//genesis // kkit Version 6 dumpfile // Saved on Thu May 7 00:12:34 1998 include kkit {argv 1} FASTDT = 0.0005 SIMDT = 0.0005 CONTROLDT = 1 PLOTDT = 0.001 MAXTIME = 2 kparms //genesis initdump -version 3 -ignoreorphans 1 simobjdump table input output alloced step_mode stepsize simobjdump xtree path script namemode sizescale simobjdump xcoredraw xmin xmax ymin ymax simobjdump xtext editable simobjdump xgraph xmin xmax ymin ymax overlay simobjdump xplot pixflags script fg ysquish do_slope wy simobjdump kpool CoTotal CoInit Co CoRemaining n nInit nTotal nMin vol \ slave_enable keepconc notes xtree_fg_req xtree_textfg_req simobjdump xtab input output alloced step_mode stepsize notes editfunc \ xtree_fg_req xtree_textfg_req plotfield manageclass baselevel last_x last_y \ is_running simobjdump group notes editfunc xtree_fg_req xtree_textfg_req plotfield \ manageclass expanded movealone simobjdump kreac A B kf kb is_active oldmsgmode notes editfunc xtree_fg_req \ xtree_textfg_req plotfield manageclass simobjdump kenz CoComplexInit CoComplex nComplexInit nComplex vol sA pA eA B \ k1 k2 k3 keepconc usecomplex ksum oldmsgmode notes editfunc xtree_fg_req \ xtree_textfg_req plotfield manageclass link_to_manage simobjdump stim output level1 width1 delay1 level2 width2 delay2 baselevel \ trig_time trig_mode previous_input notes editfunc xtree_fg_req \ xtree_textfg_req plotfield manageclass is_running simundump group /kinetics/PKC 0 "" edit_group blue black x group 0 0 simundump kpool /kinetics/PKC/PKC-Ca 0 0.28282 3.7208e-17 3.7208e-17 \ 5.9728e-42 2.2325e-11 2.2325e-11 1.6969e+05 0 6e+05 0 1 "" red black simundump kreac /kinetics/PKC/PKC-act-by-Ca 0 34687 34687 1e-06 0.5 1 0 "" \ edit_reac white blue A group simundump kreac /kinetics/PKC/PKC-act-by-DAG 0 83248 83248 1.3333e-08 8.6348 \ 1 0 "" edit_reac white blue A group simundump kreac /kinetics/PKC/PKC-Ca-to-memb 0 88137 88137 1.2705 3.5026 1 0 \ "" edit_reac white blue A group simundump kreac /kinetics/PKC/PKC-DAG-to-memb 0 9641 9641 1 0.1 1 0 "" \ edit_reac white blue A group simundump kreac /kinetics/PKC/PKC-act-by-Ca-AA 0 4162.4 4162.4 2e-09 0.1 1 0 \ "" edit_reac white blue A group simundump kreac /kinetics/PKC/PKC-act-by-DAG-AA 0 46827 46827 2 0.2 1 0 "" \ edit_reac white blue A group simundump kpool /kinetics/PKC/PKC-DAG-AA* 0 0.12061 4.9137e-18 4.9137e-18 0 \ 2.9482e-12 2.9482e-12 72366 0 6e+05 0 1 "" cyan blue simundump kpool /kinetics/PKC/PKC-Ca-AA* 0 0.16962 1.75e-16 1.75e-16 \ 3.5808e-42 1.05e-10 1.05e-10 1.0177e+05 0 6e+05 0 1 "" orange blue simundump kpool /kinetics/PKC/PKC-Ca-memb* 0 0.10258 1.3896e-17 1.3896e-17 \ 2.1663e-42 8.3376e-12 8.3376e-12 61549 0 6e+05 0 1 "" pink blue simundump kpool /kinetics/PKC/PKC-DAG-memb* 0 0.023753 9.4352e-21 9.4352e-21 \ 0 5.6611e-15 5.6611e-15 14252 0 6e+05 0 1 "" yellow blue simundump kpool /kinetics/PKC/PKC-basal* 0 0.0432 0.02 0.02 1.4744e-42 12000 \ 12000 25920 0 6e+05 0 1 "" pink blue simundump kreac /kinetics/PKC/PKC-basal-act 0 57812 57812 1 50 1 0 "" \ edit_reac white blue A group simundump kpool /kinetics/PKC/PKC-AA* 0 1 1.8133e-17 1.8133e-17 3.5513e-41 \ 1.088e-11 1.088e-11 6e+05 0 6e+05 0 1 "" cyan blue simundump kreac /kinetics/PKC/PKC-act-by-AA 0 346.87 346.87 2e-10 0.1 1 0 "" \ edit_reac white blue A group simundump kpool /kinetics/PKC/PKC-Ca-DAG 0 0.0017993 8.4632e-23 8.4632e-23 0 \ 5.0779e-17 5.0779e-17 1079.6 0 6e+05 0 1 "" white blue simundump kreac /kinetics/PKC/PKC-n-DAG 0 5203 5203 1e-09 0.1 1 0 "" \ edit_reac white blue A group simundump kpool /kinetics/PKC/PKC-DAG 0 0.08533 1.161e-16 1.161e-16 0 \ 6.9661e-11 6.9661e-11 51198 0 6e+05 0 1 "" white blue simundump kreac /kinetics/PKC/PKC-n-DAG-AA 0 46827 46827 3e-08 2 1 0 "" \ edit_reac white blue A group simundump kpool /kinetics/PKC/PKC-DAG-AA 0 0.012093 2.5188e-19 2.5188e-19 0 \ 1.5113e-13 1.5113e-13 7255.5 0 6e+05 0 1 "" white blue simundump kpool /kinetics/PKC/PKC-cytosolic 0 1.5489 1 1 5.1888e-41 6e+05 \ 6e+05 9.2935e+05 0 6e+05 0 1 "" white blue simundump kpool /kinetics/DAG 1 1.5 0 0 0 0 0 9e+05 0 6e+05 2 0 "" green \ black simundump kpool /kinetics/Ca 1 0.16 0.08 0.08 1.3231e-59 48000 48000 96000 0 \ 6e+05 2 0 "" red black simundump kpool /kinetics/AA 0 1 0 0 0 0 0 6e+05 0 6e+05 0 1 "" darkgreen \ black simundump kpool /kinetics/PKC-active 1 0.02 0 0.02 1.7868e-51 12000 12000 \ 12000 0 6e+05 2 0 "" red black simundump kenz /kinetics/PKC-active/PKC-act-raf 1 0 0 0 0 6e+05 0 0 0 3238.9 \ 5e-07 16 4 0 0 20 0 "" edit_enz red yellow CoComplex kpool \ enzproto_to_pool_link simundump kenz /kinetics/PKC-active/PKC-inact-GAP 1 0 0 0 0 0 358.95 89.737 \ 448.68 448.68 1e-05 16 4 0 0 20 0 "" edit_enz red yellow CoComplex kpool \ enzproto_to_pool_link simundump kenz /kinetics/PKC-active/PKC-act-GEF 1 0 0 0 0 0 1.775e-09 \ 4.4374e-10 2.2187e-09 2.2187e-09 1e-05 16 4 0 0 20 0 "" edit_enz red yellow \ CoComplex kpool enzproto_to_pool_link simundump kenz /kinetics/PKC-active/PKC-phosph-neurogranin 1 0 0 0 0 6e+05 \ 7578.1 1878.3 9456.5 9456.4 1.7e-07 2.34 0.58 0 0 2.92 0 "" edit_enz red \ red CoComplex kpool enzproto_to_pool_link simundump kenz /kinetics/PKC-active/PKC-phosph-ng-CaM 1 0 0 0 0 6e+05 18492 \ 4622.9 23115 23114 1.02e-07 1.4 0.35 0 0 1.75 0 "" edit_enz red red \ CoComplex kpool enzproto_to_pool_link simundump kenz /kinetics/PKC-active/phosph-AC2 1 0 0 0 0 6e+05 285.25 71.312 \ 356.56 356.56 1e-06 16 4 0 0 20 0 "" edit_enz red red CoComplex kpool \ enzproto_to_pool_link simundump group /kinetics/PLA2 0 "" edit_group darkgreen black x group 0 1 simundump kpool /kinetics/PLA2/PLA2-cytosolic 0 0.4 0.4 0.4 4.9963e-42 \ 2.4e+05 2.4e+05 2.4e+05 0 6e+05 0 1 "" yellow darkgreen simundump kreac /kinetics/PLA2/PLA2-Ca-act 0 498.41 0 1.6667e-06 0.1 1 0 "" \ edit_reac white darkgreen A group simundump kpool /kinetics/PLA2/PLA2-Ca* 0 1 0 0 3.5425e-41 0 0 6e+05 0 6e+05 \ 0 1 "" yellow darkgreen simundump kenz /kinetics/PLA2/PLA2-Ca*/kenz 0 0 0 0 0 6e+05 1.6153e+05 40381 \ 2.0191e+05 2.0185e+05 2.25e-06 21.6 5.4 0 0 27 0 "" edit_enz red yellow \ CoComplex kpool enzproto_to_pool_link simundump kreac /kinetics/PLA2/PIP2-PLA2-act 0 4622.4 4682.4 2e-09 0.5 1 0 "" \ edit_reac white darkgreen A group simundump kpool /kinetics/PLA2/PIP2-PLA2* 0 1 0 0 3.5172e-41 0 0 6e+05 0 \ 6e+05 0 1 "" cyan darkgreen simundump kenz /kinetics/PLA2/PIP2-PLA2*/kenz 0 0 0 0 0 6e+05 6.1234e+05 \ 1.5309e+05 7.6543e+05 7.6546e+05 4.6e-06 44.16 11.04 0 0 55.2 0 "" edit_enz \ red cyan CoComplex kpool enzproto_to_pool_link simundump kreac /kinetics/PLA2/PIP2-Ca-PLA2-act 0 1896.2 1495.2 2e-08 0.1 1 0 \ "" edit_reac white darkgreen A group simundump kpool /kinetics/PLA2/PIP2-Ca-PLA2* 0 1 0 0 3.4595e-41 0 0 6e+05 0 \ 6e+05 0 1 "" cyan darkgreen simundump kenz /kinetics/PLA2/PIP2-Ca-PLA2*/kenz 0 0 0 0 0 6e+05 4.0959e+06 \ 1.024e+06 5.1199e+06 5.1197e+06 1.5e-05 144 36 0 0 180 0 "" edit_enz red \ cyan CoComplex kpool enzproto_to_pool_link simundump kreac /kinetics/PLA2/DAG-Ca-PLA2-act 0 1504.3 1495.2 5e-09 4 1 0 "" \ edit_reac white darkgreen A group simundump kpool /kinetics/PLA2/DAG-Ca-PLA2* 0 1 0 0 3.57e-41 0 0 6e+05 0 \ 6e+05 0 1 "" pink darkgreen simundump kenz /kinetics/PLA2/DAG-Ca-PLA2*/kenz 0 0 0 0 0 6e+05 1.3539e+05 \ 33848 1.6924e+05 1.6923e+05 2.5e-05 240 60 0 0 300 0 "" edit_enz red pink \ CoComplex kpool enzproto_to_pool_link simundump kpool /kinetics/PLA2/APC 0 30 30 30 0 1.8e+07 1.8e+07 1.8e+07 0 \ 6e+05 5 1 "" yellow darkgreen simundump kreac /kinetics/PLA2/Degrade-AA 1 0 1.2585e+06 0.4 0 1 0 "" \ edit_reac white darkgreen A group simundump kpool /kinetics/PLA2/PLA2*-Ca 0 1 0 0 3.5722e-41 0 0 6e+05 0 6e+05 \ 1 1 "" orange darkgreen simundump kenz /kinetics/PLA2/PLA2*-Ca/kenz 0 0 0 0 0 6e+05 0 0 0 0 5e-05 480 \ 120 0 0 600 0 "" edit_enz red orange CoComplex kpool enzproto_to_pool_link simundump kpool /kinetics/PLA2/PLA2* 1 1.6667e-06 0 0 5.9537e-47 0 0 1 0 \ 6e+05 0 0 "" orange darkgreen simundump kreac /kinetics/PLA2/PLA2*-Ca-act 1 0 0 1e-05 0.1 1 0 "" edit_reac \ white darkgreen A group simundump kreac /kinetics/PLA2/dephosphorylate-PLA2* 1 0 0 0.17 0 1 0 "" \ edit_reac white darkgreen A group simundump kpool /kinetics/MAPK* 0 0.36 0 0 9.9228e-65 0 0 2.16e+05 0 6e+05 0 \ 1 "" orange yellow simundump kenz /kinetics/MAPK*/MAPK* 0 0 0 0 0 6e+05 0 0 0 0 6.5e-06 80 20 0 \ 0 100 0 "" edit_enz red orange CoComplex kpool enzproto_to_pool_link simundump kenz /kinetics/MAPK*/MAPK*-feedback 1 0 0 0 0 6e+05 0 0 0 0 \ 3.25e-06 40 10 0 0 50 0 "" edit_enz red orange CoComplex kpool \ enzproto_to_pool_link simundump kpool /kinetics/temp-PIP2 1 25 2.5 2.5 0 1.5e+06 1.5e+06 1.5e+07 0 \ 6e+05 6 1 "" green black simundump kpool /kinetics/IP3 1 1.71 0 0 0 0 0 1.026e+06 0 6e+05 0 0 "" pink \ black simundump kpool /kinetics/Glu 1 1000 0 0 4.6297e-15 0 0 6e+08 0 6e+05 0 1 "" \ green black simundump group /kinetics/PLCbeta 1 "" edit_group maroon black x group 0 0 simundump kreac /kinetics/PLCbeta/Act-PLC-Ca 1 1.4927e+05 1.4926e+05 5e-06 1 \ 1 0 "" edit_reac white maroon A group simundump kpool /kinetics/PLCbeta/PLC 1 0.8 0.8 0.8 2.828e-41 4.8e+05 4.8e+05 \ 4.8e+05 0 6e+05 0 1 "" cyan maroon simundump kreac /kinetics/PLCbeta/Degrade-IP3 1 0 5.0884e+06 1 0 1 0 "" \ edit_reac white maroon A group simundump kpool /kinetics/PLCbeta/Inositol 1 0 0 0 0 0 0 0 0 6e+05 5 0 "" \ green maroon simundump kreac /kinetics/PLCbeta/Degrade-DAG 1 0 5.0113e+06 0.02 0 1 0 "" \ edit_reac white maroon A group simundump kpool /kinetics/PLCbeta/PC 1 1 0 0 0 0 0 1 0 1 4 0 "" green maroon simundump kpool /kinetics/PLCbeta/PLC-Ca 1 0.061192 0 0 0 0 0 36715 0 6e+05 0 \ 0 "" cyan maroon simundump kenz /kinetics/PLCbeta/PLC-Ca/PLC-Ca 1 0 0 0 0 6e+05 7.5231e+05 \ 1.8808e+05 9.4039e+05 9.4039e+05 4.2e-06 40 10 0 0 50 0 "" edit_enz red \ cyan CoComplex kpool enzproto_to_pool_link simundump kreac /kinetics/PLCbeta/Act-PLC-by-Gq 1 2.0418e+05 2.0689e+05 \ 4.2e-05 1 1 0 "" edit_reac white maroon A group simundump kreac /kinetics/PLCbeta/Inact-PLC-Gq 1 0 2715.6 0.0133 0 1 0 "" \ edit_reac white maroon A group simundump kpool /kinetics/PLCbeta/PLC-Ca-Gq 0 0.008698 0 0 0 0 0 5218.8 0 \ 6e+05 0 0 "" cyan maroon simundump kenz /kinetics/PLCbeta/PLC-Ca-Gq/PLCb-Ca-Gq 0 0 0 0 0 6e+05 \ 1.9601e+07 4.9003e+06 2.4501e+07 2.4501e+07 8e-05 192 48 0 0 240 0 "" \ edit_enz red cyan CoComplex kpool enzproto_to_pool_link simundump kpool /kinetics/PLCbeta/PLC-Gq 1 0.063588 0 0 2.2308e-42 0 0 38153 \ 0 6e+05 0 1 "" cyan maroon simundump kreac /kinetics/PLCbeta/PLC-bind-Gq 1 680.63 689.58 4.2e-06 1 1 0 \ "" edit_reac white maroon A group simundump kreac /kinetics/PLCbeta/PLC-Gq-bind-Ca 1 2.0418e+05 2.0419e+05 \ 5e-05 1 1 0 "" edit_reac white maroon A group simundump kpool /kinetics/PIP2 1 5 2.5 2.5 0 1.5e+06 1.5e+06 3e+06 0 6e+05 6 \ 1 "" green black simundump kpool /kinetics/BetaGamma 1 1.6 0 0 2.5782e-58 0 0 9.6e+05 0 6e+05 \ 0 0 "" yellow black simundump kpool /kinetics/G*GTP 1 5 0 0 1.7647e-40 0 0 3e+06 0 6e+05 2 0 "" \ red black simundump kpool /kinetics/G*GDP 1 0.1667 0 0 0 0 0 1.0002e+05 0 6e+05 0 0 "" \ yellow black simundump group /kinetics/Gq 1 "" edit_group blue black x group 0 0 simundump kreac /kinetics/Gq/RecLigandBinding 1 0 0 2.8e-05 10 1 0 "" \ edit_reac white blue A group simundump kpool /kinetics/Gq/G-GDP 1 1.6 1 1 2.5187e-41 6e+05 6e+05 9.6e+05 0 \ 6e+05 0 0 "" yellow blue simundump kreac /kinetics/Gq/Basal-Act-G 1 0 53.698 1e-04 0 1 0 "" edit_reac \ white blue A group simundump kreac /kinetics/Gq/Trimerize-G 1 0 53.707 1e-05 0 1 0 "" edit_reac \ white blue A group simundump kreac /kinetics/Gq/Inact-G 1 0 438.9 0.0133 0 1 0 "" edit_reac \ white blue A group simundump kpool /kinetics/Gq/mGluR 1 0.3 0.3 0.3 3.7438e-42 1.8e+05 1.8e+05 \ 1.8e+05 0 6e+05 0 0 "" green blue simundump kpool /kinetics/Gq/Rec-Glu 1 0.8 0 0 2.8578e-41 0 0 4.8e+05 0 6e+05 \ 0 0 "" green blue simundump kpool /kinetics/Gq/Rec-Gq 1 1.6667e-06 0 0 0 0 0 1 0 6e+05 0 0 "" \ green blue simundump kreac /kinetics/Gq/Rec-Glu-bind-Gq 1 0 0 1e-08 1e-04 1 0 "" \ edit_reac white blue A group simundump kreac /kinetics/Gq/Glu-bind-Rec-Gq 1 0 0 2.8e-05 0.1 1 0 "" \ edit_reac white blue A group simundump kpool /kinetics/Gq/Rec-Glu-Gq 1 1.6667e-06 0 0 5.9537e-47 0 0 1 0 \ 6e+05 0 0 "" orange blue simundump kreac /kinetics/Gq/Activate-Gq 1 0 0 0.01 0 1 0 "" edit_reac white \ blue A group simundump kreac /kinetics/Gq/Rec-bind-Gq 1 62887 62887 1e-06 1 1 0 "" \ edit_reac white blue A group simundump kpool /kinetics/Gq/mGluRAntag 1 100 0 0 0 0 0 6e+07 0 6e+05 4 1 "" \ seagreen blue simundump kreac /kinetics/Gq/Antag-bind-Rec-Gq 1 0 0 1e-04 0.01 1 0 "" \ edit_reac white blue A group simundump kpool /kinetics/Gq/Blocked-rec-Gq 1 1.6667e-06 0 0 5.9537e-47 0 0 1 \ 0 6e+05 0 0 "" seagreen blue simundump group /kinetics/MAPK 0 "" edit_group brown black x group 0 0 simundump kpool /kinetics/MAPK/craf-1 0 0.2 0.2 0.2 1.2399e-74 1.2e+05 \ 1.2e+05 1.2e+05 0 6e+05 0 1 "" pink brown simundump kpool /kinetics/MAPK/craf-1* 0 0.2 0 0 9.1883e-71 0 0 1.2e+05 0 \ 6e+05 0 1 "" pink brown simundump kpool /kinetics/MAPK/MAPKK 0 0.18 0.18 0.18 0 1.08e+05 1.08e+05 \ 1.08e+05 0 6e+05 0 1 "" pink brown simundump kpool /kinetics/MAPK/MAPK 0 0.36 0.36 0.36 0 2.16e+05 2.16e+05 \ 2.16e+05 0 6e+05 0 1 "" pink brown simundump kpool /kinetics/MAPK/craf-1** 1 0.2 0 0 9.1883e-71 0 0 1.2e+05 0 \ 6e+05 0 0 "" hotpink brown simundump kpool /kinetics/MAPK/MAPK-tyr 1 0.36 0 0 1.6538e-70 0 0 2.16e+05 0 \ 6e+05 0 0 "" orange brown simundump kpool /kinetics/MAPK/MAPKK* 0 0.18 0 0 8.2695e-71 0 0 1.08e+05 0 \ 6e+05 0 1 "" pink brown simundump kenz /kinetics/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 6e+05 0 0 0 0 2.7e-05 \ 0.6 0.15 0 0 0.75 0 "" edit_enz red pink CoComplex kpool \ enzproto_to_pool_link simundump kenz /kinetics/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 6e+05 0 0 0 0 2.7e-05 \ 0.6 0.15 0 0 0.75 0 "" edit_enz red pink CoComplex kpool \ enzproto_to_pool_link simundump kpool /kinetics/MAPK/MAPKK-ser 1 0.18 0 0 8.2695e-71 0 0 1.08e+05 0 \ 6e+05 0 0 "" pink brown simundump kpool /kinetics/MAPK/Raf-GTP-Ras* 1 0.0104 0 0 4.7772e-72 0 0 6240 \ 0 6e+05 0 0 "" red brown simundump kenz /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.1 1 0 0 0 0 0 0 0 0 0 \ 5.5e-06 0.42 0.105 0 0 0.525 0 "" edit_enz red red CoComplex kpool \ enzproto_to_pool_link simundump kenz /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.2 1 0 0 0 0 0 0 0 0 0 \ 5.5e-06 0.42 0.105 0 0 0.525 0 "" edit_enz red red CoComplex kpool \ enzproto_to_pool_link simundump kpool /kinetics/MKP-1 1 0.008 0.0032 0.0032 1.516e-71 1920 1920 \ 4800 0 6e+05 0 1 "" hotpink black simundump kenz /kinetics/MKP-1/MKP1-tyr-deph 1 0 0 0 0 6e+05 0 0 0 0 0.000125 \ 4 1 0 0 5 0 "" edit_enz red hotpink CoComplex kpool enzproto_to_pool_link simundump kenz /kinetics/MKP-1/MKP1-thr-deph 1 0 0 0 0 6e+05 0 0 0 0 0.000125 \ 4 1 0 0 5 0 "" edit_enz red hotpink CoComplex kpool enzproto_to_pool_link simundump kreac /kinetics/Ras-act-craf 1 0 0 4e-05 0.5 0 0 "" edit_reac white \ black A group simundump kpool /kinetics/PPhosphatase2A 1 0.224 0.224 0.224 0 1.344e+05 \ 1.344e+05 1.344e+05 0 6e+05 0 0 "" hotpink yellow simundump kenz /kinetics/PPhosphatase2A/craf-deph 1 0 0 0 0 6e+05 0 0 0 0 \ 3.3e-06 25 6 0 0 31 0 "" edit_enz red hotpink CoComplex kpool \ enzproto_to_pool_link simundump kenz /kinetics/PPhosphatase2A/MAPKK-deph 1 0 0 0 0 6e+05 0 0 0 0 \ 3.3e-06 25 6 0 0 31 0 "" edit_enz red hotpink CoComplex kpool \ enzproto_to_pool_link simundump kenz /kinetics/PPhosphatase2A/MAPKK-deph-ser 1 0 0 0 0 6e+05 0 0 0 \ 0 3.3e-06 25 6 0 0 31 0 "" edit_enz red hotpink CoComplex kpool \ enzproto_to_pool_link simundump kenz /kinetics/PPhosphatase2A/craf**-deph 1 0 0 0 0 0 0 0 0 0 \ 3.3e-06 25 6 0 0 31 0 "" edit_enz red hotpink CoComplex kpool \ enzproto_to_pool_link simundump group /kinetics/Ras 1 "" edit_group blue black x group 0 0 simundump kreac /kinetics/Ras/bg-act-GEF 1 3.4255e-10 3.4256e-10 1e-05 1 1 0 \ "" edit_reac white blue A group simundump kpool /kinetics/Ras/GEF-Gprot-bg 1 0.1 0 0 2.7563e-65 0 0 60000 0 \ 6e+05 0 1 "" hotpink blue simundump kenz /kinetics/Ras/GEF-Gprot-bg/GEF-bg_act-ras 1 0 0 0 0 6e+05 \ 1.0852e-11 2.713e-12 1.3565e-11 1.3565e-11 3.3e-07 0.08 0.02 0 0 0.1 0 "" \ edit_enz red hotpink CoComplex kpool enzproto_to_pool_link simundump kreac /kinetics/Ras/dephosph-GEF 1 0 4.4372e-10 1 0 1 0 "" \ edit_reac white blue A group simundump kpool /kinetics/Ras/inact-GEF 1 0.1 0.1 0.1 2.7563e-65 60000 60000 \ 60000 0 6e+05 0 1 "" hotpink blue simundump kpool /kinetics/Ras/GEF* 1 0.1 0 0 2.7563e-65 0 0 60000 0 6e+05 0 0 \ "" hotpink blue simundump kenz /kinetics/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 6e+05 1.4053e-11 \ 3.5132e-12 1.7566e-11 1.7571e-11 3.3e-07 0.08 0.02 0 0 0.1 0 "" edit_enz \ red hotpink CoComplex kpool enzproto_to_pool_link simundump kpool /kinetics/Ras/GTP-Ras 1 0.2 0 0 5.513e-65 0 0 1.2e+05 0 6e+05 \ 0 0 "" orange blue simundump kpool /kinetics/Ras/GDP-Ras 1 0.2 0.2 0.2 6.6237e-72 1.2e+05 \ 1.2e+05 1.2e+05 0 6e+05 0 1 "" pink blue simundump kreac /kinetics/Ras/Ras-intrinsic-GTPase 1 0 3.0487e-09 1e-04 0 1 0 \ "" edit_reac white blue A group simundump kreac /kinetics/Ras/dephosph-GAP 1 0 89.73 0.1 0 1 0 "" edit_reac \ white blue A group simundump kpool /kinetics/Ras/GAP* 1 0.05 0 0 1.3369e-65 0 0 30000 0 6e+05 0 \ 1 "" red blue simundump kpool /kinetics/Ras/GAP 1 0.002 0.002 0.002 4.222e-67 1200 1200 \ 1200 0 6e+05 0 1 "" red blue simundump kenz /kinetics/Ras/GAP/GAP-inact-ras 1 0 0 0 0 6e+05 1.413e-05 \ 1.413e-07 1.4271e-05 1.4271e-05 0.001666 1000 10 0 0 1010 0 "" edit_enz red \ red CoComplex kpool enzproto_to_pool_link simundump kpool /kinetics/Ras/inact-GEF* 1 1.6667e-06 0 0 0 0 0 1 0 6e+05 0 0 \ "" hotpink blue simundump kreac /kinetics/Ras/CaM-bind-GEF 1 9.9888e-11 1.1379e-12 1e-04 1 1 \ 0 "" edit_reac white blue A group simundump kpool /kinetics/Ras/CaM-GEF 1 1.6667e-06 0 0 4.5938e-70 0 0 1 0 \ 6e+05 0 0 "" pink blue simundump kenz /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 0 0 6e+05 \ 3.1532e-12 7.8831e-13 3.9415e-12 3.9556e-12 3.3e-07 0.08 0.02 0 0 0.1 0 "" \ edit_enz red pink CoComplex kpool enzproto_to_pool_link simundump kreac /kinetics/Ras/dephosph-inact-GEF* 1 0 0 1 0 1 0 "" edit_reac \ white blue A group simundump kpool /kinetics/PKA-active 1 1.6667e-06 0 0 9.9228e-53 0 0 1 0 \ 6e+05 0 0 "" yellow black simundump kenz /kinetics/PKA-active/PKA-phosph-GEF 1 0 0 0 0 6e+05 3.9349e-10 \ 9.8372e-11 4.9186e-10 4.9186e-10 1e-05 36 9 0 0 45 0 "" edit_enz red yellow \ CoComplex kpool enzproto_to_pool_link simundump kenz /kinetics/PKA-active/PKA-phosph-I1 1 0 0 0 0 6e+05 1.5774e+05 \ 39436 1.9718e+05 1.9718e+05 1e-05 36 9 0 0 45 0 "" edit_enz red yellow \ CoComplex kpool enzproto_to_pool_link simundump kenz /kinetics/PKA-active/PKA-phosph-GAP 1 0 0 0 0 6e+05 1103.3 \ 275.82 1379.1 1379.1 9e-05 108 27 0 0 135 0 "" edit_enz red yellow \ CoComplex kpool enzproto_to_pool_link simundump kenz /kinetics/PKA-active/phosph-PDE 1 0 0 0 0 6e+05 0 0 0 0 1e-05 \ 36 9 0 0 45 0 "" edit_enz red yellow CoComplex kpool enzproto_to_pool_link simundump kpool /kinetics/CaM-Ca4 1 5 0 0 2.977e-46 0 0 3e+06 0 6e+05 0 0 "" \ blue yellow simundump group /kinetics/CaMKII 1 "" edit_group purple black x group 0 0 simundump kpool /kinetics/CaMKII/CaMKII 1 135 70 70 6.2022e-68 4.2e+07 \ 4.2e+07 8.1e+07 0 6e+05 0 0 "" palegreen purple simundump kpool /kinetics/CaMKII/CaMKII-CaM 1 0 0 0 0 0 0 0 0 6e+05 0 0 "" \ palegreen purple simundump kpool /kinetics/CaMKII/CaMKII-thr286*-CaM 1 1.6667e-06 0 0 0 0 0 1 \ 0 6e+05 0 0 "" palegreen purple simundump kpool /kinetics/CaMKII/CaMKII*** 1 1.6667e-06 0 0 0 0 0 1 0 6e+05 0 \ 0 "" cyan purple simundump kreac /kinetics/CaMKII/CaMKII-bind-CaM 1 0.013286 0.013389 \ 8.3333e-05 5 1 0 "" edit_reac white purple A group simundump kreac /kinetics/CaMKII/CaMK-thr286-bind-CaM 1 47.14 0.18537 \ 0.001667 0.1 1 0 "" edit_reac white purple A group simundump kpool /kinetics/CaMKII/CaMKII-thr286 1 1.6667e-06 0 0 0 0 0 1 0 \ 6e+05 0 0 "" red purple simundump kpool /kinetics/CaMKII/CaMK-thr306 1 1.6667e-06 0 0 0 0 0 1 0 6e+05 \ 0 0 "" palegreen purple simundump kpool /kinetics/CaMKII/total-CaMKII 1 70 70 70 0 4.2e+07 4.2e+07 \ 4.2e+07 0 6e+05 4 0 "" cyan purple simundump kreac /kinetics/CaMKII/basal-activity 1 0 0.10163 0.003 0 1 0 "" \ edit_reac white purple A group simundump kpool /kinetics/CaMKII/tot_CaM_CaMKII 1 0 0 0 0 0 0 0 0 6e+05 0 0 \ "" green purple simundump kenz /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_305 1 0 0 0 0 6e+05 \ 2.7417 0.68542 3.4271 3.4044 18.48 24 6 0 0 30 0 "" edit_enz red green \ CoComplex kpool enzproto_to_pool_link simundump kenz /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_286 1 0 0 0 0 6e+05 \ 2.8039e-05 7.0097e-06 3.5049e-05 3.215e-05 1.54 2 0.5 0 0 2.5 0 "" edit_enz \ red green CoComplex kpool enzproto_to_pool_link simundump kpool /kinetics/CaMKII/tot_autonomous_CaMKII 1 0 0 0 0 0 0 0 0 \ 6e+05 0 0 "" green purple simundump kenz /kinetics/CaMKII/tot_autonomous_CaMKII/auton_305 1 0 0 0 0 \ 6e+05 198.04 49.509 247.55 246.74 12 24 6 0 0 30 0 "" edit_enz red green \ CoComplex kpool enzproto_to_pool_link simundump kenz /kinetics/CaMKII/tot_autonomous_CaMKII/auton_286 1 0 0 0 0 \ 6e+05 0.0019468 0.0004867 0.0024335 0.0023301 1 2 0.5 0 0 2.5 0 "" edit_enz \ red green CoComplex kpool enzproto_to_pool_link simundump kpool /kinetics/PP1-active 1 1.8 1.8 1.8 2.838e-58 1.08e+06 \ 1.08e+06 1.08e+06 0 6e+05 0 0 "" cyan yellow simundump kenz /kinetics/PP1-active/Deph-thr286 1 0 0 0 0 6e+05 2.3156 0.5789 \ 2.8945 2.8944 5.72e-07 1.4 0.35 0 0 1.75 0 "" edit_enz red cyan CoComplex \ kpool enzproto_to_pool_link simundump kenz /kinetics/PP1-active/Deph-thr305 1 0 0 0 0 6e+05 2.4115e+05 \ 60288 3.0144e+05 3.0143e+05 5.72e-07 1.4 0.35 0 0 1.75 0 "" edit_enz red \ cyan CoComplex kpool enzproto_to_pool_link simundump kenz /kinetics/PP1-active/Deph-thr306 1 0 0 0 0 6e+05 473.62 118.41 \ 592.03 591.97 5.72e-07 1.4 0.35 0 0 1.75 0 "" edit_enz red cyan CoComplex \ kpool enzproto_to_pool_link simundump kenz /kinetics/PP1-active/Deph-thr286c 1 0 0 0 0 6e+05 2.4115e+05 \ 60288 3.0144e+05 3.0143e+05 5.72e-07 1.4 0.35 0 0 1.75 0 "" edit_enz red \ cyan CoComplex kpool enzproto_to_pool_link simundump kenz /kinetics/PP1-active/Deph_thr286b 1 0 0 0 0 6e+05 17.844 \ 4.4611 22.305 22.305 5.72e-07 1.4 0.35 0 0 1.75 0 "" edit_enz red cyan \ CoComplex kpool enzproto_to_pool_link simundump group /kinetics/CaM 1 "" edit_group blue black x group 0 0 simundump kpool /kinetics/CaM/CaM 1 25 20 20 1.1316e-51 1.2e+07 1.2e+07 \ 1.5e+07 0 6e+05 0 0 "" pink blue simundump kreac /kinetics/CaM/CaM-TR2-bind-Ca 1 3.759e+06 3.759e+06 2e-10 72 \ 1 0 "" edit_reac white blue A group simundump kreac /kinetics/CaM/CaM-TR2-Ca2-bind-Ca 1 15036 15036 6e-06 10 1 0 \ "" edit_reac white blue A group simundump kreac /kinetics/CaM/CaM-Ca3-bind-Ca 1 55.934 55.934 7.75e-07 10 1 0 \ "" edit_reac white blue A group simundump kpool /kinetics/CaM/neurogranin-CaM 1 1.6667e-06 0 0 0 0 0 1 0 \ 6e+05 0 0 "" red blue simundump kreac /kinetics/CaM/neurogranin-bind-CaM 1 3.7769e+06 3.7815e+06 \ 5e-07 1 1 0 "" edit_reac white blue A group simundump kpool /kinetics/CaM/neurogranin* 1 1.6667e-06 0 0 0 0 0 1 0 6e+05 0 \ 0 "" red blue simundump kpool /kinetics/CaM/neurogranin 1 10 10 10 8.3897e-52 6e+06 6e+06 \ 6e+06 0 6e+05 0 0 "" red blue simundump kreac /kinetics/CaM/dephosph-neurogranin 1 0 6448.5 0.005 0 1 0 "" \ edit_reac white blue A group simundump kpool /kinetics/CaM-Ca3 1 1.6667e-06 0 0 0 0 0 1 0 6e+05 0 0 "" \ hotpink yellow simundump kpool /kinetics/CaM-TR2-Ca2 1 1.6667e-06 0 0 0 0 0 1 0 6e+05 0 0 "" \ pink yellow simundump kpool /kinetics/CaM(Ca)n-CaNAB 1 0 0 0 0 0 0 0 0 6e+05 0 1 "" \ darkblue yellow simundump kenz /kinetics/CaM(Ca)n-CaNAB/dephosph_neurogranin 1 0 0 0 0 6e+05 \ 0 0 0 0 5.56e-07 2.67 0.67 0 0 3.34 0 "" edit_enz red darkblue CoComplex \ kpool enzproto_to_pool_link simundump kenz /kinetics/CaM(Ca)n-CaNAB/dephosph_inhib1 1 0 0 0 0 6e+05 \ 0.55792 0.13948 0.6974 0.69741 5.7e-07 1.36 0.34 0 0 1.7 0 "" edit_enz red \ darkblue CoComplex kpool enzproto_to_pool_link simundump kenz /kinetics/CaM(Ca)n-CaNAB/dephosph-PP1-I* 1 0 0 0 0 6e+05 \ 127.31 31.828 159.14 159.14 5.7e-07 1.36 0.34 0 0 1.7 0 "" edit_enz white \ darkblue CoComplex kpool enzproto_to_pool_link simundump group /kinetics/PP1 1 "" edit_group yellow black x group 0 0 simundump kpool /kinetics/PP1/I1 1 1.8 1.8 1.8 2.3978e-64 1.08e+06 1.08e+06 \ 1.08e+06 0 6e+05 0 1 "" orange yellow simundump kpool /kinetics/PP1/I1* 1 0.1 0.001 0.001 2.6617e-65 600 600 60000 \ 0 6e+05 0 0 "" orange yellow simundump kreac /kinetics/PP1/Inact-PP1 1 47007 86270 0.0008333 0.1 1 0 "" \ edit_reac white yellow A group simundump kpool /kinetics/PP1/PP1-I1* 1 1.6667e-06 0 0 0 0 0 1 0 6e+05 0 0 "" \ brown yellow simundump kpool /kinetics/PP1/PP1-I1 1 1.6667e-06 0 0 0 0 0 1 0 6e+05 0 0 "" \ brown yellow simundump kreac /kinetics/PP1/dissoc-PP1-I1 1 0 39264 1 0 1 0 "" edit_reac \ white yellow A group simundump kpool /kinetics/PP2A 1 0.17 0.12 0.12 1.6843e-65 72000 72000 \ 1.02e+05 0 6e+05 0 0 "" red black simundump kenz /kinetics/PP2A/PP2A-dephosph-I1 1 0 0 0 0 6e+05 716.37 171.93 \ 888.3 888.31 6.6e-06 25 6 0 0 31 0 "" edit_enz red red CoComplex kpool \ enzproto_to_pool_link simundump kenz /kinetics/PP2A/PP2A-dephosph-PP1-I* 1 0 0 0 0 6e+05 1.6347e+05 \ 39232 2.027e+05 2.027e+05 6.6e-06 25 6 0 0 31 0 "" edit_enz red red \ CoComplex kpool enzproto_to_pool_link simundump kpool /kinetics/CaNAB-Ca4 1 1.6667e-06 0 0 0 0 0 1 0 6e+05 0 1 "" \ tan yellow simundump kenz /kinetics/CaNAB-Ca4/dephosph_inhib1_noCaM 1 0 0 0 0 6e+05 \ 1.1898 0.29746 1.4873 1.4875 5.7e-08 0.136 0.034 0 0 0.17 0 "" edit_enz red \ tan CoComplex kpool enzproto_to_pool_link simundump group /kinetics/PP2B 1 "" edit_group red3 black x group 0 0 simundump kpool /kinetics/PP2B/CaNAB 1 25 1 1 1.1478e-68 6e+05 6e+05 1.5e+07 \ 0 6e+05 0 1 "" tan red3 simundump kpool /kinetics/PP2B/CaNAB-Ca2 1 1.6667e-06 0 0 0 0 0 1 0 6e+05 0 0 \ "" tan red3 simundump kreac /kinetics/PP2B/Ca-bind-CaNAB-Ca2 1 12668 12668 1e-11 1 1 0 "" \ edit_reac white red3 A group simundump kreac /kinetics/PP2B/Ca-bind-CaNAB 1 5.4983e+05 5.4983e+05 2.78e-08 \ 1 1 0 "" edit_reac white red3 A group simundump kreac /kinetics/PP2B/CaM-Ca2-bind-CaNAB 1 386.46 386.46 4e-07 1 1 0 \ "" edit_reac white red3 A group simundump kpool /kinetics/PP2B/CaMCa3-CaNAB 1 1.6667e-06 0 0 0 0 0 1 0 6e+05 \ 0 0 "" blue red3 simundump kpool /kinetics/PP2B/CaMCa2-CANAB 1 1.6667e-06 0 0 0 0 0 1 0 6e+05 \ 0 0 "" blue red3 simundump kpool /kinetics/PP2B/CaMCa4-CaNAB 1 1.6667e-06 0 0 0 0 0 1 0 6e+05 \ 0 0 "" blue red3 simundump kreac /kinetics/PP2B/CaMCa3-bind-CaNAB 1 103.79 103.79 3.73e-06 1 1 \ 0 "" edit_reac white red3 A group simundump kreac /kinetics/PP2B/CaMCa4-bind-CaNAB 1 103.69 103.69 0.001 1 1 0 \ "" edit_reac white red3 A group simundump group /kinetics/PKA 0 "" edit_group blue blue x group 0 0 simundump kpool /kinetics/PKA/R2C2 0 0.5 0.5 0.5 4.8728e-65 3e+05 3e+05 3e+05 \ 0 6e+05 0 1 "" white blue simundump kpool /kinetics/PKA/R2C2-cAMP 0 1 0 0 2.6485e-64 0 0 6e+05 0 6e+05 \ 0 1 "" white blue simundump kreac /kinetics/PKA/cAMP-bind-site-B1 0 7.7373e+05 7.7373e+05 9e-05 \ 33 1 0 "" edit_reac white blue A group simundump kreac /kinetics/PKA/cAMP-bind-site-B2 1 93546 93546 9e-05 33 1 0 "" \ edit_reac white blue A group simundump kreac /kinetics/PKA/cAMP-bind-site-A1 1 15708 15708 0.000125 110 1 \ 0 "" edit_reac white blue A group simundump kreac /kinetics/PKA/cAMP-bind-site-A2 1 791.35 791.33 0.000125 32.5 \ 1 0 "" edit_reac white blue A group simundump kpool /kinetics/PKA/R2C2-cAMP2 1 1.6667e-06 0 0 0 0 0 1 0 6e+05 0 0 \ "" white blue simundump kpool /kinetics/PKA/R2C2-cAMP3 1 1.6667e-06 0 0 0 0 0 1 0 6e+05 0 0 \ "" white blue simundump kpool /kinetics/PKA/R2C2-cAMP4 1 1.6667e-06 0 0 0 0 0 1 0 6e+05 0 0 \ "" white blue simundump kpool /kinetics/PKA/R2C-cAMP4 1 1.6667e-06 0 0 0 0 0 1 0 6e+05 0 0 \ "" white blue simundump kpool /kinetics/PKA/R2-cAMP4 1 0.15 0 0 5.5075e-66 0 0 90000 0 \ 6e+05 0 0 "" white blue simundump kreac /kinetics/PKA/Release-C1 1 1461 1460.9 60 3e-05 1 0 "" \ edit_reac white blue A group simundump kreac /kinetics/PKA/Release-C2 1 82694 82694 60 3e-05 1 0 "" \ edit_reac white blue A group simundump kpool /kinetics/PKA/PKA-inhibitor 1 1 0.25 0.25 2.6043e-64 1.5e+05 \ 1.5e+05 6e+05 0 6e+05 0 1 "" cyan blue simundump kreac /kinetics/PKA/inhib-PKA 1 1.1691e+05 1.1691e+05 1e-04 1 1 0 \ "" edit_reac white blue A group simundump kpool /kinetics/PKA/inhibited-PKA 1 1.6667e-06 0 0 0 0 0 1 0 6e+05 \ 0 0 "" cyan blue simundump kpool /kinetics/cAMP 1 10 0 0 6.1228e-52 0 0 6e+06 0 6e+05 2 0 "" \ green black simundump group /kinetics/AC 1 "" edit_group blue blue x group 0 0 simundump kpool /kinetics/AC/ATP 1 5000 5000 5000 0 3e+09 3e+09 3e+09 0 6e+05 \ 4 0 "" red blue simundump kpool /kinetics/AC/AC1-CaM 1 1.6667e-06 0 0 1.6538e-58 0 0 1 0 \ 6e+05 0 0 "" orange blue simundump kenz /kinetics/AC/AC1-CaM/kenz 1 0 0 0 0 6e+05 0 0 9.5017e+05 0 \ 7.5e-06 72 18 0 1 90 0 "" edit_enz red orange CoComplex kpool \ enzproto_to_pool_link simundump kpool /kinetics/AC/AC1 1 1 0.02 0.02 9.8347e-53 12000 12000 6e+05 0 \ 6e+05 0 1 "" orange blue simundump kreac /kinetics/AC/CaM-bind-AC1 1 0 0 8.3333e-05 1 1 0 "" edit_reac \ white blue A group simundump kpool /kinetics/AC/AC2* 1 0.010851 0 0 9.595e-55 0 0 6510.3 0 6e+05 \ 0 0 "" yellow blue simundump kenz /kinetics/AC/AC2*/kenz 1 0 0 0 0 6e+05 19840 4960 0 0.40901 \ 2.9e-06 28 7 0 1 35 0 "" edit_enz red yellow CoComplex kpool \ enzproto_to_pool_link simundump kpool /kinetics/AC/AC2-Gs 1 1.6667e-06 0 0 0 0 0 1 0 6e+05 0 0 "" \ yellow blue simundump kenz /kinetics/AC/AC2-Gs/kenz 1 0 0 0 0 6e+05 1.4265e+05 35663 \ 7.1263e+05 0 7.5e-06 72 18 0 1 90 0 "" edit_enz red yellow CoComplex kpool \ enzproto_to_pool_link simundump kpool /kinetics/AC/AC2 1 0.015 0.015 0.015 1.423e-54 9000 9000 9000 \ 0 6e+05 0 1 "" yellow blue simundump kreac /kinetics/AC/dephosph-AC2 1 0 70.857 0.1 0 1 0 "" edit_reac \ white blue A group simundump kpool /kinetics/AC/AC1-Gs 1 1.6667e-06 0 0 0 0 0 1 0 6e+05 0 0 "" \ orange blue simundump kenz /kinetics/AC/AC1-Gs/kenz 1 0 0 0 0 0 4.8165e+05 1.2041e+05 0 0 \ 7.5e-06 72 18 0 1 90 0 "" edit_enz red orange CoComplex kpool \ enzproto_to_pool_link simundump kreac /kinetics/AC/Gs-bind-AC2 1 1981.3 1980.9 0.00083333 1 1 0 "" \ edit_reac white blue A group simundump kreac /kinetics/AC/Gs-bind-AC1 1 6689.6 6689.6 0.00021 1 1 0 "" \ edit_reac white blue A group simundump kpool /kinetics/AC/AMP 1 3.2549e+05 3.2549e+05 3.2549e+05 0 \ 3.2549e+05 3.2549e+05 3.2549e+05 0 1 0 0 "" pink blue simundump kpool /kinetics/AC/AC2*-Gs 1 1.6667e-06 0 0 0 0 0 1 0 6e+05 0 0 "" \ green blue simundump kenz /kinetics/AC/AC2*-Gs/kenz 1 0 0 0 0 0 1.2753e+06 3.1881e+05 \ 7.2038e+05 9.1736 7.5e-06 216 54 0 1 270 0 "" edit_enz red green CoComplex \ kpool enzproto_to_pool_link simundump kreac /kinetics/AC/Gs-bind-AC2* 1 5904 5904.4 0.0013888 1 1 0 "" \ edit_reac white blue A group simundump kpool /kinetics/AC/cAMP-PDE 1 1 0.45 0.45 6.1937e-53 2.7e+05 \ 2.7e+05 6e+05 0 6e+05 0 0 "" green blue simundump kenz /kinetics/AC/cAMP-PDE/PDE 1 0 0 0 0 6e+05 1.7408e+06 \ 4.3521e+05 2.176e+06 2.176e+06 4.2e-06 40 10 0 0 50 0 "" edit_enz red green \ CoComplex kpool enzproto_to_pool_link simundump kpool /kinetics/AC/cAMP-PDE* 1 1.6667e-06 0 0 1.6538e-58 0 0 1 0 \ 6e+05 0 0 "" green blue simundump kenz /kinetics/AC/cAMP-PDE*/PDE* 1 0 0 0 0 6e+05 0 0 0 0 8.4e-06 80 \ 20 0 0 100 0 "" edit_enz red green CoComplex kpool enzproto_to_pool_link simundump kreac /kinetics/AC/dephosph-PDE 1 0 0 0.1 0 1 0 "" edit_reac white \ blue A group simundump kpool /kinetics/AC/PDE1 1 2 2 2 0 1.2e+06 1.2e+06 1.2e+06 0 6e+05 0 \ 0 "" green blue simundump kenz /kinetics/AC/PDE1/PDE1 1 0 0 0 0 6e+05 0 0 0 0 3.5e-07 6.67 \ 1.667 0 0 8.337 0 "" edit_enz red green CoComplex kpool \ enzproto_to_pool_link simundump kpool /kinetics/AC/CaM.PDE1 1 1.6667e-06 0 0 0 0 0 1 0 6e+05 0 0 "" \ green blue simundump kenz /kinetics/AC/CaM.PDE1/CaM.PDE1 1 0 0 0 0 6e+05 0 0 0 0 2.1e-06 \ 40 10 0 0 50 0 "" edit_enz red green CoComplex kpool enzproto_to_pool_link simundump kreac /kinetics/AC/CaM_bind_PDE1 1 0 0 0.0012 5 0 0 "" edit_reac \ white blue A group simundump kpool /kinetics/Gs-alpha 1 0.01 0 0 1.2738e-83 0 0 6000 0 6e+05 2 0 \ "" red black simundump xtab /kinetics/Ca_tab 1 0 0 1 2 0 "" edit_xtab white red output \ group 0 0 0 3 loadtab /kinetics/Ca_tab table 1 100 0 100 \ 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 \ 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 \ 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 simundump kreac /kinetics/remove_glu 1 0 0.056712 500 1000 1 0 "" edit_reac \ white black A group simundump stim /kinetics/stim 1 0 100 0.002 0.1 0 0 0 0 -1 0 0 "" edit_stim \ white red output group 3 simundump kpool /kinetics/synapse 1 1.6667e-06 0 0 1.286e-29 0 0 1 0 6e+05 2 \ 0 "" green black simundump kpool /kinetics/CaMKII-act 1 0 0 0 0 0 0 0 0 6e+05 0 0 "" blue \ black simundump kpool /kinetics/CaN-active 1 0 0 0 0 0 0 0 0 6e+05 0 0 "" blue \ black simundump kpool /kinetics/tot_PP1-act 1 1.8 0 0 0 0 0 1.08e+06 0 6e+05 0 0 "" \ red black simundump xgraph /graphs/conc1 0 0 8000 0 0.4 0 simundump xgraph /graphs/conc2 0 0 8000 0 0.3 0 simundump xplot /graphs/conc1/PKC-active.Co 3 524288 \ "delete_plot.w ; edit_plot.D " red 0 0 1 simundump xplot /graphs/conc1/MAPK*.Co 3 524288 \ "delete_plot.w ; edit_plot.D " orange 0 0 1 simundump xplot /graphs/conc2/PKA-active.Co 3 524288 \ "delete_plot.w ; edit_plot.D " yellow 0 0 1 simundump xgraph /moregraphs/conc3 0 0 8000 0 35 0 simundump xgraph /moregraphs/conc4 0 0 8000 0 1.5 0 simundump xplot /moregraphs/conc3/CaMKII-act.Co 3 524288 \ "delete_plot.w ; edit_plot.D " blue 0 0 1 simundump xplot /moregraphs/conc3/Ca.Co 3 524288 \ "delete_plot.w ; edit_plot.D " red 0 0 1 simundump xplot /moregraphs/conc4/CaN-active.Co 3 524288 \ "delete_plot.w ; edit_plot.D " blue 0 0 1 simundump xplot /moregraphs/conc4/tot_PP1-act.Co 3 524288 \ "delete_plot.w ; edit_plot.D " red 0 0 1 simundump xcoredraw /edit/draw 0 -39.507 -19.76 -13.114 6.6328 simundump xtree /edit/draw/tree 0 /kinetics/##[] \ "edit_elm.D ; drag_from_edit.w " auto 0.6 call /edit/draw/tree ADDMSGARROW \ select all all all none -1000 0 \ "" "" "" call /edit/draw/tree ADDMSGARROW \ /kinetics/##[] /kinetics/##[TYPE=group] all all none -1001 0 \ "echo.p dragging onto group ; thing_to_group_add.p " "" "" call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kpool] /kinetics/##[TYPE=kpool] SUMTOTAL kpool darkgreen -1002 0 \ "echo.p dragging to for sumtotal" "pool_to_pool_add_sumtot.p " "pool_to_pool_drop_sumtot.p " call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kpool] /kinetics/##[TYPE=kpool] CONSERVE kpool blue -1003 0 \ "echo.p dragging to for conserve" "pool_to_pool_add_consv.p " "pool_to_pool_drop_consv.p " call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kreac] /kinetics/##[TYPE=kpool] REAC kpool none -1004 0 \ "echo.p dragging to for product" "reac_to_pool_add.p " "reac_to_pool_drop.p " call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kpool] /kinetics/##[TYPE=kreac] SUBSTRATE kreac green -1005 0 \ "echo.p dragging to for substrate" "pool_to_reac_add.p " "pool_to_reac_drop.p " call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kpool] /kinetics/##[TYPE=kreac] KF kreac purple -1006 0 \ "" "" "" call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kpool] /kinetics/##[TYPE=kreac] KB kreac hotpink -1007 0 \ "" "" "" call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kpool] /kinetics/##[TYPE=kreac] PRODUCT kreac green -1008 1 \ "" "" "" call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kenz] /kinetics/##[TYPE=kpool] MM_PRD kpool red -1009 0 \ "echo.p dragging to for enz product" "enz_to_pool_add.p " "enz_to_pool_drop.p " call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kpool] /kinetics/##[TYPE=kenz] SUBSTRATE kenz red -1010 0 \ "echo.p dragging to for enz substrate" "pool_to_enz_add.p " "pool_to_enz_drop.p " call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kenz] /kinetics/##[TYPE=kpool] SUMTOTAL kpool darkgreen -1011 0 \ "" "" "" call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kenz] /kinetics/##[TYPE=kpool] CONSERVE kpool blue -1012 0 \ "" "" "" call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kpool] /kinetics/##[TYPE=kenz] INTRAMOL kenz white -1013 0 \ "" "" "" call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=stim] /kinetics/##[TYPE=kpool] SLAVE kpool orange -1014 0 \ "echo.p dragging to for stimulus" "stim_to_pool_add.p " "stim_to_pool_drop.p " call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=stim] /kinetics/##[TYPE=stim] INPUT stim orange -1015 0 \ "echo.p dragging to for stim" "stim_to_stim_add.p " "stim_to_stim_drop.p " call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=xtab] /kinetics/##[TYPE=kpool] SLAVE kpool orange -1016 0 \ "echo.p dragging to for xtab" "xtab_to_pool_add.p " "xtab_to_pool_drop.p " call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=xtab] /kinetics/##[TYPE=xtab] INPUT xtab orange -1017 0 \ "echo.p dragging to for xtab" "xtab_to_xtab_add.p " "xtab_to_xtab_drop.p " call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kpool] /kinetics/##[TYPE=xtab] INPUT xtab hotpink -1018 0 \ "echo.p dragging to for xtab" "pool_to_xtab_add.p " "pool_to_xtab_drop.p " call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kchan] /kinetics/##[TYPE=kpool] REAC kpool none -1019 0 \ "echo.p dragging to for chan product" "chan_to_pool_add.p " "chan_to_pool_drop.p " call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kpool] /kinetics/##[TYPE=kchan] PRODUCT kchan orange -1020 1 \ "" "" "" call /edit/draw/tree ADDMSGARROW \ /kinetics/##[TYPE=kpool] /kinetics/##[TYPE=kchan] SUBSTRATE kchan orange -1021 0 \ "echo.p dragging to for chan substrate" "pool_to_chan_add.p " "pool_to_chan_drop.p " call /edit/draw/tree UNDUMP 100 \ "/kinetics/PKC" -3.04929 8.21631 0 \ "/kinetics/PKC/PKC-Ca" -4.07517 1.51085 0 \ "/kinetics/PKC/PKC-act-by-Ca" -4.07517 -0.122947 0 \ "/kinetics/PKC/PKC-act-by-DAG" -2.06118 0.693953 0 \ "/kinetics/PKC/PKC-Ca-to-memb" -3.79738 4.25331 0 \ "/kinetics/PKC/PKC-DAG-to-memb" -2.61677 2.73621 0 \ "/kinetics/PKC/PKC-act-by-Ca-AA" -0.78797 3.81568 0 \ "/kinetics/PKC/PKC-act-by-DAG-AA" 1.24916 3.23218 0 \ "/kinetics/PKC/PKC-DAG-AA*" 0.600985 5.53701 0 \ "/kinetics/PKC/PKC-Ca-AA*" -0.602776 6.29557 0 \ "/kinetics/PKC/PKC-Ca-memb*" -2.77881 6.52897 0 \ "/kinetics/PKC/PKC-DAG-memb*" -1.82969 5.50784 0 \ "/kinetics/PKC/PKC-basal*" -4.7465 5.56619 0 \ "/kinetics/PKC/PKC-basal-act" -4.97799 3.05713 0 \ "/kinetics/PKC/PKC-AA*" 1.78159 6.82072 0 \ "/kinetics/PKC/PKC-act-by-AA" -4.99245 -1.86537 0 \ "/kinetics/PKC/PKC-Ca-DAG" 0.230597 1.8026 0 \ "/kinetics/PKC/PKC-n-DAG" -3.0103 -1.99016 0 \ "/kinetics/PKC/PKC-DAG" -0.996314 -1.08573 0 \ "/kinetics/PKC/PKC-n-DAG-AA" -1.22781 -2.95294 0 \ "/kinetics/PKC/PKC-DAG-AA" 0.624134 0.227153 0 \ "/kinetics/PKC/PKC-cytosolic" -6.13155 0.597108 0 \ "/kinetics/DAG" -3.20515 -4.71675 0 \ "/kinetics/Ca" -19.3 10.35 0 \ "/kinetics/AA" -3.28976 -9.33758 0 \ "/kinetics/PKC-active" 2.13247 8.47704 0 \ "/kinetics/PKC-active/PKC-act-raf" 6.2532 10.5492 0 \ "/kinetics/PKC-active/PKC-inact-GAP" 3.43912 11.8042 0 \ "/kinetics/PKC-active/PKC-act-GEF" -0.247906 17.2639 0 \ "/kinetics/PKC-active/PKC-phosph-neurogranin" -49.0052 -4.4126 0 \ "/kinetics/PKC-active/PKC-phosph-ng-CaM" -52.4412 -1.6274 0 \ "/kinetics/PKC-active/phosph-AC2" -16.8145 -21.2799 0 \ "/kinetics/PLA2" -7.35718 -14.2086 0 \ "/kinetics/PLA2/PLA2-cytosolic" -11.8243 -8.94209 0 \ "/kinetics/PLA2/PLA2-Ca-act" -11.097 -11.1044 0 \ "/kinetics/PLA2/PLA2-Ca*" -8.72196 -11.646 0 \ "/kinetics/PLA2/PLA2-Ca*/kenz" -6.0553 -11.6669 0 \ "/kinetics/PLA2/PIP2-PLA2-act" -11.0553 -6.75022 0 \ "/kinetics/PLA2/PIP2-PLA2*" -8.6803 -6.29188 0 \ "/kinetics/PLA2/PIP2-PLA2*/kenz" -6.03446 -6.27105 0 \ "/kinetics/PLA2/PIP2-Ca-PLA2-act" -10.097 -7.50022 0 \ "/kinetics/PLA2/PIP2-Ca-PLA2*" -8.32613 -7.89605 0 \ "/kinetics/PLA2/PIP2-Ca-PLA2*/kenz" -5.97196 -7.97938 0 \ "/kinetics/PLA2/DAG-Ca-PLA2-act" -10.8261 -9.83355 0 \ "/kinetics/PLA2/DAG-Ca-PLA2*" -8.13863 -10.4794 0 \ "/kinetics/PLA2/DAG-Ca-PLA2*/kenz" -5.95113 -10.3544 0 \ "/kinetics/PLA2/APC" -8.23862 -9.96337 0 \ "/kinetics/PLA2/Degrade-AA" -6.1808 -5.2875 0 \ "/kinetics/PLA2/PLA2*-Ca" -7.81296 -12.6868 0 \ "/kinetics/PLA2/PLA2*-Ca/kenz" -6.08142 -12.8166 0 \ "/kinetics/PLA2/PLA2*" -9.02503 -14.8512 0 \ "/kinetics/PLA2/PLA2*-Ca-act" -10.0856 -12.7517 0 \ "/kinetics/PLA2/dephosphorylate-PLA2*" -13.6928 -11.7346 0 \ "/kinetics/MAPK*" 12.4924 0.776017 0 \ "/kinetics/MAPK*/MAPK*" -12.0046 -14.9398 0 \ "/kinetics/MAPK*/MAPK*-feedback" 10.3875 10.6685 0 \ "/kinetics/temp-PIP2" -15.7959 -7.04735 0 \ "/kinetics/IP3" -0.773746 -4.6555 0 \ "/kinetics/Glu" -0.79501 13.884 0 \ "/kinetics/PLCbeta" 8.58463 -17.4677 0 \ "/kinetics/PLCbeta/Act-PLC-Ca" 3.07087 -16.9779 0 \ "/kinetics/PLCbeta/PLC" 10.6971 -16.9571 0 \ "/kinetics/PLCbeta/Degrade-IP3" 2.31251 -7.97049 0 \ "/kinetics/PLCbeta/Inositol" 4.96525 -8.74164 0 \ "/kinetics/PLCbeta/Degrade-DAG" -0.957152 -7.26102 0 \ "/kinetics/PLCbeta/PC" 4.90356 -7.13764 0 \ "/kinetics/PLCbeta/PLC-Ca" 7.01472 -12.7974 0 \ "/kinetics/PLCbeta/PLC-Ca/PLC-Ca" -2.25113 -11.6971 0 \ "/kinetics/PLCbeta/Act-PLC-by-Gq" 2.69957 -15.1627 0 \ "/kinetics/PLCbeta/Inact-PLC-Gq" 11.1254 -10.3136 0 \ "/kinetics/PLCbeta/PLC-Ca-Gq" 10.6289 -13.4111 0 \ "/kinetics/PLCbeta/PLC-Ca-Gq/PLCb-Ca-Gq" 2.9471 -11.0783 0 \ "/kinetics/PLCbeta/PLC-Gq" 15.0351 -13.5371 0 \ "/kinetics/PLCbeta/PLC-bind-Gq" 14.7463 -16.263 0 \ "/kinetics/PLCbeta/PLC-Gq-bind-Ca" 14.0037 -11.254 0 \ "/kinetics/PIP2" -0.031142 -11.1327 0 \ "/kinetics/BetaGamma" 15.7872 -2.61633 0 \ "/kinetics/G*GTP" 7.31492 -7.01314 0 \ "/kinetics/G*GDP" 13.5603 -5.65294 0 \ "/kinetics/Gq" 12.7451 -1.94366 0 \ "/kinetics/Gq/RecLigandBinding" 7.33876 -3.17897 0 \ "/kinetics/Gq/G-GDP" 10.6804 -2.57292 0 \ "/kinetics/Gq/Basal-Act-G" 9.805 -4.82245 0 \ "/kinetics/Gq/Trimerize-G" 12.2554 -4.78314 0 \ "/kinetics/Gq/Inact-G" 10.2179 -7.60948 0 \ "/kinetics/Gq/mGluR" 6.46376 -1.76231 0 \ "/kinetics/Gq/Rec-Glu" 5.81081 -3.72166 0 \ "/kinetics/Gq/Rec-Gq" 4.07675 -0.999425 0 \ "/kinetics/Gq/Rec-Glu-bind-Gq" 4.7148 -2.42249 0 \ "/kinetics/Gq/Glu-bind-Rec-Gq" 2.38597 -3.03705 0 \ "/kinetics/Gq/Rec-Glu-Gq" 4.74161 -5.11656 0 \ "/kinetics/Gq/Activate-Gq" 7.01724 -4.65725 0 \ "/kinetics/Gq/Rec-bind-Gq" 6.74297 -0.0889989 0 \ "/kinetics/Gq/mGluRAntag" 0.602158 -2.30905 0 \ "/kinetics/Gq/Antag-bind-Rec-Gq" 2.13987 -4.2806 0 \ "/kinetics/Gq/Blocked-rec-Gq" 2.46024 -5.98151 0 \ "/kinetics/MAPK" 14.6165 11.1912 0 \ "/kinetics/MAPK/craf-1" 6.32605 8.11685 0 \ "/kinetics/MAPK/craf-1*" 9.2401 7.71145 0 \ "/kinetics/MAPK/MAPKK" 6.33153 3.98944 0 call /edit/draw/tree UNDUMP 100 \ "/kinetics/MAPK/MAPK" 6.06559 1.08628 0 \ "/kinetics/MAPK/craf-1**" 12.4638 7.90223 0 \ "/kinetics/MAPK/MAPK-tyr" 8.4147 0.82034 0 \ "/kinetics/MAPK/MAPKK*" 12.5477 4.02564 0 \ "/kinetics/MAPK/MAPKK*/MAPKKtyr" 8.89145 3.55309 0 \ "/kinetics/MAPK/MAPKK*/MAPKKthr" 12.9613 3.03628 0 \ "/kinetics/MAPK/MAPKK-ser" 9.26524 4.16569 0 \ "/kinetics/MAPK/Raf-GTP-Ras*" 4.90545 6.78143 0 \ "/kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.1" 7.61789 6.21889 0 \ "/kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.2" 10.6978 6.06883 0 \ "/kinetics/MKP-1" 5.0816 2.44073 0 \ "/kinetics/MKP-1/MKP1-tyr-deph" 6.27806 3.06838 0 \ "/kinetics/MKP-1/MKP1-thr-deph" 10.7893 2.93108 0 \ "/kinetics/Ras-act-craf" 3.5614 10.091 0 \ "/kinetics/PPhosphatase2A" 9.3898 9.13091 0 \ "/kinetics/PPhosphatase2A/craf-deph" 7.80129 10.2154 0 \ "/kinetics/PPhosphatase2A/MAPKK-deph" 13.159 6.07359 0 \ "/kinetics/PPhosphatase2A/MAPKK-deph-ser" 4.8651 5.92081 0 \ "/kinetics/PPhosphatase2A/craf**-deph" 12.4456 9.90537 0 \ "/kinetics/Ras" 14.5128 16.351 0 \ "/kinetics/Ras/bg-act-GEF" 13.4677 14.8376 0 \ "/kinetics/Ras/GEF-Gprot-bg" 10.3734 17.2707 0 \ "/kinetics/Ras/GEF-Gprot-bg/GEF-bg_act-ras" 10.4022 16.5232 0 \ "/kinetics/Ras/dephosph-GEF" 9.07016 17.8808 0 \ "/kinetics/Ras/inact-GEF" 12.4531 18.3522 0 \ "/kinetics/Ras/GEF*" 6.4483 17.246 0 \ "/kinetics/Ras/GEF*/GEF*-act-ras" 7.0855 16.086 0 \ "/kinetics/Ras/GTP-Ras" 12.564 13.0836 0 \ "/kinetics/Ras/GDP-Ras" 6.13087 14.1651 0 \ "/kinetics/Ras/Ras-intrinsic-GTPase" 9.09789 13.4996 0 \ "/kinetics/Ras/dephosph-GAP" 4.02345 15.5238 0 \ "/kinetics/Ras/GAP*" 1.3498 14.349 0 \ "/kinetics/Ras/GAP" 6.6549 12.3377 0 \ "/kinetics/Ras/GAP/GAP-inact-ras" 9.01211 12.4032 0 \ "/kinetics/Ras/inact-GEF*" 15.029 19.16 0 \ "/kinetics/Ras/CaM-bind-GEF" 2.4861 21.679 0 \ "/kinetics/Ras/CaM-GEF" 5.3451 19.58 0 \ "/kinetics/Ras/CaM-GEF/CaM-GEF-act-ras" 5.0223 18.657 0 \ "/kinetics/Ras/dephosph-inact-GEF*" 14.431 21.995 0 \ "/kinetics/PKA-active" -33.5853 -12.8579 0 \ "/kinetics/PKA-active/PKA-phosph-GEF" 10.4635 21.469 0 \ "/kinetics/PKA-active/PKA-phosph-I1" -36.8942 -17.1139 0 \ "/kinetics/PKA-active/PKA-phosph-GAP" -33.8917 -19.7469 0 \ "/kinetics/PKA-active/phosph-PDE" -30.9338 -13.3169 0 \ "/kinetics/CaM-Ca4" -22.0749 -2.8669 0 \ "/kinetics/CaMKII" -22.4007 3.97427 0 \ "/kinetics/CaMKII/CaMKII" -23.819 3.271 0 \ "/kinetics/CaMKII/CaMKII-CaM" -27.443 3.0376 0 \ "/kinetics/CaMKII/CaMKII-thr286*-CaM" -27.7026 1.6156 0 \ "/kinetics/CaMKII/CaMKII***" -27.6158 -1.6238 0 \ "/kinetics/CaMKII/CaMKII-bind-CaM" -23.2983 1.5267 0 \ "/kinetics/CaMKII/CaMK-thr286-bind-CaM" -23.2766 0.92147 0 \ "/kinetics/CaMKII/CaMKII-thr286" -27.5507 -0.09309 0 \ "/kinetics/CaMKII/CaMK-thr306" -27.5388 -3.2652 0 \ "/kinetics/CaMKII/total-CaMKII" -27.8395 4.1393 0 \ "/kinetics/CaMKII/basal-activity" -25.3689 -0.16228 0 \ "/kinetics/CaMKII/tot_CaM_CaMKII" -31.7152 3.2973 0 \ "/kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_305" -29.5513 0.6145 0 \ "/kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_286" -25.5964 2.816 0 \ "/kinetics/CaMKII/tot_autonomous_CaMKII" -32.0636 2.3272 0 \ "/kinetics/CaMKII/tot_autonomous_CaMKII/auton_305" -29.7357 -0.41162 0 \ "/kinetics/CaMKII/tot_autonomous_CaMKII/auton_286" -25.4734 1.9951 0 \ "/kinetics/PP1-active" -31.4482 0.139749 0 \ "/kinetics/PP1-active/Deph-thr286" -31.0967 1.7813 0 \ "/kinetics/PP1-active/Deph-thr305" -30.3132 -1.10523 0 \ "/kinetics/PP1-active/Deph-thr306" -25.5375 3.7223 0 \ "/kinetics/PP1-active/Deph-thr286c" -30.3339 -2.8165 0 \ "/kinetics/PP1-active/Deph_thr286b" -24.7576 -1.1185 0 \ "/kinetics/CaM" -45.327 -3.61012 0 \ "/kinetics/CaM/CaM" -45.344 4.10958 0 \ "/kinetics/CaM/CaM-TR2-bind-Ca" -43.1651 3.46878 0 \ "/kinetics/CaM/CaM-TR2-Ca2-bind-Ca" -44.1692 1.61518 0 \ "/kinetics/CaM/CaM-Ca3-bind-Ca" -45.7267 -1.35052 0 \ "/kinetics/CaM/neurogranin-CaM" -54.9379 -4.13842 0 \ "/kinetics/CaM/neurogranin-bind-CaM" -50.9576 -3.70132 0 \ "/kinetics/CaM/neurogranin*" -47.8699 -6.80582 0 \ "/kinetics/CaM/neurogranin" -52.5684 -6.81612 0 \ "/kinetics/CaM/dephosph-neurogranin" -45.7552 -5.1411 0 \ "/kinetics/CaM-Ca3" -41.8382 -0.21314 0 \ "/kinetics/CaM-TR2-Ca2" -40.3282 2.6476 0 \ "/kinetics/CaM(Ca)n-CaNAB" -30.524 -6.6543 0 \ "/kinetics/CaM(Ca)n-CaNAB/dephosph_neurogranin" -51.0472 -9.2181 0 \ "/kinetics/CaM(Ca)n-CaNAB/dephosph_inhib1" -42.7422 -17.3569 0 \ "/kinetics/CaM(Ca)n-CaNAB/dephosph-PP1-I*" -41.2402 -6.4435 0 \ "/kinetics/PP1" -46.3622 -10.2349 0 \ "/kinetics/PP1/I1" -38.0134 -14.3513 0 \ "/kinetics/PP1/I1*" -42.1577 -14.3193 0 \ "/kinetics/PP1/Inact-PP1" -45.4032 -12.4173 0 \ "/kinetics/PP1/PP1-I1*" -43.7472 -8.9641 0 \ "/kinetics/PP1/PP1-I1" -36.3389 -8.6879 0 \ "/kinetics/PP1/dissoc-PP1-I1" -42.4982 -12.141 0 \ "/kinetics/PP2A" -36.5202 -3.6325 0 \ "/kinetics/PP2A/PP2A-dephosph-I1" -38.9542 -10.6632 0 \ "/kinetics/PP2A/PP2A-dephosph-PP1-I*" -36.5212 -4.7733 0 \ "/kinetics/CaNAB-Ca4" -24.9234 -8.5717 0 \ "/kinetics/CaNAB-Ca4/dephosph_inhib1_noCaM" -35.5392 -10.4959 0 \ "/kinetics/PP2B" -20.0524 -5.8546 0 \ "/kinetics/PP2B/CaNAB" -18.7021 -8.4456 0 \ "/kinetics/PP2B/CaNAB-Ca2" -21.2581 -8.5373 0 \ "/kinetics/PP2B/Ca-bind-CaNAB-Ca2" -22.8255 -9.7525 0 call /edit/draw/tree UNDUMP 63 \ "/kinetics/PP2B/Ca-bind-CaNAB" -20.1248 -9.8899 0 \ "/kinetics/PP2B/CaM-Ca2-bind-CaNAB" -26.9624 -9.3156 0 \ "/kinetics/PP2B/CaMCa3-CaNAB" -29.6674 -10.7539 0 \ "/kinetics/PP2B/CaMCa2-CANAB" -27.5259 -10.6889 0 \ "/kinetics/PP2B/CaMCa4-CaNAB" -30.9973 -9.6161 0 \ "/kinetics/PP2B/CaMCa3-bind-CaNAB" -27.5935 -8.6073 0 \ "/kinetics/PP2B/CaMCa4-bind-CaNAB" -27.6386 -7.6415 0 \ "/kinetics/PKA" -41.9432 -20.6669 0 \ "/kinetics/PKA/R2C2" -46.6556 -27.7395 0 \ "/kinetics/PKA/R2C2-cAMP" -43.6937 -27.2717 0 \ "/kinetics/PKA/cAMP-bind-site-B1" -44.2792 -31.0146 0 \ "/kinetics/PKA/cAMP-bind-site-B2" -41.9373 -29.767 0 \ "/kinetics/PKA/cAMP-bind-site-A1" -39.2509 -30.9522 0 \ "/kinetics/PKA/cAMP-bind-site-A2" -35.9637 -29.521 0 \ "/kinetics/PKA/R2C2-cAMP2" -40.1464 -26.4295 0 \ "/kinetics/PKA/R2C2-cAMP3" -37.46 -27.49 0 \ "/kinetics/PKA/R2C2-cAMP4" -35.0735 -25.8789 0 \ "/kinetics/PKA/R2C-cAMP4" -37.3567 -24.7452 0 \ "/kinetics/PKA/R2-cAMP4" -43.6937 -25.1818 0 \ "/kinetics/PKA/Release-C1" -35.3611 -22.8769 0 \ "/kinetics/PKA/Release-C2" -40.2321 -24.1549 0 \ "/kinetics/PKA/PKA-inhibitor" -44.7139 -23.2878 0 \ "/kinetics/PKA/inhib-PKA" -41.9207 -22.6645 0 \ "/kinetics/PKA/inhibited-PKA" -45.3409 -21.6889 0 \ "/kinetics/cAMP" -30.1565 -32.5909 0 \ "/kinetics/AC" -17.5289 -17.4699 0 \ "/kinetics/AC/ATP" -18.0421 -18.8679 0 \ "/kinetics/AC/AC1-CaM" -20.4826 -17.2589 0 \ "/kinetics/AC/AC1-CaM/kenz" -20.5204 -18.3939 0 \ "/kinetics/AC/AC1" -24.2474 -15.394 0 \ "/kinetics/AC/CaM-bind-AC1" -22.7622 -15.5895 0 \ "/kinetics/AC/AC2*" -18.6472 -22.5199 0 \ "/kinetics/AC/AC2*/kenz" -18.7735 -21.6629 0 \ "/kinetics/AC/AC2-Gs" -21.4855 -21.7089 0 \ "/kinetics/AC/AC2-Gs/kenz" -21.5644 -20.7009 0 \ "/kinetics/AC/AC2" -17.6064 -24.3029 0 \ "/kinetics/AC/dephosph-AC2" -19.7587 -25.1079 0 \ "/kinetics/AC/AC1-Gs" -22.9202 -16.5069 0 \ "/kinetics/AC/AC1-Gs/kenz" -21.9446 -17.6549 0 \ "/kinetics/AC/Gs-bind-AC2" -20.17 -27.1419 0 \ "/kinetics/AC/Gs-bind-AC1" -24.8794 -16.8829 0 \ "/kinetics/AC/AMP" -23.6494 -17.4699 0 \ "/kinetics/AC/AC2*-Gs" -20.142 -22.1409 0 \ "/kinetics/AC/AC2*-Gs/kenz" -20.0663 -21.0869 0 \ "/kinetics/AC/Gs-bind-AC2*" -20.3432 -23.9909 0 \ "/kinetics/AC/cAMP-PDE" -26.7119 -15.6959 0 \ "/kinetics/AC/cAMP-PDE/PDE" -26.8206 -23.1309 0 \ "/kinetics/AC/cAMP-PDE*" -26.6851 -17.7799 0 \ "/kinetics/AC/cAMP-PDE*/PDE*" -25.438 -22.3049 0 \ "/kinetics/AC/dephosph-PDE" -28.5867 -18.8419 0 \ "/kinetics/AC/PDE1" -30.4925 -12.1152 0 \ "/kinetics/AC/PDE1/PDE1" -27.4255 -22.0689 0 \ "/kinetics/AC/CaM.PDE1" -30.4925 -14.8499 0 \ "/kinetics/AC/CaM.PDE1/CaM.PDE1" -28.3329 -21.2819 0 \ "/kinetics/AC/CaM_bind_PDE1" -27.2799 -13.2929 0 \ "/kinetics/Gs-alpha" -23.6771 -28.0299 0 \ "/kinetics/Ca_tab" -22.628 15.274 0 \ "/kinetics/remove_glu" 0.90738 16.118 0 \ "/kinetics/stim" -3.3486 17.057 0 \ "/kinetics/synapse" -1.1355 18.481 0 \ "/kinetics/CaMKII-act" -36.512 3.6708 0 \ "/kinetics/CaN-active" -26.946 -4.8908 0 \ "/kinetics/tot_PP1-act" -36.715 0.73835 0 simundump xtext /file/notes 0 1 xtextload /file/notes \ "all125 plus plots plus stims." \ "Eliminated notes for portability." addmsg /kinetics/PKC/PKC-act-by-Ca /kinetics/PKC/PKC-Ca REAC B A addmsg /kinetics/PKC/PKC-act-by-DAG /kinetics/PKC/PKC-Ca REAC A B addmsg /kinetics/PKC/PKC-Ca-to-memb /kinetics/PKC/PKC-Ca REAC A B addmsg /kinetics/PKC/PKC-act-by-Ca-AA /kinetics/PKC/PKC-Ca REAC A B addmsg /kinetics/PKC/PKC-cytosolic /kinetics/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/Ca /kinetics/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/DAG /kinetics/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/PKC/PKC-Ca-DAG /kinetics/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/PKC/PKC-Ca-memb* /kinetics/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/PKC/PKC-Ca-DAG /kinetics/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/PKC/PKC-DAG-memb* /kinetics/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/AA /kinetics/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/PKC/PKC-Ca-AA* /kinetics/PKC/PKC-act-by-Ca-AA PRODUCT n addmsg /kinetics/PKC/PKC-DAG-AA* /kinetics/PKC/PKC-act-by-DAG-AA PRODUCT n addmsg /kinetics/PKC/PKC-DAG-AA /kinetics/PKC/PKC-act-by-DAG-AA SUBSTRATE n addmsg /kinetics/PKC/PKC-act-by-DAG-AA /kinetics/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/PKC/PKC-act-by-Ca-AA /kinetics/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/PKC/PKC-Ca-to-memb /kinetics/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/PKC/PKC-DAG-to-memb /kinetics/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/PKC/PKC-basal-act /kinetics/PKC/PKC-basal* REAC B A addmsg /kinetics/PKC/PKC-cytosolic /kinetics/PKC/PKC-basal-act SUBSTRATE n addmsg /kinetics/PKC/PKC-basal* /kinetics/PKC/PKC-basal-act PRODUCT n addmsg /kinetics/PKC/PKC-act-by-AA /kinetics/PKC/PKC-AA* REAC B A addmsg /kinetics/AA /kinetics/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/PKC/PKC-AA* /kinetics/PKC/PKC-act-by-AA PRODUCT n addmsg /kinetics/PKC/PKC-cytosolic /kinetics/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/PKC/PKC-act-by-DAG /kinetics/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/PKC/PKC-DAG-to-memb /kinetics/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/PKC/PKC-cytosolic /kinetics/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/DAG /kinetics/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/PKC/PKC-DAG /kinetics/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/PKC/PKC-n-DAG /kinetics/PKC/PKC-DAG REAC B A addmsg /kinetics/PKC/PKC-n-DAG-AA /kinetics/PKC/PKC-DAG REAC A B addmsg /kinetics/PKC/PKC-DAG /kinetics/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/AA /kinetics/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/PKC/PKC-DAG-AA /kinetics/PKC/PKC-n-DAG-AA PRODUCT n addmsg /kinetics/PKC/PKC-n-DAG-AA /kinetics/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/PKC/PKC-act-by-DAG-AA /kinetics/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/PKC/PKC-act-by-Ca /kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/PKC/PKC-basal-act /kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/PKC/PKC-act-by-AA /kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/PKC/PKC-n-DAG /kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/PKC/PKC-act-by-DAG /kinetics/DAG REAC A B addmsg /kinetics/PKC/PKC-n-DAG /kinetics/DAG REAC A B addmsg /kinetics/PLA2/DAG-Ca-PLA2-act /kinetics/DAG REAC A B addmsg /kinetics/PLCbeta/PLC-Ca-Gq/PLCb-Ca-Gq /kinetics/DAG MM_PRD pA addmsg /kinetics/PLCbeta/Degrade-DAG /kinetics/DAG REAC A B addmsg /kinetics/PLCbeta/PLC-Ca/PLC-Ca /kinetics/DAG MM_PRD pA addmsg /kinetics/PKC/PKC-act-by-Ca /kinetics/Ca REAC A B addmsg /kinetics/PLA2/PLA2-Ca-act /kinetics/Ca REAC A B addmsg /kinetics/PLA2/PLA2*-Ca-act /kinetics/Ca REAC A B addmsg /kinetics/PLCbeta/Act-PLC-Ca /kinetics/Ca REAC A B addmsg /kinetics/PLCbeta/PLC-Gq-bind-Ca /kinetics/Ca REAC A B addmsg /kinetics/CaM/CaM-TR2-bind-Ca /kinetics/Ca REAC A B addmsg /kinetics/CaM/CaM-TR2-bind-Ca /kinetics/Ca REAC A B addmsg /kinetics/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/Ca REAC A B addmsg /kinetics/CaM/CaM-Ca3-bind-Ca /kinetics/Ca REAC A B addmsg /kinetics/PP2B/Ca-bind-CaNAB-Ca2 /kinetics/Ca REAC A B addmsg /kinetics/PP2B/Ca-bind-CaNAB-Ca2 /kinetics/Ca REAC A B addmsg /kinetics/PP2B/Ca-bind-CaNAB /kinetics/Ca REAC A B addmsg /kinetics/PP2B/Ca-bind-CaNAB /kinetics/Ca REAC A B addmsg /kinetics/Ca_tab /kinetics/Ca SLAVE output addmsg /kinetics/PKC/PKC-act-by-Ca-AA /kinetics/AA REAC A B addmsg /kinetics/PKC/PKC-act-by-AA /kinetics/AA REAC A B addmsg /kinetics/PKC/PKC-n-DAG-AA /kinetics/AA REAC A B addmsg /kinetics/PLA2/PLA2-Ca*/kenz /kinetics/AA MM_PRD pA addmsg /kinetics/PLA2/PIP2-PLA2*/kenz /kinetics/AA MM_PRD pA addmsg /kinetics/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/AA MM_PRD pA addmsg /kinetics/PLA2/DAG-Ca-PLA2*/kenz /kinetics/AA MM_PRD pA addmsg /kinetics/PLA2/PLA2*-Ca/kenz /kinetics/AA MM_PRD pA addmsg /kinetics/PLA2/Degrade-AA /kinetics/AA REAC A B addmsg /kinetics/PKC/PKC-DAG-AA* /kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/PKC/PKC-Ca-memb* /kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/PKC/PKC-Ca-AA* /kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/PKC/PKC-DAG-memb* /kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/PKC/PKC-basal* /kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/PKC/PKC-AA* /kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/PKC-active/PKC-act-raf /kinetics/PKC-active REAC sA B addmsg /kinetics/PKC-active/PKC-act-raf /kinetics/PKC-active CONSERVE nComplex nComplexInit addmsg /kinetics/PKC-active/PKC-inact-GAP /kinetics/PKC-active REAC eA B addmsg /kinetics/PKC-active/PKC-inact-GAP /kinetics/PKC-active CONSERVE nComplex nComplexInit addmsg /kinetics/PKC-active/PKC-act-GEF /kinetics/PKC-active REAC eA B addmsg /kinetics/PKC-active/PKC-act-GEF /kinetics/PKC-active CONSERVE nComplex nComplexInit addmsg /kinetics/PKC-active/PKC-phosph-neurogranin /kinetics/PKC-active REAC eA B addmsg /kinetics/PKC-active/PKC-phosph-ng-CaM /kinetics/PKC-active REAC eA B addmsg /kinetics/PKC-active/phosph-AC2 /kinetics/PKC-active REAC eA B addmsg /kinetics/PKC-active /kinetics/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/MAPK/craf-1 /kinetics/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/PKC-active /kinetics/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/Ras/GAP /kinetics/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/PKC-active /kinetics/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/Ras/inact-GEF /kinetics/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/PKC-active /kinetics/PKC-active/PKC-phosph-neurogranin ENZYME n addmsg /kinetics/CaM/neurogranin /kinetics/PKC-active/PKC-phosph-neurogranin SUBSTRATE n addmsg /kinetics/PKC-active /kinetics/PKC-active/PKC-phosph-ng-CaM ENZYME n addmsg /kinetics/CaM/neurogranin-CaM /kinetics/PKC-active/PKC-phosph-ng-CaM SUBSTRATE n addmsg /kinetics/PKC-active /kinetics/PKC-active/phosph-AC2 ENZYME n addmsg /kinetics/AC/AC2 /kinetics/PKC-active/phosph-AC2 SUBSTRATE n addmsg /kinetics/PLA2/PLA2-Ca-act /kinetics/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/PLA2/PIP2-PLA2-act /kinetics/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/PLA2/PIP2-PLA2* /kinetics/PLA2/PLA2-cytosolic CONSERVE n nInit addmsg /kinetics/PLA2/PIP2-Ca-PLA2* /kinetics/PLA2/PLA2-cytosolic CONSERVE n nInit addmsg /kinetics/PLA2/DAG-Ca-PLA2* /kinetics/PLA2/PLA2-cytosolic CONSERVE n nInit addmsg /kinetics/PLA2/PLA2-Ca* /kinetics/PLA2/PLA2-cytosolic CONSERVE n nInit addmsg /kinetics/PLA2/PLA2*-Ca /kinetics/PLA2/PLA2-cytosolic CONSERVE n nInit addmsg /kinetics/MAPK*/MAPK* /kinetics/PLA2/PLA2-cytosolic CONSERVE nComplex nComplexInit addmsg /kinetics/PLA2/PLA2*-Ca/kenz /kinetics/PLA2/PLA2-cytosolic CONSERVE nComplex nComplexInit addmsg /kinetics/PLA2/PLA2-Ca*/kenz /kinetics/PLA2/PLA2-cytosolic CONSERVE nComplex nComplexInit addmsg /kinetics/PLA2/DAG-Ca-PLA2*/kenz /kinetics/PLA2/PLA2-cytosolic CONSERVE nComplex nComplexInit addmsg /kinetics/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/PLA2/PLA2-cytosolic CONSERVE nComplex nComplexInit addmsg /kinetics/PLA2/PIP2-PLA2*/kenz /kinetics/PLA2/PLA2-cytosolic CONSERVE nComplex nComplexInit addmsg /kinetics/MAPK*/MAPK* /kinetics/PLA2/PLA2-cytosolic REAC sA B addmsg /kinetics/PLA2/PLA2* /kinetics/PLA2/PLA2-cytosolic CONSERVE n nInit addmsg /kinetics/PLA2/dephosphorylate-PLA2* /kinetics/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/PLA2/PLA2-cytosolic /kinetics/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/Ca /kinetics/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/PLA2/PLA2-Ca* /kinetics/PLA2/PLA2-Ca-act PRODUCT n addmsg /kinetics/PLA2/PLA2-Ca-act /kinetics/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/PLA2/PLA2-Ca*/kenz /kinetics/PLA2/PLA2-Ca* REAC eA B addmsg /kinetics/PLA2/PIP2-Ca-PLA2-act /kinetics/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/PLA2/DAG-Ca-PLA2-act /kinetics/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/PLA2/PLA2-Ca* /kinetics/PLA2/PLA2-Ca*/kenz ENZYME n addmsg /kinetics/PLA2/APC /kinetics/PLA2/PLA2-Ca*/kenz SUBSTRATE n addmsg /kinetics/temp-PIP2 /kinetics/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/PLA2/PLA2-cytosolic /kinetics/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/PLA2/PIP2-PLA2* /kinetics/PLA2/PIP2-PLA2-act PRODUCT n addmsg /kinetics/PLA2/PIP2-PLA2-act /kinetics/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/PLA2/PIP2-PLA2*/kenz /kinetics/PLA2/PIP2-PLA2* REAC eA B addmsg /kinetics/PLA2/PIP2-PLA2* /kinetics/PLA2/PIP2-PLA2*/kenz ENZYME n addmsg /kinetics/PLA2/APC /kinetics/PLA2/PIP2-PLA2*/kenz SUBSTRATE n addmsg /kinetics/temp-PIP2 /kinetics/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/PLA2/PLA2-Ca* /kinetics/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/PLA2/PIP2-Ca-PLA2* /kinetics/PLA2/PIP2-Ca-PLA2-act PRODUCT n addmsg /kinetics/PLA2/PIP2-Ca-PLA2-act /kinetics/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/PLA2/PIP2-Ca-PLA2* REAC eA B addmsg /kinetics/PLA2/PIP2-Ca-PLA2* /kinetics/PLA2/PIP2-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/PLA2/APC /kinetics/PLA2/PIP2-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/DAG /kinetics/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/PLA2/PLA2-Ca* /kinetics/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/PLA2/DAG-Ca-PLA2* /kinetics/PLA2/DAG-Ca-PLA2-act PRODUCT n addmsg /kinetics/PLA2/DAG-Ca-PLA2-act /kinetics/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/PLA2/DAG-Ca-PLA2*/kenz /kinetics/PLA2/DAG-Ca-PLA2* REAC eA B addmsg /kinetics/PLA2/DAG-Ca-PLA2* /kinetics/PLA2/DAG-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/PLA2/APC /kinetics/PLA2/DAG-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/PLA2/PLA2-Ca*/kenz /kinetics/PLA2/APC REAC sA B addmsg /kinetics/PLA2/PIP2-PLA2*/kenz /kinetics/PLA2/APC REAC sA B addmsg /kinetics/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/PLA2/APC REAC sA B addmsg /kinetics/PLA2/DAG-Ca-PLA2*/kenz /kinetics/PLA2/APC REAC sA B addmsg /kinetics/PLA2/PLA2*-Ca/kenz /kinetics/PLA2/APC REAC sA B addmsg /kinetics/PLA2/Degrade-AA /kinetics/PLA2/APC REAC B A addmsg /kinetics/AA /kinetics/PLA2/Degrade-AA SUBSTRATE n addmsg /kinetics/PLA2/APC /kinetics/PLA2/Degrade-AA PRODUCT n addmsg /kinetics/PLA2/PLA2*-Ca/kenz /kinetics/PLA2/PLA2*-Ca REAC eA B addmsg /kinetics/PLA2/PLA2*-Ca-act /kinetics/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/PLA2/PLA2*-Ca /kinetics/PLA2/PLA2*-Ca/kenz ENZYME n addmsg /kinetics/PLA2/APC /kinetics/PLA2/PLA2*-Ca/kenz SUBSTRATE n addmsg /kinetics/MAPK*/MAPK* /kinetics/PLA2/PLA2* MM_PRD pA addmsg /kinetics/PLA2/PLA2*-Ca-act /kinetics/PLA2/PLA2* REAC A B addmsg /kinetics/PLA2/dephosphorylate-PLA2* /kinetics/PLA2/PLA2* REAC A B addmsg /kinetics/PLA2/PLA2* /kinetics/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/PLA2/PLA2*-Ca /kinetics/PLA2/PLA2*-Ca-act PRODUCT n addmsg /kinetics/Ca /kinetics/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/PLA2/PLA2* /kinetics/PLA2/dephosphorylate-PLA2* SUBSTRATE n addmsg /kinetics/PLA2/PLA2-cytosolic /kinetics/PLA2/dephosphorylate-PLA2* PRODUCT n addmsg /kinetics/MAPK*/MAPK* /kinetics/MAPK* REAC eA B addmsg /kinetics/MAPK*/MAPK*-feedback /kinetics/MAPK* REAC eA B addmsg /kinetics/MAPK/MAPKK*/MAPKKthr /kinetics/MAPK* MM_PRD pA addmsg /kinetics/MKP-1/MKP1-thr-deph /kinetics/MAPK* REAC sA B addmsg /kinetics/MAPK* /kinetics/MAPK*/MAPK* ENZYME n addmsg /kinetics/PLA2/PLA2-cytosolic /kinetics/MAPK*/MAPK* SUBSTRATE n addmsg /kinetics/MAPK* /kinetics/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/MAPK/craf-1* /kinetics/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/PLA2/PIP2-PLA2-act /kinetics/temp-PIP2 REAC A B addmsg /kinetics/PLA2/PIP2-Ca-PLA2-act /kinetics/temp-PIP2 REAC A B addmsg /kinetics/PLCbeta/PLC-Ca-Gq/PLCb-Ca-Gq /kinetics/IP3 MM_PRD pA addmsg /kinetics/PLCbeta/Degrade-IP3 /kinetics/IP3 REAC A B addmsg /kinetics/PLCbeta/PLC-Ca/PLC-Ca /kinetics/IP3 MM_PRD pA addmsg /kinetics/Gq/RecLigandBinding /kinetics/Glu REAC A B addmsg 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/kinetics/Gq/Trimerize-G /kinetics/G*GDP REAC A B addmsg /kinetics/Gq/mGluR /kinetics/Gq/RecLigandBinding SUBSTRATE n addmsg /kinetics/Glu /kinetics/Gq/RecLigandBinding SUBSTRATE n addmsg /kinetics/Gq/Rec-Glu /kinetics/Gq/RecLigandBinding PRODUCT n addmsg /kinetics/Gq/Trimerize-G /kinetics/Gq/G-GDP REAC B A addmsg /kinetics/Gq/Basal-Act-G /kinetics/Gq/G-GDP REAC A B addmsg /kinetics/Gq/Rec-Glu-bind-Gq /kinetics/Gq/G-GDP REAC A B addmsg /kinetics/Gq/Rec-bind-Gq /kinetics/Gq/G-GDP REAC A B addmsg /kinetics/Gq/G-GDP /kinetics/Gq/Basal-Act-G SUBSTRATE n addmsg /kinetics/G*GTP /kinetics/Gq/Basal-Act-G PRODUCT n addmsg /kinetics/BetaGamma /kinetics/Gq/Basal-Act-G PRODUCT n addmsg /kinetics/G*GDP /kinetics/Gq/Trimerize-G SUBSTRATE n addmsg /kinetics/BetaGamma /kinetics/Gq/Trimerize-G SUBSTRATE n addmsg /kinetics/Gq/G-GDP /kinetics/Gq/Trimerize-G PRODUCT n addmsg /kinetics/G*GTP /kinetics/Gq/Inact-G SUBSTRATE n addmsg /kinetics/G*GDP /kinetics/Gq/Inact-G PRODUCT n addmsg /kinetics/Gq/RecLigandBinding /kinetics/Gq/mGluR REAC A B addmsg /kinetics/Gq/Rec-Glu /kinetics/Gq/mGluR CONSERVE n nInit addmsg /kinetics/Gq/Rec-Glu-Gq /kinetics/Gq/mGluR CONSERVE n nInit addmsg /kinetics/Gq/Rec-Gq /kinetics/Gq/mGluR CONSERVE n nInit addmsg /kinetics/Gq/Rec-bind-Gq /kinetics/Gq/mGluR REAC A B addmsg /kinetics/Gq/Blocked-rec-Gq /kinetics/Gq/mGluR CONSERVE n nInit addmsg /kinetics/Gq/RecLigandBinding /kinetics/Gq/Rec-Glu REAC B A addmsg /kinetics/Gq/Rec-Glu-bind-Gq /kinetics/Gq/Rec-Glu REAC A B addmsg /kinetics/Gq/Activate-Gq /kinetics/Gq/Rec-Glu REAC B A addmsg /kinetics/Gq/Glu-bind-Rec-Gq /kinetics/Gq/Rec-Gq REAC A B addmsg /kinetics/Gq/Rec-bind-Gq /kinetics/Gq/Rec-Gq REAC B A addmsg /kinetics/Gq/Antag-bind-Rec-Gq /kinetics/Gq/Rec-Gq REAC A B addmsg /kinetics/Gq/G-GDP /kinetics/Gq/Rec-Glu-bind-Gq SUBSTRATE n addmsg /kinetics/Gq/Rec-Glu /kinetics/Gq/Rec-Glu-bind-Gq SUBSTRATE n addmsg /kinetics/Gq/Rec-Glu-Gq /kinetics/Gq/Rec-Glu-bind-Gq PRODUCT n addmsg /kinetics/Glu /kinetics/Gq/Glu-bind-Rec-Gq SUBSTRATE n addmsg /kinetics/Gq/Rec-Glu-Gq /kinetics/Gq/Glu-bind-Rec-Gq PRODUCT n addmsg /kinetics/Gq/Rec-Gq /kinetics/Gq/Glu-bind-Rec-Gq SUBSTRATE n addmsg /kinetics/Gq/Rec-Glu-bind-Gq /kinetics/Gq/Rec-Glu-Gq REAC B A addmsg /kinetics/Gq/Glu-bind-Rec-Gq /kinetics/Gq/Rec-Glu-Gq REAC B A addmsg /kinetics/Gq/Activate-Gq /kinetics/Gq/Rec-Glu-Gq REAC A B addmsg /kinetics/Gq/Rec-Glu-Gq /kinetics/Gq/Activate-Gq SUBSTRATE n addmsg /kinetics/G*GTP /kinetics/Gq/Activate-Gq PRODUCT n addmsg /kinetics/BetaGamma /kinetics/Gq/Activate-Gq PRODUCT n addmsg /kinetics/Gq/Rec-Glu /kinetics/Gq/Activate-Gq PRODUCT n addmsg /kinetics/Gq/G-GDP /kinetics/Gq/Rec-bind-Gq SUBSTRATE n addmsg /kinetics/Gq/mGluR /kinetics/Gq/Rec-bind-Gq SUBSTRATE n addmsg /kinetics/Gq/Rec-Gq /kinetics/Gq/Rec-bind-Gq PRODUCT n addmsg /kinetics/Gq/Antag-bind-Rec-Gq /kinetics/Gq/mGluRAntag REAC A B addmsg /kinetics/Gq/Rec-Gq /kinetics/Gq/Antag-bind-Rec-Gq SUBSTRATE n addmsg /kinetics/Gq/mGluRAntag /kinetics/Gq/Antag-bind-Rec-Gq SUBSTRATE n addmsg /kinetics/Gq/Blocked-rec-Gq /kinetics/Gq/Antag-bind-Rec-Gq PRODUCT n addmsg /kinetics/Gq/Antag-bind-Rec-Gq /kinetics/Gq/Blocked-rec-Gq REAC B A addmsg /kinetics/PKC-active/PKC-act-raf /kinetics/MAPK/craf-1 REAC sA B addmsg /kinetics/PPhosphatase2A/craf-deph /kinetics/MAPK/craf-1 MM_PRD pA addmsg /kinetics/PKC-active/PKC-act-raf /kinetics/MAPK/craf-1* MM_PRD pA addmsg /kinetics/MAPK*/MAPK*-feedback /kinetics/MAPK/craf-1* REAC sA B addmsg /kinetics/PPhosphatase2A/craf-deph /kinetics/MAPK/craf-1* REAC sA B addmsg /kinetics/PPhosphatase2A/craf**-deph /kinetics/MAPK/craf-1* MM_PRD pA addmsg /kinetics/Ras-act-craf /kinetics/MAPK/craf-1* REAC A B addmsg /kinetics/PPhosphatase2A/MAPKK-deph-ser /kinetics/MAPK/MAPKK MM_PRD pA addmsg /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.1 /kinetics/MAPK/MAPKK REAC sA B addmsg /kinetics/MAPK/MAPKK*/MAPKKtyr /kinetics/MAPK/MAPK REAC sA B addmsg /kinetics/MKP-1/MKP1-tyr-deph /kinetics/MAPK/MAPK MM_PRD pA addmsg /kinetics/MAPK*/MAPK*-feedback /kinetics/MAPK/craf-1** MM_PRD pA addmsg /kinetics/PPhosphatase2A/craf**-deph /kinetics/MAPK/craf-1** REAC sA B addmsg /kinetics/MAPK/MAPKK*/MAPKKtyr /kinetics/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/MAPK/MAPKK*/MAPKKthr /kinetics/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/MKP-1/MKP1-tyr-deph /kinetics/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/MKP-1/MKP1-thr-deph /kinetics/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/MAPK/MAPKK*/MAPKKtyr /kinetics/MAPK/MAPKK* REAC eA B addmsg /kinetics/MAPK/MAPKK*/MAPKKthr /kinetics/MAPK/MAPKK* REAC eA B addmsg /kinetics/PPhosphatase2A/MAPKK-deph /kinetics/MAPK/MAPKK* REAC sA B addmsg /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.2 /kinetics/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/MAPK/MAPKK* /kinetics/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/MAPK/MAPK /kinetics/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/MAPK/MAPKK* /kinetics/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/MAPK/MAPK-tyr /kinetics/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/PPhosphatase2A/MAPKK-deph /kinetics/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/PPhosphatase2A/MAPKK-deph-ser /kinetics/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.1 /kinetics/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.2 /kinetics/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/Ras-act-craf /kinetics/MAPK/Raf-GTP-Ras* REAC B A addmsg /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.1 /kinetics/MAPK/Raf-GTP-Ras* REAC eA B addmsg /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.2 /kinetics/MAPK/Raf-GTP-Ras* REAC eA B addmsg /kinetics/MAPK/Raf-GTP-Ras* /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.1 ENZYME n addmsg /kinetics/MAPK/MAPKK /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.1 SUBSTRATE n addmsg /kinetics/MAPK/Raf-GTP-Ras* /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.2 ENZYME n addmsg /kinetics/MAPK/MAPKK-ser /kinetics/MAPK/Raf-GTP-Ras*/Raf-GTP-Ras*.2 SUBSTRATE n addmsg /kinetics/MKP-1/MKP1-tyr-deph /kinetics/MKP-1 REAC eA B addmsg /kinetics/MKP-1/MKP1-thr-deph /kinetics/MKP-1 REAC eA B addmsg /kinetics/MKP-1 /kinetics/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/MAPK/MAPK-tyr /kinetics/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/MKP-1 /kinetics/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/MAPK* /kinetics/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/MAPK/Raf-GTP-Ras* /kinetics/Ras-act-craf PRODUCT n addmsg /kinetics/MAPK/craf-1* /kinetics/Ras-act-craf SUBSTRATE n addmsg /kinetics/Ras/GTP-Ras /kinetics/Ras-act-craf SUBSTRATE n addmsg /kinetics/PPhosphatase2A/craf-deph /kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/PPhosphatase2A/MAPKK-deph /kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/PPhosphatase2A/MAPKK-deph-ser /kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/PPhosphatase2A/craf**-deph /kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/MAPK/craf-1* /kinetics/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/MAPK/MAPKK* /kinetics/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/MAPK/MAPKK-ser /kinetics/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/MAPK/craf-1** /kinetics/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/BetaGamma /kinetics/Ras/bg-act-GEF SUBSTRATE n addmsg /kinetics/Ras/inact-GEF /kinetics/Ras/bg-act-GEF SUBSTRATE n addmsg /kinetics/Ras/GEF-Gprot-bg /kinetics/Ras/bg-act-GEF PRODUCT n addmsg /kinetics/Ras/GEF-Gprot-bg/GEF-bg_act-ras /kinetics/Ras/GEF-Gprot-bg REAC eA B addmsg /kinetics/Ras/bg-act-GEF /kinetics/Ras/GEF-Gprot-bg REAC B A addmsg /kinetics/Ras/GEF-Gprot-bg /kinetics/Ras/GEF-Gprot-bg/GEF-bg_act-ras ENZYME n addmsg /kinetics/Ras/GDP-Ras /kinetics/Ras/GEF-Gprot-bg/GEF-bg_act-ras SUBSTRATE n addmsg /kinetics/Ras/GEF* /kinetics/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/Ras/inact-GEF /kinetics/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/Ras/bg-act-GEF /kinetics/Ras/inact-GEF REAC A B addmsg /kinetics/PKC-active/PKC-act-GEF /kinetics/Ras/inact-GEF REAC sA B addmsg /kinetics/Ras/dephosph-GEF /kinetics/Ras/inact-GEF REAC B A addmsg /kinetics/PKA-active/PKA-phosph-GEF /kinetics/Ras/inact-GEF REAC sA B addmsg /kinetics/Ras/CaM-bind-GEF /kinetics/Ras/inact-GEF REAC A B addmsg /kinetics/Ras/dephosph-inact-GEF* /kinetics/Ras/inact-GEF REAC B A addmsg /kinetics/PKC-active/PKC-act-GEF /kinetics/Ras/GEF* MM_PRD pA addmsg /kinetics/Ras/dephosph-GEF /kinetics/Ras/GEF* REAC A B addmsg /kinetics/Ras/GEF*/GEF*-act-ras /kinetics/Ras/GEF* REAC eA B addmsg /kinetics/Ras/GEF* /kinetics/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/Ras/GDP-Ras /kinetics/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/Ras/GEF-Gprot-bg/GEF-bg_act-ras /kinetics/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/Ras/GAP/GAP-inact-ras /kinetics/Ras/GTP-Ras REAC sA B addmsg /kinetics/Ras/Ras-intrinsic-GTPase /kinetics/Ras/GTP-Ras REAC A B addmsg /kinetics/Ras/GEF*/GEF*-act-ras /kinetics/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/Ras-act-craf /kinetics/Ras/GTP-Ras REAC A B addmsg /kinetics/Ras/GEF-Gprot-bg/GEF-bg_act-ras /kinetics/Ras/GDP-Ras REAC sA B addmsg /kinetics/Ras/GAP/GAP-inact-ras /kinetics/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/Ras/Ras-intrinsic-GTPase /kinetics/Ras/GDP-Ras REAC B A addmsg /kinetics/Ras/GEF*/GEF*-act-ras /kinetics/Ras/GDP-Ras REAC sA B addmsg /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/Ras/GDP-Ras REAC sA B addmsg /kinetics/Ras/GTP-Ras /kinetics/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/Ras/GDP-Ras /kinetics/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/Ras/GAP* /kinetics/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/Ras/GAP /kinetics/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/PKC-active/PKC-inact-GAP /kinetics/Ras/GAP* MM_PRD pA addmsg /kinetics/Ras/dephosph-GAP /kinetics/Ras/GAP* REAC A B addmsg /kinetics/Ras/GAP/GAP-inact-ras /kinetics/Ras/GAP REAC eA B addmsg /kinetics/PKC-active/PKC-inact-GAP /kinetics/Ras/GAP REAC sA B addmsg /kinetics/Ras/dephosph-GAP /kinetics/Ras/GAP REAC B A addmsg /kinetics/Ras/GAP /kinetics/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/Ras/GTP-Ras /kinetics/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/PKA-active/PKA-phosph-GEF /kinetics/Ras/inact-GEF* MM_PRD pA addmsg /kinetics/Ras/dephosph-inact-GEF* /kinetics/Ras/inact-GEF* REAC A B addmsg /kinetics/Ras/inact-GEF /kinetics/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/Ras/CaM-GEF /kinetics/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/CaM-Ca4 /kinetics/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/Ras/CaM-bind-GEF /kinetics/Ras/CaM-GEF REAC B A addmsg /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/Ras/CaM-GEF REAC eA B addmsg /kinetics/Ras/CaM-GEF /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/Ras/GDP-Ras /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/Ras/inact-GEF* /kinetics/Ras/dephosph-inact-GEF* SUBSTRATE n addmsg /kinetics/Ras/inact-GEF /kinetics/Ras/dephosph-inact-GEF* PRODUCT n addmsg /kinetics/PKA-active/PKA-phosph-GEF /kinetics/PKA-active REAC eA B addmsg /kinetics/PKA-active/PKA-phosph-I1 /kinetics/PKA-active REAC eA B addmsg /kinetics/PKA/Release-C1 /kinetics/PKA-active REAC B A addmsg /kinetics/PKA/Release-C2 /kinetics/PKA-active REAC B A addmsg /kinetics/PKA/inhib-PKA /kinetics/PKA-active REAC A B addmsg /kinetics/PKA-active/PKA-phosph-GAP /kinetics/PKA-active REAC eA B addmsg /kinetics/PKA-active/phosph-PDE /kinetics/PKA-active REAC eA B addmsg /kinetics/PKA-active /kinetics/PKA-active/PKA-phosph-GEF ENZYME n addmsg /kinetics/Ras/inact-GEF /kinetics/PKA-active/PKA-phosph-GEF SUBSTRATE n addmsg /kinetics/PKA-active /kinetics/PKA-active/PKA-phosph-I1 ENZYME n addmsg /kinetics/PP1/I1 /kinetics/PKA-active/PKA-phosph-I1 SUBSTRATE n addmsg /kinetics/PKA-active /kinetics/PKA-active/PKA-phosph-GAP ENZYME n addmsg /kinetics/PKA-active /kinetics/PKA-active/phosph-PDE ENZYME n addmsg /kinetics/AC/cAMP-PDE /kinetics/PKA-active/phosph-PDE SUBSTRATE n addmsg /kinetics/Ras/CaM-bind-GEF /kinetics/CaM-Ca4 REAC A B addmsg /kinetics/CaMKII/CaMKII-bind-CaM /kinetics/CaM-Ca4 REAC A B addmsg /kinetics/CaMKII/CaMK-thr286-bind-CaM /kinetics/CaM-Ca4 REAC A B addmsg /kinetics/CaM/CaM-Ca3-bind-Ca /kinetics/CaM-Ca4 REAC B A addmsg /kinetics/PP2B/CaMCa4-bind-CaNAB /kinetics/CaM-Ca4 REAC A B addmsg /kinetics/AC/CaM-bind-AC1 /kinetics/CaM-Ca4 REAC A B addmsg /kinetics/AC/CaM_bind_PDE1 /kinetics/CaM-Ca4 REAC A B addmsg /kinetics/CaMKII/CaMKII-bind-CaM /kinetics/CaMKII/CaMKII REAC A B addmsg /kinetics/PP1-active/Deph-thr306 /kinetics/CaMKII/CaMKII MM_PRD pA addmsg /kinetics/PP1-active/Deph_thr286b /kinetics/CaMKII/CaMKII MM_PRD pA addmsg /kinetics/CaMKII/basal-activity /kinetics/CaMKII/CaMKII REAC A B addmsg /kinetics/CaMKII/CaMKII-bind-CaM /kinetics/CaMKII/CaMKII-CaM REAC B A addmsg /kinetics/PP1-active/Deph-thr286 /kinetics/CaMKII/CaMKII-CaM MM_PRD pA addmsg /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_286 /kinetics/CaMKII/CaMKII-CaM REAC sA B addmsg /kinetics/CaMKII/tot_autonomous_CaMKII/auton_286 /kinetics/CaMKII/CaMKII-CaM REAC sA B addmsg /kinetics/CaMKII/CaMK-thr286-bind-CaM /kinetics/CaMKII/CaMKII-thr286*-CaM REAC B A addmsg /kinetics/PP1-active/Deph-thr286 /kinetics/CaMKII/CaMKII-thr286*-CaM REAC sA B addmsg /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_286 /kinetics/CaMKII/CaMKII-thr286*-CaM MM_PRD pA addmsg /kinetics/CaMKII/tot_autonomous_CaMKII/auton_286 /kinetics/CaMKII/CaMKII-thr286*-CaM MM_PRD pA addmsg /kinetics/PP1-active/Deph-thr305 /kinetics/CaMKII/CaMKII*** REAC sA B addmsg /kinetics/PP1-active/Deph-thr286c /kinetics/CaMKII/CaMKII*** REAC sA B addmsg /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_305 /kinetics/CaMKII/CaMKII*** MM_PRD pA addmsg /kinetics/CaMKII/tot_autonomous_CaMKII/auton_305 /kinetics/CaMKII/CaMKII*** MM_PRD pA addmsg /kinetics/CaM-Ca4 /kinetics/CaMKII/CaMKII-bind-CaM SUBSTRATE n addmsg /kinetics/CaMKII/CaMKII /kinetics/CaMKII/CaMKII-bind-CaM SUBSTRATE n addmsg /kinetics/CaMKII/CaMKII-CaM /kinetics/CaMKII/CaMKII-bind-CaM PRODUCT n addmsg /kinetics/CaMKII/CaMKII-thr286 /kinetics/CaMKII/CaMK-thr286-bind-CaM SUBSTRATE n addmsg /kinetics/CaM-Ca4 /kinetics/CaMKII/CaMK-thr286-bind-CaM SUBSTRATE n addmsg /kinetics/CaMKII/CaMKII-thr286*-CaM /kinetics/CaMKII/CaMK-thr286-bind-CaM PRODUCT n addmsg /kinetics/CaMKII/CaMK-thr286-bind-CaM /kinetics/CaMKII/CaMKII-thr286 REAC A B addmsg /kinetics/PP1-active/Deph-thr305 /kinetics/CaMKII/CaMKII-thr286 MM_PRD pA addmsg /kinetics/PP1-active/Deph_thr286b /kinetics/CaMKII/CaMKII-thr286 REAC sA B addmsg /kinetics/CaMKII/basal-activity /kinetics/CaMKII/CaMKII-thr286 REAC B A addmsg /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_305 /kinetics/CaMKII/CaMKII-thr286 REAC sA B addmsg /kinetics/CaMKII/tot_autonomous_CaMKII/auton_305 /kinetics/CaMKII/CaMKII-thr286 REAC sA B addmsg /kinetics/PP1-active/Deph-thr306 /kinetics/CaMKII/CaMK-thr306 REAC sA B addmsg /kinetics/PP1-active/Deph-thr286c /kinetics/CaMKII/CaMK-thr306 MM_PRD pA addmsg /kinetics/CaMKII/CaMKII /kinetics/CaMKII/basal-activity SUBSTRATE n addmsg /kinetics/CaMKII/CaMKII-thr286 /kinetics/CaMKII/basal-activity PRODUCT n addmsg /kinetics/CaMKII/CaMKII-CaM /kinetics/CaMKII/tot_CaM_CaMKII SUMTOTAL n nInit addmsg /kinetics/CaMKII/CaMKII-thr286*-CaM /kinetics/CaMKII/tot_CaM_CaMKII SUMTOTAL n nInit addmsg /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_305 /kinetics/CaMKII/tot_CaM_CaMKII REAC eA B addmsg /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_286 /kinetics/CaMKII/tot_CaM_CaMKII REAC eA B addmsg /kinetics/CaMKII/tot_CaM_CaMKII /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_305 ENZYME n addmsg /kinetics/CaMKII/CaMKII-thr286 /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_305 SUBSTRATE n addmsg /kinetics/CaMKII/total-CaMKII /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_305 INTRAMOL n addmsg /kinetics/CaMKII/tot_CaM_CaMKII /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_286 ENZYME n addmsg /kinetics/CaMKII/CaMKII-CaM /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_286 SUBSTRATE n addmsg /kinetics/CaMKII/total-CaMKII /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_286 INTRAMOL n addmsg /kinetics/CaMKII/CaMKII-thr286 /kinetics/CaMKII/tot_autonomous_CaMKII SUMTOTAL n nInit addmsg /kinetics/CaMKII/CaMKII*** /kinetics/CaMKII/tot_autonomous_CaMKII SUMTOTAL n nInit addmsg /kinetics/CaMKII/tot_autonomous_CaMKII/auton_305 /kinetics/CaMKII/tot_autonomous_CaMKII REAC eA B addmsg /kinetics/CaMKII/tot_autonomous_CaMKII/auton_286 /kinetics/CaMKII/tot_autonomous_CaMKII REAC eA B addmsg /kinetics/CaMKII/tot_autonomous_CaMKII /kinetics/CaMKII/tot_autonomous_CaMKII/auton_305 ENZYME n addmsg /kinetics/CaMKII/CaMKII-thr286 /kinetics/CaMKII/tot_autonomous_CaMKII/auton_305 SUBSTRATE n addmsg /kinetics/CaMKII/total-CaMKII /kinetics/CaMKII/tot_autonomous_CaMKII/auton_305 INTRAMOL n addmsg /kinetics/CaMKII/tot_autonomous_CaMKII /kinetics/CaMKII/tot_autonomous_CaMKII/auton_286 ENZYME n addmsg /kinetics/CaMKII/CaMKII-CaM /kinetics/CaMKII/tot_autonomous_CaMKII/auton_286 SUBSTRATE n addmsg /kinetics/CaMKII/total-CaMKII /kinetics/CaMKII/tot_autonomous_CaMKII/auton_286 INTRAMOL n addmsg /kinetics/PP1-active/Deph-thr286 /kinetics/PP1-active REAC eA B addmsg /kinetics/PP1-active/Deph-thr305 /kinetics/PP1-active REAC eA B addmsg /kinetics/PP1-active/Deph-thr306 /kinetics/PP1-active REAC eA B addmsg /kinetics/PP1-active/Deph_thr286b /kinetics/PP1-active REAC eA B addmsg /kinetics/PP1-active/Deph-thr286c /kinetics/PP1-active REAC eA B addmsg /kinetics/PP1/Inact-PP1 /kinetics/PP1-active REAC A B addmsg /kinetics/PP1/dissoc-PP1-I1 /kinetics/PP1-active REAC B A addmsg /kinetics/PP1-active /kinetics/PP1-active/Deph-thr286 ENZYME n addmsg /kinetics/CaMKII/CaMKII-thr286*-CaM /kinetics/PP1-active/Deph-thr286 SUBSTRATE n addmsg /kinetics/PP1-active /kinetics/PP1-active/Deph-thr305 ENZYME n addmsg /kinetics/CaMKII/CaMKII*** /kinetics/PP1-active/Deph-thr305 SUBSTRATE n addmsg /kinetics/PP1-active /kinetics/PP1-active/Deph-thr306 ENZYME n addmsg /kinetics/CaMKII/CaMK-thr306 /kinetics/PP1-active/Deph-thr306 SUBSTRATE n addmsg /kinetics/PP1-active /kinetics/PP1-active/Deph-thr286c ENZYME n addmsg /kinetics/CaMKII/CaMKII*** /kinetics/PP1-active/Deph-thr286c SUBSTRATE n addmsg /kinetics/PP1-active /kinetics/PP1-active/Deph_thr286b ENZYME n addmsg /kinetics/CaMKII/CaMKII-thr286 /kinetics/PP1-active/Deph_thr286b SUBSTRATE n addmsg /kinetics/CaM/CaM-TR2-bind-Ca /kinetics/CaM/CaM REAC A B addmsg /kinetics/CaM/neurogranin-bind-CaM /kinetics/CaM/CaM REAC A B addmsg /kinetics/PKC-active/PKC-phosph-ng-CaM /kinetics/CaM/CaM MM_PRD pA addmsg /kinetics/CaM/CaM /kinetics/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/CaM-TR2-Ca2 /kinetics/CaM/CaM-TR2-bind-Ca PRODUCT n addmsg /kinetics/Ca /kinetics/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/Ca /kinetics/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/CaM-TR2-Ca2 /kinetics/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/Ca /kinetics/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/CaM-Ca3 /kinetics/CaM/CaM-TR2-Ca2-bind-Ca PRODUCT n addmsg /kinetics/CaM-Ca3 /kinetics/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/Ca /kinetics/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/CaM-Ca4 /kinetics/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/CaM/neurogranin-bind-CaM /kinetics/CaM/neurogranin-CaM REAC B A addmsg /kinetics/PKC-active/PKC-phosph-ng-CaM /kinetics/CaM/neurogranin-CaM REAC sA B addmsg /kinetics/CaM/neurogranin /kinetics/CaM/neurogranin-bind-CaM SUBSTRATE n addmsg /kinetics/CaM/neurogranin-CaM /kinetics/CaM/neurogranin-bind-CaM PRODUCT n addmsg /kinetics/CaM/CaM /kinetics/CaM/neurogranin-bind-CaM SUBSTRATE n addmsg /kinetics/CaM(Ca)n-CaNAB/dephosph_neurogranin /kinetics/CaM/neurogranin* REAC sA B addmsg /kinetics/PKC-active/PKC-phosph-neurogranin /kinetics/CaM/neurogranin* MM_PRD pA addmsg /kinetics/PKC-active/PKC-phosph-ng-CaM /kinetics/CaM/neurogranin* MM_PRD pA addmsg /kinetics/CaM/dephosph-neurogranin /kinetics/CaM/neurogranin* REAC A B addmsg /kinetics/CaM(Ca)n-CaNAB/dephosph_neurogranin /kinetics/CaM/neurogranin MM_PRD pA addmsg /kinetics/CaM/neurogranin-bind-CaM /kinetics/CaM/neurogranin REAC A B addmsg /kinetics/PKC-active/PKC-phosph-neurogranin /kinetics/CaM/neurogranin REAC sA B addmsg /kinetics/CaM/dephosph-neurogranin /kinetics/CaM/neurogranin REAC B A addmsg /kinetics/CaM/neurogranin* /kinetics/CaM/dephosph-neurogranin SUBSTRATE n addmsg /kinetics/CaM/neurogranin /kinetics/CaM/dephosph-neurogranin PRODUCT n addmsg /kinetics/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/CaM-Ca3 REAC B A addmsg /kinetics/CaM/CaM-Ca3-bind-Ca /kinetics/CaM-Ca3 REAC A B addmsg /kinetics/PP2B/CaMCa3-bind-CaNAB /kinetics/CaM-Ca3 REAC A B addmsg /kinetics/CaM/CaM-TR2-bind-Ca /kinetics/CaM-TR2-Ca2 REAC B A addmsg /kinetics/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/CaM-TR2-Ca2 REAC A B addmsg /kinetics/PP2B/CaM-Ca2-bind-CaNAB /kinetics/CaM-TR2-Ca2 REAC A B addmsg /kinetics/CaM(Ca)n-CaNAB/dephosph_neurogranin /kinetics/CaM(Ca)n-CaNAB REAC eA B addmsg /kinetics/CaM(Ca)n-CaNAB/dephosph_inhib1 /kinetics/CaM(Ca)n-CaNAB REAC eA B addmsg /kinetics/CaM(Ca)n-CaNAB/dephosph-PP1-I* /kinetics/CaM(Ca)n-CaNAB REAC eA B addmsg /kinetics/PP2B/CaMCa4-CaNAB /kinetics/CaM(Ca)n-CaNAB SUMTOTAL n nInit addmsg /kinetics/PP2B/CaMCa3-CaNAB /kinetics/CaM(Ca)n-CaNAB SUMTOTAL n nInit addmsg /kinetics/PP2B/CaMCa2-CANAB /kinetics/CaM(Ca)n-CaNAB SUMTOTAL n nInit addmsg /kinetics/CaM(Ca)n-CaNAB /kinetics/CaM(Ca)n-CaNAB/dephosph_neurogranin ENZYME n addmsg /kinetics/CaM/neurogranin* /kinetics/CaM(Ca)n-CaNAB/dephosph_neurogranin SUBSTRATE n addmsg /kinetics/CaM(Ca)n-CaNAB /kinetics/CaM(Ca)n-CaNAB/dephosph_inhib1 ENZYME n addmsg /kinetics/PP1/I1* /kinetics/CaM(Ca)n-CaNAB/dephosph_inhib1 SUBSTRATE n addmsg /kinetics/CaM(Ca)n-CaNAB /kinetics/CaM(Ca)n-CaNAB/dephosph-PP1-I* ENZYME n addmsg /kinetics/PP1/PP1-I1* /kinetics/CaM(Ca)n-CaNAB/dephosph-PP1-I* SUBSTRATE n addmsg /kinetics/PKA-active/PKA-phosph-I1 /kinetics/PP1/I1 REAC sA B addmsg /kinetics/CaNAB-Ca4/dephosph_inhib1_noCaM /kinetics/PP1/I1 MM_PRD pA addmsg /kinetics/CaM(Ca)n-CaNAB/dephosph_inhib1 /kinetics/PP1/I1 MM_PRD pA addmsg /kinetics/PP2A/PP2A-dephosph-I1 /kinetics/PP1/I1 MM_PRD pA addmsg /kinetics/PP1/dissoc-PP1-I1 /kinetics/PP1/I1 REAC B A addmsg /kinetics/PP1/Inact-PP1 /kinetics/PP1/I1* REAC A B addmsg /kinetics/PKA-active/PKA-phosph-I1 /kinetics/PP1/I1* MM_PRD pA addmsg /kinetics/CaNAB-Ca4/dephosph_inhib1_noCaM /kinetics/PP1/I1* REAC sA B addmsg /kinetics/CaM(Ca)n-CaNAB/dephosph_inhib1 /kinetics/PP1/I1* REAC sA B addmsg /kinetics/PP2A/PP2A-dephosph-I1 /kinetics/PP1/I1* REAC sA B addmsg /kinetics/PP1/PP1-I1* /kinetics/PP1/Inact-PP1 PRODUCT n addmsg /kinetics/PP1/I1* /kinetics/PP1/Inact-PP1 SUBSTRATE n addmsg /kinetics/PP1-active /kinetics/PP1/Inact-PP1 SUBSTRATE n addmsg /kinetics/PP1/Inact-PP1 /kinetics/PP1/PP1-I1* REAC B A addmsg /kinetics/PP2A/PP2A-dephosph-PP1-I* /kinetics/PP1/PP1-I1* REAC sA B addmsg /kinetics/CaM(Ca)n-CaNAB/dephosph-PP1-I* /kinetics/PP1/PP1-I1* REAC sA B addmsg /kinetics/PP1/dissoc-PP1-I1 /kinetics/PP1/PP1-I1 REAC A B addmsg /kinetics/PP2A/PP2A-dephosph-PP1-I* /kinetics/PP1/PP1-I1 MM_PRD pA addmsg /kinetics/CaM(Ca)n-CaNAB/dephosph-PP1-I* /kinetics/PP1/PP1-I1 MM_PRD pA addmsg /kinetics/PP1/PP1-I1 /kinetics/PP1/dissoc-PP1-I1 SUBSTRATE n addmsg /kinetics/PP1-active /kinetics/PP1/dissoc-PP1-I1 PRODUCT n addmsg /kinetics/PP1/I1 /kinetics/PP1/dissoc-PP1-I1 PRODUCT n addmsg /kinetics/PP2A/PP2A-dephosph-I1 /kinetics/PP2A REAC eA B addmsg /kinetics/PP2A/PP2A-dephosph-PP1-I* /kinetics/PP2A REAC eA B addmsg /kinetics/PP2A /kinetics/PP2A/PP2A-dephosph-I1 ENZYME n addmsg /kinetics/PP1/I1* /kinetics/PP2A/PP2A-dephosph-I1 SUBSTRATE n addmsg /kinetics/PP2A /kinetics/PP2A/PP2A-dephosph-PP1-I* ENZYME n addmsg /kinetics/PP1/PP1-I1* /kinetics/PP2A/PP2A-dephosph-PP1-I* SUBSTRATE n addmsg /kinetics/CaNAB-Ca4/dephosph_inhib1_noCaM /kinetics/CaNAB-Ca4 REAC eA B addmsg /kinetics/PP2B/Ca-bind-CaNAB-Ca2 /kinetics/CaNAB-Ca4 REAC B A addmsg /kinetics/PP2B/CaM-Ca2-bind-CaNAB /kinetics/CaNAB-Ca4 REAC A B addmsg /kinetics/PP2B/CaMCa4-bind-CaNAB /kinetics/CaNAB-Ca4 REAC A B addmsg /kinetics/PP2B/CaMCa3-bind-CaNAB /kinetics/CaNAB-Ca4 REAC A B addmsg /kinetics/CaNAB-Ca4 /kinetics/CaNAB-Ca4/dephosph_inhib1_noCaM ENZYME n addmsg /kinetics/PP1/I1* /kinetics/CaNAB-Ca4/dephosph_inhib1_noCaM SUBSTRATE n addmsg /kinetics/PP2B/Ca-bind-CaNAB /kinetics/PP2B/CaNAB REAC A B addmsg /kinetics/PP2B/Ca-bind-CaNAB /kinetics/PP2B/CaNAB-Ca2 REAC B A addmsg /kinetics/PP2B/Ca-bind-CaNAB-Ca2 /kinetics/PP2B/CaNAB-Ca2 REAC A B addmsg /kinetics/CaNAB-Ca4 /kinetics/PP2B/Ca-bind-CaNAB-Ca2 PRODUCT n addmsg /kinetics/Ca /kinetics/PP2B/Ca-bind-CaNAB-Ca2 SUBSTRATE n addmsg /kinetics/Ca /kinetics/PP2B/Ca-bind-CaNAB-Ca2 SUBSTRATE n addmsg /kinetics/PP2B/CaNAB-Ca2 /kinetics/PP2B/Ca-bind-CaNAB-Ca2 SUBSTRATE n addmsg /kinetics/PP2B/CaNAB /kinetics/PP2B/Ca-bind-CaNAB SUBSTRATE n addmsg /kinetics/PP2B/CaNAB-Ca2 /kinetics/PP2B/Ca-bind-CaNAB PRODUCT n addmsg /kinetics/Ca /kinetics/PP2B/Ca-bind-CaNAB SUBSTRATE n addmsg /kinetics/Ca /kinetics/PP2B/Ca-bind-CaNAB SUBSTRATE n addmsg /kinetics/CaNAB-Ca4 /kinetics/PP2B/CaM-Ca2-bind-CaNAB SUBSTRATE n addmsg /kinetics/CaM-TR2-Ca2 /kinetics/PP2B/CaM-Ca2-bind-CaNAB SUBSTRATE n addmsg /kinetics/PP2B/CaMCa2-CANAB /kinetics/PP2B/CaM-Ca2-bind-CaNAB PRODUCT n addmsg /kinetics/PP2B/CaMCa3-bind-CaNAB /kinetics/PP2B/CaMCa3-CaNAB REAC B A addmsg /kinetics/PP2B/CaM-Ca2-bind-CaNAB /kinetics/PP2B/CaMCa2-CANAB REAC B A addmsg /kinetics/PP2B/CaMCa4-bind-CaNAB /kinetics/PP2B/CaMCa4-CaNAB REAC B A addmsg /kinetics/PP2B/CaMCa3-CaNAB /kinetics/PP2B/CaMCa3-bind-CaNAB PRODUCT n addmsg /kinetics/CaM-Ca3 /kinetics/PP2B/CaMCa3-bind-CaNAB SUBSTRATE n addmsg /kinetics/CaNAB-Ca4 /kinetics/PP2B/CaMCa3-bind-CaNAB SUBSTRATE n addmsg /kinetics/PP2B/CaMCa4-CaNAB /kinetics/PP2B/CaMCa4-bind-CaNAB PRODUCT n addmsg /kinetics/CaM-Ca4 /kinetics/PP2B/CaMCa4-bind-CaNAB SUBSTRATE n addmsg /kinetics/CaNAB-Ca4 /kinetics/PP2B/CaMCa4-bind-CaNAB SUBSTRATE n addmsg /kinetics/PKA/cAMP-bind-site-B1 /kinetics/PKA/R2C2 REAC A B addmsg /kinetics/PKA/cAMP-bind-site-B1 /kinetics/PKA/R2C2-cAMP REAC B A addmsg /kinetics/PKA/cAMP-bind-site-B2 /kinetics/PKA/R2C2-cAMP REAC A B addmsg /kinetics/PKA/R2C2 /kinetics/PKA/cAMP-bind-site-B1 SUBSTRATE n addmsg /kinetics/PKA/R2C2-cAMP /kinetics/PKA/cAMP-bind-site-B1 PRODUCT n addmsg /kinetics/cAMP /kinetics/PKA/cAMP-bind-site-B1 SUBSTRATE n addmsg /kinetics/PKA/R2C2-cAMP /kinetics/PKA/cAMP-bind-site-B2 SUBSTRATE n addmsg /kinetics/cAMP /kinetics/PKA/cAMP-bind-site-B2 SUBSTRATE n addmsg /kinetics/PKA/R2C2-cAMP2 /kinetics/PKA/cAMP-bind-site-B2 PRODUCT n addmsg /kinetics/PKA/R2C2-cAMP2 /kinetics/PKA/cAMP-bind-site-A1 SUBSTRATE n addmsg /kinetics/cAMP /kinetics/PKA/cAMP-bind-site-A1 SUBSTRATE n addmsg /kinetics/PKA/R2C2-cAMP3 /kinetics/PKA/cAMP-bind-site-A1 PRODUCT n addmsg /kinetics/cAMP /kinetics/PKA/cAMP-bind-site-A2 SUBSTRATE n addmsg /kinetics/PKA/R2C2-cAMP3 /kinetics/PKA/cAMP-bind-site-A2 SUBSTRATE n addmsg /kinetics/PKA/R2C2-cAMP4 /kinetics/PKA/cAMP-bind-site-A2 PRODUCT n addmsg /kinetics/PKA/cAMP-bind-site-B2 /kinetics/PKA/R2C2-cAMP2 REAC B A addmsg /kinetics/PKA/cAMP-bind-site-A1 /kinetics/PKA/R2C2-cAMP2 REAC A B addmsg /kinetics/PKA/cAMP-bind-site-A1 /kinetics/PKA/R2C2-cAMP3 REAC B A addmsg /kinetics/PKA/cAMP-bind-site-A2 /kinetics/PKA/R2C2-cAMP3 REAC A B addmsg /kinetics/PKA/cAMP-bind-site-A2 /kinetics/PKA/R2C2-cAMP4 REAC B A addmsg /kinetics/PKA/Release-C1 /kinetics/PKA/R2C2-cAMP4 REAC A B addmsg /kinetics/PKA/Release-C1 /kinetics/PKA/R2C-cAMP4 REAC B A addmsg /kinetics/PKA/Release-C2 /kinetics/PKA/R2C-cAMP4 REAC A B addmsg /kinetics/PKA/Release-C2 /kinetics/PKA/R2-cAMP4 REAC B A addmsg /kinetics/PKA/R2C2-cAMP4 /kinetics/PKA/Release-C1 SUBSTRATE n addmsg /kinetics/PKA-active /kinetics/PKA/Release-C1 PRODUCT n addmsg /kinetics/PKA/R2C-cAMP4 /kinetics/PKA/Release-C1 PRODUCT n addmsg /kinetics/PKA/R2C-cAMP4 /kinetics/PKA/Release-C2 SUBSTRATE n addmsg /kinetics/PKA-active /kinetics/PKA/Release-C2 PRODUCT n addmsg /kinetics/PKA/R2-cAMP4 /kinetics/PKA/Release-C2 PRODUCT n addmsg /kinetics/PKA/inhib-PKA /kinetics/PKA/PKA-inhibitor REAC A B addmsg /kinetics/PKA-active /kinetics/PKA/inhib-PKA SUBSTRATE n addmsg /kinetics/PKA/PKA-inhibitor /kinetics/PKA/inhib-PKA SUBSTRATE n addmsg /kinetics/PKA/inhibited-PKA /kinetics/PKA/inhib-PKA PRODUCT n addmsg /kinetics/PKA/inhib-PKA /kinetics/PKA/inhibited-PKA REAC B A addmsg /kinetics/PKA/cAMP-bind-site-B1 /kinetics/cAMP REAC A B addmsg /kinetics/PKA/cAMP-bind-site-B2 /kinetics/cAMP REAC A B addmsg /kinetics/PKA/cAMP-bind-site-A1 /kinetics/cAMP REAC A B addmsg /kinetics/PKA/cAMP-bind-site-A2 /kinetics/cAMP REAC A B addmsg /kinetics/AC/AC2*/kenz /kinetics/cAMP MM_PRD pA addmsg /kinetics/AC/AC2-Gs/kenz /kinetics/cAMP MM_PRD pA addmsg /kinetics/AC/AC1-CaM/kenz /kinetics/cAMP MM_PRD pA addmsg /kinetics/AC/AC1-Gs/kenz /kinetics/cAMP MM_PRD pA addmsg /kinetics/AC/AC2*-Gs/kenz /kinetics/cAMP MM_PRD pA addmsg /kinetics/AC/cAMP-PDE*/PDE* /kinetics/cAMP REAC sA B addmsg /kinetics/AC/cAMP-PDE/PDE /kinetics/cAMP REAC sA B addmsg /kinetics/AC/PDE1/PDE1 /kinetics/cAMP REAC sA B addmsg /kinetics/AC/CaM.PDE1/CaM.PDE1 /kinetics/cAMP REAC sA B addmsg /kinetics/AC/AC2*/kenz /kinetics/AC/ATP REAC sA B addmsg /kinetics/AC/AC2-Gs/kenz /kinetics/AC/ATP REAC sA B addmsg /kinetics/AC/AC1-CaM/kenz /kinetics/AC/ATP REAC sA B addmsg /kinetics/AC/AC1-Gs/kenz /kinetics/AC/ATP REAC sA B addmsg /kinetics/AC/AC2*-Gs/kenz /kinetics/AC/ATP REAC sA B addmsg /kinetics/AC/CaM-bind-AC1 /kinetics/AC/AC1-CaM REAC B A addmsg /kinetics/AC/AC1-CaM /kinetics/AC/AC1-CaM/kenz ENZYME n addmsg /kinetics/AC/ATP /kinetics/AC/AC1-CaM/kenz SUBSTRATE n addmsg /kinetics/AC/CaM-bind-AC1 /kinetics/AC/AC1 REAC A B addmsg /kinetics/AC/Gs-bind-AC1 /kinetics/AC/AC1 REAC A B addmsg /kinetics/CaM-Ca4 /kinetics/AC/CaM-bind-AC1 SUBSTRATE n addmsg /kinetics/AC/AC1-CaM /kinetics/AC/CaM-bind-AC1 PRODUCT n addmsg /kinetics/AC/AC1 /kinetics/AC/CaM-bind-AC1 SUBSTRATE n addmsg /kinetics/PKC-active/phosph-AC2 /kinetics/AC/AC2* MM_PRD pA addmsg /kinetics/AC/dephosph-AC2 /kinetics/AC/AC2* REAC A B addmsg /kinetics/AC/Gs-bind-AC2* /kinetics/AC/AC2* REAC A B addmsg /kinetics/AC/AC2* /kinetics/AC/AC2*/kenz ENZYME n addmsg /kinetics/AC/ATP /kinetics/AC/AC2*/kenz SUBSTRATE n addmsg /kinetics/AC/Gs-bind-AC2 /kinetics/AC/AC2-Gs REAC B A addmsg /kinetics/AC/AC2-Gs /kinetics/AC/AC2-Gs/kenz ENZYME n addmsg /kinetics/AC/ATP /kinetics/AC/AC2-Gs/kenz SUBSTRATE n addmsg /kinetics/AC/Gs-bind-AC2 /kinetics/AC/AC2 REAC A B addmsg /kinetics/PKC-active/phosph-AC2 /kinetics/AC/AC2 REAC sA B addmsg /kinetics/AC/dephosph-AC2 /kinetics/AC/AC2 REAC B A addmsg /kinetics/AC/AC2* /kinetics/AC/dephosph-AC2 SUBSTRATE n addmsg /kinetics/AC/AC2 /kinetics/AC/dephosph-AC2 PRODUCT n addmsg /kinetics/AC/Gs-bind-AC1 /kinetics/AC/AC1-Gs REAC B A addmsg /kinetics/AC/AC1-Gs /kinetics/AC/AC1-Gs/kenz ENZYME n addmsg /kinetics/AC/ATP /kinetics/AC/AC1-Gs/kenz SUBSTRATE n addmsg /kinetics/AC/AC2 /kinetics/AC/Gs-bind-AC2 SUBSTRATE n addmsg /kinetics/AC/AC2-Gs /kinetics/AC/Gs-bind-AC2 PRODUCT n addmsg /kinetics/Gs-alpha /kinetics/AC/Gs-bind-AC2 SUBSTRATE n addmsg /kinetics/Gs-alpha /kinetics/AC/Gs-bind-AC1 SUBSTRATE n addmsg /kinetics/AC/AC1 /kinetics/AC/Gs-bind-AC1 SUBSTRATE n addmsg /kinetics/AC/AC1-Gs /kinetics/AC/Gs-bind-AC1 PRODUCT n addmsg /kinetics/AC/cAMP-PDE*/PDE* /kinetics/AC/AMP MM_PRD pA addmsg /kinetics/AC/cAMP-PDE/PDE /kinetics/AC/AMP MM_PRD pA addmsg /kinetics/AC/CaM.PDE1/CaM.PDE1 /kinetics/AC/AMP MM_PRD pA addmsg /kinetics/AC/PDE1/PDE1 /kinetics/AC/AMP MM_PRD pA addmsg /kinetics/AC/Gs-bind-AC2* /kinetics/AC/AC2*-Gs REAC B A addmsg /kinetics/AC/AC2*-Gs /kinetics/AC/AC2*-Gs/kenz ENZYME n addmsg /kinetics/AC/ATP /kinetics/AC/AC2*-Gs/kenz SUBSTRATE n addmsg /kinetics/Gs-alpha /kinetics/AC/Gs-bind-AC2* SUBSTRATE n addmsg /kinetics/AC/AC2*-Gs /kinetics/AC/Gs-bind-AC2* PRODUCT n addmsg /kinetics/AC/AC2* /kinetics/AC/Gs-bind-AC2* SUBSTRATE n addmsg /kinetics/AC/cAMP-PDE/PDE /kinetics/AC/cAMP-PDE REAC eA B addmsg /kinetics/AC/dephosph-PDE /kinetics/AC/cAMP-PDE REAC B A addmsg /kinetics/PKA-active/phosph-PDE /kinetics/AC/cAMP-PDE REAC sA B addmsg /kinetics/AC/cAMP-PDE /kinetics/AC/cAMP-PDE/PDE ENZYME n addmsg /kinetics/cAMP /kinetics/AC/cAMP-PDE/PDE SUBSTRATE n addmsg /kinetics/AC/cAMP-PDE*/PDE* /kinetics/AC/cAMP-PDE* REAC eA B addmsg /kinetics/AC/dephosph-PDE /kinetics/AC/cAMP-PDE* REAC A B addmsg /kinetics/PKA-active/phosph-PDE /kinetics/AC/cAMP-PDE* MM_PRD pA addmsg /kinetics/AC/cAMP-PDE* /kinetics/AC/cAMP-PDE*/PDE* ENZYME n addmsg /kinetics/cAMP /kinetics/AC/cAMP-PDE*/PDE* SUBSTRATE n addmsg /kinetics/AC/cAMP-PDE* /kinetics/AC/dephosph-PDE SUBSTRATE n addmsg /kinetics/AC/cAMP-PDE /kinetics/AC/dephosph-PDE PRODUCT n addmsg /kinetics/AC/PDE1/PDE1 /kinetics/AC/PDE1 REAC eA B addmsg /kinetics/AC/CaM_bind_PDE1 /kinetics/AC/PDE1 REAC A B addmsg /kinetics/AC/PDE1 /kinetics/AC/PDE1/PDE1 ENZYME n addmsg /kinetics/cAMP /kinetics/AC/PDE1/PDE1 SUBSTRATE n addmsg /kinetics/AC/CaM.PDE1/CaM.PDE1 /kinetics/AC/CaM.PDE1 REAC eA B addmsg /kinetics/AC/CaM_bind_PDE1 /kinetics/AC/CaM.PDE1 REAC B A addmsg /kinetics/AC/CaM.PDE1 /kinetics/AC/CaM.PDE1/CaM.PDE1 ENZYME n addmsg /kinetics/cAMP /kinetics/AC/CaM.PDE1/CaM.PDE1 SUBSTRATE n addmsg /kinetics/AC/PDE1 /kinetics/AC/CaM_bind_PDE1 SUBSTRATE n addmsg /kinetics/AC/CaM.PDE1 /kinetics/AC/CaM_bind_PDE1 PRODUCT n addmsg /kinetics/CaM-Ca4 /kinetics/AC/CaM_bind_PDE1 SUBSTRATE n addmsg /kinetics/AC/Gs-bind-AC2 /kinetics/Gs-alpha REAC A B addmsg /kinetics/AC/Gs-bind-AC1 /kinetics/Gs-alpha REAC A B addmsg /kinetics/AC/Gs-bind-AC2* /kinetics/Gs-alpha REAC A B addmsg /kinetics/Glu /kinetics/remove_glu SUBSTRATE n addmsg /kinetics/synapse /kinetics/remove_glu PRODUCT n addmsg /kinetics/remove_glu /kinetics/synapse REAC B A addmsg /kinetics/stim /kinetics/synapse SLAVE output addmsg /kinetics/CaMKII/tot_CaM_CaMKII /kinetics/CaMKII-act SUMTOTAL n nInit addmsg /kinetics/CaMKII/tot_autonomous_CaMKII /kinetics/CaMKII-act SUMTOTAL n nInit addmsg /kinetics/CaM(Ca)n-CaNAB /kinetics/CaN-active SUMTOTAL n nInit addmsg /kinetics/CaNAB-Ca4 /kinetics/CaN-active SUMTOTAL n nInit addmsg /kinetics/PP1-active /kinetics/tot_PP1-act SUMTOTAL n nInit addmsg /kinetics/PP1-active/Deph-thr286 /kinetics/tot_PP1-act SUMTOTAL nComplex nComplexInit addmsg /kinetics/PP1-active/Deph-thr305 /kinetics/tot_PP1-act SUMTOTAL nComplex nComplexInit addmsg /kinetics/PP1-active/Deph-thr286c /kinetics/tot_PP1-act SUMTOTAL nComplex nComplexInit addmsg /kinetics/PP1-active/Deph_thr286b /kinetics/tot_PP1-act SUMTOTAL nComplex nComplexInit addmsg /kinetics/PP1-active/Deph-thr306 /kinetics/tot_PP1-act SUMTOTAL nComplex nComplexInit addmsg /kinetics/PKC-active /graphs/conc1/PKC-active.Co PLOT Co *PKC-active.Co *red addmsg /kinetics/MAPK* /graphs/conc1/MAPK*.Co PLOT Co *MAPK*.Co *orange addmsg /kinetics/PKA-active /graphs/conc2/PKA-active.Co PLOT Co *PKA-active.Co *yellow addmsg /kinetics/CaMKII-act /moregraphs/conc3/CaMKII-act.Co PLOT Co *CaMKII-act.Co *blue addmsg /kinetics/Ca /moregraphs/conc3/Ca.Co PLOT Co *Ca.Co *red addmsg /kinetics/CaN-active /moregraphs/conc4/CaN-active.Co PLOT Co *CaN-active.Co *blue addmsg /kinetics/tot_PP1-act /moregraphs/conc4/tot_PP1-act.Co PLOT Co *tot_PP1-act.Co *red enddump call /kinetics/tot_PP1-act/notes LOAD \ " tot_PP1 has inputs from Deph-thr286, PP1-active, Deph-thr305, Deph-thr286c, Deph-thr286b,Deph-thr305. except PP1-active all other inputs are enzyme-substrate complex which is not currently supported by doqcs." \ "But can be accessed from GENESIS file." // End of dump call /edit/draw/tree RESET reset