//genesis // kkit Version 6 dumpfile // Saved on Thu May 7 00:11:17 1998 include kkit {argv 1} FASTDT = 0.001 SIMDT = 0.001 CONTROLDT = 1 PLOTDT = 1 MAXTIME = 300 kparms //genesis initdump -version 3 -ignoreorphans 1 simobjdump table input output alloced step_mode stepsize simobjdump xtree path script namemode sizescale simobjdump xcoredraw xmin xmax ymin ymax simobjdump xtext editable simobjdump xgraph xmin xmax ymin ymax overlay simobjdump xplot pixflags script fg ysquish do_slope wy simobjdump kpool CoTotal CoInit Co CoRemaining n nInit nTotal nMin vol \ slave_enable keepconc notes xtree_fg_req xtree_textfg_req simobjdump xtab input output alloced step_mode stepsize notes editfunc \ xtree_fg_req xtree_textfg_req plotfield manageclass baselevel last_x last_y \ is_running simobjdump group notes editfunc xtree_fg_req xtree_textfg_req plotfield \ manageclass expanded movealone simobjdump kreac A B kf kb is_active oldmsgmode notes editfunc xtree_fg_req \ xtree_textfg_req plotfield manageclass simobjdump kenz CoComplexInit CoComplex nComplexInit nComplex vol sA pA eA B \ k1 k2 k3 keepconc usecomplex ksum oldmsgmode notes editfunc xtree_fg_req \ xtree_textfg_req plotfield manageclass link_to_manage simundump group /kinetics/CaMKII 1 "" edit_group purple black x group 0 0 simundump kpool /kinetics/CaMKII/CaMKII 1 135 70 70 1.8098e-10 4.2e+07 \ 4.2e+07 8.1e+07 0 6e+05 0 0 "" palegreen purple simundump kpool /kinetics/CaMKII/CaMKII-CaM 1 0 0 0 0 0 0 0 0 6e+05 0 0 "" \ palegreen purple simundump kpool /kinetics/CaMKII/CaMKII-thr286*-CaM 1 1.6667e-06 0 0 \ 4.6297e-18 0 0 1 0 6e+05 0 0 "" palegreen purple simundump kpool /kinetics/CaMKII/CaMKII*** 1 1.6667e-06 0 0 0 0 0 1 0 6e+05 0 \ 0 "" cyan purple simundump kreac /kinetics/CaMKII/CaMKII-bind-CaM 1 0.00065017 0.00064747 \ 8.3333e-05 5 1 0 "" edit_reac white purple A group simundump kreac /kinetics/CaMKII/CaMK-thr286-bind-CaM 1 8.7227e-07 2.4765e-05 \ 0.001667 0.1 1 0 "" edit_reac white purple A group simundump kpool /kinetics/CaMKII/CaMKII-thr286 1 1.6667e-06 0 0 0 0 0 1 0 \ 6e+05 0 0 "" red purple simundump kpool /kinetics/CaMKII/CaMK-thr306 1 1.6667e-06 0 0 3.002e-18 0 0 1 \ 0 6e+05 0 0 "" palegreen purple simundump kpool /kinetics/CaMKII/total-CaMKII 1 70 70 70 0 4.2e+07 4.2e+07 \ 4.2e+07 0 6e+05 4 0 "" cyan purple simundump kreac /kinetics/CaMKII/basal-activity 1 0 1.2572e+05 0.003 0 1 0 "" \ edit_reac white purple A group simundump kpool /kinetics/CaMKII/tot_CaM_CaMKII 1 0 0 0 0 0 0 0 0 6e+05 0 0 \ "" green purple simundump kenz /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_305 1 0 0 0 0 6e+05 \ 3.7431e-06 9.3578e-07 4.6789e-06 4.8921e-06 18.48 24 6 0 0 30 0 "" edit_enz \ red green CoComplex kpool enzproto_to_pool_link simundump kenz /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_286 1 0 0 0 0 6e+05 \ 4.0051e-16 1.0013e-16 5.0063e-16 6.6157e-16 1.54 2 0.5 0 0 2.5 0 "" \ edit_enz red green CoComplex kpool enzproto_to_pool_link simundump kpool /kinetics/CaMKII/tot_autonomous_CaMKII 1 0 0 0 0 0 0 0 0 \ 6e+05 0 0 "" green purple simundump kenz /kinetics/CaMKII/tot_autonomous_CaMKII/auton_305 1 0 0 0 0 \ 6e+05 1357.1 339.27 1696.3 1836.1 12 24 6 0 0 30 0 "" edit_enz red green \ CoComplex kpool enzproto_to_pool_link simundump kenz /kinetics/CaMKII/tot_autonomous_CaMKII/auton_286 1 0 0 0 0 \ 6e+05 1.1107e-07 2.7769e-08 1.3884e-07 2.4831e-07 1 2 0.5 0 0 2.5 0 "" \ edit_enz red green CoComplex kpool enzproto_to_pool_link simundump kpool /kinetics/CaM-Ca4 1 5 0 0 1.3889e-11 0 0 3e+06 0 6e+05 0 0 "" \ blue yellow simundump kpool /kinetics/PP1-active 1 1.8 1.8 1.8 6.2578e-14 1.08e+06 \ 1.08e+06 1.08e+06 0 6e+05 0 0 "" cyan yellow simundump kenz /kinetics/PP1-active/Deph-thr286 1 0 0 0 0 6e+05 1.4954e-06 \ 3.7385e-07 1.8692e-06 5.3211e-06 5.72e-07 1.4 0.35 0 0 1.75 0 "" edit_enz \ red cyan CoComplex kpool enzproto_to_pool_link simundump kenz /kinetics/PP1-active/Deph-thr305 1 0 0 0 0 6e+05 9.462 2.3655 \ 11.828 44.338 5.72e-07 1.4 0.35 0 0 1.75 0 "" edit_enz red cyan CoComplex \ kpool enzproto_to_pool_link simundump kenz /kinetics/PP1-active/Deph-thr306 1 0 0 0 0 6e+05 0.032779 \ 0.0081946 0.040973 0.21448 5.72e-07 1.4 0.35 0 0 1.75 0 "" edit_enz red \ cyan CoComplex kpool enzproto_to_pool_link simundump kenz /kinetics/PP1-active/Deph-thr286c 1 0 0 0 0 6e+05 9.462 2.3655 \ 11.828 44.338 5.72e-07 1.4 0.35 0 0 1.75 0 "" edit_enz red cyan CoComplex \ kpool enzproto_to_pool_link simundump kenz /kinetics/PP1-active/Deph_thr286b 1 0 0 0 0 6e+05 18060 4515 \ 22575 48881 5.72e-07 1.4 0.35 0 0 1.75 0 "" edit_enz red cyan CoComplex \ kpool enzproto_to_pool_link simundump group /kinetics/CaM 1 "" edit_group blue black x group 0 0 simundump kpool /kinetics/CaM/CaM 1 25 20 20 3.5383e-11 1.2e+07 1.2e+07 \ 1.5e+07 0 6e+05 0 0 "" pink blue simundump kreac /kinetics/CaM/CaM-TR2-bind-Ca 1 2199.7 2198.2 2e-10 72 1 0 "" \ edit_reac white blue A group simundump kreac /kinetics/CaM/CaM-TR2-Ca2-bind-Ca 1 0.23432 0.22405 6e-06 10 \ 1 0 "" edit_reac white blue A group simundump kreac /kinetics/CaM/CaM-Ca3-bind-Ca 1 1.854e-06 2.2196e-05 7.75e-07 \ 10 1 0 "" edit_reac white blue A group simundump kpool /kinetics/CaM/neurogranin-CaM 1 1.6667e-06 0 0 0 0 0 1 0 \ 6e+05 0 0 "" red blue simundump kreac /kinetics/CaM/neurogranin-bind-CaM 1 4.6335e+06 4.9638e+06 \ 5e-07 1 1 0 "" edit_reac white blue A group simundump kpool /kinetics/CaM/neurogranin* 1 1.6667e-06 0 0 0 0 0 1 0 6e+05 0 \ 0 "" red blue simundump kpool /kinetics/CaM/neurogranin 1 10 10 10 2.1532e-11 6e+06 6e+06 \ 6e+06 0 6e+05 0 0 "" red blue simundump kreac /kinetics/CaM/dephosph-neurogranin 1 0 16.6 0.005 0 1 0 "" \ edit_reac white blue A group simundump kpool /kinetics/Ca 1 0.16 0.08 0.08 4.3878e-13 48000 48000 96000 0 \ 6e+05 2 0 "" red black simundump kpool /kinetics/PKC-active 1 1.5 0.09 0.09 6.4325e-40 54000 54000 \ 9e+05 0 6e+05 4 0 "" red black simundump kenz /kinetics/PKC-active/PKC-phosph-neurogranin 1 0 0 0 0 6e+05 \ 11546 2861.7 14407 12387 1.7e-07 2.34 0.58 0 0 2.92 0 "" edit_enz red red \ CoComplex kpool enzproto_to_pool_link simundump kenz /kinetics/PKC-active/PKC-phosph-ng-CaM 1 0 0 0 0 6e+05 13072 \ 3268 16340 25521 1.02e-07 1.4 0.35 0 0 1.75 0 "" edit_enz red red CoComplex \ kpool enzproto_to_pool_link simundump kenz /kinetics/PKC-active/phosph-AC2 1 0 0 0 0 6e+05 385.13 96.283 \ 481.41 481.17 1e-06 16 4 0 0 20 0 "" edit_enz red red CoComplex kpool \ enzproto_to_pool_link simundump kpool /kinetics/CaM-Ca3 1 1.6667e-06 0 0 4.5212e-18 0 0 1 0 6e+05 0 \ 0 "" hotpink yellow simundump kpool /kinetics/CaM-TR2-Ca2 1 1.6667e-06 0 0 0 0 0 1 0 6e+05 0 0 "" \ pink yellow simundump kpool /kinetics/CaM(Ca)n-CaNAB 1 0 0 0 0 0 0 0 0 6e+05 0 1 "" \ darkblue yellow simundump kenz /kinetics/CaM(Ca)n-CaNAB/dephosph_neurogranin 1 0 0 0 0 6e+05 \ 2.3684e-09 5.9431e-10 2.9627e-09 5.356e-09 5.56e-07 2.67 0.67 0 0 3.34 0 "" \ edit_enz red darkblue CoComplex kpool enzproto_to_pool_link simundump kenz /kinetics/CaM(Ca)n-CaNAB/dephosph_inhib1 1 0 0 0 0 6e+05 \ 6.4868e-14 1.6217e-14 8.1085e-14 1.0534e-13 5.7e-07 1.36 0.34 0 0 1.7 0 "" \ edit_enz red darkblue CoComplex kpool enzproto_to_pool_link simundump kenz /kinetics/CaM(Ca)n-CaNAB/dephosph-PP1-I* 1 0 0 0 0 6e+05 \ 5.2822e-10 1.3206e-10 6.6028e-10 9.3617e-10 5.7e-07 1.36 0.34 0 0 1.7 0 "" \ edit_enz white darkblue CoComplex kpool enzproto_to_pool_link simundump group /kinetics/PP1 1 "" edit_group yellow black x group 0 0 simundump kpool /kinetics/PP1/I1 1 1.8 1.8 1.8 0 1.08e+06 1.08e+06 1.08e+06 0 \ 6e+05 0 1 "" orange yellow simundump kpool /kinetics/PP1/I1* 1 0.1 0.001 0.001 2.7778e-13 600 600 60000 \ 0 6e+05 0 0 "" orange yellow simundump kreac /kinetics/PP1/Inact-PP1 1 56.605 56.604 0.0008333 0.1 1 0 "" \ edit_reac white yellow A group simundump kpool /kinetics/PP1/PP1-I1* 1 1.6667e-06 0 0 0 0 0 1 0 6e+05 0 0 "" \ brown yellow simundump kpool /kinetics/PP1/PP1-I1 1 1.6667e-06 0 0 0 0 0 1 0 6e+05 0 0 "" \ brown yellow simundump kreac /kinetics/PP1/dissoc-PP1-I1 1 0 27.499 1 0 1 0 "" edit_reac \ white yellow A group simundump kpool /kinetics/PKA-active 1 1.6667e-06 0 0 4.6297e-18 0 0 1 0 \ 6e+05 0 0 "" yellow black simundump kenz /kinetics/PKA-active/PKA-phosph-I1 1 0 0 0 0 6e+05 3.1565e-09 \ 7.8913e-10 3.9457e-09 5.0577e-09 1e-05 36 9 0 0 45 0 "" edit_enz red yellow \ CoComplex kpool enzproto_to_pool_link simundump kenz /kinetics/PKA-active/PKA-phosph-GAP 1 0 0 0 0 6e+05 3.0861e-14 \ 7.7153e-15 3.8576e-14 4.2147e-14 9e-05 108 27 0 0 135 0 "" edit_enz red \ yellow CoComplex kpool enzproto_to_pool_link simundump kenz /kinetics/PKA-active/phosph-PDE 1 0 0 0 0 6e+05 7.8913e-10 \ 1.9728e-10 9.8641e-10 1.2644e-09 1e-05 36 9 0 0 45 0 "" edit_enz red yellow \ CoComplex kpool enzproto_to_pool_link simundump kpool /kinetics/PP2A 1 0.17 0.12 0.12 1.3893e-13 72000 72000 \ 1.02e+05 0 6e+05 0 0 "" red black simundump kenz /kinetics/PP2A/PP2A-dephosph-I1 1 0 0 0 0 6e+05 0.024458 \ 0.00587 0.030328 0.030263 6.6e-06 25 6 0 0 31 0 "" edit_enz red red \ CoComplex kpool enzproto_to_pool_link simundump kenz /kinetics/PP2A/PP2A-dephosph-PP1-I* 1 0 0 0 0 6e+05 217.54 \ 52.209 269.75 268.96 6.6e-06 25 6 0 0 31 0 "" edit_enz red red CoComplex \ kpool enzproto_to_pool_link simundump kpool /kinetics/CaNAB-Ca4 1 1.6667e-06 0 0 3.3845e-18 0 0 1 0 6e+05 \ 0 1 "" tan yellow simundump kenz /kinetics/CaNAB-Ca4/dephosph_inhib1_noCaM 1 0 0 0 0 6e+05 \ 2.9428e-10 7.3569e-11 3.6785e-10 9.7653e-10 5.7e-08 0.136 0.034 0 0 0.17 0 \ "" edit_enz red tan CoComplex kpool enzproto_to_pool_link simundump group /kinetics/PP2B 1 "" edit_group red3 black x group 0 0 simundump kpool /kinetics/PP2B/CaNAB 1 25 1 1 6.6778e-11 6e+05 6e+05 1.5e+07 \ 0 6e+05 0 1 "" tan red3 simundump kpool /kinetics/PP2B/CaNAB-Ca2 1 1.6667e-06 0 0 0 0 0 1 0 6e+05 0 0 \ "" tan red3 simundump kreac /kinetics/PP2B/Ca-bind-CaNAB-Ca2 1 0.26898 0.35741 1e-11 1 1 \ 0 "" edit_reac white red3 A group simundump kreac /kinetics/PP2B/Ca-bind-CaNAB 1 23924 23926 2.78e-08 1 1 0 "" \ edit_reac white red3 A group simundump kreac /kinetics/PP2B/CaM-Ca2-bind-CaNAB 1 2.8431e-06 3.2871e-06 \ 4e-07 1 1 0 "" edit_reac white red3 A group simundump kpool /kinetics/PP2B/CaMCa3-CaNAB 1 1.6667e-06 0 0 4.6297e-18 0 0 1 \ 0 6e+05 0 0 "" blue red3 simundump kpool /kinetics/PP2B/CaMCa2-CANAB 1 1.6667e-06 0 0 4.6297e-18 0 0 1 \ 0 6e+05 0 0 "" blue red3 simundump kpool /kinetics/PP2B/CaMCa4-CaNAB 1 1.6667e-06 0 0 4.6297e-18 0 0 1 \ 0 6e+05 0 0 "" blue red3 simundump kreac /kinetics/PP2B/CaMCa3-bind-CaNAB 1 5.8415e-08 2.351e-08 \ 3.73e-06 1 1 0 "" edit_reac white red3 A group simundump kreac /kinetics/PP2B/CaMCa4-bind-CaNAB 1 2.4461e-11 4.987e-11 0.001 \ 1 1 0 "" edit_reac white red3 A group simundump group /kinetics/PKA 0 "" edit_group blue blue x group 0 0 simundump kpool /kinetics/PKA/R2C2 0 0.5 0.5 0.5 3.0222e-16 3e+05 3e+05 3e+05 \ 0 6e+05 0 1 "" white blue simundump kpool /kinetics/PKA/R2C2-cAMP 0 1 0 0 2.7775e-12 0 0 6e+05 0 6e+05 \ 0 1 "" white blue simundump kreac /kinetics/PKA/cAMP-bind-site-B1 0 2151.6 2335.1 9e-05 33 1 0 \ "" edit_reac white blue A group simundump kreac /kinetics/PKA/cAMP-bind-site-B2 1 0.43248 0.50761 9e-05 33 1 \ 0 "" edit_reac white blue A group simundump kreac /kinetics/PKA/cAMP-bind-site-A1 1 0.00013148 0.00014171 \ 0.000125 110 1 0 "" edit_reac white blue A group simundump kreac /kinetics/PKA/cAMP-bind-site-A2 1 4.0421e-09 1.2924e-08 \ 0.000125 32.5 1 0 "" edit_reac white blue A group simundump kpool /kinetics/PKA/R2C2-cAMP2 1 1.6667e-06 0 0 4.5688e-18 0 0 1 0 \ 6e+05 0 0 "" white blue simundump kpool /kinetics/PKA/R2C2-cAMP3 1 1.6667e-06 0 0 4.6297e-18 0 0 1 0 \ 6e+05 0 0 "" white blue simundump kpool /kinetics/PKA/R2C2-cAMP4 1 1.6667e-06 0 0 4.6297e-18 0 0 1 0 \ 6e+05 0 0 "" white blue simundump kpool /kinetics/PKA/R2C-cAMP4 1 1.6667e-06 0 0 4.6297e-18 0 0 1 0 \ 6e+05 0 0 "" white blue simundump kpool /kinetics/PKA/R2-cAMP4 1 0.15 0 0 4.1667e-13 0 0 90000 0 \ 6e+05 0 0 "" white blue simundump kreac /kinetics/PKA/Release-C1 1 1.4635e-24 7.4623e-09 60 3e-05 1 0 \ "" edit_reac white blue A group simundump kreac /kinetics/PKA/Release-C2 1 6.6749e-24 6.2502e-09 60 3e-05 1 0 \ "" edit_reac white blue A group simundump kpool /kinetics/PKA/PKA-inhibitor 1 1 0.25 0.25 2.0833e-12 1.5e+05 \ 1.5e+05 6e+05 0 6e+05 0 1 "" cyan blue simundump kreac /kinetics/PKA/inhib-PKA 1 4.761e-10 7.0245e-09 1e-04 1 1 0 "" \ edit_reac white blue A group simundump kpool /kinetics/PKA/inhibited-PKA 1 1.6667e-06 0 0 4.6297e-18 0 0 1 \ 0 6e+05 0 0 "" cyan blue simundump kpool /kinetics/cAMP 1 10 0 0 2.7778e-11 0 0 6e+06 0 6e+05 2 0 "" \ green black simundump group /kinetics/AC 1 "" edit_group blue blue x group 0 0 simundump kpool /kinetics/AC/ATP 1 5000 5000 5000 0 3e+09 3e+09 3e+09 0 6e+05 \ 4 0 "" red blue simundump kpool /kinetics/AC/AC1-CaM 1 1.6667e-06 0 0 4.6297e-18 0 0 1 0 \ 6e+05 0 0 "" orange blue simundump kenz /kinetics/AC/AC1-CaM/kenz 1 0 0 0 0 6e+05 7.8189e-06 \ 1.9547e-06 9.5017e+05 9.8499e-06 7.5e-06 72 18 0 1 90 0 "" edit_enz red \ orange CoComplex kpool enzproto_to_pool_link simundump kpool /kinetics/AC/AC1 1 1 0.02 0.02 2.7222e-12 12000 12000 6e+05 0 \ 6e+05 0 1 "" orange blue simundump kreac /kinetics/AC/CaM-bind-AC1 1 1.0903e-07 1.854e-07 8.3333e-05 1 \ 1 0 "" edit_reac white blue A group simundump kpool /kinetics/AC/AC2* 1 0.010851 0 0 2.9838e-14 0 0 6510.3 0 \ 6e+05 0 0 "" yellow blue simundump kenz /kinetics/AC/AC2*/kenz 1 0 0 0 0 6e+05 1822.5 455.63 0 2367.6 \ 2.9e-06 28 7 0 1 35 0 "" edit_enz red yellow CoComplex kpool \ enzproto_to_pool_link simundump kpool /kinetics/AC/AC2-Gs 1 1.6667e-06 0 0 4.6297e-18 0 0 1 0 6e+05 \ 0 0 "" yellow blue simundump kenz /kinetics/AC/AC2-Gs/kenz 1 0 0 0 0 6e+05 0 0 7.1263e+05 0 \ 7.5e-06 72 18 0 1 90 0 "" edit_enz red yellow CoComplex kpool \ enzproto_to_pool_link simundump kpool /kinetics/AC/AC2 1 0.015 0.015 0.015 4.1412e-16 9000 9000 \ 9000 0 6e+05 0 1 "" yellow blue simundump kreac /kinetics/AC/dephosph-AC2 1 0 6.5362 0.1 0 1 0 "" edit_reac \ white blue A group simundump kpool /kinetics/AC/AC1-Gs 1 1.6667e-06 0 0 4.6297e-18 0 0 1 0 6e+05 \ 0 0 "" orange blue simundump kenz /kinetics/AC/AC1-Gs/kenz 1 0 0 0 0 0 0 0 0 0 7.5e-06 72 18 0 1 \ 90 0 "" edit_enz red orange CoComplex kpool enzproto_to_pool_link simundump kreac /kinetics/AC/Gs-bind-AC2 1 0 0 0.00083333 1 1 0 "" edit_reac \ white blue A group simundump kreac /kinetics/AC/Gs-bind-AC1 1 0 0 0.00021 1 1 0 "" edit_reac \ white blue A group simundump kpool /kinetics/AC/AMP 1 3.2549e+05 3.2549e+05 3.2549e+05 0 \ 3.2549e+05 3.2549e+05 3.2549e+05 0 1 0 0 "" pink blue simundump kpool /kinetics/AC/AC2*-Gs 1 1.6667e-06 0 0 4.6297e-18 0 0 1 0 \ 6e+05 0 0 "" green blue simundump kenz /kinetics/AC/AC2*-Gs/kenz 1 0 0 0 0 0 0 0 7.2038e+05 0 7.5e-06 \ 216 54 0 1 270 0 "" edit_enz red green CoComplex kpool \ enzproto_to_pool_link simundump kreac /kinetics/AC/Gs-bind-AC2* 1 0 0 0.0013888 1 1 0 "" edit_reac \ white blue A group simundump kpool /kinetics/AC/cAMP-PDE 1 1 0.45 0.45 1.5278e-12 2.7e+05 \ 2.7e+05 6e+05 0 6e+05 0 0 "" green blue simundump kenz /kinetics/AC/cAMP-PDE/PDE 1 0 0 0 0 6e+05 74.35 18.587 92.937 \ 98.094 4.2e-06 40 10 0 0 50 0 "" edit_enz red green CoComplex kpool \ enzproto_to_pool_link simundump kpool /kinetics/AC/cAMP-PDE* 1 1.6667e-06 0 0 4.6297e-18 0 0 1 0 \ 6e+05 0 0 "" green blue simundump kenz /kinetics/AC/cAMP-PDE*/PDE* 1 0 0 0 0 6e+05 6.8389e-15 \ 1.7097e-15 8.5487e-15 1.0017e-14 8.4e-06 80 20 0 0 100 0 "" edit_enz red \ green CoComplex kpool enzproto_to_pool_link simundump kreac /kinetics/AC/dephosph-PDE 1 0 1.3786e-12 0.1 0 1 0 "" \ edit_reac white blue A group simundump kpool /kinetics/AC/PDE1 1 2 2 2 1.4677e-17 1.2e+06 1.2e+06 1.2e+06 \ 0 6e+05 0 0 "" green blue simundump kenz /kinetics/AC/PDE1/PDE1 1 0 0 0 0 6e+05 21.138 5.2828 26.42 \ 36.331 3.5e-07 6.67 1.667 0 0 8.337 0 "" edit_enz red green CoComplex kpool \ enzproto_to_pool_link simundump kpool /kinetics/AC/CaM.PDE1 1 1.6667e-06 0 0 4.6295e-18 0 0 1 0 \ 6e+05 0 0 "" green blue simundump kenz /kinetics/AC/CaM.PDE1/CaM.PDE1 1 0 0 0 0 6e+05 7.3792e-09 \ 1.8448e-09 9.2239e-09 9.7333e-09 2.1e-06 40 10 0 0 50 0 "" edit_enz red \ green CoComplex kpool enzproto_to_pool_link simundump kreac /kinetics/AC/CaM_bind_PDE1 1 0.0002679 0.00026698 0.0012 5 0 \ 0 "" edit_reac white blue A group simundump kpool /kinetics/Gs-alpha 1 0.01 0 0 2.7778e-14 0 0 6000 0 6e+05 2 0 \ "" red black simundump kpool /kinetics/tot_PP1 1 1.8 0 0 0 0 0 1.08e+06 0 6e+05 0 0 "" \ blue black simundump xtab /kinetics/Ca_tab 1 0 0 1 2 0 "" edit_xtab white red output \ group 0 0 0 3 loadtab /kinetics/Ca_tab table 1 100 0 100 \ 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 \ 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 \ 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 simundump kpool /kinetics/tot_CaMKII-active 1 0 0 0 0 0 0 0 0 6e+05 0 0 "" \ blue black simundump kpool /kinetics/tot_CaN-active 1 0 0 0 0 0 0 0 0 6e+05 0 0 "" red \ black simundump xgraph /graphs/conc1 0 0 10000 0 35 0 simundump xgraph /graphs/conc2 0 0 10000 0 1.2 0 simundump xplot /graphs/conc1/Ca.Co 3 524288 \ "delete_plot.w ; edit_plot.D " red 0 0 1 simundump xplot /graphs/conc1/tot_CaMKII-active.Co 3 524288 \ "delete_plot.w ; edit_plot.D " blue 0 0 1 simundump xplot /graphs/conc2/tot_CaN-active.Co 3 524288 \ "delete_plot.w ; edit_plot.D " red 0 0 1 simundump xgraph /moregraphs/conc3 0 0 10000 0 0.3 0 simundump xgraph /moregraphs/conc4 0 0 10000 0 1.6 0 simundump xplot /moregraphs/conc3/PKA-active.Co 3 524288 \ "delete_plot.w ; edit_plot.D " yellow 0 0 1 simundump xplot /moregraphs/conc4/tot_PP1.Co 3 524288 \ "delete_plot.w ; edit_plot.D " blue 0 0 1 simundump xcoredraw /edit/draw 0 -12.875 1.7438 -9.7046 4.9136 simundump xtree /edit/draw/tree 0 /kinetics/##[] \ "edit_elm.D ; drag_from_edit.w " auto 0.6 call /edit/draw/tree ADDMSGARROW \ select all all all none -1000 0 \ "" "" "" call /edit/draw/tree ADDMSGARROW \ /kinetics/##[] /kinetics/##[TYPE=group] all all none -1001 0 \ "echo.p dragging onto group ; thing_to_group_add.p " "" "" call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kpool] /kinetics/##[TYPE=kpool] SUMTOTAL kpool darkgreen -1002 0 \ "echo.p dragging to for sumtotal" "pool_to_pool_add_sumtot.p " "pool_to_pool_drop_sumtot.p " call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kpool] /kinetics/##[TYPE=kpool] CONSERVE kpool blue -1003 0 \ "echo.p dragging to for conserve" "pool_to_pool_add_consv.p " "pool_to_pool_drop_consv.p " call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kreac] /kinetics/##[TYPE=kpool] REAC kpool none -1004 0 \ "echo.p dragging to for product" "reac_to_pool_add.p " "reac_to_pool_drop.p " call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kpool] /kinetics/##[TYPE=kreac] SUBSTRATE kreac green -1005 0 \ "echo.p dragging to for substrate" "pool_to_reac_add.p " "pool_to_reac_drop.p " call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kpool] /kinetics/##[TYPE=kreac] KF kreac purple -1006 0 \ "" "" "" call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kpool] /kinetics/##[TYPE=kreac] KB kreac hotpink -1007 0 \ "" "" "" call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kpool] /kinetics/##[TYPE=kreac] PRODUCT kreac green -1008 1 \ "" "" "" call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kenz] /kinetics/##[TYPE=kpool] MM_PRD kpool red -1009 0 \ "echo.p dragging to for enz product" "enz_to_pool_add.p " "enz_to_pool_drop.p " call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kpool] /kinetics/##[TYPE=kenz] SUBSTRATE kenz red -1010 0 \ "echo.p dragging to for enz substrate" "pool_to_enz_add.p " "pool_to_enz_drop.p " call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kenz] /kinetics/##[TYPE=kpool] SUMTOTAL kpool darkgreen -1011 0 \ "" "" "" call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kenz] /kinetics/##[TYPE=kpool] CONSERVE kpool blue -1012 0 \ "" "" "" call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kpool] /kinetics/##[TYPE=kenz] INTRAMOL kenz white -1013 0 \ "" "" "" call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=stim] /kinetics/##[TYPE=kpool] SLAVE kpool orange -1014 0 \ "echo.p dragging to for stimulus" "stim_to_pool_add.p " "stim_to_pool_drop.p " call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=stim] /kinetics/##[TYPE=stim] INPUT stim orange -1015 0 \ "echo.p dragging to for stim" "stim_to_stim_add.p " "stim_to_stim_drop.p " call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=xtab] /kinetics/##[TYPE=kpool] SLAVE kpool orange -1016 0 \ "echo.p dragging to for xtab" "xtab_to_pool_add.p " "xtab_to_pool_drop.p " call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=xtab] /kinetics/##[TYPE=xtab] INPUT xtab orange -1017 0 \ "echo.p dragging to for xtab" "xtab_to_xtab_add.p " "xtab_to_xtab_drop.p " call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kpool] /kinetics/##[TYPE=xtab] INPUT xtab hotpink -1018 0 \ "echo.p dragging to for xtab" "pool_to_xtab_add.p " "pool_to_xtab_drop.p " call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kchan] /kinetics/##[TYPE=kpool] REAC kpool none -1019 0 \ "echo.p dragging to for chan product" "chan_to_pool_add.p " "chan_to_pool_drop.p " call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kpool] /kinetics/##[TYPE=kchan] PRODUCT kchan orange -1020 1 \ "" "" "" call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kpool] /kinetics/##[TYPE=kchan] SUBSTRATE kchan orange -1021 0 \ "echo.p dragging to for chan substrate" "pool_to_chan_add.p " "pool_to_chan_drop.p " call /edit/draw/tree UNDUMP 100 \ "/kinetics/CaMKII" 2.6875 3.72917 0 \ "/kinetics/CaMKII/CaMKII" 1.2692 3.0259 0 \ "/kinetics/CaMKII/CaMKII-CaM" -2.3548 2.7925 0 \ "/kinetics/CaMKII/CaMKII-thr286*-CaM" -2.6144 1.3705 0 \ "/kinetics/CaMKII/CaMKII***" -2.5276 -1.8689 0 \ "/kinetics/CaMKII/CaMKII-bind-CaM" 1.7899 1.2816 0 \ "/kinetics/CaMKII/CaMK-thr286-bind-CaM" 1.8116 0.67637 0 \ "/kinetics/CaMKII/CaMKII-thr286" -2.4625 -0.33819 0 \ "/kinetics/CaMKII/CaMK-thr306" -2.4506 -3.5103 0 \ "/kinetics/CaMKII/total-CaMKII" -2.7513 3.8942 0 \ "/kinetics/CaMKII/basal-activity" -0.28069 -0.40738 0 \ "/kinetics/CaMKII/tot_CaM_CaMKII" -6.627 3.0522 0 \ "/kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_305" -4.4631 0.3694 0 \ "/kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_286" -0.5082 2.5709 0 \ "/kinetics/CaMKII/tot_autonomous_CaMKII" -6.9754 2.0821 0 \ "/kinetics/CaMKII/tot_autonomous_CaMKII/auton_305" -4.6475 -0.65672 0 \ "/kinetics/CaMKII/tot_autonomous_CaMKII/auton_286" -0.38525 1.75 0 \ "/kinetics/CaM-Ca4" 3.0133 -3.112 0 \ "/kinetics/PP1-active" -6.36006 -0.105351 0 \ "/kinetics/PP1-active/Deph-thr286" -6.00854 1.5362 0 \ "/kinetics/PP1-active/Deph-thr305" -5.22505 -1.35033 0 \ "/kinetics/PP1-active/Deph-thr306" -0.44927 3.4772 0 \ "/kinetics/PP1-active/Deph-thr286c" -5.2457 -3.0616 0 \ "/kinetics/PP1-active/Deph_thr286b" 0.33058 -1.3636 0 \ "/kinetics/CaM" -20.2388 -3.85522 0 \ "/kinetics/CaM/CaM" -20.2558 3.86448 0 \ "/kinetics/CaM/CaM-TR2-bind-Ca" -18.0769 3.22368 0 \ "/kinetics/CaM/CaM-TR2-Ca2-bind-Ca" -19.081 1.37008 0 \ "/kinetics/CaM/CaM-Ca3-bind-Ca" -20.6385 -1.59562 0 \ "/kinetics/CaM/neurogranin-CaM" -29.8497 -4.38352 0 \ "/kinetics/CaM/neurogranin-bind-CaM" -25.8694 -3.94642 0 \ "/kinetics/CaM/neurogranin*" -22.7817 -7.05092 0 \ "/kinetics/CaM/neurogranin" -27.4802 -7.06122 0 \ "/kinetics/CaM/dephosph-neurogranin" -20.667 -5.3862 0 \ "/kinetics/Ca" -12.573 -0.45824 0 \ "/kinetics/PKC-active" 14.665 -0.98951 0 \ "/kinetics/PKC-active/PKC-phosph-neurogranin" -23.917 -4.6577 0 \ "/kinetics/PKC-active/PKC-phosph-ng-CaM" -27.353 -1.8725 0 \ "/kinetics/PKC-active/phosph-AC2" 8.2737 -21.525 0 \ "/kinetics/CaM-Ca3" -16.75 -0.45824 0 \ "/kinetics/CaM-TR2-Ca2" -15.24 2.4025 0 \ "/kinetics/CaM(Ca)n-CaNAB" -5.4358 -6.8994 0 \ "/kinetics/CaM(Ca)n-CaNAB/dephosph_neurogranin" -25.959 -9.4632 0 \ "/kinetics/CaM(Ca)n-CaNAB/dephosph_inhib1" -17.654 -17.602 0 \ "/kinetics/CaM(Ca)n-CaNAB/dephosph-PP1-I*" -16.152 -6.6886 0 \ "/kinetics/PP1" -21.274 -10.48 0 \ "/kinetics/PP1/I1" -12.9252 -14.5964 0 \ "/kinetics/PP1/I1*" -17.0695 -14.5644 0 \ "/kinetics/PP1/Inact-PP1" -20.315 -12.6624 0 \ "/kinetics/PP1/PP1-I1*" -18.659 -9.2092 0 \ "/kinetics/PP1/PP1-I1" -11.2507 -8.933 0 \ "/kinetics/PP1/dissoc-PP1-I1" -17.41 -12.3861 0 \ "/kinetics/PKA-active" -8.4971 -13.103 0 \ "/kinetics/PKA-active/PKA-phosph-I1" -11.806 -17.359 0 \ "/kinetics/PKA-active/PKA-phosph-GAP" -8.8035 -19.992 0 \ "/kinetics/PKA-active/phosph-PDE" -5.8456 -13.562 0 \ "/kinetics/PP2A" -11.432 -3.8776 0 \ "/kinetics/PP2A/PP2A-dephosph-I1" -13.866 -10.9083 0 \ "/kinetics/PP2A/PP2A-dephosph-PP1-I*" -11.433 -5.0184 0 \ "/kinetics/CaNAB-Ca4" 0.16478 -8.8168 0 \ "/kinetics/CaNAB-Ca4/dephosph_inhib1_noCaM" -10.451 -10.741 0 \ "/kinetics/PP2B" 5.0358 -6.0997 0 \ "/kinetics/PP2B/CaNAB" 6.3861 -8.6907 0 \ "/kinetics/PP2B/CaNAB-Ca2" 3.8301 -8.7824 0 \ "/kinetics/PP2B/Ca-bind-CaNAB-Ca2" 2.2627 -9.9976 0 \ "/kinetics/PP2B/Ca-bind-CaNAB" 4.9634 -10.135 0 \ "/kinetics/PP2B/CaM-Ca2-bind-CaNAB" -1.8742 -9.5607 0 \ "/kinetics/PP2B/CaMCa3-CaNAB" -4.5792 -10.999 0 \ "/kinetics/PP2B/CaMCa2-CANAB" -2.4377 -10.934 0 \ "/kinetics/PP2B/CaMCa4-CaNAB" -5.9091 -9.8612 0 \ "/kinetics/PP2B/CaMCa3-bind-CaNAB" -2.5053 -8.8524 0 \ "/kinetics/PP2B/CaMCa4-bind-CaNAB" -2.5504 -7.8866 0 \ "/kinetics/PKA" -16.855 -20.912 0 \ "/kinetics/PKA/R2C2" -21.5674 -27.9846 0 \ "/kinetics/PKA/R2C2-cAMP" -18.6055 -27.5168 0 \ "/kinetics/PKA/cAMP-bind-site-B1" -19.191 -31.2597 0 \ "/kinetics/PKA/cAMP-bind-site-B2" -16.8491 -30.0121 0 \ "/kinetics/PKA/cAMP-bind-site-A1" -14.1627 -31.1973 0 \ "/kinetics/PKA/cAMP-bind-site-A2" -10.8755 -29.7661 0 \ "/kinetics/PKA/R2C2-cAMP2" -15.0582 -26.6746 0 \ "/kinetics/PKA/R2C2-cAMP3" -12.3718 -27.7351 0 \ "/kinetics/PKA/R2C2-cAMP4" -9.9853 -26.124 0 \ "/kinetics/PKA/R2C-cAMP4" -12.2685 -24.9903 0 \ "/kinetics/PKA/R2-cAMP4" -18.6055 -25.4269 0 \ "/kinetics/PKA/Release-C1" -10.2729 -23.122 0 \ "/kinetics/PKA/Release-C2" -15.1439 -24.4 0 \ "/kinetics/PKA/PKA-inhibitor" -19.6257 -23.5329 0 \ "/kinetics/PKA/inhib-PKA" -16.8325 -22.9096 0 \ "/kinetics/PKA/inhibited-PKA" -20.2527 -21.934 0 \ "/kinetics/cAMP" -5.0683 -32.836 0 \ "/kinetics/AC" 7.5593 -17.715 0 \ "/kinetics/AC/ATP" 7.0461 -19.113 0 \ "/kinetics/AC/AC1-CaM" 4.6056 -17.504 0 \ "/kinetics/AC/AC1-CaM/kenz" 4.5678 -18.639 0 \ "/kinetics/AC/AC1" 0.8408 -15.6391 0 \ "/kinetics/AC/CaM-bind-AC1" 2.326 -15.8346 0 \ "/kinetics/AC/AC2*" 6.441 -22.765 0 \ "/kinetics/AC/AC2*/kenz" 6.3147 -21.908 0 \ "/kinetics/AC/AC2-Gs" 3.6027 -21.954 0 \ "/kinetics/AC/AC2-Gs/kenz" 3.5238 -20.946 0 call /edit/draw/tree UNDUMP 25 \ "/kinetics/AC/AC2" 7.4818 -24.548 0 \ "/kinetics/AC/dephosph-AC2" 5.3295 -25.353 0 \ "/kinetics/AC/AC1-Gs" 2.168 -16.752 0 \ "/kinetics/AC/AC1-Gs/kenz" 3.1436 -17.9 0 \ "/kinetics/AC/Gs-bind-AC2" 4.9182 -27.387 0 \ "/kinetics/AC/Gs-bind-AC1" 0.2088 -17.128 0 \ "/kinetics/AC/AMP" 1.4388 -17.715 0 \ "/kinetics/AC/AC2*-Gs" 4.9462 -22.386 0 \ "/kinetics/AC/AC2*-Gs/kenz" 5.0219 -21.332 0 \ "/kinetics/AC/Gs-bind-AC2*" 4.745 -24.236 0 \ "/kinetics/AC/cAMP-PDE" -1.6237 -15.941 0 \ "/kinetics/AC/cAMP-PDE/PDE" -1.7324 -23.376 0 \ "/kinetics/AC/cAMP-PDE*" -1.5969 -18.025 0 \ "/kinetics/AC/cAMP-PDE*/PDE*" -0.3498 -22.55 0 \ "/kinetics/AC/dephosph-PDE" -3.4985 -19.087 0 \ "/kinetics/AC/PDE1" -5.4043 -12.3603 0 \ "/kinetics/AC/PDE1/PDE1" -2.3373 -22.314 0 \ "/kinetics/AC/CaM.PDE1" -5.4043 -15.095 0 \ "/kinetics/AC/CaM.PDE1/CaM.PDE1" -3.2447 -21.527 0 \ "/kinetics/AC/CaM_bind_PDE1" -2.1917 -13.538 0 \ "/kinetics/Gs-alpha" 1.4111 -28.275 0 \ "/kinetics/tot_PP1" -11.456 1.2131 0 \ "/kinetics/Ca_tab" -12.713 2.8136 0 \ "/kinetics/tot_CaMKII-active" -11.365 4.2863 0 \ "/kinetics/tot_CaN-active" -8.861 -8.5101 0 simundump xtext /file/notes 0 1 xtextload /file/notes \ "Merged in ac19.g on top of" \ "allcam35.g to add in" \ "CaM-dependent PDE" \ "Added in a few plots and a stimulus" \ "table to allcam36.g" \ "Eliminated notes for portability." addmsg /kinetics/CaMKII/CaMKII-bind-CaM /kinetics/CaMKII/CaMKII REAC A B addmsg /kinetics/PP1-active/Deph-thr306 /kinetics/CaMKII/CaMKII MM_PRD pA addmsg /kinetics/PP1-active/Deph_thr286b /kinetics/CaMKII/CaMKII MM_PRD pA addmsg /kinetics/CaMKII/basal-activity /kinetics/CaMKII/CaMKII REAC A B addmsg /kinetics/CaMKII/CaMKII-bind-CaM /kinetics/CaMKII/CaMKII-CaM REAC B A addmsg /kinetics/PP1-active/Deph-thr286 /kinetics/CaMKII/CaMKII-CaM MM_PRD pA addmsg /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_286 /kinetics/CaMKII/CaMKII-CaM REAC sA B addmsg /kinetics/CaMKII/tot_autonomous_CaMKII/auton_286 /kinetics/CaMKII/CaMKII-CaM REAC sA B addmsg /kinetics/CaMKII/CaMK-thr286-bind-CaM /kinetics/CaMKII/CaMKII-thr286*-CaM REAC B A addmsg /kinetics/PP1-active/Deph-thr286 /kinetics/CaMKII/CaMKII-thr286*-CaM REAC sA B addmsg /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_286 /kinetics/CaMKII/CaMKII-thr286*-CaM MM_PRD pA addmsg /kinetics/CaMKII/tot_autonomous_CaMKII/auton_286 /kinetics/CaMKII/CaMKII-thr286*-CaM MM_PRD pA addmsg /kinetics/PP1-active/Deph-thr305 /kinetics/CaMKII/CaMKII*** REAC sA B addmsg /kinetics/PP1-active/Deph-thr286c /kinetics/CaMKII/CaMKII*** REAC sA B addmsg /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_305 /kinetics/CaMKII/CaMKII*** MM_PRD pA addmsg /kinetics/CaMKII/tot_autonomous_CaMKII/auton_305 /kinetics/CaMKII/CaMKII*** MM_PRD pA addmsg /kinetics/CaM-Ca4 /kinetics/CaMKII/CaMKII-bind-CaM SUBSTRATE n addmsg /kinetics/CaMKII/CaMKII /kinetics/CaMKII/CaMKII-bind-CaM SUBSTRATE n addmsg /kinetics/CaMKII/CaMKII-CaM /kinetics/CaMKII/CaMKII-bind-CaM PRODUCT n addmsg /kinetics/CaMKII/CaMKII-thr286 /kinetics/CaMKII/CaMK-thr286-bind-CaM SUBSTRATE n addmsg /kinetics/CaM-Ca4 /kinetics/CaMKII/CaMK-thr286-bind-CaM SUBSTRATE n addmsg /kinetics/CaMKII/CaMKII-thr286*-CaM /kinetics/CaMKII/CaMK-thr286-bind-CaM PRODUCT n addmsg /kinetics/CaMKII/CaMK-thr286-bind-CaM /kinetics/CaMKII/CaMKII-thr286 REAC A B addmsg /kinetics/PP1-active/Deph-thr305 /kinetics/CaMKII/CaMKII-thr286 MM_PRD pA addmsg /kinetics/PP1-active/Deph_thr286b /kinetics/CaMKII/CaMKII-thr286 REAC sA B addmsg /kinetics/CaMKII/basal-activity /kinetics/CaMKII/CaMKII-thr286 REAC B A addmsg /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_305 /kinetics/CaMKII/CaMKII-thr286 REAC sA B addmsg /kinetics/CaMKII/tot_autonomous_CaMKII/auton_305 /kinetics/CaMKII/CaMKII-thr286 REAC sA B addmsg /kinetics/PP1-active/Deph-thr306 /kinetics/CaMKII/CaMK-thr306 REAC sA B addmsg /kinetics/PP1-active/Deph-thr286c /kinetics/CaMKII/CaMK-thr306 MM_PRD pA addmsg /kinetics/CaMKII/CaMKII /kinetics/CaMKII/basal-activity SUBSTRATE n addmsg /kinetics/CaMKII/CaMKII-thr286 /kinetics/CaMKII/basal-activity PRODUCT n addmsg /kinetics/CaMKII/CaMKII-CaM /kinetics/CaMKII/tot_CaM_CaMKII SUMTOTAL n nInit addmsg /kinetics/CaMKII/CaMKII-thr286*-CaM /kinetics/CaMKII/tot_CaM_CaMKII SUMTOTAL n nInit addmsg /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_305 /kinetics/CaMKII/tot_CaM_CaMKII REAC eA B addmsg /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_286 /kinetics/CaMKII/tot_CaM_CaMKII REAC eA B addmsg /kinetics/CaMKII/tot_CaM_CaMKII /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_305 ENZYME n addmsg /kinetics/CaMKII/CaMKII-thr286 /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_305 SUBSTRATE n addmsg /kinetics/CaMKII/total-CaMKII /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_305 INTRAMOL n addmsg /kinetics/CaMKII/tot_CaM_CaMKII /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_286 ENZYME n addmsg /kinetics/CaMKII/CaMKII-CaM /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_286 SUBSTRATE n addmsg /kinetics/CaMKII/total-CaMKII /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_286 INTRAMOL n addmsg /kinetics/CaMKII/CaMKII-thr286 /kinetics/CaMKII/tot_autonomous_CaMKII SUMTOTAL n nInit addmsg /kinetics/CaMKII/CaMKII*** /kinetics/CaMKII/tot_autonomous_CaMKII SUMTOTAL n nInit addmsg /kinetics/CaMKII/tot_autonomous_CaMKII/auton_305 /kinetics/CaMKII/tot_autonomous_CaMKII REAC eA B addmsg /kinetics/CaMKII/tot_autonomous_CaMKII/auton_286 /kinetics/CaMKII/tot_autonomous_CaMKII REAC eA B addmsg /kinetics/CaMKII/tot_autonomous_CaMKII /kinetics/CaMKII/tot_autonomous_CaMKII/auton_305 ENZYME n addmsg /kinetics/CaMKII/CaMKII-thr286 /kinetics/CaMKII/tot_autonomous_CaMKII/auton_305 SUBSTRATE n addmsg /kinetics/CaMKII/total-CaMKII /kinetics/CaMKII/tot_autonomous_CaMKII/auton_305 INTRAMOL n addmsg /kinetics/CaMKII/tot_autonomous_CaMKII /kinetics/CaMKII/tot_autonomous_CaMKII/auton_286 ENZYME n addmsg /kinetics/CaMKII/CaMKII-CaM /kinetics/CaMKII/tot_autonomous_CaMKII/auton_286 SUBSTRATE n addmsg /kinetics/CaMKII/total-CaMKII /kinetics/CaMKII/tot_autonomous_CaMKII/auton_286 INTRAMOL n addmsg /kinetics/CaMKII/CaMKII-bind-CaM /kinetics/CaM-Ca4 REAC A B addmsg /kinetics/CaMKII/CaMK-thr286-bind-CaM /kinetics/CaM-Ca4 REAC A B addmsg /kinetics/CaM/CaM-Ca3-bind-Ca /kinetics/CaM-Ca4 REAC B A addmsg /kinetics/PP2B/CaMCa4-bind-CaNAB /kinetics/CaM-Ca4 REAC A B addmsg /kinetics/AC/CaM-bind-AC1 /kinetics/CaM-Ca4 REAC A B addmsg /kinetics/AC/CaM_bind_PDE1 /kinetics/CaM-Ca4 REAC A B addmsg /kinetics/PP1-active/Deph-thr286 /kinetics/PP1-active REAC eA B addmsg /kinetics/PP1-active/Deph-thr305 /kinetics/PP1-active REAC eA B addmsg /kinetics/PP1-active/Deph-thr306 /kinetics/PP1-active REAC eA B addmsg /kinetics/PP1-active/Deph_thr286b /kinetics/PP1-active REAC eA B addmsg /kinetics/PP1-active/Deph-thr286c /kinetics/PP1-active REAC eA B addmsg /kinetics/PP1/Inact-PP1 /kinetics/PP1-active REAC A B addmsg /kinetics/PP1/dissoc-PP1-I1 /kinetics/PP1-active REAC B A addmsg /kinetics/PP1-active /kinetics/PP1-active/Deph-thr286 ENZYME n addmsg /kinetics/CaMKII/CaMKII-thr286*-CaM /kinetics/PP1-active/Deph-thr286 SUBSTRATE n addmsg /kinetics/PP1-active /kinetics/PP1-active/Deph-thr305 ENZYME n addmsg /kinetics/CaMKII/CaMKII*** /kinetics/PP1-active/Deph-thr305 SUBSTRATE n addmsg /kinetics/PP1-active /kinetics/PP1-active/Deph-thr306 ENZYME n addmsg /kinetics/CaMKII/CaMK-thr306 /kinetics/PP1-active/Deph-thr306 SUBSTRATE n addmsg /kinetics/PP1-active /kinetics/PP1-active/Deph-thr286c ENZYME n addmsg /kinetics/CaMKII/CaMKII*** /kinetics/PP1-active/Deph-thr286c SUBSTRATE n addmsg /kinetics/PP1-active /kinetics/PP1-active/Deph_thr286b ENZYME n addmsg /kinetics/CaMKII/CaMKII-thr286 /kinetics/PP1-active/Deph_thr286b SUBSTRATE n addmsg /kinetics/CaM/CaM-TR2-bind-Ca /kinetics/CaM/CaM REAC A B addmsg /kinetics/CaM/neurogranin-bind-CaM /kinetics/CaM/CaM REAC A B addmsg /kinetics/PKC-active/PKC-phosph-ng-CaM /kinetics/CaM/CaM MM_PRD pA addmsg /kinetics/CaM/CaM /kinetics/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/CaM-TR2-Ca2 /kinetics/CaM/CaM-TR2-bind-Ca PRODUCT n addmsg /kinetics/Ca /kinetics/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/Ca /kinetics/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/CaM-TR2-Ca2 /kinetics/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/Ca /kinetics/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/CaM-Ca3 /kinetics/CaM/CaM-TR2-Ca2-bind-Ca PRODUCT n addmsg /kinetics/CaM-Ca3 /kinetics/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/Ca /kinetics/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/CaM-Ca4 /kinetics/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/CaM/neurogranin-bind-CaM /kinetics/CaM/neurogranin-CaM REAC B A addmsg /kinetics/PKC-active/PKC-phosph-ng-CaM /kinetics/CaM/neurogranin-CaM REAC sA B addmsg /kinetics/CaM/neurogranin /kinetics/CaM/neurogranin-bind-CaM SUBSTRATE n addmsg /kinetics/CaM/neurogranin-CaM /kinetics/CaM/neurogranin-bind-CaM PRODUCT n addmsg /kinetics/CaM/CaM /kinetics/CaM/neurogranin-bind-CaM SUBSTRATE n addmsg /kinetics/CaM(Ca)n-CaNAB/dephosph_neurogranin /kinetics/CaM/neurogranin* REAC sA B addmsg /kinetics/PKC-active/PKC-phosph-neurogranin /kinetics/CaM/neurogranin* MM_PRD pA addmsg /kinetics/PKC-active/PKC-phosph-ng-CaM /kinetics/CaM/neurogranin* MM_PRD pA addmsg /kinetics/CaM/dephosph-neurogranin /kinetics/CaM/neurogranin* REAC A B addmsg /kinetics/CaM(Ca)n-CaNAB/dephosph_neurogranin /kinetics/CaM/neurogranin MM_PRD pA addmsg /kinetics/CaM/neurogranin-bind-CaM /kinetics/CaM/neurogranin REAC A B addmsg /kinetics/PKC-active/PKC-phosph-neurogranin /kinetics/CaM/neurogranin REAC sA B addmsg /kinetics/CaM/dephosph-neurogranin /kinetics/CaM/neurogranin REAC B A addmsg /kinetics/CaM/neurogranin* /kinetics/CaM/dephosph-neurogranin SUBSTRATE n addmsg /kinetics/CaM/neurogranin /kinetics/CaM/dephosph-neurogranin PRODUCT n addmsg /kinetics/CaM/CaM-TR2-bind-Ca /kinetics/Ca REAC A B addmsg /kinetics/CaM/CaM-TR2-bind-Ca /kinetics/Ca REAC A B addmsg /kinetics/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/Ca REAC A B addmsg /kinetics/CaM/CaM-Ca3-bind-Ca /kinetics/Ca REAC A B addmsg /kinetics/PP2B/Ca-bind-CaNAB-Ca2 /kinetics/Ca REAC A B addmsg /kinetics/PP2B/Ca-bind-CaNAB-Ca2 /kinetics/Ca REAC A B addmsg /kinetics/PP2B/Ca-bind-CaNAB /kinetics/Ca REAC A B addmsg /kinetics/PP2B/Ca-bind-CaNAB /kinetics/Ca REAC A B addmsg /kinetics/Ca_tab /kinetics/Ca SLAVE output addmsg /kinetics/PKC-active/PKC-phosph-neurogranin /kinetics/PKC-active REAC eA B addmsg /kinetics/PKC-active/PKC-phosph-ng-CaM /kinetics/PKC-active REAC eA B addmsg /kinetics/PKC-active/phosph-AC2 /kinetics/PKC-active REAC eA B addmsg /kinetics/PKC-active /kinetics/PKC-active/PKC-phosph-neurogranin ENZYME n addmsg /kinetics/CaM/neurogranin /kinetics/PKC-active/PKC-phosph-neurogranin SUBSTRATE n addmsg /kinetics/PKC-active /kinetics/PKC-active/PKC-phosph-ng-CaM ENZYME n addmsg /kinetics/CaM/neurogranin-CaM /kinetics/PKC-active/PKC-phosph-ng-CaM SUBSTRATE n addmsg /kinetics/PKC-active /kinetics/PKC-active/phosph-AC2 ENZYME n addmsg /kinetics/AC/AC2 /kinetics/PKC-active/phosph-AC2 SUBSTRATE n addmsg /kinetics/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/CaM-Ca3 REAC B A addmsg /kinetics/CaM/CaM-Ca3-bind-Ca /kinetics/CaM-Ca3 REAC A B addmsg /kinetics/PP2B/CaMCa3-bind-CaNAB /kinetics/CaM-Ca3 REAC A B addmsg /kinetics/CaM/CaM-TR2-bind-Ca /kinetics/CaM-TR2-Ca2 REAC B A addmsg /kinetics/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/CaM-TR2-Ca2 REAC A B addmsg /kinetics/PP2B/CaM-Ca2-bind-CaNAB /kinetics/CaM-TR2-Ca2 REAC A B addmsg /kinetics/CaM(Ca)n-CaNAB/dephosph_neurogranin /kinetics/CaM(Ca)n-CaNAB REAC eA B addmsg /kinetics/CaM(Ca)n-CaNAB/dephosph_inhib1 /kinetics/CaM(Ca)n-CaNAB REAC eA B addmsg /kinetics/CaM(Ca)n-CaNAB/dephosph-PP1-I* /kinetics/CaM(Ca)n-CaNAB REAC eA B addmsg /kinetics/PP2B/CaMCa4-CaNAB /kinetics/CaM(Ca)n-CaNAB SUMTOTAL n nInit addmsg /kinetics/PP2B/CaMCa3-CaNAB /kinetics/CaM(Ca)n-CaNAB SUMTOTAL n nInit addmsg /kinetics/PP2B/CaMCa2-CANAB /kinetics/CaM(Ca)n-CaNAB SUMTOTAL n nInit addmsg /kinetics/CaM(Ca)n-CaNAB /kinetics/CaM(Ca)n-CaNAB/dephosph_neurogranin ENZYME n addmsg /kinetics/CaM/neurogranin* /kinetics/CaM(Ca)n-CaNAB/dephosph_neurogranin SUBSTRATE n addmsg /kinetics/CaM(Ca)n-CaNAB /kinetics/CaM(Ca)n-CaNAB/dephosph_inhib1 ENZYME n addmsg /kinetics/PP1/I1* /kinetics/CaM(Ca)n-CaNAB/dephosph_inhib1 SUBSTRATE n addmsg /kinetics/CaM(Ca)n-CaNAB /kinetics/CaM(Ca)n-CaNAB/dephosph-PP1-I* ENZYME n addmsg /kinetics/PP1/PP1-I1* /kinetics/CaM(Ca)n-CaNAB/dephosph-PP1-I* SUBSTRATE n addmsg /kinetics/PKA-active/PKA-phosph-I1 /kinetics/PP1/I1 REAC sA B addmsg /kinetics/CaNAB-Ca4/dephosph_inhib1_noCaM /kinetics/PP1/I1 MM_PRD pA addmsg /kinetics/CaM(Ca)n-CaNAB/dephosph_inhib1 /kinetics/PP1/I1 MM_PRD pA addmsg /kinetics/PP2A/PP2A-dephosph-I1 /kinetics/PP1/I1 MM_PRD pA addmsg /kinetics/PP1/dissoc-PP1-I1 /kinetics/PP1/I1 REAC B A addmsg /kinetics/PP1/Inact-PP1 /kinetics/PP1/I1* REAC A B addmsg /kinetics/PKA-active/PKA-phosph-I1 /kinetics/PP1/I1* MM_PRD pA addmsg /kinetics/CaNAB-Ca4/dephosph_inhib1_noCaM /kinetics/PP1/I1* REAC sA B addmsg /kinetics/CaM(Ca)n-CaNAB/dephosph_inhib1 /kinetics/PP1/I1* REAC sA B addmsg /kinetics/PP2A/PP2A-dephosph-I1 /kinetics/PP1/I1* REAC sA B addmsg /kinetics/PP1/PP1-I1* /kinetics/PP1/Inact-PP1 PRODUCT n addmsg /kinetics/PP1/I1* /kinetics/PP1/Inact-PP1 SUBSTRATE n addmsg /kinetics/PP1-active /kinetics/PP1/Inact-PP1 SUBSTRATE n addmsg /kinetics/PP1/Inact-PP1 /kinetics/PP1/PP1-I1* REAC B A addmsg /kinetics/PP2A/PP2A-dephosph-PP1-I* /kinetics/PP1/PP1-I1* REAC sA B addmsg /kinetics/CaM(Ca)n-CaNAB/dephosph-PP1-I* /kinetics/PP1/PP1-I1* REAC sA B addmsg /kinetics/PP1/dissoc-PP1-I1 /kinetics/PP1/PP1-I1 REAC A B addmsg /kinetics/PP2A/PP2A-dephosph-PP1-I* /kinetics/PP1/PP1-I1 MM_PRD pA addmsg /kinetics/CaM(Ca)n-CaNAB/dephosph-PP1-I* /kinetics/PP1/PP1-I1 MM_PRD pA addmsg /kinetics/PP1/PP1-I1 /kinetics/PP1/dissoc-PP1-I1 SUBSTRATE n addmsg /kinetics/PP1-active /kinetics/PP1/dissoc-PP1-I1 PRODUCT n addmsg /kinetics/PP1/I1 /kinetics/PP1/dissoc-PP1-I1 PRODUCT n addmsg /kinetics/PKA-active/PKA-phosph-I1 /kinetics/PKA-active REAC eA B addmsg /kinetics/PKA/Release-C1 /kinetics/PKA-active REAC B A addmsg /kinetics/PKA/Release-C2 /kinetics/PKA-active REAC B A addmsg /kinetics/PKA/inhib-PKA /kinetics/PKA-active REAC A B addmsg /kinetics/PKA-active/PKA-phosph-GAP /kinetics/PKA-active REAC eA B addmsg /kinetics/PKA-active/phosph-PDE /kinetics/PKA-active REAC eA B addmsg /kinetics/PKA-active /kinetics/PKA-active/PKA-phosph-I1 ENZYME n addmsg /kinetics/PP1/I1 /kinetics/PKA-active/PKA-phosph-I1 SUBSTRATE n addmsg /kinetics/PKA-active /kinetics/PKA-active/PKA-phosph-GAP ENZYME n addmsg /kinetics/PKA-active /kinetics/PKA-active/phosph-PDE ENZYME n addmsg /kinetics/AC/cAMP-PDE /kinetics/PKA-active/phosph-PDE SUBSTRATE n addmsg /kinetics/PP2A/PP2A-dephosph-I1 /kinetics/PP2A REAC eA B addmsg /kinetics/PP2A/PP2A-dephosph-PP1-I* /kinetics/PP2A REAC eA B addmsg /kinetics/PP2A /kinetics/PP2A/PP2A-dephosph-I1 ENZYME n addmsg /kinetics/PP1/I1* /kinetics/PP2A/PP2A-dephosph-I1 SUBSTRATE n addmsg /kinetics/PP2A /kinetics/PP2A/PP2A-dephosph-PP1-I* ENZYME n addmsg /kinetics/PP1/PP1-I1* /kinetics/PP2A/PP2A-dephosph-PP1-I* SUBSTRATE n addmsg /kinetics/CaNAB-Ca4/dephosph_inhib1_noCaM /kinetics/CaNAB-Ca4 REAC eA B addmsg /kinetics/PP2B/Ca-bind-CaNAB-Ca2 /kinetics/CaNAB-Ca4 REAC B A addmsg /kinetics/PP2B/CaM-Ca2-bind-CaNAB /kinetics/CaNAB-Ca4 REAC A B addmsg /kinetics/PP2B/CaMCa4-bind-CaNAB /kinetics/CaNAB-Ca4 REAC A B addmsg /kinetics/PP2B/CaMCa3-bind-CaNAB /kinetics/CaNAB-Ca4 REAC A B addmsg /kinetics/CaNAB-Ca4 /kinetics/CaNAB-Ca4/dephosph_inhib1_noCaM ENZYME n addmsg /kinetics/PP1/I1* /kinetics/CaNAB-Ca4/dephosph_inhib1_noCaM SUBSTRATE n addmsg /kinetics/PP2B/Ca-bind-CaNAB /kinetics/PP2B/CaNAB REAC A B addmsg /kinetics/PP2B/Ca-bind-CaNAB /kinetics/PP2B/CaNAB-Ca2 REAC B A addmsg /kinetics/PP2B/Ca-bind-CaNAB-Ca2 /kinetics/PP2B/CaNAB-Ca2 REAC A B addmsg /kinetics/CaNAB-Ca4 /kinetics/PP2B/Ca-bind-CaNAB-Ca2 PRODUCT n addmsg /kinetics/Ca /kinetics/PP2B/Ca-bind-CaNAB-Ca2 SUBSTRATE n addmsg /kinetics/Ca /kinetics/PP2B/Ca-bind-CaNAB-Ca2 SUBSTRATE n addmsg /kinetics/PP2B/CaNAB-Ca2 /kinetics/PP2B/Ca-bind-CaNAB-Ca2 SUBSTRATE n addmsg /kinetics/PP2B/CaNAB /kinetics/PP2B/Ca-bind-CaNAB SUBSTRATE n addmsg /kinetics/PP2B/CaNAB-Ca2 /kinetics/PP2B/Ca-bind-CaNAB PRODUCT n addmsg /kinetics/Ca /kinetics/PP2B/Ca-bind-CaNAB SUBSTRATE n addmsg /kinetics/Ca /kinetics/PP2B/Ca-bind-CaNAB SUBSTRATE n addmsg /kinetics/CaNAB-Ca4 /kinetics/PP2B/CaM-Ca2-bind-CaNAB SUBSTRATE n addmsg /kinetics/CaM-TR2-Ca2 /kinetics/PP2B/CaM-Ca2-bind-CaNAB SUBSTRATE n addmsg /kinetics/PP2B/CaMCa2-CANAB /kinetics/PP2B/CaM-Ca2-bind-CaNAB PRODUCT n addmsg /kinetics/PP2B/CaMCa3-bind-CaNAB /kinetics/PP2B/CaMCa3-CaNAB REAC B A addmsg /kinetics/PP2B/CaM-Ca2-bind-CaNAB /kinetics/PP2B/CaMCa2-CANAB REAC B A addmsg /kinetics/PP2B/CaMCa4-bind-CaNAB /kinetics/PP2B/CaMCa4-CaNAB REAC B A addmsg /kinetics/PP2B/CaMCa3-CaNAB /kinetics/PP2B/CaMCa3-bind-CaNAB PRODUCT n addmsg /kinetics/CaM-Ca3 /kinetics/PP2B/CaMCa3-bind-CaNAB SUBSTRATE n addmsg /kinetics/CaNAB-Ca4 /kinetics/PP2B/CaMCa3-bind-CaNAB SUBSTRATE n addmsg /kinetics/PP2B/CaMCa4-CaNAB /kinetics/PP2B/CaMCa4-bind-CaNAB PRODUCT n addmsg /kinetics/CaM-Ca4 /kinetics/PP2B/CaMCa4-bind-CaNAB SUBSTRATE n addmsg /kinetics/CaNAB-Ca4 /kinetics/PP2B/CaMCa4-bind-CaNAB SUBSTRATE n addmsg /kinetics/PKA/cAMP-bind-site-B1 /kinetics/PKA/R2C2 REAC A B addmsg /kinetics/PKA/cAMP-bind-site-B1 /kinetics/PKA/R2C2-cAMP REAC B A addmsg /kinetics/PKA/cAMP-bind-site-B2 /kinetics/PKA/R2C2-cAMP REAC A B addmsg /kinetics/PKA/R2C2 /kinetics/PKA/cAMP-bind-site-B1 SUBSTRATE n addmsg /kinetics/PKA/R2C2-cAMP /kinetics/PKA/cAMP-bind-site-B1 PRODUCT n addmsg /kinetics/cAMP /kinetics/PKA/cAMP-bind-site-B1 SUBSTRATE n addmsg /kinetics/PKA/R2C2-cAMP /kinetics/PKA/cAMP-bind-site-B2 SUBSTRATE n addmsg /kinetics/cAMP /kinetics/PKA/cAMP-bind-site-B2 SUBSTRATE n addmsg /kinetics/PKA/R2C2-cAMP2 /kinetics/PKA/cAMP-bind-site-B2 PRODUCT n addmsg /kinetics/PKA/R2C2-cAMP2 /kinetics/PKA/cAMP-bind-site-A1 SUBSTRATE n addmsg /kinetics/cAMP /kinetics/PKA/cAMP-bind-site-A1 SUBSTRATE n addmsg /kinetics/PKA/R2C2-cAMP3 /kinetics/PKA/cAMP-bind-site-A1 PRODUCT n addmsg /kinetics/cAMP /kinetics/PKA/cAMP-bind-site-A2 SUBSTRATE n addmsg /kinetics/PKA/R2C2-cAMP3 /kinetics/PKA/cAMP-bind-site-A2 SUBSTRATE n addmsg /kinetics/PKA/R2C2-cAMP4 /kinetics/PKA/cAMP-bind-site-A2 PRODUCT n addmsg /kinetics/PKA/cAMP-bind-site-B2 /kinetics/PKA/R2C2-cAMP2 REAC B A addmsg /kinetics/PKA/cAMP-bind-site-A1 /kinetics/PKA/R2C2-cAMP2 REAC A B addmsg /kinetics/PKA/cAMP-bind-site-A1 /kinetics/PKA/R2C2-cAMP3 REAC B A addmsg /kinetics/PKA/cAMP-bind-site-A2 /kinetics/PKA/R2C2-cAMP3 REAC A B addmsg /kinetics/PKA/cAMP-bind-site-A2 /kinetics/PKA/R2C2-cAMP4 REAC B A addmsg /kinetics/PKA/Release-C1 /kinetics/PKA/R2C2-cAMP4 REAC A B addmsg /kinetics/PKA/Release-C1 /kinetics/PKA/R2C-cAMP4 REAC B A addmsg /kinetics/PKA/Release-C2 /kinetics/PKA/R2C-cAMP4 REAC A B addmsg /kinetics/PKA/Release-C2 /kinetics/PKA/R2-cAMP4 REAC B A addmsg /kinetics/PKA/R2C2-cAMP4 /kinetics/PKA/Release-C1 SUBSTRATE n addmsg /kinetics/PKA-active /kinetics/PKA/Release-C1 PRODUCT n addmsg /kinetics/PKA/R2C-cAMP4 /kinetics/PKA/Release-C1 PRODUCT n addmsg /kinetics/PKA/R2C-cAMP4 /kinetics/PKA/Release-C2 SUBSTRATE n addmsg /kinetics/PKA-active /kinetics/PKA/Release-C2 PRODUCT n addmsg /kinetics/PKA/R2-cAMP4 /kinetics/PKA/Release-C2 PRODUCT n addmsg /kinetics/PKA/inhib-PKA /kinetics/PKA/PKA-inhibitor REAC A B addmsg /kinetics/PKA-active /kinetics/PKA/inhib-PKA SUBSTRATE n addmsg /kinetics/PKA/PKA-inhibitor /kinetics/PKA/inhib-PKA SUBSTRATE n addmsg /kinetics/PKA/inhibited-PKA /kinetics/PKA/inhib-PKA PRODUCT n addmsg /kinetics/PKA/inhib-PKA /kinetics/PKA/inhibited-PKA REAC B A addmsg /kinetics/PKA/cAMP-bind-site-B1 /kinetics/cAMP REAC A B addmsg /kinetics/PKA/cAMP-bind-site-B2 /kinetics/cAMP REAC A B addmsg /kinetics/PKA/cAMP-bind-site-A1 /kinetics/cAMP REAC A B addmsg /kinetics/PKA/cAMP-bind-site-A2 /kinetics/cAMP REAC A B addmsg /kinetics/AC/AC2*/kenz /kinetics/cAMP MM_PRD pA addmsg /kinetics/AC/AC2-Gs/kenz /kinetics/cAMP MM_PRD pA addmsg /kinetics/AC/AC1-CaM/kenz /kinetics/cAMP MM_PRD pA addmsg /kinetics/AC/AC1-Gs/kenz /kinetics/cAMP MM_PRD pA addmsg /kinetics/AC/AC2*-Gs/kenz /kinetics/cAMP MM_PRD pA addmsg /kinetics/AC/cAMP-PDE*/PDE* /kinetics/cAMP REAC sA B addmsg /kinetics/AC/cAMP-PDE/PDE /kinetics/cAMP REAC sA B addmsg /kinetics/AC/PDE1/PDE1 /kinetics/cAMP REAC sA B addmsg /kinetics/AC/CaM.PDE1/CaM.PDE1 /kinetics/cAMP REAC sA B addmsg /kinetics/AC/AC2*/kenz /kinetics/AC/ATP REAC sA B addmsg /kinetics/AC/AC2-Gs/kenz /kinetics/AC/ATP REAC sA B addmsg /kinetics/AC/AC1-CaM/kenz /kinetics/AC/ATP REAC sA B addmsg /kinetics/AC/AC1-Gs/kenz /kinetics/AC/ATP REAC sA B addmsg /kinetics/AC/AC2*-Gs/kenz /kinetics/AC/ATP REAC sA B addmsg /kinetics/AC/CaM-bind-AC1 /kinetics/AC/AC1-CaM REAC B A addmsg /kinetics/AC/AC1-CaM /kinetics/AC/AC1-CaM/kenz ENZYME n addmsg /kinetics/AC/ATP /kinetics/AC/AC1-CaM/kenz SUBSTRATE n addmsg /kinetics/AC/CaM-bind-AC1 /kinetics/AC/AC1 REAC A B addmsg /kinetics/AC/Gs-bind-AC1 /kinetics/AC/AC1 REAC A B addmsg /kinetics/CaM-Ca4 /kinetics/AC/CaM-bind-AC1 SUBSTRATE n addmsg /kinetics/AC/AC1-CaM /kinetics/AC/CaM-bind-AC1 PRODUCT n addmsg /kinetics/AC/AC1 /kinetics/AC/CaM-bind-AC1 SUBSTRATE n addmsg /kinetics/PKC-active/phosph-AC2 /kinetics/AC/AC2* MM_PRD pA addmsg /kinetics/AC/dephosph-AC2 /kinetics/AC/AC2* REAC A B addmsg /kinetics/AC/Gs-bind-AC2* /kinetics/AC/AC2* REAC A B addmsg /kinetics/AC/AC2* /kinetics/AC/AC2*/kenz ENZYME n addmsg /kinetics/AC/ATP /kinetics/AC/AC2*/kenz SUBSTRATE n addmsg /kinetics/AC/Gs-bind-AC2 /kinetics/AC/AC2-Gs REAC B A addmsg /kinetics/AC/AC2-Gs /kinetics/AC/AC2-Gs/kenz ENZYME n addmsg /kinetics/AC/ATP /kinetics/AC/AC2-Gs/kenz SUBSTRATE n addmsg /kinetics/AC/Gs-bind-AC2 /kinetics/AC/AC2 REAC A B addmsg /kinetics/PKC-active/phosph-AC2 /kinetics/AC/AC2 REAC sA B addmsg /kinetics/AC/dephosph-AC2 /kinetics/AC/AC2 REAC B A addmsg /kinetics/AC/AC2* /kinetics/AC/dephosph-AC2 SUBSTRATE n addmsg /kinetics/AC/AC2 /kinetics/AC/dephosph-AC2 PRODUCT n addmsg /kinetics/AC/Gs-bind-AC1 /kinetics/AC/AC1-Gs REAC B A addmsg /kinetics/AC/AC1-Gs /kinetics/AC/AC1-Gs/kenz ENZYME n addmsg /kinetics/AC/ATP /kinetics/AC/AC1-Gs/kenz SUBSTRATE n addmsg /kinetics/AC/AC2 /kinetics/AC/Gs-bind-AC2 SUBSTRATE n addmsg /kinetics/AC/AC2-Gs /kinetics/AC/Gs-bind-AC2 PRODUCT n addmsg /kinetics/Gs-alpha /kinetics/AC/Gs-bind-AC2 SUBSTRATE n addmsg /kinetics/Gs-alpha /kinetics/AC/Gs-bind-AC1 SUBSTRATE n addmsg /kinetics/AC/AC1 /kinetics/AC/Gs-bind-AC1 SUBSTRATE n addmsg /kinetics/AC/AC1-Gs /kinetics/AC/Gs-bind-AC1 PRODUCT n addmsg /kinetics/AC/cAMP-PDE*/PDE* /kinetics/AC/AMP MM_PRD pA addmsg /kinetics/AC/cAMP-PDE/PDE /kinetics/AC/AMP MM_PRD pA addmsg /kinetics/AC/CaM.PDE1/CaM.PDE1 /kinetics/AC/AMP MM_PRD pA addmsg /kinetics/AC/PDE1/PDE1 /kinetics/AC/AMP MM_PRD pA addmsg /kinetics/AC/Gs-bind-AC2* /kinetics/AC/AC2*-Gs REAC B A addmsg /kinetics/AC/AC2*-Gs /kinetics/AC/AC2*-Gs/kenz ENZYME n addmsg /kinetics/AC/ATP /kinetics/AC/AC2*-Gs/kenz SUBSTRATE n addmsg /kinetics/Gs-alpha /kinetics/AC/Gs-bind-AC2* SUBSTRATE n addmsg /kinetics/AC/AC2*-Gs /kinetics/AC/Gs-bind-AC2* PRODUCT n addmsg /kinetics/AC/AC2* /kinetics/AC/Gs-bind-AC2* SUBSTRATE n addmsg /kinetics/AC/cAMP-PDE/PDE /kinetics/AC/cAMP-PDE REAC eA B addmsg /kinetics/AC/dephosph-PDE /kinetics/AC/cAMP-PDE REAC B A addmsg /kinetics/PKA-active/phosph-PDE /kinetics/AC/cAMP-PDE REAC sA B addmsg /kinetics/AC/cAMP-PDE /kinetics/AC/cAMP-PDE/PDE ENZYME n addmsg /kinetics/cAMP /kinetics/AC/cAMP-PDE/PDE SUBSTRATE n addmsg /kinetics/AC/cAMP-PDE*/PDE* /kinetics/AC/cAMP-PDE* REAC eA B addmsg /kinetics/AC/dephosph-PDE /kinetics/AC/cAMP-PDE* REAC A B addmsg /kinetics/PKA-active/phosph-PDE /kinetics/AC/cAMP-PDE* MM_PRD pA addmsg /kinetics/AC/cAMP-PDE* /kinetics/AC/cAMP-PDE*/PDE* ENZYME n addmsg /kinetics/cAMP /kinetics/AC/cAMP-PDE*/PDE* SUBSTRATE n addmsg /kinetics/AC/cAMP-PDE* /kinetics/AC/dephosph-PDE SUBSTRATE n addmsg /kinetics/AC/cAMP-PDE /kinetics/AC/dephosph-PDE PRODUCT n addmsg /kinetics/AC/PDE1/PDE1 /kinetics/AC/PDE1 REAC eA B addmsg /kinetics/AC/CaM_bind_PDE1 /kinetics/AC/PDE1 REAC A B addmsg /kinetics/AC/PDE1 /kinetics/AC/PDE1/PDE1 ENZYME n addmsg /kinetics/cAMP /kinetics/AC/PDE1/PDE1 SUBSTRATE n addmsg /kinetics/AC/CaM.PDE1/CaM.PDE1 /kinetics/AC/CaM.PDE1 REAC eA B addmsg /kinetics/AC/CaM_bind_PDE1 /kinetics/AC/CaM.PDE1 REAC B A addmsg /kinetics/AC/CaM.PDE1 /kinetics/AC/CaM.PDE1/CaM.PDE1 ENZYME n addmsg /kinetics/cAMP /kinetics/AC/CaM.PDE1/CaM.PDE1 SUBSTRATE n addmsg /kinetics/AC/PDE1 /kinetics/AC/CaM_bind_PDE1 SUBSTRATE n addmsg /kinetics/AC/CaM.PDE1 /kinetics/AC/CaM_bind_PDE1 PRODUCT n addmsg /kinetics/CaM-Ca4 /kinetics/AC/CaM_bind_PDE1 SUBSTRATE n addmsg /kinetics/AC/Gs-bind-AC2 /kinetics/Gs-alpha REAC A B addmsg /kinetics/AC/Gs-bind-AC1 /kinetics/Gs-alpha REAC A B addmsg /kinetics/AC/Gs-bind-AC2* /kinetics/Gs-alpha REAC A B addmsg /kinetics/PP1-active /kinetics/tot_PP1 SUMTOTAL n nInit addmsg /kinetics/PP1-active/Deph-thr286 /kinetics/tot_PP1 SUMTOTAL nComplex nComplexInit addmsg /kinetics/PP1-active/Deph-thr305 /kinetics/tot_PP1 SUMTOTAL nComplex nComplexInit addmsg /kinetics/PP1-active/Deph-thr286c /kinetics/tot_PP1 SUMTOTAL nComplex nComplexInit addmsg /kinetics/PP1-active/Deph_thr286b /kinetics/tot_PP1 SUMTOTAL nComplex nComplexInit addmsg /kinetics/PP1-active/Deph-thr306 /kinetics/tot_PP1 SUMTOTAL nComplex nComplexInit addmsg /kinetics/CaMKII/tot_CaM_CaMKII /kinetics/tot_CaMKII-active SUMTOTAL n nInit addmsg /kinetics/CaMKII/tot_autonomous_CaMKII /kinetics/tot_CaMKII-active SUMTOTAL n nInit addmsg /kinetics/CaM(Ca)n-CaNAB /kinetics/tot_CaN-active SUMTOTAL n nInit addmsg /kinetics/CaNAB-Ca4 /kinetics/tot_CaN-active SUMTOTAL n nInit addmsg /kinetics/Ca /graphs/conc1/Ca.Co PLOT Co *Ca.Co *red addmsg /kinetics/tot_CaMKII-active /graphs/conc1/tot_CaMKII-active.Co PLOT Co *tot_CaMKII-active.Co *blue addmsg /kinetics/tot_CaN-active /graphs/conc2/tot_CaN-active.Co PLOT Co *tot_CaN-active.Co *red addmsg /kinetics/PKA-active /moregraphs/conc3/PKA-active.Co PLOT Co *PKA-active.Co *yellow addmsg /kinetics/tot_PP1 /moregraphs/conc4/tot_PP1.Co PLOT Co *tot_PP1.Co *blue enddump call /kinetics/tot_PP1/notes LOAD \ " tot_PP1 has inputs from Deph-thr286, PP1-active, Deph-thr305, Deph-thr286c, Deph-thr286b,Deph-thr305. except PP1-active all other inputs are enzyme-substrate complex which is not currently supported by doqcs." \ "But can be accessed from GENESIS file." // End of dump call /edit/draw/tree RESET reset