//  DOQCS : http://doqcs.ncbs.res.in/ 
//  Accession Name = fig4_synapse 
//  Accession Number = 3 
//  Transcriber = Upinder S. Bhalla, NCBS 
//  Developer = Upinder S. Bhalla, NCBS 
//  Species = Generic mammalian 
//  Tissue = Neuronal 
//  Cell Compartment = Synapse 
//  Notes =  This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From <a href="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9888852&dopt=Abstract">Bhalla US and Iyengar R. Science (1999) 283(5400):381-7</a>.This model comes from figure 4 of that paper.<br>Demonstration script files for generating the figures in the paper, including figure 4, are available <a href="http://www.ncbs.res.in/~bhalla/ltploop/ltploop/demos/">here</a>. 
 
 //genesis
// kkit Version 11 flat dumpfile
 
// Saved on Mon Aug  7 16:05:51 2006
 
include kkit {argv 1}
 
FASTDT = 0.0005
SIMDT = 0.0005
CONTROLDT = 1
PLOTDT = 0.001
MAXTIME = 2
TRANSIENT_TIME = 2
VARIABLE_DT_FLAG = 0
DEFAULT_VOL = 1.6667e-21
VERSION = 11.0
setfield /file/modpath value /home2/bhalla/scripts/modules
kparms
 
//genesis

initdump -version 3 -ignoreorphans 1
simobjdump doqcsinfo filename accessname accesstype transcriber developer \
  citation species tissue cellcompartment methodology sources \
  model_implementation model_validation x y z
simobjdump table input output alloced step_mode stepsize x y z
simobjdump xtree path script namemode sizescale
simobjdump xcoredraw xmin xmax ymin ymax
simobjdump xtext editable
simobjdump xgraph xmin xmax ymin ymax overlay
simobjdump xplot pixflags script fg ysquish do_slope wy
simobjdump group xtree_fg_req xtree_textfg_req plotfield expanded movealone \
  link savename file version md5sum mod_save_flag x y z
simobjdump geometry size dim shape outside xtree_fg_req xtree_textfg_req x y \
  z
simobjdump kpool DiffConst CoInit Co n nInit mwt nMin vol slave_enable \
  geomname xtree_fg_req xtree_textfg_req x y z
simobjdump kreac kf kb notes xtree_fg_req xtree_textfg_req x y z
simobjdump kenz CoComplexInit CoComplex nComplexInit nComplex vol k1 k2 k3 \
  keepconc usecomplex notes xtree_fg_req xtree_textfg_req link x y z
simobjdump stim level1 width1 delay1 level2 width2 delay2 baselevel trig_time \
  trig_mode notes xtree_fg_req xtree_textfg_req is_running x y z
simobjdump xtab input output alloced step_mode stepsize notes editfunc \
  xtree_fg_req xtree_textfg_req baselevel last_x last_y is_running x y z
simobjdump kchan perm gmax Vm is_active use_nernst notes xtree_fg_req \
  xtree_textfg_req x y z
simobjdump transport input output alloced step_mode stepsize dt delay clock \
  kf xtree_fg_req xtree_textfg_req x y z
simobjdump proto x y z
simundump geometry /kinetics/geometry 0 1e-15 3 sphere "" white black 35 19 0
simundump geometry /kinetics/geometry[1] 0 1.6667e-21 3 sphere "" white black \
  0 0 0
simundump group /kinetics/PKC 0 blue black x 0 0 "" defaultfile defaultfile.g \
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simundump kpool /kinetics/PKC/PKC-Ca 0 0 3.7208e-17 3.7208e-17 2.2325e-11 \
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simundump kreac /kinetics/PKC/PKC-act-by-Ca 0 1e-06 0.5 "" white blue -4.0752 \
  -0.12295 0
simundump kreac /kinetics/PKC/PKC-act-by-DAG 0 1.3333e-08 8.6348 "" white \
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simundump kreac /kinetics/PKC/PKC-Ca-to-memb 0 1.2705 3.5026 "" white blue \
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simundump kreac /kinetics/PKC/PKC-DAG-to-memb 0 1 0.1 "" white blue -2.6168 \
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simundump kreac /kinetics/PKC/PKC-act-by-Ca-AA 0 2e-09 0.1 "" white blue \
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simundump kreac /kinetics/PKC/PKC-act-by-DAG-AA 0 2 0.2 "" white blue 1.2492 \
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simundump kpool /kinetics/PKC/PKC-DAG-AA* 0 0 4.9137e-18 4.9137e-18 \
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simundump kpool /kinetics/PKC/PKC-Ca-AA* 0 0 1.75e-16 1.75e-16 1.05e-10 \
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simundump kpool /kinetics/PKC/PKC-Ca-memb* 0 0 1.3896e-17 1.3896e-17 \
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simundump kpool /kinetics/PKC/PKC-DAG-memb* 0 0 9.4352e-21 9.4352e-21 \
  5.6611e-15 5.6611e-15 0 0 6e+05 0 /kinetics/geometry yellow blue -1.8297 \
  5.5078 0
simundump kpool /kinetics/PKC/PKC-basal* 0 0 0.02 0.02 12000 12000 0 0 6e+05 \
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simundump kreac /kinetics/PKC/PKC-basal-act 0 1 50 "" white blue -4.978 \
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simundump kpool /kinetics/PKC/PKC-AA* 0 0 1.8133e-17 1.8133e-17 1.088e-11 \
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simundump kreac /kinetics/PKC/PKC-act-by-AA 0 2e-10 0.1 "" white blue -4.9925 \
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simundump kpool /kinetics/PKC/PKC-Ca-DAG 0 0 8.4632e-23 8.4632e-23 5.0779e-17 \
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simundump kreac /kinetics/PKC/PKC-n-DAG 0 1e-09 0.1 "" white blue -3.0103 \
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simundump kpool /kinetics/PKC/PKC-DAG 0 0 1.161e-16 1.161e-16 6.9661e-11 \
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simundump kreac /kinetics/PKC/PKC-n-DAG-AA 0 3e-08 2 "" white blue -1.2278 \
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simundump kpool /kinetics/PKC/PKC-DAG-AA 0 0 2.5188e-19 2.5188e-19 1.5113e-13 \
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simundump kpool /kinetics/PKC/PKC-cytosolic 0 0 1 1 6e+05 6e+05 0 0 6e+05 0 \
  /kinetics/geometry white blue -6.1315 0.59711 0
simundump kpool /kinetics/DAG 1 0 0 0 0 0 0 0 6e+05 2 /kinetics/geometry \
  green black -3.2051 -4.7168 0
simundump kpool /kinetics/Ca 1 0 0.08 0.08 48000 48000 0 0 6e+05 2 \
  /kinetics/geometry red black -19.3 10.35 0
simundump kpool /kinetics/AA 0 0 0 0 0 0 0 0 6e+05 0 /kinetics/geometry \
  darkgreen black -3.2898 -9.3376 0
simundump kpool /kinetics/PKC-active 1 0 2.1222e-16 0.02 12000 12000 0 0 \
  6e+05 2 /kinetics/geometry red black 2.1325 8.477 0
simundump kenz /kinetics/PKC-active/PKC-act-raf 1 0 0 0 0 6e+05 5e-07 16 4 0 \
  0 "" red yellow "" 6.2532 10.549 0
simundump kenz /kinetics/PKC-active/PKC-inact-GAP 1 0 0 0 0 1 1e-05 16 4 0 0 \
  "" red yellow "" 3.4391 11.804 0
simundump kenz /kinetics/PKC-active/PKC-act-GEF 1 0 0 0 0 1 1e-05 16 4 0 0 "" \
  red yellow "" -0.24791 17.264 0
simundump kenz /kinetics/PKC-active/PKC-phosph-neurogranin 1 0 0 0 0 6e+05 \
  1.7e-07 2.34 0.58 0 0 "" red red "" -49.005 -4.4126 0
simundump kenz /kinetics/PKC-active/PKC-phosph-ng-CaM 1 0 0 0 0 6e+05 \
  1.02e-07 1.4 0.35 0 0 "" red red "" -52.441 -1.6274 0
simundump kenz /kinetics/PKC-active/phosph-AC2 1 0 0 0 0 6e+05 1e-06 16 4 0 0 \
  "" red red "" -16.815 -21.28 0
simundump group /kinetics/PLA2 0 darkgreen black x 0 1 "" defaultfile \
  defaultfile.g 0 0 0 -7.3572 -14.209 0
simundump kpool /kinetics/PLA2/PLA2-cytosolic 0 0 0.4 0.4 2.4e+05 2.4e+05 0 0 \
  6e+05 0 /kinetics/geometry yellow darkgreen -11.824 -8.9421 0
simundump kreac /kinetics/PLA2/PLA2-Ca-act 0 1.6667e-06 0.1 "" white \
  darkgreen -11.097 -11.104 0
simundump kpool /kinetics/PLA2/PLA2-Ca* 0 0 0 0 0 0 0 0 6e+05 0 \
  /kinetics/geometry yellow darkgreen -8.722 -11.646 0
simundump kenz /kinetics/PLA2/PLA2-Ca*/kenz 0 0 0 0 0 6e+05 2.25e-06 21.6 5.4 \
  0 0 "" red yellow "" -6.0553 -11.667 0
simundump kreac /kinetics/PLA2/PIP2-PLA2-act 0 2e-09 0.5 "" white darkgreen \
  -11.055 -6.7502 0
simundump kpool /kinetics/PLA2/PIP2-PLA2* 0 0 0 0 0 0 0 0 6e+05 0 \
  /kinetics/geometry cyan darkgreen -8.6803 -6.2919 0
simundump kenz /kinetics/PLA2/PIP2-PLA2*/kenz 0 0 0 0 0 6e+05 4.6e-06 44.16 \
  11.04 0 0 "" red cyan "" -6.0345 -6.271 0
simundump kreac /kinetics/PLA2/PIP2-Ca-PLA2-act 0 2e-08 0.1 "" white \
  darkgreen -10.097 -7.5002 0
simundump kpool /kinetics/PLA2/PIP2-Ca-PLA2* 0 0 0 0 0 0 0 0 6e+05 0 \
  /kinetics/geometry cyan darkgreen -8.3261 -7.896 0
simundump kenz /kinetics/PLA2/PIP2-Ca-PLA2*/kenz 0 0 0 0 0 6e+05 1.5e-05 144 \
  36 0 0 "" red cyan "" -5.972 -7.9794 0
simundump kreac /kinetics/PLA2/DAG-Ca-PLA2-act 0 5e-09 4 "" white darkgreen \
  -10.826 -9.8336 0
simundump kpool /kinetics/PLA2/DAG-Ca-PLA2* 0 0 0 0 0 0 0 0 6e+05 0 \
  /kinetics/geometry pink darkgreen -8.1386 -10.479 0
simundump kenz /kinetics/PLA2/DAG-Ca-PLA2*/kenz 0 0 0 0 0 6e+05 2.5e-05 240 \
  60 0 0 "" red pink "" -5.9511 -10.354 0
simundump kpool /kinetics/PLA2/APC 0 0 30 30 1.8e+07 1.8e+07 0 0 6e+05 5 \
  /kinetics/geometry yellow darkgreen -8.2386 -9.9634 0
simundump kreac /kinetics/PLA2/Degrade-AA 1 0.4 0 "" white darkgreen -6.1808 \
  -5.2875 0
simundump kpool /kinetics/PLA2/PLA2*-Ca 0 0 0 0 0 0 0 0 6e+05 1 \
  /kinetics/geometry orange darkgreen -7.813 -12.687 0
simundump kenz /kinetics/PLA2/PLA2*-Ca/kenz 0 0 0 0 0 6e+05 5e-05 480 120 0 0 \
  "" red orange "" -6.0814 -12.817 0
simundump kpool /kinetics/PLA2/PLA2* 1 0 0 0 0 0 0 0 6e+05 0 \
  /kinetics/geometry orange darkgreen -9.025 -14.851 0
simundump kreac /kinetics/PLA2/PLA2*-Ca-act 1 1e-05 0.1 "" white darkgreen \
  -10.086 -12.752 0
simundump kreac /kinetics/PLA2/dephosphorylate-PLA2* 1 0.17 0 "" white \
  darkgreen -13.693 -11.735 0
simundump kpool /kinetics/MAPK* 0 0 0 0 0 0 0 0 6e+05 0 /kinetics/geometry \
  orange yellow 12.492 0.77602 0
simundump kenz /kinetics/MAPK*/MAPK* 0 0 0 0 0 6e+05 6.5e-06 80 20 0 0 "" red \
  orange "" -12.005 -14.94 0
simundump kenz /kinetics/MAPK*/MAPK*-feedback 1 0 0 0 0 6e+05 3.25e-06 40 10 \
  0 0 "" red orange "" 10.387 10.668 0
simundump kpool /kinetics/temp-PIP2 1 0 2.5 2.5 1.5e+06 1.5e+06 0 0 6e+05 6 \
  /kinetics/geometry green black -15.796 -7.0473 0
simundump kpool /kinetics/IP3 1 0 0 0 0 0 0 0 6e+05 0 /kinetics/geometry pink \
  black -0.77375 -4.6555 0
simundump kpool /kinetics/Glu 1 0 0 0 0 0 0 0 6e+05 0 /kinetics/geometry \
  green black -0.79501 13.884 0
simundump group /kinetics/PLCbeta 1 maroon black x 0 0 "" defaultfile \
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simundump kreac /kinetics/PLCbeta/Act-PLC-Ca 1 5e-06 1 "" white maroon 3.0709 \
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simundump kpool /kinetics/PLCbeta/PLC 1 0 0.8 0.8 4.8e+05 4.8e+05 0 0 6e+05 0 \
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simundump kreac /kinetics/PLCbeta/Degrade-IP3 1 1 0 "" white maroon 2.3125 \
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simundump kpool /kinetics/PLCbeta/Inositol 1 0 0 0 0 0 0 0 6e+05 5 \
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simundump kreac /kinetics/PLCbeta/Degrade-DAG 1 0.02 0 "" white maroon \
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simundump kpool /kinetics/PLCbeta/PC 1 0 0 0 0 0 0 0 1 4 \
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simundump kpool /kinetics/PLCbeta/PLC-Ca 1 0 0 0 0 0 0 0 6e+05 0 \
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simundump kenz /kinetics/PLCbeta/PLC-Ca/PLC-Ca 1 0 0 0 0 6e+05 4.2e-06 40 10 \
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simundump kreac /kinetics/PLCbeta/Act-PLC-by-Gq 1 4.2e-05 1 "" white maroon \
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simundump kreac /kinetics/PLCbeta/Inact-PLC-Gq 1 0.0133 0 "" white maroon \
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simundump kpool /kinetics/PLCbeta/PLC-Ca-Gq 0 0 0 0 0 0 0 0 6e+05 0 \
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simundump kenz /kinetics/PLCbeta/PLC-Ca-Gq/PLCb-Ca-Gq 0 0 0 0 0 6e+05 8e-05 \
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simundump kpool /kinetics/PLCbeta/PLC-Gq 1 0 0 0 0 0 0 0 6e+05 0 \
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simundump kreac /kinetics/PLCbeta/PLC-bind-Gq 1 4.2e-06 1 "" white maroon \
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simundump kreac /kinetics/PLCbeta/PLC-Gq-bind-Ca 1 5e-05 1 "" white maroon \
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simundump kpool /kinetics/PIP2 1 0 2.5 2.5 1.5e+06 1.5e+06 0 0 6e+05 6 \
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simundump kpool /kinetics/BetaGamma 1 0 0 0 0 0 0 0 6e+05 0 \
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simundump kpool /kinetics/G*GTP 1 0 0 0 0 0 0 0 6e+05 2 /kinetics/geometry \
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simundump kpool /kinetics/G*GDP 1 0 0 0 0 0 0 0 6e+05 0 /kinetics/geometry \
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simundump group /kinetics/Gq 1 blue black x 0 0 "" defaultfile defaultfile.g \
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simundump kreac /kinetics/Gq/RecLigandBinding 1 2.8e-05 10 "" white blue \
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simundump kpool /kinetics/Gq/G-GDP 1 0 1 1 6e+05 6e+05 0 0 6e+05 0 \
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simundump kreac /kinetics/Gq/Basal-Act-G 1 1e-04 0 "" white blue 9.805 \
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simundump kreac /kinetics/Gq/Trimerize-G 1 1e-05 0 "" white blue 12.255 \
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simundump kreac /kinetics/Gq/Inact-G 1 0.0133 0 "" white blue 10.218 -7.6095 \
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simundump kpool /kinetics/Gq/mGluR 1 0 0.3 0.3 1.8e+05 1.8e+05 0 0 6e+05 0 \
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simundump kpool /kinetics/Gq/Rec-Glu 1 0 0 0 0 0 0 0 6e+05 0 \
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simundump kpool /kinetics/Gq/Rec-Gq 1 0 0 0 0 0 0 0 6e+05 0 \
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simundump kreac /kinetics/Gq/Rec-Glu-bind-Gq 1 1e-08 1e-04 "" white blue \
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simundump kreac /kinetics/Gq/Glu-bind-Rec-Gq 1 2.8e-05 0.1 "" white blue \
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simundump kreac /kinetics/Gq/Activate-Gq 1 0.01 0 "" white blue 7.0172 \
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simundump kpool /kinetics/Gq/Blocked-rec-Gq 1 0 0 0 0 0 0 0 6e+05 0 \
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simundump group /kinetics/MAPK 0 brown black x 0 0 "" defaultfile \
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simundump kpool /kinetics/MAPK/craf-1 0 0 0.2 0.2 1.2e+05 1.2e+05 0 0 6e+05 0 \
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simundump kpool /kinetics/MAPK/craf-1* 0 0 0 0 0 0 0 0 6e+05 0 \
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simundump kpool /kinetics/MAPK/MAPKK 0 0 0.18 0.18 1.08e+05 1.08e+05 0 0 \
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simundump kpool /kinetics/MAPK/MAPK 0 0 0.36 0.36 2.16e+05 2.16e+05 0 0 6e+05 \
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simundump kpool /kinetics/MAPK/craf-1** 1 0 0 0 0 0 0 0 6e+05 0 \
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simundump kpool /kinetics/MAPK/MAPK-tyr 1 0 0 0 0 0 0 0 6e+05 0 \
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simundump kpool /kinetics/MAPK/MAPKK* 0 0 0 0 0 0 0 0 6e+05 0 \
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simundump kenz /kinetics/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 6e+05 2.7e-05 0.6 \
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simundump kpool /kinetics/MAPK/Raf-GTP-Ras* 1 0 0 0 0 0 0 0 6e+05 0 \
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simundump kenz /kinetics/MKP-1/MKP1-tyr-deph 1 0 0 0 0 6e+05 0.000125 4 1 0 0 \
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simundump kenz /kinetics/MKP-1/MKP1-thr-deph 1 0 0 0 0 6e+05 0.000125 4 1 0 0 \
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simundump kreac /kinetics/Ras-act-craf 1 4e-05 0.5 "" white black 3.5614 \
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simundump kenz /kinetics/PPhosphatase2A/MAPKK-deph 1 0 0 0 0 6e+05 3.3e-06 25 \
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simundump kenz /kinetics/PPhosphatase2A/MAPKK-deph-ser 1 0 0 0 0 6e+05 \
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simundump kenz /kinetics/PPhosphatase2A/craf**-deph 1 0 0 0 0 1 3.3e-06 25 6 \
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simundump group /kinetics/Ras 1 blue black x 0 0 "" defaultfile defaultfile.g \
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simundump kpool /kinetics/Ras/GEF-Gprot-bg 1 0 0 0 0 0 0 0 6e+05 0 \
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simundump kpool /kinetics/Ras/GEF* 1 0 0 0 0 0 0 0 6e+05 0 /kinetics/geometry \
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simundump kenz /kinetics/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 6e+05 3.3e-07 0.08 \
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simundump kpool /kinetics/Ras/GTP-Ras 1 0 0 0 0 0 0 0 6e+05 0 \
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simundump kpool /kinetics/Ras/GDP-Ras 1 0 0.2 0.2 1.2e+05 1.2e+05 0 0 6e+05 0 \
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  "General Mammalian" Neuronal Synapse \
  "Quantitative match to experiments, Qualitative, Hypothetical" \
  "<a href=http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9888852&dopt=Abstract>Bhalla US and Iyengar R. Science (1999) 283(5400):381-7</a>( Peer-reviewed publication)" \
  "Exact GENESIS implementation" \
  "Approximates original data , Quantitatively predicts new data" 35 22 0
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simundump xtext /file/notes 0 1
xtextload /file/notes \
"all125 plus plots plus stims." \
"Eliminated notes for portability."
addmsg /kinetics/PKC/PKC-act-by-Ca /kinetics/PKC/PKC-Ca REAC B A 
addmsg /kinetics/PKC/PKC-act-by-DAG /kinetics/PKC/PKC-Ca REAC A B 
addmsg /kinetics/PKC/PKC-Ca-to-memb /kinetics/PKC/PKC-Ca REAC A B 
addmsg /kinetics/PKC/PKC-act-by-Ca-AA /kinetics/PKC/PKC-Ca REAC A B 
addmsg /kinetics/PKC/PKC-cytosolic /kinetics/PKC/PKC-act-by-Ca SUBSTRATE n 
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addmsg /kinetics/CaM(Ca)n-CaNAB/dephosph-PP1-I* /kinetics/PP1/PP1-I1 MM_PRD pA 
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addmsg /kinetics/PP2B/CaMCa4-bind-CaNAB /kinetics/PP2B/CaMCa4-CaNAB REAC B A 
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addmsg /kinetics/PKA/Release-C1 /kinetics/PKA/R2C2-cAMP4 REAC A B 
addmsg /kinetics/PKA/Release-C1 /kinetics/PKA/R2C-cAMP4 REAC B A 
addmsg /kinetics/PKA/Release-C2 /kinetics/PKA/R2C-cAMP4 REAC A B 
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addmsg /kinetics/Glu /kinetics/remove_glu SUBSTRATE n 
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addmsg /kinetics/remove_glu /kinetics/synapse REAC B A 
addmsg /kinetics/stim /kinetics/synapse SLAVE output 
addmsg /kinetics/CaMKII/tot_CaM_CaMKII /kinetics/CaMKII-act SUMTOTAL n nInit 
addmsg /kinetics/CaMKII/tot_autonomous_CaMKII /kinetics/CaMKII-act SUMTOTAL n nInit 
addmsg /kinetics/CaM(Ca)n-CaNAB /kinetics/CaN-active SUMTOTAL n nInit 
addmsg /kinetics/CaNAB-Ca4 /kinetics/CaN-active SUMTOTAL n nInit 
addmsg /kinetics/PP1-active /kinetics/tot_PP1-act SUMTOTAL n nInit 
addmsg /kinetics/PP1-active/Deph-thr286 /kinetics/tot_PP1-act SUMTOTAL nComplex nComplexInit 
addmsg /kinetics/PP1-active/Deph-thr305 /kinetics/tot_PP1-act SUMTOTAL nComplex nComplexInit 
addmsg /kinetics/PP1-active/Deph-thr286c /kinetics/tot_PP1-act SUMTOTAL nComplex nComplexInit 
addmsg /kinetics/PP1-active/Deph_thr286b /kinetics/tot_PP1-act SUMTOTAL nComplex nComplexInit 
addmsg /kinetics/PP1-active/Deph-thr306 /kinetics/tot_PP1-act SUMTOTAL nComplex nComplexInit 
addmsg /kinetics/PKC-active /graphs/conc1/PKC-active.Co PLOT Co *PKC-active.Co *red 
addmsg /kinetics/MAPK* /graphs/conc1/MAPK*.Co PLOT Co *MAPK*.Co *orange 
addmsg /kinetics/PKA-active /graphs/conc2/PKA-active.Co PLOT Co *PKA-active.Co *yellow 
addmsg /kinetics/CaMKII-act /moregraphs/conc3/CaMKII-act.Co PLOT Co *CaMKII-act.Co *blue 
addmsg /kinetics/Ca /moregraphs/conc3/Ca.Co PLOT Co *Ca.Co *red 
addmsg /kinetics/CaN-active /moregraphs/conc4/CaN-active.Co PLOT Co *CaN-active.Co *blue 
addmsg /kinetics/tot_PP1-act /moregraphs/conc4/tot_PP1-act.Co PLOT Co *tot_PP1-act.Co *red 
enddump
// End of dump

setfield /kinetics/Ca_tab table->dx 1
setfield /kinetics/Ca_tab table->invdx 1
call /kinetics/tot_PP1-act/notes LOAD \
" tot_PP1 has inputs from Deph-thr286, PP1-active, Deph-thr305, Deph-thr286c, Deph-thr286b,Deph-thr305. except PP1-active all other inputs are enzyme-substrate complex which is not currently supported by doqcs." \
"But can be accessed from GENESIS file."
call /kinetics/doqcsinfo/notes LOAD \
"This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From <a href =http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9888852&dopt=Abstract>Bhalla US and Iyengar R. Science (1999) 283(5400):381-7</a>.This model comes from figure 4 of that paper." \
"Demonstration script files for generating the figures in the paper, including figure 4, are available <a href=http://www.ncbs.res.in/~bhalla/ltploop/ltploop/demos/>here</a>."
complete_loading