCT n
addmsg /kinetics/Ca /kinetics/PLC_g/Ca_act_PLC_g* SUBSTRATE n
addmsg /kinetics/PLC_g/PLC_G* /kinetics/PLC_g/Ca_act_PLC_g* SUBSTRATE n
addmsg /kinetics/PLC_g/Ca.PLC_g* /kinetics/PLC_g/Ca_act_PLC_g* PRODUCT n
addmsg /kinetics/PLC_g/Ca.PLC_g* /kinetics/PLC_g/dephosph_PLC_g SUBSTRATE n
addmsg /kinetics/PLC_g/Ca.PLC_g /kinetics/PLC_g/dephosph_PLC_g PRODUCT n
addmsg /kinetics/PLC_g/Ca_act_PLC_g* /kinetics/PLC_g/PLC_G* REAC A B
addmsg /kinetics/PLC_g/Ca_act_PLC_g /kinetics/PLC_g/Ca.PLC_g REAC B A
addmsg /kinetics/EGFR/L.EGFR/phosph_PLC_g /kinetics/PLC_g/Ca.PLC_g REAC sA B
addmsg /kinetics/PLC_g/dephosph_PLC_g /kinetics/PLC_g/Ca.PLC_g REAC B A
addmsg /kinetics/PLC_g/Ca.PLC_g /kinetics/PLC_g/Ca.PLC_g/PIP2_hydrolysis ENZYME n
addmsg /kinetics/PIP2 /kinetics/PLC_g/Ca.PLC_g/PIP2_hydrolysis SUBSTRATE n
addmsg /kinetics/PLC_g/Ca_act_PLC_g* /kinetics/PLC_g/Ca.PLC_g* REAC B A
addmsg /kinetics/EGFR/L.EGFR/phosph_PLC_g /kinetics/PLC_g/Ca.PLC_g* MM_PRD pA
addmsg /kinetics/PLC_g/dephosph_PLC_g /kinetics/PLC_g/Ca.PLC_g* REAC A B
addmsg /kinetics/PLC_g/Ca.PLC_g* /kinetics/PLC_g/Ca.PLC_g*/PIP2_hydrolysis ENZYME n
addmsg /kinetics/PIP2 /kinetics/PLC_g/Ca.PLC_g*/PIP2_hydrolysis SUBSTRATE n
addmsg /kinetics/CaRegulation/CaTransp-2Ca /kinetics/CaRegulation/CaTraspATPase SUBSTRATE n
addmsg /kinetics/CaRegulation/CaTransp /kinetics/CaRegulation/CaTraspATPase PRODUCT n
addmsg /kinetics/CaRegulation/Ca-sequester /kinetics/CaRegulation/CaTraspATPase PRODUCT n
addmsg /kinetics/CaRegulation/Ca-sequester /kinetics/CaRegulation/CaTraspATPase PRODUCT n
addmsg /kinetics/CaRegulation/CaTraspATPase /kinetics/CaRegulation/Ca-sequester REAC B A
addmsg /kinetics/CaRegulation/IP3R*/IP3chan /kinetics/CaRegulation/Ca-sequester REAC A B
addmsg /kinetics/CaRegulation/Ca-leak-to-cytoplasm/Ca-leak-chan /kinetics/CaRegulation/Ca-sequester REAC A B
addmsg /kinetics/CaRegulation/CaTraspATPase /kinetics/CaRegulation/Ca-sequester REAC B A
addmsg /kinetics/CaRegulation/inactivate_cap_Ca /kinetics/CaRegulation/Ca-sequester REAC A B
addmsg /kinetics/CaRegulation/inactivate_cap_Ca /kinetics/CaRegulation/Ca-sequester REAC A B
addmsg /kinetics/CaRegulation/Ca-leak-to-cytoplasm /kinetics/CaRegulation/Ca-leak-to-cytoplasm/Ca-leak-chan NUMCHAN n
addmsg /kinetics/CaRegulation/Ca-sequester /kinetics/CaRegulation/Ca-leak-to-cytoplasm/Ca-leak-chan SUBSTRATE n vol
addmsg /kinetics/Ca /kinetics/CaRegulation/Ca-leak-to-cytoplasm/Ca-leak-chan PRODUCT n vol
addmsg /kinetics/CaRegulation/CaTraspATPase /kinetics/CaRegulation/CaTransp-2Ca REAC A B
addmsg /kinetics/CaRegulation/Ca-bind-to-Transp /kinetics/CaRegulation/CaTransp-2Ca REAC B A
addmsg /kinetics/CaRegulation/CaTransp /kinetics/CaRegulation/CaTransp-2Ca CONSERVE n nInit
addmsg /kinetics/CaRegulation/Ca-bind-to-Transp /kinetics/CaRegulation/CaTransp REAC A B
addmsg /kinetics/CaRegulation/CaTraspATPase /kinetics/CaRegulation/CaTransp REAC B A
addmsg /kinetics/Ca /kinetics/CaRegulation/Ca-bind-to-Transp SUBSTRATE n
addmsg /kinetics/CaRegulation/CaTransp /kinetics/CaRegulation/Ca-bind-to-Transp SUBSTRATE n
addmsg /kinetics/Ca /kinetics/CaRegulation/Ca-bind-to-Transp SUBSTRATE n
addmsg /kinetics/CaRegulation/CaTransp-2Ca /kinetics/CaRegulation/Ca-bind-to-Transp PRODUCT n
addmsg /kinetics/CaRegulation/IP3Rbind /kinetics/CaRegulation/IP3R REAC A B
addmsg /kinetics/CaRegulation/IP3R* /kinetics/CaRegulation/IP3Rbind PRODUCT n
addmsg /kinetics/CaRegulation/IP3R /kinetics/CaRegulation/IP3Rbind SUBSTRATE n
addmsg /kinetics/IP3 /kinetics/CaRegulation/IP3Rbind SUBSTRATE n
addmsg /kinetics/IP3 /kinetics/CaRegulation/IP3Rbind SUBSTRATE n
addmsg /kinetics/IP3 /kinetics/CaRegulation/IP3Rbind SUBSTRATE n
addmsg /kinetics/CaRegulation/IP3Rbind /kinetics/CaRegulation/IP3R* REAC B A
addmsg /kinetics/CaRegulation/IP3R* /kinetics/CaRegulation/IP3R*/IP3chan NUMCHAN n
addmsg /kinetics/CaRegulation/Ca-sequester /kinetics/CaRegulation/IP3R*/IP3chan SUBSTRATE n vol
addmsg /kinetics/Ca /kinetics/CaRegulation/IP3R*/IP3chan PRODUCT n vol
addmsg /kinetics/CaRegulation/CaEPump/Ca-pump-out /kinetics/CaRegulation/CaEPump REAC eA B
addmsg /kinetics/CaRegulation/CaEPump/Ca-pump-out /kinetics/CaRegulation/CaEPump CONSERVE nComplex nComplexInit
addmsg /kinetics/CaRegulation/CaEPump /kinetics/CaRegulation/CaEPump/Ca-pump-out ENZYME n
addmsg /kinetics/Ca /kinetics/CaRegulation/CaEPump/Ca-pump-out SUBSTRATE n
addmsg /kinetics/CaRegulation/Ca-leak-from-extracell/Ca-leak-chan /kinetics/CaRegulation/Ca-ext REAC A B
addmsg /kinetics/CaRegulation/CaEPump/Ca-pump-out /kinetics/CaRegulation/Ca-ext MM_PRD pA
addmsg /kinetics/CaRegulation/capacitive_Ca_entry*/Cap_entry_chan /kinetics/CaRegulation/Ca-ext REAC A B
addmsg /kinetics/CaRegulation/Ca-leak-from-extracell /kinetics/CaRegulation/Ca-leak-from-extracell/Ca-leak-chan NUMCHAN n
addmsg /kinetics/CaRegulation/Ca-ext /kinetics/CaRegulation/Ca-leak-from-extracell/Ca-leak-chan SUBSTRATE n vol
addmsg /kinetics/Ca /kinetics/CaRegulation/Ca-leak-from-extracell/Ca-leak-chan PRODUCT n vol
addmsg /kinetics/CaRegulation/inactivate_cap_Ca /kinetics/CaRegulation/capacitive_Ca_entry* REAC A B
addmsg /kinetics/CaRegulation/capacitive_Ca_entry* /kinetics/CaRegulation/capacitive_Ca_entry*/Cap_entry_chan NUMCHAN n
addmsg /kinetics/CaRegulation/Ca-ext /kinetics/CaRegulation/capacitive_Ca_entry*/Cap_entry_chan SUBSTRATE n vol
addmsg /kinetics/Ca /kinetics/CaRegulation/capacitive_Ca_entry*/Cap_entry_chan PRODUCT n vol
addmsg /kinetics/CaRegulation/Ca-sequester /kinetics/CaRegulation/inactivate_cap_Ca SUBSTRATE n
addmsg /kinetics/CaRegulation/Ca-sequester /kinetics/CaRegulation/inactivate_cap_Ca SUBSTRATE n
addmsg /kinetics/CaRegulation/capacitive_Ca_entry* /kinetics/CaRegulation/inactivate_cap_Ca SUBSTRATE n
addmsg /kinetics/CaRegulation/inact_cap_entry /kinetics/CaRegulation/inactivate_cap_Ca PRODUCT n
addmsg /kinetics/CaRegulation/inactivate_cap_Ca /kinetics/CaRegulation/inact_cap_entry REAC B A
addmsg /kinetics/MAPK* /graphs/conc1/MAPK*.Co PLOT Co *MAPK*.Co *orange
addmsg /kinetics/PKC-active /graphs/conc1/PKC-active.Co PLOT Co *PKC-active.Co *yellow
addmsg /kinetics/EGFR/EGF /graphs/conc2/EGF.Co PLOT Co *EGF.Co *red
addmsg /kinetics/EGFR/EGFR /graphs/conc2/EGFR.Co PLOT Co *EGFR.Co *red
addmsg /kinetics/PLC_g/Ca.PLC_g* /graphs/conc2/Ca.PLC_g*.Co PLOT Co *Ca.PLC_g*.Co *pink
addmsg /kinetics/PLC_g/Ca.PLC_g /graphs/conc2/Ca.PLC_g.Co PLOT Co *Ca.PLC_g.Co *pink
addmsg /kinetics/EGFR/SHC* /graphs/conc2/SHC*.Co PLOT Co *SHC*.Co *orange
addmsg /kinetics/Sos/Sos /moregraphs/conc3/Sos.Co PLOT Co *Sos.Co *red
addmsg /kinetics/Sos/Sos.Grb2 /moregraphs/conc3/Sos.Grb2.Co PLOT Co *Sos.Grb2.Co *orange
addmsg /kinetics/Shc*.Sos.Grb2 /moregraphs/conc3/Shc*.Sos.Grb2.Co PLOT Co *Shc*.Sos.Grb2.Co *brown
addmsg /kinetics/IP3 /moregraphs/conc4/IP3.Co PLOT Co *IP3.Co *pink
addmsg /kinetics/DAG /moregraphs/conc4/DAG.Co PLOT Co *DAG.Co *green
enddump
// End of dump
call /kinetics/doqcsinfo/notes LOAD \
"This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse.
Demonstration script files for generating the figures in the paper, including figure 2, are available here."
complete_loading