//genesis // kkit Version 11 flat dumpfile // Saved on Fri Dec 8 15:24:07 2006 include kkit {argv 1} FASTDT = 1e-05 SIMDT = 0.001 CONTROLDT = 10 PLOTDT = 1 MAXTIME = 2000 TRANSIENT_TIME = 2 VARIABLE_DT_FLAG = 1 DEFAULT_VOL = 1.2566e-16 VERSION = 11.0 setfield /file/modpath value /home2/bhalla/scripts/modules kparms //genesis initdump -version 3 -ignoreorphans 1 simobjdump doqcsinfo filename accessname accesstype transcriber developer \ citation species tissue cellcompartment methodology sources \ model_implementation model_validation x y z simobjdump table input output alloced step_mode stepsize x y z simobjdump xtree path script namemode sizescale simobjdump xcoredraw xmin xmax ymin ymax simobjdump xtext editable simobjdump xgraph xmin xmax ymin ymax overlay simobjdump xplot pixflags script fg ysquish do_slope wy simobjdump group xtree_fg_req xtree_textfg_req plotfield expanded movealone \ link savename file version md5sum mod_save_flag x y z simobjdump geometry size dim shape outside xtree_fg_req xtree_textfg_req x y \ z simobjdump kpool DiffConst CoInit Co n nInit mwt nMin vol slave_enable \ geomname xtree_fg_req xtree_textfg_req x y z simobjdump kreac kf kb notes xtree_fg_req xtree_textfg_req x y z simobjdump kenz CoComplexInit CoComplex nComplexInit nComplex vol k1 k2 k3 \ keepconc usecomplex notes xtree_fg_req xtree_textfg_req link x y z simobjdump stim level1 width1 delay1 level2 width2 delay2 baselevel trig_time \ trig_mode notes xtree_fg_req xtree_textfg_req is_running x y z simobjdump xtab input output alloced step_mode stepsize notes editfunc \ xtree_fg_req xtree_textfg_req baselevel last_x last_y is_running x y z simobjdump kchan perm gmax Vm is_active use_nernst notes xtree_fg_req \ xtree_textfg_req x y z simobjdump transport input output alloced step_mode stepsize dt delay clock \ kf xtree_fg_req xtree_textfg_req x y z simobjdump proto x y z simundump geometry /kinetics/dendgeom 0 1.5e-18 3 cylinder "" white black 8 \ -2 0 simundump group /kinetics/PKC 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0 0 "" red hotpink "" 66 17 0 simundump kreac /kinetics/chain/kinetics[1]/Ras/inact-GEF/diff 0 0.001 0.001 \ "" white black 67.453 21.352 0 simundump kpool /kinetics/chain/kinetics[1]/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 60.448 17.246 0 simundump kenz /kinetics/chain/kinetics[1]/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 \ 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 61.085 16.086 0 simundump kreac /kinetics/chain/kinetics[1]/Ras/GEF*/diff 0 0.001 0.001 "" \ white black 61.448 20.246 0 simundump kpool /kinetics/chain/kinetics[1]/Ras/GTP-Ras 1 0 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange blue 66.564 13.084 0 simundump kpool /kinetics/chain/kinetics[1]/Ras/GDP-Ras 1 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink blue 60.131 14.165 0 simundump kreac /kinetics/chain/kinetics[1]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 63.098 13.5 0 simundump kreac /kinetics/chain/kinetics[1]/Ras/dephosph-GAP 1 0.1 0 "" white \ blue 58.023 15.524 0 simundump kpool /kinetics/chain/kinetics[1]/Ras/GAP* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red blue 55.35 14.349 0 simundump kreac /kinetics/chain/kinetics[1]/Ras/GAP*/diff 0 0.001 0.001 "" \ white black 56.35 17.349 0 simundump kpool /kinetics/chain/kinetics[1]/Ras/GAP 1 -1e-12 0.01 0.01 753.96 \ 753.96 0 0 75396 0 /kinetics/dendgeom red blue 60.655 12.338 0 simundump kenz /kinetics/chain/kinetics[1]/Ras/GAP/GAP-inact-ras 1 0 0 0 0 \ 75396 0.00065634 40 10 0 0 "" red red "" 63.012 12.403 0 simundump kreac /kinetics/chain/kinetics[1]/Ras/GAP/diff 0 0.001 0.001 "" \ white black 61.655 15.338 0 simundump kreac /kinetics/chain/kinetics[1]/Ras/CaM-bind-GEF 1 0.0026526 1 "" \ white blue 56.486 21.679 0 simundump kpool /kinetics/chain/kinetics[1]/Ras/CaM-GEF 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 59.345 19.58 0 simundump kenz /kinetics/chain/kinetics[1]/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 \ 0 0 75396 2.6261e-05 0.8 0.2 0 0 "" red pink "" 59.022 18.657 0 simundump kreac /kinetics/chain/kinetics[1]/Ras/CaM-GEF/diff 0 0.001 0.001 "" \ white black 60.345 22.58 0 simundump group /kinetics/chain/kinetics[1]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 44 21 0 simundump kpool /kinetics/chain/kinetics[1]/CaM/CaM 1 -1e-12 20 20 1.5079e+06 \ 1.5079e+06 0 0 75396 0 /kinetics/dendgeom pink blue 41 30 0 simundump kreac /kinetics/chain/kinetics[1]/CaM/CaM/diff 0 0.001 0.001 "" \ white black 42 33 0 simundump kreac /kinetics/chain/kinetics[1]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 43.6 23.26 0 simundump kpool /kinetics/chain/kinetics[1]/CaM/CaM-Ca3 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 47.489 24.397 0 simundump kreac /kinetics/chain/kinetics[1]/CaM/CaM-Ca3/diff 0 0.001 0.001 "" \ white black 48.489 27.397 0 simundump kpool /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom blue blue 52 24 0 simundump kreac /kinetics/chain/kinetics[1]/CaM/CaM-Ca4/diff 0 0.001 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0.001 0.001 "" white \ black 37 26 0 simundump kreac /kinetics/chain/kinetics[1]/Ras-act-unphosph-raf 0 0 0 "" \ white black 58 8 0 simundump group /kinetics/chain/kinetics[1]/PKM 0 25 black x 0 0 "" PKM \ defaultfile.g 0 5dc016e940e88c1cc7928f4e096ff523 0 47 19 0 simundump kpool /kinetics/chain/kinetics[1]/PKM/Ca_detector 0 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom 7 25 43 17 0 simundump kreac /kinetics/chain/kinetics[1]/PKM/Ca_detector/diff 0 0.001 \ 0.001 "" white black 44 20 0 simundump kpool /kinetics/chain/kinetics[1]/PKM/PKM_synthesis 0 -1e-12 0.001 \ 0.001 75.396 75.396 0 0 75396 0 /kinetics/dendgeom 8 25 43 9 0 simundump kenz /kinetics/chain/kinetics[1]/PKM/PKM_synthesis/kenz 0 0 0 0 0 \ 75396 3.3159e-07 0.2 0.05 0 0 "" red 8 "" 44 10 0 simundump kreac /kinetics/chain/kinetics[1]/PKM/PKM_synthesis/diff 0 0.001 \ 0.001 "" white black 44 12 0 simundump kpool /kinetics/chain/kinetics[1]/PKM/AA_pool 0 -1e-12 1 1 75396 \ 75396 0 0 75396 4 /kinetics/dendgeom 9 25 47 12 0 simundump kreac /kinetics/chain/kinetics[1]/PKM/PKM_degradation 0 0.0005 0 "" \ white 25 46 7 0 simundump kpool /kinetics/chain/kinetics[1]/PKM/degraded_PKM 0 -1e-12 0 0 0 0 \ 0 0 75396 4 /kinetics/dendgeom 7 25 42 5 0 simundump kpool /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex 0 -1e-12 \ 0 0 0 0 0 0 75396 0 /kinetics/dendgeom 7 25 42 14 0 simundump kenz /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex/kenz 0 0 0 \ 0 0 75396 2.6526e-06 0.8 0.2 0 0 "" red 7 "" 42 13 0 simundump kreac /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex/diff 0 \ 0.001 0.001 "" white black 43 17 0 simundump kpool /kinetics/chain/kinetics[1]/PKM/PKM_activator 0 -1e-12 0.2 \ 0.2 15079 15079 0 0 75396 0 /kinetics/dendgeom 6 25 39 12 0 simundump kreac /kinetics/chain/kinetics[1]/PKM/PKM_activator/diff 0 0.001 \ 0.001 "" white black 40 15 0 simundump kreac /kinetics/chain/kinetics[1]/PKM/turn_off_activator 0 0.001 0 \ "" white 25 37 9 0 simundump kreac /kinetics/chain/kinetics[1]/PKM/trigger_PKM 0 0.00013263 1 "" \ white 25 37 16 0 simundump kpool /kinetics/chain/kinetics[1]/Ca_input 0 0 0.08 0.08 6031.7 \ 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 36 30 0 simundump kreac /kinetics/chain/kinetics[1]/Ca_diff 0 5 5 "" white black 36 \ 26 0 simundump group /kinetics/chain/kinetics[2] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 104 0 0 simundump group /kinetics/chain/kinetics[2]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 100.95 8.2163 0 simundump kpool /kinetics/chain/kinetics[2]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 99.925 1.5108 0 simundump kreac /kinetics/chain/kinetics[2]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 100.93 4.5108 0 simundump kreac /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca 0 7.958e-06 0.5 \ "" white blue 99.925 -0.12295 0 simundump kreac /kinetics/chain/kinetics[2]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 101.94 0.69395 0 simundump kreac 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simundump group /kinetics/chain/kinetics[2]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 119 11 0 simundump kpool /kinetics/chain/kinetics[2]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 110 8 0 simundump kpool /kinetics/chain/kinetics[2]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 113 8 0 simundump kpool /kinetics/chain/kinetics[2]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 110 4 0 simundump kpool /kinetics/chain/kinetics[2]/MAPK/MAPK 0 -1e-12 3.5999 3.5999 \ 2.7142e+05 2.7142e+05 0 0 75396 0 /kinetics/dendgeom pink brown 110 1 0 simundump kreac /kinetics/chain/kinetics[2]/MAPK/MAPK/diff 0 0.001 0.001 "" \ white black 111 4 0 simundump kpool /kinetics/chain/kinetics[2]/MAPK/craf-1** 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink brown 116 8 0 simundump kpool /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr 1 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange brown 113 1 0 simundump kreac /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr/diff 0 0.001 0.001 \ "" white black 114 4 0 simundump kpool /kinetics/chain/kinetics[2]/MAPK/MAPKK* 0 0 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom pink brown 117 4 0 simundump kenz /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 112 3 0 simundump kenz /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 117 3 0 simundump kpool /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 113 4 0 simundump kpool /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 109 6 0 simundump kenz /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 0 \ 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 112 6 0 simundump kenz /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 0 \ 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 115 6 0 simundump kpool /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red brown 109 5 0 simundump kenz /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 112 5 0 simundump kenz /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 115 5 0 simundump kpool /kinetics/chain/kinetics[2]/MKP-1 1 -1e-12 0.02 0.02 1507.9 \ 1507.9 0 0 75396 0 /kinetics/dendgeom hotpink black 109 2 0 simundump kenz /kinetics/chain/kinetics[2]/MKP-1/MKP1-tyr-deph 1 0 0 0 0 \ 75396 3.7895e-05 16 4 0 0 "" red hotpink "" 110 3 0 simundump kenz /kinetics/chain/kinetics[2]/MKP-1/MKP1-thr-deph 1 0 0 0 0 \ 75396 3.7895e-05 16 4 0 0 "" red hotpink "" 115 3 0 simundump kreac /kinetics/chain/kinetics[2]/MKP-1/diff 0 0.001 0.001 "" white \ black 110 5 0 simundump kreac /kinetics/chain/kinetics[2]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 107 9 0 simundump kpool /kinetics/chain/kinetics[2]/PPhosphatase2A 1 -1e-12 1 1 75396 \ 75396 0 0 75396 0 /kinetics/dendgeom hotpink yellow 113 9 0 simundump kenz /kinetics/chain/kinetics[2]/PPhosphatase2A/craf-deph 1 0 0 0 0 \ 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 112 10 0 simundump kenz /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 115 7 0 simundump kenz /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph-ser 1 0 \ 0 0 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 112 7 0 simundump kenz /kinetics/chain/kinetics[2]/PPhosphatase2A/craf**-deph 1 0 0 0 \ 0 0.12566 2.5414e-05 24 6 0 0 "" red hotpink "" 116 10 0 simundump kreac /kinetics/chain/kinetics[2]/PPhosphatase2A/diff 0 0.001 0.001 \ "" white black 114 12 0 simundump group /kinetics/chain/kinetics[2]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 118.51 16.351 0 simundump kreac /kinetics/chain/kinetics[2]/Ras/dephosph-GEF 1 1 0 "" white \ blue 113.07 17.881 0 simundump kpool /kinetics/chain/kinetics[2]/Ras/inact-GEF 1 -1e-12 0.1 0.1 \ 7539.6 7539.6 0 0 75396 0 /kinetics/dendgeom hotpink blue 116.45 18.352 0 simundump kenz /kinetics/chain/kinetics[2]/Ras/inact-GEF/basal_GEF_activity 0 \ 0 0 0 0 75396 1.313e-07 0.08 0.02 0 0 "" red hotpink "" 116 17 0 simundump kreac /kinetics/chain/kinetics[2]/Ras/inact-GEF/diff 0 0.001 0.001 \ "" white black 117.45 21.352 0 simundump kpool /kinetics/chain/kinetics[2]/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 110.45 17.246 0 simundump kenz /kinetics/chain/kinetics[2]/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 \ 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 111.09 16.086 0 simundump kreac /kinetics/chain/kinetics[2]/Ras/GEF*/diff 0 0.001 0.001 "" \ white black 111.45 20.246 0 simundump kpool /kinetics/chain/kinetics[2]/Ras/GTP-Ras 1 0 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange blue 116.56 13.084 0 simundump kpool /kinetics/chain/kinetics[2]/Ras/GDP-Ras 1 0 0.5 0.5 37698 \ 37698 0 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0 /kinetics/dendgeom 6 25 239 12 0 simundump kreac /kinetics/chain/kinetics[5]/PKM/PKM_activator/diff 0 0.001 \ 0.001 "" white black 240 15 0 simundump kreac /kinetics/chain/kinetics[5]/PKM/turn_off_activator 0 0.001 0 \ "" white 25 237 9 0 simundump kreac /kinetics/chain/kinetics[5]/PKM/trigger_PKM 0 0.00013263 1 "" \ white 25 237 16 0 simundump kpool /kinetics/chain/kinetics[5]/Ca_input 0 0 0.08 0.08 6031.7 \ 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 236 30 0 simundump kreac /kinetics/chain/kinetics[5]/Ca_diff 0 5 5 "" white black 236 \ 26 0 simundump group /kinetics/chain/kinetics[6] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 304 0 0 simundump group /kinetics/chain/kinetics[6]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 300.95 8.2163 0 simundump kpool /kinetics/chain/kinetics[6]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 299.92 1.5108 0 simundump kreac 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0 0 0 354 0 0 simundump group /kinetics/chain/kinetics[7]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 350.95 8.2163 0 simundump kpool /kinetics/chain/kinetics[7]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 349.92 1.5108 0 simundump kreac /kinetics/chain/kinetics[7]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 350.92 4.5108 0 simundump kreac /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca 0 7.958e-06 0.5 \ "" white blue 349.92 -0.12295 0 simundump kreac /kinetics/chain/kinetics[7]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 351.94 0.69395 0 simundump kreac /kinetics/chain/kinetics[7]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 350.2 4.2533 0 simundump kreac /kinetics/chain/kinetics[7]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 351.38 2.7362 0 simundump kpool /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb* 0 -1e-12 \ 1.3896e-17 1.3896e-17 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom \ 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10 0 simundump kenz /kinetics/chain/kinetics[7]/PKC-active/PKC-inact-GAP 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 358 13 0 simundump kenz /kinetics/chain/kinetics[7]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 363 20 0 simundump kpool /kinetics/chain/kinetics[7]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 367 1 0 simundump kenz /kinetics/chain/kinetics[7]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange "" 364 10 0 simundump kreac /kinetics/chain/kinetics[7]/MAPK*/diff 0 0.001 0.001 "" white \ black 368 4 0 simundump group /kinetics/chain/kinetics[7]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 369 11 0 simundump kpool /kinetics/chain/kinetics[7]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 360 8 0 simundump kpool /kinetics/chain/kinetics[7]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 363 8 0 simundump kpool 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simundump group /kinetics/chain/kinetics[7]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 344 21 0 simundump kpool /kinetics/chain/kinetics[7]/CaM/CaM 1 -1e-12 20 20 1.5079e+06 \ 1.5079e+06 0 0 75396 0 /kinetics/dendgeom pink blue 341 30 0 simundump kreac /kinetics/chain/kinetics[7]/CaM/CaM/diff 0 0.001 0.001 "" \ white black 342 33 0 simundump kreac /kinetics/chain/kinetics[7]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 343.6 23.26 0 simundump kpool /kinetics/chain/kinetics[7]/CaM/CaM-Ca3 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 347.49 24.397 0 simundump kreac /kinetics/chain/kinetics[7]/CaM/CaM-Ca3/diff 0 0.001 0.001 "" \ white black 348.49 27.397 0 simundump kpool /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom blue blue 352 24 0 simundump kreac /kinetics/chain/kinetics[7]/CaM/CaM-Ca4/diff 0 0.001 0.001 "" \ white black 353 27 0 simundump kreac /kinetics/chain/kinetics[7]/CaM/CaM-bind-Ca 1 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1 "" \ white 25 337 16 0 simundump kpool /kinetics/chain/kinetics[7]/Ca_input 0 0 0.08 0.08 6031.7 \ 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 336 30 0 simundump kreac /kinetics/chain/kinetics[7]/Ca_diff 0 5 5 "" white black 336 \ 26 0 simundump group /kinetics/chain/kinetics[8] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 404 0 0 simundump group /kinetics/chain/kinetics[8]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 400.95 8.2163 0 simundump kpool /kinetics/chain/kinetics[8]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 399.92 1.5108 0 simundump kreac /kinetics/chain/kinetics[8]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 400.92 4.5108 0 simundump kreac /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca 0 7.958e-06 0.5 \ "" white blue 399.92 -0.12295 0 simundump kreac /kinetics/chain/kinetics[8]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 401.94 0.69395 0 simundump kreac 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simundump group /kinetics/chain/kinetics[8]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 419 11 0 simundump kpool /kinetics/chain/kinetics[8]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 410 8 0 simundump kpool /kinetics/chain/kinetics[8]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 413 8 0 simundump kpool /kinetics/chain/kinetics[8]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 410 4 0 simundump kpool /kinetics/chain/kinetics[8]/MAPK/MAPK 0 -1e-12 3.5999 3.5999 \ 2.7142e+05 2.7142e+05 0 0 75396 0 /kinetics/dendgeom pink brown 410 1 0 simundump kreac /kinetics/chain/kinetics[8]/MAPK/MAPK/diff 0 0.001 0.001 "" \ white black 411 4 0 simundump kpool /kinetics/chain/kinetics[8]/MAPK/craf-1** 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink brown 416 8 0 simundump kpool /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr 1 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange brown 413 1 0 simundump kreac /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr/diff 0 0.001 0.001 \ "" white black 414 4 0 simundump kpool /kinetics/chain/kinetics[8]/MAPK/MAPKK* 0 0 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom pink brown 417 4 0 simundump kenz /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 412 3 0 simundump kenz /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 417 3 0 simundump kpool /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 413 4 0 simundump kpool /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 409 6 0 simundump kenz /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 0 \ 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 412 6 0 simundump kenz /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 0 \ 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 415 6 0 simundump kpool /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red brown 409 5 0 simundump kenz /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 412 5 0 simundump kenz /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 415 5 0 simundump kpool /kinetics/chain/kinetics[8]/MKP-1 1 -1e-12 0.02 0.02 1507.9 \ 1507.9 0 0 75396 0 /kinetics/dendgeom hotpink black 409 2 0 simundump kenz /kinetics/chain/kinetics[8]/MKP-1/MKP1-tyr-deph 1 0 0 0 0 \ 75396 3.7895e-05 16 4 0 0 "" red hotpink "" 410 3 0 simundump kenz /kinetics/chain/kinetics[8]/MKP-1/MKP1-thr-deph 1 0 0 0 0 \ 75396 3.7895e-05 16 4 0 0 "" red hotpink "" 415 3 0 simundump kreac /kinetics/chain/kinetics[8]/MKP-1/diff 0 0.001 0.001 "" white \ black 410 5 0 simundump kreac /kinetics/chain/kinetics[8]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 407 9 0 simundump kpool /kinetics/chain/kinetics[8]/PPhosphatase2A 1 -1e-12 1 1 75396 \ 75396 0 0 75396 0 /kinetics/dendgeom hotpink yellow 413 9 0 simundump kenz /kinetics/chain/kinetics[8]/PPhosphatase2A/craf-deph 1 0 0 0 0 \ 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 412 10 0 simundump kenz /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 415 7 0 simundump kenz /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph-ser 1 0 \ 0 0 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 412 7 0 simundump kenz /kinetics/chain/kinetics[8]/PPhosphatase2A/craf**-deph 1 0 0 0 \ 0 0.12566 2.5414e-05 24 6 0 0 "" red hotpink "" 416 10 0 simundump kreac /kinetics/chain/kinetics[8]/PPhosphatase2A/diff 0 0.001 0.001 \ "" white black 414 12 0 simundump group /kinetics/chain/kinetics[8]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 418.51 16.351 0 simundump kreac /kinetics/chain/kinetics[8]/Ras/dephosph-GEF 1 1 0 "" white \ blue 413.07 17.881 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simundump kreac /kinetics/chain/kinetics[11]/Ras/GAP/diff 0 0.001 0.001 "" \ white black 561.65 15.338 0 simundump kreac /kinetics/chain/kinetics[11]/Ras/CaM-bind-GEF 1 0.0026526 1 \ "" white blue 556.49 21.679 0 simundump kpool /kinetics/chain/kinetics[11]/Ras/CaM-GEF 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 559.35 19.58 0 simundump kenz /kinetics/chain/kinetics[11]/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 \ 0 0 75396 2.6261e-05 0.8 0.2 0 0 "" red pink "" 559.02 18.657 0 simundump kreac /kinetics/chain/kinetics[11]/Ras/CaM-GEF/diff 0 0.001 0.001 \ "" white black 560.35 22.58 0 simundump group /kinetics/chain/kinetics[11]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 544 21 0 simundump kpool /kinetics/chain/kinetics[11]/CaM/CaM 1 -1e-12 20 20 \ 1.5079e+06 1.5079e+06 0 0 75396 0 /kinetics/dendgeom pink blue 541 30 0 simundump kreac /kinetics/chain/kinetics[11]/CaM/CaM/diff 0 0.001 0.001 "" \ white black 542 33 0 simundump kreac 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604 0 0 simundump group /kinetics/chain/kinetics[12]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 600.95 8.2163 0 simundump kpool /kinetics/chain/kinetics[12]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 599.92 1.5108 0 simundump kreac /kinetics/chain/kinetics[12]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 600.92 4.5108 0 simundump kreac /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 599.92 -0.12295 0 simundump kreac /kinetics/chain/kinetics[12]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 601.94 0.69395 0 simundump kreac /kinetics/chain/kinetics[12]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 600.2 4.2533 0 simundump kreac /kinetics/chain/kinetics[12]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 601.38 2.7362 0 simundump kpool /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb* 0 -1e-12 \ 1.3896e-17 1.3896e-17 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom 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red yellow "" 610 10 0 simundump kenz /kinetics/chain/kinetics[12]/PKC-active/PKC-inact-GAP 1 0 0 0 \ 0 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 608 13 0 simundump kenz /kinetics/chain/kinetics[12]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 613 20 0 simundump kpool /kinetics/chain/kinetics[12]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 617 1 0 simundump kenz /kinetics/chain/kinetics[12]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange "" 614 10 0 simundump kreac /kinetics/chain/kinetics[12]/MAPK*/diff 0 0.001 0.001 "" \ white black 618 4 0 simundump group /kinetics/chain/kinetics[12]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 619 11 0 simundump kpool /kinetics/chain/kinetics[12]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 610 8 0 simundump kpool /kinetics/chain/kinetics[12]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 613 8 0 simundump kpool /kinetics/chain/kinetics[12]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 610 4 0 simundump kpool /kinetics/chain/kinetics[12]/MAPK/MAPK 0 -1e-12 3.5999 3.5999 \ 2.7142e+05 2.7142e+05 0 0 75396 0 /kinetics/dendgeom pink brown 610 1 0 simundump kreac /kinetics/chain/kinetics[12]/MAPK/MAPK/diff 0 0.001 0.001 "" \ white black 611 4 0 simundump kpool /kinetics/chain/kinetics[12]/MAPK/craf-1** 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink brown 616 8 0 simundump kpool /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr 1 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange brown 613 1 0 simundump kreac /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr/diff 0 0.001 0.001 \ "" white black 614 4 0 simundump kpool /kinetics/chain/kinetics[12]/MAPK/MAPKK* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 617 4 0 simundump kenz /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 612 3 0 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0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 615 7 0 simundump kenz /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph-ser 1 0 \ 0 0 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 612 7 0 simundump kenz /kinetics/chain/kinetics[12]/PPhosphatase2A/craf**-deph 1 0 0 \ 0 0 0.12566 2.5414e-05 24 6 0 0 "" red hotpink "" 616 10 0 simundump kreac /kinetics/chain/kinetics[12]/PPhosphatase2A/diff 0 0.001 \ 0.001 "" white black 614 12 0 simundump group /kinetics/chain/kinetics[12]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 618.51 16.351 0 simundump kreac /kinetics/chain/kinetics[12]/Ras/dephosph-GEF 1 1 0 "" white \ blue 613.07 17.881 0 simundump kpool /kinetics/chain/kinetics[12]/Ras/inact-GEF 1 -1e-12 0.1 0.1 \ 7539.6 7539.6 0 0 75396 0 /kinetics/dendgeom hotpink blue 616.45 18.352 0 simundump kenz /kinetics/chain/kinetics[12]/Ras/inact-GEF/basal_GEF_activity 0 \ 0 0 0 0 75396 1.313e-07 0.08 0.02 0 0 "" red hotpink "" 616 17 0 simundump kreac 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kreac /kinetics/chain/kinetics[12]/Ras/CaM-GEF/diff 0 0.001 0.001 \ "" white black 610.35 22.58 0 simundump group /kinetics/chain/kinetics[12]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 594 21 0 simundump kpool /kinetics/chain/kinetics[12]/CaM/CaM 1 -1e-12 20 20 \ 1.5079e+06 1.5079e+06 0 0 75396 0 /kinetics/dendgeom pink blue 591 30 0 simundump kreac /kinetics/chain/kinetics[12]/CaM/CaM/diff 0 0.001 0.001 "" \ white black 592 33 0 simundump kreac /kinetics/chain/kinetics[12]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 593.6 23.26 0 simundump kpool /kinetics/chain/kinetics[12]/CaM/CaM-Ca3 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 597.49 24.397 0 simundump kreac /kinetics/chain/kinetics[12]/CaM/CaM-Ca3/diff 0 0.001 0.001 \ "" white black 598.49 27.397 0 simundump kpool /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom blue blue 602 24 0 simundump kreac /kinetics/chain/kinetics[12]/CaM/CaM-Ca4/diff 0 0.001 0.001 \ "" white black 603 27 0 simundump kreac /kinetics/chain/kinetics[12]/CaM/CaM-bind-Ca 1 0.00011254 \ 8.4853 "" white blue 594 30 0 simundump kpool /kinetics/chain/kinetics[12]/CaM/CaM-Ca2 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 599 27.258 0 simundump kreac /kinetics/chain/kinetics[12]/CaM/CaM-Ca2/diff 0 0.001 0.001 \ "" white black 600 30.258 0 simundump kreac /kinetics/chain/kinetics[12]/CaM/CaM-Ca2-bind-Ca 1 4.7748e-05 \ 10 "" white blue 595.16 26.225 0 simundump kreac /kinetics/chain/kinetics[12]/CaM/CaM-Ca-bind-Ca 1 0.00011254 \ 8.4853 "" white blue 600 30 0 simundump kpool /kinetics/chain/kinetics[12]/CaM/CaM-Ca 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 597 31 0 simundump kreac /kinetics/chain/kinetics[12]/CaM/CaM-Ca/diff 0 0.001 0.001 "" \ white black 598 34 0 simundump kpool /kinetics/chain/kinetics[12]/Ca 1 -1e-12 0.08 0.08 6031.7 \ 6031.7 0 0 75396 0 /kinetics/dendgeom red black 586 23 0 simundump kreac /kinetics/chain/kinetics[12]/Ca/diff 0 0.001 0.001 "" white \ black 587 26 0 simundump kreac /kinetics/chain/kinetics[12]/Ras-act-unphosph-raf 0 0 0 "" \ white black 608 8 0 simundump group /kinetics/chain/kinetics[12]/PKM 0 25 black x 0 0 "" PKM \ defaultfile.g 0 5dc016e940e88c1cc7928f4e096ff523 0 597 19 0 simundump kpool /kinetics/chain/kinetics[12]/PKM/Ca_detector 0 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom 7 25 593 17 0 simundump kreac /kinetics/chain/kinetics[12]/PKM/Ca_detector/diff 0 0.001 \ 0.001 "" white black 594 20 0 simundump kpool /kinetics/chain/kinetics[12]/PKM/PKM_synthesis 0 -1e-12 0.001 \ 0.001 75.396 75.396 0 0 75396 0 /kinetics/dendgeom 8 25 593 9 0 simundump kenz /kinetics/chain/kinetics[12]/PKM/PKM_synthesis/kenz 0 0 0 0 0 \ 75396 3.3159e-07 0.2 0.05 0 0 "" red 8 "" 594 10 0 simundump kreac /kinetics/chain/kinetics[12]/PKM/PKM_synthesis/diff 0 0.001 \ 0.001 "" white black 594 12 0 simundump kpool /kinetics/chain/kinetics[12]/PKM/AA_pool 0 -1e-12 1 1 75396 \ 75396 0 0 75396 4 /kinetics/dendgeom 9 25 597 12 0 simundump kreac /kinetics/chain/kinetics[12]/PKM/PKM_degradation 0 0.0005 0 \ "" white 25 596 7 0 simundump kpool /kinetics/chain/kinetics[12]/PKM/degraded_PKM 0 -1e-12 0 0 0 \ 0 0 0 75396 4 /kinetics/dendgeom 7 25 592 5 0 simundump kpool /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex 0 -1e-12 \ 0 0 0 0 0 0 75396 0 /kinetics/dendgeom 7 25 592 14 0 simundump kenz /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex/kenz 0 0 \ 0 0 0 75396 2.6526e-06 0.8 0.2 0 0 "" red 7 "" 592 13 0 simundump kreac /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex/diff 0 \ 0.001 0.001 "" white black 593 17 0 simundump kpool /kinetics/chain/kinetics[12]/PKM/PKM_activator 0 -1e-12 0.2 \ 0.2 15079 15079 0 0 75396 0 /kinetics/dendgeom 6 25 589 12 0 simundump kreac /kinetics/chain/kinetics[12]/PKM/PKM_activator/diff 0 0.001 \ 0.001 "" white black 590 15 0 simundump kreac /kinetics/chain/kinetics[12]/PKM/turn_off_activator 0 0.001 0 \ "" white 25 587 9 0 simundump kreac /kinetics/chain/kinetics[12]/PKM/trigger_PKM 0 0.00013263 1 \ "" white 25 587 16 0 simundump kpool /kinetics/chain/kinetics[12]/Ca_input 0 0 0.08 0.08 6031.7 \ 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 586 30 0 simundump kreac /kinetics/chain/kinetics[12]/Ca_diff 0 5 5 "" white black 586 \ 26 0 simundump group /kinetics/chain/kinetics[13] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 654 0 0 simundump group /kinetics/chain/kinetics[13]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 650.95 8.2163 0 simundump kpool /kinetics/chain/kinetics[13]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 649.92 1.5108 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 650.92 4.5108 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 649.92 -0.12295 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 651.94 0.69395 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 650.2 4.2533 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 651.38 2.7362 0 simundump kpool /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb* 0 -1e-12 \ 1.3896e-17 1.3896e-17 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom \ pink blue 651.22 6.529 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb*/diff 0 0.001 \ 0.001 "" white black 652.22 9.529 0 simundump kpool /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb* 0 -1e-12 \ 9.4351e-21 9.4351e-21 7.1137e-16 7.1137e-16 0 0 75396 0 /kinetics/dendgeom \ yellow blue 652.17 5.5078 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb*/diff 0 0.001 \ 0.001 "" white black 653.17 8.5078 0 simundump kpool /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG 0 -1e-12 \ 8.4632e-23 8.4632e-23 6.3809e-18 6.3809e-18 0 0 75396 0 /kinetics/dendgeom \ white blue 654.23 1.8026 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG/diff 0 0.001 \ 0.001 "" white black 655.23 4.8026 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 650.99 -1.9902 0 simundump kpool /kinetics/chain/kinetics[13]/PKC/PKC-DAG 0 -1e-12 1.161e-16 \ 1.161e-16 8.7535e-12 8.7535e-12 0 0 75396 0 /kinetics/dendgeom white blue \ 653 -1.0857 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-DAG/diff 0 0.001 0.001 \ "" white black 654 1.9143 0 simundump kpool /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic 0 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom white blue 647.87 0.59711 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic/diff 0 0.001 \ 0.001 "" white black 648.87 3.5971 0 simundump kpool /kinetics/chain/kinetics[13]/PKC/PKM-zeta 0 -1e-12 0.01 0.01 \ 753.96 753.96 0 0 75396 0 /kinetics/dendgeom cyan blue 651 11 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKM-zeta/diff 0 0.001 0.001 \ "" white black 652 14 0 simundump kpool /kinetics/chain/kinetics[13]/DAG 1 -1e-12 12.2 12.2 \ 9.1983e+05 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 658 -3 0 simundump kpool /kinetics/chain/kinetics[13]/PKC-active 1 -1e-12 0 0.01 \ 753.96 0 0 0 75396 2 /kinetics/dendgeom red black 654 9 0 simundump kenz /kinetics/chain/kinetics[13]/PKC-active/PKC-act-raf 1 0 0 0 0 \ 75396 1.3263e-05 16 4 0 0 "" red yellow "" 660 10 0 simundump kenz /kinetics/chain/kinetics[13]/PKC-active/PKC-inact-GAP 1 0 0 0 \ 0 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 658 13 0 simundump kenz /kinetics/chain/kinetics[13]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 663 20 0 simundump kpool /kinetics/chain/kinetics[13]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 667 1 0 simundump kenz /kinetics/chain/kinetics[13]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange 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16 4 0 0 "" red yellow "" 708 13 0 simundump kenz /kinetics/chain/kinetics[14]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 713 20 0 simundump kpool /kinetics/chain/kinetics[14]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 717 1 0 simundump kenz /kinetics/chain/kinetics[14]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange "" 714 10 0 simundump kreac /kinetics/chain/kinetics[14]/MAPK*/diff 0 0.001 0.001 "" \ white black 718 4 0 simundump group /kinetics/chain/kinetics[14]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 719 11 0 simundump kpool /kinetics/chain/kinetics[14]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 710 8 0 simundump kpool /kinetics/chain/kinetics[14]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 713 8 0 simundump kpool /kinetics/chain/kinetics[14]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom 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white blue 750 30 0 simundump kpool /kinetics/chain/kinetics[15]/CaM/CaM-Ca 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 747 31 0 simundump kreac /kinetics/chain/kinetics[15]/CaM/CaM-Ca/diff 0 0.001 0.001 "" \ white black 748 34 0 simundump kpool /kinetics/chain/kinetics[15]/Ca 1 -1e-12 0.08 0.08 6031.7 \ 6031.7 0 0 75396 0 /kinetics/dendgeom red black 736 23 0 simundump kreac /kinetics/chain/kinetics[15]/Ca/diff 0 0.001 0.001 "" white \ black 737 26 0 simundump kreac /kinetics/chain/kinetics[15]/Ras-act-unphosph-raf 0 0 0 "" \ white black 758 8 0 simundump group /kinetics/chain/kinetics[15]/PKM 0 25 black x 0 0 "" PKM \ defaultfile.g 0 5dc016e940e88c1cc7928f4e096ff523 0 747 19 0 simundump kpool /kinetics/chain/kinetics[15]/PKM/Ca_detector 0 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom 7 25 743 17 0 simundump kreac /kinetics/chain/kinetics[15]/PKM/Ca_detector/diff 0 0.001 \ 0.001 "" white black 744 20 0 simundump kpool 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16 4 0 0 "" red yellow "" 808 13 0 simundump kenz /kinetics/chain/kinetics[16]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 813 20 0 simundump kpool /kinetics/chain/kinetics[16]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 817 1 0 simundump kenz /kinetics/chain/kinetics[16]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange "" 814 10 0 simundump kreac /kinetics/chain/kinetics[16]/MAPK*/diff 0 0.001 0.001 "" \ white black 818 4 0 simundump group /kinetics/chain/kinetics[16]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 819 11 0 simundump kpool /kinetics/chain/kinetics[16]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 810 8 0 simundump kpool /kinetics/chain/kinetics[16]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 813 8 0 simundump kpool /kinetics/chain/kinetics[16]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom 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817 3 0 simundump kpool /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 813 4 0 simundump kpool /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 809 6 0 simundump kenz /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 812 6 0 simundump kenz /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 815 6 0 simundump kpool /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom red brown 809 5 0 simundump kenz /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 812 5 0 simundump kenz /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 815 5 0 simundump kpool /kinetics/chain/kinetics[16]/MKP-1 1 -1e-12 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simundump kpool /kinetics/chain/kinetics[16]/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 810.45 17.246 0 simundump kenz /kinetics/chain/kinetics[16]/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 \ 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 811.09 16.086 0 simundump kreac /kinetics/chain/kinetics[16]/Ras/GEF*/diff 0 0.001 0.001 "" \ white black 811.45 20.246 0 simundump kpool /kinetics/chain/kinetics[16]/Ras/GTP-Ras 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange blue 816.56 13.084 0 simundump kpool /kinetics/chain/kinetics[16]/Ras/GDP-Ras 1 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink blue 810.13 14.165 0 simundump kreac /kinetics/chain/kinetics[16]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 813.1 13.5 0 simundump kreac /kinetics/chain/kinetics[16]/Ras/dephosph-GAP 1 0.1 0 "" \ white blue 808.02 15.524 0 simundump kpool /kinetics/chain/kinetics[16]/Ras/GAP* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red blue 805.35 14.349 0 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0.00013263 1 \ "" white 25 887 16 0 simundump kpool /kinetics/chain/kinetics[18]/Ca_input 0 0 0.08 0.08 6031.7 \ 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 886 30 0 simundump kreac /kinetics/chain/kinetics[18]/Ca_diff 0 5 5 "" white black 886 \ 26 0 simundump group /kinetics/chain/kinetics[19] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 954 0 0 simundump group /kinetics/chain/kinetics[19]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 950.95 8.2163 0 simundump kpool /kinetics/chain/kinetics[19]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 949.92 1.5108 0 simundump kreac /kinetics/chain/kinetics[19]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 950.92 4.5108 0 simundump kreac /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 949.92 -0.12295 0 simundump kreac /kinetics/chain/kinetics[19]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 951.94 0.69395 0 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black 968 4 0 simundump group /kinetics/chain/kinetics[19]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 969 11 0 simundump kpool /kinetics/chain/kinetics[19]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 960 8 0 simundump kpool /kinetics/chain/kinetics[19]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 963 8 0 simundump kpool /kinetics/chain/kinetics[19]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 960 4 0 simundump kpool /kinetics/chain/kinetics[19]/MAPK/MAPK 0 -1e-12 3.5999 3.5999 \ 2.7142e+05 2.7142e+05 0 0 75396 0 /kinetics/dendgeom pink brown 960 1 0 simundump kreac /kinetics/chain/kinetics[19]/MAPK/MAPK/diff 0 0.001 0.001 "" \ white black 961 4 0 simundump kpool /kinetics/chain/kinetics[19]/MAPK/craf-1** 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink brown 966 8 0 simundump kpool /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr 1 -1e-12 0 0 0 0 0 \ 0 75396 0 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kreac /kinetics/chain/kinetics[19]/Ras/CaM-bind-GEF 1 0.0026526 1 \ "" white blue 956.49 21.679 0 simundump kpool /kinetics/chain/kinetics[19]/Ras/CaM-GEF 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 959.35 19.58 0 simundump kenz /kinetics/chain/kinetics[19]/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 \ 0 0 75396 2.6261e-05 0.8 0.2 0 0 "" red pink "" 959.02 18.657 0 simundump kreac /kinetics/chain/kinetics[19]/Ras/CaM-GEF/diff 0 0.001 0.001 \ "" white black 960.35 22.58 0 simundump group /kinetics/chain/kinetics[19]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 944 21 0 simundump kpool /kinetics/chain/kinetics[19]/CaM/CaM 1 -1e-12 20 20 \ 1.5079e+06 1.5079e+06 0 0 75396 0 /kinetics/dendgeom pink blue 941 30 0 simundump kreac /kinetics/chain/kinetics[19]/CaM/CaM/diff 0 0.001 0.001 "" \ white black 942 33 0 simundump kreac /kinetics/chain/kinetics[19]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 943.6 23.26 0 simundump kpool 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white blue 950 30 0 simundump kpool /kinetics/chain/kinetics[19]/CaM/CaM-Ca 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 947 31 0 simundump kreac /kinetics/chain/kinetics[19]/CaM/CaM-Ca/diff 0 0.001 0.001 "" \ white black 948 34 0 simundump kpool /kinetics/chain/kinetics[19]/Ca 1 -1e-12 0.08 0.08 6031.7 \ 6031.7 0 0 75396 0 /kinetics/dendgeom red black 936 23 0 simundump kreac /kinetics/chain/kinetics[19]/Ca/diff 0 0.001 0.001 "" white \ black 937 26 0 simundump kreac /kinetics/chain/kinetics[19]/Ras-act-unphosph-raf 0 0 0 "" \ white black 958 8 0 simundump group /kinetics/chain/kinetics[19]/PKM 0 25 black x 0 0 "" PKM \ defaultfile.g 0 5dc016e940e88c1cc7928f4e096ff523 0 947 19 0 simundump kpool /kinetics/chain/kinetics[19]/PKM/Ca_detector 0 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom 7 25 943 17 0 simundump kreac /kinetics/chain/kinetics[19]/PKM/Ca_detector/diff 0 0.001 \ 0.001 "" white black 944 20 0 simundump kpool 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kreac /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex/diff 0 \ 0.001 0.001 "" white black 943 17 0 simundump kpool /kinetics/chain/kinetics[19]/PKM/PKM_activator 0 -1e-12 0.2 \ 0.2 15079 15079 0 0 75396 0 /kinetics/dendgeom 6 25 939 12 0 simundump kreac /kinetics/chain/kinetics[19]/PKM/PKM_activator/diff 0 0.001 \ 0.001 "" white black 940 15 0 simundump kreac /kinetics/chain/kinetics[19]/PKM/turn_off_activator 0 0.001 0 \ "" white 25 937 9 0 simundump kreac /kinetics/chain/kinetics[19]/PKM/trigger_PKM 0 0.00013263 1 \ "" white 25 937 16 0 simundump kpool /kinetics/chain/kinetics[19]/Ca_input 0 0 0.08 0.08 6031.7 \ 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 936 30 0 simundump kreac /kinetics/chain/kinetics[19]/Ca_diff 0 5 5 "" white black 936 \ 26 0 simundump group /kinetics/chain/kinetics[20] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 1004 0 0 simundump group /kinetics/chain/kinetics[20]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 1001 8.2163 0 simundump kpool /kinetics/chain/kinetics[20]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 999.92 1.5108 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 1000.9 4.5108 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 999.92 -0.12295 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 1001.9 0.69395 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 1000.2 4.2533 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 1001.4 2.7362 0 simundump kpool /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb* 0 -1e-12 \ 1.3896e-17 1.3896e-17 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom \ pink blue 1001.2 6.529 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb*/diff 0 0.001 \ 0.001 "" white black 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7.958e-05 16 4 0 0 "" red yellow "" 1008 13 0 simundump kenz /kinetics/chain/kinetics[20]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 1013 20 0 simundump kpool /kinetics/chain/kinetics[20]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 1017 1 0 simundump kenz /kinetics/chain/kinetics[20]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange "" 1014 10 0 simundump kreac /kinetics/chain/kinetics[20]/MAPK*/diff 0 0.001 0.001 "" \ white black 1018 4 0 simundump group /kinetics/chain/kinetics[20]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 1019 11 0 simundump kpool /kinetics/chain/kinetics[20]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 1010 8 0 simundump kpool /kinetics/chain/kinetics[20]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 1013 8 0 simundump kpool /kinetics/chain/kinetics[20]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 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1.2 0.3 0 0 "" red pink "" 1017 3 0 simundump kpool /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 1013 4 0 simundump kpool /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 1009 6 0 simundump kenz /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 1012 6 0 simundump kenz /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 1015 6 0 simundump kpool /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom red brown 1009 5 0 simundump kenz /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 1012 5 0 simundump kenz /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 1015 5 0 simundump kpool 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21.352 0 simundump kpool /kinetics/chain/kinetics[20]/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 1010.4 17.246 0 simundump kenz /kinetics/chain/kinetics[20]/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 \ 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 1011.1 16.086 0 simundump kreac /kinetics/chain/kinetics[20]/Ras/GEF*/diff 0 0.001 0.001 "" \ white black 1011.4 20.246 0 simundump kpool /kinetics/chain/kinetics[20]/Ras/GTP-Ras 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange blue 1016.6 13.084 0 simundump kpool /kinetics/chain/kinetics[20]/Ras/GDP-Ras 1 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink blue 1010.1 14.165 0 simundump kreac /kinetics/chain/kinetics[20]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 1013.1 13.5 0 simundump kreac /kinetics/chain/kinetics[20]/Ras/dephosph-GAP 1 0.1 0 "" \ white blue 1008 15.524 0 simundump kpool /kinetics/chain/kinetics[20]/Ras/GAP* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red blue 1005.3 14.349 0 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0.00013263 1 \ "" white 25 987 16 0 simundump kpool /kinetics/chain/kinetics[20]/Ca_input 0 0 0.08 0.08 6031.7 \ 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 986 30 0 simundump kreac /kinetics/chain/kinetics[20]/Ca_diff 0 5 5 "" white black 986 \ 26 0 simundump group /kinetics/chain/kinetics[21] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 1054 0 0 simundump group /kinetics/chain/kinetics[21]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 1051 8.2163 0 simundump kpool /kinetics/chain/kinetics[21]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 1049.9 1.5108 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 1050.9 4.5108 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 1049.9 -0.12295 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 1051.9 0.69395 0 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0 1101 8.2163 0 simundump kpool /kinetics/chain/kinetics[22]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 1099.9 1.5108 0 simundump kreac /kinetics/chain/kinetics[22]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 1100.9 4.5108 0 simundump kreac /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 1099.9 -0.12295 0 simundump kreac /kinetics/chain/kinetics[22]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 1101.9 0.69395 0 simundump kreac /kinetics/chain/kinetics[22]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 1100.2 4.2533 0 simundump kreac /kinetics/chain/kinetics[22]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 1101.4 2.7362 0 simundump kpool /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb* 0 -1e-12 \ 1.3896e-17 1.3896e-17 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom \ pink blue 1101.2 6.529 0 simundump kreac /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb*/diff 0 0.001 \ 0.001 "" 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7.958e-05 16 4 0 0 "" red yellow "" 1108 13 0 simundump kenz /kinetics/chain/kinetics[22]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 1113 20 0 simundump kpool /kinetics/chain/kinetics[22]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 1117 1 0 simundump kenz /kinetics/chain/kinetics[22]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange "" 1114 10 0 simundump kreac /kinetics/chain/kinetics[22]/MAPK*/diff 0 0.001 0.001 "" \ white black 1118 4 0 simundump group /kinetics/chain/kinetics[22]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 1119 11 0 simundump kpool /kinetics/chain/kinetics[22]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 1110 8 0 simundump kpool /kinetics/chain/kinetics[22]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 1113 8 0 simundump kpool /kinetics/chain/kinetics[22]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 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1.2 0.3 0 0 "" red pink "" 1117 3 0 simundump kpool /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 1113 4 0 simundump kpool /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 1109 6 0 simundump kenz /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 1112 6 0 simundump kenz /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 1115 6 0 simundump kpool /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom red brown 1109 5 0 simundump kenz /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 1112 5 0 simundump kenz /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 1115 5 0 simundump kpool 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21.352 0 simundump kpool /kinetics/chain/kinetics[22]/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 1110.4 17.246 0 simundump kenz /kinetics/chain/kinetics[22]/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 \ 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 1111.1 16.086 0 simundump kreac /kinetics/chain/kinetics[22]/Ras/GEF*/diff 0 0.001 0.001 "" \ white black 1111.4 20.246 0 simundump kpool /kinetics/chain/kinetics[22]/Ras/GTP-Ras 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange blue 1116.6 13.084 0 simundump kpool /kinetics/chain/kinetics[22]/Ras/GDP-Ras 1 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink blue 1110.1 14.165 0 simundump kreac /kinetics/chain/kinetics[22]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 1113.1 13.5 0 simundump kreac /kinetics/chain/kinetics[22]/Ras/dephosph-GAP 1 0.1 0 "" \ white blue 1108 15.524 0 simundump kpool /kinetics/chain/kinetics[22]/Ras/GAP* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red blue 1105.3 14.349 0 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\ 75396 0 /kinetics/dendgeom pink blue 1147 31 0 simundump kpool /kinetics/chain/kinetics[23]/Ca 1 -1e-12 0.08 0.08 6031.7 \ 6031.7 0 0 75396 0 /kinetics/dendgeom red black 1136 23 0 simundump kreac /kinetics/chain/kinetics[23]/Ras-act-unphosph-raf 0 0 0 "" \ white black 1158 8 0 simundump group /kinetics/chain/kinetics[23]/PKM 0 25 black x 0 0 "" PKM \ defaultfile.g 0 5dc016e940e88c1cc7928f4e096ff523 0 1147 19 0 simundump kpool /kinetics/chain/kinetics[23]/PKM/Ca_detector 0 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom 7 25 1143 17 0 simundump kpool /kinetics/chain/kinetics[23]/PKM/PKM_synthesis 0 -1e-12 0.001 \ 0.001 75.396 75.396 0 0 75396 0 /kinetics/dendgeom 8 25 1143 9 0 simundump kenz /kinetics/chain/kinetics[23]/PKM/PKM_synthesis/kenz 0 0 0 0 0 \ 75396 3.3159e-07 0.2 0.05 0 0 "" red 8 "" 1144 10 0 simundump kpool /kinetics/chain/kinetics[23]/PKM/AA_pool 0 -1e-12 1 1 75396 \ 75396 0 0 75396 4 /kinetics/dendgeom 9 25 1147 12 0 simundump kreac /kinetics/chain/kinetics[23]/PKM/PKM_degradation 0 0.0005 0 \ "" white 25 1146 7 0 simundump kpool /kinetics/chain/kinetics[23]/PKM/degraded_PKM 0 -1e-12 0 0 0 \ 0 0 0 75396 4 /kinetics/dendgeom 7 25 1142 5 0 simundump kpool /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex 0 -1e-12 \ 0 0 0 0 0 0 75396 0 /kinetics/dendgeom 7 25 1142 14 0 simundump kenz /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex/kenz 0 0 \ 0 0 0 75396 2.6526e-06 0.8 0.2 0 0 "" red 7 "" 1142 13 0 simundump kpool /kinetics/chain/kinetics[23]/PKM/PKM_activator 0 -1e-12 0.2 \ 0.2 15079 15079 0 0 75396 0 /kinetics/dendgeom 6 25 1139 12 0 simundump kreac /kinetics/chain/kinetics[23]/PKM/turn_off_activator 0 0.001 0 \ "" white 25 1137 9 0 simundump kreac /kinetics/chain/kinetics[23]/PKM/trigger_PKM 0 0.00013263 1 \ "" white 25 1137 16 0 simundump kpool /kinetics/chain/kinetics[23]/Ca_input 0 0 0.08 0.08 6031.7 \ 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 1136 30 0 simundump kreac /kinetics/chain/kinetics[23]/Ca_diff 0 5 5 "" white black \ 1136 26 0 simundump doqcsinfo /kinetics/doqcsinfo 0 Ajay_Bhalla_2007_ReacDiff1_1e-13.g \ Ajay_Bhalla_2007_ReacDiff1_1e-13 network "Upinder S. Bhalla, NCBS" \ "Upinder S. Bhalla, NCBS" "citation here" Rat "Hippocampal CA1" Dendrite \ "Semi-Quantitative match to experiments" \ "Ajay_Bhalla_rec_diff1 (Under Review)" "Exact GENESIS implementation" \ "Replicates original data " 0 0 0 simundump xgraph /graphs/conc1 0 0 4001 0.00087037 0.10434 0 simundump xgraph /graphs/conc2 0 0 4001 0 0.088747 0 simundump xgraph /moregraphs/conc3 0 0 4001 0 1 0 simundump xgraph /moregraphs/conc4 0 0 4001 0 1 0 simundump xcoredraw /edit/draw 0 -20 1171 -5 36 simundump xtree /edit/draw/tree 0 \ /kinetics/#[],/kinetics/#[]/#[],/kinetics/#[]/#[]/#[][TYPE!=proto],/kinetics/#[]/#[]/#[][TYPE!=linkinfo]/##[] \ "edit_elm.D ; drag_from_edit.w " auto 0.6 simundump xtext /file/notes 0 1 xtextload /file/notes \ "27 Feb 2006. Updated version of pkm_mapk1.g Set up diffusion constants," \ "or more accurately, decided which molecules should not diffuse." \ "2 March 2006. Based on pkm_mapk2.g, just added Ca_input and" \ "Ca_diff to set up the propagation model with slightly smoother" \ "Ca transients. This matches the PKC-MAPK bis model." \ "Saved as pkm_mapk3.g" \ "13 Mar 2006. Speeded up rates of trigger_PKM 10x from the " \ "pkm_mapk3.g model. Also speeded up Ca_diff rates from tau of 0.25" \ "to tau of 0.1" \ "Saved as pkm_mapk12.g" \ "13 Mar 2006. Same as previous, except the trigger_PKM Kd is" \ "now 1.4142. Saved as" \ "pkm_mapk13.g" \ "17 Marh 2006. Changed Ca trigger for PKM Synthesis to depend on" \ "Ca4.CaM. Also scaled up CaM-GEF-act-ras kcat from 0.02 to 0.4." \ "Saved as pkm_mapk20.g" \ "17 March. Based on pkm_mapk20.g Changed CaM-GEF-act-ras kcat " \ "to 0.2." \ "Saved as pkm_mapk21.g" \ "" \ "19 May 2006. Based on pkm_mapk21.g. Split up initial step of" \ "2Ca binding to CaM into two reactions, in each of which 1 Ca" \ "binds. Improves numerical stability but overall equil should" \ "not change. " \ "Saved as pkm_mapk22.g" \ "16 Sep 2006. Made diffusion model with D = 1e-13 m^2/sec" \ "" addmsg /kinetics/PKC/PKC-act-by-Ca /kinetics/PKC/PKC-Ca REAC B A addmsg /kinetics/PKC/PKC-act-by-DAG /kinetics/PKC/PKC-Ca REAC A B addmsg /kinetics/PKC/PKC-Ca-to-memb /kinetics/PKC/PKC-Ca REAC A B addmsg /kinetics/PKC/PKC-Ca/diff /kinetics/PKC/PKC-Ca REAC A B addmsg /kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/PKC/PKC-cytosolic /kinetics/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/Ca /kinetics/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/DAG /kinetics/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/PKC/PKC-Ca-DAG /kinetics/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/PKC/PKC-Ca-memb* /kinetics/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/PKC/PKC-Ca-DAG /kinetics/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/PKC/PKC-DAG-memb* /kinetics/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/PKC/PKC-Ca-to-memb /kinetics/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/PKC/PKC-Ca-memb*/diff /kinetics/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/PKC/PKC-Ca-memb* /kinetics/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-memb* /kinetics/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/PKC/PKC-DAG-to-memb /kinetics/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/PKC/PKC-DAG-memb*/diff /kinetics/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/PKC/PKC-DAG-memb* /kinetics/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-memb* /kinetics/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/PKC/PKC-act-by-DAG /kinetics/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/PKC/PKC-DAG-to-memb /kinetics/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/PKC/PKC-Ca-DAG/diff /kinetics/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/PKC/PKC-Ca-DAG /kinetics/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-DAG /kinetics/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/PKC/PKC-cytosolic /kinetics/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/DAG /kinetics/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/PKC/PKC-DAG /kinetics/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/PKC/PKC-n-DAG /kinetics/PKC/PKC-DAG REAC B A addmsg /kinetics/PKC/PKC-DAG/diff /kinetics/PKC/PKC-DAG REAC A B addmsg /kinetics/PKC/PKC-DAG /kinetics/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-DAG /kinetics/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/PKC/PKC-act-by-Ca /kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/PKC/PKC-n-DAG /kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/PKC/PKC-cytosolic/diff /kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/PKC/PKC-cytosolic /kinetics/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-cytosolic /kinetics/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/PKM/PKM_synthesis/kenz /kinetics/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/PKM/PKM_degradation /kinetics/PKC/PKM-zeta REAC A B addmsg /kinetics/PKC/PKM-zeta/diff /kinetics/PKC/PKM-zeta REAC A B addmsg /kinetics/PKC/PKM-zeta /kinetics/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKM-zeta /kinetics/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/PKC/PKC-act-by-DAG /kinetics/DAG REAC A B addmsg /kinetics/PKC/PKC-n-DAG /kinetics/DAG REAC A B addmsg /kinetics/PKC/PKC-Ca-memb* /kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/PKC/PKC-DAG-memb* /kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/PKC-active/PKC-act-raf /kinetics/PKC-active REAC eA B addmsg /kinetics/PKC-active/PKC-inact-GAP /kinetics/PKC-active REAC eA B addmsg /kinetics/PKC-active/PKC-act-GEF /kinetics/PKC-active REAC eA B addmsg /kinetics/PKC/PKM-zeta /kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/PKC-active /kinetics/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/MAPK/craf-1 /kinetics/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/PKC-active /kinetics/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/Ras/GAP /kinetics/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/PKC-active /kinetics/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/Ras/inact-GEF /kinetics/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/MAPK*/MAPK*-feedback /kinetics/MAPK* REAC eA B addmsg /kinetics/MAPK/MAPKK*/MAPKKthr /kinetics/MAPK* MM_PRD pA addmsg /kinetics/MKP-1/MKP1-thr-deph /kinetics/MAPK* REAC sA B addmsg /kinetics/MAPK*/diff /kinetics/MAPK* REAC A B addmsg /kinetics/MAPK* /kinetics/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/MAPK/craf-1* /kinetics/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/MAPK* /kinetics/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK* /kinetics/MAPK*/diff PRODUCT n addmsg /kinetics/PKC-active/PKC-act-raf /kinetics/MAPK/craf-1 REAC sA B addmsg /kinetics/PPhosphatase2A/craf-deph /kinetics/MAPK/craf-1 MM_PRD pA addmsg /kinetics/Ras-act-unphosph-raf /kinetics/MAPK/craf-1 REAC A B addmsg /kinetics/PKC-active/PKC-act-raf /kinetics/MAPK/craf-1* MM_PRD pA addmsg /kinetics/MAPK*/MAPK*-feedback /kinetics/MAPK/craf-1* REAC sA B addmsg /kinetics/PPhosphatase2A/craf-deph /kinetics/MAPK/craf-1* REAC sA B addmsg /kinetics/PPhosphatase2A/craf**-deph /kinetics/MAPK/craf-1* MM_PRD pA addmsg /kinetics/Ras-act-craf /kinetics/MAPK/craf-1* REAC A B addmsg /kinetics/PPhosphatase2A/MAPKK-deph-ser /kinetics/MAPK/MAPKK MM_PRD pA addmsg /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/MAPK/MAPKK REAC sA B addmsg /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/MAPK/MAPKK REAC sA B addmsg /kinetics/MAPK/MAPKK*/MAPKKtyr /kinetics/MAPK/MAPK REAC sA B addmsg /kinetics/MKP-1/MKP1-tyr-deph /kinetics/MAPK/MAPK MM_PRD pA addmsg /kinetics/MAPK/MAPK/diff /kinetics/MAPK/MAPK REAC A B addmsg /kinetics/MAPK/MAPK /kinetics/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/MAPK /kinetics/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/MAPK*/MAPK*-feedback /kinetics/MAPK/craf-1** MM_PRD pA addmsg /kinetics/PPhosphatase2A/craf**-deph /kinetics/MAPK/craf-1** REAC sA B addmsg /kinetics/MAPK/MAPKK*/MAPKKtyr /kinetics/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/MAPK/MAPKK*/MAPKKthr /kinetics/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/MKP-1/MKP1-tyr-deph /kinetics/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/MKP-1/MKP1-thr-deph /kinetics/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/MAPK/MAPK-tyr/diff /kinetics/MAPK/MAPK-tyr REAC A B addmsg /kinetics/MAPK/MAPK-tyr /kinetics/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/MAPK-tyr /kinetics/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/MAPK/MAPKK*/MAPKKtyr /kinetics/MAPK/MAPKK* REAC eA B addmsg /kinetics/MAPK/MAPKK*/MAPKKthr /kinetics/MAPK/MAPKK* REAC eA B addmsg /kinetics/PPhosphatase2A/MAPKK-deph /kinetics/MAPK/MAPKK* REAC sA B addmsg /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/MAPK/MAPKK* /kinetics/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/MAPK/MAPK /kinetics/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/MAPK/MAPKK* /kinetics/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/MAPK/MAPK-tyr /kinetics/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/PPhosphatase2A/MAPKK-deph /kinetics/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/PPhosphatase2A/MAPKK-deph-ser /kinetics/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/Ras-act-unphosph-raf /kinetics/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/MAPK/Raf-GTP-Ras /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/MAPK/MAPKK /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/MAPK/Raf-GTP-Ras /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/MAPK/MAPKK-ser /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/Ras-act-craf /kinetics/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/MAPK/Raf*-GTP-Ras /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/MAPK/MAPKK /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/MAPK/Raf*-GTP-Ras /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/MAPK/MAPKK-ser /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/MKP-1/MKP1-tyr-deph /kinetics/MKP-1 REAC eA B addmsg /kinetics/MKP-1/MKP1-thr-deph /kinetics/MKP-1 REAC eA B addmsg /kinetics/MKP-1/diff /kinetics/MKP-1 REAC A B addmsg /kinetics/MKP-1 /kinetics/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/MAPK/MAPK-tyr /kinetics/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/MKP-1 /kinetics/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/MAPK* /kinetics/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/MKP-1 /kinetics/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/MKP-1 /kinetics/MKP-1/diff PRODUCT n addmsg /kinetics/MAPK/craf-1* /kinetics/Ras-act-craf SUBSTRATE n addmsg /kinetics/Ras/GTP-Ras /kinetics/Ras-act-craf SUBSTRATE n addmsg /kinetics/MAPK/Raf*-GTP-Ras /kinetics/Ras-act-craf PRODUCT n addmsg /kinetics/PPhosphatase2A/craf-deph /kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/PPhosphatase2A/MAPKK-deph /kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/PPhosphatase2A/MAPKK-deph-ser /kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/PPhosphatase2A/craf**-deph /kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/PPhosphatase2A/diff /kinetics/PPhosphatase2A REAC A B addmsg /kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/MAPK/craf-1* /kinetics/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/MAPK/MAPKK* /kinetics/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/MAPK/MAPKK-ser /kinetics/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/MAPK/craf-1** /kinetics/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/Ras/GEF* /kinetics/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/Ras/inact-GEF /kinetics/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/PKC-active/PKC-act-GEF /kinetics/Ras/inact-GEF REAC sA B addmsg /kinetics/Ras/dephosph-GEF /kinetics/Ras/inact-GEF REAC B A addmsg /kinetics/Ras/CaM-bind-GEF /kinetics/Ras/inact-GEF REAC A B addmsg /kinetics/Ras/inact-GEF/basal_GEF_activity /kinetics/Ras/inact-GEF REAC eA B addmsg /kinetics/Ras/inact-GEF/diff /kinetics/Ras/inact-GEF REAC A B addmsg /kinetics/Ras/inact-GEF /kinetics/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/Ras/GDP-Ras /kinetics/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/Ras/inact-GEF /kinetics/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/inact-GEF /kinetics/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/PKC-active/PKC-act-GEF /kinetics/Ras/GEF* MM_PRD pA addmsg /kinetics/Ras/dephosph-GEF /kinetics/Ras/GEF* REAC A B addmsg /kinetics/Ras/GEF*/GEF*-act-ras /kinetics/Ras/GEF* REAC eA B addmsg /kinetics/Ras/GEF*/diff /kinetics/Ras/GEF* REAC A B addmsg /kinetics/Ras/GEF* /kinetics/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/Ras/GDP-Ras /kinetics/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/Ras/GEF* /kinetics/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/GEF* /kinetics/Ras/GEF*/diff PRODUCT n addmsg /kinetics/Ras/GAP/GAP-inact-ras /kinetics/Ras/GTP-Ras REAC sA B addmsg /kinetics/Ras/Ras-intrinsic-GTPase /kinetics/Ras/GTP-Ras REAC A B addmsg /kinetics/Ras/GEF*/GEF*-act-ras /kinetics/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/Ras-act-craf /kinetics/Ras/GTP-Ras REAC A B addmsg /kinetics/Ras-act-unphosph-raf /kinetics/Ras/GTP-Ras REAC A B addmsg /kinetics/Ras/inact-GEF/basal_GEF_activity /kinetics/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/Ras/GAP/GAP-inact-ras /kinetics/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/Ras/Ras-intrinsic-GTPase /kinetics/Ras/GDP-Ras REAC B A addmsg /kinetics/Ras/GEF*/GEF*-act-ras /kinetics/Ras/GDP-Ras REAC sA B addmsg /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/Ras/GDP-Ras REAC sA B addmsg /kinetics/Ras/inact-GEF/basal_GEF_activity /kinetics/Ras/GDP-Ras REAC sA B addmsg /kinetics/Ras/GTP-Ras /kinetics/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/Ras/GDP-Ras /kinetics/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/Ras/GAP* /kinetics/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/Ras/GAP /kinetics/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/PKC-active/PKC-inact-GAP /kinetics/Ras/GAP* MM_PRD pA addmsg /kinetics/Ras/dephosph-GAP /kinetics/Ras/GAP* REAC A B addmsg /kinetics/Ras/GAP*/diff /kinetics/Ras/GAP* REAC A B addmsg /kinetics/Ras/GAP* /kinetics/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/GAP* /kinetics/Ras/GAP*/diff PRODUCT n addmsg /kinetics/Ras/GAP/GAP-inact-ras /kinetics/Ras/GAP REAC eA B addmsg /kinetics/PKC-active/PKC-inact-GAP /kinetics/Ras/GAP REAC sA B addmsg /kinetics/Ras/dephosph-GAP /kinetics/Ras/GAP REAC B A addmsg /kinetics/Ras/GAP/diff /kinetics/Ras/GAP REAC A B addmsg /kinetics/Ras/GAP /kinetics/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/Ras/GTP-Ras /kinetics/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/Ras/GAP /kinetics/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/GAP /kinetics/Ras/GAP/diff PRODUCT n addmsg /kinetics/Ras/inact-GEF /kinetics/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/Ras/CaM-GEF /kinetics/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/CaM/CaM-Ca4 /kinetics/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/Ras/CaM-bind-GEF /kinetics/Ras/CaM-GEF REAC B A addmsg /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/Ras/CaM-GEF REAC eA B addmsg /kinetics/Ras/CaM-GEF/diff /kinetics/Ras/CaM-GEF REAC A B addmsg /kinetics/Ras/CaM-GEF /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/Ras/GDP-Ras /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/Ras/CaM-GEF /kinetics/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/CaM-GEF /kinetics/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/CaM/CaM-bind-Ca /kinetics/CaM/CaM REAC A B addmsg /kinetics/CaM/CaM/diff /kinetics/CaM/CaM REAC A B addmsg /kinetics/CaM/CaM /kinetics/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM /kinetics/CaM/CaM/diff PRODUCT n addmsg /kinetics/CaM/CaM-Ca3 /kinetics/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/Ca /kinetics/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/CaM/CaM-Ca4 /kinetics/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/CaM/CaM-Ca2-bind-Ca /kinetics/CaM/CaM-Ca3 REAC B A addmsg /kinetics/CaM/CaM-Ca3-bind-Ca /kinetics/CaM/CaM-Ca3 REAC A B addmsg /kinetics/CaM/CaM-Ca3/diff /kinetics/CaM/CaM-Ca3 REAC A B addmsg /kinetics/CaM/CaM-Ca3 /kinetics/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca3 /kinetics/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/Ras/CaM-bind-GEF /kinetics/CaM/CaM-Ca4 REAC A B addmsg /kinetics/CaM/CaM-Ca3-bind-Ca /kinetics/CaM/CaM-Ca4 REAC B A addmsg /kinetics/PKM/trigger_PKM /kinetics/CaM/CaM-Ca4 REAC A B addmsg /kinetics/CaM/CaM-Ca4/diff /kinetics/CaM/CaM-Ca4 REAC A B addmsg /kinetics/CaM/CaM-Ca4 /kinetics/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca4 /kinetics/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/CaM/CaM /kinetics/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/Ca /kinetics/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/CaM/CaM-Ca /kinetics/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/CaM/CaM-Ca2-bind-Ca /kinetics/CaM/CaM-Ca2 REAC A B addmsg /kinetics/CaM/CaM-Ca-bind-Ca /kinetics/CaM/CaM-Ca2 REAC B A addmsg /kinetics/CaM/CaM-Ca2/diff /kinetics/CaM/CaM-Ca2 REAC A B addmsg /kinetics/CaM/CaM-Ca2 /kinetics/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca2 /kinetics/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/CaM/CaM-Ca2 /kinetics/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/Ca /kinetics/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/CaM/CaM-Ca3 /kinetics/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/CaM/CaM-Ca /kinetics/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/Ca /kinetics/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/CaM/CaM-Ca2 /kinetics/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/CaM/CaM-bind-Ca /kinetics/CaM/CaM-Ca REAC B A addmsg /kinetics/CaM/CaM-Ca-bind-Ca /kinetics/CaM/CaM-Ca REAC A B addmsg /kinetics/CaM/CaM-Ca/diff /kinetics/CaM/CaM-Ca REAC A B addmsg /kinetics/CaM/CaM-Ca /kinetics/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca /kinetics/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/PKC/PKC-act-by-Ca /kinetics/Ca REAC A B addmsg /kinetics/CaM/CaM-bind-Ca /kinetics/Ca REAC A B addmsg /kinetics/CaM/CaM-Ca2-bind-Ca /kinetics/Ca REAC A B addmsg /kinetics/CaM/CaM-Ca3-bind-Ca /kinetics/Ca REAC A B addmsg /kinetics/Ca_diff /kinetics/Ca REAC B A addmsg /kinetics/CaM/CaM-Ca-bind-Ca /kinetics/Ca REAC A B addmsg /kinetics/Ca/diff /kinetics/Ca REAC A B addmsg /kinetics/Ca /kinetics/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/Ca /kinetics/Ca/diff PRODUCT n addmsg /kinetics/MAPK/craf-1 /kinetics/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/MAPK/Raf-GTP-Ras /kinetics/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/Ras/GTP-Ras /kinetics/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/PKM/trigger_PKM /kinetics/PKM/Ca_detector REAC A B addmsg /kinetics/PKM/Ca_detector/diff /kinetics/PKM/Ca_detector REAC A B addmsg /kinetics/PKM/Ca_detector /kinetics/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKM/Ca_detector /kinetics/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/PKM/PKM_synthesis/kenz /kinetics/PKM/PKM_synthesis REAC eA B addmsg /kinetics/PKM/Ca.detector_complex/kenz /kinetics/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/PKM/turn_off_activator /kinetics/PKM/PKM_synthesis REAC A B addmsg /kinetics/PKM/PKM_synthesis/diff /kinetics/PKM/PKM_synthesis REAC A B addmsg /kinetics/PKM/PKM_synthesis /kinetics/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/PKM/AA_pool /kinetics/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/PKM/PKM_synthesis /kinetics/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKM/PKM_synthesis /kinetics/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/PKM/PKM_synthesis/kenz /kinetics/PKM/AA_pool REAC sA B addmsg /kinetics/PKC/PKM-zeta /kinetics/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/PKM/degraded_PKM /kinetics/PKM/PKM_degradation PRODUCT n addmsg /kinetics/PKM/PKM_degradation /kinetics/PKM/degraded_PKM REAC B A addmsg /kinetics/PKM/Ca.detector_complex/kenz /kinetics/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/PKM/trigger_PKM /kinetics/PKM/Ca.detector_complex REAC B A addmsg /kinetics/PKM/Ca.detector_complex/diff /kinetics/PKM/Ca.detector_complex REAC A B addmsg /kinetics/PKM/Ca.detector_complex /kinetics/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/PKM/PKM_activator /kinetics/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/PKM/Ca.detector_complex /kinetics/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKM/Ca.detector_complex /kinetics/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/PKM/Ca.detector_complex/kenz /kinetics/PKM/PKM_activator REAC sA B addmsg /kinetics/PKM/turn_off_activator /kinetics/PKM/PKM_activator REAC B A addmsg /kinetics/PKM/PKM_activator/diff /kinetics/PKM/PKM_activator REAC A B addmsg /kinetics/PKM/PKM_activator /kinetics/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKM/PKM_activator /kinetics/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/PKM/PKM_synthesis /kinetics/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/PKM/PKM_activator /kinetics/PKM/turn_off_activator PRODUCT n addmsg /kinetics/PKM/Ca_detector /kinetics/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/PKM/Ca.detector_complex /kinetics/PKM/trigger_PKM PRODUCT n addmsg /kinetics/CaM/CaM-Ca4 /kinetics/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/Ca_diff /kinetics/Ca_input REAC A B addmsg /kinetics/Ca_input /kinetics/Ca_diff SUBSTRATE n addmsg /kinetics/Ca /kinetics/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-act-by-Ca /kinetics/chain/kinetics/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-act-by-DAG /kinetics/chain/kinetics/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-Ca/diff /kinetics/chain/kinetics/PKC/PKC-Ca REAC A B addmsg /kinetics/PKC/PKC-Ca/diff /kinetics/chain/kinetics/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-Ca /kinetics/chain/kinetics/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca /kinetics/chain/kinetics/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca /kinetics/chain/kinetics/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-cytosolic /kinetics/chain/kinetics/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics/Ca /kinetics/chain/kinetics/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca /kinetics/chain/kinetics/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-DAG /kinetics/chain/kinetics/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics/DAG /kinetics/chain/kinetics/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca /kinetics/chain/kinetics/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-memb* /kinetics/chain/kinetics/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-memb* /kinetics/chain/kinetics/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-DAG /kinetics/chain/kinetics/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-memb* /kinetics/chain/kinetics/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-memb* /kinetics/chain/kinetics/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-act-by-DAG /kinetics/chain/kinetics/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-DAG /kinetics/chain/kinetics/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-DAG /kinetics/chain/kinetics/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-cytosolic /kinetics/chain/kinetics/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics/DAG /kinetics/chain/kinetics/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-n-DAG /kinetics/chain/kinetics/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-DAG/diff /kinetics/chain/kinetics/PKC/PKC-DAG REAC A B addmsg /kinetics/PKC/PKC-DAG/diff /kinetics/chain/kinetics/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-DAG /kinetics/chain/kinetics/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG /kinetics/chain/kinetics/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-act-by-Ca /kinetics/chain/kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-n-DAG /kinetics/chain/kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-cytosolic /kinetics/chain/kinetics/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic /kinetics/chain/kinetics/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics/PKM/PKM_degradation /kinetics/chain/kinetics/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics/PKC/PKM-zeta/diff /kinetics/chain/kinetics/PKC/PKM-zeta REAC A B addmsg /kinetics/PKC/PKM-zeta/diff /kinetics/chain/kinetics/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics/PKC/PKM-zeta /kinetics/chain/kinetics/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKM-zeta /kinetics/chain/kinetics/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-act-by-DAG /kinetics/chain/kinetics/DAG REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-n-DAG /kinetics/chain/kinetics/DAG REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-memb* /kinetics/chain/kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-memb* /kinetics/chain/kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics/PKC/PKM-zeta /kinetics/chain/kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics/PKC-active/PKC-act-raf /kinetics/chain/kinetics/PKC-active REAC eA B addmsg /kinetics/chain/kinetics/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics/PKC-active REAC eA B addmsg /kinetics/chain/kinetics/PKC-active/PKC-act-GEF /kinetics/chain/kinetics/PKC-active REAC eA B addmsg /kinetics/chain/kinetics/PKC-active /kinetics/chain/kinetics/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics/MAPK/craf-1 /kinetics/chain/kinetics/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC-active /kinetics/chain/kinetics/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics/Ras/GAP /kinetics/chain/kinetics/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC-active /kinetics/chain/kinetics/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics/Ras/inact-GEF /kinetics/chain/kinetics/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK*/MAPK*-feedback /kinetics/chain/kinetics/MAPK* REAC eA B addmsg /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics/MAPK* REAC sA B addmsg /kinetics/chain/kinetics/MAPK*/diff /kinetics/chain/kinetics/MAPK* REAC A B addmsg /kinetics/MAPK*/diff /kinetics/chain/kinetics/MAPK* REAC B A addmsg /kinetics/chain/kinetics/MAPK* /kinetics/chain/kinetics/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics/MAPK/craf-1* /kinetics/chain/kinetics/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK* /kinetics/chain/kinetics/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK* /kinetics/chain/kinetics/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC-active/PKC-act-raf /kinetics/chain/kinetics/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics/PPhosphatase2A/craf-deph /kinetics/chain/kinetics/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics/Ras-act-unphosph-raf /kinetics/chain/kinetics/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics/PKC-active/PKC-act-raf /kinetics/chain/kinetics/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK*/MAPK*-feedback /kinetics/chain/kinetics/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics/Ras-act-craf /kinetics/chain/kinetics/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics/PPhosphatase2A/craf-deph /kinetics/chain/kinetics/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/MAPK/diff /kinetics/chain/kinetics/MAPK/MAPK REAC A B addmsg /kinetics/MAPK/MAPK/diff /kinetics/chain/kinetics/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics/MAPK/MAPK /kinetics/chain/kinetics/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK /kinetics/chain/kinetics/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics/MAPK*/MAPK*-feedback /kinetics/chain/kinetics/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics/MAPK/MAPK-tyr REAC A B addmsg /kinetics/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics/MAPK/MAPK-tyr /kinetics/chain/kinetics/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr /kinetics/chain/kinetics/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics/MAPK/MAPK /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/MAPKK* /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics/MAPK/MAPK-tyr /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/MAPKK* /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics/Ras-act-unphosph-raf /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics/MAPK/MAPKK /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics/MAPK/MAPKK-ser /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics/Ras-act-craf /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics/MAPK/MAPKK /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics/MAPK/MAPKK-ser /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics/MKP-1/diff /kinetics/chain/kinetics/MKP-1 REAC A B addmsg /kinetics/MKP-1/diff /kinetics/chain/kinetics/MKP-1 REAC B A addmsg /kinetics/chain/kinetics/MAPK/MAPK-tyr /kinetics/chain/kinetics/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics/MKP-1 /kinetics/chain/kinetics/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics/MAPK* /kinetics/chain/kinetics/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics/MKP-1 /kinetics/chain/kinetics/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics/MKP-1 /kinetics/chain/kinetics/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MKP-1 /kinetics/chain/kinetics/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics/MAPK/craf-1* /kinetics/chain/kinetics/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics/Ras/GTP-Ras /kinetics/chain/kinetics/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics/PPhosphatase2A/craf-deph /kinetics/chain/kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics/PPhosphatase2A/diff /kinetics/chain/kinetics/PPhosphatase2A REAC A B addmsg /kinetics/PPhosphatase2A/diff /kinetics/chain/kinetics/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics/MAPK/craf-1* /kinetics/chain/kinetics/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics/PPhosphatase2A /kinetics/chain/kinetics/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics/MAPK/MAPKK* /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics/PPhosphatase2A /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics/MAPK/MAPKK-ser /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics/PPhosphatase2A /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics/MAPK/craf-1** /kinetics/chain/kinetics/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics/PPhosphatase2A /kinetics/chain/kinetics/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics/PPhosphatase2A /kinetics/chain/kinetics/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A /kinetics/chain/kinetics/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics/Ras/inact-GEF /kinetics/chain/kinetics/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics/Ras/GEF* /kinetics/chain/kinetics/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC-active/PKC-act-GEF /kinetics/chain/kinetics/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics/Ras/dephosph-GEF /kinetics/chain/kinetics/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics/Ras/CaM-bind-GEF /kinetics/chain/kinetics/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics/Ras/inact-GEF/diff /kinetics/chain/kinetics/Ras/inact-GEF REAC A B addmsg /kinetics/Ras/inact-GEF/diff /kinetics/chain/kinetics/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics/Ras/inact-GEF /kinetics/chain/kinetics/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics/Ras/GDP-Ras /kinetics/chain/kinetics/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/inact-GEF /kinetics/chain/kinetics/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF /kinetics/chain/kinetics/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC-active/PKC-act-GEF /kinetics/chain/kinetics/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics/Ras/dephosph-GEF /kinetics/chain/kinetics/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics/Ras/GEF*/diff /kinetics/chain/kinetics/Ras/GEF* REAC A B addmsg /kinetics/Ras/GEF*/diff /kinetics/chain/kinetics/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics/Ras/GEF* /kinetics/chain/kinetics/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics/Ras/GDP-Ras /kinetics/chain/kinetics/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/GEF* /kinetics/chain/kinetics/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/GEF* /kinetics/chain/kinetics/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics/Ras-act-craf /kinetics/chain/kinetics/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics/Ras-act-unphosph-raf /kinetics/chain/kinetics/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics/Ras/GTP-Ras /kinetics/chain/kinetics/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/GDP-Ras /kinetics/chain/kinetics/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics/Ras/GAP* /kinetics/chain/kinetics/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/GAP /kinetics/chain/kinetics/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics/Ras/dephosph-GAP /kinetics/chain/kinetics/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics/Ras/GAP*/diff /kinetics/chain/kinetics/Ras/GAP* REAC A B addmsg /kinetics/Ras/GAP*/diff /kinetics/chain/kinetics/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics/Ras/GAP* /kinetics/chain/kinetics/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/GAP* /kinetics/chain/kinetics/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics/Ras/dephosph-GAP /kinetics/chain/kinetics/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics/Ras/GAP/diff /kinetics/chain/kinetics/Ras/GAP REAC A B addmsg /kinetics/Ras/GAP/diff /kinetics/chain/kinetics/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics/Ras/GTP-Ras /kinetics/chain/kinetics/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/GAP /kinetics/chain/kinetics/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics/Ras/GAP /kinetics/chain/kinetics/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/GAP /kinetics/chain/kinetics/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics/Ras/inact-GEF /kinetics/chain/kinetics/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/CaM-GEF /kinetics/chain/kinetics/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca4 /kinetics/chain/kinetics/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/CaM-bind-GEF /kinetics/chain/kinetics/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics/Ras/CaM-GEF/diff /kinetics/chain/kinetics/Ras/CaM-GEF REAC A B addmsg /kinetics/Ras/CaM-GEF/diff /kinetics/chain/kinetics/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics/Ras/GDP-Ras /kinetics/chain/kinetics/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/CaM-GEF /kinetics/chain/kinetics/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics/Ras/CaM-GEF /kinetics/chain/kinetics/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/CaM-GEF /kinetics/chain/kinetics/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics/CaM/CaM-bind-Ca /kinetics/chain/kinetics/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM/diff /kinetics/chain/kinetics/CaM/CaM REAC A B addmsg /kinetics/CaM/CaM/diff /kinetics/chain/kinetics/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics/CaM/CaM /kinetics/chain/kinetics/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM /kinetics/chain/kinetics/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca3 /kinetics/chain/kinetics/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca4 /kinetics/chain/kinetics/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics/Ca /kinetics/chain/kinetics/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics/CaM/CaM-Ca3/diff /kinetics/chain/kinetics/CaM/CaM-Ca3 REAC A B addmsg /kinetics/CaM/CaM-Ca3/diff /kinetics/chain/kinetics/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics/CaM/CaM-Ca3 /kinetics/chain/kinetics/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca3 /kinetics/chain/kinetics/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics/Ras/CaM-bind-GEF /kinetics/chain/kinetics/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics/PKM/trigger_PKM /kinetics/chain/kinetics/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-Ca4/diff /kinetics/chain/kinetics/CaM/CaM-Ca4 REAC A B addmsg /kinetics/CaM/CaM-Ca4/diff /kinetics/chain/kinetics/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics/CaM/CaM-Ca4 /kinetics/chain/kinetics/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 /kinetics/chain/kinetics/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics/CaM/CaM /kinetics/chain/kinetics/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca /kinetics/chain/kinetics/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics/Ca /kinetics/chain/kinetics/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics/CaM/CaM-Ca2/diff /kinetics/chain/kinetics/CaM/CaM-Ca2 REAC A B addmsg /kinetics/CaM/CaM-Ca2/diff /kinetics/chain/kinetics/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics/CaM/CaM-Ca2 /kinetics/chain/kinetics/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca2 /kinetics/chain/kinetics/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca3 /kinetics/chain/kinetics/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca2 /kinetics/chain/kinetics/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics/Ca /kinetics/chain/kinetics/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca2 /kinetics/chain/kinetics/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca /kinetics/chain/kinetics/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics/Ca /kinetics/chain/kinetics/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM-bind-Ca /kinetics/chain/kinetics/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-Ca/diff /kinetics/chain/kinetics/CaM/CaM-Ca REAC A B addmsg /kinetics/CaM/CaM-Ca/diff /kinetics/chain/kinetics/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics/CaM/CaM-Ca /kinetics/chain/kinetics/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca /kinetics/chain/kinetics/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-act-by-Ca /kinetics/chain/kinetics/Ca REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics/Ca REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-bind-Ca /kinetics/chain/kinetics/Ca REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics/Ca REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics/Ca REAC A B addmsg /kinetics/chain/kinetics/Ca_diff /kinetics/chain/kinetics/Ca REAC B A addmsg /kinetics/chain/kinetics/Ca/diff /kinetics/chain/kinetics/Ca REAC A B addmsg /kinetics/Ca/diff /kinetics/chain/kinetics/Ca REAC B A addmsg /kinetics/chain/kinetics/Ca /kinetics/chain/kinetics/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ca /kinetics/chain/kinetics/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics/MAPK/craf-1 /kinetics/chain/kinetics/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics/Ras/GTP-Ras /kinetics/chain/kinetics/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics/PKM/trigger_PKM /kinetics/chain/kinetics/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics/PKM/Ca_detector/diff /kinetics/chain/kinetics/PKM/Ca_detector REAC A B addmsg /kinetics/PKM/Ca_detector/diff /kinetics/chain/kinetics/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics/PKM/Ca_detector /kinetics/chain/kinetics/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKM/Ca_detector /kinetics/chain/kinetics/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics/PKM/turn_off_activator /kinetics/chain/kinetics/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics/PKM/PKM_synthesis/diff /kinetics/chain/kinetics/PKM/PKM_synthesis REAC A B addmsg /kinetics/PKM/PKM_synthesis/diff /kinetics/chain/kinetics/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics/PKM/PKM_synthesis /kinetics/chain/kinetics/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics/PKM/AA_pool /kinetics/chain/kinetics/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics/PKM/PKM_synthesis /kinetics/chain/kinetics/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKM/PKM_synthesis /kinetics/chain/kinetics/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics/PKC/PKM-zeta /kinetics/chain/kinetics/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics/PKM/degraded_PKM /kinetics/chain/kinetics/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics/PKM/PKM_degradation /kinetics/chain/kinetics/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics/PKM/trigger_PKM /kinetics/chain/kinetics/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics/PKM/Ca.detector_complex REAC A B addmsg /kinetics/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics/PKM/Ca.detector_complex /kinetics/chain/kinetics/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics/PKM/PKM_activator /kinetics/chain/kinetics/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics/PKM/Ca.detector_complex /kinetics/chain/kinetics/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex /kinetics/chain/kinetics/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics/PKM/turn_off_activator /kinetics/chain/kinetics/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics/PKM/PKM_activator/diff /kinetics/chain/kinetics/PKM/PKM_activator REAC A B addmsg /kinetics/PKM/PKM_activator/diff /kinetics/chain/kinetics/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics/PKM/PKM_activator /kinetics/chain/kinetics/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKM/PKM_activator /kinetics/chain/kinetics/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKM/PKM_synthesis /kinetics/chain/kinetics/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics/PKM/PKM_activator /kinetics/chain/kinetics/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca4 /kinetics/chain/kinetics/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics/PKM/Ca_detector /kinetics/chain/kinetics/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics/PKM/Ca.detector_complex /kinetics/chain/kinetics/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics/Ca_diff /kinetics/chain/kinetics/Ca_input REAC A B addmsg /kinetics/chain/kinetics/Ca /kinetics/chain/kinetics/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics/Ca_input /kinetics/chain/kinetics/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[1]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[1]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[1]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-Ca/diff /kinetics/chain/kinetics[1]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[1]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca /kinetics/chain/kinetics[1]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca /kinetics/chain/kinetics[1]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ca /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca /kinetics/chain/kinetics[1]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[1]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[1]/DAG /kinetics/chain/kinetics[1]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca /kinetics/chain/kinetics[1]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[1]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[1]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[1]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/DAG /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG /kinetics/chain/kinetics[1]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-DAG/diff /kinetics/chain/kinetics[1]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[1]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG /kinetics/chain/kinetics[1]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG /kinetics/chain/kinetics[1]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[1]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[1]/PKM/PKM_degradation /kinetics/chain/kinetics[1]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics/PKC/PKM-zeta/diff /kinetics/chain/kinetics[1]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[1]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKM-zeta /kinetics/chain/kinetics[1]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKM-zeta /kinetics/chain/kinetics[1]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[1]/DAG REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG /kinetics/chain/kinetics[1]/DAG REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[1]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[1]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[1]/PKC/PKM-zeta /kinetics/chain/kinetics[1]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[1]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[1]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[1]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[1]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[1]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[1]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[1]/PKC-active /kinetics/chain/kinetics[1]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1 /kinetics/chain/kinetics[1]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC-active /kinetics/chain/kinetics[1]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[1]/Ras/GAP /kinetics/chain/kinetics[1]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC-active /kinetics/chain/kinetics[1]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF /kinetics/chain/kinetics[1]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[1]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[1]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[1]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics/MAPK*/diff /kinetics/chain/kinetics[1]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[1]/MAPK*/diff /kinetics/chain/kinetics[1]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[1]/MAPK* /kinetics/chain/kinetics[1]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1* /kinetics/chain/kinetics[1]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK* /kinetics/chain/kinetics[1]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK* /kinetics/chain/kinetics[1]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[1]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[1]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[1]/Ras-act-unphosph-raf /kinetics/chain/kinetics[1]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[1]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[1]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[1]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[1]/Ras-act-craf /kinetics/chain/kinetics[1]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[1]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[1]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[1]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[1]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[1]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[1]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[1]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[1]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/MAPK/diff /kinetics/chain/kinetics[1]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK/diff /kinetics/chain/kinetics[1]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK /kinetics/chain/kinetics[1]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK /kinetics/chain/kinetics[1]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[1]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[1]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[1]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[1]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[1]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[1]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[1]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[1]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[1]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK* /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK* /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[1]/Ras-act-unphosph-raf /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[1]/Ras-act-craf /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[1]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[1]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[1]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[1]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics/MKP-1/diff /kinetics/chain/kinetics[1]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[1]/MKP-1/diff /kinetics/chain/kinetics[1]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr /kinetics/chain/kinetics[1]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MKP-1 /kinetics/chain/kinetics[1]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK* /kinetics/chain/kinetics[1]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MKP-1 /kinetics/chain/kinetics[1]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[1]/MKP-1 /kinetics/chain/kinetics[1]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MKP-1 /kinetics/chain/kinetics[1]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1* /kinetics/chain/kinetics[1]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[1]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ras/GTP-Ras /kinetics/chain/kinetics[1]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[1]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[1]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[1]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[1]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics/PPhosphatase2A/diff /kinetics/chain/kinetics[1]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/diff /kinetics/chain/kinetics[1]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1* /kinetics/chain/kinetics[1]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A /kinetics/chain/kinetics[1]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK* /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1** /kinetics/chain/kinetics[1]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A /kinetics/chain/kinetics[1]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A /kinetics/chain/kinetics[1]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A /kinetics/chain/kinetics[1]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF /kinetics/chain/kinetics[1]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ras/GEF* /kinetics/chain/kinetics[1]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[1]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[1]/Ras/dephosph-GEF /kinetics/chain/kinetics[1]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[1]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[1]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[1]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics/Ras/inact-GEF/diff /kinetics/chain/kinetics[1]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF/diff /kinetics/chain/kinetics[1]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF /kinetics/chain/kinetics[1]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[1]/Ras/GDP-Ras /kinetics/chain/kinetics[1]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF /kinetics/chain/kinetics[1]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF /kinetics/chain/kinetics[1]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[1]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[1]/Ras/dephosph-GEF /kinetics/chain/kinetics[1]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[1]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics/Ras/GEF*/diff /kinetics/chain/kinetics[1]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[1]/Ras/GEF*/diff /kinetics/chain/kinetics[1]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/GEF* /kinetics/chain/kinetics[1]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[1]/Ras/GDP-Ras /kinetics/chain/kinetics[1]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/GEF* /kinetics/chain/kinetics[1]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/GEF* /kinetics/chain/kinetics[1]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ras-act-craf /kinetics/chain/kinetics[1]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[1]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[1]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[1]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[1]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[1]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[1]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[1]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[1]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[1]/Ras-act-unphosph-raf /kinetics/chain/kinetics[1]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[1]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[1]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[1]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[1]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[1]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[1]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[1]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[1]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[1]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[1]/Ras/GTP-Ras /kinetics/chain/kinetics[1]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/GDP-Ras /kinetics/chain/kinetics[1]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ras/GAP* /kinetics/chain/kinetics[1]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/GAP /kinetics/chain/kinetics[1]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[1]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[1]/Ras/dephosph-GAP /kinetics/chain/kinetics[1]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics/Ras/GAP*/diff /kinetics/chain/kinetics[1]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[1]/Ras/GAP*/diff /kinetics/chain/kinetics[1]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/GAP* /kinetics/chain/kinetics[1]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/GAP* /kinetics/chain/kinetics[1]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[1]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[1]/Ras/dephosph-GAP /kinetics/chain/kinetics[1]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[1]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[1]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics/Ras/GAP/diff /kinetics/chain/kinetics[1]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[1]/Ras/GAP/diff /kinetics/chain/kinetics[1]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/GTP-Ras /kinetics/chain/kinetics[1]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/GAP /kinetics/chain/kinetics[1]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[1]/Ras/GAP /kinetics/chain/kinetics[1]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/GAP /kinetics/chain/kinetics[1]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF /kinetics/chain/kinetics[1]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/CaM-GEF /kinetics/chain/kinetics[1]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 /kinetics/chain/kinetics[1]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[1]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[1]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[1]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics/Ras/CaM-GEF/diff /kinetics/chain/kinetics[1]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[1]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[1]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/GDP-Ras /kinetics/chain/kinetics[1]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/CaM-GEF /kinetics/chain/kinetics[1]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[1]/Ras/CaM-GEF /kinetics/chain/kinetics[1]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/CaM-GEF /kinetics/chain/kinetics[1]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[1]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM/diff /kinetics/chain/kinetics[1]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[1]/CaM/CaM/diff /kinetics/chain/kinetics[1]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM /kinetics/chain/kinetics[1]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM /kinetics/chain/kinetics[1]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca3 /kinetics/chain/kinetics[1]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 /kinetics/chain/kinetics[1]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[1]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[1]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca3 /kinetics/chain/kinetics[1]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca3 /kinetics/chain/kinetics[1]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[1]/PKM/trigger_PKM /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 /kinetics/chain/kinetics[1]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca4 /kinetics/chain/kinetics[1]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/CaM/CaM /kinetics/chain/kinetics[1]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca /kinetics/chain/kinetics[1]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ca /kinetics/chain/kinetics[1]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[1]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[1]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca2 /kinetics/chain/kinetics[1]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca2 /kinetics/chain/kinetics[1]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca3 /kinetics/chain/kinetics[1]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca2 /kinetics/chain/kinetics[1]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca2 /kinetics/chain/kinetics[1]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-Ca/diff /kinetics/chain/kinetics[1]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[1]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[1]/Ca REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[1]/Ca REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[1]/Ca REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[1]/Ca REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[1]/Ca REAC A B addmsg /kinetics/chain/kinetics[1]/Ca_diff /kinetics/chain/kinetics[1]/Ca REAC B A addmsg /kinetics/chain/kinetics/Ca/diff /kinetics/chain/kinetics[1]/Ca REAC B A addmsg /kinetics/chain/kinetics[1]/Ca/diff /kinetics/chain/kinetics[1]/Ca REAC A B addmsg /kinetics/chain/kinetics[1]/Ca /kinetics/chain/kinetics[1]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ca /kinetics/chain/kinetics[1]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1 /kinetics/chain/kinetics[1]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[1]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ras/GTP-Ras /kinetics/chain/kinetics[1]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKM/trigger_PKM /kinetics/chain/kinetics[1]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics/PKM/Ca_detector/diff /kinetics/chain/kinetics[1]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[1]/PKM/Ca_detector/diff /kinetics/chain/kinetics[1]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[1]/PKM/Ca_detector /kinetics/chain/kinetics[1]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKM/Ca_detector /kinetics/chain/kinetics[1]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[1]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[1]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[1]/PKM/turn_off_activator /kinetics/chain/kinetics[1]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[1]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[1]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[1]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[1]/PKM/PKM_synthesis /kinetics/chain/kinetics[1]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[1]/PKM/AA_pool /kinetics/chain/kinetics[1]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKM/PKM_synthesis /kinetics/chain/kinetics[1]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKM/PKM_synthesis /kinetics/chain/kinetics[1]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[1]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[1]/PKC/PKM-zeta /kinetics/chain/kinetics[1]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKM/degraded_PKM /kinetics/chain/kinetics[1]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKM/PKM_degradation /kinetics/chain/kinetics[1]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[1]/PKM/trigger_PKM /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[1]/PKM/PKM_activator /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[1]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[1]/PKM/turn_off_activator /kinetics/chain/kinetics[1]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics/PKM/PKM_activator/diff /kinetics/chain/kinetics[1]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[1]/PKM/PKM_activator/diff /kinetics/chain/kinetics[1]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[1]/PKM/PKM_activator /kinetics/chain/kinetics[1]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKM/PKM_activator /kinetics/chain/kinetics[1]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKM/PKM_synthesis /kinetics/chain/kinetics[1]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKM/PKM_activator /kinetics/chain/kinetics[1]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 /kinetics/chain/kinetics[1]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKM/Ca_detector /kinetics/chain/kinetics[1]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex /kinetics/chain/kinetics[1]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ca_diff /kinetics/chain/kinetics[1]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[1]/Ca /kinetics/chain/kinetics[1]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ca_input /kinetics/chain/kinetics[1]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[2]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[2]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[2]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[2]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[2]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca /kinetics/chain/kinetics[2]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca /kinetics/chain/kinetics[2]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ca /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca /kinetics/chain/kinetics[2]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[2]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[2]/DAG /kinetics/chain/kinetics[2]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca /kinetics/chain/kinetics[2]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[2]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[2]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[2]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/DAG /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG /kinetics/chain/kinetics[2]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[2]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[2]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG /kinetics/chain/kinetics[2]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG /kinetics/chain/kinetics[2]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[2]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[2]/PKM/PKM_degradation /kinetics/chain/kinetics[2]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[2]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[2]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKM-zeta /kinetics/chain/kinetics[2]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKM-zeta /kinetics/chain/kinetics[2]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[2]/DAG REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG /kinetics/chain/kinetics[2]/DAG REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[2]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[2]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[2]/PKC/PKM-zeta /kinetics/chain/kinetics[2]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[2]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[2]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[2]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[2]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[2]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[2]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[2]/PKC-active /kinetics/chain/kinetics[2]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1 /kinetics/chain/kinetics[2]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC-active /kinetics/chain/kinetics[2]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[2]/Ras/GAP /kinetics/chain/kinetics[2]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC-active /kinetics/chain/kinetics[2]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF /kinetics/chain/kinetics[2]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[2]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[2]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[2]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[1]/MAPK*/diff /kinetics/chain/kinetics[2]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[2]/MAPK*/diff /kinetics/chain/kinetics[2]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[2]/MAPK* /kinetics/chain/kinetics[2]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1* /kinetics/chain/kinetics[2]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK* /kinetics/chain/kinetics[2]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK* /kinetics/chain/kinetics[2]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[2]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[2]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[2]/Ras-act-unphosph-raf /kinetics/chain/kinetics[2]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[2]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[2]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[2]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[2]/Ras-act-craf /kinetics/chain/kinetics[2]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[2]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[2]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[2]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[2]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[2]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[2]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[2]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[2]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK/diff /kinetics/chain/kinetics[2]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK/diff /kinetics/chain/kinetics[2]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK /kinetics/chain/kinetics[2]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK /kinetics/chain/kinetics[2]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[2]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[2]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[2]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[2]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[2]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[2]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[2]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[2]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[2]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK* /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK* /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[2]/Ras-act-unphosph-raf /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[2]/Ras-act-craf /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[2]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[2]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[2]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[2]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[1]/MKP-1/diff /kinetics/chain/kinetics[2]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[2]/MKP-1/diff /kinetics/chain/kinetics[2]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr /kinetics/chain/kinetics[2]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MKP-1 /kinetics/chain/kinetics[2]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK* /kinetics/chain/kinetics[2]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MKP-1 /kinetics/chain/kinetics[2]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[2]/MKP-1 /kinetics/chain/kinetics[2]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MKP-1 /kinetics/chain/kinetics[2]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1* /kinetics/chain/kinetics[2]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[2]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ras/GTP-Ras /kinetics/chain/kinetics[2]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[2]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[2]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[2]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[2]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/diff /kinetics/chain/kinetics[2]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/diff /kinetics/chain/kinetics[2]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1* /kinetics/chain/kinetics[2]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A /kinetics/chain/kinetics[2]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK* /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1** /kinetics/chain/kinetics[2]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A /kinetics/chain/kinetics[2]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A /kinetics/chain/kinetics[2]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A /kinetics/chain/kinetics[2]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF /kinetics/chain/kinetics[2]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ras/GEF* /kinetics/chain/kinetics[2]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[2]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[2]/Ras/dephosph-GEF /kinetics/chain/kinetics[2]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[2]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[2]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[2]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF/diff /kinetics/chain/kinetics[2]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF/diff /kinetics/chain/kinetics[2]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF /kinetics/chain/kinetics[2]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[2]/Ras/GDP-Ras /kinetics/chain/kinetics[2]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF /kinetics/chain/kinetics[2]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF /kinetics/chain/kinetics[2]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[2]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[2]/Ras/dephosph-GEF /kinetics/chain/kinetics[2]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[2]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[1]/Ras/GEF*/diff /kinetics/chain/kinetics[2]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[2]/Ras/GEF*/diff /kinetics/chain/kinetics[2]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/GEF* /kinetics/chain/kinetics[2]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[2]/Ras/GDP-Ras /kinetics/chain/kinetics[2]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/GEF* /kinetics/chain/kinetics[2]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/GEF* /kinetics/chain/kinetics[2]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ras-act-craf /kinetics/chain/kinetics[2]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[2]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[2]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[2]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[2]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[2]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[2]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[2]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[2]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[2]/Ras-act-unphosph-raf /kinetics/chain/kinetics[2]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[2]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[2]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[2]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[2]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[2]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[2]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[2]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[2]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[2]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[2]/Ras/GTP-Ras /kinetics/chain/kinetics[2]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/GDP-Ras /kinetics/chain/kinetics[2]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ras/GAP* /kinetics/chain/kinetics[2]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/GAP /kinetics/chain/kinetics[2]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[2]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[2]/Ras/dephosph-GAP /kinetics/chain/kinetics[2]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/GAP*/diff /kinetics/chain/kinetics[2]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[2]/Ras/GAP*/diff /kinetics/chain/kinetics[2]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/GAP* /kinetics/chain/kinetics[2]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/GAP* /kinetics/chain/kinetics[2]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[2]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[2]/Ras/dephosph-GAP /kinetics/chain/kinetics[2]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[2]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[2]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[1]/Ras/GAP/diff /kinetics/chain/kinetics[2]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[2]/Ras/GAP/diff /kinetics/chain/kinetics[2]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/GTP-Ras /kinetics/chain/kinetics[2]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/GAP /kinetics/chain/kinetics[2]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[2]/Ras/GAP /kinetics/chain/kinetics[2]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/GAP /kinetics/chain/kinetics[2]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF /kinetics/chain/kinetics[2]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/CaM-GEF /kinetics/chain/kinetics[2]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca4 /kinetics/chain/kinetics[2]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[2]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[2]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[2]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[1]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[2]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[2]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[2]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/GDP-Ras /kinetics/chain/kinetics[2]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/CaM-GEF /kinetics/chain/kinetics[2]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[2]/Ras/CaM-GEF /kinetics/chain/kinetics[2]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/CaM-GEF /kinetics/chain/kinetics[2]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[2]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM/diff /kinetics/chain/kinetics[2]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[2]/CaM/CaM/diff /kinetics/chain/kinetics[2]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM /kinetics/chain/kinetics[2]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM /kinetics/chain/kinetics[2]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca3 /kinetics/chain/kinetics[2]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca4 /kinetics/chain/kinetics[2]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[2]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[2]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca3 /kinetics/chain/kinetics[2]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca3 /kinetics/chain/kinetics[2]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[2]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[2]/PKM/trigger_PKM /kinetics/chain/kinetics[2]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[2]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[2]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca4 /kinetics/chain/kinetics[2]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca4 /kinetics/chain/kinetics[2]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/CaM/CaM /kinetics/chain/kinetics[2]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca /kinetics/chain/kinetics[2]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ca /kinetics/chain/kinetics[2]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[2]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[2]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca2 /kinetics/chain/kinetics[2]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca2 /kinetics/chain/kinetics[2]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca3 /kinetics/chain/kinetics[2]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca2 /kinetics/chain/kinetics[2]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca2 /kinetics/chain/kinetics[2]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[2]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[2]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[2]/Ca REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[2]/Ca REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[2]/Ca REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[2]/Ca REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[2]/Ca REAC A B addmsg /kinetics/chain/kinetics[2]/Ca_diff /kinetics/chain/kinetics[2]/Ca REAC B A addmsg /kinetics/chain/kinetics[1]/Ca/diff /kinetics/chain/kinetics[2]/Ca REAC B A addmsg /kinetics/chain/kinetics[2]/Ca/diff /kinetics/chain/kinetics[2]/Ca REAC A B addmsg /kinetics/chain/kinetics[2]/Ca /kinetics/chain/kinetics[2]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ca /kinetics/chain/kinetics[2]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1 /kinetics/chain/kinetics[2]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[2]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ras/GTP-Ras /kinetics/chain/kinetics[2]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKM/trigger_PKM /kinetics/chain/kinetics[2]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[1]/PKM/Ca_detector/diff /kinetics/chain/kinetics[2]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[2]/PKM/Ca_detector/diff /kinetics/chain/kinetics[2]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[2]/PKM/Ca_detector /kinetics/chain/kinetics[2]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKM/Ca_detector /kinetics/chain/kinetics[2]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[2]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[2]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[2]/PKM/turn_off_activator /kinetics/chain/kinetics[2]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[1]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[2]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[2]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[2]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[2]/PKM/PKM_synthesis /kinetics/chain/kinetics[2]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[2]/PKM/AA_pool /kinetics/chain/kinetics[2]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKM/PKM_synthesis /kinetics/chain/kinetics[2]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKM/PKM_synthesis /kinetics/chain/kinetics[2]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[2]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[2]/PKC/PKM-zeta /kinetics/chain/kinetics[2]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKM/degraded_PKM /kinetics/chain/kinetics[2]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKM/PKM_degradation /kinetics/chain/kinetics[2]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[2]/PKM/trigger_PKM /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[2]/PKM/PKM_activator /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[2]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[2]/PKM/turn_off_activator /kinetics/chain/kinetics[2]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[1]/PKM/PKM_activator/diff /kinetics/chain/kinetics[2]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[2]/PKM/PKM_activator/diff /kinetics/chain/kinetics[2]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[2]/PKM/PKM_activator /kinetics/chain/kinetics[2]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKM/PKM_activator /kinetics/chain/kinetics[2]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKM/PKM_synthesis /kinetics/chain/kinetics[2]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKM/PKM_activator /kinetics/chain/kinetics[2]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca4 /kinetics/chain/kinetics[2]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKM/Ca_detector /kinetics/chain/kinetics[2]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex /kinetics/chain/kinetics[2]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ca_diff /kinetics/chain/kinetics[2]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[2]/Ca /kinetics/chain/kinetics[2]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ca_input /kinetics/chain/kinetics[2]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[3]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[3]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[3]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[3]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[3]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca /kinetics/chain/kinetics[3]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca /kinetics/chain/kinetics[3]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ca /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca /kinetics/chain/kinetics[3]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[3]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[3]/DAG /kinetics/chain/kinetics[3]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca /kinetics/chain/kinetics[3]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[3]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[3]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[3]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/DAG /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG /kinetics/chain/kinetics[3]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[3]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[3]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG /kinetics/chain/kinetics[3]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG /kinetics/chain/kinetics[3]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[3]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[3]/PKM/PKM_degradation /kinetics/chain/kinetics[3]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[3]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[3]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKM-zeta /kinetics/chain/kinetics[3]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKM-zeta /kinetics/chain/kinetics[3]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[3]/DAG REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG /kinetics/chain/kinetics[3]/DAG REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[3]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[3]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[3]/PKC/PKM-zeta /kinetics/chain/kinetics[3]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[3]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[3]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[3]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[3]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[3]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[3]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[3]/PKC-active /kinetics/chain/kinetics[3]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1 /kinetics/chain/kinetics[3]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC-active /kinetics/chain/kinetics[3]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[3]/Ras/GAP /kinetics/chain/kinetics[3]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC-active /kinetics/chain/kinetics[3]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF /kinetics/chain/kinetics[3]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[3]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[3]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[3]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[2]/MAPK*/diff /kinetics/chain/kinetics[3]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[3]/MAPK*/diff /kinetics/chain/kinetics[3]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[3]/MAPK* /kinetics/chain/kinetics[3]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1* /kinetics/chain/kinetics[3]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK* /kinetics/chain/kinetics[3]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK* /kinetics/chain/kinetics[3]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[3]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[3]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[3]/Ras-act-unphosph-raf /kinetics/chain/kinetics[3]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[3]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[3]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[3]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[3]/Ras-act-craf /kinetics/chain/kinetics[3]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[3]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[3]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[3]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[3]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[3]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[3]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[3]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[3]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK/diff /kinetics/chain/kinetics[3]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK/diff /kinetics/chain/kinetics[3]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK /kinetics/chain/kinetics[3]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK /kinetics/chain/kinetics[3]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[3]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[3]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[3]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[3]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[3]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[3]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[3]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[3]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[3]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK* /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK* /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[3]/Ras-act-unphosph-raf /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[3]/Ras-act-craf /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[3]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[3]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[3]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[3]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[2]/MKP-1/diff /kinetics/chain/kinetics[3]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[3]/MKP-1/diff /kinetics/chain/kinetics[3]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr /kinetics/chain/kinetics[3]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MKP-1 /kinetics/chain/kinetics[3]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK* /kinetics/chain/kinetics[3]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MKP-1 /kinetics/chain/kinetics[3]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[3]/MKP-1 /kinetics/chain/kinetics[3]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MKP-1 /kinetics/chain/kinetics[3]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1* /kinetics/chain/kinetics[3]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[3]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ras/GTP-Ras /kinetics/chain/kinetics[3]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[3]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[3]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[3]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[3]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/diff /kinetics/chain/kinetics[3]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/diff /kinetics/chain/kinetics[3]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1* /kinetics/chain/kinetics[3]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A /kinetics/chain/kinetics[3]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK* /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1** /kinetics/chain/kinetics[3]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A /kinetics/chain/kinetics[3]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A /kinetics/chain/kinetics[3]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A /kinetics/chain/kinetics[3]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF /kinetics/chain/kinetics[3]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ras/GEF* /kinetics/chain/kinetics[3]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[3]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[3]/Ras/dephosph-GEF /kinetics/chain/kinetics[3]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[3]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[3]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[3]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF/diff /kinetics/chain/kinetics[3]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF/diff /kinetics/chain/kinetics[3]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF /kinetics/chain/kinetics[3]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[3]/Ras/GDP-Ras /kinetics/chain/kinetics[3]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF /kinetics/chain/kinetics[3]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF /kinetics/chain/kinetics[3]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[3]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[3]/Ras/dephosph-GEF /kinetics/chain/kinetics[3]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[3]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[2]/Ras/GEF*/diff /kinetics/chain/kinetics[3]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[3]/Ras/GEF*/diff /kinetics/chain/kinetics[3]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/GEF* /kinetics/chain/kinetics[3]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[3]/Ras/GDP-Ras /kinetics/chain/kinetics[3]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/GEF* /kinetics/chain/kinetics[3]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/GEF* /kinetics/chain/kinetics[3]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ras-act-craf /kinetics/chain/kinetics[3]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[3]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[3]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[3]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[3]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[3]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[3]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[3]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[3]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[3]/Ras-act-unphosph-raf /kinetics/chain/kinetics[3]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[3]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[3]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[3]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[3]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[3]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[3]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[3]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[3]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[3]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[3]/Ras/GTP-Ras /kinetics/chain/kinetics[3]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/GDP-Ras /kinetics/chain/kinetics[3]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ras/GAP* /kinetics/chain/kinetics[3]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/GAP /kinetics/chain/kinetics[3]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[3]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[3]/Ras/dephosph-GAP /kinetics/chain/kinetics[3]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/GAP*/diff /kinetics/chain/kinetics[3]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[3]/Ras/GAP*/diff /kinetics/chain/kinetics[3]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/GAP* /kinetics/chain/kinetics[3]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/GAP* /kinetics/chain/kinetics[3]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[3]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[3]/Ras/dephosph-GAP /kinetics/chain/kinetics[3]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[3]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[3]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[2]/Ras/GAP/diff /kinetics/chain/kinetics[3]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[3]/Ras/GAP/diff /kinetics/chain/kinetics[3]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/GTP-Ras /kinetics/chain/kinetics[3]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/GAP /kinetics/chain/kinetics[3]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[3]/Ras/GAP /kinetics/chain/kinetics[3]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/GAP /kinetics/chain/kinetics[3]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF /kinetics/chain/kinetics[3]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/CaM-GEF /kinetics/chain/kinetics[3]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca4 /kinetics/chain/kinetics[3]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[3]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[3]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[3]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[2]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[3]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[3]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[3]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/GDP-Ras /kinetics/chain/kinetics[3]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/CaM-GEF /kinetics/chain/kinetics[3]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[3]/Ras/CaM-GEF /kinetics/chain/kinetics[3]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/CaM-GEF /kinetics/chain/kinetics[3]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[3]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM/diff /kinetics/chain/kinetics[3]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[3]/CaM/CaM/diff /kinetics/chain/kinetics[3]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM /kinetics/chain/kinetics[3]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM /kinetics/chain/kinetics[3]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca3 /kinetics/chain/kinetics[3]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca4 /kinetics/chain/kinetics[3]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[3]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[3]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca3 /kinetics/chain/kinetics[3]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca3 /kinetics/chain/kinetics[3]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[3]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[3]/PKM/trigger_PKM /kinetics/chain/kinetics[3]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[3]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[3]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca4 /kinetics/chain/kinetics[3]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca4 /kinetics/chain/kinetics[3]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/CaM/CaM /kinetics/chain/kinetics[3]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca /kinetics/chain/kinetics[3]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ca /kinetics/chain/kinetics[3]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[3]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[3]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca2 /kinetics/chain/kinetics[3]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca2 /kinetics/chain/kinetics[3]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca3 /kinetics/chain/kinetics[3]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca2 /kinetics/chain/kinetics[3]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca2 /kinetics/chain/kinetics[3]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[3]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[3]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[3]/Ca REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[3]/Ca REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[3]/Ca REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[3]/Ca REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[3]/Ca REAC A B addmsg /kinetics/chain/kinetics[3]/Ca_diff /kinetics/chain/kinetics[3]/Ca REAC B A addmsg /kinetics/chain/kinetics[2]/Ca/diff /kinetics/chain/kinetics[3]/Ca REAC B A addmsg /kinetics/chain/kinetics[3]/Ca/diff /kinetics/chain/kinetics[3]/Ca REAC A B addmsg /kinetics/chain/kinetics[3]/Ca /kinetics/chain/kinetics[3]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ca /kinetics/chain/kinetics[3]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1 /kinetics/chain/kinetics[3]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[3]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ras/GTP-Ras /kinetics/chain/kinetics[3]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKM/trigger_PKM /kinetics/chain/kinetics[3]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[2]/PKM/Ca_detector/diff /kinetics/chain/kinetics[3]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[3]/PKM/Ca_detector/diff /kinetics/chain/kinetics[3]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[3]/PKM/Ca_detector /kinetics/chain/kinetics[3]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKM/Ca_detector /kinetics/chain/kinetics[3]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[3]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[3]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[3]/PKM/turn_off_activator /kinetics/chain/kinetics[3]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[2]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[3]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[3]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[3]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[3]/PKM/PKM_synthesis /kinetics/chain/kinetics[3]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[3]/PKM/AA_pool /kinetics/chain/kinetics[3]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKM/PKM_synthesis /kinetics/chain/kinetics[3]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKM/PKM_synthesis /kinetics/chain/kinetics[3]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[3]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[3]/PKC/PKM-zeta /kinetics/chain/kinetics[3]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKM/degraded_PKM /kinetics/chain/kinetics[3]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKM/PKM_degradation /kinetics/chain/kinetics[3]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[3]/PKM/trigger_PKM /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[3]/PKM/PKM_activator /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[3]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[3]/PKM/turn_off_activator /kinetics/chain/kinetics[3]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[2]/PKM/PKM_activator/diff /kinetics/chain/kinetics[3]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[3]/PKM/PKM_activator/diff /kinetics/chain/kinetics[3]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[3]/PKM/PKM_activator /kinetics/chain/kinetics[3]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKM/PKM_activator /kinetics/chain/kinetics[3]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKM/PKM_synthesis /kinetics/chain/kinetics[3]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKM/PKM_activator /kinetics/chain/kinetics[3]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca4 /kinetics/chain/kinetics[3]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKM/Ca_detector /kinetics/chain/kinetics[3]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex /kinetics/chain/kinetics[3]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ca_diff /kinetics/chain/kinetics[3]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[3]/Ca /kinetics/chain/kinetics[3]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ca_input /kinetics/chain/kinetics[3]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[4]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[4]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[4]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[4]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[4]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca /kinetics/chain/kinetics[4]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca /kinetics/chain/kinetics[4]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ca /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca /kinetics/chain/kinetics[4]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[4]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[4]/DAG /kinetics/chain/kinetics[4]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca /kinetics/chain/kinetics[4]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[4]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[4]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[4]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/DAG /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG /kinetics/chain/kinetics[4]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[4]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[4]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG /kinetics/chain/kinetics[4]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG /kinetics/chain/kinetics[4]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[4]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[4]/PKM/PKM_degradation /kinetics/chain/kinetics[4]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[4]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[4]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKM-zeta /kinetics/chain/kinetics[4]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKM-zeta /kinetics/chain/kinetics[4]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[4]/DAG REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG /kinetics/chain/kinetics[4]/DAG REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[4]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[4]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[4]/PKC/PKM-zeta /kinetics/chain/kinetics[4]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[4]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[4]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[4]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[4]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[4]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[4]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[4]/PKC-active /kinetics/chain/kinetics[4]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1 /kinetics/chain/kinetics[4]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC-active /kinetics/chain/kinetics[4]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[4]/Ras/GAP /kinetics/chain/kinetics[4]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC-active /kinetics/chain/kinetics[4]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF /kinetics/chain/kinetics[4]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[4]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[4]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[4]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[3]/MAPK*/diff /kinetics/chain/kinetics[4]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[4]/MAPK*/diff /kinetics/chain/kinetics[4]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[4]/MAPK* /kinetics/chain/kinetics[4]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1* /kinetics/chain/kinetics[4]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK* /kinetics/chain/kinetics[4]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK* /kinetics/chain/kinetics[4]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[4]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[4]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[4]/Ras-act-unphosph-raf /kinetics/chain/kinetics[4]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[4]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[4]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[4]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[4]/Ras-act-craf /kinetics/chain/kinetics[4]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[4]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[4]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[4]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[4]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[4]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[4]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[4]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[4]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK/diff /kinetics/chain/kinetics[4]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK/diff /kinetics/chain/kinetics[4]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK /kinetics/chain/kinetics[4]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK /kinetics/chain/kinetics[4]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[4]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[4]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[4]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[4]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[4]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[4]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[4]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[4]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[4]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK* /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK* /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[4]/Ras-act-unphosph-raf /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[4]/Ras-act-craf /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[4]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[4]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[4]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[4]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[3]/MKP-1/diff /kinetics/chain/kinetics[4]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[4]/MKP-1/diff /kinetics/chain/kinetics[4]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr /kinetics/chain/kinetics[4]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MKP-1 /kinetics/chain/kinetics[4]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK* /kinetics/chain/kinetics[4]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MKP-1 /kinetics/chain/kinetics[4]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[4]/MKP-1 /kinetics/chain/kinetics[4]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MKP-1 /kinetics/chain/kinetics[4]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1* /kinetics/chain/kinetics[4]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[4]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ras/GTP-Ras /kinetics/chain/kinetics[4]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[4]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[4]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[4]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[4]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/diff /kinetics/chain/kinetics[4]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/diff /kinetics/chain/kinetics[4]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1* /kinetics/chain/kinetics[4]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A /kinetics/chain/kinetics[4]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK* /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1** /kinetics/chain/kinetics[4]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A /kinetics/chain/kinetics[4]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A /kinetics/chain/kinetics[4]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A /kinetics/chain/kinetics[4]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF /kinetics/chain/kinetics[4]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ras/GEF* /kinetics/chain/kinetics[4]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[4]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[4]/Ras/dephosph-GEF /kinetics/chain/kinetics[4]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[4]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[4]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[4]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF/diff /kinetics/chain/kinetics[4]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF/diff /kinetics/chain/kinetics[4]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF /kinetics/chain/kinetics[4]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[4]/Ras/GDP-Ras /kinetics/chain/kinetics[4]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF /kinetics/chain/kinetics[4]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF /kinetics/chain/kinetics[4]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[4]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[4]/Ras/dephosph-GEF /kinetics/chain/kinetics[4]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[4]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[3]/Ras/GEF*/diff /kinetics/chain/kinetics[4]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[4]/Ras/GEF*/diff /kinetics/chain/kinetics[4]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/GEF* /kinetics/chain/kinetics[4]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[4]/Ras/GDP-Ras /kinetics/chain/kinetics[4]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/GEF* /kinetics/chain/kinetics[4]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/GEF* /kinetics/chain/kinetics[4]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ras-act-craf /kinetics/chain/kinetics[4]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[4]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[4]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[4]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[4]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[4]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[4]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[4]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[4]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[4]/Ras-act-unphosph-raf /kinetics/chain/kinetics[4]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[4]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[4]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[4]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[4]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[4]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[4]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[4]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[4]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[4]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[4]/Ras/GTP-Ras /kinetics/chain/kinetics[4]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/GDP-Ras /kinetics/chain/kinetics[4]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ras/GAP* /kinetics/chain/kinetics[4]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/GAP /kinetics/chain/kinetics[4]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[4]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[4]/Ras/dephosph-GAP /kinetics/chain/kinetics[4]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/GAP*/diff /kinetics/chain/kinetics[4]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[4]/Ras/GAP*/diff /kinetics/chain/kinetics[4]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/GAP* /kinetics/chain/kinetics[4]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/GAP* /kinetics/chain/kinetics[4]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[4]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[4]/Ras/dephosph-GAP /kinetics/chain/kinetics[4]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[4]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[4]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[3]/Ras/GAP/diff /kinetics/chain/kinetics[4]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[4]/Ras/GAP/diff /kinetics/chain/kinetics[4]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/GTP-Ras /kinetics/chain/kinetics[4]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/GAP /kinetics/chain/kinetics[4]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[4]/Ras/GAP /kinetics/chain/kinetics[4]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/GAP /kinetics/chain/kinetics[4]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF /kinetics/chain/kinetics[4]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/CaM-GEF /kinetics/chain/kinetics[4]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca4 /kinetics/chain/kinetics[4]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[4]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[4]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[4]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[3]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[4]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[4]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[4]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/GDP-Ras /kinetics/chain/kinetics[4]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/CaM-GEF /kinetics/chain/kinetics[4]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[4]/Ras/CaM-GEF /kinetics/chain/kinetics[4]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/CaM-GEF /kinetics/chain/kinetics[4]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[4]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM/diff /kinetics/chain/kinetics[4]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[4]/CaM/CaM/diff /kinetics/chain/kinetics[4]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM /kinetics/chain/kinetics[4]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM /kinetics/chain/kinetics[4]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca3 /kinetics/chain/kinetics[4]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca4 /kinetics/chain/kinetics[4]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[4]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[4]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca3 /kinetics/chain/kinetics[4]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca3 /kinetics/chain/kinetics[4]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[4]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[4]/PKM/trigger_PKM /kinetics/chain/kinetics[4]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[4]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[4]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca4 /kinetics/chain/kinetics[4]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca4 /kinetics/chain/kinetics[4]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/CaM/CaM /kinetics/chain/kinetics[4]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca /kinetics/chain/kinetics[4]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ca /kinetics/chain/kinetics[4]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[4]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[4]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca2 /kinetics/chain/kinetics[4]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca2 /kinetics/chain/kinetics[4]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca3 /kinetics/chain/kinetics[4]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca2 /kinetics/chain/kinetics[4]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca2 /kinetics/chain/kinetics[4]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[4]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[4]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[4]/Ca REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[4]/Ca REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[4]/Ca REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[4]/Ca REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[4]/Ca REAC A B addmsg /kinetics/chain/kinetics[4]/Ca_diff /kinetics/chain/kinetics[4]/Ca REAC B A addmsg /kinetics/chain/kinetics[3]/Ca/diff /kinetics/chain/kinetics[4]/Ca REAC B A addmsg /kinetics/chain/kinetics[4]/Ca/diff /kinetics/chain/kinetics[4]/Ca REAC A B addmsg /kinetics/chain/kinetics[4]/Ca /kinetics/chain/kinetics[4]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ca /kinetics/chain/kinetics[4]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1 /kinetics/chain/kinetics[4]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[4]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ras/GTP-Ras /kinetics/chain/kinetics[4]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKM/trigger_PKM /kinetics/chain/kinetics[4]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[3]/PKM/Ca_detector/diff /kinetics/chain/kinetics[4]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[4]/PKM/Ca_detector/diff /kinetics/chain/kinetics[4]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[4]/PKM/Ca_detector /kinetics/chain/kinetics[4]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKM/Ca_detector /kinetics/chain/kinetics[4]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[4]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[4]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[4]/PKM/turn_off_activator /kinetics/chain/kinetics[4]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[3]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[4]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[4]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[4]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[4]/PKM/PKM_synthesis /kinetics/chain/kinetics[4]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[4]/PKM/AA_pool /kinetics/chain/kinetics[4]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKM/PKM_synthesis /kinetics/chain/kinetics[4]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKM/PKM_synthesis /kinetics/chain/kinetics[4]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[4]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[4]/PKC/PKM-zeta /kinetics/chain/kinetics[4]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKM/degraded_PKM /kinetics/chain/kinetics[4]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKM/PKM_degradation /kinetics/chain/kinetics[4]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[4]/PKM/trigger_PKM /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[4]/PKM/PKM_activator /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[4]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[4]/PKM/turn_off_activator /kinetics/chain/kinetics[4]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[3]/PKM/PKM_activator/diff /kinetics/chain/kinetics[4]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[4]/PKM/PKM_activator/diff /kinetics/chain/kinetics[4]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[4]/PKM/PKM_activator /kinetics/chain/kinetics[4]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKM/PKM_activator /kinetics/chain/kinetics[4]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKM/PKM_synthesis /kinetics/chain/kinetics[4]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKM/PKM_activator /kinetics/chain/kinetics[4]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca4 /kinetics/chain/kinetics[4]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKM/Ca_detector /kinetics/chain/kinetics[4]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex /kinetics/chain/kinetics[4]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ca_diff /kinetics/chain/kinetics[4]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[4]/Ca /kinetics/chain/kinetics[4]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ca_input /kinetics/chain/kinetics[4]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[5]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[5]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[5]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[5]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[5]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca /kinetics/chain/kinetics[5]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca /kinetics/chain/kinetics[5]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ca /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca /kinetics/chain/kinetics[5]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[5]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[5]/DAG /kinetics/chain/kinetics[5]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca /kinetics/chain/kinetics[5]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[5]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[5]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[5]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/DAG /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG /kinetics/chain/kinetics[5]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[5]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[5]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG /kinetics/chain/kinetics[5]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG /kinetics/chain/kinetics[5]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[5]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[5]/PKM/PKM_degradation /kinetics/chain/kinetics[5]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[5]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[5]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKM-zeta /kinetics/chain/kinetics[5]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKM-zeta /kinetics/chain/kinetics[5]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[5]/DAG REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG /kinetics/chain/kinetics[5]/DAG REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[5]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[5]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[5]/PKC/PKM-zeta /kinetics/chain/kinetics[5]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[5]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[5]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[5]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[5]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[5]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[5]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[5]/PKC-active /kinetics/chain/kinetics[5]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1 /kinetics/chain/kinetics[5]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC-active /kinetics/chain/kinetics[5]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[5]/Ras/GAP /kinetics/chain/kinetics[5]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC-active /kinetics/chain/kinetics[5]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF /kinetics/chain/kinetics[5]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[5]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[5]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[5]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[4]/MAPK*/diff /kinetics/chain/kinetics[5]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[5]/MAPK*/diff /kinetics/chain/kinetics[5]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[5]/MAPK* /kinetics/chain/kinetics[5]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1* /kinetics/chain/kinetics[5]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK* /kinetics/chain/kinetics[5]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK* /kinetics/chain/kinetics[5]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[5]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[5]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[5]/Ras-act-unphosph-raf /kinetics/chain/kinetics[5]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[5]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[5]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[5]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[5]/Ras-act-craf /kinetics/chain/kinetics[5]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[5]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[5]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[5]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[5]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[5]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[5]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[5]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[5]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK/diff /kinetics/chain/kinetics[5]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK/diff /kinetics/chain/kinetics[5]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK /kinetics/chain/kinetics[5]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK /kinetics/chain/kinetics[5]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[5]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[5]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[5]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[5]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[5]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[5]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[5]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[5]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[5]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK* /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK* /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[5]/Ras-act-unphosph-raf /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[5]/Ras-act-craf /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[5]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[5]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[5]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[5]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[4]/MKP-1/diff /kinetics/chain/kinetics[5]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[5]/MKP-1/diff /kinetics/chain/kinetics[5]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr /kinetics/chain/kinetics[5]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MKP-1 /kinetics/chain/kinetics[5]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK* /kinetics/chain/kinetics[5]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MKP-1 /kinetics/chain/kinetics[5]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[5]/MKP-1 /kinetics/chain/kinetics[5]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MKP-1 /kinetics/chain/kinetics[5]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1* /kinetics/chain/kinetics[5]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[5]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ras/GTP-Ras /kinetics/chain/kinetics[5]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[5]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[5]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[5]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[5]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/diff /kinetics/chain/kinetics[5]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/diff /kinetics/chain/kinetics[5]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1* /kinetics/chain/kinetics[5]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A /kinetics/chain/kinetics[5]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK* /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1** /kinetics/chain/kinetics[5]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A /kinetics/chain/kinetics[5]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A /kinetics/chain/kinetics[5]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A /kinetics/chain/kinetics[5]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF /kinetics/chain/kinetics[5]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ras/GEF* /kinetics/chain/kinetics[5]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[5]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[5]/Ras/dephosph-GEF /kinetics/chain/kinetics[5]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[5]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[5]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[5]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF/diff /kinetics/chain/kinetics[5]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF/diff /kinetics/chain/kinetics[5]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF /kinetics/chain/kinetics[5]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[5]/Ras/GDP-Ras /kinetics/chain/kinetics[5]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF /kinetics/chain/kinetics[5]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF /kinetics/chain/kinetics[5]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[5]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[5]/Ras/dephosph-GEF /kinetics/chain/kinetics[5]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[5]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[4]/Ras/GEF*/diff /kinetics/chain/kinetics[5]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[5]/Ras/GEF*/diff /kinetics/chain/kinetics[5]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/GEF* /kinetics/chain/kinetics[5]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[5]/Ras/GDP-Ras /kinetics/chain/kinetics[5]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/GEF* /kinetics/chain/kinetics[5]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/GEF* /kinetics/chain/kinetics[5]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ras-act-craf /kinetics/chain/kinetics[5]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[5]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[5]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[5]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[5]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[5]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[5]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[5]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[5]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[5]/Ras-act-unphosph-raf /kinetics/chain/kinetics[5]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[5]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[5]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[5]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[5]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[5]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[5]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[5]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[5]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[5]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[5]/Ras/GTP-Ras /kinetics/chain/kinetics[5]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/GDP-Ras /kinetics/chain/kinetics[5]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ras/GAP* /kinetics/chain/kinetics[5]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/GAP /kinetics/chain/kinetics[5]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[5]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[5]/Ras/dephosph-GAP /kinetics/chain/kinetics[5]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/GAP*/diff /kinetics/chain/kinetics[5]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[5]/Ras/GAP*/diff /kinetics/chain/kinetics[5]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/GAP* /kinetics/chain/kinetics[5]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/GAP* /kinetics/chain/kinetics[5]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[5]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[5]/Ras/dephosph-GAP /kinetics/chain/kinetics[5]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[5]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[5]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[4]/Ras/GAP/diff /kinetics/chain/kinetics[5]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[5]/Ras/GAP/diff /kinetics/chain/kinetics[5]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/GTP-Ras /kinetics/chain/kinetics[5]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/GAP /kinetics/chain/kinetics[5]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[5]/Ras/GAP /kinetics/chain/kinetics[5]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/GAP /kinetics/chain/kinetics[5]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF /kinetics/chain/kinetics[5]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/CaM-GEF /kinetics/chain/kinetics[5]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca4 /kinetics/chain/kinetics[5]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[5]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[5]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[5]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[4]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[5]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[5]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[5]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/GDP-Ras /kinetics/chain/kinetics[5]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/CaM-GEF /kinetics/chain/kinetics[5]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[5]/Ras/CaM-GEF /kinetics/chain/kinetics[5]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/CaM-GEF /kinetics/chain/kinetics[5]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[5]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM/diff /kinetics/chain/kinetics[5]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[5]/CaM/CaM/diff /kinetics/chain/kinetics[5]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM /kinetics/chain/kinetics[5]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM /kinetics/chain/kinetics[5]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca3 /kinetics/chain/kinetics[5]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca4 /kinetics/chain/kinetics[5]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[5]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[5]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca3 /kinetics/chain/kinetics[5]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca3 /kinetics/chain/kinetics[5]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[5]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[5]/PKM/trigger_PKM /kinetics/chain/kinetics[5]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[5]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[5]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca4 /kinetics/chain/kinetics[5]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 /kinetics/chain/kinetics[5]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/CaM/CaM /kinetics/chain/kinetics[5]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca /kinetics/chain/kinetics[5]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ca /kinetics/chain/kinetics[5]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[5]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[5]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca2 /kinetics/chain/kinetics[5]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca2 /kinetics/chain/kinetics[5]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca3 /kinetics/chain/kinetics[5]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca2 /kinetics/chain/kinetics[5]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca2 /kinetics/chain/kinetics[5]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[5]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[5]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[5]/Ca REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[5]/Ca REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[5]/Ca REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[5]/Ca REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[5]/Ca REAC A B addmsg /kinetics/chain/kinetics[5]/Ca_diff /kinetics/chain/kinetics[5]/Ca REAC B A addmsg /kinetics/chain/kinetics[4]/Ca/diff /kinetics/chain/kinetics[5]/Ca REAC B A addmsg /kinetics/chain/kinetics[5]/Ca/diff /kinetics/chain/kinetics[5]/Ca REAC A B addmsg /kinetics/chain/kinetics[5]/Ca /kinetics/chain/kinetics[5]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ca /kinetics/chain/kinetics[5]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1 /kinetics/chain/kinetics[5]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[5]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ras/GTP-Ras /kinetics/chain/kinetics[5]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKM/trigger_PKM /kinetics/chain/kinetics[5]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[4]/PKM/Ca_detector/diff /kinetics/chain/kinetics[5]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[5]/PKM/Ca_detector/diff /kinetics/chain/kinetics[5]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[5]/PKM/Ca_detector /kinetics/chain/kinetics[5]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKM/Ca_detector /kinetics/chain/kinetics[5]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[5]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[5]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[5]/PKM/turn_off_activator /kinetics/chain/kinetics[5]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[4]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[5]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[5]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[5]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[5]/PKM/PKM_synthesis /kinetics/chain/kinetics[5]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[5]/PKM/AA_pool /kinetics/chain/kinetics[5]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKM/PKM_synthesis /kinetics/chain/kinetics[5]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKM/PKM_synthesis /kinetics/chain/kinetics[5]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[5]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[5]/PKC/PKM-zeta /kinetics/chain/kinetics[5]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKM/degraded_PKM /kinetics/chain/kinetics[5]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKM/PKM_degradation /kinetics/chain/kinetics[5]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[5]/PKM/trigger_PKM /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[5]/PKM/PKM_activator /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[5]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[5]/PKM/turn_off_activator /kinetics/chain/kinetics[5]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[4]/PKM/PKM_activator/diff /kinetics/chain/kinetics[5]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[5]/PKM/PKM_activator/diff /kinetics/chain/kinetics[5]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[5]/PKM/PKM_activator /kinetics/chain/kinetics[5]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKM/PKM_activator /kinetics/chain/kinetics[5]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKM/PKM_synthesis /kinetics/chain/kinetics[5]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKM/PKM_activator /kinetics/chain/kinetics[5]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca4 /kinetics/chain/kinetics[5]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKM/Ca_detector /kinetics/chain/kinetics[5]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex /kinetics/chain/kinetics[5]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ca_diff /kinetics/chain/kinetics[5]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[5]/Ca /kinetics/chain/kinetics[5]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ca_input /kinetics/chain/kinetics[5]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[6]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[6]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[6]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[6]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[6]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca /kinetics/chain/kinetics[6]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca /kinetics/chain/kinetics[6]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ca /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca /kinetics/chain/kinetics[6]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[6]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[6]/DAG /kinetics/chain/kinetics[6]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca /kinetics/chain/kinetics[6]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[6]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[6]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[6]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/DAG /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG /kinetics/chain/kinetics[6]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[6]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[6]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG /kinetics/chain/kinetics[6]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG /kinetics/chain/kinetics[6]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[6]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[6]/PKM/PKM_degradation /kinetics/chain/kinetics[6]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[6]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[6]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKM-zeta /kinetics/chain/kinetics[6]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKM-zeta /kinetics/chain/kinetics[6]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[6]/DAG REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG /kinetics/chain/kinetics[6]/DAG REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[6]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[6]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[6]/PKC/PKM-zeta /kinetics/chain/kinetics[6]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[6]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[6]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[6]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[6]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[6]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[6]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[6]/PKC-active /kinetics/chain/kinetics[6]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1 /kinetics/chain/kinetics[6]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC-active /kinetics/chain/kinetics[6]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[6]/Ras/GAP /kinetics/chain/kinetics[6]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC-active /kinetics/chain/kinetics[6]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF /kinetics/chain/kinetics[6]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[6]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[6]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[6]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[5]/MAPK*/diff /kinetics/chain/kinetics[6]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[6]/MAPK*/diff /kinetics/chain/kinetics[6]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[6]/MAPK* /kinetics/chain/kinetics[6]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1* /kinetics/chain/kinetics[6]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK* /kinetics/chain/kinetics[6]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK* /kinetics/chain/kinetics[6]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[6]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[6]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[6]/Ras-act-unphosph-raf /kinetics/chain/kinetics[6]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[6]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[6]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[6]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[6]/Ras-act-craf /kinetics/chain/kinetics[6]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[6]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[6]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[6]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[6]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[6]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[6]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[6]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[6]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK/diff /kinetics/chain/kinetics[6]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK/diff /kinetics/chain/kinetics[6]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK /kinetics/chain/kinetics[6]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK /kinetics/chain/kinetics[6]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[6]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[6]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[6]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[6]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[6]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[6]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[6]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[6]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[6]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK* /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK* /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[6]/Ras-act-unphosph-raf /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[6]/Ras-act-craf /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[6]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[6]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[6]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[6]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[5]/MKP-1/diff /kinetics/chain/kinetics[6]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[6]/MKP-1/diff /kinetics/chain/kinetics[6]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr /kinetics/chain/kinetics[6]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MKP-1 /kinetics/chain/kinetics[6]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK* /kinetics/chain/kinetics[6]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MKP-1 /kinetics/chain/kinetics[6]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[6]/MKP-1 /kinetics/chain/kinetics[6]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MKP-1 /kinetics/chain/kinetics[6]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1* /kinetics/chain/kinetics[6]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[6]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ras/GTP-Ras /kinetics/chain/kinetics[6]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[6]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[6]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[6]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[6]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/diff /kinetics/chain/kinetics[6]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/diff /kinetics/chain/kinetics[6]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1* /kinetics/chain/kinetics[6]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A /kinetics/chain/kinetics[6]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK* /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1** /kinetics/chain/kinetics[6]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A /kinetics/chain/kinetics[6]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A /kinetics/chain/kinetics[6]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A /kinetics/chain/kinetics[6]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF /kinetics/chain/kinetics[6]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ras/GEF* /kinetics/chain/kinetics[6]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[6]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[6]/Ras/dephosph-GEF /kinetics/chain/kinetics[6]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[6]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[6]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[6]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF/diff /kinetics/chain/kinetics[6]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF/diff /kinetics/chain/kinetics[6]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF /kinetics/chain/kinetics[6]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[6]/Ras/GDP-Ras /kinetics/chain/kinetics[6]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF /kinetics/chain/kinetics[6]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF /kinetics/chain/kinetics[6]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[6]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[6]/Ras/dephosph-GEF /kinetics/chain/kinetics[6]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[6]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[5]/Ras/GEF*/diff /kinetics/chain/kinetics[6]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[6]/Ras/GEF*/diff /kinetics/chain/kinetics[6]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/GEF* /kinetics/chain/kinetics[6]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[6]/Ras/GDP-Ras /kinetics/chain/kinetics[6]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/GEF* /kinetics/chain/kinetics[6]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/GEF* /kinetics/chain/kinetics[6]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ras-act-craf /kinetics/chain/kinetics[6]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[6]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[6]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[6]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[6]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[6]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[6]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[6]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[6]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[6]/Ras-act-unphosph-raf /kinetics/chain/kinetics[6]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[6]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[6]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[6]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[6]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[6]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[6]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[6]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[6]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[6]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[6]/Ras/GTP-Ras /kinetics/chain/kinetics[6]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/GDP-Ras /kinetics/chain/kinetics[6]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ras/GAP* /kinetics/chain/kinetics[6]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/GAP /kinetics/chain/kinetics[6]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[6]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[6]/Ras/dephosph-GAP /kinetics/chain/kinetics[6]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/GAP*/diff /kinetics/chain/kinetics[6]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[6]/Ras/GAP*/diff /kinetics/chain/kinetics[6]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/GAP* /kinetics/chain/kinetics[6]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/GAP* /kinetics/chain/kinetics[6]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[6]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[6]/Ras/dephosph-GAP /kinetics/chain/kinetics[6]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[6]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[6]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[5]/Ras/GAP/diff /kinetics/chain/kinetics[6]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[6]/Ras/GAP/diff /kinetics/chain/kinetics[6]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/GTP-Ras /kinetics/chain/kinetics[6]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/GAP /kinetics/chain/kinetics[6]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[6]/Ras/GAP /kinetics/chain/kinetics[6]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/GAP /kinetics/chain/kinetics[6]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF /kinetics/chain/kinetics[6]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/CaM-GEF /kinetics/chain/kinetics[6]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 /kinetics/chain/kinetics[6]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[6]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[6]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[6]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[5]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[6]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[6]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[6]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/GDP-Ras /kinetics/chain/kinetics[6]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/CaM-GEF /kinetics/chain/kinetics[6]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[6]/Ras/CaM-GEF /kinetics/chain/kinetics[6]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/CaM-GEF /kinetics/chain/kinetics[6]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[6]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM/diff /kinetics/chain/kinetics[6]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[6]/CaM/CaM/diff /kinetics/chain/kinetics[6]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM /kinetics/chain/kinetics[6]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM /kinetics/chain/kinetics[6]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca3 /kinetics/chain/kinetics[6]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 /kinetics/chain/kinetics[6]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[6]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[6]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca3 /kinetics/chain/kinetics[6]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca3 /kinetics/chain/kinetics[6]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[6]/PKM/trigger_PKM /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 /kinetics/chain/kinetics[6]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 /kinetics/chain/kinetics[6]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/CaM/CaM /kinetics/chain/kinetics[6]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca /kinetics/chain/kinetics[6]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ca /kinetics/chain/kinetics[6]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[6]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[6]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca2 /kinetics/chain/kinetics[6]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca2 /kinetics/chain/kinetics[6]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca3 /kinetics/chain/kinetics[6]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca2 /kinetics/chain/kinetics[6]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca2 /kinetics/chain/kinetics[6]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[6]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[6]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[6]/Ca REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[6]/Ca REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[6]/Ca REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[6]/Ca REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[6]/Ca REAC A B addmsg /kinetics/chain/kinetics[6]/Ca_diff /kinetics/chain/kinetics[6]/Ca REAC B A addmsg /kinetics/chain/kinetics[5]/Ca/diff /kinetics/chain/kinetics[6]/Ca REAC B A addmsg /kinetics/chain/kinetics[6]/Ca/diff /kinetics/chain/kinetics[6]/Ca REAC A B addmsg /kinetics/chain/kinetics[6]/Ca /kinetics/chain/kinetics[6]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ca /kinetics/chain/kinetics[6]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1 /kinetics/chain/kinetics[6]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[6]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ras/GTP-Ras /kinetics/chain/kinetics[6]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKM/trigger_PKM /kinetics/chain/kinetics[6]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[5]/PKM/Ca_detector/diff /kinetics/chain/kinetics[6]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[6]/PKM/Ca_detector/diff /kinetics/chain/kinetics[6]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[6]/PKM/Ca_detector /kinetics/chain/kinetics[6]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKM/Ca_detector /kinetics/chain/kinetics[6]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[6]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[6]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[6]/PKM/turn_off_activator /kinetics/chain/kinetics[6]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[5]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[6]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[6]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[6]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[6]/PKM/PKM_synthesis /kinetics/chain/kinetics[6]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[6]/PKM/AA_pool /kinetics/chain/kinetics[6]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKM/PKM_synthesis /kinetics/chain/kinetics[6]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKM/PKM_synthesis /kinetics/chain/kinetics[6]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[6]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[6]/PKC/PKM-zeta /kinetics/chain/kinetics[6]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKM/degraded_PKM /kinetics/chain/kinetics[6]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKM/PKM_degradation /kinetics/chain/kinetics[6]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[6]/PKM/trigger_PKM /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[6]/PKM/PKM_activator /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[6]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[6]/PKM/turn_off_activator /kinetics/chain/kinetics[6]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[5]/PKM/PKM_activator/diff /kinetics/chain/kinetics[6]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[6]/PKM/PKM_activator/diff /kinetics/chain/kinetics[6]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[6]/PKM/PKM_activator /kinetics/chain/kinetics[6]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKM/PKM_activator /kinetics/chain/kinetics[6]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKM/PKM_synthesis /kinetics/chain/kinetics[6]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKM/PKM_activator /kinetics/chain/kinetics[6]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 /kinetics/chain/kinetics[6]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKM/Ca_detector /kinetics/chain/kinetics[6]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex /kinetics/chain/kinetics[6]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ca_diff /kinetics/chain/kinetics[6]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[6]/Ca /kinetics/chain/kinetics[6]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ca_input /kinetics/chain/kinetics[6]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[7]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[7]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[7]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[7]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[7]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca /kinetics/chain/kinetics[7]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca /kinetics/chain/kinetics[7]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ca /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca /kinetics/chain/kinetics[7]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[7]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[7]/DAG /kinetics/chain/kinetics[7]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca /kinetics/chain/kinetics[7]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[7]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[7]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[7]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/DAG /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG /kinetics/chain/kinetics[7]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[7]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[7]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG /kinetics/chain/kinetics[7]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG /kinetics/chain/kinetics[7]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[7]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[7]/PKM/PKM_degradation /kinetics/chain/kinetics[7]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[7]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[7]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKM-zeta /kinetics/chain/kinetics[7]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKM-zeta /kinetics/chain/kinetics[7]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[7]/DAG REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG /kinetics/chain/kinetics[7]/DAG REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[7]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[7]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[7]/PKC/PKM-zeta /kinetics/chain/kinetics[7]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[7]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[7]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[7]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[7]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[7]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[7]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[7]/PKC-active /kinetics/chain/kinetics[7]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1 /kinetics/chain/kinetics[7]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC-active /kinetics/chain/kinetics[7]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[7]/Ras/GAP /kinetics/chain/kinetics[7]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC-active /kinetics/chain/kinetics[7]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF /kinetics/chain/kinetics[7]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[7]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[7]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[7]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[6]/MAPK*/diff /kinetics/chain/kinetics[7]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[7]/MAPK*/diff /kinetics/chain/kinetics[7]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[7]/MAPK* /kinetics/chain/kinetics[7]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1* /kinetics/chain/kinetics[7]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK* /kinetics/chain/kinetics[7]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK* /kinetics/chain/kinetics[7]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[7]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[7]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[7]/Ras-act-unphosph-raf /kinetics/chain/kinetics[7]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[7]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[7]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[7]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[7]/Ras-act-craf /kinetics/chain/kinetics[7]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[7]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[7]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[7]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[7]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[7]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[7]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[7]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[7]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK/diff /kinetics/chain/kinetics[7]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK/diff /kinetics/chain/kinetics[7]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK /kinetics/chain/kinetics[7]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK /kinetics/chain/kinetics[7]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[7]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[7]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[7]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[7]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[7]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[7]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[7]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[7]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[7]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK* /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK* /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[7]/Ras-act-unphosph-raf /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[7]/Ras-act-craf /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[7]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[7]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[7]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[7]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[6]/MKP-1/diff /kinetics/chain/kinetics[7]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[7]/MKP-1/diff /kinetics/chain/kinetics[7]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr /kinetics/chain/kinetics[7]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MKP-1 /kinetics/chain/kinetics[7]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK* /kinetics/chain/kinetics[7]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MKP-1 /kinetics/chain/kinetics[7]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[7]/MKP-1 /kinetics/chain/kinetics[7]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MKP-1 /kinetics/chain/kinetics[7]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1* /kinetics/chain/kinetics[7]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[7]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ras/GTP-Ras /kinetics/chain/kinetics[7]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[7]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[7]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[7]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[7]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/diff /kinetics/chain/kinetics[7]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/diff /kinetics/chain/kinetics[7]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1* /kinetics/chain/kinetics[7]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A /kinetics/chain/kinetics[7]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK* /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1** /kinetics/chain/kinetics[7]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A /kinetics/chain/kinetics[7]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A /kinetics/chain/kinetics[7]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A /kinetics/chain/kinetics[7]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF /kinetics/chain/kinetics[7]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ras/GEF* /kinetics/chain/kinetics[7]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[7]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[7]/Ras/dephosph-GEF /kinetics/chain/kinetics[7]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[7]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[7]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[7]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF/diff /kinetics/chain/kinetics[7]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF/diff /kinetics/chain/kinetics[7]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF /kinetics/chain/kinetics[7]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[7]/Ras/GDP-Ras /kinetics/chain/kinetics[7]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF /kinetics/chain/kinetics[7]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF /kinetics/chain/kinetics[7]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[7]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[7]/Ras/dephosph-GEF /kinetics/chain/kinetics[7]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[7]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[6]/Ras/GEF*/diff /kinetics/chain/kinetics[7]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[7]/Ras/GEF*/diff /kinetics/chain/kinetics[7]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/GEF* /kinetics/chain/kinetics[7]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[7]/Ras/GDP-Ras /kinetics/chain/kinetics[7]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/GEF* /kinetics/chain/kinetics[7]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/GEF* /kinetics/chain/kinetics[7]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ras-act-craf /kinetics/chain/kinetics[7]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[7]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[7]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[7]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[7]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[7]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[7]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[7]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[7]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[7]/Ras-act-unphosph-raf /kinetics/chain/kinetics[7]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[7]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[7]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[7]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[7]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[7]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[7]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[7]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[7]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[7]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[7]/Ras/GTP-Ras /kinetics/chain/kinetics[7]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/GDP-Ras /kinetics/chain/kinetics[7]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ras/GAP* /kinetics/chain/kinetics[7]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/GAP /kinetics/chain/kinetics[7]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[7]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[7]/Ras/dephosph-GAP /kinetics/chain/kinetics[7]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/GAP*/diff /kinetics/chain/kinetics[7]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[7]/Ras/GAP*/diff /kinetics/chain/kinetics[7]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/GAP* /kinetics/chain/kinetics[7]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/GAP* /kinetics/chain/kinetics[7]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[7]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[7]/Ras/dephosph-GAP /kinetics/chain/kinetics[7]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[7]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[7]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[6]/Ras/GAP/diff /kinetics/chain/kinetics[7]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[7]/Ras/GAP/diff /kinetics/chain/kinetics[7]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/GTP-Ras /kinetics/chain/kinetics[7]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/GAP /kinetics/chain/kinetics[7]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[7]/Ras/GAP /kinetics/chain/kinetics[7]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/GAP /kinetics/chain/kinetics[7]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF /kinetics/chain/kinetics[7]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/CaM-GEF /kinetics/chain/kinetics[7]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 /kinetics/chain/kinetics[7]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[7]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[7]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[7]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[6]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[7]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[7]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[7]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/GDP-Ras /kinetics/chain/kinetics[7]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/CaM-GEF /kinetics/chain/kinetics[7]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[7]/Ras/CaM-GEF /kinetics/chain/kinetics[7]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/CaM-GEF /kinetics/chain/kinetics[7]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[7]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM/diff /kinetics/chain/kinetics[7]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[7]/CaM/CaM/diff /kinetics/chain/kinetics[7]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM /kinetics/chain/kinetics[7]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM /kinetics/chain/kinetics[7]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca3 /kinetics/chain/kinetics[7]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 /kinetics/chain/kinetics[7]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[7]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[7]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca3 /kinetics/chain/kinetics[7]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca3 /kinetics/chain/kinetics[7]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[7]/PKM/trigger_PKM /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 /kinetics/chain/kinetics[7]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca4 /kinetics/chain/kinetics[7]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/CaM/CaM /kinetics/chain/kinetics[7]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca /kinetics/chain/kinetics[7]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ca /kinetics/chain/kinetics[7]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[7]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[7]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca2 /kinetics/chain/kinetics[7]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca2 /kinetics/chain/kinetics[7]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca3 /kinetics/chain/kinetics[7]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca2 /kinetics/chain/kinetics[7]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca2 /kinetics/chain/kinetics[7]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[7]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[7]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[7]/Ca REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[7]/Ca REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[7]/Ca REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[7]/Ca REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[7]/Ca REAC A B addmsg /kinetics/chain/kinetics[7]/Ca_diff /kinetics/chain/kinetics[7]/Ca REAC B A addmsg /kinetics/chain/kinetics[6]/Ca/diff /kinetics/chain/kinetics[7]/Ca REAC B A addmsg /kinetics/chain/kinetics[7]/Ca/diff /kinetics/chain/kinetics[7]/Ca REAC A B addmsg /kinetics/chain/kinetics[7]/Ca /kinetics/chain/kinetics[7]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ca /kinetics/chain/kinetics[7]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1 /kinetics/chain/kinetics[7]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[7]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ras/GTP-Ras /kinetics/chain/kinetics[7]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKM/trigger_PKM /kinetics/chain/kinetics[7]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[6]/PKM/Ca_detector/diff /kinetics/chain/kinetics[7]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[7]/PKM/Ca_detector/diff /kinetics/chain/kinetics[7]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[7]/PKM/Ca_detector /kinetics/chain/kinetics[7]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKM/Ca_detector /kinetics/chain/kinetics[7]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[7]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[7]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[7]/PKM/turn_off_activator /kinetics/chain/kinetics[7]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[6]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[7]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[7]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[7]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[7]/PKM/PKM_synthesis /kinetics/chain/kinetics[7]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[7]/PKM/AA_pool /kinetics/chain/kinetics[7]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKM/PKM_synthesis /kinetics/chain/kinetics[7]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKM/PKM_synthesis /kinetics/chain/kinetics[7]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[7]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[7]/PKC/PKM-zeta /kinetics/chain/kinetics[7]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKM/degraded_PKM /kinetics/chain/kinetics[7]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKM/PKM_degradation /kinetics/chain/kinetics[7]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[7]/PKM/trigger_PKM /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[7]/PKM/PKM_activator /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[7]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[7]/PKM/turn_off_activator /kinetics/chain/kinetics[7]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[6]/PKM/PKM_activator/diff /kinetics/chain/kinetics[7]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[7]/PKM/PKM_activator/diff /kinetics/chain/kinetics[7]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[7]/PKM/PKM_activator /kinetics/chain/kinetics[7]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKM/PKM_activator /kinetics/chain/kinetics[7]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKM/PKM_synthesis /kinetics/chain/kinetics[7]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKM/PKM_activator /kinetics/chain/kinetics[7]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 /kinetics/chain/kinetics[7]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKM/Ca_detector /kinetics/chain/kinetics[7]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex /kinetics/chain/kinetics[7]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ca_diff /kinetics/chain/kinetics[7]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[7]/Ca /kinetics/chain/kinetics[7]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ca_input /kinetics/chain/kinetics[7]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[8]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[8]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[8]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[8]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[8]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca /kinetics/chain/kinetics[8]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca /kinetics/chain/kinetics[8]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ca /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca /kinetics/chain/kinetics[8]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[8]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[8]/DAG /kinetics/chain/kinetics[8]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca /kinetics/chain/kinetics[8]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[8]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[8]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[8]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/DAG /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG /kinetics/chain/kinetics[8]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[8]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[8]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG /kinetics/chain/kinetics[8]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG /kinetics/chain/kinetics[8]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[8]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[8]/PKM/PKM_degradation /kinetics/chain/kinetics[8]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[8]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[8]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKM-zeta /kinetics/chain/kinetics[8]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKM-zeta /kinetics/chain/kinetics[8]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[8]/DAG REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG /kinetics/chain/kinetics[8]/DAG REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[8]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[8]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[8]/PKC/PKM-zeta /kinetics/chain/kinetics[8]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[8]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[8]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[8]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[8]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[8]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[8]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[8]/PKC-active /kinetics/chain/kinetics[8]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1 /kinetics/chain/kinetics[8]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC-active /kinetics/chain/kinetics[8]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[8]/Ras/GAP /kinetics/chain/kinetics[8]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC-active /kinetics/chain/kinetics[8]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF /kinetics/chain/kinetics[8]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[8]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[8]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[8]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[7]/MAPK*/diff /kinetics/chain/kinetics[8]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[8]/MAPK*/diff /kinetics/chain/kinetics[8]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[8]/MAPK* /kinetics/chain/kinetics[8]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1* /kinetics/chain/kinetics[8]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK* /kinetics/chain/kinetics[8]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK* /kinetics/chain/kinetics[8]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[8]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[8]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[8]/Ras-act-unphosph-raf /kinetics/chain/kinetics[8]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[8]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[8]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[8]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[8]/Ras-act-craf /kinetics/chain/kinetics[8]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[8]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[8]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[8]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[8]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[8]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[8]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[8]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[8]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK/diff /kinetics/chain/kinetics[8]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK/diff /kinetics/chain/kinetics[8]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK /kinetics/chain/kinetics[8]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK /kinetics/chain/kinetics[8]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[8]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[8]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[8]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[8]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[8]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[8]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[8]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[8]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[8]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK* /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK* /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[8]/Ras-act-unphosph-raf /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[8]/Ras-act-craf /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[8]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[8]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[8]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[8]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[7]/MKP-1/diff /kinetics/chain/kinetics[8]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[8]/MKP-1/diff /kinetics/chain/kinetics[8]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr /kinetics/chain/kinetics[8]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MKP-1 /kinetics/chain/kinetics[8]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK* /kinetics/chain/kinetics[8]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MKP-1 /kinetics/chain/kinetics[8]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[8]/MKP-1 /kinetics/chain/kinetics[8]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MKP-1 /kinetics/chain/kinetics[8]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1* /kinetics/chain/kinetics[8]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[8]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ras/GTP-Ras /kinetics/chain/kinetics[8]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[8]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[8]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[8]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[8]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/diff /kinetics/chain/kinetics[8]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/diff /kinetics/chain/kinetics[8]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1* /kinetics/chain/kinetics[8]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A /kinetics/chain/kinetics[8]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK* /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1** /kinetics/chain/kinetics[8]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A /kinetics/chain/kinetics[8]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A /kinetics/chain/kinetics[8]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A /kinetics/chain/kinetics[8]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF /kinetics/chain/kinetics[8]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ras/GEF* /kinetics/chain/kinetics[8]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[8]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[8]/Ras/dephosph-GEF /kinetics/chain/kinetics[8]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[8]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[8]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[8]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF/diff /kinetics/chain/kinetics[8]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF/diff /kinetics/chain/kinetics[8]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF /kinetics/chain/kinetics[8]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[8]/Ras/GDP-Ras /kinetics/chain/kinetics[8]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF /kinetics/chain/kinetics[8]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF /kinetics/chain/kinetics[8]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[8]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[8]/Ras/dephosph-GEF /kinetics/chain/kinetics[8]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[8]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[7]/Ras/GEF*/diff /kinetics/chain/kinetics[8]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[8]/Ras/GEF*/diff /kinetics/chain/kinetics[8]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/GEF* /kinetics/chain/kinetics[8]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[8]/Ras/GDP-Ras /kinetics/chain/kinetics[8]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/GEF* /kinetics/chain/kinetics[8]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/GEF* /kinetics/chain/kinetics[8]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ras-act-craf /kinetics/chain/kinetics[8]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[8]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[8]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[8]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[8]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[8]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[8]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[8]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[8]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[8]/Ras-act-unphosph-raf /kinetics/chain/kinetics[8]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[8]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[8]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[8]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[8]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[8]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[8]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[8]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[8]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[8]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[8]/Ras/GTP-Ras /kinetics/chain/kinetics[8]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/GDP-Ras /kinetics/chain/kinetics[8]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ras/GAP* /kinetics/chain/kinetics[8]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/GAP /kinetics/chain/kinetics[8]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[8]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[8]/Ras/dephosph-GAP /kinetics/chain/kinetics[8]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/GAP*/diff /kinetics/chain/kinetics[8]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[8]/Ras/GAP*/diff /kinetics/chain/kinetics[8]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/GAP* /kinetics/chain/kinetics[8]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/GAP* /kinetics/chain/kinetics[8]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[8]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[8]/Ras/dephosph-GAP /kinetics/chain/kinetics[8]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[8]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[8]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[7]/Ras/GAP/diff /kinetics/chain/kinetics[8]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[8]/Ras/GAP/diff /kinetics/chain/kinetics[8]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/GTP-Ras /kinetics/chain/kinetics[8]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/GAP /kinetics/chain/kinetics[8]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[8]/Ras/GAP /kinetics/chain/kinetics[8]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/GAP /kinetics/chain/kinetics[8]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF /kinetics/chain/kinetics[8]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/CaM-GEF /kinetics/chain/kinetics[8]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca4 /kinetics/chain/kinetics[8]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[8]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[8]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[8]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[7]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[8]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[8]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[8]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/GDP-Ras /kinetics/chain/kinetics[8]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/CaM-GEF /kinetics/chain/kinetics[8]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[8]/Ras/CaM-GEF /kinetics/chain/kinetics[8]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/CaM-GEF /kinetics/chain/kinetics[8]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[8]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM/diff /kinetics/chain/kinetics[8]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[8]/CaM/CaM/diff /kinetics/chain/kinetics[8]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM /kinetics/chain/kinetics[8]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM /kinetics/chain/kinetics[8]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca3 /kinetics/chain/kinetics[8]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca4 /kinetics/chain/kinetics[8]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[8]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[8]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca3 /kinetics/chain/kinetics[8]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca3 /kinetics/chain/kinetics[8]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[8]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[8]/PKM/trigger_PKM /kinetics/chain/kinetics[8]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[8]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[8]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca4 /kinetics/chain/kinetics[8]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca4 /kinetics/chain/kinetics[8]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/CaM/CaM /kinetics/chain/kinetics[8]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca /kinetics/chain/kinetics[8]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ca /kinetics/chain/kinetics[8]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[8]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[8]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca2 /kinetics/chain/kinetics[8]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca2 /kinetics/chain/kinetics[8]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca3 /kinetics/chain/kinetics[8]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca2 /kinetics/chain/kinetics[8]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca2 /kinetics/chain/kinetics[8]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[8]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[8]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[8]/Ca REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[8]/Ca REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[8]/Ca REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[8]/Ca REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[8]/Ca REAC A B addmsg /kinetics/chain/kinetics[8]/Ca_diff /kinetics/chain/kinetics[8]/Ca REAC B A addmsg /kinetics/chain/kinetics[7]/Ca/diff /kinetics/chain/kinetics[8]/Ca REAC B A addmsg /kinetics/chain/kinetics[8]/Ca/diff /kinetics/chain/kinetics[8]/Ca REAC A B addmsg /kinetics/chain/kinetics[8]/Ca /kinetics/chain/kinetics[8]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ca /kinetics/chain/kinetics[8]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1 /kinetics/chain/kinetics[8]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[8]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ras/GTP-Ras /kinetics/chain/kinetics[8]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKM/trigger_PKM /kinetics/chain/kinetics[8]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[7]/PKM/Ca_detector/diff /kinetics/chain/kinetics[8]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[8]/PKM/Ca_detector/diff /kinetics/chain/kinetics[8]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[8]/PKM/Ca_detector /kinetics/chain/kinetics[8]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKM/Ca_detector /kinetics/chain/kinetics[8]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[8]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[8]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[8]/PKM/turn_off_activator /kinetics/chain/kinetics[8]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[7]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[8]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[8]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[8]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[8]/PKM/PKM_synthesis /kinetics/chain/kinetics[8]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[8]/PKM/AA_pool /kinetics/chain/kinetics[8]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKM/PKM_synthesis /kinetics/chain/kinetics[8]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKM/PKM_synthesis /kinetics/chain/kinetics[8]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[8]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[8]/PKC/PKM-zeta /kinetics/chain/kinetics[8]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKM/degraded_PKM /kinetics/chain/kinetics[8]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKM/PKM_degradation /kinetics/chain/kinetics[8]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[8]/PKM/trigger_PKM /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[8]/PKM/PKM_activator /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[8]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[8]/PKM/turn_off_activator /kinetics/chain/kinetics[8]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[7]/PKM/PKM_activator/diff /kinetics/chain/kinetics[8]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[8]/PKM/PKM_activator/diff /kinetics/chain/kinetics[8]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[8]/PKM/PKM_activator /kinetics/chain/kinetics[8]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKM/PKM_activator /kinetics/chain/kinetics[8]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKM/PKM_synthesis /kinetics/chain/kinetics[8]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKM/PKM_activator /kinetics/chain/kinetics[8]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca4 /kinetics/chain/kinetics[8]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKM/Ca_detector /kinetics/chain/kinetics[8]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex /kinetics/chain/kinetics[8]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ca_diff /kinetics/chain/kinetics[8]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[8]/Ca /kinetics/chain/kinetics[8]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ca_input /kinetics/chain/kinetics[8]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[9]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[9]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[9]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[9]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[9]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca /kinetics/chain/kinetics[9]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca /kinetics/chain/kinetics[9]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ca /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca /kinetics/chain/kinetics[9]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[9]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[9]/DAG /kinetics/chain/kinetics[9]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca /kinetics/chain/kinetics[9]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[9]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[9]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[9]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/DAG /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG /kinetics/chain/kinetics[9]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[9]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[9]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG /kinetics/chain/kinetics[9]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG /kinetics/chain/kinetics[9]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[9]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[9]/PKM/PKM_degradation /kinetics/chain/kinetics[9]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[9]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[9]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKM-zeta /kinetics/chain/kinetics[9]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKM-zeta /kinetics/chain/kinetics[9]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[9]/DAG REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG /kinetics/chain/kinetics[9]/DAG REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[9]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[9]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[9]/PKC/PKM-zeta /kinetics/chain/kinetics[9]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[9]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[9]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[9]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[9]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[9]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[9]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[9]/PKC-active /kinetics/chain/kinetics[9]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1 /kinetics/chain/kinetics[9]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC-active /kinetics/chain/kinetics[9]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[9]/Ras/GAP /kinetics/chain/kinetics[9]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC-active /kinetics/chain/kinetics[9]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF /kinetics/chain/kinetics[9]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[9]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[9]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[9]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[8]/MAPK*/diff /kinetics/chain/kinetics[9]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[9]/MAPK*/diff /kinetics/chain/kinetics[9]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[9]/MAPK* /kinetics/chain/kinetics[9]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1* /kinetics/chain/kinetics[9]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK* /kinetics/chain/kinetics[9]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK* /kinetics/chain/kinetics[9]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[9]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[9]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[9]/Ras-act-unphosph-raf /kinetics/chain/kinetics[9]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[9]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[9]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[9]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[9]/Ras-act-craf /kinetics/chain/kinetics[9]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[9]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[9]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[9]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[9]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[9]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[9]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[9]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[9]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK/diff /kinetics/chain/kinetics[9]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK/diff /kinetics/chain/kinetics[9]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK /kinetics/chain/kinetics[9]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK /kinetics/chain/kinetics[9]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[9]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[9]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[9]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[9]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[9]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[9]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[9]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[9]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[9]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK* /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK* /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[9]/Ras-act-unphosph-raf /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[9]/Ras-act-craf /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[9]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[9]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[9]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[9]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[8]/MKP-1/diff /kinetics/chain/kinetics[9]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[9]/MKP-1/diff /kinetics/chain/kinetics[9]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr /kinetics/chain/kinetics[9]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MKP-1 /kinetics/chain/kinetics[9]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK* /kinetics/chain/kinetics[9]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MKP-1 /kinetics/chain/kinetics[9]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[9]/MKP-1 /kinetics/chain/kinetics[9]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MKP-1 /kinetics/chain/kinetics[9]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1* /kinetics/chain/kinetics[9]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[9]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ras/GTP-Ras /kinetics/chain/kinetics[9]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[9]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[9]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[9]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[9]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/diff /kinetics/chain/kinetics[9]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/diff /kinetics/chain/kinetics[9]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1* /kinetics/chain/kinetics[9]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A /kinetics/chain/kinetics[9]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK* /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1** /kinetics/chain/kinetics[9]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A /kinetics/chain/kinetics[9]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A /kinetics/chain/kinetics[9]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A /kinetics/chain/kinetics[9]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF /kinetics/chain/kinetics[9]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ras/GEF* /kinetics/chain/kinetics[9]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[9]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[9]/Ras/dephosph-GEF /kinetics/chain/kinetics[9]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[9]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[9]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[9]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF/diff /kinetics/chain/kinetics[9]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF/diff /kinetics/chain/kinetics[9]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF /kinetics/chain/kinetics[9]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[9]/Ras/GDP-Ras /kinetics/chain/kinetics[9]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF /kinetics/chain/kinetics[9]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF /kinetics/chain/kinetics[9]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[9]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[9]/Ras/dephosph-GEF /kinetics/chain/kinetics[9]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[9]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[8]/Ras/GEF*/diff /kinetics/chain/kinetics[9]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[9]/Ras/GEF*/diff /kinetics/chain/kinetics[9]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/GEF* /kinetics/chain/kinetics[9]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[9]/Ras/GDP-Ras /kinetics/chain/kinetics[9]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/GEF* /kinetics/chain/kinetics[9]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/GEF* /kinetics/chain/kinetics[9]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ras-act-craf /kinetics/chain/kinetics[9]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[9]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[9]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[9]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[9]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[9]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[9]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[9]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[9]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[9]/Ras-act-unphosph-raf /kinetics/chain/kinetics[9]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[9]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[9]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[9]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[9]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[9]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[9]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[9]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[9]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[9]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[9]/Ras/GTP-Ras /kinetics/chain/kinetics[9]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/GDP-Ras /kinetics/chain/kinetics[9]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ras/GAP* /kinetics/chain/kinetics[9]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/GAP /kinetics/chain/kinetics[9]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[9]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[9]/Ras/dephosph-GAP /kinetics/chain/kinetics[9]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/GAP*/diff /kinetics/chain/kinetics[9]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[9]/Ras/GAP*/diff /kinetics/chain/kinetics[9]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/GAP* /kinetics/chain/kinetics[9]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/GAP* /kinetics/chain/kinetics[9]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[9]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[9]/Ras/dephosph-GAP /kinetics/chain/kinetics[9]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[9]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[9]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[8]/Ras/GAP/diff /kinetics/chain/kinetics[9]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[9]/Ras/GAP/diff /kinetics/chain/kinetics[9]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/GTP-Ras /kinetics/chain/kinetics[9]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/GAP /kinetics/chain/kinetics[9]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[9]/Ras/GAP /kinetics/chain/kinetics[9]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/GAP /kinetics/chain/kinetics[9]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF /kinetics/chain/kinetics[9]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/CaM-GEF /kinetics/chain/kinetics[9]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca4 /kinetics/chain/kinetics[9]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[9]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[9]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[9]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[8]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[9]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[9]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[9]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/GDP-Ras /kinetics/chain/kinetics[9]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/CaM-GEF /kinetics/chain/kinetics[9]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[9]/Ras/CaM-GEF /kinetics/chain/kinetics[9]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/CaM-GEF /kinetics/chain/kinetics[9]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[9]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM/diff /kinetics/chain/kinetics[9]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[9]/CaM/CaM/diff /kinetics/chain/kinetics[9]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM /kinetics/chain/kinetics[9]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM /kinetics/chain/kinetics[9]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca3 /kinetics/chain/kinetics[9]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca4 /kinetics/chain/kinetics[9]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[9]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[9]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca3 /kinetics/chain/kinetics[9]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca3 /kinetics/chain/kinetics[9]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[9]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[9]/PKM/trigger_PKM /kinetics/chain/kinetics[9]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[9]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[9]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca4 /kinetics/chain/kinetics[9]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca4 /kinetics/chain/kinetics[9]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/CaM/CaM /kinetics/chain/kinetics[9]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca /kinetics/chain/kinetics[9]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ca /kinetics/chain/kinetics[9]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[9]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[9]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca2 /kinetics/chain/kinetics[9]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca2 /kinetics/chain/kinetics[9]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca3 /kinetics/chain/kinetics[9]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca2 /kinetics/chain/kinetics[9]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca2 /kinetics/chain/kinetics[9]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[9]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[9]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[9]/Ca REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[9]/Ca REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[9]/Ca REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[9]/Ca REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[9]/Ca REAC A B addmsg /kinetics/chain/kinetics[9]/Ca_diff /kinetics/chain/kinetics[9]/Ca REAC B A addmsg /kinetics/chain/kinetics[8]/Ca/diff /kinetics/chain/kinetics[9]/Ca REAC B A addmsg /kinetics/chain/kinetics[9]/Ca/diff /kinetics/chain/kinetics[9]/Ca REAC A B addmsg /kinetics/chain/kinetics[9]/Ca /kinetics/chain/kinetics[9]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ca /kinetics/chain/kinetics[9]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1 /kinetics/chain/kinetics[9]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[9]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ras/GTP-Ras /kinetics/chain/kinetics[9]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKM/trigger_PKM /kinetics/chain/kinetics[9]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[8]/PKM/Ca_detector/diff /kinetics/chain/kinetics[9]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[9]/PKM/Ca_detector/diff /kinetics/chain/kinetics[9]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[9]/PKM/Ca_detector /kinetics/chain/kinetics[9]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKM/Ca_detector /kinetics/chain/kinetics[9]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[9]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[9]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[9]/PKM/turn_off_activator /kinetics/chain/kinetics[9]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[8]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[9]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[9]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[9]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[9]/PKM/PKM_synthesis /kinetics/chain/kinetics[9]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[9]/PKM/AA_pool /kinetics/chain/kinetics[9]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKM/PKM_synthesis /kinetics/chain/kinetics[9]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKM/PKM_synthesis /kinetics/chain/kinetics[9]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[9]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[9]/PKC/PKM-zeta /kinetics/chain/kinetics[9]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKM/degraded_PKM /kinetics/chain/kinetics[9]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKM/PKM_degradation /kinetics/chain/kinetics[9]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[9]/PKM/trigger_PKM /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[9]/PKM/PKM_activator /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[9]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[9]/PKM/turn_off_activator /kinetics/chain/kinetics[9]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[8]/PKM/PKM_activator/diff /kinetics/chain/kinetics[9]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[9]/PKM/PKM_activator/diff /kinetics/chain/kinetics[9]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[9]/PKM/PKM_activator /kinetics/chain/kinetics[9]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKM/PKM_activator /kinetics/chain/kinetics[9]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKM/PKM_synthesis /kinetics/chain/kinetics[9]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKM/PKM_activator /kinetics/chain/kinetics[9]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca4 /kinetics/chain/kinetics[9]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKM/Ca_detector /kinetics/chain/kinetics[9]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex /kinetics/chain/kinetics[9]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ca_diff /kinetics/chain/kinetics[9]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[9]/Ca /kinetics/chain/kinetics[9]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ca_input /kinetics/chain/kinetics[9]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[10]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[10]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[10]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[10]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[10]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca /kinetics/chain/kinetics[10]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca /kinetics/chain/kinetics[10]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ca /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca /kinetics/chain/kinetics[10]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[10]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[10]/DAG /kinetics/chain/kinetics[10]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca /kinetics/chain/kinetics[10]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[10]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[10]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[10]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/DAG /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG /kinetics/chain/kinetics[10]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[10]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[10]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG /kinetics/chain/kinetics[10]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG /kinetics/chain/kinetics[10]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[10]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[10]/PKM/PKM_degradation /kinetics/chain/kinetics[10]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[10]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[10]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKM-zeta /kinetics/chain/kinetics[10]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKM-zeta /kinetics/chain/kinetics[10]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[10]/DAG REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG /kinetics/chain/kinetics[10]/DAG REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[10]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[10]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[10]/PKC/PKM-zeta /kinetics/chain/kinetics[10]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[10]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[10]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[10]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[10]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[10]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[10]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[10]/PKC-active /kinetics/chain/kinetics[10]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1 /kinetics/chain/kinetics[10]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC-active /kinetics/chain/kinetics[10]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[10]/Ras/GAP /kinetics/chain/kinetics[10]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC-active /kinetics/chain/kinetics[10]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF /kinetics/chain/kinetics[10]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[10]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[10]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[10]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[9]/MAPK*/diff /kinetics/chain/kinetics[10]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[10]/MAPK*/diff /kinetics/chain/kinetics[10]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[10]/MAPK* /kinetics/chain/kinetics[10]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1* /kinetics/chain/kinetics[10]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK* /kinetics/chain/kinetics[10]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK* /kinetics/chain/kinetics[10]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[10]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[10]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[10]/Ras-act-unphosph-raf /kinetics/chain/kinetics[10]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[10]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[10]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[10]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[10]/Ras-act-craf /kinetics/chain/kinetics[10]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[10]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[10]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[10]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[10]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[10]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[10]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[10]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[10]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK/diff /kinetics/chain/kinetics[10]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK/diff /kinetics/chain/kinetics[10]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK /kinetics/chain/kinetics[10]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK /kinetics/chain/kinetics[10]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[10]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[10]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[10]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[10]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[10]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[10]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[10]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[10]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[10]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK* /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK* /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[10]/Ras-act-unphosph-raf /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[10]/Ras-act-craf /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[10]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[10]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[10]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[10]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[9]/MKP-1/diff /kinetics/chain/kinetics[10]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[10]/MKP-1/diff /kinetics/chain/kinetics[10]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr /kinetics/chain/kinetics[10]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MKP-1 /kinetics/chain/kinetics[10]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK* /kinetics/chain/kinetics[10]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MKP-1 /kinetics/chain/kinetics[10]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[10]/MKP-1 /kinetics/chain/kinetics[10]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MKP-1 /kinetics/chain/kinetics[10]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1* /kinetics/chain/kinetics[10]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[10]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ras/GTP-Ras /kinetics/chain/kinetics[10]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[10]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[10]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[10]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[10]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/diff /kinetics/chain/kinetics[10]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/diff /kinetics/chain/kinetics[10]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1* /kinetics/chain/kinetics[10]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A /kinetics/chain/kinetics[10]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK* /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1** /kinetics/chain/kinetics[10]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A /kinetics/chain/kinetics[10]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A /kinetics/chain/kinetics[10]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A /kinetics/chain/kinetics[10]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF /kinetics/chain/kinetics[10]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ras/GEF* /kinetics/chain/kinetics[10]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[10]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[10]/Ras/dephosph-GEF /kinetics/chain/kinetics[10]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[10]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[10]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[10]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF/diff /kinetics/chain/kinetics[10]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF/diff /kinetics/chain/kinetics[10]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF /kinetics/chain/kinetics[10]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[10]/Ras/GDP-Ras /kinetics/chain/kinetics[10]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF /kinetics/chain/kinetics[10]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF /kinetics/chain/kinetics[10]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[10]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[10]/Ras/dephosph-GEF /kinetics/chain/kinetics[10]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[10]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[9]/Ras/GEF*/diff /kinetics/chain/kinetics[10]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[10]/Ras/GEF*/diff /kinetics/chain/kinetics[10]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/GEF* /kinetics/chain/kinetics[10]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[10]/Ras/GDP-Ras /kinetics/chain/kinetics[10]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/GEF* /kinetics/chain/kinetics[10]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/GEF* /kinetics/chain/kinetics[10]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ras-act-craf /kinetics/chain/kinetics[10]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[10]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[10]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[10]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[10]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[10]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[10]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[10]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[10]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[10]/Ras-act-unphosph-raf /kinetics/chain/kinetics[10]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[10]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[10]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[10]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[10]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[10]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[10]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[10]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[10]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[10]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[10]/Ras/GTP-Ras /kinetics/chain/kinetics[10]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/GDP-Ras /kinetics/chain/kinetics[10]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ras/GAP* /kinetics/chain/kinetics[10]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/GAP /kinetics/chain/kinetics[10]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[10]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[10]/Ras/dephosph-GAP /kinetics/chain/kinetics[10]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/GAP*/diff /kinetics/chain/kinetics[10]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[10]/Ras/GAP*/diff /kinetics/chain/kinetics[10]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/GAP* /kinetics/chain/kinetics[10]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/GAP* /kinetics/chain/kinetics[10]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[10]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[10]/Ras/dephosph-GAP /kinetics/chain/kinetics[10]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[10]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[10]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[9]/Ras/GAP/diff /kinetics/chain/kinetics[10]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[10]/Ras/GAP/diff /kinetics/chain/kinetics[10]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/GTP-Ras /kinetics/chain/kinetics[10]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/GAP /kinetics/chain/kinetics[10]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[10]/Ras/GAP /kinetics/chain/kinetics[10]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/GAP /kinetics/chain/kinetics[10]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF /kinetics/chain/kinetics[10]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/CaM-GEF /kinetics/chain/kinetics[10]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca4 /kinetics/chain/kinetics[10]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[10]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[10]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[10]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[9]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[10]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[10]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[10]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/GDP-Ras /kinetics/chain/kinetics[10]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/CaM-GEF /kinetics/chain/kinetics[10]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[10]/Ras/CaM-GEF /kinetics/chain/kinetics[10]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/CaM-GEF /kinetics/chain/kinetics[10]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[10]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM/diff /kinetics/chain/kinetics[10]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[10]/CaM/CaM/diff /kinetics/chain/kinetics[10]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM /kinetics/chain/kinetics[10]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM /kinetics/chain/kinetics[10]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca3 /kinetics/chain/kinetics[10]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca4 /kinetics/chain/kinetics[10]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[10]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[10]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca3 /kinetics/chain/kinetics[10]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca3 /kinetics/chain/kinetics[10]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[10]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[10]/PKM/trigger_PKM /kinetics/chain/kinetics[10]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[10]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[10]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca4 /kinetics/chain/kinetics[10]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca4 /kinetics/chain/kinetics[10]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/CaM/CaM /kinetics/chain/kinetics[10]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca /kinetics/chain/kinetics[10]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ca /kinetics/chain/kinetics[10]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[10]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[10]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca2 /kinetics/chain/kinetics[10]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca2 /kinetics/chain/kinetics[10]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca3 /kinetics/chain/kinetics[10]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca2 /kinetics/chain/kinetics[10]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca2 /kinetics/chain/kinetics[10]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[10]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[10]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[10]/Ca REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[10]/Ca REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[10]/Ca REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[10]/Ca REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[10]/Ca REAC A B addmsg /kinetics/chain/kinetics[10]/Ca_diff /kinetics/chain/kinetics[10]/Ca REAC B A addmsg /kinetics/chain/kinetics[9]/Ca/diff /kinetics/chain/kinetics[10]/Ca REAC B A addmsg /kinetics/chain/kinetics[10]/Ca/diff /kinetics/chain/kinetics[10]/Ca REAC A B addmsg /kinetics/chain/kinetics[10]/Ca /kinetics/chain/kinetics[10]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ca /kinetics/chain/kinetics[10]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1 /kinetics/chain/kinetics[10]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[10]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ras/GTP-Ras /kinetics/chain/kinetics[10]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKM/trigger_PKM /kinetics/chain/kinetics[10]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[9]/PKM/Ca_detector/diff /kinetics/chain/kinetics[10]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[10]/PKM/Ca_detector/diff /kinetics/chain/kinetics[10]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[10]/PKM/Ca_detector /kinetics/chain/kinetics[10]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKM/Ca_detector /kinetics/chain/kinetics[10]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[10]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[10]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[10]/PKM/turn_off_activator /kinetics/chain/kinetics[10]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[9]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[10]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[10]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[10]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[10]/PKM/PKM_synthesis /kinetics/chain/kinetics[10]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[10]/PKM/AA_pool /kinetics/chain/kinetics[10]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKM/PKM_synthesis /kinetics/chain/kinetics[10]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKM/PKM_synthesis /kinetics/chain/kinetics[10]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[10]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[10]/PKC/PKM-zeta /kinetics/chain/kinetics[10]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKM/degraded_PKM /kinetics/chain/kinetics[10]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKM/PKM_degradation /kinetics/chain/kinetics[10]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[10]/PKM/trigger_PKM /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[10]/PKM/PKM_activator /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[10]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[10]/PKM/turn_off_activator /kinetics/chain/kinetics[10]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[9]/PKM/PKM_activator/diff /kinetics/chain/kinetics[10]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[10]/PKM/PKM_activator/diff /kinetics/chain/kinetics[10]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[10]/PKM/PKM_activator /kinetics/chain/kinetics[10]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKM/PKM_activator /kinetics/chain/kinetics[10]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKM/PKM_synthesis /kinetics/chain/kinetics[10]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKM/PKM_activator /kinetics/chain/kinetics[10]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca4 /kinetics/chain/kinetics[10]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKM/Ca_detector /kinetics/chain/kinetics[10]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex /kinetics/chain/kinetics[10]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ca_diff /kinetics/chain/kinetics[10]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[10]/Ca /kinetics/chain/kinetics[10]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ca_input /kinetics/chain/kinetics[10]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[11]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[11]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[11]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[11]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[11]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca /kinetics/chain/kinetics[11]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca /kinetics/chain/kinetics[11]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ca /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca /kinetics/chain/kinetics[11]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[11]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[11]/DAG /kinetics/chain/kinetics[11]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca /kinetics/chain/kinetics[11]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[11]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[11]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[11]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/DAG /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG /kinetics/chain/kinetics[11]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[11]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[11]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG /kinetics/chain/kinetics[11]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG /kinetics/chain/kinetics[11]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[11]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[11]/PKM/PKM_degradation /kinetics/chain/kinetics[11]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[11]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[11]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKM-zeta /kinetics/chain/kinetics[11]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKM-zeta /kinetics/chain/kinetics[11]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[11]/DAG REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG /kinetics/chain/kinetics[11]/DAG REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[11]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[11]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[11]/PKC/PKM-zeta /kinetics/chain/kinetics[11]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[11]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[11]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[11]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[11]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[11]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[11]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[11]/PKC-active /kinetics/chain/kinetics[11]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1 /kinetics/chain/kinetics[11]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC-active /kinetics/chain/kinetics[11]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[11]/Ras/GAP /kinetics/chain/kinetics[11]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC-active /kinetics/chain/kinetics[11]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF /kinetics/chain/kinetics[11]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[11]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[11]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[11]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[10]/MAPK*/diff /kinetics/chain/kinetics[11]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[11]/MAPK*/diff /kinetics/chain/kinetics[11]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[11]/MAPK* /kinetics/chain/kinetics[11]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1* /kinetics/chain/kinetics[11]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK* /kinetics/chain/kinetics[11]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK* /kinetics/chain/kinetics[11]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[11]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[11]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[11]/Ras-act-unphosph-raf /kinetics/chain/kinetics[11]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[11]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[11]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[11]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[11]/Ras-act-craf /kinetics/chain/kinetics[11]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[11]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[11]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[11]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[11]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[11]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[11]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[11]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[11]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK/diff /kinetics/chain/kinetics[11]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK/diff /kinetics/chain/kinetics[11]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK /kinetics/chain/kinetics[11]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK /kinetics/chain/kinetics[11]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[11]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[11]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[11]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[11]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[11]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[11]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[11]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[11]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[11]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK* /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK* /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[11]/Ras-act-unphosph-raf /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[11]/Ras-act-craf /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[11]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[11]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[11]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[11]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[10]/MKP-1/diff /kinetics/chain/kinetics[11]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[11]/MKP-1/diff /kinetics/chain/kinetics[11]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr /kinetics/chain/kinetics[11]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MKP-1 /kinetics/chain/kinetics[11]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK* /kinetics/chain/kinetics[11]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MKP-1 /kinetics/chain/kinetics[11]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[11]/MKP-1 /kinetics/chain/kinetics[11]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MKP-1 /kinetics/chain/kinetics[11]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1* /kinetics/chain/kinetics[11]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[11]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ras/GTP-Ras /kinetics/chain/kinetics[11]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[11]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[11]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[11]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[11]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/diff /kinetics/chain/kinetics[11]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/diff /kinetics/chain/kinetics[11]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1* /kinetics/chain/kinetics[11]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A /kinetics/chain/kinetics[11]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK* /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1** /kinetics/chain/kinetics[11]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A /kinetics/chain/kinetics[11]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A /kinetics/chain/kinetics[11]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A /kinetics/chain/kinetics[11]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF /kinetics/chain/kinetics[11]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ras/GEF* /kinetics/chain/kinetics[11]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[11]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[11]/Ras/dephosph-GEF /kinetics/chain/kinetics[11]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[11]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[11]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[11]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF/diff /kinetics/chain/kinetics[11]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF/diff /kinetics/chain/kinetics[11]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF /kinetics/chain/kinetics[11]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[11]/Ras/GDP-Ras /kinetics/chain/kinetics[11]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF /kinetics/chain/kinetics[11]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF /kinetics/chain/kinetics[11]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[11]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[11]/Ras/dephosph-GEF /kinetics/chain/kinetics[11]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[11]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[10]/Ras/GEF*/diff /kinetics/chain/kinetics[11]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[11]/Ras/GEF*/diff /kinetics/chain/kinetics[11]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/GEF* /kinetics/chain/kinetics[11]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[11]/Ras/GDP-Ras /kinetics/chain/kinetics[11]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/GEF* /kinetics/chain/kinetics[11]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/GEF* /kinetics/chain/kinetics[11]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ras-act-craf /kinetics/chain/kinetics[11]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[11]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[11]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[11]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[11]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[11]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[11]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[11]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[11]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[11]/Ras-act-unphosph-raf /kinetics/chain/kinetics[11]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[11]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[11]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[11]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[11]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[11]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[11]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[11]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[11]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[11]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[11]/Ras/GTP-Ras /kinetics/chain/kinetics[11]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/GDP-Ras /kinetics/chain/kinetics[11]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ras/GAP* /kinetics/chain/kinetics[11]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/GAP /kinetics/chain/kinetics[11]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[11]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[11]/Ras/dephosph-GAP /kinetics/chain/kinetics[11]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/GAP*/diff /kinetics/chain/kinetics[11]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[11]/Ras/GAP*/diff /kinetics/chain/kinetics[11]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/GAP* /kinetics/chain/kinetics[11]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/GAP* /kinetics/chain/kinetics[11]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[11]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[11]/Ras/dephosph-GAP /kinetics/chain/kinetics[11]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[11]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[11]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[10]/Ras/GAP/diff /kinetics/chain/kinetics[11]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[11]/Ras/GAP/diff /kinetics/chain/kinetics[11]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/GTP-Ras /kinetics/chain/kinetics[11]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/GAP /kinetics/chain/kinetics[11]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[11]/Ras/GAP /kinetics/chain/kinetics[11]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/GAP /kinetics/chain/kinetics[11]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF /kinetics/chain/kinetics[11]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/CaM-GEF /kinetics/chain/kinetics[11]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca4 /kinetics/chain/kinetics[11]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[11]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[11]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[11]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[10]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[11]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[11]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[11]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/GDP-Ras /kinetics/chain/kinetics[11]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/CaM-GEF /kinetics/chain/kinetics[11]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[11]/Ras/CaM-GEF /kinetics/chain/kinetics[11]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/CaM-GEF /kinetics/chain/kinetics[11]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[11]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM/diff /kinetics/chain/kinetics[11]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[11]/CaM/CaM/diff /kinetics/chain/kinetics[11]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM /kinetics/chain/kinetics[11]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM /kinetics/chain/kinetics[11]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca3 /kinetics/chain/kinetics[11]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca4 /kinetics/chain/kinetics[11]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[11]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[11]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca3 /kinetics/chain/kinetics[11]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca3 /kinetics/chain/kinetics[11]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[11]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[11]/PKM/trigger_PKM /kinetics/chain/kinetics[11]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[11]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[11]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca4 /kinetics/chain/kinetics[11]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 /kinetics/chain/kinetics[11]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/CaM/CaM /kinetics/chain/kinetics[11]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca /kinetics/chain/kinetics[11]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ca /kinetics/chain/kinetics[11]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[11]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[11]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca2 /kinetics/chain/kinetics[11]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca2 /kinetics/chain/kinetics[11]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca3 /kinetics/chain/kinetics[11]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca2 /kinetics/chain/kinetics[11]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca2 /kinetics/chain/kinetics[11]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[11]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[11]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[11]/Ca REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[11]/Ca REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[11]/Ca REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[11]/Ca REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[11]/Ca REAC A B addmsg /kinetics/chain/kinetics[11]/Ca_diff /kinetics/chain/kinetics[11]/Ca REAC B A addmsg /kinetics/chain/kinetics[10]/Ca/diff /kinetics/chain/kinetics[11]/Ca REAC B A addmsg /kinetics/chain/kinetics[11]/Ca/diff /kinetics/chain/kinetics[11]/Ca REAC A B addmsg /kinetics/chain/kinetics[11]/Ca /kinetics/chain/kinetics[11]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ca /kinetics/chain/kinetics[11]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1 /kinetics/chain/kinetics[11]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[11]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ras/GTP-Ras /kinetics/chain/kinetics[11]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKM/trigger_PKM /kinetics/chain/kinetics[11]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[10]/PKM/Ca_detector/diff /kinetics/chain/kinetics[11]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[11]/PKM/Ca_detector/diff /kinetics/chain/kinetics[11]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[11]/PKM/Ca_detector /kinetics/chain/kinetics[11]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKM/Ca_detector /kinetics/chain/kinetics[11]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[11]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[11]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[11]/PKM/turn_off_activator /kinetics/chain/kinetics[11]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[10]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[11]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[11]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[11]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[11]/PKM/PKM_synthesis /kinetics/chain/kinetics[11]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[11]/PKM/AA_pool /kinetics/chain/kinetics[11]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKM/PKM_synthesis /kinetics/chain/kinetics[11]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKM/PKM_synthesis /kinetics/chain/kinetics[11]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[11]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[11]/PKC/PKM-zeta /kinetics/chain/kinetics[11]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKM/degraded_PKM /kinetics/chain/kinetics[11]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKM/PKM_degradation /kinetics/chain/kinetics[11]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[11]/PKM/trigger_PKM /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[11]/PKM/PKM_activator /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[11]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[11]/PKM/turn_off_activator /kinetics/chain/kinetics[11]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[10]/PKM/PKM_activator/diff /kinetics/chain/kinetics[11]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[11]/PKM/PKM_activator/diff /kinetics/chain/kinetics[11]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[11]/PKM/PKM_activator /kinetics/chain/kinetics[11]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKM/PKM_activator /kinetics/chain/kinetics[11]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKM/PKM_synthesis /kinetics/chain/kinetics[11]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKM/PKM_activator /kinetics/chain/kinetics[11]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca4 /kinetics/chain/kinetics[11]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKM/Ca_detector /kinetics/chain/kinetics[11]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex /kinetics/chain/kinetics[11]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ca_diff /kinetics/chain/kinetics[11]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[11]/Ca /kinetics/chain/kinetics[11]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ca_input /kinetics/chain/kinetics[11]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[12]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[12]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[12]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[12]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[12]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca /kinetics/chain/kinetics[12]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca /kinetics/chain/kinetics[12]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ca /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca /kinetics/chain/kinetics[12]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[12]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[12]/DAG /kinetics/chain/kinetics[12]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca /kinetics/chain/kinetics[12]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[12]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[12]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[12]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/DAG /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG /kinetics/chain/kinetics[12]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[12]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[12]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG /kinetics/chain/kinetics[12]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG /kinetics/chain/kinetics[12]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[12]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[12]/PKM/PKM_degradation /kinetics/chain/kinetics[12]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[12]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[12]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKM-zeta /kinetics/chain/kinetics[12]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKM-zeta /kinetics/chain/kinetics[12]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[12]/DAG REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG /kinetics/chain/kinetics[12]/DAG REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[12]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[12]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[12]/PKC/PKM-zeta /kinetics/chain/kinetics[12]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[12]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[12]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[12]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[12]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[12]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[12]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[12]/PKC-active /kinetics/chain/kinetics[12]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1 /kinetics/chain/kinetics[12]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC-active /kinetics/chain/kinetics[12]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[12]/Ras/GAP /kinetics/chain/kinetics[12]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC-active /kinetics/chain/kinetics[12]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF /kinetics/chain/kinetics[12]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[12]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[12]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[12]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[11]/MAPK*/diff /kinetics/chain/kinetics[12]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[12]/MAPK*/diff /kinetics/chain/kinetics[12]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[12]/MAPK* /kinetics/chain/kinetics[12]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1* /kinetics/chain/kinetics[12]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK* /kinetics/chain/kinetics[12]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK* /kinetics/chain/kinetics[12]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[12]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[12]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[12]/Ras-act-unphosph-raf /kinetics/chain/kinetics[12]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[12]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[12]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[12]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[12]/Ras-act-craf /kinetics/chain/kinetics[12]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[12]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[12]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[12]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[12]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[12]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[12]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[12]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[12]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK/diff /kinetics/chain/kinetics[12]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK/diff /kinetics/chain/kinetics[12]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK /kinetics/chain/kinetics[12]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK /kinetics/chain/kinetics[12]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[12]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[12]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[12]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[12]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[12]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[12]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[12]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[12]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[12]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK* /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK* /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[12]/Ras-act-unphosph-raf /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[12]/Ras-act-craf /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[12]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[12]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[12]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[12]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[11]/MKP-1/diff /kinetics/chain/kinetics[12]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[12]/MKP-1/diff /kinetics/chain/kinetics[12]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr /kinetics/chain/kinetics[12]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MKP-1 /kinetics/chain/kinetics[12]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK* /kinetics/chain/kinetics[12]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MKP-1 /kinetics/chain/kinetics[12]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[12]/MKP-1 /kinetics/chain/kinetics[12]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MKP-1 /kinetics/chain/kinetics[12]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1* /kinetics/chain/kinetics[12]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[12]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ras/GTP-Ras /kinetics/chain/kinetics[12]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[12]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[12]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[12]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[12]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/diff /kinetics/chain/kinetics[12]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/diff /kinetics/chain/kinetics[12]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1* /kinetics/chain/kinetics[12]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A /kinetics/chain/kinetics[12]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK* /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1** /kinetics/chain/kinetics[12]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A /kinetics/chain/kinetics[12]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A /kinetics/chain/kinetics[12]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A /kinetics/chain/kinetics[12]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF /kinetics/chain/kinetics[12]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ras/GEF* /kinetics/chain/kinetics[12]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[12]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[12]/Ras/dephosph-GEF /kinetics/chain/kinetics[12]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[12]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[12]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[12]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF/diff /kinetics/chain/kinetics[12]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF/diff /kinetics/chain/kinetics[12]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF /kinetics/chain/kinetics[12]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[12]/Ras/GDP-Ras /kinetics/chain/kinetics[12]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF /kinetics/chain/kinetics[12]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF /kinetics/chain/kinetics[12]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[12]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[12]/Ras/dephosph-GEF /kinetics/chain/kinetics[12]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[12]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[11]/Ras/GEF*/diff /kinetics/chain/kinetics[12]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[12]/Ras/GEF*/diff /kinetics/chain/kinetics[12]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/GEF* /kinetics/chain/kinetics[12]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[12]/Ras/GDP-Ras /kinetics/chain/kinetics[12]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/GEF* /kinetics/chain/kinetics[12]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/GEF* /kinetics/chain/kinetics[12]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ras-act-craf /kinetics/chain/kinetics[12]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[12]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[12]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[12]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[12]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[12]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[12]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[12]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[12]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[12]/Ras-act-unphosph-raf /kinetics/chain/kinetics[12]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[12]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[12]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[12]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[12]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[12]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[12]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[12]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[12]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[12]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[12]/Ras/GTP-Ras /kinetics/chain/kinetics[12]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/GDP-Ras /kinetics/chain/kinetics[12]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ras/GAP* /kinetics/chain/kinetics[12]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/GAP /kinetics/chain/kinetics[12]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[12]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[12]/Ras/dephosph-GAP /kinetics/chain/kinetics[12]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/GAP*/diff /kinetics/chain/kinetics[12]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[12]/Ras/GAP*/diff /kinetics/chain/kinetics[12]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/GAP* /kinetics/chain/kinetics[12]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/GAP* /kinetics/chain/kinetics[12]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[12]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[12]/Ras/dephosph-GAP /kinetics/chain/kinetics[12]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[12]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[12]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[11]/Ras/GAP/diff /kinetics/chain/kinetics[12]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[12]/Ras/GAP/diff /kinetics/chain/kinetics[12]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/GTP-Ras /kinetics/chain/kinetics[12]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/GAP /kinetics/chain/kinetics[12]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[12]/Ras/GAP /kinetics/chain/kinetics[12]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/GAP /kinetics/chain/kinetics[12]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF /kinetics/chain/kinetics[12]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/CaM-GEF /kinetics/chain/kinetics[12]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 /kinetics/chain/kinetics[12]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[12]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[12]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[12]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[11]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[12]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[12]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[12]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/GDP-Ras /kinetics/chain/kinetics[12]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/CaM-GEF /kinetics/chain/kinetics[12]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[12]/Ras/CaM-GEF /kinetics/chain/kinetics[12]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/CaM-GEF /kinetics/chain/kinetics[12]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[12]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM/diff /kinetics/chain/kinetics[12]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[12]/CaM/CaM/diff /kinetics/chain/kinetics[12]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM /kinetics/chain/kinetics[12]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM /kinetics/chain/kinetics[12]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca3 /kinetics/chain/kinetics[12]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 /kinetics/chain/kinetics[12]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[12]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[12]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca3 /kinetics/chain/kinetics[12]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca3 /kinetics/chain/kinetics[12]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[12]/PKM/trigger_PKM /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 /kinetics/chain/kinetics[12]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca4 /kinetics/chain/kinetics[12]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/CaM/CaM /kinetics/chain/kinetics[12]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca /kinetics/chain/kinetics[12]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ca /kinetics/chain/kinetics[12]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[12]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[12]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca2 /kinetics/chain/kinetics[12]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca2 /kinetics/chain/kinetics[12]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca3 /kinetics/chain/kinetics[12]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca2 /kinetics/chain/kinetics[12]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca2 /kinetics/chain/kinetics[12]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[12]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[12]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[12]/Ca REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[12]/Ca REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[12]/Ca REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[12]/Ca REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[12]/Ca REAC A B addmsg /kinetics/chain/kinetics[12]/Ca_diff /kinetics/chain/kinetics[12]/Ca REAC B A addmsg /kinetics/chain/kinetics[11]/Ca/diff /kinetics/chain/kinetics[12]/Ca REAC B A addmsg /kinetics/chain/kinetics[12]/Ca/diff /kinetics/chain/kinetics[12]/Ca REAC A B addmsg /kinetics/chain/kinetics[12]/Ca /kinetics/chain/kinetics[12]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ca /kinetics/chain/kinetics[12]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1 /kinetics/chain/kinetics[12]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[12]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ras/GTP-Ras /kinetics/chain/kinetics[12]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKM/trigger_PKM /kinetics/chain/kinetics[12]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[11]/PKM/Ca_detector/diff /kinetics/chain/kinetics[12]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[12]/PKM/Ca_detector/diff /kinetics/chain/kinetics[12]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[12]/PKM/Ca_detector /kinetics/chain/kinetics[12]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKM/Ca_detector /kinetics/chain/kinetics[12]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[12]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[12]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[12]/PKM/turn_off_activator /kinetics/chain/kinetics[12]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[11]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[12]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[12]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[12]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[12]/PKM/PKM_synthesis /kinetics/chain/kinetics[12]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[12]/PKM/AA_pool /kinetics/chain/kinetics[12]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKM/PKM_synthesis /kinetics/chain/kinetics[12]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKM/PKM_synthesis /kinetics/chain/kinetics[12]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[12]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[12]/PKC/PKM-zeta /kinetics/chain/kinetics[12]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKM/degraded_PKM /kinetics/chain/kinetics[12]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKM/PKM_degradation /kinetics/chain/kinetics[12]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[12]/PKM/trigger_PKM /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[12]/PKM/PKM_activator /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[12]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[12]/PKM/turn_off_activator /kinetics/chain/kinetics[12]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[11]/PKM/PKM_activator/diff /kinetics/chain/kinetics[12]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[12]/PKM/PKM_activator/diff /kinetics/chain/kinetics[12]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[12]/PKM/PKM_activator /kinetics/chain/kinetics[12]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKM/PKM_activator /kinetics/chain/kinetics[12]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKM/PKM_synthesis /kinetics/chain/kinetics[12]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKM/PKM_activator /kinetics/chain/kinetics[12]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 /kinetics/chain/kinetics[12]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKM/Ca_detector /kinetics/chain/kinetics[12]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex /kinetics/chain/kinetics[12]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ca_diff /kinetics/chain/kinetics[12]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[12]/Ca /kinetics/chain/kinetics[12]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ca_input /kinetics/chain/kinetics[12]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[13]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[13]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[13]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[13]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[13]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca /kinetics/chain/kinetics[13]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca /kinetics/chain/kinetics[13]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ca /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca /kinetics/chain/kinetics[13]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[13]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[13]/DAG /kinetics/chain/kinetics[13]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca /kinetics/chain/kinetics[13]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[13]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[13]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[13]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/DAG /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG /kinetics/chain/kinetics[13]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[13]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[13]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG /kinetics/chain/kinetics[13]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG /kinetics/chain/kinetics[13]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[13]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[13]/PKM/PKM_degradation /kinetics/chain/kinetics[13]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[13]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[13]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKM-zeta /kinetics/chain/kinetics[13]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKM-zeta /kinetics/chain/kinetics[13]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[13]/DAG REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG /kinetics/chain/kinetics[13]/DAG REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[13]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[13]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[13]/PKC/PKM-zeta /kinetics/chain/kinetics[13]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[13]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[13]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[13]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[13]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[13]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[13]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[13]/PKC-active /kinetics/chain/kinetics[13]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1 /kinetics/chain/kinetics[13]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC-active /kinetics/chain/kinetics[13]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[13]/Ras/GAP /kinetics/chain/kinetics[13]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC-active /kinetics/chain/kinetics[13]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF /kinetics/chain/kinetics[13]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[13]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[13]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[13]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[12]/MAPK*/diff /kinetics/chain/kinetics[13]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[13]/MAPK*/diff /kinetics/chain/kinetics[13]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[13]/MAPK* /kinetics/chain/kinetics[13]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1* /kinetics/chain/kinetics[13]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK* /kinetics/chain/kinetics[13]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK* /kinetics/chain/kinetics[13]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[13]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[13]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[13]/Ras-act-unphosph-raf /kinetics/chain/kinetics[13]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[13]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[13]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[13]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[13]/Ras-act-craf /kinetics/chain/kinetics[13]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[13]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[13]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[13]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[13]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[13]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[13]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[13]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[13]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK/diff /kinetics/chain/kinetics[13]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK/diff /kinetics/chain/kinetics[13]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK /kinetics/chain/kinetics[13]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK /kinetics/chain/kinetics[13]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[13]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[13]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[13]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[13]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[13]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[13]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[13]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[13]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[13]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK* /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK* /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[13]/Ras-act-unphosph-raf /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[13]/Ras-act-craf /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[13]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[13]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[13]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[13]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[12]/MKP-1/diff /kinetics/chain/kinetics[13]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[13]/MKP-1/diff /kinetics/chain/kinetics[13]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr /kinetics/chain/kinetics[13]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MKP-1 /kinetics/chain/kinetics[13]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK* /kinetics/chain/kinetics[13]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MKP-1 /kinetics/chain/kinetics[13]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[13]/MKP-1 /kinetics/chain/kinetics[13]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MKP-1 /kinetics/chain/kinetics[13]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1* /kinetics/chain/kinetics[13]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[13]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ras/GTP-Ras /kinetics/chain/kinetics[13]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[13]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[13]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[13]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[13]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/diff /kinetics/chain/kinetics[13]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/diff /kinetics/chain/kinetics[13]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1* /kinetics/chain/kinetics[13]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A /kinetics/chain/kinetics[13]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK* /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1** /kinetics/chain/kinetics[13]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A /kinetics/chain/kinetics[13]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A /kinetics/chain/kinetics[13]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A /kinetics/chain/kinetics[13]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF /kinetics/chain/kinetics[13]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ras/GEF* /kinetics/chain/kinetics[13]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[13]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[13]/Ras/dephosph-GEF /kinetics/chain/kinetics[13]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[13]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[13]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[13]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF/diff /kinetics/chain/kinetics[13]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF/diff /kinetics/chain/kinetics[13]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF /kinetics/chain/kinetics[13]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[13]/Ras/GDP-Ras /kinetics/chain/kinetics[13]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF /kinetics/chain/kinetics[13]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF /kinetics/chain/kinetics[13]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[13]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[13]/Ras/dephosph-GEF /kinetics/chain/kinetics[13]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[13]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[12]/Ras/GEF*/diff /kinetics/chain/kinetics[13]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[13]/Ras/GEF*/diff /kinetics/chain/kinetics[13]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/GEF* /kinetics/chain/kinetics[13]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[13]/Ras/GDP-Ras /kinetics/chain/kinetics[13]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/GEF* /kinetics/chain/kinetics[13]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/GEF* /kinetics/chain/kinetics[13]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ras-act-craf /kinetics/chain/kinetics[13]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[13]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[13]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[13]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[13]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[13]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[13]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[13]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[13]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[13]/Ras-act-unphosph-raf /kinetics/chain/kinetics[13]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[13]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[13]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[13]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[13]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[13]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[13]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[13]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[13]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[13]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[13]/Ras/GTP-Ras /kinetics/chain/kinetics[13]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/GDP-Ras /kinetics/chain/kinetics[13]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ras/GAP* /kinetics/chain/kinetics[13]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/GAP /kinetics/chain/kinetics[13]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[13]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[13]/Ras/dephosph-GAP /kinetics/chain/kinetics[13]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/GAP*/diff /kinetics/chain/kinetics[13]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[13]/Ras/GAP*/diff /kinetics/chain/kinetics[13]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/GAP* /kinetics/chain/kinetics[13]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/GAP* /kinetics/chain/kinetics[13]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[13]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[13]/Ras/dephosph-GAP /kinetics/chain/kinetics[13]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[13]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[13]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[12]/Ras/GAP/diff /kinetics/chain/kinetics[13]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[13]/Ras/GAP/diff /kinetics/chain/kinetics[13]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/GTP-Ras /kinetics/chain/kinetics[13]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/GAP /kinetics/chain/kinetics[13]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[13]/Ras/GAP /kinetics/chain/kinetics[13]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/GAP /kinetics/chain/kinetics[13]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF /kinetics/chain/kinetics[13]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/CaM-GEF /kinetics/chain/kinetics[13]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca4 /kinetics/chain/kinetics[13]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[13]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[13]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[13]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[12]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[13]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[13]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[13]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/GDP-Ras /kinetics/chain/kinetics[13]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/CaM-GEF /kinetics/chain/kinetics[13]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[13]/Ras/CaM-GEF /kinetics/chain/kinetics[13]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/CaM-GEF /kinetics/chain/kinetics[13]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[13]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM/diff /kinetics/chain/kinetics[13]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[13]/CaM/CaM/diff /kinetics/chain/kinetics[13]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM /kinetics/chain/kinetics[13]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM /kinetics/chain/kinetics[13]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca3 /kinetics/chain/kinetics[13]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca4 /kinetics/chain/kinetics[13]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[13]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[13]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca3 /kinetics/chain/kinetics[13]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca3 /kinetics/chain/kinetics[13]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[13]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[13]/PKM/trigger_PKM /kinetics/chain/kinetics[13]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[13]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[13]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca4 /kinetics/chain/kinetics[13]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 /kinetics/chain/kinetics[13]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/CaM/CaM /kinetics/chain/kinetics[13]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca /kinetics/chain/kinetics[13]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ca /kinetics/chain/kinetics[13]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[13]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[13]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca2 /kinetics/chain/kinetics[13]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca2 /kinetics/chain/kinetics[13]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca3 /kinetics/chain/kinetics[13]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca2 /kinetics/chain/kinetics[13]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca2 /kinetics/chain/kinetics[13]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[13]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[13]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[13]/Ca REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[13]/Ca REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[13]/Ca REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[13]/Ca REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[13]/Ca REAC A B addmsg /kinetics/chain/kinetics[13]/Ca_diff /kinetics/chain/kinetics[13]/Ca REAC B A addmsg /kinetics/chain/kinetics[12]/Ca/diff /kinetics/chain/kinetics[13]/Ca REAC B A addmsg /kinetics/chain/kinetics[13]/Ca/diff /kinetics/chain/kinetics[13]/Ca REAC A B addmsg /kinetics/chain/kinetics[13]/Ca /kinetics/chain/kinetics[13]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ca /kinetics/chain/kinetics[13]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1 /kinetics/chain/kinetics[13]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[13]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ras/GTP-Ras /kinetics/chain/kinetics[13]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKM/trigger_PKM /kinetics/chain/kinetics[13]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[12]/PKM/Ca_detector/diff /kinetics/chain/kinetics[13]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[13]/PKM/Ca_detector/diff /kinetics/chain/kinetics[13]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[13]/PKM/Ca_detector /kinetics/chain/kinetics[13]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKM/Ca_detector /kinetics/chain/kinetics[13]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[13]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[13]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[13]/PKM/turn_off_activator /kinetics/chain/kinetics[13]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[12]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[13]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[13]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[13]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[13]/PKM/PKM_synthesis /kinetics/chain/kinetics[13]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[13]/PKM/AA_pool /kinetics/chain/kinetics[13]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKM/PKM_synthesis /kinetics/chain/kinetics[13]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKM/PKM_synthesis /kinetics/chain/kinetics[13]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[13]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[13]/PKC/PKM-zeta /kinetics/chain/kinetics[13]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKM/degraded_PKM /kinetics/chain/kinetics[13]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKM/PKM_degradation /kinetics/chain/kinetics[13]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[13]/PKM/trigger_PKM /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[13]/PKM/PKM_activator /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[13]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[13]/PKM/turn_off_activator /kinetics/chain/kinetics[13]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[12]/PKM/PKM_activator/diff /kinetics/chain/kinetics[13]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[13]/PKM/PKM_activator/diff /kinetics/chain/kinetics[13]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[13]/PKM/PKM_activator /kinetics/chain/kinetics[13]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKM/PKM_activator /kinetics/chain/kinetics[13]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKM/PKM_synthesis /kinetics/chain/kinetics[13]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKM/PKM_activator /kinetics/chain/kinetics[13]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca4 /kinetics/chain/kinetics[13]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKM/Ca_detector /kinetics/chain/kinetics[13]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex /kinetics/chain/kinetics[13]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ca_diff /kinetics/chain/kinetics[13]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[13]/Ca /kinetics/chain/kinetics[13]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ca_input /kinetics/chain/kinetics[13]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[14]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[14]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[14]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[14]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[14]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca /kinetics/chain/kinetics[14]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca /kinetics/chain/kinetics[14]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ca /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca /kinetics/chain/kinetics[14]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[14]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[14]/DAG /kinetics/chain/kinetics[14]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca /kinetics/chain/kinetics[14]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[14]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[14]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[14]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/DAG /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG /kinetics/chain/kinetics[14]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[14]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[14]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG /kinetics/chain/kinetics[14]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG /kinetics/chain/kinetics[14]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[14]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[14]/PKM/PKM_degradation /kinetics/chain/kinetics[14]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[14]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[14]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKM-zeta /kinetics/chain/kinetics[14]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKM-zeta /kinetics/chain/kinetics[14]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[14]/DAG REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG /kinetics/chain/kinetics[14]/DAG REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[14]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[14]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[14]/PKC/PKM-zeta /kinetics/chain/kinetics[14]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[14]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[14]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[14]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[14]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[14]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[14]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[14]/PKC-active /kinetics/chain/kinetics[14]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1 /kinetics/chain/kinetics[14]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC-active /kinetics/chain/kinetics[14]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[14]/Ras/GAP /kinetics/chain/kinetics[14]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC-active /kinetics/chain/kinetics[14]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF /kinetics/chain/kinetics[14]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[14]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[14]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[14]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[13]/MAPK*/diff /kinetics/chain/kinetics[14]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[14]/MAPK*/diff /kinetics/chain/kinetics[14]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[14]/MAPK* /kinetics/chain/kinetics[14]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1* /kinetics/chain/kinetics[14]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK* /kinetics/chain/kinetics[14]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK* /kinetics/chain/kinetics[14]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[14]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[14]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[14]/Ras-act-unphosph-raf /kinetics/chain/kinetics[14]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[14]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[14]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[14]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[14]/Ras-act-craf /kinetics/chain/kinetics[14]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[14]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[14]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[14]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[14]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[14]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[14]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[14]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[14]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK/diff /kinetics/chain/kinetics[14]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK/diff /kinetics/chain/kinetics[14]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK /kinetics/chain/kinetics[14]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK /kinetics/chain/kinetics[14]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[14]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[14]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[14]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[14]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[14]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[14]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[14]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[14]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[14]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK* /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK* /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[14]/Ras-act-unphosph-raf /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[14]/Ras-act-craf /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[14]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[14]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[14]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[14]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[13]/MKP-1/diff /kinetics/chain/kinetics[14]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[14]/MKP-1/diff /kinetics/chain/kinetics[14]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr /kinetics/chain/kinetics[14]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MKP-1 /kinetics/chain/kinetics[14]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK* /kinetics/chain/kinetics[14]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MKP-1 /kinetics/chain/kinetics[14]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[14]/MKP-1 /kinetics/chain/kinetics[14]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MKP-1 /kinetics/chain/kinetics[14]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1* /kinetics/chain/kinetics[14]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[14]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ras/GTP-Ras /kinetics/chain/kinetics[14]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[14]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[14]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[14]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[14]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/diff /kinetics/chain/kinetics[14]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/diff /kinetics/chain/kinetics[14]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1* /kinetics/chain/kinetics[14]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A /kinetics/chain/kinetics[14]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK* /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1** /kinetics/chain/kinetics[14]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A /kinetics/chain/kinetics[14]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A /kinetics/chain/kinetics[14]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A /kinetics/chain/kinetics[14]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF /kinetics/chain/kinetics[14]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ras/GEF* /kinetics/chain/kinetics[14]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[14]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[14]/Ras/dephosph-GEF /kinetics/chain/kinetics[14]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[14]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[14]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[14]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF/diff /kinetics/chain/kinetics[14]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF/diff /kinetics/chain/kinetics[14]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF /kinetics/chain/kinetics[14]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[14]/Ras/GDP-Ras /kinetics/chain/kinetics[14]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF /kinetics/chain/kinetics[14]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF /kinetics/chain/kinetics[14]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[14]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[14]/Ras/dephosph-GEF /kinetics/chain/kinetics[14]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[14]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[13]/Ras/GEF*/diff /kinetics/chain/kinetics[14]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[14]/Ras/GEF*/diff /kinetics/chain/kinetics[14]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/GEF* /kinetics/chain/kinetics[14]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[14]/Ras/GDP-Ras /kinetics/chain/kinetics[14]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/GEF* /kinetics/chain/kinetics[14]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/GEF* /kinetics/chain/kinetics[14]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ras-act-craf /kinetics/chain/kinetics[14]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[14]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[14]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[14]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[14]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[14]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[14]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[14]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[14]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[14]/Ras-act-unphosph-raf /kinetics/chain/kinetics[14]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[14]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[14]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[14]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[14]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[14]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[14]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[14]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[14]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[14]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[14]/Ras/GTP-Ras /kinetics/chain/kinetics[14]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/GDP-Ras /kinetics/chain/kinetics[14]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ras/GAP* /kinetics/chain/kinetics[14]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/GAP /kinetics/chain/kinetics[14]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[14]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[14]/Ras/dephosph-GAP /kinetics/chain/kinetics[14]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/GAP*/diff /kinetics/chain/kinetics[14]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[14]/Ras/GAP*/diff /kinetics/chain/kinetics[14]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/GAP* /kinetics/chain/kinetics[14]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/GAP* /kinetics/chain/kinetics[14]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[14]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[14]/Ras/dephosph-GAP /kinetics/chain/kinetics[14]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[14]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[14]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[13]/Ras/GAP/diff /kinetics/chain/kinetics[14]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[14]/Ras/GAP/diff /kinetics/chain/kinetics[14]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/GTP-Ras /kinetics/chain/kinetics[14]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/GAP /kinetics/chain/kinetics[14]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[14]/Ras/GAP /kinetics/chain/kinetics[14]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/GAP /kinetics/chain/kinetics[14]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF /kinetics/chain/kinetics[14]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/CaM-GEF /kinetics/chain/kinetics[14]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 /kinetics/chain/kinetics[14]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[14]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[14]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[14]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[13]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[14]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[14]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[14]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/GDP-Ras /kinetics/chain/kinetics[14]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/CaM-GEF /kinetics/chain/kinetics[14]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[14]/Ras/CaM-GEF /kinetics/chain/kinetics[14]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/CaM-GEF /kinetics/chain/kinetics[14]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[14]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM/diff /kinetics/chain/kinetics[14]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[14]/CaM/CaM/diff /kinetics/chain/kinetics[14]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM /kinetics/chain/kinetics[14]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM /kinetics/chain/kinetics[14]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca3 /kinetics/chain/kinetics[14]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 /kinetics/chain/kinetics[14]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[14]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[14]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca3 /kinetics/chain/kinetics[14]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca3 /kinetics/chain/kinetics[14]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[14]/PKM/trigger_PKM /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 /kinetics/chain/kinetics[14]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca4 /kinetics/chain/kinetics[14]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/CaM/CaM /kinetics/chain/kinetics[14]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca /kinetics/chain/kinetics[14]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ca /kinetics/chain/kinetics[14]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[14]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[14]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca2 /kinetics/chain/kinetics[14]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca2 /kinetics/chain/kinetics[14]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca3 /kinetics/chain/kinetics[14]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca2 /kinetics/chain/kinetics[14]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca2 /kinetics/chain/kinetics[14]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[14]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[14]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[14]/Ca REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[14]/Ca REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[14]/Ca REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[14]/Ca REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[14]/Ca REAC A B addmsg /kinetics/chain/kinetics[14]/Ca_diff /kinetics/chain/kinetics[14]/Ca REAC B A addmsg /kinetics/chain/kinetics[13]/Ca/diff /kinetics/chain/kinetics[14]/Ca REAC B A addmsg /kinetics/chain/kinetics[14]/Ca/diff /kinetics/chain/kinetics[14]/Ca REAC A B addmsg /kinetics/chain/kinetics[14]/Ca /kinetics/chain/kinetics[14]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ca /kinetics/chain/kinetics[14]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1 /kinetics/chain/kinetics[14]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[14]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ras/GTP-Ras /kinetics/chain/kinetics[14]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKM/trigger_PKM /kinetics/chain/kinetics[14]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[13]/PKM/Ca_detector/diff /kinetics/chain/kinetics[14]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[14]/PKM/Ca_detector/diff /kinetics/chain/kinetics[14]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[14]/PKM/Ca_detector /kinetics/chain/kinetics[14]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKM/Ca_detector /kinetics/chain/kinetics[14]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[14]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[14]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[14]/PKM/turn_off_activator /kinetics/chain/kinetics[14]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[13]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[14]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[14]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[14]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[14]/PKM/PKM_synthesis /kinetics/chain/kinetics[14]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[14]/PKM/AA_pool /kinetics/chain/kinetics[14]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKM/PKM_synthesis /kinetics/chain/kinetics[14]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKM/PKM_synthesis /kinetics/chain/kinetics[14]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[14]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[14]/PKC/PKM-zeta /kinetics/chain/kinetics[14]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKM/degraded_PKM /kinetics/chain/kinetics[14]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKM/PKM_degradation /kinetics/chain/kinetics[14]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[14]/PKM/trigger_PKM /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[14]/PKM/PKM_activator /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[14]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[14]/PKM/turn_off_activator /kinetics/chain/kinetics[14]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[13]/PKM/PKM_activator/diff /kinetics/chain/kinetics[14]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[14]/PKM/PKM_activator/diff /kinetics/chain/kinetics[14]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[14]/PKM/PKM_activator /kinetics/chain/kinetics[14]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKM/PKM_activator /kinetics/chain/kinetics[14]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKM/PKM_synthesis /kinetics/chain/kinetics[14]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKM/PKM_activator /kinetics/chain/kinetics[14]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 /kinetics/chain/kinetics[14]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKM/Ca_detector /kinetics/chain/kinetics[14]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex /kinetics/chain/kinetics[14]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ca_diff /kinetics/chain/kinetics[14]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[14]/Ca /kinetics/chain/kinetics[14]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ca_input /kinetics/chain/kinetics[14]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[15]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[15]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[15]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[15]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[15]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca /kinetics/chain/kinetics[15]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca /kinetics/chain/kinetics[15]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ca /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca /kinetics/chain/kinetics[15]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[15]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[15]/DAG /kinetics/chain/kinetics[15]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca /kinetics/chain/kinetics[15]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[15]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[15]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[15]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/DAG /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG /kinetics/chain/kinetics[15]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[15]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[15]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG /kinetics/chain/kinetics[15]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG /kinetics/chain/kinetics[15]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[15]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[15]/PKM/PKM_degradation /kinetics/chain/kinetics[15]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[15]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[15]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKM-zeta /kinetics/chain/kinetics[15]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKM-zeta /kinetics/chain/kinetics[15]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[15]/DAG REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG /kinetics/chain/kinetics[15]/DAG REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[15]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[15]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[15]/PKC/PKM-zeta /kinetics/chain/kinetics[15]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[15]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[15]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[15]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[15]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[15]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[15]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[15]/PKC-active /kinetics/chain/kinetics[15]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1 /kinetics/chain/kinetics[15]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC-active /kinetics/chain/kinetics[15]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[15]/Ras/GAP /kinetics/chain/kinetics[15]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC-active /kinetics/chain/kinetics[15]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF /kinetics/chain/kinetics[15]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[15]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[15]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[15]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[14]/MAPK*/diff /kinetics/chain/kinetics[15]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[15]/MAPK*/diff /kinetics/chain/kinetics[15]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[15]/MAPK* /kinetics/chain/kinetics[15]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1* /kinetics/chain/kinetics[15]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK* /kinetics/chain/kinetics[15]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK* /kinetics/chain/kinetics[15]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[15]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[15]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[15]/Ras-act-unphosph-raf /kinetics/chain/kinetics[15]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[15]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[15]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[15]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[15]/Ras-act-craf /kinetics/chain/kinetics[15]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[15]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[15]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[15]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[15]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[15]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[15]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[15]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[15]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK/diff /kinetics/chain/kinetics[15]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK/diff /kinetics/chain/kinetics[15]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK /kinetics/chain/kinetics[15]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK /kinetics/chain/kinetics[15]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[15]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[15]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[15]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[15]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[15]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[15]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[15]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[15]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[15]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK* /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK* /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[15]/Ras-act-unphosph-raf /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[15]/Ras-act-craf /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[15]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[15]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[15]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[15]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[14]/MKP-1/diff /kinetics/chain/kinetics[15]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[15]/MKP-1/diff /kinetics/chain/kinetics[15]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr /kinetics/chain/kinetics[15]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MKP-1 /kinetics/chain/kinetics[15]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK* /kinetics/chain/kinetics[15]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MKP-1 /kinetics/chain/kinetics[15]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[15]/MKP-1 /kinetics/chain/kinetics[15]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MKP-1 /kinetics/chain/kinetics[15]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1* /kinetics/chain/kinetics[15]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[15]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ras/GTP-Ras /kinetics/chain/kinetics[15]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[15]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[15]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[15]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[15]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/diff /kinetics/chain/kinetics[15]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/diff /kinetics/chain/kinetics[15]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1* /kinetics/chain/kinetics[15]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A /kinetics/chain/kinetics[15]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK* /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1** /kinetics/chain/kinetics[15]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A /kinetics/chain/kinetics[15]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A /kinetics/chain/kinetics[15]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A /kinetics/chain/kinetics[15]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF /kinetics/chain/kinetics[15]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ras/GEF* /kinetics/chain/kinetics[15]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[15]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[15]/Ras/dephosph-GEF /kinetics/chain/kinetics[15]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[15]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[15]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[15]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF/diff /kinetics/chain/kinetics[15]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF/diff /kinetics/chain/kinetics[15]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF /kinetics/chain/kinetics[15]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[15]/Ras/GDP-Ras /kinetics/chain/kinetics[15]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF /kinetics/chain/kinetics[15]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF /kinetics/chain/kinetics[15]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[15]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[15]/Ras/dephosph-GEF /kinetics/chain/kinetics[15]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[15]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[14]/Ras/GEF*/diff /kinetics/chain/kinetics[15]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[15]/Ras/GEF*/diff /kinetics/chain/kinetics[15]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/GEF* /kinetics/chain/kinetics[15]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[15]/Ras/GDP-Ras /kinetics/chain/kinetics[15]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/GEF* /kinetics/chain/kinetics[15]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/GEF* /kinetics/chain/kinetics[15]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ras-act-craf /kinetics/chain/kinetics[15]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[15]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[15]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[15]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[15]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[15]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[15]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[15]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[15]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[15]/Ras-act-unphosph-raf /kinetics/chain/kinetics[15]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[15]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[15]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[15]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[15]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[15]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[15]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[15]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[15]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[15]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[15]/Ras/GTP-Ras /kinetics/chain/kinetics[15]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/GDP-Ras /kinetics/chain/kinetics[15]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ras/GAP* /kinetics/chain/kinetics[15]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/GAP /kinetics/chain/kinetics[15]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[15]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[15]/Ras/dephosph-GAP /kinetics/chain/kinetics[15]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/GAP*/diff /kinetics/chain/kinetics[15]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[15]/Ras/GAP*/diff /kinetics/chain/kinetics[15]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/GAP* /kinetics/chain/kinetics[15]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/GAP* /kinetics/chain/kinetics[15]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[15]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[15]/Ras/dephosph-GAP /kinetics/chain/kinetics[15]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[15]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[15]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[14]/Ras/GAP/diff /kinetics/chain/kinetics[15]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[15]/Ras/GAP/diff /kinetics/chain/kinetics[15]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/GTP-Ras /kinetics/chain/kinetics[15]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/GAP /kinetics/chain/kinetics[15]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[15]/Ras/GAP /kinetics/chain/kinetics[15]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/GAP /kinetics/chain/kinetics[15]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF /kinetics/chain/kinetics[15]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/CaM-GEF /kinetics/chain/kinetics[15]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca4 /kinetics/chain/kinetics[15]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[15]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[15]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[15]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[14]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[15]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[15]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[15]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/GDP-Ras /kinetics/chain/kinetics[15]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/CaM-GEF /kinetics/chain/kinetics[15]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[15]/Ras/CaM-GEF /kinetics/chain/kinetics[15]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/CaM-GEF /kinetics/chain/kinetics[15]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[15]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM/diff /kinetics/chain/kinetics[15]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[15]/CaM/CaM/diff /kinetics/chain/kinetics[15]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM /kinetics/chain/kinetics[15]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM /kinetics/chain/kinetics[15]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca3 /kinetics/chain/kinetics[15]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca4 /kinetics/chain/kinetics[15]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[15]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[15]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca3 /kinetics/chain/kinetics[15]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca3 /kinetics/chain/kinetics[15]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[15]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[15]/PKM/trigger_PKM /kinetics/chain/kinetics[15]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[15]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[15]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca4 /kinetics/chain/kinetics[15]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca4 /kinetics/chain/kinetics[15]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/CaM/CaM /kinetics/chain/kinetics[15]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca /kinetics/chain/kinetics[15]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ca /kinetics/chain/kinetics[15]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[15]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[15]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca2 /kinetics/chain/kinetics[15]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca2 /kinetics/chain/kinetics[15]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca3 /kinetics/chain/kinetics[15]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca2 /kinetics/chain/kinetics[15]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca2 /kinetics/chain/kinetics[15]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[15]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[15]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[15]/Ca REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[15]/Ca REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[15]/Ca REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[15]/Ca REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[15]/Ca REAC A B addmsg /kinetics/chain/kinetics[15]/Ca_diff /kinetics/chain/kinetics[15]/Ca REAC B A addmsg /kinetics/chain/kinetics[14]/Ca/diff /kinetics/chain/kinetics[15]/Ca REAC B A addmsg /kinetics/chain/kinetics[15]/Ca/diff /kinetics/chain/kinetics[15]/Ca REAC A B addmsg /kinetics/chain/kinetics[15]/Ca /kinetics/chain/kinetics[15]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ca /kinetics/chain/kinetics[15]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1 /kinetics/chain/kinetics[15]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[15]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ras/GTP-Ras /kinetics/chain/kinetics[15]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKM/trigger_PKM /kinetics/chain/kinetics[15]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[14]/PKM/Ca_detector/diff /kinetics/chain/kinetics[15]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[15]/PKM/Ca_detector/diff /kinetics/chain/kinetics[15]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[15]/PKM/Ca_detector /kinetics/chain/kinetics[15]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKM/Ca_detector /kinetics/chain/kinetics[15]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[15]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[15]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[15]/PKM/turn_off_activator /kinetics/chain/kinetics[15]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[14]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[15]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[15]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[15]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[15]/PKM/PKM_synthesis /kinetics/chain/kinetics[15]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[15]/PKM/AA_pool /kinetics/chain/kinetics[15]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKM/PKM_synthesis /kinetics/chain/kinetics[15]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKM/PKM_synthesis /kinetics/chain/kinetics[15]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[15]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[15]/PKC/PKM-zeta /kinetics/chain/kinetics[15]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKM/degraded_PKM /kinetics/chain/kinetics[15]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKM/PKM_degradation /kinetics/chain/kinetics[15]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[15]/PKM/trigger_PKM /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[15]/PKM/PKM_activator /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[15]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[15]/PKM/turn_off_activator /kinetics/chain/kinetics[15]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[14]/PKM/PKM_activator/diff /kinetics/chain/kinetics[15]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[15]/PKM/PKM_activator/diff /kinetics/chain/kinetics[15]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[15]/PKM/PKM_activator /kinetics/chain/kinetics[15]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKM/PKM_activator /kinetics/chain/kinetics[15]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKM/PKM_synthesis /kinetics/chain/kinetics[15]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKM/PKM_activator /kinetics/chain/kinetics[15]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca4 /kinetics/chain/kinetics[15]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKM/Ca_detector /kinetics/chain/kinetics[15]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex /kinetics/chain/kinetics[15]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ca_diff /kinetics/chain/kinetics[15]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[15]/Ca /kinetics/chain/kinetics[15]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ca_input /kinetics/chain/kinetics[15]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[16]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[16]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[16]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[16]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[16]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca /kinetics/chain/kinetics[16]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca /kinetics/chain/kinetics[16]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ca /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca /kinetics/chain/kinetics[16]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[16]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[16]/DAG /kinetics/chain/kinetics[16]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca /kinetics/chain/kinetics[16]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[16]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[16]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[16]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/DAG /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG /kinetics/chain/kinetics[16]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[16]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[16]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG /kinetics/chain/kinetics[16]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG /kinetics/chain/kinetics[16]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[16]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[16]/PKM/PKM_degradation /kinetics/chain/kinetics[16]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[16]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[16]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKM-zeta /kinetics/chain/kinetics[16]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKM-zeta /kinetics/chain/kinetics[16]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[16]/DAG REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG /kinetics/chain/kinetics[16]/DAG REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[16]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[16]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[16]/PKC/PKM-zeta /kinetics/chain/kinetics[16]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[16]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[16]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[16]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[16]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[16]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[16]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[16]/PKC-active /kinetics/chain/kinetics[16]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1 /kinetics/chain/kinetics[16]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC-active /kinetics/chain/kinetics[16]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[16]/Ras/GAP /kinetics/chain/kinetics[16]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC-active /kinetics/chain/kinetics[16]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF /kinetics/chain/kinetics[16]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[16]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[16]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[16]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[15]/MAPK*/diff /kinetics/chain/kinetics[16]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[16]/MAPK*/diff /kinetics/chain/kinetics[16]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[16]/MAPK* /kinetics/chain/kinetics[16]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1* /kinetics/chain/kinetics[16]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK* /kinetics/chain/kinetics[16]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK* /kinetics/chain/kinetics[16]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[16]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[16]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[16]/Ras-act-unphosph-raf /kinetics/chain/kinetics[16]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[16]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[16]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[16]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[16]/Ras-act-craf /kinetics/chain/kinetics[16]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[16]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[16]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[16]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[16]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[16]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[16]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[16]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[16]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK/diff /kinetics/chain/kinetics[16]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK/diff /kinetics/chain/kinetics[16]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK /kinetics/chain/kinetics[16]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK /kinetics/chain/kinetics[16]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[16]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[16]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[16]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[16]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[16]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[16]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[16]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[16]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[16]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK* /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK* /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[16]/Ras-act-unphosph-raf /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[16]/Ras-act-craf /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[16]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[16]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[16]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[16]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[15]/MKP-1/diff /kinetics/chain/kinetics[16]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[16]/MKP-1/diff /kinetics/chain/kinetics[16]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr /kinetics/chain/kinetics[16]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MKP-1 /kinetics/chain/kinetics[16]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK* /kinetics/chain/kinetics[16]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MKP-1 /kinetics/chain/kinetics[16]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[16]/MKP-1 /kinetics/chain/kinetics[16]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MKP-1 /kinetics/chain/kinetics[16]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1* /kinetics/chain/kinetics[16]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[16]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ras/GTP-Ras /kinetics/chain/kinetics[16]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[16]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[16]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[16]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[16]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/diff /kinetics/chain/kinetics[16]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/diff /kinetics/chain/kinetics[16]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1* /kinetics/chain/kinetics[16]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A /kinetics/chain/kinetics[16]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK* /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1** /kinetics/chain/kinetics[16]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A /kinetics/chain/kinetics[16]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A /kinetics/chain/kinetics[16]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A /kinetics/chain/kinetics[16]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF /kinetics/chain/kinetics[16]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ras/GEF* /kinetics/chain/kinetics[16]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[16]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[16]/Ras/dephosph-GEF /kinetics/chain/kinetics[16]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[16]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[16]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[16]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF/diff /kinetics/chain/kinetics[16]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF/diff /kinetics/chain/kinetics[16]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF /kinetics/chain/kinetics[16]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[16]/Ras/GDP-Ras /kinetics/chain/kinetics[16]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF /kinetics/chain/kinetics[16]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF /kinetics/chain/kinetics[16]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[16]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[16]/Ras/dephosph-GEF /kinetics/chain/kinetics[16]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[16]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[15]/Ras/GEF*/diff /kinetics/chain/kinetics[16]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[16]/Ras/GEF*/diff /kinetics/chain/kinetics[16]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/GEF* /kinetics/chain/kinetics[16]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[16]/Ras/GDP-Ras /kinetics/chain/kinetics[16]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/GEF* /kinetics/chain/kinetics[16]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/GEF* /kinetics/chain/kinetics[16]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ras-act-craf /kinetics/chain/kinetics[16]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[16]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[16]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[16]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[16]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[16]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[16]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[16]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[16]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[16]/Ras-act-unphosph-raf /kinetics/chain/kinetics[16]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[16]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[16]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[16]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[16]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[16]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[16]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[16]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[16]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[16]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[16]/Ras/GTP-Ras /kinetics/chain/kinetics[16]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/GDP-Ras /kinetics/chain/kinetics[16]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ras/GAP* /kinetics/chain/kinetics[16]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/GAP /kinetics/chain/kinetics[16]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[16]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[16]/Ras/dephosph-GAP /kinetics/chain/kinetics[16]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/GAP*/diff /kinetics/chain/kinetics[16]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[16]/Ras/GAP*/diff /kinetics/chain/kinetics[16]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/GAP* /kinetics/chain/kinetics[16]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/GAP* /kinetics/chain/kinetics[16]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[16]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[16]/Ras/dephosph-GAP /kinetics/chain/kinetics[16]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[16]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[16]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[15]/Ras/GAP/diff /kinetics/chain/kinetics[16]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[16]/Ras/GAP/diff /kinetics/chain/kinetics[16]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/GTP-Ras /kinetics/chain/kinetics[16]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/GAP /kinetics/chain/kinetics[16]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[16]/Ras/GAP /kinetics/chain/kinetics[16]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/GAP /kinetics/chain/kinetics[16]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF /kinetics/chain/kinetics[16]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/CaM-GEF /kinetics/chain/kinetics[16]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca4 /kinetics/chain/kinetics[16]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[16]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[16]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[16]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[15]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[16]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[16]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[16]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/GDP-Ras /kinetics/chain/kinetics[16]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/CaM-GEF /kinetics/chain/kinetics[16]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[16]/Ras/CaM-GEF /kinetics/chain/kinetics[16]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/CaM-GEF /kinetics/chain/kinetics[16]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[16]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM/diff /kinetics/chain/kinetics[16]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[16]/CaM/CaM/diff /kinetics/chain/kinetics[16]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM /kinetics/chain/kinetics[16]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM /kinetics/chain/kinetics[16]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca3 /kinetics/chain/kinetics[16]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca4 /kinetics/chain/kinetics[16]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[16]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[16]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca3 /kinetics/chain/kinetics[16]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca3 /kinetics/chain/kinetics[16]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[16]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[16]/PKM/trigger_PKM /kinetics/chain/kinetics[16]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[16]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[16]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca4 /kinetics/chain/kinetics[16]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 /kinetics/chain/kinetics[16]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/CaM/CaM /kinetics/chain/kinetics[16]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca /kinetics/chain/kinetics[16]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ca /kinetics/chain/kinetics[16]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[16]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[16]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca2 /kinetics/chain/kinetics[16]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca2 /kinetics/chain/kinetics[16]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca3 /kinetics/chain/kinetics[16]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca2 /kinetics/chain/kinetics[16]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca2 /kinetics/chain/kinetics[16]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[16]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[16]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[16]/Ca REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[16]/Ca REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[16]/Ca REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[16]/Ca REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[16]/Ca REAC A B addmsg /kinetics/chain/kinetics[16]/Ca_diff /kinetics/chain/kinetics[16]/Ca REAC B A addmsg /kinetics/chain/kinetics[15]/Ca/diff /kinetics/chain/kinetics[16]/Ca REAC B A addmsg /kinetics/chain/kinetics[16]/Ca/diff /kinetics/chain/kinetics[16]/Ca REAC A B addmsg /kinetics/chain/kinetics[16]/Ca /kinetics/chain/kinetics[16]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ca /kinetics/chain/kinetics[16]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1 /kinetics/chain/kinetics[16]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[16]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ras/GTP-Ras /kinetics/chain/kinetics[16]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKM/trigger_PKM /kinetics/chain/kinetics[16]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[15]/PKM/Ca_detector/diff /kinetics/chain/kinetics[16]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[16]/PKM/Ca_detector/diff /kinetics/chain/kinetics[16]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[16]/PKM/Ca_detector /kinetics/chain/kinetics[16]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKM/Ca_detector /kinetics/chain/kinetics[16]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[16]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[16]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[16]/PKM/turn_off_activator /kinetics/chain/kinetics[16]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[15]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[16]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[16]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[16]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[16]/PKM/PKM_synthesis /kinetics/chain/kinetics[16]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[16]/PKM/AA_pool /kinetics/chain/kinetics[16]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKM/PKM_synthesis /kinetics/chain/kinetics[16]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKM/PKM_synthesis /kinetics/chain/kinetics[16]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[16]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[16]/PKC/PKM-zeta /kinetics/chain/kinetics[16]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKM/degraded_PKM /kinetics/chain/kinetics[16]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKM/PKM_degradation /kinetics/chain/kinetics[16]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[16]/PKM/trigger_PKM /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[16]/PKM/PKM_activator /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[16]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[16]/PKM/turn_off_activator /kinetics/chain/kinetics[16]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[15]/PKM/PKM_activator/diff /kinetics/chain/kinetics[16]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[16]/PKM/PKM_activator/diff /kinetics/chain/kinetics[16]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[16]/PKM/PKM_activator /kinetics/chain/kinetics[16]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKM/PKM_activator /kinetics/chain/kinetics[16]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKM/PKM_synthesis /kinetics/chain/kinetics[16]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKM/PKM_activator /kinetics/chain/kinetics[16]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca4 /kinetics/chain/kinetics[16]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKM/Ca_detector /kinetics/chain/kinetics[16]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex /kinetics/chain/kinetics[16]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ca_diff /kinetics/chain/kinetics[16]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[16]/Ca /kinetics/chain/kinetics[16]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ca_input /kinetics/chain/kinetics[16]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[17]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[17]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[17]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[17]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[17]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca /kinetics/chain/kinetics[17]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca /kinetics/chain/kinetics[17]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ca /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca /kinetics/chain/kinetics[17]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[17]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[17]/DAG /kinetics/chain/kinetics[17]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca /kinetics/chain/kinetics[17]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[17]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[17]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[17]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/DAG /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG /kinetics/chain/kinetics[17]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[17]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[17]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG /kinetics/chain/kinetics[17]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG /kinetics/chain/kinetics[17]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[17]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[17]/PKM/PKM_degradation /kinetics/chain/kinetics[17]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[17]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[17]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKM-zeta /kinetics/chain/kinetics[17]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKM-zeta /kinetics/chain/kinetics[17]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[17]/DAG REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG /kinetics/chain/kinetics[17]/DAG REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[17]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[17]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[17]/PKC/PKM-zeta /kinetics/chain/kinetics[17]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[17]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[17]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[17]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[17]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[17]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[17]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[17]/PKC-active /kinetics/chain/kinetics[17]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1 /kinetics/chain/kinetics[17]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC-active /kinetics/chain/kinetics[17]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[17]/Ras/GAP /kinetics/chain/kinetics[17]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC-active /kinetics/chain/kinetics[17]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF /kinetics/chain/kinetics[17]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[17]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[17]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[17]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[16]/MAPK*/diff /kinetics/chain/kinetics[17]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[17]/MAPK*/diff /kinetics/chain/kinetics[17]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[17]/MAPK* /kinetics/chain/kinetics[17]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1* /kinetics/chain/kinetics[17]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK* /kinetics/chain/kinetics[17]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK* /kinetics/chain/kinetics[17]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[17]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[17]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[17]/Ras-act-unphosph-raf /kinetics/chain/kinetics[17]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[17]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[17]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[17]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[17]/Ras-act-craf /kinetics/chain/kinetics[17]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[17]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[17]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[17]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[17]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[17]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[17]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[17]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[17]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK/diff /kinetics/chain/kinetics[17]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK/diff /kinetics/chain/kinetics[17]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK /kinetics/chain/kinetics[17]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK /kinetics/chain/kinetics[17]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[17]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[17]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[17]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[17]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[17]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[17]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[17]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[17]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[17]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK* /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK* /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[17]/Ras-act-unphosph-raf /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[17]/Ras-act-craf /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[17]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[17]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[17]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[17]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[16]/MKP-1/diff /kinetics/chain/kinetics[17]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[17]/MKP-1/diff /kinetics/chain/kinetics[17]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr /kinetics/chain/kinetics[17]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MKP-1 /kinetics/chain/kinetics[17]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK* /kinetics/chain/kinetics[17]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MKP-1 /kinetics/chain/kinetics[17]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[17]/MKP-1 /kinetics/chain/kinetics[17]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MKP-1 /kinetics/chain/kinetics[17]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1* /kinetics/chain/kinetics[17]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[17]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ras/GTP-Ras /kinetics/chain/kinetics[17]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[17]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[17]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[17]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[17]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/diff /kinetics/chain/kinetics[17]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/diff /kinetics/chain/kinetics[17]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1* /kinetics/chain/kinetics[17]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A /kinetics/chain/kinetics[17]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK* /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1** /kinetics/chain/kinetics[17]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A /kinetics/chain/kinetics[17]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A /kinetics/chain/kinetics[17]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A /kinetics/chain/kinetics[17]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF /kinetics/chain/kinetics[17]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ras/GEF* /kinetics/chain/kinetics[17]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[17]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[17]/Ras/dephosph-GEF /kinetics/chain/kinetics[17]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[17]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[17]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[17]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF/diff /kinetics/chain/kinetics[17]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF/diff /kinetics/chain/kinetics[17]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF /kinetics/chain/kinetics[17]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[17]/Ras/GDP-Ras /kinetics/chain/kinetics[17]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF /kinetics/chain/kinetics[17]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF /kinetics/chain/kinetics[17]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[17]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[17]/Ras/dephosph-GEF /kinetics/chain/kinetics[17]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[17]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[16]/Ras/GEF*/diff /kinetics/chain/kinetics[17]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[17]/Ras/GEF*/diff /kinetics/chain/kinetics[17]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/GEF* /kinetics/chain/kinetics[17]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[17]/Ras/GDP-Ras /kinetics/chain/kinetics[17]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/GEF* /kinetics/chain/kinetics[17]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/GEF* /kinetics/chain/kinetics[17]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ras-act-craf /kinetics/chain/kinetics[17]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[17]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[17]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[17]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[17]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[17]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[17]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[17]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[17]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[17]/Ras-act-unphosph-raf /kinetics/chain/kinetics[17]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[17]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[17]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[17]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[17]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[17]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[17]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[17]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[17]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[17]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[17]/Ras/GTP-Ras /kinetics/chain/kinetics[17]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/GDP-Ras /kinetics/chain/kinetics[17]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ras/GAP* /kinetics/chain/kinetics[17]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/GAP /kinetics/chain/kinetics[17]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[17]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[17]/Ras/dephosph-GAP /kinetics/chain/kinetics[17]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/GAP*/diff /kinetics/chain/kinetics[17]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[17]/Ras/GAP*/diff /kinetics/chain/kinetics[17]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/GAP* /kinetics/chain/kinetics[17]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/GAP* /kinetics/chain/kinetics[17]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[17]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[17]/Ras/dephosph-GAP /kinetics/chain/kinetics[17]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[17]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[17]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[16]/Ras/GAP/diff /kinetics/chain/kinetics[17]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[17]/Ras/GAP/diff /kinetics/chain/kinetics[17]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/GTP-Ras /kinetics/chain/kinetics[17]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/GAP /kinetics/chain/kinetics[17]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[17]/Ras/GAP /kinetics/chain/kinetics[17]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/GAP /kinetics/chain/kinetics[17]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF /kinetics/chain/kinetics[17]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/CaM-GEF /kinetics/chain/kinetics[17]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 /kinetics/chain/kinetics[17]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[17]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[17]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[17]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[16]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[17]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[17]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[17]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/GDP-Ras /kinetics/chain/kinetics[17]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/CaM-GEF /kinetics/chain/kinetics[17]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[17]/Ras/CaM-GEF /kinetics/chain/kinetics[17]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/CaM-GEF /kinetics/chain/kinetics[17]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[17]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM/diff /kinetics/chain/kinetics[17]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[17]/CaM/CaM/diff /kinetics/chain/kinetics[17]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM /kinetics/chain/kinetics[17]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM /kinetics/chain/kinetics[17]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca3 /kinetics/chain/kinetics[17]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 /kinetics/chain/kinetics[17]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[17]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[17]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca3 /kinetics/chain/kinetics[17]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca3 /kinetics/chain/kinetics[17]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[17]/PKM/trigger_PKM /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 /kinetics/chain/kinetics[17]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca4 /kinetics/chain/kinetics[17]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/CaM/CaM /kinetics/chain/kinetics[17]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca /kinetics/chain/kinetics[17]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ca /kinetics/chain/kinetics[17]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[17]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[17]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca2 /kinetics/chain/kinetics[17]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca2 /kinetics/chain/kinetics[17]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca3 /kinetics/chain/kinetics[17]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca2 /kinetics/chain/kinetics[17]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca2 /kinetics/chain/kinetics[17]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[17]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[17]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[17]/Ca REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[17]/Ca REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[17]/Ca REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[17]/Ca REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[17]/Ca REAC A B addmsg /kinetics/chain/kinetics[17]/Ca_diff /kinetics/chain/kinetics[17]/Ca REAC B A addmsg /kinetics/chain/kinetics[16]/Ca/diff /kinetics/chain/kinetics[17]/Ca REAC B A addmsg /kinetics/chain/kinetics[17]/Ca/diff /kinetics/chain/kinetics[17]/Ca REAC A B addmsg /kinetics/chain/kinetics[17]/Ca /kinetics/chain/kinetics[17]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ca /kinetics/chain/kinetics[17]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1 /kinetics/chain/kinetics[17]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[17]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ras/GTP-Ras /kinetics/chain/kinetics[17]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKM/trigger_PKM /kinetics/chain/kinetics[17]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[16]/PKM/Ca_detector/diff /kinetics/chain/kinetics[17]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[17]/PKM/Ca_detector/diff /kinetics/chain/kinetics[17]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[17]/PKM/Ca_detector /kinetics/chain/kinetics[17]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKM/Ca_detector /kinetics/chain/kinetics[17]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[17]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[17]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[17]/PKM/turn_off_activator /kinetics/chain/kinetics[17]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[16]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[17]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[17]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[17]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[17]/PKM/PKM_synthesis /kinetics/chain/kinetics[17]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[17]/PKM/AA_pool /kinetics/chain/kinetics[17]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKM/PKM_synthesis /kinetics/chain/kinetics[17]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKM/PKM_synthesis /kinetics/chain/kinetics[17]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[17]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[17]/PKC/PKM-zeta /kinetics/chain/kinetics[17]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKM/degraded_PKM /kinetics/chain/kinetics[17]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKM/PKM_degradation /kinetics/chain/kinetics[17]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[17]/PKM/trigger_PKM /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[17]/PKM/PKM_activator /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[17]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[17]/PKM/turn_off_activator /kinetics/chain/kinetics[17]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[16]/PKM/PKM_activator/diff /kinetics/chain/kinetics[17]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[17]/PKM/PKM_activator/diff /kinetics/chain/kinetics[17]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[17]/PKM/PKM_activator /kinetics/chain/kinetics[17]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKM/PKM_activator /kinetics/chain/kinetics[17]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKM/PKM_synthesis /kinetics/chain/kinetics[17]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKM/PKM_activator /kinetics/chain/kinetics[17]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 /kinetics/chain/kinetics[17]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKM/Ca_detector /kinetics/chain/kinetics[17]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex /kinetics/chain/kinetics[17]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ca_diff /kinetics/chain/kinetics[17]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[17]/Ca /kinetics/chain/kinetics[17]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ca_input /kinetics/chain/kinetics[17]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[18]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[18]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[18]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[18]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[18]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca /kinetics/chain/kinetics[18]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca /kinetics/chain/kinetics[18]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ca /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca /kinetics/chain/kinetics[18]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[18]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[18]/DAG /kinetics/chain/kinetics[18]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca /kinetics/chain/kinetics[18]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[18]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[18]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[18]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/DAG /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG /kinetics/chain/kinetics[18]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[18]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[18]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG /kinetics/chain/kinetics[18]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG /kinetics/chain/kinetics[18]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[18]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[18]/PKM/PKM_degradation /kinetics/chain/kinetics[18]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[18]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[18]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKM-zeta /kinetics/chain/kinetics[18]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKM-zeta /kinetics/chain/kinetics[18]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[18]/DAG REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG /kinetics/chain/kinetics[18]/DAG REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[18]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[18]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[18]/PKC/PKM-zeta /kinetics/chain/kinetics[18]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[18]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[18]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[18]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[18]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[18]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[18]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[18]/PKC-active /kinetics/chain/kinetics[18]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1 /kinetics/chain/kinetics[18]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC-active /kinetics/chain/kinetics[18]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[18]/Ras/GAP /kinetics/chain/kinetics[18]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC-active /kinetics/chain/kinetics[18]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF /kinetics/chain/kinetics[18]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[18]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[18]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[18]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[17]/MAPK*/diff /kinetics/chain/kinetics[18]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[18]/MAPK*/diff /kinetics/chain/kinetics[18]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[18]/MAPK* /kinetics/chain/kinetics[18]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1* /kinetics/chain/kinetics[18]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK* /kinetics/chain/kinetics[18]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK* /kinetics/chain/kinetics[18]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[18]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[18]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[18]/Ras-act-unphosph-raf /kinetics/chain/kinetics[18]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[18]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[18]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[18]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[18]/Ras-act-craf /kinetics/chain/kinetics[18]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[18]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[18]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[18]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[18]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[18]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[18]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[18]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[18]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK/diff /kinetics/chain/kinetics[18]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK/diff /kinetics/chain/kinetics[18]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK /kinetics/chain/kinetics[18]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK /kinetics/chain/kinetics[18]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[18]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[18]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[18]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[18]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[18]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[18]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[18]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[18]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[18]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK* /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK* /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[18]/Ras-act-unphosph-raf /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[18]/Ras-act-craf /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[18]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[18]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[18]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[18]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[17]/MKP-1/diff /kinetics/chain/kinetics[18]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[18]/MKP-1/diff /kinetics/chain/kinetics[18]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr /kinetics/chain/kinetics[18]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MKP-1 /kinetics/chain/kinetics[18]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK* /kinetics/chain/kinetics[18]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MKP-1 /kinetics/chain/kinetics[18]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[18]/MKP-1 /kinetics/chain/kinetics[18]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MKP-1 /kinetics/chain/kinetics[18]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1* /kinetics/chain/kinetics[18]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[18]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ras/GTP-Ras /kinetics/chain/kinetics[18]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[18]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[18]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[18]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[18]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/diff /kinetics/chain/kinetics[18]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/diff /kinetics/chain/kinetics[18]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1* /kinetics/chain/kinetics[18]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A /kinetics/chain/kinetics[18]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK* /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1** /kinetics/chain/kinetics[18]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A /kinetics/chain/kinetics[18]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A /kinetics/chain/kinetics[18]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A /kinetics/chain/kinetics[18]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF /kinetics/chain/kinetics[18]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ras/GEF* /kinetics/chain/kinetics[18]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[18]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[18]/Ras/dephosph-GEF /kinetics/chain/kinetics[18]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[18]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[18]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[18]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF/diff /kinetics/chain/kinetics[18]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF/diff /kinetics/chain/kinetics[18]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF /kinetics/chain/kinetics[18]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[18]/Ras/GDP-Ras /kinetics/chain/kinetics[18]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF /kinetics/chain/kinetics[18]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF /kinetics/chain/kinetics[18]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[18]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[18]/Ras/dephosph-GEF /kinetics/chain/kinetics[18]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[18]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[17]/Ras/GEF*/diff /kinetics/chain/kinetics[18]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[18]/Ras/GEF*/diff /kinetics/chain/kinetics[18]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/GEF* /kinetics/chain/kinetics[18]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[18]/Ras/GDP-Ras /kinetics/chain/kinetics[18]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/GEF* /kinetics/chain/kinetics[18]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/GEF* /kinetics/chain/kinetics[18]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ras-act-craf /kinetics/chain/kinetics[18]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[18]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[18]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[18]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[18]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[18]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[18]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[18]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[18]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[18]/Ras-act-unphosph-raf /kinetics/chain/kinetics[18]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[18]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[18]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[18]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[18]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[18]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[18]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[18]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[18]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[18]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[18]/Ras/GTP-Ras /kinetics/chain/kinetics[18]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/GDP-Ras /kinetics/chain/kinetics[18]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ras/GAP* /kinetics/chain/kinetics[18]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/GAP /kinetics/chain/kinetics[18]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[18]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[18]/Ras/dephosph-GAP /kinetics/chain/kinetics[18]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/GAP*/diff /kinetics/chain/kinetics[18]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[18]/Ras/GAP*/diff /kinetics/chain/kinetics[18]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/GAP* /kinetics/chain/kinetics[18]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/GAP* /kinetics/chain/kinetics[18]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[18]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[18]/Ras/dephosph-GAP /kinetics/chain/kinetics[18]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[18]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[18]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[17]/Ras/GAP/diff /kinetics/chain/kinetics[18]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[18]/Ras/GAP/diff /kinetics/chain/kinetics[18]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/GTP-Ras /kinetics/chain/kinetics[18]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/GAP /kinetics/chain/kinetics[18]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[18]/Ras/GAP /kinetics/chain/kinetics[18]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/GAP /kinetics/chain/kinetics[18]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF /kinetics/chain/kinetics[18]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/CaM-GEF /kinetics/chain/kinetics[18]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca4 /kinetics/chain/kinetics[18]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[18]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[18]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[18]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[17]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[18]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[18]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[18]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/GDP-Ras /kinetics/chain/kinetics[18]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/CaM-GEF /kinetics/chain/kinetics[18]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[18]/Ras/CaM-GEF /kinetics/chain/kinetics[18]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/CaM-GEF /kinetics/chain/kinetics[18]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[18]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM/diff /kinetics/chain/kinetics[18]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[18]/CaM/CaM/diff /kinetics/chain/kinetics[18]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM /kinetics/chain/kinetics[18]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM /kinetics/chain/kinetics[18]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca3 /kinetics/chain/kinetics[18]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca4 /kinetics/chain/kinetics[18]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[18]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[18]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca3 /kinetics/chain/kinetics[18]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca3 /kinetics/chain/kinetics[18]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[18]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[18]/PKM/trigger_PKM /kinetics/chain/kinetics[18]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[18]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[18]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca4 /kinetics/chain/kinetics[18]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 /kinetics/chain/kinetics[18]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/CaM/CaM /kinetics/chain/kinetics[18]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca /kinetics/chain/kinetics[18]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ca /kinetics/chain/kinetics[18]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[18]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[18]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca2 /kinetics/chain/kinetics[18]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca2 /kinetics/chain/kinetics[18]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca3 /kinetics/chain/kinetics[18]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca2 /kinetics/chain/kinetics[18]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca2 /kinetics/chain/kinetics[18]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[18]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[18]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[18]/Ca REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[18]/Ca REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[18]/Ca REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[18]/Ca REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[18]/Ca REAC A B addmsg /kinetics/chain/kinetics[18]/Ca_diff /kinetics/chain/kinetics[18]/Ca REAC B A addmsg /kinetics/chain/kinetics[17]/Ca/diff /kinetics/chain/kinetics[18]/Ca REAC B A addmsg /kinetics/chain/kinetics[18]/Ca/diff /kinetics/chain/kinetics[18]/Ca REAC A B addmsg /kinetics/chain/kinetics[18]/Ca /kinetics/chain/kinetics[18]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ca /kinetics/chain/kinetics[18]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1 /kinetics/chain/kinetics[18]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[18]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ras/GTP-Ras /kinetics/chain/kinetics[18]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKM/trigger_PKM /kinetics/chain/kinetics[18]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[17]/PKM/Ca_detector/diff /kinetics/chain/kinetics[18]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[18]/PKM/Ca_detector/diff /kinetics/chain/kinetics[18]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[18]/PKM/Ca_detector /kinetics/chain/kinetics[18]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKM/Ca_detector /kinetics/chain/kinetics[18]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[18]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[18]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[18]/PKM/turn_off_activator /kinetics/chain/kinetics[18]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[17]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[18]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[18]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[18]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[18]/PKM/PKM_synthesis /kinetics/chain/kinetics[18]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[18]/PKM/AA_pool /kinetics/chain/kinetics[18]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKM/PKM_synthesis /kinetics/chain/kinetics[18]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKM/PKM_synthesis /kinetics/chain/kinetics[18]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[18]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[18]/PKC/PKM-zeta /kinetics/chain/kinetics[18]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKM/degraded_PKM /kinetics/chain/kinetics[18]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKM/PKM_degradation /kinetics/chain/kinetics[18]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[18]/PKM/trigger_PKM /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[18]/PKM/PKM_activator /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[18]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[18]/PKM/turn_off_activator /kinetics/chain/kinetics[18]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[17]/PKM/PKM_activator/diff /kinetics/chain/kinetics[18]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[18]/PKM/PKM_activator/diff /kinetics/chain/kinetics[18]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[18]/PKM/PKM_activator /kinetics/chain/kinetics[18]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKM/PKM_activator /kinetics/chain/kinetics[18]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKM/PKM_synthesis /kinetics/chain/kinetics[18]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKM/PKM_activator /kinetics/chain/kinetics[18]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca4 /kinetics/chain/kinetics[18]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKM/Ca_detector /kinetics/chain/kinetics[18]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex /kinetics/chain/kinetics[18]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ca_diff /kinetics/chain/kinetics[18]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[18]/Ca /kinetics/chain/kinetics[18]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ca_input /kinetics/chain/kinetics[18]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[19]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[19]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[19]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[19]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[19]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca /kinetics/chain/kinetics[19]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca /kinetics/chain/kinetics[19]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ca /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca /kinetics/chain/kinetics[19]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[19]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[19]/DAG /kinetics/chain/kinetics[19]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca /kinetics/chain/kinetics[19]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[19]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[19]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[19]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/DAG /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG /kinetics/chain/kinetics[19]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[19]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[19]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG /kinetics/chain/kinetics[19]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG /kinetics/chain/kinetics[19]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[19]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[19]/PKM/PKM_degradation /kinetics/chain/kinetics[19]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[19]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[19]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKM-zeta /kinetics/chain/kinetics[19]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKM-zeta /kinetics/chain/kinetics[19]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[19]/DAG REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG /kinetics/chain/kinetics[19]/DAG REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[19]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[19]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[19]/PKC/PKM-zeta /kinetics/chain/kinetics[19]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[19]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[19]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[19]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[19]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[19]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[19]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[19]/PKC-active /kinetics/chain/kinetics[19]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1 /kinetics/chain/kinetics[19]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC-active /kinetics/chain/kinetics[19]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[19]/Ras/GAP /kinetics/chain/kinetics[19]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC-active /kinetics/chain/kinetics[19]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF /kinetics/chain/kinetics[19]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[19]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[19]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[19]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[18]/MAPK*/diff /kinetics/chain/kinetics[19]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[19]/MAPK*/diff /kinetics/chain/kinetics[19]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[19]/MAPK* /kinetics/chain/kinetics[19]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1* /kinetics/chain/kinetics[19]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK* /kinetics/chain/kinetics[19]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK* /kinetics/chain/kinetics[19]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[19]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[19]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[19]/Ras-act-unphosph-raf /kinetics/chain/kinetics[19]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[19]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[19]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[19]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[19]/Ras-act-craf /kinetics/chain/kinetics[19]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[19]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[19]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[19]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[19]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[19]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[19]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[19]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[19]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK/diff /kinetics/chain/kinetics[19]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK/diff /kinetics/chain/kinetics[19]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK /kinetics/chain/kinetics[19]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK /kinetics/chain/kinetics[19]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[19]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[19]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[19]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[19]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[19]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[19]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[19]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[19]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[19]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK* /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK* /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[19]/Ras-act-unphosph-raf /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[19]/Ras-act-craf /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[19]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[19]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[19]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[19]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[18]/MKP-1/diff /kinetics/chain/kinetics[19]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[19]/MKP-1/diff /kinetics/chain/kinetics[19]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr /kinetics/chain/kinetics[19]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MKP-1 /kinetics/chain/kinetics[19]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK* /kinetics/chain/kinetics[19]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MKP-1 /kinetics/chain/kinetics[19]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[19]/MKP-1 /kinetics/chain/kinetics[19]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MKP-1 /kinetics/chain/kinetics[19]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1* /kinetics/chain/kinetics[19]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[19]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ras/GTP-Ras /kinetics/chain/kinetics[19]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[19]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[19]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[19]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[19]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/diff /kinetics/chain/kinetics[19]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/diff /kinetics/chain/kinetics[19]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1* /kinetics/chain/kinetics[19]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A /kinetics/chain/kinetics[19]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK* /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1** /kinetics/chain/kinetics[19]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A /kinetics/chain/kinetics[19]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A /kinetics/chain/kinetics[19]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A /kinetics/chain/kinetics[19]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF /kinetics/chain/kinetics[19]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ras/GEF* /kinetics/chain/kinetics[19]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[19]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[19]/Ras/dephosph-GEF /kinetics/chain/kinetics[19]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[19]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[19]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[19]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF/diff /kinetics/chain/kinetics[19]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF/diff /kinetics/chain/kinetics[19]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF /kinetics/chain/kinetics[19]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[19]/Ras/GDP-Ras /kinetics/chain/kinetics[19]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF /kinetics/chain/kinetics[19]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF /kinetics/chain/kinetics[19]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[19]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[19]/Ras/dephosph-GEF /kinetics/chain/kinetics[19]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[19]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[18]/Ras/GEF*/diff /kinetics/chain/kinetics[19]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[19]/Ras/GEF*/diff /kinetics/chain/kinetics[19]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/GEF* /kinetics/chain/kinetics[19]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[19]/Ras/GDP-Ras /kinetics/chain/kinetics[19]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/GEF* /kinetics/chain/kinetics[19]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/GEF* /kinetics/chain/kinetics[19]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ras-act-craf /kinetics/chain/kinetics[19]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[19]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[19]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[19]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[19]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[19]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[19]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[19]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[19]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[19]/Ras-act-unphosph-raf /kinetics/chain/kinetics[19]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[19]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[19]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[19]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[19]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[19]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[19]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[19]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[19]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[19]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[19]/Ras/GTP-Ras /kinetics/chain/kinetics[19]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/GDP-Ras /kinetics/chain/kinetics[19]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ras/GAP* /kinetics/chain/kinetics[19]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/GAP /kinetics/chain/kinetics[19]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[19]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[19]/Ras/dephosph-GAP /kinetics/chain/kinetics[19]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/GAP*/diff /kinetics/chain/kinetics[19]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[19]/Ras/GAP*/diff /kinetics/chain/kinetics[19]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/GAP* /kinetics/chain/kinetics[19]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/GAP* /kinetics/chain/kinetics[19]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[19]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[19]/Ras/dephosph-GAP /kinetics/chain/kinetics[19]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[19]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[19]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[18]/Ras/GAP/diff /kinetics/chain/kinetics[19]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[19]/Ras/GAP/diff /kinetics/chain/kinetics[19]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/GTP-Ras /kinetics/chain/kinetics[19]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/GAP /kinetics/chain/kinetics[19]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[19]/Ras/GAP /kinetics/chain/kinetics[19]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/GAP /kinetics/chain/kinetics[19]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF /kinetics/chain/kinetics[19]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/CaM-GEF /kinetics/chain/kinetics[19]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 /kinetics/chain/kinetics[19]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[19]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[19]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[19]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[18]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[19]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[19]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[19]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/GDP-Ras /kinetics/chain/kinetics[19]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/CaM-GEF /kinetics/chain/kinetics[19]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[19]/Ras/CaM-GEF /kinetics/chain/kinetics[19]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/CaM-GEF /kinetics/chain/kinetics[19]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[19]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM/diff /kinetics/chain/kinetics[19]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[19]/CaM/CaM/diff /kinetics/chain/kinetics[19]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM /kinetics/chain/kinetics[19]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM /kinetics/chain/kinetics[19]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca3 /kinetics/chain/kinetics[19]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 /kinetics/chain/kinetics[19]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[19]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[19]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca3 /kinetics/chain/kinetics[19]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca3 /kinetics/chain/kinetics[19]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[19]/PKM/trigger_PKM /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 /kinetics/chain/kinetics[19]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 /kinetics/chain/kinetics[19]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/CaM/CaM /kinetics/chain/kinetics[19]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca /kinetics/chain/kinetics[19]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ca /kinetics/chain/kinetics[19]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[19]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[19]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca2 /kinetics/chain/kinetics[19]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca2 /kinetics/chain/kinetics[19]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca3 /kinetics/chain/kinetics[19]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca2 /kinetics/chain/kinetics[19]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca2 /kinetics/chain/kinetics[19]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[19]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[19]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[19]/Ca REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[19]/Ca REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[19]/Ca REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[19]/Ca REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[19]/Ca REAC A B addmsg /kinetics/chain/kinetics[19]/Ca_diff /kinetics/chain/kinetics[19]/Ca REAC B A addmsg /kinetics/chain/kinetics[18]/Ca/diff /kinetics/chain/kinetics[19]/Ca REAC B A addmsg /kinetics/chain/kinetics[19]/Ca/diff /kinetics/chain/kinetics[19]/Ca REAC A B addmsg /kinetics/chain/kinetics[19]/Ca /kinetics/chain/kinetics[19]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ca /kinetics/chain/kinetics[19]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1 /kinetics/chain/kinetics[19]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[19]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ras/GTP-Ras /kinetics/chain/kinetics[19]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKM/trigger_PKM /kinetics/chain/kinetics[19]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[18]/PKM/Ca_detector/diff /kinetics/chain/kinetics[19]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[19]/PKM/Ca_detector/diff /kinetics/chain/kinetics[19]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[19]/PKM/Ca_detector /kinetics/chain/kinetics[19]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKM/Ca_detector /kinetics/chain/kinetics[19]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[19]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[19]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[19]/PKM/turn_off_activator /kinetics/chain/kinetics[19]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[18]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[19]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[19]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[19]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[19]/PKM/PKM_synthesis /kinetics/chain/kinetics[19]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[19]/PKM/AA_pool /kinetics/chain/kinetics[19]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKM/PKM_synthesis /kinetics/chain/kinetics[19]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKM/PKM_synthesis /kinetics/chain/kinetics[19]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[19]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[19]/PKC/PKM-zeta /kinetics/chain/kinetics[19]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKM/degraded_PKM /kinetics/chain/kinetics[19]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKM/PKM_degradation /kinetics/chain/kinetics[19]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[19]/PKM/trigger_PKM /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[19]/PKM/PKM_activator /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[19]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[19]/PKM/turn_off_activator /kinetics/chain/kinetics[19]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[18]/PKM/PKM_activator/diff /kinetics/chain/kinetics[19]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[19]/PKM/PKM_activator/diff /kinetics/chain/kinetics[19]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[19]/PKM/PKM_activator /kinetics/chain/kinetics[19]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKM/PKM_activator /kinetics/chain/kinetics[19]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKM/PKM_synthesis /kinetics/chain/kinetics[19]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKM/PKM_activator /kinetics/chain/kinetics[19]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 /kinetics/chain/kinetics[19]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKM/Ca_detector /kinetics/chain/kinetics[19]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex /kinetics/chain/kinetics[19]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ca_diff /kinetics/chain/kinetics[19]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[19]/Ca /kinetics/chain/kinetics[19]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ca_input /kinetics/chain/kinetics[19]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[20]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[20]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[20]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[20]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[20]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca /kinetics/chain/kinetics[20]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca /kinetics/chain/kinetics[20]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ca /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[20]/DAG /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca /kinetics/chain/kinetics[20]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[20]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[20]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[20]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/DAG /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG /kinetics/chain/kinetics[20]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[20]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[20]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG /kinetics/chain/kinetics[20]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG /kinetics/chain/kinetics[20]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[20]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[20]/PKM/PKM_degradation /kinetics/chain/kinetics[20]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[20]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[20]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKM-zeta /kinetics/chain/kinetics[20]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKM-zeta /kinetics/chain/kinetics[20]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[20]/DAG REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG /kinetics/chain/kinetics[20]/DAG REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[20]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[20]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[20]/PKC/PKM-zeta /kinetics/chain/kinetics[20]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[20]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[20]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[20]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[20]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[20]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[20]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[20]/PKC-active /kinetics/chain/kinetics[20]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1 /kinetics/chain/kinetics[20]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC-active /kinetics/chain/kinetics[20]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[20]/Ras/GAP /kinetics/chain/kinetics[20]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC-active /kinetics/chain/kinetics[20]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF /kinetics/chain/kinetics[20]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[20]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[20]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[20]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[19]/MAPK*/diff /kinetics/chain/kinetics[20]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[20]/MAPK*/diff /kinetics/chain/kinetics[20]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[20]/MAPK* /kinetics/chain/kinetics[20]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1* /kinetics/chain/kinetics[20]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK* /kinetics/chain/kinetics[20]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK* /kinetics/chain/kinetics[20]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[20]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[20]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[20]/Ras-act-unphosph-raf /kinetics/chain/kinetics[20]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[20]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[20]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[20]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[20]/Ras-act-craf /kinetics/chain/kinetics[20]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[20]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[20]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[20]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[20]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[20]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[20]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[20]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[20]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK/diff /kinetics/chain/kinetics[20]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK/diff /kinetics/chain/kinetics[20]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK /kinetics/chain/kinetics[20]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK /kinetics/chain/kinetics[20]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[20]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[20]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[20]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[20]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[20]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[20]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[20]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[20]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[20]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK* /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK* /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[20]/Ras-act-unphosph-raf /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[20]/Ras-act-craf /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[20]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[20]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[20]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[20]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[19]/MKP-1/diff /kinetics/chain/kinetics[20]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[20]/MKP-1/diff /kinetics/chain/kinetics[20]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr /kinetics/chain/kinetics[20]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MKP-1 /kinetics/chain/kinetics[20]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK* /kinetics/chain/kinetics[20]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MKP-1 /kinetics/chain/kinetics[20]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[20]/MKP-1 /kinetics/chain/kinetics[20]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MKP-1 /kinetics/chain/kinetics[20]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1* /kinetics/chain/kinetics[20]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[20]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ras/GTP-Ras /kinetics/chain/kinetics[20]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[20]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[20]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[20]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[20]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/diff /kinetics/chain/kinetics[20]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/diff /kinetics/chain/kinetics[20]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1* /kinetics/chain/kinetics[20]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A /kinetics/chain/kinetics[20]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK* /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1** /kinetics/chain/kinetics[20]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A /kinetics/chain/kinetics[20]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A /kinetics/chain/kinetics[20]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A /kinetics/chain/kinetics[20]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF /kinetics/chain/kinetics[20]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ras/GEF* /kinetics/chain/kinetics[20]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[20]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[20]/Ras/dephosph-GEF /kinetics/chain/kinetics[20]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[20]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[20]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[20]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF/diff /kinetics/chain/kinetics[20]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF/diff /kinetics/chain/kinetics[20]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF /kinetics/chain/kinetics[20]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[20]/Ras/GDP-Ras /kinetics/chain/kinetics[20]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF /kinetics/chain/kinetics[20]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF /kinetics/chain/kinetics[20]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[20]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[20]/Ras/dephosph-GEF /kinetics/chain/kinetics[20]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[20]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[19]/Ras/GEF*/diff /kinetics/chain/kinetics[20]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[20]/Ras/GEF*/diff /kinetics/chain/kinetics[20]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/GEF* /kinetics/chain/kinetics[20]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[20]/Ras/GDP-Ras /kinetics/chain/kinetics[20]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/GEF* /kinetics/chain/kinetics[20]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/GEF* /kinetics/chain/kinetics[20]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ras-act-craf /kinetics/chain/kinetics[20]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[20]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[20]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[20]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[20]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[20]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[20]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[20]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[20]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[20]/Ras-act-unphosph-raf /kinetics/chain/kinetics[20]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[20]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[20]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[20]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[20]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[20]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[20]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[20]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[20]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[20]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[20]/Ras/GTP-Ras /kinetics/chain/kinetics[20]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/GDP-Ras /kinetics/chain/kinetics[20]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ras/GAP* /kinetics/chain/kinetics[20]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/GAP /kinetics/chain/kinetics[20]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[20]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[20]/Ras/dephosph-GAP /kinetics/chain/kinetics[20]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/GAP*/diff /kinetics/chain/kinetics[20]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[20]/Ras/GAP*/diff /kinetics/chain/kinetics[20]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/GAP* /kinetics/chain/kinetics[20]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/GAP* /kinetics/chain/kinetics[20]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[20]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[20]/Ras/dephosph-GAP /kinetics/chain/kinetics[20]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[20]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[20]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[19]/Ras/GAP/diff /kinetics/chain/kinetics[20]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[20]/Ras/GAP/diff /kinetics/chain/kinetics[20]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/GTP-Ras /kinetics/chain/kinetics[20]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/GAP /kinetics/chain/kinetics[20]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[20]/Ras/GAP /kinetics/chain/kinetics[20]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/GAP /kinetics/chain/kinetics[20]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF /kinetics/chain/kinetics[20]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/CaM-GEF /kinetics/chain/kinetics[20]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 /kinetics/chain/kinetics[20]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[20]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[20]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[20]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[19]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[20]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[20]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[20]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/GDP-Ras /kinetics/chain/kinetics[20]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/CaM-GEF /kinetics/chain/kinetics[20]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[20]/Ras/CaM-GEF /kinetics/chain/kinetics[20]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/CaM-GEF /kinetics/chain/kinetics[20]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[20]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM/diff /kinetics/chain/kinetics[20]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[20]/CaM/CaM/diff /kinetics/chain/kinetics[20]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM /kinetics/chain/kinetics[20]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM /kinetics/chain/kinetics[20]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca3 /kinetics/chain/kinetics[20]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 /kinetics/chain/kinetics[20]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[20]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[20]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca3 /kinetics/chain/kinetics[20]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca3 /kinetics/chain/kinetics[20]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[20]/PKM/trigger_PKM /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 /kinetics/chain/kinetics[20]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca4 /kinetics/chain/kinetics[20]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/CaM/CaM /kinetics/chain/kinetics[20]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca /kinetics/chain/kinetics[20]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ca /kinetics/chain/kinetics[20]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[20]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[20]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca2 /kinetics/chain/kinetics[20]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca2 /kinetics/chain/kinetics[20]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca3 /kinetics/chain/kinetics[20]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca2 /kinetics/chain/kinetics[20]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca2 /kinetics/chain/kinetics[20]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[20]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[20]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[20]/Ca REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[20]/Ca REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[20]/Ca REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[20]/Ca REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[20]/Ca REAC A B addmsg /kinetics/chain/kinetics[20]/Ca_diff /kinetics/chain/kinetics[20]/Ca REAC B A addmsg /kinetics/chain/kinetics[19]/Ca/diff /kinetics/chain/kinetics[20]/Ca REAC B A addmsg /kinetics/chain/kinetics[20]/Ca/diff /kinetics/chain/kinetics[20]/Ca REAC A B addmsg /kinetics/chain/kinetics[20]/Ca /kinetics/chain/kinetics[20]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ca /kinetics/chain/kinetics[20]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1 /kinetics/chain/kinetics[20]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[20]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ras/GTP-Ras /kinetics/chain/kinetics[20]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKM/trigger_PKM /kinetics/chain/kinetics[20]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[19]/PKM/Ca_detector/diff /kinetics/chain/kinetics[20]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[20]/PKM/Ca_detector/diff /kinetics/chain/kinetics[20]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[20]/PKM/Ca_detector /kinetics/chain/kinetics[20]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKM/Ca_detector /kinetics/chain/kinetics[20]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[20]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[20]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[20]/PKM/turn_off_activator /kinetics/chain/kinetics[20]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[19]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[20]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[20]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[20]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[20]/PKM/PKM_synthesis /kinetics/chain/kinetics[20]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[20]/PKM/AA_pool /kinetics/chain/kinetics[20]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKM/PKM_synthesis /kinetics/chain/kinetics[20]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKM/PKM_synthesis /kinetics/chain/kinetics[20]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[20]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[20]/PKC/PKM-zeta /kinetics/chain/kinetics[20]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKM/degraded_PKM /kinetics/chain/kinetics[20]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKM/PKM_degradation /kinetics/chain/kinetics[20]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[20]/PKM/trigger_PKM /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[20]/PKM/PKM_activator /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[20]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[20]/PKM/turn_off_activator /kinetics/chain/kinetics[20]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[19]/PKM/PKM_activator/diff /kinetics/chain/kinetics[20]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[20]/PKM/PKM_activator/diff /kinetics/chain/kinetics[20]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[20]/PKM/PKM_activator /kinetics/chain/kinetics[20]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKM/PKM_activator /kinetics/chain/kinetics[20]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKM/PKM_synthesis /kinetics/chain/kinetics[20]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKM/PKM_activator /kinetics/chain/kinetics[20]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 /kinetics/chain/kinetics[20]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKM/Ca_detector /kinetics/chain/kinetics[20]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex /kinetics/chain/kinetics[20]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ca_diff /kinetics/chain/kinetics[20]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[20]/Ca /kinetics/chain/kinetics[20]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ca_input /kinetics/chain/kinetics[20]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[21]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[21]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[21]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[21]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[21]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca /kinetics/chain/kinetics[21]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca /kinetics/chain/kinetics[21]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ca /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca /kinetics/chain/kinetics[21]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[21]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[21]/DAG /kinetics/chain/kinetics[21]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca /kinetics/chain/kinetics[21]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[21]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[21]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[21]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/DAG /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG /kinetics/chain/kinetics[21]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[21]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[21]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG /kinetics/chain/kinetics[21]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG /kinetics/chain/kinetics[21]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[21]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[21]/PKM/PKM_degradation /kinetics/chain/kinetics[21]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[21]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[21]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKM-zeta /kinetics/chain/kinetics[21]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKM-zeta /kinetics/chain/kinetics[21]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[21]/DAG REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG /kinetics/chain/kinetics[21]/DAG REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[21]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[21]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[21]/PKC/PKM-zeta /kinetics/chain/kinetics[21]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[21]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[21]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[21]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[21]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[21]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[21]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[21]/PKC-active /kinetics/chain/kinetics[21]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1 /kinetics/chain/kinetics[21]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC-active /kinetics/chain/kinetics[21]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[21]/Ras/GAP /kinetics/chain/kinetics[21]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC-active /kinetics/chain/kinetics[21]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF /kinetics/chain/kinetics[21]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[21]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[21]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[21]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[20]/MAPK*/diff /kinetics/chain/kinetics[21]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[21]/MAPK*/diff /kinetics/chain/kinetics[21]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[21]/MAPK* /kinetics/chain/kinetics[21]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1* /kinetics/chain/kinetics[21]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK* /kinetics/chain/kinetics[21]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK* /kinetics/chain/kinetics[21]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[21]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[21]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[21]/Ras-act-unphosph-raf /kinetics/chain/kinetics[21]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[21]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[21]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[21]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[21]/Ras-act-craf /kinetics/chain/kinetics[21]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[21]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[21]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[21]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[21]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[21]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[21]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[21]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[21]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK/diff /kinetics/chain/kinetics[21]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK/diff /kinetics/chain/kinetics[21]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK /kinetics/chain/kinetics[21]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK /kinetics/chain/kinetics[21]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[21]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[21]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[21]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[21]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[21]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[21]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[21]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[21]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[21]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK* /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK* /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[21]/Ras-act-unphosph-raf /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[21]/Ras-act-craf /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[21]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[21]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[21]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[21]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[20]/MKP-1/diff /kinetics/chain/kinetics[21]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[21]/MKP-1/diff /kinetics/chain/kinetics[21]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr /kinetics/chain/kinetics[21]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MKP-1 /kinetics/chain/kinetics[21]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK* /kinetics/chain/kinetics[21]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MKP-1 /kinetics/chain/kinetics[21]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[21]/MKP-1 /kinetics/chain/kinetics[21]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MKP-1 /kinetics/chain/kinetics[21]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1* /kinetics/chain/kinetics[21]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[21]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ras/GTP-Ras /kinetics/chain/kinetics[21]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[21]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[21]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[21]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[21]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/diff /kinetics/chain/kinetics[21]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/diff /kinetics/chain/kinetics[21]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1* /kinetics/chain/kinetics[21]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A /kinetics/chain/kinetics[21]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK* /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1** /kinetics/chain/kinetics[21]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A /kinetics/chain/kinetics[21]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A /kinetics/chain/kinetics[21]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A /kinetics/chain/kinetics[21]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF /kinetics/chain/kinetics[21]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ras/GEF* /kinetics/chain/kinetics[21]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[21]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[21]/Ras/dephosph-GEF /kinetics/chain/kinetics[21]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[21]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[21]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[21]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF/diff /kinetics/chain/kinetics[21]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF/diff /kinetics/chain/kinetics[21]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF /kinetics/chain/kinetics[21]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[21]/Ras/GDP-Ras /kinetics/chain/kinetics[21]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF /kinetics/chain/kinetics[21]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF /kinetics/chain/kinetics[21]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[21]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[21]/Ras/dephosph-GEF /kinetics/chain/kinetics[21]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[21]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[20]/Ras/GEF*/diff /kinetics/chain/kinetics[21]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[21]/Ras/GEF*/diff /kinetics/chain/kinetics[21]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/GEF* /kinetics/chain/kinetics[21]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[21]/Ras/GDP-Ras /kinetics/chain/kinetics[21]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/GEF* /kinetics/chain/kinetics[21]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/GEF* /kinetics/chain/kinetics[21]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ras-act-craf /kinetics/chain/kinetics[21]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[21]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[21]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[21]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[21]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[21]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[21]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[21]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[21]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[21]/Ras-act-unphosph-raf /kinetics/chain/kinetics[21]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[21]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[21]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[21]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[21]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[21]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[21]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[21]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[21]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[21]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[21]/Ras/GTP-Ras /kinetics/chain/kinetics[21]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/GDP-Ras /kinetics/chain/kinetics[21]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ras/GAP* /kinetics/chain/kinetics[21]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/GAP /kinetics/chain/kinetics[21]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[21]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[21]/Ras/dephosph-GAP /kinetics/chain/kinetics[21]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/GAP*/diff /kinetics/chain/kinetics[21]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[21]/Ras/GAP*/diff /kinetics/chain/kinetics[21]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/GAP* /kinetics/chain/kinetics[21]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/GAP* /kinetics/chain/kinetics[21]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[21]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[21]/Ras/dephosph-GAP /kinetics/chain/kinetics[21]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[21]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[21]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[20]/Ras/GAP/diff /kinetics/chain/kinetics[21]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[21]/Ras/GAP/diff /kinetics/chain/kinetics[21]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/GTP-Ras /kinetics/chain/kinetics[21]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/GAP /kinetics/chain/kinetics[21]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[21]/Ras/GAP /kinetics/chain/kinetics[21]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/GAP /kinetics/chain/kinetics[21]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF /kinetics/chain/kinetics[21]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/CaM-GEF /kinetics/chain/kinetics[21]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca4 /kinetics/chain/kinetics[21]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[21]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[21]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[21]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[20]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[21]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[21]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[21]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/GDP-Ras /kinetics/chain/kinetics[21]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/CaM-GEF /kinetics/chain/kinetics[21]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[21]/Ras/CaM-GEF /kinetics/chain/kinetics[21]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/CaM-GEF /kinetics/chain/kinetics[21]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[21]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM/diff /kinetics/chain/kinetics[21]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[21]/CaM/CaM/diff /kinetics/chain/kinetics[21]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM /kinetics/chain/kinetics[21]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM /kinetics/chain/kinetics[21]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca3 /kinetics/chain/kinetics[21]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca4 /kinetics/chain/kinetics[21]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[21]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[21]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca3 /kinetics/chain/kinetics[21]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca3 /kinetics/chain/kinetics[21]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[21]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[21]/PKM/trigger_PKM /kinetics/chain/kinetics[21]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[21]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[21]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca4 /kinetics/chain/kinetics[21]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca4 /kinetics/chain/kinetics[21]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/CaM/CaM /kinetics/chain/kinetics[21]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca /kinetics/chain/kinetics[21]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ca /kinetics/chain/kinetics[21]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[21]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[21]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca2 /kinetics/chain/kinetics[21]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca2 /kinetics/chain/kinetics[21]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca3 /kinetics/chain/kinetics[21]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca2 /kinetics/chain/kinetics[21]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca2 /kinetics/chain/kinetics[21]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[21]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[21]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[21]/Ca REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[21]/Ca REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[21]/Ca REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[21]/Ca REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[21]/Ca REAC A B addmsg /kinetics/chain/kinetics[21]/Ca_diff /kinetics/chain/kinetics[21]/Ca REAC B A addmsg /kinetics/chain/kinetics[20]/Ca/diff /kinetics/chain/kinetics[21]/Ca REAC B A addmsg /kinetics/chain/kinetics[21]/Ca/diff /kinetics/chain/kinetics[21]/Ca REAC A B addmsg /kinetics/chain/kinetics[21]/Ca /kinetics/chain/kinetics[21]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ca /kinetics/chain/kinetics[21]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1 /kinetics/chain/kinetics[21]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[21]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ras/GTP-Ras /kinetics/chain/kinetics[21]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKM/trigger_PKM /kinetics/chain/kinetics[21]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[20]/PKM/Ca_detector/diff /kinetics/chain/kinetics[21]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[21]/PKM/Ca_detector/diff /kinetics/chain/kinetics[21]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[21]/PKM/Ca_detector /kinetics/chain/kinetics[21]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKM/Ca_detector /kinetics/chain/kinetics[21]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[21]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[21]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[21]/PKM/turn_off_activator /kinetics/chain/kinetics[21]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[20]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[21]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[21]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[21]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[21]/PKM/PKM_synthesis /kinetics/chain/kinetics[21]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[21]/PKM/AA_pool /kinetics/chain/kinetics[21]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKM/PKM_synthesis /kinetics/chain/kinetics[21]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKM/PKM_synthesis /kinetics/chain/kinetics[21]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[21]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[21]/PKC/PKM-zeta /kinetics/chain/kinetics[21]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKM/degraded_PKM /kinetics/chain/kinetics[21]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKM/PKM_degradation /kinetics/chain/kinetics[21]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[21]/PKM/trigger_PKM /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[21]/PKM/PKM_activator /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[21]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[21]/PKM/turn_off_activator /kinetics/chain/kinetics[21]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[20]/PKM/PKM_activator/diff /kinetics/chain/kinetics[21]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[21]/PKM/PKM_activator/diff /kinetics/chain/kinetics[21]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[21]/PKM/PKM_activator /kinetics/chain/kinetics[21]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKM/PKM_activator /kinetics/chain/kinetics[21]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKM/PKM_synthesis /kinetics/chain/kinetics[21]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKM/PKM_activator /kinetics/chain/kinetics[21]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca4 /kinetics/chain/kinetics[21]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKM/Ca_detector /kinetics/chain/kinetics[21]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex /kinetics/chain/kinetics[21]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ca_diff /kinetics/chain/kinetics[21]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[21]/Ca /kinetics/chain/kinetics[21]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ca_input /kinetics/chain/kinetics[21]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[22]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[22]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[22]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[22]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[22]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca /kinetics/chain/kinetics[22]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca /kinetics/chain/kinetics[22]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ca /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca /kinetics/chain/kinetics[22]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[22]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[22]/DAG /kinetics/chain/kinetics[22]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca /kinetics/chain/kinetics[22]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[22]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[22]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[22]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/DAG /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG /kinetics/chain/kinetics[22]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[22]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[22]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG /kinetics/chain/kinetics[22]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG /kinetics/chain/kinetics[22]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[22]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[22]/PKM/PKM_degradation /kinetics/chain/kinetics[22]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[22]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[22]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKM-zeta /kinetics/chain/kinetics[22]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKM-zeta /kinetics/chain/kinetics[22]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[22]/DAG REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG /kinetics/chain/kinetics[22]/DAG REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[22]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[22]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[22]/PKC/PKM-zeta /kinetics/chain/kinetics[22]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[22]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[22]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[22]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[22]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[22]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[22]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[22]/PKC-active /kinetics/chain/kinetics[22]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1 /kinetics/chain/kinetics[22]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC-active /kinetics/chain/kinetics[22]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[22]/Ras/GAP /kinetics/chain/kinetics[22]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC-active /kinetics/chain/kinetics[22]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF /kinetics/chain/kinetics[22]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[22]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[22]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[22]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[21]/MAPK*/diff /kinetics/chain/kinetics[22]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[22]/MAPK*/diff /kinetics/chain/kinetics[22]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[22]/MAPK* /kinetics/chain/kinetics[22]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1* /kinetics/chain/kinetics[22]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK* /kinetics/chain/kinetics[22]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK* /kinetics/chain/kinetics[22]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[22]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[22]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[22]/Ras-act-unphosph-raf /kinetics/chain/kinetics[22]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[22]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[22]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[22]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[22]/Ras-act-craf /kinetics/chain/kinetics[22]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[22]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[22]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[22]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[22]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[22]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[22]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[22]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[22]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK/diff /kinetics/chain/kinetics[22]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK/diff /kinetics/chain/kinetics[22]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK /kinetics/chain/kinetics[22]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPK /kinetics/chain/kinetics[22]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[22]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[22]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[22]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[22]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[22]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[22]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[22]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[22]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[22]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK* /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK* /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[22]/Ras-act-unphosph-raf /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[22]/Ras-act-craf /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[22]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[22]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[22]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[22]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[21]/MKP-1/diff /kinetics/chain/kinetics[22]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[22]/MKP-1/diff /kinetics/chain/kinetics[22]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr /kinetics/chain/kinetics[22]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MKP-1 /kinetics/chain/kinetics[22]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK* /kinetics/chain/kinetics[22]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MKP-1 /kinetics/chain/kinetics[22]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[22]/MKP-1 /kinetics/chain/kinetics[22]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MKP-1 /kinetics/chain/kinetics[22]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1* /kinetics/chain/kinetics[22]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[22]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ras/GTP-Ras /kinetics/chain/kinetics[22]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[22]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[22]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[22]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[22]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/diff /kinetics/chain/kinetics[22]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/diff /kinetics/chain/kinetics[22]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1* /kinetics/chain/kinetics[22]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A /kinetics/chain/kinetics[22]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK* /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1** /kinetics/chain/kinetics[22]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A /kinetics/chain/kinetics[22]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A /kinetics/chain/kinetics[22]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A /kinetics/chain/kinetics[22]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF /kinetics/chain/kinetics[22]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ras/GEF* /kinetics/chain/kinetics[22]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[22]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[22]/Ras/dephosph-GEF /kinetics/chain/kinetics[22]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[22]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[22]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[22]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF/diff /kinetics/chain/kinetics[22]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF/diff /kinetics/chain/kinetics[22]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF /kinetics/chain/kinetics[22]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[22]/Ras/GDP-Ras /kinetics/chain/kinetics[22]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF /kinetics/chain/kinetics[22]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/inact-GEF /kinetics/chain/kinetics[22]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[22]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[22]/Ras/dephosph-GEF /kinetics/chain/kinetics[22]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[22]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[21]/Ras/GEF*/diff /kinetics/chain/kinetics[22]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[22]/Ras/GEF*/diff /kinetics/chain/kinetics[22]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/GEF* /kinetics/chain/kinetics[22]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[22]/Ras/GDP-Ras /kinetics/chain/kinetics[22]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/GEF* /kinetics/chain/kinetics[22]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/GEF* /kinetics/chain/kinetics[22]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ras-act-craf /kinetics/chain/kinetics[22]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[22]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[22]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[22]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[22]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[22]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[22]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[22]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[22]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[22]/Ras-act-unphosph-raf /kinetics/chain/kinetics[22]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[22]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[22]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[22]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[22]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[22]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[22]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[22]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[22]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[22]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[22]/Ras/GTP-Ras /kinetics/chain/kinetics[22]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/GDP-Ras /kinetics/chain/kinetics[22]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ras/GAP* /kinetics/chain/kinetics[22]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/GAP /kinetics/chain/kinetics[22]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[22]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[22]/Ras/dephosph-GAP /kinetics/chain/kinetics[22]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/GAP*/diff /kinetics/chain/kinetics[22]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[22]/Ras/GAP*/diff /kinetics/chain/kinetics[22]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/GAP* /kinetics/chain/kinetics[22]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/GAP* /kinetics/chain/kinetics[22]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[22]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[22]/Ras/dephosph-GAP /kinetics/chain/kinetics[22]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[22]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[22]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[21]/Ras/GAP/diff /kinetics/chain/kinetics[22]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[22]/Ras/GAP/diff /kinetics/chain/kinetics[22]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/GTP-Ras /kinetics/chain/kinetics[22]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/GAP /kinetics/chain/kinetics[22]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[22]/Ras/GAP /kinetics/chain/kinetics[22]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/GAP /kinetics/chain/kinetics[22]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF /kinetics/chain/kinetics[22]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/CaM-GEF /kinetics/chain/kinetics[22]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca4 /kinetics/chain/kinetics[22]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[22]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[22]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[22]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[21]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[22]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[22]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[22]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/GDP-Ras /kinetics/chain/kinetics[22]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/CaM-GEF /kinetics/chain/kinetics[22]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[22]/Ras/CaM-GEF /kinetics/chain/kinetics[22]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/CaM-GEF /kinetics/chain/kinetics[22]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[22]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM/diff /kinetics/chain/kinetics[22]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[22]/CaM/CaM/diff /kinetics/chain/kinetics[22]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM /kinetics/chain/kinetics[22]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM /kinetics/chain/kinetics[22]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca3 /kinetics/chain/kinetics[22]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca4 /kinetics/chain/kinetics[22]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[22]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[22]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca3 /kinetics/chain/kinetics[22]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca3 /kinetics/chain/kinetics[22]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[22]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[22]/PKM/trigger_PKM /kinetics/chain/kinetics[22]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[22]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[22]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca4 /kinetics/chain/kinetics[22]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca4 /kinetics/chain/kinetics[22]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/CaM/CaM /kinetics/chain/kinetics[22]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca /kinetics/chain/kinetics[22]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ca /kinetics/chain/kinetics[22]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[22]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[22]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca2 /kinetics/chain/kinetics[22]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca2 /kinetics/chain/kinetics[22]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca3 /kinetics/chain/kinetics[22]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca2 /kinetics/chain/kinetics[22]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca2 /kinetics/chain/kinetics[22]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[22]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[22]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[22]/Ca REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[22]/Ca REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[22]/Ca REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[22]/Ca REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[22]/Ca REAC A B addmsg /kinetics/chain/kinetics[22]/Ca_diff /kinetics/chain/kinetics[22]/Ca REAC B A addmsg /kinetics/chain/kinetics[21]/Ca/diff /kinetics/chain/kinetics[22]/Ca REAC B A addmsg /kinetics/chain/kinetics[22]/Ca/diff /kinetics/chain/kinetics[22]/Ca REAC A B addmsg /kinetics/chain/kinetics[22]/Ca /kinetics/chain/kinetics[22]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ca /kinetics/chain/kinetics[22]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1 /kinetics/chain/kinetics[22]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[22]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ras/GTP-Ras /kinetics/chain/kinetics[22]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKM/trigger_PKM /kinetics/chain/kinetics[22]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[21]/PKM/Ca_detector/diff /kinetics/chain/kinetics[22]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[22]/PKM/Ca_detector/diff /kinetics/chain/kinetics[22]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[22]/PKM/Ca_detector /kinetics/chain/kinetics[22]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKM/Ca_detector /kinetics/chain/kinetics[22]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[22]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[22]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[22]/PKM/turn_off_activator /kinetics/chain/kinetics[22]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[21]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[22]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[22]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[22]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[22]/PKM/PKM_synthesis /kinetics/chain/kinetics[22]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[22]/PKM/AA_pool /kinetics/chain/kinetics[22]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKM/PKM_synthesis /kinetics/chain/kinetics[22]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKM/PKM_synthesis /kinetics/chain/kinetics[22]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[22]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[22]/PKC/PKM-zeta /kinetics/chain/kinetics[22]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKM/degraded_PKM /kinetics/chain/kinetics[22]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKM/PKM_degradation /kinetics/chain/kinetics[22]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[22]/PKM/trigger_PKM /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[22]/PKM/PKM_activator /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[22]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[22]/PKM/turn_off_activator /kinetics/chain/kinetics[22]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[21]/PKM/PKM_activator/diff /kinetics/chain/kinetics[22]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[22]/PKM/PKM_activator/diff /kinetics/chain/kinetics[22]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[22]/PKM/PKM_activator /kinetics/chain/kinetics[22]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKM/PKM_activator /kinetics/chain/kinetics[22]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKM/PKM_synthesis /kinetics/chain/kinetics[22]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKM/PKM_activator /kinetics/chain/kinetics[22]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca4 /kinetics/chain/kinetics[22]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKM/Ca_detector /kinetics/chain/kinetics[22]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex /kinetics/chain/kinetics[22]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ca_diff /kinetics/chain/kinetics[22]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[22]/Ca /kinetics/chain/kinetics[22]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ca_input /kinetics/chain/kinetics[22]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[23]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[23]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[23]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[23]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ca /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca /kinetics/chain/kinetics[23]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[23]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[23]/DAG /kinetics/chain/kinetics[23]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca /kinetics/chain/kinetics[23]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[23]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[23]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[23]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[23]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[23]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[23]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[23]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[23]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[23]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[23]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/DAG /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG /kinetics/chain/kinetics[23]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[23]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[23]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[23]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[23]/PKM/PKM_degradation /kinetics/chain/kinetics[23]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[23]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[23]/DAG REAC A B addmsg /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG /kinetics/chain/kinetics[23]/DAG REAC A B addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[23]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[23]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[23]/PKC/PKM-zeta /kinetics/chain/kinetics[23]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[23]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[23]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[23]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[23]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[23]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[23]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[23]/PKC-active /kinetics/chain/kinetics[23]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1 /kinetics/chain/kinetics[23]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC-active /kinetics/chain/kinetics[23]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[23]/Ras/GAP /kinetics/chain/kinetics[23]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC-active /kinetics/chain/kinetics[23]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[23]/Ras/inact-GEF /kinetics/chain/kinetics[23]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[23]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[23]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[23]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[23]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[22]/MAPK*/diff /kinetics/chain/kinetics[23]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[23]/MAPK* /kinetics/chain/kinetics[23]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1* /kinetics/chain/kinetics[23]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[23]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[23]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[23]/Ras-act-unphosph-raf /kinetics/chain/kinetics[23]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[23]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[23]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[23]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[23]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[23]/Ras-act-craf /kinetics/chain/kinetics[23]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[23]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[23]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[23]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[23]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[23]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[23]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[23]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[23]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK/diff /kinetics/chain/kinetics[23]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[23]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[23]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[23]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[23]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[23]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[23]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[23]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[23]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[23]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[23]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[23]/MAPK/MAPK /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK* /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK* /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[23]/Ras-act-unphosph-raf /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[23]/Ras-act-craf /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[23]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[23]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[23]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[23]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[22]/MKP-1/diff /kinetics/chain/kinetics[23]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr /kinetics/chain/kinetics[23]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MKP-1 /kinetics/chain/kinetics[23]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK* /kinetics/chain/kinetics[23]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MKP-1 /kinetics/chain/kinetics[23]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1* /kinetics/chain/kinetics[23]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[23]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ras/GTP-Ras /kinetics/chain/kinetics[23]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[23]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[23]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[23]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[23]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/diff /kinetics/chain/kinetics[23]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1* /kinetics/chain/kinetics[23]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A /kinetics/chain/kinetics[23]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK* /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1** /kinetics/chain/kinetics[23]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A /kinetics/chain/kinetics[23]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[23]/Ras/inact-GEF /kinetics/chain/kinetics[23]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ras/GEF* /kinetics/chain/kinetics[23]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[23]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[23]/Ras/dephosph-GEF /kinetics/chain/kinetics[23]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[23]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[23]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[23]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF/diff /kinetics/chain/kinetics[23]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/inact-GEF /kinetics/chain/kinetics[23]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[23]/Ras/GDP-Ras /kinetics/chain/kinetics[23]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[23]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[23]/Ras/dephosph-GEF /kinetics/chain/kinetics[23]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[23]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[23]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[22]/Ras/GEF*/diff /kinetics/chain/kinetics[23]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/GEF* /kinetics/chain/kinetics[23]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[23]/Ras/GDP-Ras /kinetics/chain/kinetics[23]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras-act-craf /kinetics/chain/kinetics[23]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[23]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[23]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[23]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[23]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[23]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[23]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[23]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[23]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[23]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[23]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[23]/Ras-act-unphosph-raf /kinetics/chain/kinetics[23]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[23]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[23]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[23]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[23]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[23]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[23]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[23]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[23]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[23]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[23]/Ras/GTP-Ras /kinetics/chain/kinetics[23]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/GDP-Ras /kinetics/chain/kinetics[23]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ras/GAP* /kinetics/chain/kinetics[23]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/GAP /kinetics/chain/kinetics[23]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[23]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[23]/Ras/dephosph-GAP /kinetics/chain/kinetics[23]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/GAP*/diff /kinetics/chain/kinetics[23]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[23]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[23]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[23]/Ras/dephosph-GAP /kinetics/chain/kinetics[23]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[23]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[22]/Ras/GAP/diff /kinetics/chain/kinetics[23]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/GTP-Ras /kinetics/chain/kinetics[23]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/GAP /kinetics/chain/kinetics[23]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[23]/Ras/inact-GEF /kinetics/chain/kinetics[23]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/CaM-GEF /kinetics/chain/kinetics[23]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca4 /kinetics/chain/kinetics[23]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[23]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[23]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[22]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[23]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/GDP-Ras /kinetics/chain/kinetics[23]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/CaM-GEF /kinetics/chain/kinetics[23]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[23]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM/diff /kinetics/chain/kinetics[23]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca3 /kinetics/chain/kinetics[23]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca4 /kinetics/chain/kinetics[23]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ca /kinetics/chain/kinetics[23]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[23]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[23]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[23]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[23]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[23]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[23]/PKM/trigger_PKM /kinetics/chain/kinetics[23]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[23]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[23]/CaM/CaM /kinetics/chain/kinetics[23]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca /kinetics/chain/kinetics[23]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ca /kinetics/chain/kinetics[23]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[23]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[23]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[23]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca3 /kinetics/chain/kinetics[23]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca2 /kinetics/chain/kinetics[23]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ca /kinetics/chain/kinetics[23]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca2 /kinetics/chain/kinetics[23]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca /kinetics/chain/kinetics[23]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ca /kinetics/chain/kinetics[23]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[23]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[23]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[23]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[23]/Ca REAC A B addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[23]/Ca REAC A B addmsg /kinetics/chain/kinetics[23]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[23]/Ca REAC A B addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[23]/Ca REAC A B addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[23]/Ca REAC A B addmsg /kinetics/chain/kinetics[23]/Ca_diff /kinetics/chain/kinetics[23]/Ca REAC B A addmsg /kinetics/chain/kinetics[22]/Ca/diff /kinetics/chain/kinetics[23]/Ca REAC B A addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1 /kinetics/chain/kinetics[23]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[23]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ras/GTP-Ras /kinetics/chain/kinetics[23]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKM/trigger_PKM /kinetics/chain/kinetics[23]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[22]/PKM/Ca_detector/diff /kinetics/chain/kinetics[23]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[23]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[23]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[23]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[23]/PKM/turn_off_activator /kinetics/chain/kinetics[23]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[22]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[23]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[23]/PKM/PKM_synthesis /kinetics/chain/kinetics[23]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[23]/PKM/AA_pool /kinetics/chain/kinetics[23]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[23]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[23]/PKC/PKM-zeta /kinetics/chain/kinetics[23]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKM/degraded_PKM /kinetics/chain/kinetics[23]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKM/PKM_degradation /kinetics/chain/kinetics[23]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[23]/PKM/trigger_PKM /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[23]/PKM/PKM_activator /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[23]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[23]/PKM/turn_off_activator /kinetics/chain/kinetics[23]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[22]/PKM/PKM_activator/diff /kinetics/chain/kinetics[23]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[23]/PKM/PKM_synthesis /kinetics/chain/kinetics[23]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKM/PKM_activator /kinetics/chain/kinetics[23]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca4 /kinetics/chain/kinetics[23]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKM/Ca_detector /kinetics/chain/kinetics[23]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex /kinetics/chain/kinetics[23]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ca_diff /kinetics/chain/kinetics[23]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[23]/Ca /kinetics/chain/kinetics[23]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ca_input /kinetics/chain/kinetics[23]/Ca_diff SUBSTRATE n enddump // End of dump call /kinetics/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[1]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[1]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[1]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[1]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[1]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[1]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[1]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[1]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[1]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[1]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[1]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[1]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[1]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[1]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[1]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[1]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[1]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[1]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[1]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[1]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[1]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[1]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[1]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[1]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[1]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[1]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[1]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[1]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[1]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[1]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[1]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[1]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[1]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[1]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[1]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[1]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[1]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[1]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[1]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[1]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[1]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[1]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[2]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[2]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[2]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[2]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[2]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[2]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[2]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[2]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[2]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[2]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[2]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[2]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[2]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[2]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[2]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[2]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[2]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[2]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[2]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[2]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[2]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[2]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[2]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[2]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[2]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[2]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[2]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[2]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[2]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[2]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[2]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[2]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[2]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[2]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[2]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[2]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[2]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[2]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[2]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[2]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[2]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[2]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[3]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[3]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[3]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[3]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[3]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[3]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[3]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[3]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[3]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[3]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[3]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[3]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[3]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[3]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[3]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[3]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[3]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[3]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[3]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[3]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[3]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[3]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[3]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[3]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[3]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[3]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[3]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[3]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[3]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[3]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[3]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[3]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[3]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[3]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[3]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[3]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[3]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[3]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[3]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[3]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[3]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[3]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[4]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[4]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[4]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[4]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[4]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[4]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[4]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[4]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[4]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[4]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[4]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[4]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[4]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[4]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[4]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[4]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[4]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[4]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[4]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[4]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[4]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[4]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[4]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[4]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[4]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[4]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[4]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[4]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[4]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[4]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[4]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[4]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[4]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[4]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[4]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[4]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[4]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[4]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[4]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[4]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[4]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[4]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[5]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[5]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[5]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[5]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[5]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[5]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[5]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[5]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[5]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[5]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[5]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[5]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[5]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[5]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[5]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[5]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[5]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[5]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[5]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[5]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[5]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[5]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[5]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[5]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[5]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[5]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[5]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[5]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[5]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[5]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[5]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[5]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[5]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[5]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[5]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[5]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[5]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[5]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[5]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[5]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[5]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[5]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[6]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[6]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[6]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[6]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[6]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[6]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[6]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[6]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[6]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[6]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[6]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[6]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[6]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[6]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[6]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[6]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[6]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[6]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[6]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[6]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[6]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[6]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[6]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[6]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[6]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[6]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[6]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[6]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[6]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[6]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[6]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[6]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[6]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[6]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[6]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[6]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[6]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[6]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[6]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[6]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[6]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[6]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[7]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[7]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[7]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[7]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[7]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[7]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[7]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[7]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[7]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[7]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[7]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[7]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[7]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[7]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[7]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[7]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[7]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[7]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[7]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[7]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[7]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[7]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[7]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[7]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[7]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[7]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[7]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[7]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[7]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[7]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[7]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[7]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[7]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[7]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[7]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[7]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[7]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[7]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[7]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[7]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[7]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[7]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[8]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[8]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[8]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[8]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[8]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[8]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[8]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[8]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[8]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[8]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[8]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[8]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[8]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[8]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[8]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[8]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[8]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[8]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[8]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[8]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[8]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[8]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[8]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[8]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[8]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[8]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[8]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[8]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[8]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[8]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[8]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[8]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[8]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[8]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[8]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[8]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[8]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[8]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[8]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[8]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[8]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[8]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[9]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[9]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[9]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[9]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[9]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[9]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[9]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[9]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[9]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[9]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[9]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[9]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[9]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[9]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[9]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[9]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[9]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[9]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[9]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[9]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[9]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[9]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[9]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[9]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[9]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[9]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[9]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[9]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[9]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[9]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[9]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[9]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[9]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[9]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[9]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[9]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[9]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[9]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[9]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[9]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[9]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[9]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[10]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[10]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[10]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[10]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[10]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[10]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[10]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[10]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[10]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[10]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[10]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[10]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[10]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[10]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[10]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[10]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[10]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[10]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[10]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[10]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[10]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[10]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[10]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[10]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[10]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[10]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[10]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[10]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[10]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[10]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[10]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[10]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[10]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[10]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[10]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[10]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[10]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[10]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[10]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[10]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[10]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[10]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[11]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[11]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[11]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[11]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[11]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[11]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[11]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[11]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[11]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[11]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[11]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[11]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[11]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[11]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[11]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[11]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[11]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[11]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[11]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[11]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[11]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[11]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[11]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[11]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[11]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[11]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[11]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[11]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[11]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[11]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[11]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[11]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[11]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[11]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[11]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[11]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[11]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[11]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[11]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[11]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[11]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[11]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[12]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[12]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[12]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[12]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[12]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[12]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[12]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[12]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[12]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[12]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[12]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[12]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[12]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[12]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[12]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[12]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[12]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[12]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[12]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[12]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[12]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[12]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[12]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[12]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[12]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[12]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[12]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[12]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[12]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[12]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[12]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[12]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[12]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[12]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[12]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[12]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[12]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[12]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[12]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[12]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[12]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[12]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[13]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[13]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[13]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[13]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[13]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[13]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[13]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[13]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[13]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[13]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[13]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[13]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[13]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[13]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[13]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[13]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[13]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[13]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[13]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[13]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[13]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[13]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[13]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[13]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[13]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[13]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[13]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[13]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[13]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[13]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[13]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[13]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[13]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[13]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[13]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[13]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[13]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[13]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[13]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[13]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[13]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[13]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[14]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[14]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[14]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[14]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[14]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[14]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[14]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[14]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[14]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[14]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[14]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[14]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[14]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[14]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[14]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[14]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[14]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[14]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[14]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[14]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[14]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[14]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[14]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[14]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[14]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[14]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[14]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[14]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[14]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[14]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[14]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[14]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[14]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[14]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[14]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[14]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[14]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[14]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[14]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[14]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[14]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[14]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[15]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[15]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[15]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[15]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[15]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[15]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[15]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[15]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[15]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[15]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[15]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[15]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[15]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[15]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[15]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[15]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[15]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[15]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[15]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[15]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[15]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[15]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[15]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[15]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[15]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[15]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[15]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[15]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[15]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[15]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[15]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[15]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[15]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[15]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[15]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[15]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[15]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[15]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[15]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[15]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[15]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[15]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[16]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[16]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[16]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[16]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[16]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[16]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[16]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[16]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[16]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[16]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[16]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[16]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[16]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[16]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[16]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[16]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[16]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[16]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[16]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[16]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[16]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[16]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[16]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[16]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[16]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[16]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[16]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[16]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[16]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[16]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[16]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[16]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[16]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[16]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[16]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[16]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[16]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[16]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[16]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[16]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[16]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[16]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[17]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[17]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[17]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[17]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[17]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[17]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[17]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[17]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[17]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[17]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[17]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[17]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[17]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[17]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[17]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[17]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[17]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[17]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[17]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[17]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[17]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[17]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[17]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[17]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[17]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[17]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[17]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[17]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[17]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[17]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[17]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[17]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[17]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[17]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[17]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[17]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[17]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[17]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[17]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[17]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[17]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[17]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[18]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[18]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[18]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[18]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[18]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[18]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[18]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[18]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[18]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[18]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[18]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[18]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[18]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[18]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[18]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[18]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[18]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[18]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[18]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[18]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[18]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[18]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[18]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[18]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[18]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[18]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[18]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[18]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[18]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[18]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[18]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[18]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[18]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[18]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[18]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[18]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[18]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[18]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[18]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[18]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[18]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[18]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[19]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[19]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[19]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[19]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[19]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[19]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[19]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[19]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[19]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[19]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[19]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[19]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[19]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[19]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[19]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[19]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[19]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[19]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[19]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[19]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[19]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[19]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[19]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[19]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[19]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[19]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[19]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[19]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[19]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[19]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[19]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[19]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[19]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[19]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[19]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[19]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[19]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[19]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[19]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[19]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[19]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[19]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[20]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[20]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[20]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[20]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[20]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[20]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[20]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[20]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[20]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[20]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[20]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[20]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[20]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[20]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[20]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[20]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[20]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[20]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[20]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[20]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[20]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[20]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[20]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[20]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[20]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[20]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[20]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[20]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[20]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[20]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[20]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[20]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[20]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[20]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[20]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[20]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[20]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[20]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[20]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[20]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[20]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[21]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[21]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[21]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[21]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[21]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[21]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[21]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[21]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[21]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[21]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[21]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[21]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[21]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[21]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[21]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[21]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[21]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[21]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[21]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[21]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[21]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[21]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[21]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[21]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[21]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[21]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[21]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[21]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[21]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[21]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[21]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[21]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[21]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[21]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[21]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[21]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[21]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[21]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[21]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[21]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[21]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[21]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[22]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[22]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[22]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[22]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[22]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[22]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[22]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[22]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[22]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[22]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[22]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[22]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[22]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[22]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[22]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[22]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[22]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[22]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[22]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[22]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[22]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[22]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[22]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[22]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[22]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[22]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[22]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[22]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[22]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[22]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[22]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[22]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[22]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[22]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[22]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[22]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[22]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[22]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[22]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[22]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[22]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[22]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[23]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[23]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[23]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[23]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[23]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[23]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[23]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[23]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[23]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[23]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[23]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[23]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[23]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[23]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[23]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[23]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[23]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[23]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[23]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[23]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[23]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[23]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[23]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[23]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[23]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[23]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[23]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[23]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[23]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[23]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[23]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[23]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[23]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[23]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[23]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[23]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[23]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[23]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[23]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[23]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[23]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[23]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/doqcsinfo/notes LOAD \ " This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_PKM model. The original single-compartment model is repeated 25 times. In addition, a subset (27 out of 42) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments.
For D = 1e-12 m^2/sec (i.e., 1 micron^2/sec ) the kf and kb of this reaction for these 10 micron compartments are both 0.01/sec.
For D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) the kf and kb are 0.001/sec.
The stimulus file pkm_mapk22_diff_1e-13_Fig4B which was used for the model to replicate Figure 4B from the paper.
pkm_mapk22_diff_1e-13_Fig4H replicate Figure 4H.
pkm_mapk22_diff_1e-13_Fig4I replicate Figure 4I." complete_loading