//genesis
// kkit Version 11 flat dumpfile
 
// Saved on Wed Jul  6 20:43:21 2005
 
include kkit {argv 1}
 
FASTDT = 0.0001
SIMDT = 0.001
CONTROLDT = 10
PLOTDT = 10
MAXTIME = 2000
TRANSIENT_TIME = 10
VARIABLE_DT_FLAG = 1
DEFAULT_VOL = 9e-20
VERSION = 11.0
setfield /file/modpath value /home2/bhalla/scripts/modules
kparms
 
//genesis

initdump -version 3 -ignoreorphans 1
simobjdump table input output alloced step_mode stepsize x y z
simobjdump xtree path script namemode sizescale
simobjdump xcoredraw xmin xmax ymin ymax
simobjdump xtext editable
simobjdump xgraph xmin xmax ymin ymax overlay
simobjdump xplot pixflags script fg ysquish do_slope wy
simobjdump group xtree_fg_req xtree_textfg_req plotfield expanded movealone \
  link savename file version md5sum mod_save_flag x y z
simobjdump geometry size dim shape outside x y z
simobjdump kpool DiffConst CoInit Co n nInit mwt nMin vol slave_enable \
  comptname xtree_fg_req xtree_textfg_req x y z
simobjdump kreac kf kb notes xtree_fg_req xtree_textfg_req x y z
simobjdump kenz CoComplexInit CoComplex nComplexInit nComplex vol k1 k2 k3 \
  keepconc usecomplex notes xtree_fg_req xtree_textfg_req link x y z
simobjdump stim level1 width1 delay1 level2 width2 delay2 baselevel trig_time \
  trig_mode notes xtree_fg_req xtree_textfg_req is_running x y z
simobjdump xtab input output alloced step_mode stepsize notes editfunc \
  xtree_fg_req xtree_textfg_req baselevel last_x last_y is_running x y z
simobjdump kchan perm gmax Vm is_active use_nernst notes xtree_fg_req \
  xtree_textfg_req x y z
simobjdump transport input output alloced step_mode stepsize dt delay clock \
  kf xtree_fg_req xtree_textfg_req x y z
simobjdump proto x y z
simobjdump text str
simobjdump doqcsinfo filename accessname accesstype transcriber developer \
  citation species tissue cellcompartment methodology sources \
  model_implementation model_validation editfunc
simundump geometry /kinetics/geometry 0 9e-20 3 sphere "" -127 119 0
simundump geometry /kinetics/geometry[1] 0 1e-20 3 sphere "" -121 247 0
simundump geometry /kinetics/geometry[2] 0 5e-18 3 sphere "" -127 85 0
simundump kpool /kinetics/Ca 1 0 0.08 0.08 4.32 4.32 0 0 54 0 \
  /kinetics/geometry red black -244.66 120.79 0
simundump group /kinetics/CaMKII 1 purple black x 0 0 "" defaultfile \
  defaultfile.g 0 0 0 -236 150 0
simundump kpool /kinetics/CaMKII/CaMKII 1 0 20 20 1080 1080 0 0 54 0 \
  /kinetics/geometry 1 purple -257 141 0
simundump kpool /kinetics/CaMKII/CaMKII-CaM 1 0 0 0 0 0 0 0 54 0 \
  /kinetics/geometry 51 purple -266 141 0
simundump kpool /kinetics/CaMKII/CaMKII-thr286*-CaM 1 0 0 0 0 0 0 0 54 0 \
  /kinetics/geometry 47 purple -270 141 0
simundump kpool /kinetics/CaMKII/CaMKII*** 1 0 0 0 0 0 0 0 54 0 \
  /kinetics/geometry cyan purple -253 141 0
simundump kreac /kinetics/CaMKII/CaMKII-bind-CaM 1 0.92592 5 "" white purple \
  -254 133 0
simundump kreac /kinetics/CaMKII/CaMK-thr286-bind-CaM 1 18.522 0.1 "" white \
  purple -261 133 0
simundump kpool /kinetics/CaMKII/CaMKII-thr286 1 0 0 0 0 0 0 0 54 0 \
  /kinetics/geometry red purple -261 141 0
simundump kpool /kinetics/CaMKII/tot_CaM_CaMKII 1 0 0 0 0 0 0 0 54 0 \
  /kinetics/geometry green purple -268 148 0
simundump kenz /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_305 1 6.3263e-11 \
  6.3263e-11 3.4162e-09 3.4162e-09 54 0.0048904 24 6 0 0 "" red green "" -256 \
  138 0
simundump kenz /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_286 1 2.4454e-08 \
  2.4454e-08 1.3205e-06 1.3205e-06 54 0.00040753 2 0.5 0 0 "" red green "" \
  -268 138 0
simundump kpool /kinetics/CaMKII/tot_autonomous_CaMKII 1 0 2 2 108 108 0 0 54 \
  0 /kinetics/geometry green purple -257 148 0
simundump kenz /kinetics/CaMKII/tot_autonomous_CaMKII/auton_305 1 4.9006e-08 \
  4.9006e-08 2.6463e-06 2.6463e-06 54 0.0031746 24 6 0 0 "" red green "" -256 \
  136 0
simundump kenz /kinetics/CaMKII/tot_autonomous_CaMKII/auton_286 1 1.8944e-05 \
  1.8944e-05 0.001023 0.001023 54 0.00026456 2 0.5 0 0 "" red green "" -268 \
  136 0
simundump kpool /kinetics/CaMKII/CaMK-thr305 1 0 0 0 0 0 0 0 54 0 \
  /kinetics/geometry palegreen purple -247 141 0
simundump kpool /kinetics/CaMKII/tot_CaMKII_cyt 0 0 22 22 1188 1188 0 0 54 0 \
  /kinetics/geometry 24 purple -252 152 0
simundump kpool /kinetics/CaMKII/act_CaMKII_cyt 0 0 2 2 108 108 0 0 54 0 \
  /kinetics/geometry 14 purple -262 150 0
simundump kpool /kinetics/CaMKII/basal_CaMKII_cyt 0 0 2 2 108 108 0 0 54 4 \
  /kinetics/geometry blue purple -260 154 0
simundump kreac /kinetics/CaMKII/back_2 0 0.3 1e-05 "" white purple -241 159 \
  0
simundump kreac /kinetics/CaMKII/back_1 0 0.3 1e-05 "" white purple -255 158 \
  0
simundump kreac /kinetics/CaMKII/transloc_1 0 2e-05 0 "" white purple -267 \
  158 0
simundump kreac /kinetics/CaMKII/transloc_2 0 2e-05 0 "" white purple -274 \
  158 0
simundump kpool /kinetics/CaMKII/basal_CaMKII_PSD_control 0 0 2 2 12 12 0 0 6 \
  4 /kinetics/geometry[1] 59 purple -232 179 0
simundump kreac /kinetics/CaMKII/Stoch_Basal_CaMKII_PSD 0 1 1 "" white purple \
  -235 187 0
simundump kpool /kinetics/CaMKII/CaMKII-thr305-PSD 0 0 0 0 0 0 0 0 6 0 \
  /kinetics/geometry[1] 30 purple -242 168 0
simundump kpool /kinetics/CaMKII/CaMKII***-PSD 0 0 0 0 0 0 0 0 6 0 \
  /kinetics/geometry[1] 0 purple -249 168 0
simundump kpool /kinetics/CaMKII/CaMKII-PSD 0 0 0 0 0 0 0 0 6 0 \
  /kinetics/geometry[1] 62 purple -255 168 0
simundump kpool /kinetics/CaMKII/NMDAR 0 0 120 120 720 720 0 0 6 0 \
  /kinetics/geometry[1] blue purple -282 153 0
simundump kpool /kinetics/CaMKII/CaMKII-thr286-PSD 0 0 0 0 0 0 0 0 6 0 \
  /kinetics/geometry[1] 57 purple -261 168 0
simundump kpool /kinetics/CaMKII/CaMKII-CaM-PSD 0 0 0 0 0 0 0 0 6 0 \
  /kinetics/geometry[1] 50 purple -267 168 0
simundump kpool /kinetics/CaMKII/CaMKII-thr286-CaM-PSD 0 0 0 0 0 0 0 0 6 0 \
  /kinetics/geometry[1] 47 purple -274 168 0
simundump kpool /kinetics/CaMKII/tot-auto-PSD 0 0 2 2 12 12 0 0 6 0 \
  /kinetics/geometry[1] 29 purple -252 176 0
simundump kenz /kinetics/CaMKII/tot-auto-PSD/auton-305-PSD 0 0 0 0 0 54.001 \
  0.04 24 6 0 0 "" red 29 "" -251 161 0
simundump kenz /kinetics/CaMKII/tot-auto-PSD/auton-286-PSD 0 0 0 0 0 7.732 \
  0.0033333 2 0.5 0 0 "" red 29 "" -269 162 0
simundump kreac /kinetics/CaMKII/CaMKII-diss-CaM 0 5 0 "" white purple -258 \
  174 0
simundump kreac /kinetics/CaMKII/CaMKII-bind-CaM-PSD 0 8.3333 0 "" white \
  purple -265 174 0
simundump kreac /kinetics/CaMKII/CaMKII-thr286-bind-CaM-PSD 0 166.67 0.1 "" \
  white purple -276 174 0
simundump kpool /kinetics/CaMKII/basal_CaMKII_PSD 0 0 2 2 12 12 0 0 6 0 \
  /kinetics/geometry[1] blue purple -245 183 0
simundump kpool /kinetics/CaMKII/tot_CaMKII_PSD 0 0 2 2 12 12 0 0 6 0 \
  /kinetics/geometry[1] 23 purple -252 186 0
simundump kpool /kinetics/CaMKII/actCaMKII-PSD 0 0 2 2 12 12 0 0 6 0 \
  /kinetics/geometry[1] 12 purple -261 184 0
simundump kenz /kinetics/CaMKII/actCaMKII-PSD/CaMKII 0 7.1375e-215 \
  7.1375e-215 4.2825e-214 4.2825e-214 6 0.0046296 2 0.5 0 0 "" red 12 "" -177 \
  226 0
simundump kenz /kinetics/CaMKII/actCaMKII-PSD/CaMKII[1] 0 3.588e-215 \
  3.588e-215 2.1528e-214 2.1528e-214 6 0.0046296 2 0.5 0 0 "" red 12 "" -191 \
  226 0
simundump kenz /kinetics/CaMKII/actCaMKII-PSD/CaMKII[2] 0 3.588e-215 \
  3.588e-215 2.1528e-214 2.1528e-214 6 0.0046296 2 0.5 0 0 "" red 12 "" -198 \
  226 0
simundump kenz /kinetics/CaMKII/actCaMKII-PSD/CaMKII[3] 0 1.8002e-215 \
  1.8002e-215 1.0801e-214 1.0801e-214 6 0.0046296 2 0.5 0 0 "" red 12 "" -213 \
  226 0
simundump kenz /kinetics/CaMKII/actCaMKII-PSD/CaMKII[4] 0 7.1375e-215 \
  7.1375e-215 4.2825e-214 4.2825e-214 6 0.0046296 2 0.5 0 0 "" red 12 "" -178 \
  216 0
simundump kenz /kinetics/CaMKII/actCaMKII-PSD/CaMKII[5] 0 3.588e-215 \
  3.588e-215 2.1528e-214 2.1528e-214 6 0.0046296 2 0.5 0 0 "" red 12 "" -189 \
  217 0
simundump kenz /kinetics/CaMKII/actCaMKII-PSD/CaMKII[6] 0 3.588e-215 \
  3.588e-215 2.1528e-214 2.1528e-214 6 0.0046296 2 0.5 0 0 "" red 12 "" -198 \
  217 0
simundump kenz /kinetics/CaMKII/actCaMKII-PSD/CaMKII[7] 0 1.8002e-215 \
  1.8002e-215 1.0801e-214 1.0801e-214 6 0.0046296 2 0.5 0 0 "" red 12 "" -215 \
  218 0
simundump kenz /kinetics/CaMKII/actCaMKII-PSD/CaMKII[8] 0 4.0667e-215 \
  4.0667e-215 2.44e-214 2.44e-214 6 0.0046296 2 0.5 0 0 "" red 12 "" -178 206 \
  0
simundump kenz /kinetics/CaMKII/actCaMKII-PSD/CaMKII[9] 0 2.0443e-215 \
  2.0443e-215 1.2266e-214 1.2266e-214 6 0.0046296 2 0.5 0 0 "" red 12 "" -190 \
  207 0
simundump kenz /kinetics/CaMKII/actCaMKII-PSD/CaMKII[10] 0 2.0443e-215 \
  2.0443e-215 1.2266e-214 1.2266e-214 6 0.0046296 2 0.5 0 0 "" red 12 "" -199 \
  207 0
simundump kenz /kinetics/CaMKII/actCaMKII-PSD/CaMKII[11] 0 1.0257e-215 \
  1.0257e-215 6.154e-215 6.154e-215 6 0.0046296 2 0.5 0 0 "" red 12 "" -212 \
  207 0
simundump kenz /kinetics/CaMKII/actCaMKII-PSD/CaMKII[12] 0 4.0667e-215 \
  4.0667e-215 2.44e-214 2.44e-214 6 0.0046296 2 0.5 0 0 "" red 12 "" -176 212 \
  0
simundump kenz /kinetics/CaMKII/actCaMKII-PSD/CaMKII[13] 0 2.0443e-215 \
  2.0443e-215 1.2266e-214 1.2266e-214 6 0.0046296 2 0.5 0 0 "" red 12 "" -194 \
  209 0
simundump kenz /kinetics/CaMKII/actCaMKII-PSD/CaMKII[14] 0 2.0443e-215 \
  2.0443e-215 1.2266e-214 1.2266e-214 6 0.0046296 2 0.5 0 0 "" red 12 "" -203 \
  217 0
simundump kenz /kinetics/CaMKII/actCaMKII-PSD/CaMKII[15] 0 1.0257e-215 \
  1.0257e-215 6.154e-215 6.154e-215 6 0.0046296 2 0.5 0 0 "" red 12 "" -216 \
  212 0
simundump kpool /kinetics/CaMKII/tot-CaM-CaMKII-PSD 0 0 0 0 0 0 0 0 6 0 \
  /kinetics/geometry[1] 47 purple -269 179 0
simundump kenz /kinetics/CaMKII/tot-CaM-CaMKII-PSD/CaM-act-305-PSD 0 0 0 0 0 \
  54.001 0.061599 24 6 0 0 "" red 47 "" -252 165 0
simundump kenz /kinetics/CaMKII/tot-CaM-CaMKII-PSD/CaM-act-286-PSD 0 0 0 0 0 \
  7.732 0.0051333 2 0.5 0 0 "" red 47 "" -270 166 0
simundump kpool /kinetics/CaMKII/286P-PSD 0 0 0 0 0 0 0 0 6 0 \
  /kinetics/geometry[1] 59 purple -270 186 0
simundump group /kinetics/CaM 1 blue black x 0 0 "" defaultfile defaultfile.g \
  0 0 0 -277 112 0
simundump kpool /kinetics/CaM/CaM 1 0 26.333 26.333 1422 1422 0 0 54 0 \
  /kinetics/geometry pink blue -279 124 0
simundump kreac /kinetics/CaM/CaM-TR2-bind-Ca 1 0.024691 72 "" white blue \
  -275 122 0
simundump kreac /kinetics/CaM/CaM-TR2-Ca2-bind-Ca 1 0.066667 10 "" white blue \
  -275 116 0
simundump kpool /kinetics/CaM/neurogranin-CaM 1 0 0 0 0 0 0 0 54 0 \
  /kinetics/geometry red blue -293 122 0
simundump kreac /kinetics/CaM/neurogranin-bind-CaM 1 0.0055556 1 "" white \
  blue -288 119 0
simundump kpool /kinetics/CaM/neurogranin* 1 0 0 0 0 0 0 0 54 0 \
  /kinetics/geometry red blue -293 112 0
simundump kpool /kinetics/CaM/neurogranin 1 0 10 10 540 540 0 0 54 0 \
  /kinetics/geometry red blue -293 117 0
simundump kreac /kinetics/CaM/dephosph-neurogranin 1 0.005 0 "" white blue \
  -288 114 0
simundump kpool /kinetics/CaM/CaM-PSD 1 0 26.333 26.333 158 158 0 0 6 0 \
  /kinetics/geometry[1] pink blue -316 182 0
simundump kreac /kinetics/CaM/CaM-TR2-bind-Ca-PSD 1 2 72 "" white blue -304 \
  180 0
simundump kreac /kinetics/CaM/CaM-TR2-Ca2-bind-Ca-PSD 1 0.6 10 "" white blue \
  -304 174 0
simundump kreac /kinetics/CaM/CaM-Ca3-bind-Ca-PSD 1 0.077502 10 "" white blue \
  -304 167 0
simundump kpool /kinetics/CaM/neurogranin-CaM_PSD 1 0 0 0 0 0 0 0 6 0 \
  /kinetics/geometry[1] red blue -338 200 0
simundump kpool /kinetics/CaM/neurogranin_PSD 1 0 10 10 60 60 0 0 6 0 \
  /kinetics/geometry[1] red blue -339 191 0
simundump kreac /kinetics/CaM/neurogranin-bind-CaM_PSD 1 0.05 1 "" white blue \
  -327 190 0
simundump kreac /kinetics/CaM/dephosph-neurogranin_PSD 1 0.005 0 "" white \
  blue -327 184 0
simundump kpool /kinetics/CaM/neurogranin*_PSD 1 0 0 0 0 0 0 0 6 0 \
  /kinetics/geometry[1] red blue -338 179 0
simundump kpool /kinetics/CaM/CaM-TR2-Ca2 1 0 0 0 0 0 0 0 54 0 \
  /kinetics/geometry pink blue -269 119 0
simundump kpool /kinetics/CaM/CaM-Ca3 1 0 0 0 0 0 0 0 54 0 /kinetics/geometry \
  hotpink blue -269 113 0
simundump kreac /kinetics/CaM/CaM-Ca3-bind-Ca 1 0.0086111 10 "" white blue \
  -274 111 0
simundump kpool /kinetics/CaM/CaM-Ca4-PSD 1 0 0 0 0 0 0 0 6 0 \
  /kinetics/geometry[1] blue blue -298 163 0
simundump kpool /kinetics/CaM/CaM-Ca3-PSD 1 0 0 0 0 0 0 0 6 0 \
  /kinetics/geometry[1] hotpink blue -298 171 0
simundump kpool /kinetics/CaM/CaM-TR2-Ca2-PSD 1 0 0 0 0 0 0 0 6 0 \
  /kinetics/geometry[1] pink blue -299 177 0
simundump kpool /kinetics/CaM/CaM-Ca4 1 0 0 0 0 0 0 0 54 0 /kinetics/geometry \
  blue blue -229.07 118.13 0
simundump kreac /kinetics/CaM/equilib 0 540 60 "" white blue -280 135 0
simundump group /kinetics/PP1 1 yellow black x 0 0 "" defaultfile \
  defaultfile.g 0 0 0 -266 95 0
simundump kpool /kinetics/PP1/I1 1 0 1.8 1.8 97.2 97.2 0 0 54 0 \
  /kinetics/geometry orange yellow -257.65 90.884 0
simundump kpool /kinetics/PP1/I1* 1 0 0 0 0 0 0 0 54 0 /kinetics/geometry \
  orange yellow -261.8 90.916 0
simundump kreac /kinetics/PP1/Inact-PP1 1 9.2589 0.1 "" white yellow -265.04 \
  92.818 0
simundump kpool /kinetics/PP1/PP1-I1* 1 0 0 0 0 0 0 0 54 0 /kinetics/geometry \
  brown yellow -263.39 96.271 0
simundump kpool /kinetics/PP1/PP1-I1 1 0 0 0 0 0 0 0 54 0 /kinetics/geometry \
  brown yellow -255.98 96.547 0
simundump kreac /kinetics/PP1/dissoc-PP1-I1 1 1 0 "" white yellow -262.14 \
  93.094 0
simundump kpool /kinetics/PP1/PP2A 1 0 0.11111 0.11111 6 6 0 0 54 0 \
  /kinetics/geometry red yellow -261 107 0
simundump kenz /kinetics/PP1/PP2A/PP2A-dephosph-I1 1 1.9933e-06 1.9933e-06 \
  0.00010764 0.00010764 54 0.01196 8.3334 2 0 0 "" red red "" -263.43 99.969 \
  0
simundump kenz /kinetics/PP1/PP2A/PP2A-dephosph-PP1-I* 1 0.00691 0.00691 \
  0.37314 0.37314 54 0.01196 8.3334 2 0 0 "" red red "" -261 105.86 0
simundump kenz /kinetics/PP1/PP2A/PP2A-dephosph-I1_PSD 1 2.2155e-07 \
  2.2155e-07 1.1964e-05 1.1964e-05 54.001 0.01196 8.3334 2 0 0 "" red red "" \
  -304 132 0
simundump kenz /kinetics/PP1/PP2A/PP2A-dephosph-PP1-I*_PSD 1 0.0012791 \
  0.0012791 0.06907 0.06907 54.001 0.01196 8.3334 2 0 0 "" red red "" -304 \
  154 0
simundump kpool /kinetics/PP1/PP1-active 1 0 1.8 1.8 97.2 97.2 0 0 54 0 \
  /kinetics/geometry cyan yellow -241 100 0
simundump kenz /kinetics/PP1/PP1-active/Deph-thr286 0 0 0 0 0 54 0.045397 10 \
  2.5 0 0 "" red cyan "" -270.55 124.86 0
simundump kenz /kinetics/PP1/PP1-active/Deph-thr286b 0 0 0 0 0 54 0.045397 10 \
  2.5 0 0 "" red cyan "" -261.55 124.86 0
simundump kenz /kinetics/PP1/PP1-active/Deph-thr305 0 0 0 0 0 54 0.045397 10 \
  2.5 0 0 "" red cyan "" -257.55 124.86 0
simundump kenz /kinetics/PP1/PP1-active/Deph-thr286c 0 0 0 0 0 54 0.045397 10 \
  2.5 0 0 "" red cyan "" -250.55 124.86 0
simundump kenz /kinetics/PP1/PP1-active/Deph-thr305a 0 0 0 0 0 54 0.045397 10 \
  2.5 0 0 "" red cyan "" -253.55 124.86 0
simundump group /kinetics/PP2B 1 red3 black x 0 0 "" defaultfile \
  defaultfile.g 0 0 0 -227.05 115.15 0
simundump kpool /kinetics/PP2B/CaNAB 1 0 1 1 54 54 0 0 54 0 \
  /kinetics/geometry tan red3 -225.7 112.55 0
simundump kpool /kinetics/PP2B/CaNAB-Ca2 1 0 0 0 0 0 0 0 54 0 \
  /kinetics/geometry tan red3 -228.26 112.46 0
simundump kreac /kinetics/PP2B/Ca-bind-CaNAB-Ca2 1 0.0012346 1 "" white red3 \
  -229.83 111.25 0
simundump kreac /kinetics/PP2B/Ca-bind-CaNAB 1 3.4321 1 "" white red3 -227.12 \
  111.11 0
simundump kreac /kinetics/PP2B/CaMCa4-bind-CaNAB 1 11.111 1 "" white red3 \
  -234.64 113.36 0
simundump kpool /kinetics/PP2B/CaNAB-Ca4 1 0 0 0 0 0 0 0 54 0 \
  /kinetics/geometry tan red3 -231.92 112.43 0
simundump kenz /kinetics/PP2B/CaNAB-Ca4/dephosph_inhib1_noCaM 1 0 0 0 0 54 \
  0.00063333 0.136 0.034 0 0 "" red tan "" -242.54 110.5 0
simundump kenz /kinetics/PP2B/CaNAB-Ca4/dephosph_inhib1_noCaM_PSD 1 0 0 0 0 \
  54.001 0.00063334 0.136 0.034 0 0 "" red tan "" -304 147 0
simundump kpool /kinetics/PP2B/CaM_Ca_n-CaNAB 1 0 0 0 0 0 0 0 54 0 \
  /kinetics/geometry 1 red3 -237.52 114.35 0
simundump kenz /kinetics/PP2B/CaM_Ca_n-CaNAB/dephosph_neurogranin 1 0 0 0 0 \
  54 0.0061778 2.67 0.67 0 0 "" red 1 "" -300 118 0
simundump kenz /kinetics/PP2B/CaM_Ca_n-CaNAB/dephosph_inhib1 1 0 0 0 0 54 \
  0.0063333 1.36 0.34 0 0 "" red 1 "" -249.74 103.64 0
simundump kenz /kinetics/PP2B/CaM_Ca_n-CaNAB/dephosph-PP1-I* 1 0 0 0 0 54 \
  0.0063333 1.36 0.34 0 0 "" white 1 "" -254 107 0
simundump kenz /kinetics/PP2B/CaM_Ca_n-CaNAB/dephosph_inhib1_PSD 1 0 0 0 0 \
  54.001 0.0063334 1.36 0.34 0 0 "" red 1 "" -304 135 0
simundump kenz /kinetics/PP2B/CaM_Ca_n-CaNAB/dephosph-PP1-I*_PSD 1 0 0 0 0 \
  54.001 0.0063334 1.36 0.34 0 0 "" white 1 "" -304 151 0
simundump kenz /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[17] 0 0 0 0 0 54 0.037256 8 \
  2 0 0 "" red 1 "" -204 193 0
simundump kenz /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[18] 0 0 0 0 0 54 0.037256 8 \
  2 0 0 "" red 1 "" -204 186 0
simundump kenz /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[19] 0 0 0 0 0 54 0.037256 8 \
  2 0 0 "" red 1 "" -204 180 0
simundump kenz /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[20] 0 0 0 0 0 54 0.037256 8 \
  2 0 0 "" red 1 "" -204 173 0
simundump kenz /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[21] 0 0 0 0 0 54 0.037256 8 \
  2 0 0 "" red 1 "" -196 193 0
simundump kenz /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[22] 0 0 0 0 0 54 0.037256 8 \
  2 0 0 "" red 1 "" -196 186 0
simundump kenz /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[23] 0 0 0 0 0 54 0.037256 8 \
  2 0 0 "" red 1 "" -196 181 0
simundump kenz /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[24] 0 0 0 0 0 54 0.037256 8 \
  2 0 0 "" red 1 "" -196 173 0
simundump kenz /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[25] 0 0 0 0 0 54 0.037256 8 \
  2 0 0 "" red 1 "" -186 193 0
simundump kenz /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[26] 0 0 0 0 0 54 0.037256 8 \
  2 0 0 "" red 1 "" -186 186 0
simundump kenz /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[27] 0 0 0 0 0 54 0.037256 8 \
  2 0 0 "" red 1 "" -186 179 0
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  network "Upinder S. Bhalla, NCBS" \
  "Arnold Hayer and Upinder S. Bhalla, NCBS" \
  "Hayer and Bhalla, PLoS Comput. Biol. 2005." "General Mammalian" Neuronal \
  "Synaptic Spine, Postsynaptic Density" "Quantitative match to experiments" \
  "<a href ="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16110334&query_hl=14">Hayer A, Bhalla US  PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29</a>. ( Peer-reviewed publication )" "Exact GENESIS implementation" \
  "Replicates original data , Qualitative predictions" show_dumpdb
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xtextload /file/notes \
"Same as reference model1.g, minus degradation and turnover" \
"reactions."
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addmsg /kinetics/CaM/CaM-TR2-bind-Ca /kinetics/Ca REAC A B 
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addmsg /kinetics/CaM/CaM-Ca3-bind-Ca /kinetics/Ca REAC A B 
addmsg /kinetics/PP2B/Ca-bind-CaNAB-Ca2 /kinetics/Ca REAC A B 
addmsg /kinetics/PP2B/Ca-bind-CaNAB-Ca2 /kinetics/Ca REAC A B 
addmsg /kinetics/PP2B/Ca-bind-CaNAB /kinetics/Ca REAC A B 
addmsg /kinetics/PP2B/Ca-bind-CaNAB /kinetics/Ca REAC A B 
addmsg /kinetics/Ca_stoch_cyt /kinetics/Ca REAC B A 
addmsg /kinetics/CaMKII/CaMKII-bind-CaM /kinetics/CaMKII/CaMKII REAC A B 
addmsg /kinetics/CaMKII/back_1 /kinetics/CaMKII/CaMKII REAC B A 
addmsg /kinetics/PP1/PP1-active/Deph-thr286b /kinetics/CaMKII/CaMKII MM_PRD pA 
addmsg /kinetics/PP1/PP1-active/Deph-thr305a /kinetics/CaMKII/CaMKII MM_PRD pA 
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addmsg /kinetics/CaMKII/tot_autonomous_CaMKII/auton_286 /kinetics/CaMKII/CaMKII-CaM REAC sA B 
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addmsg /kinetics/PP1/PP1-active/Deph-thr286c /kinetics/CaMKII/CaMKII*** REAC sA B 
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addmsg /kinetics/CaMKII/CaMKII-thr286 /kinetics/CaMKII/tot_autonomous_CaMKII SUMTOTAL n nInit 
addmsg /kinetics/CaMKII/CaMKII*** /kinetics/CaMKII/tot_autonomous_CaMKII SUMTOTAL n nInit 
addmsg /kinetics/CaMKII/tot_autonomous_CaMKII/auton_305 /kinetics/CaMKII/tot_autonomous_CaMKII REAC eA B 
addmsg /kinetics/CaMKII/tot_autonomous_CaMKII/auton_286 /kinetics/CaMKII/tot_autonomous_CaMKII REAC eA B 
addmsg /kinetics/CaMKII/basal_CaMKII_cyt /kinetics/CaMKII/tot_autonomous_CaMKII SUMTOTAL n nInit 
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addmsg /kinetics/CaMKII/CaMKII-thr286*-CaM /kinetics/CaMKII/tot_CaMKII_cyt SUMTOTAL n nInit 
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addmsg /kinetics/CaMKII/CaMKII*** /kinetics/CaMKII/tot_CaMKII_cyt SUMTOTAL n nInit 
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addmsg /kinetics/CaMKII/CaMKII /kinetics/CaMKII/tot_CaMKII_cyt SUMTOTAL n nInit 
addmsg /kinetics/CaMKII/basal_CaMKII_cyt /kinetics/CaMKII/tot_CaMKII_cyt SUMTOTAL n nInit 
addmsg /kinetics/CaMKII/tot_CaM_CaMKII /kinetics/CaMKII/act_CaMKII_cyt SUMTOTAL n nInit 
addmsg /kinetics/CaMKII/tot_autonomous_CaMKII /kinetics/CaMKII/act_CaMKII_cyt SUMTOTAL n nInit 
addmsg /kinetics/CaMKII/CaMKII-thr305-PSD /kinetics/CaMKII/back_2 SUBSTRATE n 
addmsg /kinetics/CaMKII/CaMK-thr305 /kinetics/CaMKII/back_2 PRODUCT n 
addmsg /kinetics/CaMKII/NMDAR /kinetics/CaMKII/back_2 PRODUCT n 
addmsg /kinetics/CaMKII/CaMKII-PSD /kinetics/CaMKII/back_1 SUBSTRATE n 
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addmsg /kinetics/CaMKII/Stoch_Basal_CaMKII_PSD /kinetics/CaMKII/basal_CaMKII_PSD_control REAC A B 
addmsg /kinetics/CaMKII/basal_CaMKII_PSD_control /kinetics/CaMKII/Stoch_Basal_CaMKII_PSD SUBSTRATE n 
addmsg /kinetics/CaMKII/basal_CaMKII_PSD /kinetics/CaMKII/Stoch_Basal_CaMKII_PSD PRODUCT n 
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addmsg /kinetics/CaM/equilib /kinetics/CaM/CaM-Ca4 REAC B A 
addmsg /kinetics/CaM/CaM-Ca4-PSD /kinetics/CaM/equilib SUBSTRATE n 
addmsg /kinetics/CaM/CaM-Ca4 /kinetics/CaM/equilib PRODUCT n 
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addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/dephosph_inhib1 /kinetics/PP1/I1 MM_PRD pA 
addmsg /kinetics/PP1/PP2A/PP2A-dephosph-I1 /kinetics/PP1/I1 MM_PRD pA 
addmsg /kinetics/PP1/dissoc-PP1-I1 /kinetics/PP1/I1 REAC B A 
addmsg /kinetics/PKA/PKA-active/PKA-phosph-I1 /kinetics/PP1/I1 REAC sA B 
addmsg /kinetics/PP1/Inact-PP1 /kinetics/PP1/I1* REAC A B 
addmsg /kinetics/PP2B/CaNAB-Ca4/dephosph_inhib1_noCaM /kinetics/PP1/I1* REAC sA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/dephosph_inhib1 /kinetics/PP1/I1* REAC sA B 
addmsg /kinetics/PP1/PP2A/PP2A-dephosph-I1 /kinetics/PP1/I1* REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA-phosph-I1 /kinetics/PP1/I1* MM_PRD pA 
addmsg /kinetics/PP1/PP1-I1* /kinetics/PP1/Inact-PP1 PRODUCT n 
addmsg /kinetics/PP1/I1* /kinetics/PP1/Inact-PP1 SUBSTRATE n 
addmsg /kinetics/PP1/PP1-active /kinetics/PP1/Inact-PP1 SUBSTRATE n 
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addmsg /kinetics/PP1/PP2A/PP2A-dephosph-PP1-I* /kinetics/PP1/PP1-I1* REAC sA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/dephosph-PP1-I* /kinetics/PP1/PP1-I1* REAC sA B 
addmsg /kinetics/PP1/dissoc-PP1-I1 /kinetics/PP1/PP1-I1 REAC A B 
addmsg /kinetics/PP1/PP2A/PP2A-dephosph-PP1-I* /kinetics/PP1/PP1-I1 MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/dephosph-PP1-I* /kinetics/PP1/PP1-I1 MM_PRD pA 
addmsg /kinetics/PP1/PP1-I1 /kinetics/PP1/dissoc-PP1-I1 SUBSTRATE n 
addmsg /kinetics/PP1/PP1-active /kinetics/PP1/dissoc-PP1-I1 PRODUCT n 
addmsg /kinetics/PP1/I1 /kinetics/PP1/dissoc-PP1-I1 PRODUCT n 
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addmsg /kinetics/PP1/PP2A/PP2A-dephosph-PP1-I* /kinetics/PP1/PP2A REAC eA B 
addmsg /kinetics/PP1/PP2A/PP2A-dephosph-I1_PSD /kinetics/PP1/PP2A REAC eA B 
addmsg /kinetics/PP1/PP2A/PP2A-dephosph-PP1-I*_PSD /kinetics/PP1/PP2A REAC eA B 
addmsg /kinetics/PP1/PP2A /kinetics/PP1/PP2A/PP2A-dephosph-I1 ENZYME n 
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addmsg /kinetics/PP1/PP2A /kinetics/PP1/PP2A/PP2A-dephosph-I1_PSD ENZYME n 
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addmsg /kinetics/PP1/PP2A /kinetics/PP1/PP2A/PP2A-dephosph-PP1-I*_PSD ENZYME n 
addmsg /kinetics/PP1_PSD/PP1-I1* /kinetics/PP1/PP2A/PP2A-dephosph-PP1-I*_PSD SUBSTRATE n 
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addmsg /kinetics/PP1/dissoc-PP1-I1 /kinetics/PP1/PP1-active REAC B A 
addmsg /kinetics/PP1/PP1-active/Deph-thr286 /kinetics/PP1/PP1-active REAC eA B 
addmsg /kinetics/PP1/PP1-active/Deph-thr286b /kinetics/PP1/PP1-active REAC eA B 
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addmsg /kinetics/PP1/PP1-active/Deph-thr286c /kinetics/PP1/PP1-active REAC eA B 
addmsg /kinetics/PP1/PP1-active/Deph-thr305a /kinetics/PP1/PP1-active REAC eA B 
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addmsg /kinetics/CaMKII/CaMKII*** /kinetics/PP1/PP1-active/Deph-thr305 SUBSTRATE n 
addmsg /kinetics/PP1/PP1-active /kinetics/PP1/PP1-active/Deph-thr286c ENZYME n 
addmsg /kinetics/CaMKII/CaMKII*** /kinetics/PP1/PP1-active/Deph-thr286c SUBSTRATE n 
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addmsg /kinetics/CaMKII/CaMK-thr305 /kinetics/PP1/PP1-active/Deph-thr305a SUBSTRATE n 
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addmsg /kinetics/PP2B/Ca-bind-CaNAB /kinetics/PP2B/CaNAB-Ca2 REAC B A 
addmsg /kinetics/PP2B/Ca-bind-CaNAB-Ca2 /kinetics/PP2B/CaNAB-Ca2 REAC A B 
addmsg /kinetics/PP2B/CaNAB-Ca4 /kinetics/PP2B/Ca-bind-CaNAB-Ca2 PRODUCT n 
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addmsg /kinetics/Ca /kinetics/PP2B/Ca-bind-CaNAB-Ca2 SUBSTRATE n 
addmsg /kinetics/PP2B/CaNAB-Ca2 /kinetics/PP2B/Ca-bind-CaNAB-Ca2 SUBSTRATE n 
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addmsg /kinetics/PP2B/CaNAB-Ca2 /kinetics/PP2B/Ca-bind-CaNAB PRODUCT n 
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addmsg /kinetics/Ca /kinetics/PP2B/Ca-bind-CaNAB SUBSTRATE n 
addmsg /kinetics/CaM/CaM-Ca4 /kinetics/PP2B/CaMCa4-bind-CaNAB SUBSTRATE n 
addmsg /kinetics/PP2B/CaNAB-Ca4 /kinetics/PP2B/CaMCa4-bind-CaNAB SUBSTRATE n 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB /kinetics/PP2B/CaMCa4-bind-CaNAB PRODUCT n 
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addmsg /kinetics/PP2B/Ca-bind-CaNAB-Ca2 /kinetics/PP2B/CaNAB-Ca4 REAC B A 
addmsg /kinetics/PP2B/CaMCa4-bind-CaNAB /kinetics/PP2B/CaNAB-Ca4 REAC A B 
addmsg /kinetics/PP2B/CaNAB-Ca4/dephosph_inhib1_noCaM_PSD /kinetics/PP2B/CaNAB-Ca4 REAC eA B 
addmsg /kinetics/PP2B/CaNAB-Ca4 /kinetics/PP2B/CaNAB-Ca4/dephosph_inhib1_noCaM ENZYME n 
addmsg /kinetics/PP1/I1* /kinetics/PP2B/CaNAB-Ca4/dephosph_inhib1_noCaM SUBSTRATE n 
addmsg /kinetics/PP2B/CaNAB-Ca4 /kinetics/PP2B/CaNAB-Ca4/dephosph_inhib1_noCaM_PSD ENZYME n 
addmsg /kinetics/PP1_PSD/I1* /kinetics/PP2B/CaNAB-Ca4/dephosph_inhib1_noCaM_PSD SUBSTRATE n 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/dephosph_neurogranin /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/dephosph_inhib1 /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/dephosph-PP1-I* /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/dephosph_inhib1_PSD /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/dephosph-PP1-I*_PSD /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[17] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[18] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[19] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[20] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[21] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[22] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[23] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[24] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[25] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[26] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[27] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[28] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[29] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[30] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[31] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[32] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[1] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[2] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[3] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[4] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[5] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[6] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[7] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[8] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[9] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[10] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[11] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[12] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[13] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[14] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[15] /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/dephosph_neurogranin_PSD /kinetics/PP2B/CaM_Ca_n-CaNAB REAC eA B 
addmsg /kinetics/PP2B/CaMCa4-bind-CaNAB /kinetics/PP2B/CaM_Ca_n-CaNAB REAC B A 
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addmsg /kinetics/CaM/neurogranin* /kinetics/PP2B/CaM_Ca_n-CaNAB/dephosph_neurogranin SUBSTRATE n 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB /kinetics/PP2B/CaM_Ca_n-CaNAB/dephosph_inhib1 ENZYME n 
addmsg /kinetics/PP1/I1* /kinetics/PP2B/CaM_Ca_n-CaNAB/dephosph_inhib1 SUBSTRATE n 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB /kinetics/PP2B/CaM_Ca_n-CaNAB/dephosph-PP1-I* ENZYME n 
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addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB /kinetics/PP2B/CaM_Ca_n-CaNAB/dephosph_inhib1_PSD ENZYME n 
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addmsg /kinetics/PP1_PSD/PP1-I1* /kinetics/PP2B/CaM_Ca_n-CaNAB/dephosph-PP1-I*_PSD SUBSTRATE n 
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addmsg /kinetics/AMPAR/A845*_B /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[17] SUBSTRATE n 
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addmsg /kinetics/AMPAR/A831*845*_B831* /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[20] SUBSTRATE n 
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addmsg /kinetics/AMPAR/A845*_B831*845* /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[27] SUBSTRATE n 
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addmsg /kinetics/CaM/CaM-Ca3-bind-Ca-PSD /kinetics/Ca-PSD REAC A B 
addmsg /kinetics/Ca_stoch_PSD /kinetics/Ca-PSD REAC B A 
addmsg /kinetics/PP1_PSD/dissoc-PP1-I1 /kinetics/PP1_PSD/I1 REAC B A 
addmsg /kinetics/PKA/PKA-active/PKA-phosph-I1_PSD /kinetics/PP1_PSD/I1 REAC sA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/dephosph_inhib1_PSD /kinetics/PP1_PSD/I1 MM_PRD pA 
addmsg /kinetics/PP1/PP2A/PP2A-dephosph-I1_PSD /kinetics/PP1_PSD/I1 MM_PRD pA 
addmsg /kinetics/PP2B/CaNAB-Ca4/dephosph_inhib1_noCaM_PSD /kinetics/PP1_PSD/I1 MM_PRD pA 
addmsg /kinetics/PP1_PSD/Inact-PP1 /kinetics/PP1_PSD/I1* REAC A B 
addmsg /kinetics/PKA/PKA-active/PKA-phosph-I1_PSD /kinetics/PP1_PSD/I1* MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/dephosph_inhib1_PSD /kinetics/PP1_PSD/I1* REAC sA B 
addmsg /kinetics/PP1/PP2A/PP2A-dephosph-I1_PSD /kinetics/PP1_PSD/I1* REAC sA B 
addmsg /kinetics/PP2B/CaNAB-Ca4/dephosph_inhib1_noCaM_PSD /kinetics/PP1_PSD/I1* REAC sA B 
addmsg /kinetics/PP1_PSD/Inact-PP1 /kinetics/PP1_PSD/PP1-I1* REAC B A 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/dephosph-PP1-I*_PSD /kinetics/PP1_PSD/PP1-I1* REAC sA B 
addmsg /kinetics/PP1/PP2A/PP2A-dephosph-PP1-I*_PSD /kinetics/PP1_PSD/PP1-I1* REAC sA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/dephosph-PP1-I*_PSD /kinetics/PP1_PSD/PP1-I1 MM_PRD pA 
addmsg /kinetics/PP1/PP2A/PP2A-dephosph-PP1-I*_PSD /kinetics/PP1_PSD/PP1-I1 MM_PRD pA 
addmsg /kinetics/PP1_PSD/dissoc-PP1-I1 /kinetics/PP1_PSD/PP1-I1 REAC A B 
addmsg /kinetics/PP1_PSD/I1 /kinetics/PP1_PSD/dissoc-PP1-I1 PRODUCT n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/dissoc-PP1-I1 PRODUCT n 
addmsg /kinetics/PP1_PSD/PP1-I1 /kinetics/PP1_PSD/dissoc-PP1-I1 SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/Deph-thr286 /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/Deph-thr286b /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/Deph-thr305 /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/Deph-thr305a /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/Deph-thr286c /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/dissoc-PP1-I1 /kinetics/PP1_PSD/PP1-active_PSD REAC B A 
addmsg /kinetics/PP1_PSD/Inact-PP1 /kinetics/PP1_PSD/PP1-active_PSD REAC A B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1 /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[1] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[2] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[3] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[4] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[5] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[6] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[7] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[8] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[9] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[10] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[11] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[12] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[13] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[14] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[15] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[16] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[17] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[18] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[19] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[20] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[21] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[22] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[23] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[24] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[25] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[26] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[27] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[28] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[29] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[30] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[31] /kinetics/PP1_PSD/PP1-active_PSD REAC eA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/Deph-thr286 ENZYME n 
addmsg /kinetics/CaMKII/CaMKII-thr286-CaM-PSD /kinetics/PP1_PSD/PP1-active_PSD/Deph-thr286 SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/Deph-thr286b ENZYME n 
addmsg /kinetics/CaMKII/CaMKII-thr286-PSD /kinetics/PP1_PSD/PP1-active_PSD/Deph-thr286b SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/Deph-thr305 ENZYME n 
addmsg /kinetics/CaMKII/CaMKII***-PSD /kinetics/PP1_PSD/PP1-active_PSD/Deph-thr305 SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/Deph-thr286c ENZYME n 
addmsg /kinetics/CaMKII/CaMKII***-PSD /kinetics/PP1_PSD/PP1-active_PSD/Deph-thr286c SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1 ENZYME n 
addmsg /kinetics/AMPAR_memb/A845*_B845* /kinetics/PP1_PSD/PP1-active_PSD/PP1 SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[1] ENZYME n 
addmsg /kinetics/AMPAR_memb/A845*_B845* /kinetics/PP1_PSD/PP1-active_PSD/PP1[1] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[2] ENZYME n 
addmsg /kinetics/AMPAR_memb/A845*_B /kinetics/PP1_PSD/PP1-active_PSD/PP1[2] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[3] ENZYME n 
addmsg /kinetics/AMPAR_memb/A_B845* /kinetics/PP1_PSD/PP1-active_PSD/PP1[3] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[4] ENZYME n 
addmsg /kinetics/AMPAR_memb/A831*845*_B845* /kinetics/PP1_PSD/PP1-active_PSD/PP1[4] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[5] ENZYME n 
addmsg /kinetics/AMPAR_memb/A831*845*_B845* /kinetics/PP1_PSD/PP1-active_PSD/PP1[5] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[6] ENZYME n 
addmsg /kinetics/AMPAR_memb/A831*_B845* /kinetics/PP1_PSD/PP1-active_PSD/PP1[6] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[7] ENZYME n 
addmsg /kinetics/AMPAR_memb/A831*845*_B /kinetics/PP1_PSD/PP1-active_PSD/PP1[7] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[8] ENZYME n 
addmsg /kinetics/AMPAR_memb/A831*845*_B845* /kinetics/PP1_PSD/PP1-active_PSD/PP1[8] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[9] ENZYME n 
addmsg /kinetics/AMPAR_memb/A831*_B845* /kinetics/PP1_PSD/PP1-active_PSD/PP1[9] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[10] ENZYME n 
addmsg /kinetics/AMPAR_memb/A831*845*_B /kinetics/PP1_PSD/PP1-active_PSD/PP1[10] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[11] ENZYME n 
addmsg /kinetics/AMPAR_memb/A831*_B /kinetics/PP1_PSD/PP1-active_PSD/PP1[11] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[12] ENZYME n 
addmsg /kinetics/AMPAR_memb/A845*_B831*845* /kinetics/PP1_PSD/PP1-active_PSD/PP1[12] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[13] ENZYME n 
addmsg /kinetics/AMPAR_memb/A845*_B831*845* /kinetics/PP1_PSD/PP1-active_PSD/PP1[13] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[14] ENZYME n 
addmsg /kinetics/AMPAR_memb/A_B831*845* /kinetics/PP1_PSD/PP1-active_PSD/PP1[14] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[15] ENZYME n 
addmsg /kinetics/AMPAR_memb/A845*_B831* /kinetics/PP1_PSD/PP1-active_PSD/PP1[15] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[16] ENZYME n 
addmsg /kinetics/AMPAR_memb/A835*845*_B835*845* /kinetics/PP1_PSD/PP1-active_PSD/PP1[16] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[17] ENZYME n 
addmsg /kinetics/AMPAR_memb/A835*845*_B835*845* /kinetics/PP1_PSD/PP1-active_PSD/PP1[17] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[18] ENZYME n 
addmsg /kinetics/AMPAR_memb/A831*_B831*845* /kinetics/PP1_PSD/PP1-active_PSD/PP1[18] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[19] ENZYME n 
addmsg /kinetics/AMPAR_memb/A831*845*_B831* /kinetics/PP1_PSD/PP1-active_PSD/PP1[19] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[20] ENZYME n 
addmsg /kinetics/AMPAR_memb/A_B831*845* /kinetics/PP1_PSD/PP1-active_PSD/PP1[20] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[21] ENZYME n 
addmsg /kinetics/AMPAR_memb/A845*_B831*845* /kinetics/PP1_PSD/PP1-active_PSD/PP1[21] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[22] ENZYME n 
addmsg /kinetics/AMPAR_memb/A845*_B831* /kinetics/PP1_PSD/PP1-active_PSD/PP1[22] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[23] ENZYME n 
addmsg /kinetics/AMPAR_memb/A_B831* /kinetics/PP1_PSD/PP1-active_PSD/PP1[23] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[24] ENZYME n 
addmsg /kinetics/AMPAR_memb/A835*845*_B835*845* /kinetics/PP1_PSD/PP1-active_PSD/PP1[24] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[25] ENZYME n 
addmsg /kinetics/AMPAR_memb/A831*_B831*845* /kinetics/PP1_PSD/PP1-active_PSD/PP1[25] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[26] ENZYME n 
addmsg /kinetics/AMPAR_memb/A831*845*_B831* /kinetics/PP1_PSD/PP1-active_PSD/PP1[26] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[27] ENZYME n 
addmsg /kinetics/AMPAR_memb/A831*_B831* /kinetics/PP1_PSD/PP1-active_PSD/PP1[27] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[28] ENZYME n 
addmsg /kinetics/AMPAR_memb/A835*845*_B835*845* /kinetics/PP1_PSD/PP1-active_PSD/PP1[28] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[29] ENZYME n 
addmsg /kinetics/AMPAR_memb/A831*_B831*845* /kinetics/PP1_PSD/PP1-active_PSD/PP1[29] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[30] ENZYME n 
addmsg /kinetics/AMPAR_memb/A831*845*_B831* /kinetics/PP1_PSD/PP1-active_PSD/PP1[30] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/PP1[31] ENZYME n 
addmsg /kinetics/AMPAR_memb/A831*_B831* /kinetics/PP1_PSD/PP1-active_PSD/PP1[31] SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/PP1-active_PSD/Deph-thr305a ENZYME n 
addmsg /kinetics/CaMKII/CaMKII-thr305-PSD /kinetics/PP1_PSD/PP1-active_PSD/Deph-thr305a SUBSTRATE n 
addmsg /kinetics/PP1_PSD/I1* /kinetics/PP1_PSD/Inact-PP1 SUBSTRATE n 
addmsg /kinetics/PP1_PSD/PP1-I1* /kinetics/PP1_PSD/Inact-PP1 PRODUCT n 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /kinetics/PP1_PSD/Inact-PP1 SUBSTRATE n 
addmsg /kinetics/PKC-active/PKC-phosph-neurogranin /kinetics/PKC-active REAC eA B 
addmsg /kinetics/PKC-active/PKC-phosph-ng-CaM /kinetics/PKC-active REAC eA B 
addmsg /kinetics/PKC-active/phosph-AC2 /kinetics/PKC-active REAC eA B 
addmsg /kinetics/PKC-active/PKC-phosph-ng-CaM_PSD /kinetics/PKC-active REAC eA B 
addmsg /kinetics/PKC-active/PKC-phosph-neurogranin_PSD /kinetics/PKC-active REAC eA B 
addmsg /kinetics/PKC-stoch-input /kinetics/PKC-active REAC B A 
addmsg /kinetics/PKC-active /kinetics/PKC-active/PKC-phosph-neurogranin ENZYME n 
addmsg /kinetics/CaM/neurogranin /kinetics/PKC-active/PKC-phosph-neurogranin SUBSTRATE n 
addmsg /kinetics/PKC-active /kinetics/PKC-active/PKC-phosph-ng-CaM ENZYME n 
addmsg /kinetics/CaM/neurogranin-CaM /kinetics/PKC-active/PKC-phosph-ng-CaM SUBSTRATE n 
addmsg /kinetics/PKC-active /kinetics/PKC-active/phosph-AC2 ENZYME n 
addmsg /kinetics/AC/AC2 /kinetics/PKC-active/phosph-AC2 SUBSTRATE n 
addmsg /kinetics/PKC-active /kinetics/PKC-active/PKC-phosph-neurogranin_PSD ENZYME n 
addmsg /kinetics/CaM/neurogranin_PSD /kinetics/PKC-active/PKC-phosph-neurogranin_PSD SUBSTRATE n 
addmsg /kinetics/PKC-active /kinetics/PKC-active/PKC-phosph-ng-CaM_PSD ENZYME n 
addmsg /kinetics/CaM/neurogranin-CaM_PSD /kinetics/PKC-active/PKC-phosph-ng-CaM_PSD SUBSTRATE n 
addmsg /kinetics/AMPAR/endo_const /kinetics/AMPAR/GluR23_I REAC B A 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[17] /kinetics/AMPAR/A_B MM_PRD pA 
addmsg /kinetics/PKA/PKA-active/PKA[17] /kinetics/AMPAR/A_B REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[20] /kinetics/AMPAR/A_B REAC sA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[21] /kinetics/AMPAR/A_B MM_PRD pA 
addmsg /kinetics/AMPAR/recycle__ /kinetics/AMPAR/A_B REAC B A 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[18] /kinetics/AMPAR/A831*_B MM_PRD pA 
addmsg /kinetics/PKA/PKA-active/PKA[16] /kinetics/AMPAR/A831*_B REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[21] /kinetics/AMPAR/A831*_B REAC sA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[22] /kinetics/AMPAR/A831*_B MM_PRD pA 
addmsg /kinetics/AMPAR/recycle*_ /kinetics/AMPAR/A831*_B REAC B A 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[17] /kinetics/AMPAR/A845*_B REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[17] /kinetics/AMPAR/A845*_B MM_PRD pA 
addmsg /kinetics/PKA/PKA-active/PKA[28] /kinetics/AMPAR/A845*_B REAC sA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[29] /kinetics/AMPAR/A845*_B MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[18] /kinetics/AMPAR/A831*845*_B REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[16] /kinetics/AMPAR/A831*845*_B MM_PRD pA 
addmsg /kinetics/PKA/PKA-active/PKA[29] /kinetics/AMPAR/A831*845*_B REAC sA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[30] /kinetics/AMPAR/A831*845*_B MM_PRD pA 
addmsg /kinetics/PKA/PKA-active/PKA[20] /kinetics/AMPAR/A_B845* MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[21] /kinetics/AMPAR/A_B845* REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[24] /kinetics/AMPAR/A_B845* REAC sA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[25] /kinetics/AMPAR/A_B845* MM_PRD pA 
addmsg /kinetics/PKA/PKA-active/PKA[24] /kinetics/AMPAR/A845*_B845* MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[25] /kinetics/AMPAR/A845*_B845* REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[28] /kinetics/AMPAR/A845*_B845* MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[29] /kinetics/AMPAR/A845*_B845* REAC sA B 
addmsg /kinetics/AMPAR/exo_reg__ /kinetics/AMPAR/A845*_B845* REAC A B 
addmsg /kinetics/PKA/PKA-active/PKA[25] /kinetics/AMPAR/A831*845*_B845* MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[26] /kinetics/AMPAR/A831*845*_B845* REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[29] /kinetics/AMPAR/A831*845*_B845* MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[30] /kinetics/AMPAR/A831*845*_B845* REAC sA B 
addmsg /kinetics/AMPAR/exo_reg*_ /kinetics/AMPAR/A831*845*_B845* REAC A B 
addmsg /kinetics/PKA/PKA-active/PKA[26] /kinetics/AMPAR/A845*_B831*845* MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[27] /kinetics/AMPAR/A845*_B831*845* REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[30] /kinetics/AMPAR/A845*_B831*845* MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[31] /kinetics/AMPAR/A845*_B831*845* REAC sA B 
addmsg /kinetics/AMPAR/exo_reg_* /kinetics/AMPAR/A845*_B831*845* REAC A B 
addmsg /kinetics/PKA/PKA-active/PKA[27] /kinetics/AMPAR/A835*845*_B835*845* MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[28] /kinetics/AMPAR/A835*845*_B835*845* REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[31] /kinetics/AMPAR/A835*845*_B835*845* MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[32] /kinetics/AMPAR/A835*845*_B835*845* REAC sA B 
addmsg /kinetics/AMPAR/exo_reg** /kinetics/AMPAR/A835*845*_B835*845* REAC A B 
addmsg /kinetics/PKA/PKA-active/PKA[22] /kinetics/AMPAR/A_B831*845* MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[23] /kinetics/AMPAR/A_B831*845* REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[26] /kinetics/AMPAR/A_B831*845* REAC sA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[27] /kinetics/AMPAR/A_B831*845* MM_PRD pA 
addmsg /kinetics/PKA/PKA-active/PKA[23] /kinetics/AMPAR/A831*_B831*845* MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[24] /kinetics/AMPAR/A831*_B831*845* REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[27] /kinetics/AMPAR/A831*_B831*845* REAC sA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[28] /kinetics/AMPAR/A831*_B831*845* MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[19] /kinetics/AMPAR/A_B831* MM_PRD pA 
addmsg /kinetics/PKA/PKA-active/PKA[18] /kinetics/AMPAR/A_B831* REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[22] /kinetics/AMPAR/A_B831* REAC sA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[23] /kinetics/AMPAR/A_B831* MM_PRD pA 
addmsg /kinetics/AMPAR/recycle_* /kinetics/AMPAR/A_B831* REAC B A 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[19] /kinetics/AMPAR/A845*_B831* REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[18] /kinetics/AMPAR/A845*_B831* MM_PRD pA 
addmsg /kinetics/PKA/PKA-active/PKA[30] /kinetics/AMPAR/A845*_B831* REAC sA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[31] /kinetics/AMPAR/A845*_B831* MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[20] /kinetics/AMPAR/A831*_B831* MM_PRD pA 
addmsg /kinetics/PKA/PKA-active/PKA[19] /kinetics/AMPAR/A831*_B831* REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[23] /kinetics/AMPAR/A831*_B831* REAC sA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[24] /kinetics/AMPAR/A831*_B831* MM_PRD pA 
addmsg /kinetics/AMPAR/recycle** /kinetics/AMPAR/A831*_B831* REAC B A 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[20] /kinetics/AMPAR/A831*845*_B831* REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[19] /kinetics/AMPAR/A831*845*_B831* MM_PRD pA 
addmsg /kinetics/PKA/PKA-active/PKA[31] /kinetics/AMPAR/A831*845*_B831* REAC sA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[32] /kinetics/AMPAR/A831*845*_B831* MM_PRD pA 
addmsg /kinetics/AMPAR/A831*_B831* /kinetics/AMPAR/recycle** PRODUCT n 
addmsg /kinetics/AMPAR_memb/A831*_B831* /kinetics/AMPAR/recycle** SUBSTRATE n 
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addmsg /kinetics/AMPAR/A_B831* /kinetics/AMPAR/recycle_* PRODUCT n 
addmsg /kinetics/AMPAR_memb/A_B831* /kinetics/AMPAR/recycle_* SUBSTRATE n 
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addmsg /kinetics/AMPAR_memb/Anchor /kinetics/AMPAR/recycle*_ PRODUCT n 
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addmsg /kinetics/AMPAR_memb/A_B /kinetics/AMPAR/recycle__ SUBSTRATE n 
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addmsg /kinetics/AMPAR/A835*845*_B835*845* /kinetics/AMPAR/exo_reg** SUBSTRATE n 
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addmsg /kinetics/AMPAR/A845*_B831*845* /kinetics/AMPAR/exo_reg_* SUBSTRATE n 
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addmsg /kinetics/AMPAR/A831*845*_B845* /kinetics/AMPAR/exo_reg*_ SUBSTRATE n 
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addmsg /kinetics/AMPAR/A845*_B845* /kinetics/AMPAR/exo_reg__ SUBSTRATE n 
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addmsg /kinetics/AMPAR/GluR23_I /kinetics/AMPAR/endo_const PRODUCT n 
addmsg /kinetics/AMPAR_memb/GluR23_M /kinetics/AMPAR/endo_const SUBSTRATE n 
addmsg /kinetics/AMPAR/A831*_B831* /kinetics/AMPAR/I_845 SUMTOTAL n nInit 
addmsg /kinetics/AMPAR/A_B831* /kinetics/AMPAR/I_845 SUMTOTAL n nInit 
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addmsg /kinetics/AMPAR/A831*845*_B831* /kinetics/AMPAR/I_845-P SUMTOTAL n nInit 
addmsg /kinetics/AMPAR/A845*_B831* /kinetics/AMPAR/I_845-P SUMTOTAL n nInit 
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addmsg /kinetics/AMPAR/A_B831*845* /kinetics/AMPAR/I_845-P SUMTOTAL n nInit 
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addmsg /kinetics/AMPAR/A_B845* /kinetics/AMPAR/I_845-P SUMTOTAL n nInit 
addmsg /kinetics/AMPAR/A835*845*_B835*845* /kinetics/AMPAR/I_845_PP SUMTOTAL n nInit 
addmsg /kinetics/AMPAR/A845*_B831*845* /kinetics/AMPAR/I_845_PP SUMTOTAL n nInit 
addmsg /kinetics/AMPAR/A831*845*_B845* /kinetics/AMPAR/I_845_PP SUMTOTAL n nInit 
addmsg /kinetics/AMPAR/A845*_B845* /kinetics/AMPAR/I_845_PP SUMTOTAL n nInit 
addmsg /kinetics/AMPAR/I_845 /kinetics/AMPAR/tot_I_GluR12 SUMTOTAL n nInit 
addmsg /kinetics/AMPAR/I_845-P /kinetics/AMPAR/tot_I_GluR12 SUMTOTAL n nInit 
addmsg /kinetics/AMPAR/I_845_PP /kinetics/AMPAR/tot_I_GluR12 SUMTOTAL n nInit 
addmsg /kinetics/AMPAR/tot_I_GluR12 /kinetics/AMPAR/total_Int SUMTOTAL n nInit 
addmsg /kinetics/AMPAR/GluR23_I /kinetics/AMPAR/total_Int SUMTOTAL n nInit 
addmsg /kinetics/PKA/PKA-active/PKA[21] /kinetics/AMPAR/A831*_B845* MM_PRD pA 
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addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[26] /kinetics/AMPAR/A831*_B845* MM_PRD pA 
addmsg /kinetics/PKC-stoch-input /kinetics/PKC-control REAC A B 
addmsg /kinetics/PKC-control /kinetics/PKC-stoch-input SUBSTRATE n 
addmsg /kinetics/PKC-active /kinetics/PKC-stoch-input PRODUCT n 
addmsg /kinetics/Ca_stoch_cyt /kinetics/Ca_control_cyt REAC A B 
addmsg /kinetics/Ca_control_cyt /kinetics/Ca_stoch_cyt SUBSTRATE n 
addmsg /kinetics/Ca /kinetics/Ca_stoch_cyt PRODUCT n 
addmsg /kinetics/Ca_stoch_PSD /kinetics/Ca_control_PSD REAC A B 
addmsg /kinetics/Ca_control_PSD /kinetics/Ca_stoch_PSD SUBSTRATE n 
addmsg /kinetics/Ca-PSD /kinetics/Ca_stoch_PSD PRODUCT n 
addmsg /kinetics/PKA/PKA-active/PKA[3] /kinetics/AMPAR_memb/A_B REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[3] /kinetics/AMPAR_memb/A_B MM_PRD pA 
addmsg /kinetics/PKA/PKA-active/PKA[2] /kinetics/AMPAR_memb/A_B REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[2] /kinetics/AMPAR_memb/A_B MM_PRD pA 
addmsg /kinetics/AMPAR/recycle__ /kinetics/AMPAR_memb/A_B REAC A B 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII[3] /kinetics/AMPAR_memb/A_B REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[11] /kinetics/AMPAR_memb/A_B MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[2] /kinetics/AMPAR_memb/A_B MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[3] /kinetics/AMPAR_memb/A_B MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[23] /kinetics/AMPAR_memb/A_B MM_PRD pA 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII[7] /kinetics/AMPAR_memb/A_B REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[7] /kinetics/AMPAR_memb/A831*_B MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[6] /kinetics/AMPAR_memb/A831*_B MM_PRD pA 
addmsg /kinetics/PKA/PKA-active/PKA[7] /kinetics/AMPAR_memb/A831*_B REAC sA B 
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addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII[3] /kinetics/AMPAR_memb/A831*_B MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[11] /kinetics/AMPAR_memb/A831*_B REAC sA B 
addmsg /kinetics/AMPAR/recycle*_ /kinetics/AMPAR_memb/A831*_B REAC A B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[7] /kinetics/AMPAR_memb/A831*_B MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[6] /kinetics/AMPAR_memb/A831*_B MM_PRD pA 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII[15] /kinetics/AMPAR_memb/A831*_B REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[31] /kinetics/AMPAR_memb/A831*_B MM_PRD pA 
addmsg /kinetics/PKA/PKA-active/PKA[11] /kinetics/AMPAR_memb/A_B831* REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[10] /kinetics/AMPAR_memb/A_B831* REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[14] /kinetics/AMPAR_memb/A_B831* MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[15] /kinetics/AMPAR_memb/A_B831* MM_PRD pA 
addmsg /kinetics/AMPAR/recycle_* /kinetics/AMPAR_memb/A_B831* REAC A B 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII[7] /kinetics/AMPAR_memb/A_B831* MM_PRD pA 
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addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[23] /kinetics/AMPAR_memb/A_B831* REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[27] /kinetics/AMPAR_memb/A_B831* MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[10] /kinetics/AMPAR_memb/A_B831* MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[11] /kinetics/AMPAR_memb/A_B831* MM_PRD pA 
addmsg /kinetics/PKA/PKA-active/PKA[15] /kinetics/AMPAR_memb/A831*_B831* REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[14] /kinetics/AMPAR_memb/A831*_B831* REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[18] /kinetics/AMPAR_memb/A831*_B831* MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[19] /kinetics/AMPAR_memb/A831*_B831* MM_PRD pA 
addmsg /kinetics/AMPAR/recycle** /kinetics/AMPAR_memb/A831*_B831* REAC A B 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII[11] /kinetics/AMPAR_memb/A831*_B831* MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[27] /kinetics/AMPAR_memb/A831*_B831* REAC sA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[14] /kinetics/AMPAR_memb/A831*_B831* MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[15] /kinetics/AMPAR_memb/A831*_B831* MM_PRD pA 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII[15] /kinetics/AMPAR_memb/A831*_B831* MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[31] /kinetics/AMPAR_memb/A831*_B831* REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[1] /kinetics/AMPAR_memb/A845*_B MM_PRD pA 
addmsg /kinetics/PKA/PKA-active/PKA[1] /kinetics/AMPAR_memb/A845*_B REAC sA B 
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addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[2] /kinetics/AMPAR_memb/A845*_B REAC sA B 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII[2] /kinetics/AMPAR_memb/A845*_B REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[10] /kinetics/AMPAR_memb/A845*_B MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[1] /kinetics/AMPAR_memb/A845*_B MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[3] /kinetics/AMPAR_memb/A845*_B REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[22] /kinetics/AMPAR_memb/A845*_B MM_PRD pA 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII[6] /kinetics/AMPAR_memb/A845*_B REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[5] /kinetics/AMPAR_memb/A831*845*_B MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[7] /kinetics/AMPAR_memb/A831*845*_B REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[7] /kinetics/AMPAR_memb/A831*845*_B MM_PRD pA 
addmsg /kinetics/PKA/PKA-active/PKA[5] /kinetics/AMPAR_memb/A831*845*_B REAC sA B 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII[2] /kinetics/AMPAR_memb/A831*845*_B MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[10] /kinetics/AMPAR_memb/A831*845*_B REAC sA B 
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addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[5] /kinetics/AMPAR_memb/A831*845*_B MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[30] /kinetics/AMPAR_memb/A831*845*_B MM_PRD pA 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII[14] /kinetics/AMPAR_memb/A831*845*_B REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[13] /kinetics/AMPAR_memb/A831*845*_B831* REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[15] /kinetics/AMPAR_memb/A831*845*_B831* MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[17] /kinetics/AMPAR_memb/A831*845*_B831* MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[19] /kinetics/AMPAR_memb/A831*845*_B831* REAC sA B 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII[10] /kinetics/AMPAR_memb/A831*845*_B831* MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[26] /kinetics/AMPAR_memb/A831*845*_B831* REAC sA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[13] /kinetics/AMPAR_memb/A831*845*_B831* MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[14] /kinetics/AMPAR_memb/A831*845*_B831* REAC sA B 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII[14] /kinetics/AMPAR_memb/A831*845*_B831* MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[30] /kinetics/AMPAR_memb/A831*845*_B831* REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1 /kinetics/AMPAR_memb/A_B845* MM_PRD pA 
addmsg /kinetics/PKA/PKA-active/PKA /kinetics/AMPAR_memb/A_B845* REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[3] /kinetics/AMPAR_memb/A_B845* REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[3] /kinetics/AMPAR_memb/A_B845* MM_PRD pA 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII[1] /kinetics/AMPAR_memb/A_B845* REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[9] /kinetics/AMPAR_memb/A_B845* MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B /kinetics/AMPAR_memb/A_B845* MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[2] /kinetics/AMPAR_memb/A_B845* REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[20] /kinetics/AMPAR_memb/A_B845* MM_PRD pA 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII[5] /kinetics/AMPAR_memb/A_B845* REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[9] /kinetics/AMPAR_memb/A845*_B831* REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[11] /kinetics/AMPAR_memb/A845*_B831* MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[13] /kinetics/AMPAR_memb/A845*_B831* MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[15] /kinetics/AMPAR_memb/A845*_B831* REAC sA B 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII[6] /kinetics/AMPAR_memb/A845*_B831* MM_PRD pA 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII[10] /kinetics/AMPAR_memb/A845*_B831* REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[22] /kinetics/AMPAR_memb/A845*_B831* REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[26] /kinetics/AMPAR_memb/A845*_B831* MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[9] /kinetics/AMPAR_memb/A845*_B831* MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[11] /kinetics/AMPAR_memb/A845*_B831* REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1 /kinetics/AMPAR_memb/A845*_B845* REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA /kinetics/AMPAR_memb/A845*_B845* MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[1] /kinetics/AMPAR_memb/A845*_B845* REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[1] /kinetics/AMPAR_memb/A845*_B845* MM_PRD pA 
addmsg /kinetics/AMPAR/exo_reg__ /kinetics/AMPAR_memb/A845*_B845* REAC B A 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII /kinetics/AMPAR_memb/A845*_B845* REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[8] /kinetics/AMPAR_memb/A845*_B845* MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B /kinetics/AMPAR_memb/A845*_B845* REAC sA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[1] /kinetics/AMPAR_memb/A845*_B845* REAC sA B 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII[4] /kinetics/AMPAR_memb/A845*_B845* REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[21] /kinetics/AMPAR_memb/A845*_B845* MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[4] /kinetics/AMPAR_memb/A831*_B845* MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[6] /kinetics/AMPAR_memb/A831*_B845* REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[6] /kinetics/AMPAR_memb/A831*_B845* MM_PRD pA 
addmsg /kinetics/PKA/PKA-active/PKA[4] /kinetics/AMPAR_memb/A831*_B845* REAC sA B 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII[1] /kinetics/AMPAR_memb/A831*_B845* MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[9] /kinetics/AMPAR_memb/A831*_B845* REAC sA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[6] /kinetics/AMPAR_memb/A831*_B845* REAC sA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[4] /kinetics/AMPAR_memb/A831*_B845* MM_PRD pA 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII[13] /kinetics/AMPAR_memb/A831*_B845* REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[29] /kinetics/AMPAR_memb/A831*_B845* MM_PRD pA 
addmsg /kinetics/PKA/PKA-active/PKA[8] /kinetics/AMPAR_memb/A_B831*845* REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[10] /kinetics/AMPAR_memb/A_B831*845* MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[12] /kinetics/AMPAR_memb/A_B831*845* MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[14] /kinetics/AMPAR_memb/A_B831*845* REAC sA B 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII[5] /kinetics/AMPAR_memb/A_B831*845* MM_PRD pA 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII[9] /kinetics/AMPAR_memb/A_B831*845* REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[20] /kinetics/AMPAR_memb/A_B831*845* REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[25] /kinetics/AMPAR_memb/A_B831*845* MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[8] /kinetics/AMPAR_memb/A_B831*845* MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[10] /kinetics/AMPAR_memb/A_B831*845* REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[12] /kinetics/AMPAR_memb/A831*_B831*845* REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[14] /kinetics/AMPAR_memb/A831*_B831*845* MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[16] /kinetics/AMPAR_memb/A831*_B831*845* MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[18] /kinetics/AMPAR_memb/A831*_B831*845* REAC sA B 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII[9] /kinetics/AMPAR_memb/A831*_B831*845* MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[25] /kinetics/AMPAR_memb/A831*_B831*845* REAC sA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[12] /kinetics/AMPAR_memb/A831*_B831*845* MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[15] /kinetics/AMPAR_memb/A831*_B831*845* REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[29] /kinetics/AMPAR_memb/A831*_B831*845* REAC sA B 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII[13] /kinetics/AMPAR_memb/A831*_B831*845* MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[4] /kinetics/AMPAR_memb/A831*845*_B845* REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[5] /kinetics/AMPAR_memb/A831*845*_B845* REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[5] /kinetics/AMPAR_memb/A831*845*_B845* MM_PRD pA 
addmsg /kinetics/PKA/PKA-active/PKA[4] /kinetics/AMPAR_memb/A831*845*_B845* MM_PRD pA 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII /kinetics/AMPAR_memb/A831*845*_B845* MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[8] /kinetics/AMPAR_memb/A831*845*_B845* REAC sA B 
addmsg /kinetics/AMPAR/exo_reg*_ /kinetics/AMPAR_memb/A831*845*_B845* REAC B A 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[4] /kinetics/AMPAR_memb/A831*845*_B845* REAC sA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[5] /kinetics/AMPAR_memb/A831*845*_B845* REAC sA B 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII[12] /kinetics/AMPAR_memb/A831*845*_B845* REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[28] /kinetics/AMPAR_memb/A831*845*_B845* MM_PRD pA 
addmsg /kinetics/PKA/PKA-active/PKA[8] /kinetics/AMPAR_memb/A845*_B831*845* MM_PRD pA 
addmsg /kinetics/PKA/PKA-active/PKA[9] /kinetics/AMPAR_memb/A845*_B831*845* MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[12] /kinetics/AMPAR_memb/A845*_B831*845* REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[13] /kinetics/AMPAR_memb/A845*_B831*845* REAC sA B 
addmsg /kinetics/AMPAR/exo_reg_* /kinetics/AMPAR_memb/A845*_B831*845* REAC B A 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII[4] /kinetics/AMPAR_memb/A845*_B831*845* MM_PRD pA 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII[8] /kinetics/AMPAR_memb/A845*_B831*845* REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[21] /kinetics/AMPAR_memb/A845*_B831*845* REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[24] /kinetics/AMPAR_memb/A845*_B831*845* MM_PRD pA 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[8] /kinetics/AMPAR_memb/A845*_B831*845* REAC sA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[9] /kinetics/AMPAR_memb/A845*_B831*845* REAC sA B 
addmsg /kinetics/PKA/PKA-active/PKA[13] /kinetics/AMPAR_memb/A835*845*_B835*845* MM_PRD pA 
addmsg /kinetics/PKA/PKA-active/PKA[12] /kinetics/AMPAR_memb/A835*845*_B835*845* MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[16] /kinetics/AMPAR_memb/A835*845*_B835*845* REAC sA B 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[17] /kinetics/AMPAR_memb/A835*845*_B835*845* REAC sA B 
addmsg /kinetics/AMPAR/exo_reg** /kinetics/AMPAR_memb/A835*845*_B835*845* REAC B A 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII[8] /kinetics/AMPAR_memb/A835*845*_B835*845* MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[24] /kinetics/AMPAR_memb/A835*845*_B835*845* REAC sA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[12] /kinetics/AMPAR_memb/A835*845*_B835*845* REAC sA B 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB/PP2B[13] /kinetics/AMPAR_memb/A835*845*_B835*845* REAC sA B 
addmsg /kinetics/CaMKII/actCaMKII-PSD/CaMKII[12] /kinetics/AMPAR_memb/A835*845*_B835*845* MM_PRD pA 
addmsg /kinetics/PP1_PSD/PP1-active_PSD/PP1[28] /kinetics/AMPAR_memb/A835*845*_B835*845* REAC sA B 
addmsg /kinetics/AMPAR/endo_const /kinetics/AMPAR_memb/GluR23_M REAC A B 
addmsg /kinetics/AMPAR_memb/A845*_B845* /kinetics/AMPAR_memb/Ser845-PP SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A831*845*_B845* /kinetics/AMPAR_memb/Ser845-PP SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A845*_B831*845* /kinetics/AMPAR_memb/Ser845-PP SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A835*845*_B835*845* /kinetics/AMPAR_memb/Ser845-PP SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A845*_B /kinetics/AMPAR_memb/Ser845-P SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A831*845*_B /kinetics/AMPAR_memb/Ser845-P SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A845*_B831* /kinetics/AMPAR_memb/Ser845-P SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A831*845*_B831* /kinetics/AMPAR_memb/Ser845-P SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A_B845* /kinetics/AMPAR_memb/Ser845-P SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A831*_B845* /kinetics/AMPAR_memb/Ser845-P SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A_B831*845* /kinetics/AMPAR_memb/Ser845-P SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A831*_B831*845* /kinetics/AMPAR_memb/Ser845-P SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A_B /kinetics/AMPAR_memb/Ser845 SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A831*_B /kinetics/AMPAR_memb/Ser845 SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A_B831* /kinetics/AMPAR_memb/Ser845 SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A831*_B831* /kinetics/AMPAR_memb/Ser845 SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/Ser845 /kinetics/AMPAR_memb/tot_mem_GluR12 SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/Ser845-P /kinetics/AMPAR_memb/tot_mem_GluR12 SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/Ser845-PP /kinetics/AMPAR_memb/tot_mem_GluR12 SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/GluR23_M /kinetics/AMPAR_memb/total_mem SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/tot_mem_GluR12 /kinetics/AMPAR_memb/total_mem SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A845*_B845* /kinetics/AMPAR_memb/Ser831 SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A_B845* /kinetics/AMPAR_memb/Ser831 SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A845*_B /kinetics/AMPAR_memb/Ser831 SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A_B /kinetics/AMPAR_memb/Ser831 SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A831*845*_B845* /kinetics/AMPAR_memb/Ser831-P SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A845*_B831*845* /kinetics/AMPAR_memb/Ser831-P SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A831*_B845* /kinetics/AMPAR_memb/Ser831-P SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A_B831*845* /kinetics/AMPAR_memb/Ser831-P SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A831*845*_B /kinetics/AMPAR_memb/Ser831-P SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A845*_B831* /kinetics/AMPAR_memb/Ser831-P SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A831*_B /kinetics/AMPAR_memb/Ser831-P SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A_B831* /kinetics/AMPAR_memb/Ser831-P SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A835*845*_B835*845* /kinetics/AMPAR_memb/Ser831-PP SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A831*_B831*845* /kinetics/AMPAR_memb/Ser831-PP SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A831*845*_B831* /kinetics/AMPAR_memb/Ser831-PP SUMTOTAL n nInit 
addmsg /kinetics/AMPAR_memb/A831*_B831* /kinetics/AMPAR_memb/Ser831-PP SUMTOTAL n nInit 
addmsg /kinetics/AMPAR/exo_reg** /kinetics/AMPAR_memb/Anchor REAC A B 
addmsg /kinetics/AMPAR/exo_reg_* /kinetics/AMPAR_memb/Anchor REAC A B 
addmsg /kinetics/AMPAR/exo_reg*_ /kinetics/AMPAR_memb/Anchor REAC A B 
addmsg /kinetics/AMPAR/exo_reg__ /kinetics/AMPAR_memb/Anchor REAC A B 
addmsg /kinetics/AMPAR/recycle__ /kinetics/AMPAR_memb/Anchor REAC B A 
addmsg /kinetics/AMPAR/recycle*_ /kinetics/AMPAR_memb/Anchor REAC B A 
addmsg /kinetics/AMPAR/recycle_* /kinetics/AMPAR_memb/Anchor REAC B A 
addmsg /kinetics/AMPAR/recycle** /kinetics/AMPAR_memb/Anchor REAC B A 
addmsg /kinetics/CaMKII/actCaMKII-PSD /graphs/conc1/actCaMKII-PSD.Co PLOT Co *actCaMKII-PSD.Co *12 
addmsg /kinetics/CaMKII/tot_CaMKII_PSD /graphs/conc1/tot_CaMKII_PSD.Co PLOT Co *tot_CaMKII_PSD.Co *23 
addmsg /kinetics/CaMKII/act_CaMKII_cyt /graphs/conc1/act_CaMKII_cyt.Co PLOT Co *act_CaMKII_cyt.Co *14 
addmsg /kinetics/CaMKII/tot_CaMKII_cyt /graphs/conc1/tot_CaMKII_cyt.Co PLOT Co *tot_CaMKII_cyt.Co *24 
addmsg /kinetics/AMPAR_memb/Ser845-PP /graphs/conc1/Ser845-PP.Co PLOT Co *Ser845-PP.Co *59 
addmsg /kinetics/AMPAR_memb/Ser845-P /graphs/conc1/Ser845-P.Co PLOT Co *Ser845-P.Co *24 
addmsg /kinetics/AMPAR_memb/Ser845 /graphs/conc1/Ser845.Co PLOT Co *Ser845.Co *1 
addmsg /kinetics/AMPAR_memb/Anchor /graphs/conc1/Anchor.Co PLOT Co *Anchor.Co *blue 
addmsg /kinetics/PP2B/CaM_Ca_n-CaNAB /graphs/conc1/CaM_Ca_n-CaNAB.Co PLOT Co *CaM_Ca_n-CaNAB.Co *1 
addmsg /kinetics/AMPAR_memb/tot_mem_GluR12 /graphs/conc2/tot_mem_GluR12.Co PLOT Co *tot_mem_GluR12.Co *blue 
addmsg /kinetics/AMPAR/tot_I_GluR12 /graphs/conc2/tot_I_GluR12.Co PLOT Co *tot_I_GluR12.Co *62 
addmsg /kinetics/AMPAR_memb/Ser831-PP /graphs/conc2/Ser831-PP.Co PLOT Co *Ser831-PP.Co *pink 
addmsg /kinetics/AMPAR_memb/Ser831-P /graphs/conc2/Ser831-P.Co PLOT Co *Ser831-P.Co *53 
addmsg /kinetics/AMPAR_memb/Ser831 /graphs/conc2/Ser831.Co PLOT Co *Ser831.Co *34 
addmsg /kinetics/AMPAR/I_845-P /graphs/conc2/I_845-P.Co PLOT Co *I_845-P.Co *26 
addmsg /kinetics/CaM/CaM-Ca4-PSD /graphs/conc2/CaM-Ca4-PSD.Co PLOT Co *CaM-Ca4-PSD.Co *blue 
addmsg /kinetics/AMPAR/I_845 /graphs/conc2/I_845.Co PLOT Co *I_845.Co *1 
addmsg /kinetics/AMPAR/I_845_PP /graphs/conc2/I_845_PP.Co PLOT Co *I_845_PP.Co *blue 
addmsg /kinetics/PP1_PSD/PP1-active_PSD /moregraphs/conc3/PP1-active_PSD.Co PLOT Co *PP1-active_PSD.Co *cyan 
addmsg /kinetics/PKA/PKA-active /moregraphs/conc3/PKA-active.Co PLOT Co *PKA-active.Co *yellow 
addmsg /kinetics/AC/cAMP /moregraphs/conc3/cAMP.Co PLOT Co *cAMP.Co *green 
addmsg /kinetics/Ca /moregraphs/conc3/Ca.Co PLOT Co *Ca.Co *red 
addmsg /kinetics/PP1/PP1-active /moregraphs/conc4/PP1-active.Co PLOT Co *PP1-active.Co *cyan 
addmsg /kinetics/PKC-active /moregraphs/conc4/PKC-active.Co PLOT Co *PKC-active.Co *red 
addmsg /kinetics/CaM/CaM-Ca4 /moregraphs/conc4/CaM-Ca4.Co PLOT Co *CaM-Ca4.Co *blue 
enddump
// End of dump

call /kinetics/CaMKII/notes LOAD \
"Main reference here is the review by Hanson and Schulman, Ann Rev Biochem" \
"1992 vol 61 pp 559-601. Most of the mechanistic details and a few constants" \
"are derived from there. Many kinetics are from Hanson and Schulman JBC" \
"267:24 17216-17224 1992." \
"The enzs look a terrible mess. Actually it is just 3 reactions for diff sites," \
"by 4 states of CaMKII, defined by the phosph state."
call /kinetics/CaMKII/CaMKII/notes LOAD \
"Huge conc of CaMKII. In PSD it is 20-40% of protein, so we assume it is around" \
"2.5% of protein in spine as a whole. This level is so high it is unlikely to matter" \
"much if we are off a bit. This comes to about 70 uM."
call /kinetics/CaMKII/CaMKII-thr286*-CaM/notes LOAD \
"From Hanson and Schulman, the thr286 is responsible for autonomous activation" \
"of CaMKII."
call /kinetics/CaMKII/CaMKII***/notes LOAD \
"From Hanson and Schulman, the CaMKII does a lot of autophosphorylation" \
"just after the CaM is released. This prevents further CaM binding and renders" \
"the enzyme quite independent of Ca."
call /kinetics/CaMKII/CaMKII-bind-CaM/notes LOAD \
"This is tricky. There is some cooperativity here arising from interactions" \
"between the subunits of the CAMKII holoenzyme. However, the" \
"stoichiometry is 1. " \
"Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994)" \
"so lets say kb = 10. This gives kf = 1.6667e-4" \
"H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high." \
"Low Ca = 100 nM = physiol."
call /kinetics/CaMKII/CaMK-thr286-bind-CaM/notes LOAD \
"Affinity is up 1000X. Time to release is about 20 sec, so the kb is OK at 0.1" \
"This makes Kf around 1.6666e-3" \
""
call /kinetics/CaMKII/CaMKII-thr286/notes LOAD \
"I am not sure if we need to endow this one with a lot of enzs. It is likely" \
"to be a short-lived intermediate, since it will be phosphorylated further" \
"as soon as the CAM falls off."
call /kinetics/CaMKII/tot_CaM_CaMKII/CaM_act_305/notes LOAD \
"Rates from autocamtide phosphorylation, from " \
"Hanson and Schulman JBC 267:24 17216-17224 1992." \
"Jan 1 1998: Speed up 12x to match fig 5."
call /kinetics/CaMKII/tot_autonomous_CaMKII/auton_305/notes LOAD \
"See Hanson and Schulman again, for afterburst rates of" \
"phosph."
call /kinetics/CaMKII/CaMK-thr305/notes LOAD \
"This forms due to basal autophosphorylation, but I think it has to be" \
"considered as a pathway even if some CaM is floating around. In either" \
"case it will tend to block further binding of CaM, and will not display any" \
"enzyme activity. See Hanson and Schulman JBC 267:24 pp17216-17224 1992"
call /kinetics/CaMKII/back_2/notes LOAD \
"Same as for back_1" \
""
call /kinetics/CaMKII/back_1/notes LOAD \
"Rates set by the translocation experiments of " \
"Shen and Meyer, Science 1999."
call /kinetics/CaMKII/transloc_1/notes LOAD \
"Rates to match curve in fig2  from Shen and Meyer, " \
"Science 284:162-166(1999)," \
"calculated for 6:1 alpha:beta CaMKII heterodimers" \
""
call /kinetics/CaMKII/transloc_2/notes LOAD \
"Same as for transloc_1" \
"" \
"" \
""
call /kinetics/CaMKII/NMDAR/notes LOAD \
"The stochiometry is a bit off here. Each NMDAR actually" \
"binds to a holoenzyme, about 12 CaMKII subunits. But" \
"our CaMKII calculations are in terms of individual" \
"subunits. So as a hack, we put in much more NMDAR than" \
"is actually there."
call /kinetics/CaMKII/CaMKII-thr286-bind-CaM-PSD/notes LOAD \
"Same values as for the main compartment" \
"Can the main compartment pool of Ca/CaM be used?"
call /kinetics/CaM/CaM/notes LOAD \
"There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \
"Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \
"it is comparable to CaMK levels. " \
""
call /kinetics/CaM/CaM-TR2-bind-Ca/notes LOAD \
"Lets use the fast rate consts here. Since the rates are so different, I am not" \
"sure whether the order is relevant. These correspond to the TR2C fragment." \
"We use the Martin et al rates here, plus the Drabicowski binding consts." \
"All are scaled by 3X to cell temp." \
"kf = 2e-10 kb = 72" \
"Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \
"If kb=72, kf = 2e-10 (Exactly the same !)...."
call /kinetics/CaM/CaM-TR2-Ca2-bind-Ca/notes LOAD \
"K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \
"kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \
""
call /kinetics/CaM/neurogranin-bind-CaM/notes LOAD \
"Surprisingly, no direct info on rates from neurogranin at this time." \
"These rates are based on GAP-43 binding studies. As GAP-43 and " \
"neurogranin share near identity in the CaM/PKC binding regions, and also" \
"similarity in phosph and dephosph rates, I am borrowing GAP-43 " \
"kinetic info." \
"See Alexander et al JBC 262:13 6108-6113 1987"
call /kinetics/CaM/neurogranin*/notes LOAD \
"The phosph form does not bind CaM (Huang et al ABB 305:2 570-580 1993)"
call /kinetics/CaM/neurogranin/notes LOAD \
"Also known as RC3 and p17 and BICKS." \
"Conc in brain  >> 2 uM from Martzen and Slemmon J neurosci 64 92-100 1995" \
"but others say less without any #s. Conc in dend spines is much higher than " \
"overall, so it could be anywhere from 2 uM to 50. We will estimate" \
"10 uM as a starting point." \
"Gerendasy et al JBC 269:35 22420-22426 1994 have a skeleton model (no" \
"numbers) indicating CaM-Ca(n) binding ...."
call /kinetics/CaM/dephosph-neurogranin/notes LOAD \
"This is put in to keep the basal levels of neurogranin* experimentally" \
"reasonable. From various papers, specially Ramakers et al JBC 270:23 1995" \
"13892-13898," \
" it looks like the basal level of phosph is between 20 and 40%. I est" \
"around 25 % The kf of 0.005 gives around this level at basal PKC" \
"activity levels of 0.1 uM active PKC."
call /kinetics/CaM/CaM-PSD/notes LOAD \
"There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \
"Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \
"it is comparable to CaMK levels. " \
""
call /kinetics/CaM/CaM-TR2-bind-Ca-PSD/notes LOAD \
"Lets use the fast rate consts here. Since the rates are so different, I am not" \
"sure whether the order is relevant. These correspond to the TR2C fragment." \
"We use the Martin et al rates here, plus the Drabicowski binding consts." \
"All are scaled by 3X to cell temp." \
"kf = 2e-10 kb = 72" \
"Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \
"If kb=72, kf = 2e-10 (Exactly the same !)...."
call /kinetics/CaM/CaM-TR2-Ca2-bind-Ca-PSD/notes LOAD \
"K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \
"kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \
""
call /kinetics/CaM/CaM-Ca3-bind-Ca-PSD/notes LOAD \
"Use K3 = 21.5 uM here from Stemmer and Klee table 3." \
"kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10"
call /kinetics/CaM/neurogranin_PSD/notes LOAD \
"Also known as RC3 and p17 and BICKS." \
"Conc in brain  >> 2 uM from Martzen and Slemmon J neurosci 64 92-100 1995" \
"but others say less without any #s. Conc in dend spines is much higher than " \
"overall, so it could be anywhere from 2 uM to 50. We will estimate" \
"10 uM as a starting point." \
"Gerendasy et al JBC 269:35 22420-22426 1994 have a skeleton model (no" \
"numbers) indicating CaM-Ca(n) binding ...."
call /kinetics/CaM/neurogranin-bind-CaM_PSD/notes LOAD \
"Surprisingly, no direct info on rates from neurogranin at this time." \
"These rates are based on GAP-43 binding studies. As GAP-43 and " \
"neurogranin share near identity in the CaM/PKC binding regions, and also" \
"similarity in phosph and dephosph rates, I am borrowing GAP-43 " \
"kinetic info." \
"See Alexander et al JBC 262:13 6108-6113 1987"
call /kinetics/CaM/dephosph-neurogranin_PSD/notes LOAD \
"This is put in to keep the basal levels of neurogranin* experimentally" \
"reasonable. From various papers, specially Ramakers et al JBC 270:23 1995" \
"13892-13898," \
" it looks like the basal level of phosph is between 20 and 40%. I est" \
"around 25 % The kf of 0.005 gives around this level at basal PKC" \
"activity levels of 0.1 uM active PKC."
call /kinetics/CaM/neurogranin*_PSD/notes LOAD \
"The phosph form does not bind CaM (Huang et al ABB 305:2 570-580 1993)"
call /kinetics/CaM/CaM-TR2-Ca2/notes LOAD \
"This is the intermediate where the TR2 end (the high-affinity end) has" \
"bound the Ca but the TR1 end has not."
call /kinetics/CaM/CaM-Ca3-bind-Ca/notes LOAD \
"Use K3 = 21.5 uM here from Stemmer and Klee table 3." \
"kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10"
call /kinetics/CaM/CaM-TR2-Ca2-PSD/notes LOAD \
"This is the intermediate where the TR2 end (the high-affinity end) has" \
"bound the Ca but the TR1 end has not."
call /kinetics/CaM/equilib/notes LOAD \
"Diffusional equilibrium between PSD- and cytosolic compartment." \
"According to D. Bary in Cell Movements 2nd ed 2001 D for proteins" \
"is 5e-7 cm^2/s giving 10 ms for a translocation of 1 um.  "
call /kinetics/PP1/I1/notes LOAD \
"I1 is a 'mixed' inhibitor, but at high enz concs it looks like a non-compet" \
"inhibitor (Foulkes et al Eur J Biochem 132 309-313 9183)." \
"We treat it as non-compet, so it just turns the enz off" \
"without interacting with the binding site." \
"Cohen et al ann rev bioch refer to results where conc is " \
"1.5 to 1.8 uM. In order to get complete inhib of PP1, which is at 1.8 uM," \
"we need >= 1.8 uM." \
"" \
""
call /kinetics/PP1/I1*/notes LOAD \
"Dephosph is mainly by PP2B"
call /kinetics/PP1/Inact-PP1/notes LOAD \
"K inhib = 1nM from Cohen Ann Rev Bioch 1989, " \
"4 nM from Foukes et al " \
"Assume 2 nM. kf /kb = 8.333e-4"
call /kinetics/PP1/dissoc-PP1-I1/notes LOAD \
"Let us assume that the equil in this case is very far over to the" \
"right. This is probably safe." \
""
call /kinetics/PP1/PP2A/PP2A-dephosph-I1/notes LOAD \
"PP2A does most of the dephosph of I1 at basal Ca levels. See" \
"the review by Cohen in Ann Rev Biochem 1989." \
"For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6" \
""
call /kinetics/PP1/PP2A/PP2A-dephosph-PP1-I*/notes LOAD \
"k1 changed from 3.3e-6 to 6.6e-6" \
""
call /kinetics/PP1/PP2A/PP2A-dephosph-I1_PSD/notes LOAD \
"PP2A does most of the dephosph of I1 at basal Ca levels. See" \
"the review by Cohen in Ann Rev Biochem 1989." \
"For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6" \
""
call /kinetics/PP1/PP2A/PP2A-dephosph-PP1-I*_PSD/notes LOAD \
"k1 changed from 3.3e-6 to 6.6e-6" \
""
call /kinetics/PP1/PP1-active/notes LOAD \
"Cohen et al Meth Enz 159 390-408 is main source of info" \
"conc  = 1.8 uM"
call /kinetics/PP2B/notes LOAD \
"Also called Calcineurin." \
"Major sources of info:" \
"Cohen, P Ann Rev Biochem 1989 58:453-508" \
"Mumby and Walker Physiol Rev 73:4 673-699" \
"Stemmer and Klee Biochem 33 1994 6859-6866" \
"Liu and Storm JBC 264:22 1989 12800-12804" \
"This model is unusual: There is actually more expt info than I want to" \
"put in the model at this time." \
"Phosph: Hashimoto and Soderling JBC 1989 264:28 16624-16629 (Not used)"
call /kinetics/PP2B/CaNAB/notes LOAD \
"We assume that the A and B subunits of PP2B are always bound under" \
"physiol conditions." \
"Up to 1% of brain protein = 25 uM. I need to work out how it is distributed" \
"between cytosolic and particulate fractions." \
"Tallant and Cheung '83 Biochem 22 3630-3635 have conc in many " \
"species, average for mammalian brain is around 1 uM."
call /kinetics/PP2B/Ca-bind-CaNAB-Ca2/notes LOAD \
"This process is probably much more complicated and involves CaM." \
"However, as I can't find detailed info I am bundling this into a" \
"single step." \
"Based on Steemer and Klee pg 6863, the Kact is 0.5 uM." \
"kf/kb = 1/(0.5 * 6e5)^2 = 1.11e-11"
call /kinetics/PP2B/Ca-bind-CaNAB/notes LOAD \
"going on the experience with CaM, we put the fast (high affinity)" \
"sites first. We only know (Stemmer and Klee) that the affinity is < 70 nM." \
"Assuming 10 nM at first, we get" \
"kf = 2.78e-8, kb = 1." \
"Try 20 nM." \
"kf = 7e-9, kb = 1" 
call /kinetics/PP2B/CaNAB-Ca4/dephosph_inhib1_noCaM/notes LOAD \
"The rates here are so slow I do not know if we should even bother" \
"with this enz reacn. These numbers are from Liu and Storm." \
"Other refs suggest that the Km stays the same" \
"but the Vmax goes to 10% of the CaM stim levels. " \
"Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013" \
"New : k1=5.7e-8, k2=.136, k3=.034"
call /kinetics/PP2B/CaNAB-Ca4/dephosph_inhib1_noCaM_PSD/notes LOAD \
"The rates here are so slow I do not know if we should even bother" \
"with this enz reacn. These numbers are from Liu and Storm." \
"Other refs suggest that the Km stays the same" \
"but the Vmax goes to 10% of the CaM stim levels. " \
"Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013" \
"New : k1=5.7e-8, k2=.136, k3=.034"
call /kinetics/PP2B/CaM_Ca_n-CaNAB/dephosph_neurogranin/notes LOAD \
"From Seki et al ABB 316(2):673-679"
call /kinetics/PP2B/CaM_Ca_n-CaNAB/dephosph_neurogranin_PSD/notes LOAD \
"From Seki et al ABB 316(2):673-679"
call /kinetics/PKA/notes LOAD \
"General ref: Taylor et al Ann Rev Biochem 1990 59:971-1005" \
""
call /kinetics/PKA/R2C2/notes LOAD \
"This is the R2C2 complex, consisting of 2 catalytic (C)" \
"subunits, and the R-dimer. See Taylor et al Ann Rev Biochem" \
"1990 59:971-1005 for a review." \
"The Doskeland and Ogreid review is better for numbers." \
"Amount of PKA is about .5 uM."
call /kinetics/PKA/R2C2-cAMP/notes LOAD \
"CoInit was .0624" \
""
call /kinetics/PKA/cAMP-bind-site-B1/notes LOAD \
"Hasler et al FASEB J 6:2734-2741 1992 say Kd =1e-7M" \
"for type II, 5.6e-8 M for type I. Take mean" \
"which comes to 2e-13 #/cell" \
"Smith et al PNAS USA 78:3 1591-1595 1981 have better data." \
"First kf/kb=2.1e7/M = 3.5e-5 (#/cell)." \
"Ogreid and Doskeland Febs Lett 129:2 287-292 1981 have figs" \
"suggesting time course of complete assoc is < 1 min."
call /kinetics/PKA/cAMP-bind-site-B2/notes LOAD \
"For now let us set this to the same Km (1e-7M) as" \
"site B. This gives kf/kb = .7e-7M * 1e6 / (6e5^2) : 1/(6e5^2)" \
"= 2e-13:2.77e-12" \
"Smith et al have better values. They say that this is" \
"cooperative, so the consts are now kf/kb =8.3e-4"
call /kinetics/PKA/R2-cAMP4/notes LOAD \
"Starts at 0.15 for the test of fig 6 in Smith et al, but we aren't using" \
"that paper any more."
call /kinetics/PKA/Release-C1/notes LOAD \
"This has to be fast, as the activation of PKA by cAMP" \
"is also fast." \
"kf was 10" \
""
call /kinetics/PKA/PKA-inhibitor/notes LOAD \
"About 25% of PKA C subunit is dissociated in resting cells without" \
"having any noticable activity." \
"Doskeland and Ogreid Int J biochem 13 pp1-19 suggest that this is" \
"because there is a corresponding amount of inhibitor protein."
call /kinetics/PKA/inhib-PKA/notes LOAD \
"This has to be set to zero for matching the expts in vitro. In vivo" \
"we need to consider the inhibition though." \
"kf = 1e-5" \
"kb = 1" \
""
call /kinetics/PKA/PKA-active/phosph-PDE/notes LOAD \
"Same rates as PKA-phosph-I1"
call /kinetics/PKA/PKA-active/PKA-phosph-I1/notes LOAD \
"#s from Bramson et al CRC crit rev Biochem" \
"15:2 93-124. They have a huge list of peptide substrates" \
"and I have chosen high-ish rates." \
"These consts give too much PKA activity, so lower Vmax 1/3." \
"Now, k1 = 3e-5, k2 = 36, k3 = 9 (still pretty fast)." \
"Also lower Km 1/3  so k1 = 1e-5" \
"Cohen et al FEBS Lett 76:182-86 1977 say rate =30% PKA act on " \
"phosphokinase beta." \
""
call /kinetics/AC/ATP/notes LOAD \
"ATP is present in all cells between 2 and 10 mM. See Lehninger" \
""
call /kinetics/AC/AC1-CaM/notes LOAD \
"This version of cyclase is Calmodulin activated." \
"Gs stims it but betagamma inhibits."
call /kinetics/AC/AC1-CaM/kenz/notes LOAD \
"17 Feb 2005" \
"Halved Vmax as the amount of enzyme has been doubled to" \
"get an integer value in the spine." \
"18 Feb 2005. Updated Km from BRENDA: EC No 4.6.1.1" \
"Rat Km: 0.95 mM    Turnover 12/sec." \
"Human Km: 0.3 mM" \
"" \
"12 umol/min/mg for mammalia, turnover is 12/sec" \
"See PMID 8663304 by Dessauer and Gilman JBC 271 1996" \
"" \
"Unfortunately turnover range is from 34 down to 0.1" \
"in different studies, according to BRENDA." \
""
call /kinetics/AC/AC1/notes LOAD \
"Starting conc at 20 nM." \
"Reduced conc to 10 nM, 14.8. Arnold" \
"17 Feb 2005. Raised conc back to about 18 nM, for an " \
"nInit of precisely 1." \
"18 Feb. Doubled conc, to compensate for reduced ATP." \
"18 Feb. Doublec conc again, halved Vmax."
call /kinetics/AC/CaM-bind-AC1/notes LOAD \
"Half-max at 20 nM CaM (Tang et al JBC 266:13 8595-8603 1991" \
"kb/kf = 20 nM = 12000 #/cell" \
"so kf = kb/12000 = kb * 8.333e-5" \
""
call /kinetics/AC/AC2*/notes LOAD \
"This version is activated by Gs and by a betagamma and phosphorylation."
call /kinetics/AC/AC2*/kenz/notes LOAD \
"Reduced Km to match expt data for basal activation of AC2 by PKC." \
"Now k1 = 2.9e-6, k2 = 72, k3 = 18" \
"" \
"18 Feb: Raised Km to 300 based on BRENDA data." \
"Unlikely to make much difference, given the vast amount" \
"of ATP."
call /kinetics/AC/AC2/notes LOAD \
"Starting at 0.015 uM." \
"17 Feb 2005: Raised slightly so as to have integer" \
"number of molecules." \
"18 Feb 2005: Doubled, to compensate for reduced ATP."
call /kinetics/AC/dephosph-AC2/notes LOAD \
"Random rate."
call /kinetics/AC/cAMP-PDE/notes LOAD \
"The levels of the PDE are not known at this time. However," \
"enough" \
"kinetic info and info about steady-state levels of cAMP" \
"etc are around" \
"to make it possible to estimate this." \
"18 Feb 2005: After some playing with initial conc, it is" \
"now back at 0.5 uM."
call /kinetics/AC/cAMP-PDE/PDE/notes LOAD \
"Best rates are from Conti et al Biochem 34 7979-7987 1995." \
"Though these" \
"are for the Sertoli cell form, it looks like they carry" \
"nicely into" \
"alternatively spliced brain form. See Sette et al" \
"JBC 269:28 18271-18274" \
"Km ~2 uM, Vmax est ~ 10 umol/min/mg for pure form." \
"Brain protein is 93 kD but this was 67." \
"So k3 ~10, k2 ~40, k1 ~4.2e-6"
call /kinetics/AC/cAMP-PDE*/notes LOAD \
"This form has about 2X activity as plain PDE. See Sette et al JBC 269:28" \
"18271-18274 1994."
call /kinetics/AC/cAMP-PDE*/PDE*/notes LOAD \
"This form has about twice the activity of the unphosphorylated form. See" \
"Sette et al JBC 269:28 18271-18274 1994." \
"We'll ignore cGMP effects for now."
call /kinetics/AC/dephosph-PDE/notes LOAD \
"The rates for this are poorly constrained. In adipocytes (probably a" \
"different PDE) the dephosphorylation is complete within 15 min, but" \
"there are no intermediate time points so it could be much faster. Identity" \
"of phosphatase etc is still unknown."
call /kinetics/AC/PDE1/notes LOAD \
"CaM-Dependent PDE. Amount calculated from total rate in" \
"brain vs. specific rate. "
call /kinetics/AC/PDE1/PDE1/notes LOAD \
"Rate is 1/6 of the CaM stim form. We'll just reduce" \
"all lf k1, k2, k3 so that the Vmax goes down 1/6."
call /kinetics/AC/CaM.PDE1/notes LOAD \
"Activity up 6x following Ca-CaM binding."
call /kinetics/AC/CaM.PDE1/CaM.PDE1/notes LOAD \
"Max activity ~10umol/min/mg in presence of lots of CaM." \
"Affinity is low, 40 uM." \
"k3 = 10, k2 = 40, k1 = (50/40) / 6e5."
call /kinetics/AC/CaM_bind_PDE1/notes LOAD \
"For olf epi PDE1, affinity is 7 nM. Assume same for brain." \
"Reaction should be pretty fast. Assume kb = 5/sec." \
"Then kf = 5 / (0.007 * 6e5) = 1.2e-3"
call /kinetics/AC/cAMP_in_dend/notes LOAD \
"Assume a 5 uM long segment of 1 uM^2 Xsection dendrite." \
""
call /kinetics/AC/cAMP_diffusion/notes LOAD \
"Represents diffusion, from a volume of 9e-20 to 5e-18." \
"Assuming neck dimensions of 0.1 x 0.1 microns, this" \
"works out to a diffusion const of about " \
"270 um^2/sec, which is pretty conservative. It is what" \
"cAMP does in frog cilia." \
""
call /kinetics/AC/cAMP/notes LOAD \
"The conc of this has been a problem. Schaecter and Benowitz use 50 uM," \
"but Shinomura et al have < 5. So I have altered the cAMP-dependent " \
"rates in the PKA model to reflect this."
call /kinetics/PP1_PSD/I1/notes LOAD \
"I1 is a 'mixed' inhibitor, but at high enz concs it looks like a non-compet" \
"inhibitor (Foulkes et al Eur J Biochem 132 309-313 9183)." \
"We treat it as non-compet, so it just turns the enz off" \
"without interacting with the binding site." \
"Cohen et al ann rev bioch refer to results where conc is " \
"1.5 to 1.8 uM. In order to get complete inhib of PP1, which is at 1.8 uM," \
"we need >= 1.8 uM." \
"" \
""
call /kinetics/PP1_PSD/I1*/notes LOAD \
"Dephosph is mainly by PP2B"
call /kinetics/PP1_PSD/dissoc-PP1-I1/notes LOAD \
"Let us assume that the equil in this case is very far over to the" \
"right. This is probably safe." \
""
call /kinetics/PP1_PSD/PP1-active_PSD/notes LOAD \
"Cohen et al Meth Enz 159 390-408 is main source of info" \
"conc  = 1.8 uM"
call /kinetics/PP1_PSD/Inact-PP1/notes LOAD \
"K inhib = 1nM from Cohen Ann Rev Bioch 1989, " \
"4 nM from Foukes et al " \
"Assume 2 nM. kf /kb = 8.333e-4"
call /kinetics/PKC-active/PKC-phosph-neurogranin/notes LOAD \
"Rates from Huang et al ABB 305:2 570-580 1993"
call /kinetics/PKC-active/PKC-phosph-ng-CaM/notes LOAD \
"Rates are 60% those of PKC-phosph-neurogranin. See" \
"Huang et al ABB 305:2 570-580 1993"
call /kinetics/PKC-active/phosph-AC2/notes LOAD \
"Phorbol esters have little effect on AC1 or on the Gs-stimulation of" \
"AC2. So in this model we are only dealing with the increase in" \
"basal activation of AC2 induced by PKC" \
"k1 = 1.66e-6" \
"k2 = 16" \
"k3 =4" \
""
call /kinetics/PKC-active/PKC-phosph-neurogranin_PSD/notes LOAD \
"Rates from Huang et al ABB 305:2 570-580 1993"
call /kinetics/PKC-active/PKC-phosph-ng-CaM_PSD/notes LOAD \
"Rates are 60% those of PKC-phosph-neurogranin. See" \
"Huang et al ABB 305:2 570-580 1993"
call /kinetics/AMPAR/exo_reg__/notes LOAD \
"Exo rates are scaled from earlier model versions to " \
"account for binding of anchor. We have about 200 molecules" \
"of anchor in the whole model." \
"Here we select rates to give us a max of about 150 molecules" \
"of GluR at the synapse."
call /kinetics/doqcsinfo/notes LOAD \
"This is model 0 from Hayer and Bhalla, PLoS Comput Biol 2005." \
"It has a bistable model of AMPAR traffic, plus a non-bistable" \
"model of CaMKII. This differs from the reference model (model 1)" \
"in that model0 lacks degradation and turnover reactions for AMPAR."
complete_loading