This is the <a href = "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8816754">Huang CY and Ferrell JE Jr. Proc Natl Acad Sci U S A. (1996) 93(19):10078-83</a> model for the MAPK cascade in Xenopus extracts. Wed Oct 18 16:10:27 2006 pathway Sridhar Hariharaputran, NCBS Huang, C.-Y.F. and Ferrell Jr., J.E. Xenopus Oocyte extract Cytosol Quantitative match to experiments Approximate implementation Approximates original data Km is 300 nM and Vmax is 150 from Huang and 1996 k1*MAPK_slash_MAPKKK*MAPK_slash_INPUT_po_E1_pc_-k2*MAPK_slash_INPUT_po_E1_pc__slash_INPUT_po_E1_pc__slash_INPUT_po_E1_pc__cplx $\mathrm{k1}\mathrm{MAPK\_slash\_MAPKKK}\mathrm{MAPK\_slash\_INPUT\_po\_E1\_pc\_}-\mathrm{k2}\mathrm{MAPK\_slash\_INPUT\_po\_E1\_pc\_\_slash\_INPUT\_po\_E1\_pc\_\_slash\_INPUT\_po\_E1\_pc\_\_cplx}$ k3*MAPK_slash_INPUT_po_E1_pc__slash_INPUT_po_E1_pc__slash_INPUT_po_E1_pc__cplx $\mathrm{k3}\mathrm{MAPK\_slash\_INPUT\_po\_E1\_pc\_\_slash\_INPUT\_po\_E1\_pc\_\_slash\_INPUT\_po\_E1\_pc\_\_cplx}$ Km is 300 nM and Vmax is 150 from Huang and 1996 k1*MAPK_slash_MAPKK*MAPK_slash_MAPKKK_star_-k2*MAPK_slash_MAPKKK_star__slash_MAPKKK_star__slash_MAPKKK_star__cplx $\mathrm{k1}\mathrm{MAPK\_slash\_MAPKK}\mathrm{MAPK\_slash\_MAPKKK\_star\_}-\mathrm{k2}\mathrm{MAPK\_slash\_MAPKKK\_star\_\_slash\_MAPKKK\_star\_\_slash\_MAPKKK\_star\_\_cplx}$ k3*MAPK_slash_MAPKKK_star__slash_MAPKKK_star__slash_MAPKKK_star__cplx $\mathrm{k3}\mathrm{MAPK\_slash\_MAPKKK\_star\_\_slash\_MAPKKK\_star\_\_slash\_MAPKKK\_star\_\_cplx}$ Km is 300 nM and Vmax is 150 from Huang and 1996 k1*MAPK_slash_MAPKK_minus_P*MAPK_slash_MAPKKK_star_-k2*MAPK_slash_MAPKKK_star__slash_MAPKKK_star__sbo_1_sbc__slash_MAPKKK_star__sbo_1_sbc__cplx $\mathrm{k1}\mathrm{MAPK\_slash\_MAPKK\_minus\_P}\mathrm{MAPK\_slash\_MAPKKK\_star\_}-\mathrm{k2}\mathrm{MAPK\_slash\_MAPKKK\_star\_\_slash\_MAPKKK\_star\_\_sbo\_1\_sbc\_\_slash\_MAPKKK\_star\_\_sbo\_1\_sbc\_\_cplx}$ k3*MAPK_slash_MAPKKK_star__slash_MAPKKK_star__sbo_1_sbc__slash_MAPKKK_star__sbo_1_sbc__cplx $\mathrm{k3}\mathrm{MAPK\_slash\_MAPKKK\_star\_\_slash\_MAPKKK\_star\_\_sbo\_1\_sbc\_\_slash\_MAPKKK\_star\_\_sbo\_1\_sbc\_\_cplx}$ Km is 300 nM and Vmax is 150 from Huang and 1996 k1*MAPK_slash_MAPKKK_star_*MAPK_slash_E2-k2*MAPK_slash_E2_slash_E2_slash_E2_cplx $\mathrm{k1}\mathrm{MAPK\_slash\_MAPKKK\_star\_}\mathrm{MAPK\_slash\_E2}-\mathrm{k2}\mathrm{MAPK\_slash\_E2\_slash\_E2\_slash\_E2\_cplx}$ k3*MAPK_slash_E2_slash_E2_slash_E2_cplx $\mathrm{k3}\mathrm{MAPK\_slash\_E2\_slash\_E2\_slash\_E2\_cplx}$ Km is 300 nM and Vmax is 150 from Huang and 1996 k1*MAPK_slash_MAPK*MAPK_slash_MAPKK_minus_PP-k2*MAPK_slash_MAPKK_minus_PP_slash_MAPKK_minus_PP_slash_MAPKK_minus_PP_cplx $\mathrm{k1}\mathrm{MAPK\_slash\_MAPK}\mathrm{MAPK\_slash\_MAPKK\_minus\_PP}-\mathrm{k2}\mathrm{MAPK\_slash\_MAPKK\_minus\_PP\_slash\_MAPKK\_minus\_PP\_slash\_MAPKK\_minus\_PP\_cplx}$ k3*MAPK_slash_MAPKK_minus_PP_slash_MAPKK_minus_PP_slash_MAPKK_minus_PP_cplx $\mathrm{k3}\mathrm{MAPK\_slash\_MAPKK\_minus\_PP\_slash\_MAPKK\_minus\_PP\_slash\_MAPKK\_minus\_PP\_cplx}$ Km is 300 nM and Vmax is 150 from Huang and 1996 k1*MAPK_slash_MAPK_minus_P*MAPK_slash_MAPKK_minus_PP-k2*MAPK_slash_MAPKK_minus_PP_slash_MAPKK_minus_PP_sbo_1_sbc__slash_MAPKK_minus_PP_sbo_1_sbc__cplx $\mathrm{k1}\mathrm{MAPK\_slash\_MAPK\_minus\_P}\mathrm{MAPK\_slash\_MAPKK\_minus\_PP}-\mathrm{k2}\mathrm{MAPK\_slash\_MAPKK\_minus\_PP\_slash\_MAPKK\_minus\_PP\_sbo\_1\_sbc\_\_slash\_MAPKK\_minus\_PP\_sbo\_1\_sbc\_\_cplx}$ k3*MAPK_slash_MAPKK_minus_PP_slash_MAPKK_minus_PP_sbo_1_sbc__slash_MAPKK_minus_PP_sbo_1_sbc__cplx $\mathrm{k3}\mathrm{MAPK\_slash\_MAPKK\_minus\_PP\_slash\_MAPKK\_minus\_PP\_sbo\_1\_sbc\_\_slash\_MAPKK\_minus\_PP\_sbo\_1\_sbc\_\_cplx}$ Km is 300 nM and Vmax is 150 from Huang and 1996 k1*MAPK_slash_MAPKK_minus_P*MAPK_slash_MAPKKPase-k2*MAPK_slash_MAPKKPase_slash_MAPKKPase_slash_MAPKKPase_cplx $\mathrm{k1}\mathrm{MAPK\_slash\_MAPKK\_minus\_P}\mathrm{MAPK\_slash\_MAPKKPase}-\mathrm{k2}\mathrm{MAPK\_slash\_MAPKKPase\_slash\_MAPKKPase\_slash\_MAPKKPase\_cplx}$ k3*MAPK_slash_MAPKKPase_slash_MAPKKPase_slash_MAPKKPase_cplx $\mathrm{k3}\mathrm{MAPK\_slash\_MAPKKPase\_slash\_MAPKKPase\_slash\_MAPKKPase\_cplx}$ Km is 300 nM and Vmax is 150 from Huang and 1996 k1*MAPK_slash_MAPKK_minus_PP*MAPK_slash_MAPKKPase_sbo_1_sbc_-k2*MAPK_slash_MAPKKPase_sbo_1_sbc__slash_MAPKKPase_slash_MAPKKPase_cplx $\mathrm{k1}\mathrm{MAPK\_slash\_MAPKK\_minus\_PP}\mathrm{MAPK\_slash\_MAPKKPase\_sbo\_1\_sbc\_}-\mathrm{k2}\mathrm{MAPK\_slash\_MAPKKPase\_sbo\_1\_sbc\_\_slash\_MAPKKPase\_slash\_MAPKKPase\_cplx}$ k3*MAPK_slash_MAPKKPase_sbo_1_sbc__slash_MAPKKPase_slash_MAPKKPase_cplx $\mathrm{k3}\mathrm{MAPK\_slash\_MAPKKPase\_sbo\_1\_sbc\_\_slash\_MAPKKPase\_slash\_MAPKKPase\_cplx}$ Km is 300 nM and Vmax is 150 from Huang and 1996 k1*MAPK_slash_MAPK_minus_P*MAPK_slash_MAPKPase-k2*MAPK_slash_MAPKPase_slash_MAPKPase_slash_MAPKPase_cplx $\mathrm{k1}\mathrm{MAPK\_slash\_MAPK\_minus\_P}\mathrm{MAPK\_slash\_MAPKPase}-\mathrm{k2}\mathrm{MAPK\_slash\_MAPKPase\_slash\_MAPKPase\_slash\_MAPKPase\_cplx}$ k3*MAPK_slash_MAPKPase_slash_MAPKPase_slash_MAPKPase_cplx $\mathrm{k3}\mathrm{MAPK\_slash\_MAPKPase\_slash\_MAPKPase\_slash\_MAPKPase\_cplx}$ Km is 300 nM and Vmax is 150 from Huang and 1996 k1*MAPK_slash_MAPK_minus_PP*MAPK_slash_MAPKPase_sbo_1_sbc_-k2*MAPK_slash_MAPKPase_sbo_1_sbc__slash_MAPKPase_slash_MAPKPase_cplx $\mathrm{k1}\mathrm{MAPK\_slash\_MAPK\_minus\_PP}\mathrm{MAPK\_slash\_MAPKPase\_sbo\_1\_sbc\_}-\mathrm{k2}\mathrm{MAPK\_slash\_MAPKPase\_sbo\_1\_sbc\_\_slash\_MAPKPase\_slash\_MAPKPase\_cplx}$ k3*MAPK_slash_MAPKPase_sbo_1_sbc__slash_MAPKPase_slash_MAPKPase_cplx $\mathrm{k3}\mathrm{MAPK\_slash\_MAPKPase\_sbo\_1\_sbc\_\_slash\_MAPKPase\_slash\_MAPKPase\_cplx}$