//genesis // kkit Version 11 flat dumpfile // Saved on Fri Dec 8 15:17:38 2006 include kkit {argv 1} FASTDT = 1e-05 SIMDT = 0.001 CONTROLDT = 10 PLOTDT = 1 MAXTIME = 5000 TRANSIENT_TIME = 2 VARIABLE_DT_FLAG = 1 DEFAULT_VOL = 1.2566e-16 VERSION = 11.0 setfield /file/modpath value /home2/bhalla/scripts/modules kparms //genesis initdump -version 3 -ignoreorphans 1 simobjdump doqcsinfo filename accessname accesstype transcriber developer \ citation species tissue cellcompartment methodology sources \ model_implementation model_validation x y z simobjdump table input output alloced step_mode stepsize x y z simobjdump xtree path script namemode sizescale simobjdump xcoredraw xmin xmax ymin ymax simobjdump xtext editable simobjdump xgraph xmin xmax ymin ymax overlay simobjdump xplot pixflags script fg ysquish do_slope wy simobjdump group xtree_fg_req xtree_textfg_req plotfield expanded movealone \ link savename file version md5sum mod_save_flag x y z simobjdump geometry size dim shape outside xtree_fg_req xtree_textfg_req x y \ z simobjdump kpool DiffConst CoInit Co n nInit mwt nMin vol slave_enable \ geomname xtree_fg_req xtree_textfg_req x y z simobjdump kreac kf kb notes xtree_fg_req xtree_textfg_req x y z simobjdump kenz CoComplexInit CoComplex nComplexInit nComplex vol k1 k2 k3 \ keepconc usecomplex notes xtree_fg_req xtree_textfg_req link x y z simobjdump stim level1 width1 delay1 level2 width2 delay2 baselevel trig_time \ trig_mode notes xtree_fg_req xtree_textfg_req is_running x y z simobjdump xtab input output alloced step_mode stepsize notes editfunc \ xtree_fg_req xtree_textfg_req baselevel last_x last_y is_running x y z simobjdump kchan perm gmax Vm is_active use_nernst notes xtree_fg_req \ xtree_textfg_req x y z simobjdump transport input output alloced step_mode stepsize dt delay clock \ kf xtree_fg_req xtree_textfg_req x y z simobjdump proto x y z simundump geometry /kinetics/dendgeom 0 1.5e-18 3 cylinder "" white black 8 \ -2 0 simundump group /kinetics/PKC 0 blue black x 0 0 "" defaultfile defaultfile.g \ 0 0 0 -3.0493 8.2163 0 simundump kpool /kinetics/PKC/PKC-Ca 0 -1e-12 0.078942 0.078942 5951.9 5951.9 \ 0 0 75396 4 /kinetics/dendgeom red black -4.0752 1.5108 0 simundump kreac /kinetics/PKC/PKC-Ca/diff 0 0.101 0.001 "" white black \ -3.0752 4.5108 0 simundump kreac /kinetics/PKC/PKC-act-by-Ca 0 7.958e-06 0.5 "" white blue \ -4.0752 -0.12295 0 simundump kreac /kinetics/PKC/PKC-act-by-DAG 0 1.061e-07 8.6348 "" white blue \ -2.0612 0.69395 0 simundump kreac /kinetics/PKC/PKC-Ca-to-memb 0 1.2705 3.5026 "" white blue \ -3.7974 4.2533 0 simundump kreac /kinetics/PKC/PKC-DAG-to-memb 0 1 0.1 "" white blue -2.6168 \ 2.7362 0 simundump kpool /kinetics/PKC/PKC-Ca-memb* 0 -1e-12 0.028634 0.028634 2158.9 \ 2158.9 0 0 75396 4 /kinetics/dendgeom pink blue -2.7788 6.529 0 simundump kreac /kinetics/PKC/PKC-Ca-memb*/diff 0 0.101 0.001 "" white black \ -1.7788 9.529 0 simundump kpool /kinetics/PKC/PKC-DAG-memb* 0 -1e-12 0.0089225 0.0089225 \ 672.72 672.72 0 0 75396 4 /kinetics/dendgeom yellow blue -1.8297 5.5078 0 simundump kreac /kinetics/PKC/PKC-DAG-memb*/diff 0 0.101 0.001 "" white black \ -0.8297 8.5078 0 simundump kpool /kinetics/PKC/PKC-Ca-DAG 0 -1e-12 0.00089226 0.00089226 \ 67.273 67.273 0 0 75396 4 /kinetics/dendgeom white blue 0.2306 1.8026 0 simundump kreac /kinetics/PKC/PKC-Ca-DAG/diff 0 0.101 0.001 "" white black \ 1.2306 4.8026 0 simundump kreac /kinetics/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" white blue -3.0103 \ -1.9902 0 simundump kpool /kinetics/PKC/PKC-DAG 0 -1e-12 0.060193 0.060193 4538.3 \ 4538.3 0 0 75396 4 /kinetics/dendgeom white blue -0.99631 -1.0857 0 simundump kreac /kinetics/PKC/PKC-DAG/diff 0 0.101 0.001 "" white black \ 0.00369 1.9143 0 simundump kpool /kinetics/PKC/PKC-cytosolic 0 -1e-12 0.8223 0.8223 61998 \ 61998 0 0 75396 4 /kinetics/dendgeom white blue -6.1315 0.59711 0 simundump kreac /kinetics/PKC/PKC-cytosolic/diff 0 0.101 0.001 "" white black \ -5.1315 3.5971 0 simundump kpool /kinetics/PKC/PKM-zeta 0 -1e-12 0.01007 0.01007 759.21 759.21 \ 0 0 75396 4 /kinetics/dendgeom cyan blue -3 11 0 simundump kreac /kinetics/PKC/PKM-zeta/diff 0 0.101 0.001 "" white black -2 \ 14 0 simundump kpool /kinetics/DAG 1 -1e-12 12.2 12.2 9.1983e+05 9.1983e+05 0 0 \ 75396 4 /kinetics/dendgeom green black 4 -3 0 simundump kpool /kinetics/PKC-active 1 -1e-12 0.047627 0.047626 3590.8 3590.9 \ 0 0 75396 4 /kinetics/dendgeom red black 0 9 0 simundump kenz /kinetics/PKC-active/PKC-act-raf 1 0.0011493 0.0011493 86.652 \ 86.652 75396 1.3263e-05 16 4 0 0 "" red yellow "" 6 10 0 simundump kenz /kinetics/PKC-active/PKC-inact-GAP 1 53.939 53.939 6.778 6.778 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 4 13 0 simundump kenz /kinetics/PKC-active/PKC-act-GEF 1 726.99 726.99 91.354 91.354 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 9 20 0 simundump kpool /kinetics/MAPK* 1 -1e-12 7.8539e-05 7.8539e-05 5.9215 5.9215 \ 0 0 75396 4 /kinetics/dendgeom orange yellow 13 1 0 simundump kenz /kinetics/MAPK*/MAPK*-feedback 1 3.6779e-08 3.6779e-08 \ 0.002773 0.002773 75396 2.5864e-05 40 10 0 0 "" red orange "" 10 10 0 simundump kreac /kinetics/MAPK*/diff 0 0.101 0.001 "" white black 14 4 0 simundump group /kinetics/MAPK 0 brown black x 0 0 "" defaultfile \ defaultfile.g 0 0 0 15 11 0 simundump kpool /kinetics/MAPK/craf-1 0 0 0.48263 0.48263 36388 36388 0 0 \ 75396 4 /kinetics/dendgeom pink brown 6 8 0 simundump kreac /kinetics/MAPK/craf-1/diff 0 0.101 0.001 "" white black 7 11 \ 0 simundump kpool /kinetics/MAPK/craf-1* 0 0 0.012007 0.012007 905.28 905.28 0 \ 0 75396 4 /kinetics/dendgeom pink brown 9 8 0 simundump kreac /kinetics/MAPK/craf-1*/diff 0 0.101 0.001 "" white black 10 \ 11 0 simundump kpool /kinetics/MAPK/MAPKK 0 0 0.4946 0.4946 37291 37291 0 0 75396 \ 4 /kinetics/dendgeom pink brown 6 4 0 simundump kreac /kinetics/MAPK/MAPKK/diff 0 0.101 0.001 "" white black 7 7 0 simundump kpool /kinetics/MAPK/MAPK 0 -1e-12 3.5824 3.5824 2.701e+05 \ 2.701e+05 0 0 75396 4 /kinetics/dendgeom pink brown 6 1 0 simundump kreac /kinetics/MAPK/MAPK/diff 0 0.101 0.001 "" white black 7 4 0 simundump kpool /kinetics/MAPK/craf-1** 1 0 9.6059e-07 9.6059e-07 0.072425 \ 0.072425 0 0 75396 4 /kinetics/dendgeom hotpink brown 12 8 0 simundump kreac /kinetics/MAPK/craf-1**/diff 0 0.101 0.001 "" white black 13 \ 11 0 simundump kpool /kinetics/MAPK/MAPK-tyr 1 -1e-12 0.016774 0.016774 1264.7 \ 1264.7 0 0 75396 4 /kinetics/dendgeom orange brown 9 1 0 simundump kreac /kinetics/MAPK/MAPK-tyr/diff 0 0.101 0.001 "" white black 10 \ 4 0 simundump kpool /kinetics/MAPK/MAPKK* 0 0 8.2386e-06 8.2386e-06 0.62116 \ 0.62116 0 0 75396 4 /kinetics/dendgeom pink brown 13 4 0 simundump kenz /kinetics/MAPK/MAPKK*/MAPKKtyr 0 0.00063751 0.00063751 48.066 \ 48.066 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 8 3 0 simundump kenz /kinetics/MAPK/MAPKK*/MAPKKthr 1 2.985e-06 2.985e-06 0.22506 \ 0.22506 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 13 3 0 simundump kreac /kinetics/MAPK/MAPKK*/diff 0 0.101 0.001 "" white black 14 7 \ 0 simundump kpool /kinetics/MAPK/MAPKK-ser 1 0 0.0020188 0.0020188 152.21 \ 152.21 0 0 75396 4 /kinetics/dendgeom pink brown 9 4 0 simundump kreac /kinetics/MAPK/MAPKK-ser/diff 0 0.101 0.001 "" white black 10 \ 7 0 simundump kpool /kinetics/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 75396 4 \ /kinetics/dendgeom 55 brown 5 6 0 simundump kenz /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 0 0 0 0 75396 \ 0.00012505 1.2 0.3 0 0 "" red 55 "" 8 6 0 simundump kenz /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 0 0 0 0 75396 \ 0.00012505 1.2 0.3 0 0 "" red 55 "" 11 6 0 simundump kreac /kinetics/MAPK/Raf-GTP-Ras/diff 0 0.101 0.001 "" white black \ 6 9 0 simundump kpool /kinetics/MAPK/Raf*-GTP-Ras 1 0 0.00082874 0.00082874 62.484 \ 62.484 0 0 75396 4 /kinetics/dendgeom red brown 5 5 0 simundump kenz /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 1545.9 1545.9 \ 194.26 194.26 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 8 5 0 simundump kenz /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 6.3096 6.3096 \ 0.79287 0.79287 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 11 5 0 simundump kreac /kinetics/MAPK/Raf*-GTP-Ras/diff 0 0.101 0.001 "" white black \ 6 8 0 simundump kpool /kinetics/MKP-1 1 -1e-12 0.019951 0.019951 1504.2 1504.2 0 0 \ 75396 4 /kinetics/dendgeom hotpink black 5 2 0 simundump kenz /kinetics/MKP-1/MKP1-tyr-deph 1 4.781e-05 4.781e-05 3.6047 \ 3.6047 75396 3.7895e-05 16 4 0 0 "" red hotpink "" 6 3 0 simundump kenz /kinetics/MKP-1/MKP1-thr-deph 1 2.2386e-07 2.2386e-07 0.016878 \ 0.016878 75396 3.7895e-05 16 4 0 0 "" red hotpink "" 11 3 0 simundump kreac /kinetics/MKP-1/diff 0 0.101 0.001 "" white black 6 5 0 simundump kreac /kinetics/Ras-act-craf 1 0.00013263 0.5 "" white black 3 9 0 simundump kpool /kinetics/PPhosphatase2A 1 -1e-12 0.9991 0.9991 75328 75328 0 \ 0 75396 4 /kinetics/dendgeom hotpink yellow 9 9 0 simundump kenz /kinetics/PPhosphatase2A/craf-deph 1 0.00076621 0.00076621 \ 57.769 57.769 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 8 10 0 simundump kenz /kinetics/PPhosphatase2A/MAPKK-deph 1 5.2573e-07 5.2573e-07 \ 0.039638 0.039638 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 11 7 0 simundump kenz /kinetics/PPhosphatase2A/MAPKK-deph-ser 1 0.00012882 \ 0.00012882 9.7128 9.7128 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 8 7 0 simundump kenz /kinetics/PPhosphatase2A/craf**-deph 1 0.036779 0.036779 \ 0.0046216 0.0046216 0.12566 2.5414e-05 24 6 0 0 "" red hotpink "" 12 10 0 simundump kreac /kinetics/PPhosphatase2A/diff 0 0.101 0.001 "" white black 10 \ 12 0 simundump group /kinetics/Ras 1 blue black x 0 0 "" defaultfile defaultfile.g \ 0 0 0 14.513 16.351 0 simundump kreac /kinetics/Ras/dephosph-GEF 1 1 0 "" white blue 9.0702 17.881 \ 0 simundump kpool /kinetics/Ras/inact-GEF 1 -1e-12 0.084803 0.084803 6393.8 \ 6393.8 0 0 75396 4 /kinetics/dendgeom hotpink blue 12.453 18.352 0 simundump kenz /kinetics/Ras/inact-GEF/basal_GEF_activity 0 0.0040648 \ 0.0040648 306.47 306.47 75396 1.313e-07 0.08 0.02 0 0 "" red hotpink "" 12 \ 17 0 simundump kreac /kinetics/Ras/inact-GEF/diff 0 0.101 0.001 "" white black \ 13.453 21.352 0 simundump kpool /kinetics/Ras/GEF* 1 -1e-12 0.0048465 0.0048465 365.41 365.41 \ 0 0 75396 4 /kinetics/dendgeom hotpink blue 6.4483 17.246 0 simundump kenz /kinetics/Ras/GEF*/GEF*-act-ras 1 0.0046465 0.0046465 350.33 \ 350.33 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 7.0855 16.086 0 simundump kreac /kinetics/Ras/GEF*/diff 0 0.101 0.001 "" white black 7.4483 \ 20.246 0 simundump kpool /kinetics/Ras/GTP-Ras 1 0 0.0034512 0.0034512 260.21 260.21 0 \ 0 75396 4 /kinetics/dendgeom orange blue 12.564 13.084 0 simundump kreac /kinetics/Ras/GTP-Ras/diff 0 0.101 0.001 "" white black \ 13.564 16.084 0 simundump kpool /kinetics/Ras/GDP-Ras 1 0 0.48419 0.48419 36506 36506 0 0 \ 75396 4 /kinetics/dendgeom pink blue 6.1309 14.165 0 simundump kreac /kinetics/Ras/GDP-Ras/diff 0 0.101 0.001 "" white black \ 7.1309 17.165 0 simundump kreac /kinetics/Ras/Ras-intrinsic-GTPase 1 1e-04 0 "" white blue \ 9.0979 13.5 0 simundump kreac /kinetics/Ras/dephosph-GAP 1 0.1 0 "" white blue 4.0234 \ 15.524 0 simundump kpool /kinetics/Ras/GAP* 1 -1e-12 0.0035959 0.0035959 271.12 271.12 \ 0 0 75396 4 /kinetics/dendgeom red blue 1.3498 14.349 0 simundump kreac /kinetics/Ras/GAP*/diff 0 0.101 0.001 "" white black 2.3498 \ 17.349 0 simundump kpool /kinetics/Ras/GAP 1 -1e-12 0.0062918 0.0062918 474.38 474.38 \ 0 0 75396 4 /kinetics/dendgeom red blue 6.6549 12.338 0 simundump kenz /kinetics/Ras/GAP/GAP-inact-ras 1 2.1491e-05 2.1491e-05 1.6203 \ 1.6203 75396 0.00065634 40 10 0 0 "" red red "" 9.0121 12.403 0 simundump kreac /kinetics/Ras/GAP/diff 0 0.101 0.001 "" white black 7.6549 \ 15.338 0 simundump kreac /kinetics/Ras/CaM-bind-GEF 1 0.0026526 1 "" white blue 2.4861 \ 21.679 0 simundump kpool /kinetics/Ras/CaM-GEF 1 -1e-12 0.00021398 0.00021398 16.133 \ 16.133 0 0 75396 4 /kinetics/dendgeom pink blue 5.3451 19.58 0 simundump kenz /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras 1 0.00020513 0.00020513 \ 15.466 15.466 75396 2.6261e-05 0.8 0.2 0 0 "" red pink "" 5.0223 18.657 0 simundump kreac /kinetics/Ras/CaM-GEF/diff 0 0.101 0.001 "" white black \ 6.3451 22.58 0 simundump group /kinetics/CaM 1 blue black x 0 0 "" defaultfile defaultfile.g \ 0 0 0 -10 21 0 simundump kpool /kinetics/CaM/CaM 1 -1e-12 18.403 18.403 1.3875e+06 \ 1.3875e+06 0 0 75396 4 /kinetics/dendgeom pink blue -13 30 0 simundump kreac /kinetics/CaM/CaM/diff 0 0.101 0.001 "" white black -12 33 0 simundump kreac /kinetics/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 10 "" white blue \ -10.4 23.26 0 simundump kpool /kinetics/CaM/CaM-Ca3 1 -1e-12 0.0033914 0.0033914 255.7 \ 255.7 0 0 75396 4 /kinetics/dendgeom hotpink blue -6.511 24.397 0 simundump kreac /kinetics/CaM/CaM-Ca3/diff 0 0.101 0.001 "" white black \ -5.511 27.397 0 simundump kpool /kinetics/CaM/CaM-Ca4 1 -1e-12 1.2616e-05 1.2616e-05 0.95122 \ 0.95122 0 0 75396 4 /kinetics/dendgeom blue blue -2 24 0 simundump kreac /kinetics/CaM/CaM-Ca4/diff 0 0.101 0.001 "" white black -1 27 \ 0 simundump kreac /kinetics/CaM/CaM-bind-Ca 1 0.00011254 8.4853 "" white blue \ -10 30 0 simundump kpool /kinetics/CaM/CaM-Ca2 1 -1e-12 0.11776 0.11776 8878.5 8878.5 \ 0 0 75396 4 /kinetics/dendgeom pink blue -5.001 27.258 0 simundump kreac /kinetics/CaM/CaM-Ca2/diff 0 0.101 0.001 "" white black \ -4.001 30.258 0 simundump kreac /kinetics/CaM/CaM-Ca2-bind-Ca 1 4.7748e-05 10 "" white blue \ -8.842 26.225 0 simundump kreac /kinetics/CaM/CaM-Ca-bind-Ca 1 0.00011254 8.4853 "" white \ blue -4 30 0 simundump kpool /kinetics/CaM/CaM-Ca 1 -1e-12 1.472 1.472 1.1098e+05 \ 1.1098e+05 0 0 75396 4 /kinetics/dendgeom pink blue -7 31 0 simundump kreac /kinetics/CaM/CaM-Ca/diff 0 0.101 0.001 "" white black -6 34 \ 0 simundump kpool /kinetics/Ca 1 -1e-12 0.08 0.08 6031.7 6031.7 0 0 75396 4 \ /kinetics/dendgeom red black -18 23 0 simundump kreac /kinetics/Ca/diff 0 0.101 0.001 "" white black -17 26 0 simundump kreac /kinetics/Ras-act-unphosph-raf 0 0 0 "" white black 4 8 0 simundump group /kinetics/PKM 0 25 black x 0 0 "" PKM defaultfile.g 0 \ 5dc016e940e88c1cc7928f4e096ff523 0 -7 19 0 simundump kpool /kinetics/PKM/Ca_detector 0 -1e-12 0.99987 0.99987 75386 \ 75386 0 0 75396 4 /kinetics/dendgeom 7 25 -11 17 0 simundump kreac /kinetics/PKM/Ca_detector/diff 0 0.101 0.001 "" white black \ -10 20 0 simundump kpool /kinetics/PKM/PKM_synthesis 0 -1e-12 0.0010085 0.0010085 \ 76.04 76.04 0 0 75396 4 /kinetics/dendgeom 8 25 -11 9 0 simundump kenz /kinetics/PKM/PKM_synthesis/kenz 0 0.00010086 0.00010086 \ 7.6041 7.6041 75396 3.3159e-07 0.2 0.05 0 0 "" red 8 "" -10 10 0 simundump kreac /kinetics/PKM/PKM_synthesis/diff 0 0.101 0.001 "" white black \ -10 12 0 simundump kpool /kinetics/PKM/AA_pool 0 -1e-12 1 1 75396 75396 0 0 75396 4 \ /kinetics/dendgeom 9 25 -7 12 0 simundump kreac /kinetics/PKM/PKM_degradation 0 0.0005 0 "" white 25 -8 7 0 simundump kpool /kinetics/PKM/degraded_PKM 0 -1e-12 0 0 0 0 0 0 75396 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/kinetics/chain 0 yellow black x 0 0 "" defaultfile \ defaultfile.g 0 0 0 4 0 0 simundump group /kinetics/chain/kinetics 0 yellow black x 0 0 "" defaultfile \ defaultfile.g 0 0 0 4 0 0 simundump group /kinetics/chain/kinetics/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 0.9507 8.2163 0 simundump kpool /kinetics/chain/kinetics/PKC/PKC-Ca 0 -1e-12 0.078942 \ 0.078942 5951.9 5951.9 0 0 75396 0 /kinetics/dendgeom red black -0.0752 \ 1.5108 0 simundump kreac /kinetics/chain/kinetics/PKC/PKC-Ca/diff 0 0.101 0.001 "" \ white black 0.9248 4.5108 0 simundump kreac /kinetics/chain/kinetics/PKC/PKC-act-by-Ca 0 7.958e-06 0.5 "" \ white blue -0.0752 -0.12295 0 simundump kreac /kinetics/chain/kinetics/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 1.9388 0.69395 0 simundump kreac /kinetics/chain/kinetics/PKC/PKC-Ca-to-memb 0 1.2705 3.5026 \ "" white blue 0.2026 4.2533 0 simundump kreac /kinetics/chain/kinetics/PKC/PKC-DAG-to-memb 0 1 0.1 "" white \ blue 1.3832 2.7362 0 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4538.3 4538.3 0 0 75396 0 /kinetics/dendgeom white blue 3.0037 \ -1.0857 0 simundump kreac /kinetics/chain/kinetics/PKC/PKC-DAG/diff 0 0.101 0.001 "" \ white black 4.0037 1.9143 0 simundump kpool /kinetics/chain/kinetics/PKC/PKC-cytosolic 0 -1e-12 0.8223 \ 0.8223 61998 61998 0 0 75396 0 /kinetics/dendgeom white blue -2.1315 \ 0.59711 0 simundump kreac /kinetics/chain/kinetics/PKC/PKC-cytosolic/diff 0 0.101 0.001 \ "" white black -1.1315 3.5971 0 simundump kpool /kinetics/chain/kinetics/PKC/PKM-zeta 0 -1e-12 0.01007 \ 0.01007 759.21 759.21 0 0 75396 0 /kinetics/dendgeom cyan blue 1 11 0 simundump kreac /kinetics/chain/kinetics/PKC/PKM-zeta/diff 0 0.101 0.001 "" \ white black 2 14 0 simundump kpool /kinetics/chain/kinetics/DAG 1 -1e-12 12.2 12.2 9.1983e+05 \ 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 8 -3 0 simundump kpool /kinetics/chain/kinetics/PKC-active 1 -1e-12 0.047627 \ 0.047626 3590.8 3590.9 0 0 75396 2 /kinetics/dendgeom red black 4 9 0 simundump kenz 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75396 0 /kinetics/dendgeom red black -10 23 0 simundump kreac /kinetics/chain/kinetics[1]/Ca/diff 0 0.101 0.001 "" white \ black -9 26 0 simundump kreac /kinetics/chain/kinetics[1]/Ras-act-unphosph-raf 0 0 0 "" \ white black 12 8 0 simundump group /kinetics/chain/kinetics[1]/PKM 0 25 black x 0 0 "" PKM \ defaultfile.g 0 5dc016e940e88c1cc7928f4e096ff523 0 1 19 0 simundump kpool /kinetics/chain/kinetics[1]/PKM/Ca_detector 0 -1e-12 0.99987 \ 0.99987 75386 75386 0 0 75396 0 /kinetics/dendgeom 7 25 -3 17 0 simundump kreac /kinetics/chain/kinetics[1]/PKM/Ca_detector/diff 0 0.101 \ 0.001 "" white black -2 20 0 simundump kpool /kinetics/chain/kinetics[1]/PKM/PKM_synthesis 0 -1e-12 \ 0.0010085 0.0010085 76.04 76.04 0 0 75396 0 /kinetics/dendgeom 8 25 -3 9 0 simundump kenz /kinetics/chain/kinetics[1]/PKM/PKM_synthesis/kenz 0 \ 0.00010086 0.00010086 7.6041 7.6041 75396 3.3159e-07 0.2 0.05 0 0 "" red 8 \ "" -2 10 0 simundump kreac /kinetics/chain/kinetics[1]/PKM/PKM_synthesis/diff 0 0.101 \ 0.001 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16 4 0 0 "" red yellow "" 28 13 0 simundump kenz /kinetics/chain/kinetics[5]/PKC-active/PKC-act-GEF 1 726.99 \ 726.99 91.354 91.354 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 33 20 0 simundump kpool /kinetics/chain/kinetics[5]/MAPK* 1 -1e-12 7.8539e-05 \ 7.8539e-05 5.9215 5.9215 0 0 75396 0 /kinetics/dendgeom orange yellow 37 1 \ 0 simundump kenz /kinetics/chain/kinetics[5]/MAPK*/MAPK*-feedback 1 3.6779e-08 \ 3.6779e-08 0.002773 0.002773 75396 2.5864e-05 40 10 0 0 "" red orange "" 34 \ 10 0 simundump kreac /kinetics/chain/kinetics[5]/MAPK*/diff 0 0.101 0.001 "" white \ black 38 4 0 simundump group /kinetics/chain/kinetics[5]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 39 11 0 simundump kpool /kinetics/chain/kinetics[5]/MAPK/craf-1 0 0 0.48263 0.48263 \ 36388 36388 0 0 75396 0 /kinetics/dendgeom pink brown 30 8 0 simundump kreac /kinetics/chain/kinetics[5]/MAPK/craf-1/diff 0 0.101 0.001 "" \ white black 31 11 0 simundump kpool /kinetics/chain/kinetics[5]/MAPK/craf-1* 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group /kinetics/chain/kinetics[6]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 43 11 0 simundump kpool /kinetics/chain/kinetics[6]/MAPK/craf-1 0 0 0.48263 0.48263 \ 36388 36388 0 0 75396 0 /kinetics/dendgeom pink brown 34 8 0 simundump kreac /kinetics/chain/kinetics[6]/MAPK/craf-1/diff 0 0.101 0.001 "" \ white black 35 11 0 simundump kpool /kinetics/chain/kinetics[6]/MAPK/craf-1* 0 0 0.012007 \ 0.012007 905.28 905.28 0 0 75396 0 /kinetics/dendgeom pink brown 37 8 0 simundump kreac /kinetics/chain/kinetics[6]/MAPK/craf-1*/diff 0 0.101 0.001 \ "" white black 38 11 0 simundump kpool /kinetics/chain/kinetics[6]/MAPK/MAPKK 0 0 0.4946 0.4946 \ 37291 37291 0 0 75396 0 /kinetics/dendgeom pink brown 34 4 0 simundump kreac /kinetics/chain/kinetics[6]/MAPK/MAPKK/diff 0 0.101 0.001 "" \ white black 35 7 0 simundump kpool /kinetics/chain/kinetics[6]/MAPK/MAPK 0 -1e-12 3.5824 3.5824 \ 2.701e+05 2.701e+05 0 0 75396 0 /kinetics/dendgeom pink brown 34 1 0 simundump kreac 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2.6261e-05 0.8 0.2 0 0 "" red \ pink "" 33.022 18.657 0 simundump kreac /kinetics/chain/kinetics[6]/Ras/CaM-GEF/diff 0 0.101 0.001 "" \ white black 34.345 22.58 0 simundump group /kinetics/chain/kinetics[6]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 18 21 0 simundump kpool /kinetics/chain/kinetics[6]/CaM/CaM 1 -1e-12 18.403 18.403 \ 1.3875e+06 1.3875e+06 0 0 75396 0 /kinetics/dendgeom pink blue 15 30 0 simundump kreac /kinetics/chain/kinetics[6]/CaM/CaM/diff 0 0.101 0.001 "" \ white black 16 33 0 simundump kreac /kinetics/chain/kinetics[6]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 17.6 23.26 0 simundump kpool /kinetics/chain/kinetics[6]/CaM/CaM-Ca3 1 -1e-12 0.0033914 \ 0.0033914 255.7 255.7 0 0 75396 0 /kinetics/dendgeom hotpink blue 21.489 \ 24.397 0 simundump kreac /kinetics/chain/kinetics[6]/CaM/CaM-Ca3/diff 0 0.101 0.001 "" \ white black 22.489 27.397 0 simundump kpool /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 1 -1e-12 1.2616e-05 \ 1.2616e-05 0.95122 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75396 0 /kinetics/dendgeom 6 25 13 12 0 simundump kreac /kinetics/chain/kinetics[6]/PKM/PKM_activator/diff 0 0.101 \ 0.001 "" white black 14 15 0 simundump kreac /kinetics/chain/kinetics[6]/PKM/turn_off_activator 0 0.001 0 \ "" white 25 11 9 0 simundump kreac /kinetics/chain/kinetics[6]/PKM/trigger_PKM 0 0.00013263 1 "" \ white 25 11 16 0 simundump kpool /kinetics/chain/kinetics[6]/Ca_input 0 0 0.08 0.08 6031.7 \ 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 10 30 0 simundump kreac /kinetics/chain/kinetics[6]/Ca_diff 0 5 5 "" white black 10 \ 26 0 simundump group /kinetics/chain/kinetics[7] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 32 0 0 simundump group /kinetics/chain/kinetics[7]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 28.951 8.2163 0 simundump kpool /kinetics/chain/kinetics[7]/PKC/PKC-Ca 0 -1e-12 0.078942 \ 0.078942 5951.9 5951.9 0 0 75396 0 /kinetics/dendgeom red black 27.925 \ 1.5108 0 simundump kreac /kinetics/chain/kinetics[7]/PKC/PKC-Ca/diff 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/kinetics/chain/kinetics[7]/MAPK* 1 -1e-12 7.8539e-05 \ 7.8539e-05 5.9215 5.9215 0 0 75396 0 /kinetics/dendgeom orange yellow 45 1 \ 0 simundump kenz /kinetics/chain/kinetics[7]/MAPK*/MAPK*-feedback 1 3.6779e-08 \ 3.6779e-08 0.002773 0.002773 75396 2.5864e-05 40 10 0 0 "" red orange "" 42 \ 10 0 simundump kreac /kinetics/chain/kinetics[7]/MAPK*/diff 0 0.101 0.001 "" white \ black 46 4 0 simundump group /kinetics/chain/kinetics[7]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 47 11 0 simundump kpool /kinetics/chain/kinetics[7]/MAPK/craf-1 0 0 0.48263 0.48263 \ 36388 36388 0 0 75396 0 /kinetics/dendgeom pink brown 38 8 0 simundump kreac /kinetics/chain/kinetics[7]/MAPK/craf-1/diff 0 0.101 0.001 "" \ white black 39 11 0 simundump kpool /kinetics/chain/kinetics[7]/MAPK/craf-1* 0 0 0.012007 \ 0.012007 905.28 905.28 0 0 75396 0 /kinetics/dendgeom pink brown 41 8 0 simundump kreac /kinetics/chain/kinetics[7]/MAPK/craf-1*/diff 0 0.101 0.001 \ "" white black 42 11 0 simundump 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86.652 75396 1.3263e-05 16 4 0 0 "" red yellow "" 42 10 0 simundump kenz /kinetics/chain/kinetics[8]/PKC-active/PKC-inact-GAP 1 53.939 \ 53.939 6.778 6.778 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 40 13 0 simundump kenz /kinetics/chain/kinetics[8]/PKC-active/PKC-act-GEF 1 726.99 \ 726.99 91.354 91.354 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 45 20 0 simundump kpool /kinetics/chain/kinetics[8]/MAPK* 1 -1e-12 7.8539e-05 \ 7.8539e-05 5.9215 5.9215 0 0 75396 0 /kinetics/dendgeom orange yellow 49 1 \ 0 simundump kenz /kinetics/chain/kinetics[8]/MAPK*/MAPK*-feedback 1 3.6779e-08 \ 3.6779e-08 0.002773 0.002773 75396 2.5864e-05 40 10 0 0 "" red orange "" 46 \ 10 0 simundump kreac /kinetics/chain/kinetics[8]/MAPK*/diff 0 0.101 0.001 "" white \ black 50 4 0 simundump group /kinetics/chain/kinetics[8]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 51 11 0 simundump kpool /kinetics/chain/kinetics[8]/MAPK/craf-1 0 0 0.48263 0.48263 \ 36388 36388 0 0 75396 0 /kinetics/dendgeom pink brown 42 8 0 simundump kreac /kinetics/chain/kinetics[8]/MAPK/craf-1/diff 0 0.101 0.001 "" \ white black 43 11 0 simundump kpool /kinetics/chain/kinetics[8]/MAPK/craf-1* 0 0 0.012007 \ 0.012007 905.28 905.28 0 0 75396 0 /kinetics/dendgeom pink brown 45 8 0 simundump kreac /kinetics/chain/kinetics[8]/MAPK/craf-1*/diff 0 0.101 0.001 \ "" white black 46 11 0 simundump kpool /kinetics/chain/kinetics[8]/MAPK/MAPKK 0 0 0.4946 0.4946 \ 37291 37291 0 0 75396 0 /kinetics/dendgeom pink brown 42 4 0 simundump kreac /kinetics/chain/kinetics[8]/MAPK/MAPKK/diff 0 0.101 0.001 "" \ white black 43 7 0 simundump kpool /kinetics/chain/kinetics[8]/MAPK/MAPK 0 -1e-12 3.5824 3.5824 \ 2.701e+05 2.701e+05 0 0 75396 0 /kinetics/dendgeom pink brown 42 1 0 simundump kreac /kinetics/chain/kinetics[8]/MAPK/MAPK/diff 0 0.101 0.001 "" \ white black 43 4 0 simundump kpool /kinetics/chain/kinetics[8]/MAPK/craf-1** 1 0 9.6059e-07 \ 9.6059e-07 0.072425 0.072425 0 0 75396 0 /kinetics/dendgeom hotpink brown \ 48 8 0 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0.12566 7.958e-05 16 4 0 0 "" red yellow "" 48 13 0 simundump kenz /kinetics/chain/kinetics[10]/PKC-active/PKC-act-GEF 1 726.99 \ 726.99 91.354 91.354 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 53 20 0 simundump kpool /kinetics/chain/kinetics[10]/MAPK* 1 -1e-12 7.8539e-05 \ 7.8539e-05 5.9215 5.9215 0 0 75396 0 /kinetics/dendgeom orange yellow 57 1 \ 0 simundump kenz /kinetics/chain/kinetics[10]/MAPK*/MAPK*-feedback 1 3.6779e-08 \ 3.6779e-08 0.002773 0.002773 75396 2.5864e-05 40 10 0 0 "" red orange "" 54 \ 10 0 simundump kreac /kinetics/chain/kinetics[10]/MAPK*/diff 0 0.101 0.001 "" \ white black 58 4 0 simundump group /kinetics/chain/kinetics[10]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 59 11 0 simundump kpool /kinetics/chain/kinetics[10]/MAPK/craf-1 0 0 0.48263 0.48263 \ 36388 36388 0 0 75396 0 /kinetics/dendgeom pink brown 50 8 0 simundump kreac /kinetics/chain/kinetics[10]/MAPK/craf-1/diff 0 0.101 0.001 \ "" white black 51 11 0 simundump kpool 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2.701e+05 2.701e+05 0 0 75396 0 /kinetics/dendgeom pink brown 66 1 0 simundump kreac /kinetics/chain/kinetics[14]/MAPK/MAPK/diff 0 0.101 0.001 "" \ white black 67 4 0 simundump kpool /kinetics/chain/kinetics[14]/MAPK/craf-1** 1 0 9.6059e-07 \ 9.6059e-07 0.072425 0.072425 0 0 75396 0 /kinetics/dendgeom hotpink brown \ 72 8 0 simundump kreac /kinetics/chain/kinetics[14]/MAPK/craf-1**/diff 0 0.101 0.001 \ "" white black 73 11 0 simundump kpool /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr 1 -1e-12 0.016774 \ 0.016774 1264.7 1264.7 0 0 75396 0 /kinetics/dendgeom orange brown 69 1 0 simundump kreac /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr/diff 0 0.101 0.001 \ "" white black 70 4 0 simundump kpool /kinetics/chain/kinetics[14]/MAPK/MAPKK* 0 0 8.2386e-06 \ 8.2386e-06 0.62116 0.62116 0 0 75396 0 /kinetics/dendgeom pink brown 73 4 0 simundump kenz /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKtyr 0 0.00063751 \ 0.00063751 48.066 48.066 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 68 3 0 simundump 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3.7895e-05 16 4 0 0 "" red hotpink "" 71 \ 3 0 simundump kreac /kinetics/chain/kinetics[14]/MKP-1/diff 0 0.101 0.001 "" \ white black 66 5 0 simundump kreac /kinetics/chain/kinetics[14]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 63 9 0 simundump kpool /kinetics/chain/kinetics[14]/PPhosphatase2A 1 -1e-12 0.9991 \ 0.9991 75328 75328 0 0 75396 0 /kinetics/dendgeom hotpink yellow 69 9 0 simundump kenz /kinetics/chain/kinetics[14]/PPhosphatase2A/craf-deph 1 \ 0.00076621 0.00076621 57.769 57.769 75396 2.5414e-05 24 6 0 0 "" red \ hotpink "" 68 10 0 simundump kenz /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph 1 \ 5.2573e-07 5.2573e-07 0.039638 0.039638 75396 2.5414e-05 24 6 0 0 "" red \ hotpink "" 71 7 0 simundump kenz /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph-ser 1 \ 0.00012882 0.00012882 9.7128 9.7128 75396 2.5414e-05 24 6 0 0 "" red \ hotpink "" 68 7 0 simundump kenz /kinetics/chain/kinetics[14]/PPhosphatase2A/craf**-deph 1 \ 0.036779 0.036779 0.0046216 0.0046216 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0 simundump kpool /kinetics/chain/kinetics[14]/Ras/GAP* 1 -1e-12 0.0035959 \ 0.0035959 271.12 271.12 0 0 75396 0 /kinetics/dendgeom red blue 61.35 \ 14.349 0 simundump kreac /kinetics/chain/kinetics[14]/Ras/GAP*/diff 0 0.101 0.001 "" \ white black 62.35 17.349 0 simundump kpool /kinetics/chain/kinetics[14]/Ras/GAP 1 -1e-12 0.0062918 \ 0.0062918 474.38 474.38 0 0 75396 0 /kinetics/dendgeom red blue 66.655 \ 12.338 0 simundump kenz /kinetics/chain/kinetics[14]/Ras/GAP/GAP-inact-ras 1 \ 2.1491e-05 2.1491e-05 1.6203 1.6203 75396 0.00065634 40 10 0 0 "" red red \ "" 69.012 12.403 0 simundump kreac /kinetics/chain/kinetics[14]/Ras/GAP/diff 0 0.101 0.001 "" \ white black 67.655 15.338 0 simundump kreac /kinetics/chain/kinetics[14]/Ras/CaM-bind-GEF 1 0.0026526 1 \ "" white blue 62.486 21.679 0 simundump kpool /kinetics/chain/kinetics[14]/Ras/CaM-GEF 1 -1e-12 0.00021398 \ 0.00021398 16.133 16.133 0 0 75396 0 /kinetics/dendgeom pink blue 65.345 \ 19.58 0 simundump kenz 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27.397 0 simundump kpool /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 1 -1e-12 1.2616e-05 \ 1.2616e-05 0.95122 0.95122 0 0 75396 0 /kinetics/dendgeom blue blue 58 24 0 simundump kreac /kinetics/chain/kinetics[14]/CaM/CaM-Ca4/diff 0 0.101 0.001 \ "" white black 59 27 0 simundump kreac /kinetics/chain/kinetics[14]/CaM/CaM-bind-Ca 1 0.00011254 \ 8.4853 "" white blue 50 30 0 simundump kpool /kinetics/chain/kinetics[14]/CaM/CaM-Ca2 1 -1e-12 0.11776 \ 0.11776 8878.5 8878.5 0 0 75396 0 /kinetics/dendgeom pink blue 54.999 \ 27.258 0 simundump kreac /kinetics/chain/kinetics[14]/CaM/CaM-Ca2/diff 0 0.101 0.001 \ "" white black 55.999 30.258 0 simundump kreac /kinetics/chain/kinetics[14]/CaM/CaM-Ca2-bind-Ca 1 4.7748e-05 \ 10 "" white blue 51.158 26.225 0 simundump kreac /kinetics/chain/kinetics[14]/CaM/CaM-Ca-bind-Ca 1 0.00011254 \ 8.4853 "" white blue 56 30 0 simundump kpool /kinetics/chain/kinetics[14]/CaM/CaM-Ca 1 -1e-12 1.472 1.472 \ 1.1098e+05 1.1098e+05 0 0 75396 0 /kinetics/dendgeom pink blue 53 31 0 simundump kreac /kinetics/chain/kinetics[14]/CaM/CaM-Ca/diff 0 0.101 0.001 "" \ white black 54 34 0 simundump kpool /kinetics/chain/kinetics[14]/Ca 1 -1e-12 0.08 0.08 6031.7 \ 6031.7 0 0 75396 0 /kinetics/dendgeom red black 42 23 0 simundump kreac /kinetics/chain/kinetics[14]/Ca/diff 0 0.101 0.001 "" white \ black 43 26 0 simundump kreac /kinetics/chain/kinetics[14]/Ras-act-unphosph-raf 0 0 0 "" \ white black 64 8 0 simundump group /kinetics/chain/kinetics[14]/PKM 0 25 black x 0 0 "" PKM \ defaultfile.g 0 5dc016e940e88c1cc7928f4e096ff523 0 53 19 0 simundump kpool /kinetics/chain/kinetics[14]/PKM/Ca_detector 0 -1e-12 0.99987 \ 0.99987 75386 75386 0 0 75396 0 /kinetics/dendgeom 7 25 49 17 0 simundump kreac /kinetics/chain/kinetics[14]/PKM/Ca_detector/diff 0 0.101 \ 0.001 "" white black 50 20 0 simundump kpool /kinetics/chain/kinetics[14]/PKM/PKM_synthesis 0 -1e-12 \ 0.0010085 0.0010085 76.04 76.04 0 0 75396 0 /kinetics/dendgeom 8 25 49 9 0 simundump kenz 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simundump kpool /kinetics/chain/kinetics[15]/PKC/PKC-Ca 0 -1e-12 0.078942 \ 0.078942 5951.9 5951.9 0 0 75396 0 /kinetics/dendgeom red black 59.925 \ 1.5108 0 simundump kreac /kinetics/chain/kinetics[15]/PKC/PKC-Ca/diff 0 0.101 0.001 "" \ white black 60.925 4.5108 0 simundump kreac /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 59.925 -0.12295 0 simundump kreac /kinetics/chain/kinetics[15]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 61.939 0.69395 0 simundump kreac /kinetics/chain/kinetics[15]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 60.203 4.2533 0 simundump kreac /kinetics/chain/kinetics[15]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 61.383 2.7362 0 simundump kpool /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb* 0 -1e-12 \ 0.028634 0.028634 2158.9 2158.9 0 0 75396 0 /kinetics/dendgeom pink blue \ 61.221 6.529 0 simundump kreac /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb*/diff 0 0.101 \ 0.001 "" white black 62.221 9.529 0 simundump 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\ 0.8223 0.8223 61998 61998 0 0 75396 0 /kinetics/dendgeom white blue 57.868 \ 0.59711 0 simundump kreac /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic/diff 0 0.101 \ 0.001 "" white black 58.868 3.5971 0 simundump kpool /kinetics/chain/kinetics[15]/PKC/PKM-zeta 0 -1e-12 0.01007 \ 0.01007 759.21 759.21 0 0 75396 0 /kinetics/dendgeom cyan blue 61 11 0 simundump kreac /kinetics/chain/kinetics[15]/PKC/PKM-zeta/diff 0 0.101 0.001 \ "" white black 62 14 0 simundump kpool /kinetics/chain/kinetics[15]/DAG 1 -1e-12 12.2 12.2 \ 9.1983e+05 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 68 -3 0 simundump kpool /kinetics/chain/kinetics[15]/PKC-active 1 -1e-12 0.047627 \ 0.047626 3590.8 3590.9 0 0 75396 2 /kinetics/dendgeom red black 64 9 0 simundump kenz /kinetics/chain/kinetics[15]/PKC-active/PKC-act-raf 1 \ 0.0011493 0.0011493 86.652 86.652 75396 1.3263e-05 16 4 0 0 "" red yellow \ "" 70 10 0 simundump kenz /kinetics/chain/kinetics[15]/PKC-active/PKC-inact-GAP 1 53.939 \ 53.939 6.778 6.778 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 68 13 0 simundump kenz /kinetics/chain/kinetics[15]/PKC-active/PKC-act-GEF 1 726.99 \ 726.99 91.354 91.354 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 73 20 0 simundump kpool /kinetics/chain/kinetics[15]/MAPK* 1 -1e-12 7.8539e-05 \ 7.8539e-05 5.9215 5.9215 0 0 75396 0 /kinetics/dendgeom orange yellow 77 1 \ 0 simundump kenz /kinetics/chain/kinetics[15]/MAPK*/MAPK*-feedback 1 3.6779e-08 \ 3.6779e-08 0.002773 0.002773 75396 2.5864e-05 40 10 0 0 "" red orange "" 74 \ 10 0 simundump kreac /kinetics/chain/kinetics[15]/MAPK*/diff 0 0.101 0.001 "" \ white black 78 4 0 simundump group /kinetics/chain/kinetics[15]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 79 11 0 simundump kpool /kinetics/chain/kinetics[15]/MAPK/craf-1 0 0 0.48263 0.48263 \ 36388 36388 0 0 75396 0 /kinetics/dendgeom pink brown 70 8 0 simundump kreac /kinetics/chain/kinetics[15]/MAPK/craf-1/diff 0 0.101 0.001 \ "" white black 71 11 0 simundump kpool 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0.79287 0.79287 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" \ 75 5 0 simundump kreac /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/diff 0 0.101 \ 0.001 "" white black 70 8 0 simundump kpool /kinetics/chain/kinetics[15]/MKP-1 1 -1e-12 0.019951 0.019951 \ 1504.2 1504.2 0 0 75396 0 /kinetics/dendgeom hotpink black 69 2 0 simundump kenz /kinetics/chain/kinetics[15]/MKP-1/MKP1-tyr-deph 1 4.781e-05 \ 4.781e-05 3.6047 3.6047 75396 3.7895e-05 16 4 0 0 "" red hotpink "" 70 3 0 simundump kenz /kinetics/chain/kinetics[15]/MKP-1/MKP1-thr-deph 1 2.2386e-07 \ 2.2386e-07 0.016878 0.016878 75396 3.7895e-05 16 4 0 0 "" red hotpink "" 75 \ 3 0 simundump kreac /kinetics/chain/kinetics[15]/MKP-1/diff 0 0.101 0.001 "" \ white black 70 5 0 simundump kreac /kinetics/chain/kinetics[15]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 67 9 0 simundump kpool /kinetics/chain/kinetics[15]/PPhosphatase2A 1 -1e-12 0.9991 \ 0.9991 75328 75328 0 0 75396 0 /kinetics/dendgeom hotpink yellow 73 9 0 simundump kenz /kinetics/chain/kinetics[15]/PPhosphatase2A/craf-deph 1 \ 0.00076621 0.00076621 57.769 57.769 75396 2.5414e-05 24 6 0 0 "" red \ hotpink "" 72 10 0 simundump kenz /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph 1 \ 5.2573e-07 5.2573e-07 0.039638 0.039638 75396 2.5414e-05 24 6 0 0 "" red \ hotpink "" 75 7 0 simundump kenz /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph-ser 1 \ 0.00012882 0.00012882 9.7128 9.7128 75396 2.5414e-05 24 6 0 0 "" red \ hotpink "" 72 7 0 simundump kenz /kinetics/chain/kinetics[15]/PPhosphatase2A/craf**-deph 1 \ 0.036779 0.036779 0.0046216 0.0046216 0.12566 2.5414e-05 24 6 0 0 "" red \ hotpink "" 76 10 0 simundump kreac /kinetics/chain/kinetics[15]/PPhosphatase2A/diff 0 0.101 \ 0.001 "" white black 74 12 0 simundump group /kinetics/chain/kinetics[15]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 78.513 16.351 0 simundump kreac /kinetics/chain/kinetics[15]/Ras/dephosph-GEF 1 1 0 "" white \ blue 73.07 17.881 0 simundump kpool 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orange blue 76.564 \ 13.084 0 simundump kreac /kinetics/chain/kinetics[15]/Ras/GTP-Ras/diff 0 0.101 0.001 \ "" white black 77.564 16.084 0 simundump kpool /kinetics/chain/kinetics[15]/Ras/GDP-Ras 1 0 0.48419 0.48419 \ 36506 36506 0 0 75396 0 /kinetics/dendgeom pink blue 70.131 14.165 0 simundump kreac /kinetics/chain/kinetics[15]/Ras/GDP-Ras/diff 0 0.101 0.001 \ "" white black 71.131 17.165 0 simundump kreac /kinetics/chain/kinetics[15]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 73.098 13.5 0 simundump kreac /kinetics/chain/kinetics[15]/Ras/dephosph-GAP 1 0.1 0 "" \ white blue 68.023 15.524 0 simundump kpool /kinetics/chain/kinetics[15]/Ras/GAP* 1 -1e-12 0.0035959 \ 0.0035959 271.12 271.12 0 0 75396 0 /kinetics/dendgeom red blue 65.35 \ 14.349 0 simundump kreac /kinetics/chain/kinetics[15]/Ras/GAP*/diff 0 0.101 0.001 "" \ white black 66.35 17.349 0 simundump kpool /kinetics/chain/kinetics[15]/Ras/GAP 1 -1e-12 0.0062918 \ 0.0062918 474.38 474.38 0 0 75396 0 /kinetics/dendgeom red blue 70.655 \ 12.338 0 simundump kenz /kinetics/chain/kinetics[15]/Ras/GAP/GAP-inact-ras 1 \ 2.1491e-05 2.1491e-05 1.6203 1.6203 75396 0.00065634 40 10 0 0 "" red red \ "" 73.012 12.403 0 simundump kreac /kinetics/chain/kinetics[15]/Ras/GAP/diff 0 0.101 0.001 "" \ white black 71.655 15.338 0 simundump kreac /kinetics/chain/kinetics[15]/Ras/CaM-bind-GEF 1 0.0026526 1 \ "" white blue 66.486 21.679 0 simundump kpool /kinetics/chain/kinetics[15]/Ras/CaM-GEF 1 -1e-12 0.00021398 \ 0.00021398 16.133 16.133 0 0 75396 0 /kinetics/dendgeom pink blue 69.345 \ 19.58 0 simundump kenz /kinetics/chain/kinetics[15]/Ras/CaM-GEF/CaM-GEF-act-ras 1 \ 0.00020513 0.00020513 15.466 15.466 75396 2.6261e-05 0.8 0.2 0 0 "" red \ pink "" 69.022 18.657 0 simundump kreac /kinetics/chain/kinetics[15]/Ras/CaM-GEF/diff 0 0.101 0.001 \ "" white black 70.345 22.58 0 simundump group /kinetics/chain/kinetics[15]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 54 21 0 simundump kpool 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12 0 simundump kreac /kinetics/chain/kinetics[15]/PKM/PKM_degradation 0 0.0005 0 \ "" white 25 56 7 0 simundump kpool /kinetics/chain/kinetics[15]/PKM/degraded_PKM 0 -1e-12 0 0 0 \ 0 0 0 75396 4 /kinetics/dendgeom 7 25 52 5 0 simundump kpool /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex 0 -1e-12 \ 0.00012615 0.00012615 9.5109 9.5109 0 0 75396 0 /kinetics/dendgeom 7 25 52 \ 14 0 simundump kenz /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex/kenz 0 \ 5.0428e-06 5.0428e-06 0.38021 0.38021 75396 2.6526e-06 0.8 0.2 0 0 "" red 7 \ "" 52 13 0 simundump kreac /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex/diff 0 \ 0.101 0.001 "" white black 53 17 0 simundump kpool /kinetics/chain/kinetics[15]/PKM/PKM_activator 0 -1e-12 \ 0.19988 0.19988 15070 15070 0 0 75396 0 /kinetics/dendgeom 6 25 49 12 0 simundump kreac /kinetics/chain/kinetics[15]/PKM/PKM_activator/diff 0 0.101 \ 0.001 "" white black 50 15 0 simundump kreac /kinetics/chain/kinetics[15]/PKM/turn_off_activator 0 0.001 0 \ "" white 25 47 9 0 simundump kreac /kinetics/chain/kinetics[15]/PKM/trigger_PKM 0 0.00013263 1 \ "" white 25 47 16 0 simundump kpool /kinetics/chain/kinetics[15]/Ca_input 0 0 0.08 0.08 6031.7 \ 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 46 30 0 simundump kreac /kinetics/chain/kinetics[15]/Ca_diff 0 5 5 "" white black 46 \ 26 0 simundump group /kinetics/chain/kinetics[16] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 68 0 0 simundump group /kinetics/chain/kinetics[16]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 64.951 8.2163 0 simundump kpool /kinetics/chain/kinetics[16]/PKC/PKC-Ca 0 -1e-12 0.078942 \ 0.078942 5951.9 5951.9 0 0 75396 0 /kinetics/dendgeom red black 63.925 \ 1.5108 0 simundump kreac /kinetics/chain/kinetics[16]/PKC/PKC-Ca/diff 0 0.101 0.001 "" \ white black 64.925 4.5108 0 simundump kreac /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 63.925 -0.12295 0 simundump kreac 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kreac /kinetics/chain/kinetics[16]/MAPK/MAPKK/diff 0 0.101 0.001 "" \ white black 75 7 0 simundump kpool /kinetics/chain/kinetics[16]/MAPK/MAPK 0 -1e-12 3.5824 3.5824 \ 2.701e+05 2.701e+05 0 0 75396 0 /kinetics/dendgeom pink brown 74 1 0 simundump kreac /kinetics/chain/kinetics[16]/MAPK/MAPK/diff 0 0.101 0.001 "" \ white black 75 4 0 simundump kpool /kinetics/chain/kinetics[16]/MAPK/craf-1** 1 0 9.6059e-07 \ 9.6059e-07 0.072425 0.072425 0 0 75396 0 /kinetics/dendgeom hotpink brown \ 80 8 0 simundump kreac /kinetics/chain/kinetics[16]/MAPK/craf-1**/diff 0 0.101 0.001 \ "" white black 81 11 0 simundump kpool /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr 1 -1e-12 0.016774 \ 0.016774 1264.7 1264.7 0 0 75396 0 /kinetics/dendgeom orange brown 77 1 0 simundump kreac /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr/diff 0 0.101 0.001 \ "" white black 78 4 0 simundump kpool /kinetics/chain/kinetics[16]/MAPK/MAPKK* 0 0 8.2386e-06 \ 8.2386e-06 0.62116 0.62116 0 0 75396 0 /kinetics/dendgeom pink brown 81 4 0 simundump kenz /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKtyr 0 0.00063751 \ 0.00063751 48.066 48.066 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 76 3 0 simundump kenz /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKthr 1 2.985e-06 \ 2.985e-06 0.22506 0.22506 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 81 3 \ 0 simundump kreac /kinetics/chain/kinetics[16]/MAPK/MAPKK*/diff 0 0.101 0.001 \ "" white black 82 7 0 simundump kpool /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser 1 0 0.0020188 \ 0.0020188 152.21 152.21 0 0 75396 0 /kinetics/dendgeom pink brown 77 4 0 simundump kreac /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser/diff 0 0.101 \ 0.001 "" white black 78 7 0 simundump kpool /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 73 6 0 simundump kenz /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 76 6 0 simundump kenz 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simundump kreac /kinetics/chain/kinetics[16]/Ras/CaM-bind-GEF 1 0.0026526 1 \ "" white blue 70.486 21.679 0 simundump kpool /kinetics/chain/kinetics[16]/Ras/CaM-GEF 1 -1e-12 0.00021398 \ 0.00021398 16.133 16.133 0 0 75396 0 /kinetics/dendgeom pink blue 73.345 \ 19.58 0 simundump kenz /kinetics/chain/kinetics[16]/Ras/CaM-GEF/CaM-GEF-act-ras 1 \ 0.00020513 0.00020513 15.466 15.466 75396 2.6261e-05 0.8 0.2 0 0 "" red \ pink "" 73.022 18.657 0 simundump kreac /kinetics/chain/kinetics[16]/Ras/CaM-GEF/diff 0 0.101 0.001 \ "" white black 74.345 22.58 0 simundump group /kinetics/chain/kinetics[16]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 58 21 0 simundump kpool /kinetics/chain/kinetics[16]/CaM/CaM 1 -1e-12 18.403 18.403 \ 1.3875e+06 1.3875e+06 0 0 75396 0 /kinetics/dendgeom pink blue 55 30 0 simundump kreac /kinetics/chain/kinetics[16]/CaM/CaM/diff 0 0.101 0.001 "" \ white black 56 33 0 simundump kreac /kinetics/chain/kinetics[16]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" 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0 simundump group /kinetics/chain/kinetics[17]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 86.513 16.351 0 simundump kreac /kinetics/chain/kinetics[17]/Ras/dephosph-GEF 1 1 0 "" white \ blue 81.07 17.881 0 simundump kpool /kinetics/chain/kinetics[17]/Ras/inact-GEF 1 -1e-12 0.084803 \ 0.084803 6393.8 6393.8 0 0 75396 0 /kinetics/dendgeom hotpink blue 84.453 \ 18.352 0 simundump kenz /kinetics/chain/kinetics[17]/Ras/inact-GEF/basal_GEF_activity 0 \ 0.0040648 0.0040648 306.47 306.47 75396 1.313e-07 0.08 0.02 0 0 "" red \ hotpink "" 84 17 0 simundump kreac /kinetics/chain/kinetics[17]/Ras/inact-GEF/diff 0 0.101 0.001 \ "" white black 85.453 21.352 0 simundump kpool /kinetics/chain/kinetics[17]/Ras/GEF* 1 -1e-12 0.0048465 \ 0.0048465 365.41 365.41 0 0 75396 0 /kinetics/dendgeom hotpink blue 78.448 \ 17.246 0 simundump kenz /kinetics/chain/kinetics[17]/Ras/GEF*/GEF*-act-ras 1 0.0046465 \ 0.0046465 350.33 350.33 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" \ 79.086 16.086 0 simundump kreac /kinetics/chain/kinetics[17]/Ras/GEF*/diff 0 0.101 0.001 "" \ white black 79.448 20.246 0 simundump kpool /kinetics/chain/kinetics[17]/Ras/GTP-Ras 1 0 0.0034512 \ 0.0034512 260.21 260.21 0 0 75396 0 /kinetics/dendgeom orange blue 84.564 \ 13.084 0 simundump kreac /kinetics/chain/kinetics[17]/Ras/GTP-Ras/diff 0 0.101 0.001 \ "" white black 85.564 16.084 0 simundump kpool /kinetics/chain/kinetics[17]/Ras/GDP-Ras 1 0 0.48419 0.48419 \ 36506 36506 0 0 75396 0 /kinetics/dendgeom pink blue 78.131 14.165 0 simundump kreac /kinetics/chain/kinetics[17]/Ras/GDP-Ras/diff 0 0.101 0.001 \ "" white black 79.131 17.165 0 simundump kreac /kinetics/chain/kinetics[17]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 81.098 13.5 0 simundump kreac /kinetics/chain/kinetics[17]/Ras/dephosph-GAP 1 0.1 0 "" \ white blue 76.023 15.524 0 simundump kpool /kinetics/chain/kinetics[17]/Ras/GAP* 1 -1e-12 0.0035959 \ 0.0035959 271.12 271.12 0 0 75396 0 /kinetics/dendgeom red blue 73.35 \ 14.349 0 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/kinetics/chain/kinetics[17]/Ras/CaM-GEF/diff 0 0.101 0.001 \ "" white black 78.345 22.58 0 simundump group /kinetics/chain/kinetics[17]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 62 21 0 simundump kpool /kinetics/chain/kinetics[17]/CaM/CaM 1 -1e-12 18.403 18.403 \ 1.3875e+06 1.3875e+06 0 0 75396 0 /kinetics/dendgeom pink blue 59 30 0 simundump kreac /kinetics/chain/kinetics[17]/CaM/CaM/diff 0 0.101 0.001 "" \ white black 60 33 0 simundump kreac /kinetics/chain/kinetics[17]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 61.6 23.26 0 simundump kpool /kinetics/chain/kinetics[17]/CaM/CaM-Ca3 1 -1e-12 0.0033914 \ 0.0033914 255.7 255.7 0 0 75396 0 /kinetics/dendgeom hotpink blue 65.489 \ 24.397 0 simundump kreac /kinetics/chain/kinetics[17]/CaM/CaM-Ca3/diff 0 0.101 0.001 \ "" white black 66.489 27.397 0 simundump kpool /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 1 -1e-12 1.2616e-05 \ 1.2616e-05 0.95122 0.95122 0 0 75396 0 /kinetics/dendgeom blue blue 70 24 0 simundump 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4 0 0 "" red yellow "" 85 20 0 simundump kpool /kinetics/chain/kinetics[18]/MAPK* 1 -1e-12 7.8539e-05 \ 7.8539e-05 5.9215 5.9215 0 0 75396 0 /kinetics/dendgeom orange yellow 89 1 \ 0 simundump kenz /kinetics/chain/kinetics[18]/MAPK*/MAPK*-feedback 1 3.6779e-08 \ 3.6779e-08 0.002773 0.002773 75396 2.5864e-05 40 10 0 0 "" red orange "" 86 \ 10 0 simundump kreac /kinetics/chain/kinetics[18]/MAPK*/diff 0 0.101 0.001 "" \ white black 90 4 0 simundump group /kinetics/chain/kinetics[18]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 91 11 0 simundump kpool /kinetics/chain/kinetics[18]/MAPK/craf-1 0 0 0.48263 0.48263 \ 36388 36388 0 0 75396 0 /kinetics/dendgeom pink brown 82 8 0 simundump kreac /kinetics/chain/kinetics[18]/MAPK/craf-1/diff 0 0.101 0.001 \ "" white black 83 11 0 simundump kpool /kinetics/chain/kinetics[18]/MAPK/craf-1* 0 0 0.012007 \ 0.012007 905.28 905.28 0 0 75396 0 /kinetics/dendgeom pink brown 85 8 0 simundump kreac 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3.7895e-05 16 4 0 0 "" red hotpink "" 91 \ 3 0 simundump kreac /kinetics/chain/kinetics[19]/MKP-1/diff 0 0.101 0.001 "" \ white black 86 5 0 simundump kreac /kinetics/chain/kinetics[19]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 83 9 0 simundump kpool /kinetics/chain/kinetics[19]/PPhosphatase2A 1 -1e-12 0.9991 \ 0.9991 75328 75328 0 0 75396 0 /kinetics/dendgeom hotpink yellow 89 9 0 simundump kenz /kinetics/chain/kinetics[19]/PPhosphatase2A/craf-deph 1 \ 0.00076621 0.00076621 57.769 57.769 75396 2.5414e-05 24 6 0 0 "" red \ hotpink "" 88 10 0 simundump kenz /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph 1 \ 5.2573e-07 5.2573e-07 0.039638 0.039638 75396 2.5414e-05 24 6 0 0 "" red \ hotpink "" 91 7 0 simundump kenz /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph-ser 1 \ 0.00012882 0.00012882 9.7128 9.7128 75396 2.5414e-05 24 6 0 0 "" red \ hotpink "" 88 7 0 simundump kenz /kinetics/chain/kinetics[19]/PPhosphatase2A/craf**-deph 1 \ 0.036779 0.036779 0.0046216 0.0046216 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0 simundump kpool /kinetics/chain/kinetics[19]/Ras/GAP* 1 -1e-12 0.0035959 \ 0.0035959 271.12 271.12 0 0 75396 0 /kinetics/dendgeom red blue 81.35 \ 14.349 0 simundump kreac /kinetics/chain/kinetics[19]/Ras/GAP*/diff 0 0.101 0.001 "" \ white black 82.35 17.349 0 simundump kpool /kinetics/chain/kinetics[19]/Ras/GAP 1 -1e-12 0.0062918 \ 0.0062918 474.38 474.38 0 0 75396 0 /kinetics/dendgeom red blue 86.655 \ 12.338 0 simundump kenz /kinetics/chain/kinetics[19]/Ras/GAP/GAP-inact-ras 1 \ 2.1491e-05 2.1491e-05 1.6203 1.6203 75396 0.00065634 40 10 0 0 "" red red \ "" 89.012 12.403 0 simundump kreac /kinetics/chain/kinetics[19]/Ras/GAP/diff 0 0.101 0.001 "" \ white black 87.655 15.338 0 simundump kreac /kinetics/chain/kinetics[19]/Ras/CaM-bind-GEF 1 0.0026526 1 \ "" white blue 82.486 21.679 0 simundump kpool /kinetics/chain/kinetics[19]/Ras/CaM-GEF 1 -1e-12 0.00021398 \ 0.00021398 16.133 16.133 0 0 75396 0 /kinetics/dendgeom pink blue 85.345 \ 19.58 0 simundump kenz 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27.397 0 simundump kpool /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 1 -1e-12 1.2616e-05 \ 1.2616e-05 0.95122 0.95122 0 0 75396 0 /kinetics/dendgeom blue blue 78 24 0 simundump kreac /kinetics/chain/kinetics[19]/CaM/CaM-Ca4/diff 0 0.101 0.001 \ "" white black 79 27 0 simundump kreac /kinetics/chain/kinetics[19]/CaM/CaM-bind-Ca 1 0.00011254 \ 8.4853 "" white blue 70 30 0 simundump kpool /kinetics/chain/kinetics[19]/CaM/CaM-Ca2 1 -1e-12 0.11776 \ 0.11776 8878.5 8878.5 0 0 75396 0 /kinetics/dendgeom pink blue 74.999 \ 27.258 0 simundump kreac /kinetics/chain/kinetics[19]/CaM/CaM-Ca2/diff 0 0.101 0.001 \ "" white black 75.999 30.258 0 simundump kreac /kinetics/chain/kinetics[19]/CaM/CaM-Ca2-bind-Ca 1 4.7748e-05 \ 10 "" white blue 71.158 26.225 0 simundump kreac /kinetics/chain/kinetics[19]/CaM/CaM-Ca-bind-Ca 1 0.00011254 \ 8.4853 "" white blue 76 30 0 simundump kpool /kinetics/chain/kinetics[19]/CaM/CaM-Ca 1 -1e-12 1.472 1.472 \ 1.1098e+05 1.1098e+05 0 0 75396 0 /kinetics/dendgeom pink blue 73 31 0 simundump kreac /kinetics/chain/kinetics[19]/CaM/CaM-Ca/diff 0 0.101 0.001 "" \ white black 74 34 0 simundump kpool /kinetics/chain/kinetics[19]/Ca 1 -1e-12 0.08 0.08 6031.7 \ 6031.7 0 0 75396 0 /kinetics/dendgeom red black 62 23 0 simundump kreac /kinetics/chain/kinetics[19]/Ca/diff 0 0.101 0.001 "" white \ black 63 26 0 simundump kreac /kinetics/chain/kinetics[19]/Ras-act-unphosph-raf 0 0 0 "" \ white black 84 8 0 simundump group /kinetics/chain/kinetics[19]/PKM 0 25 black x 0 0 "" PKM \ defaultfile.g 0 5dc016e940e88c1cc7928f4e096ff523 0 73 19 0 simundump kpool /kinetics/chain/kinetics[19]/PKM/Ca_detector 0 -1e-12 0.99987 \ 0.99987 75386 75386 0 0 75396 0 /kinetics/dendgeom 7 25 69 17 0 simundump kreac /kinetics/chain/kinetics[19]/PKM/Ca_detector/diff 0 0.101 \ 0.001 "" white black 70 20 0 simundump kpool /kinetics/chain/kinetics[19]/PKM/PKM_synthesis 0 -1e-12 \ 0.0010085 0.0010085 76.04 76.04 0 0 75396 0 /kinetics/dendgeom 8 25 69 9 0 simundump kenz 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simundump kpool /kinetics/chain/kinetics[20]/PKC/PKC-Ca 0 -1e-12 0.078942 \ 0.078942 5951.9 5951.9 0 0 75396 0 /kinetics/dendgeom red black 79.925 \ 1.5108 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-Ca/diff 0 0.101 0.001 "" \ white black 80.925 4.5108 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 79.925 -0.12295 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 81.939 0.69395 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 80.203 4.2533 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 81.383 2.7362 0 simundump kpool /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb* 0 -1e-12 \ 0.028634 0.028634 2158.9 2158.9 0 0 75396 0 /kinetics/dendgeom pink blue \ 81.221 6.529 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb*/diff 0 0.101 \ 0.001 "" white black 82.221 9.529 0 simundump 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\ 0.8223 0.8223 61998 61998 0 0 75396 0 /kinetics/dendgeom white blue 77.868 \ 0.59711 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic/diff 0 0.101 \ 0.001 "" white black 78.868 3.5971 0 simundump kpool /kinetics/chain/kinetics[20]/PKC/PKM-zeta 0 -1e-12 0.01007 \ 0.01007 759.21 759.21 0 0 75396 0 /kinetics/dendgeom cyan blue 81 11 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKM-zeta/diff 0 0.101 0.001 \ "" white black 82 14 0 simundump kpool /kinetics/chain/kinetics[20]/DAG 1 -1e-12 12.2 12.2 \ 9.1983e+05 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 88 -3 0 simundump kpool /kinetics/chain/kinetics[20]/PKC-active 1 -1e-12 0.047627 \ 0.047626 3590.8 3590.9 0 0 75396 2 /kinetics/dendgeom red black 84 9 0 simundump kenz /kinetics/chain/kinetics[20]/PKC-active/PKC-act-raf 1 \ 0.0011493 0.0011493 86.652 86.652 75396 1.3263e-05 16 4 0 0 "" red yellow \ "" 90 10 0 simundump kenz /kinetics/chain/kinetics[20]/PKC-active/PKC-inact-GAP 1 53.939 \ 53.939 6.778 6.778 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 88 13 0 simundump kenz /kinetics/chain/kinetics[20]/PKC-active/PKC-act-GEF 1 726.99 \ 726.99 91.354 91.354 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 93 20 0 simundump kpool /kinetics/chain/kinetics[20]/MAPK* 1 -1e-12 7.8539e-05 \ 7.8539e-05 5.9215 5.9215 0 0 75396 0 /kinetics/dendgeom orange yellow 97 1 \ 0 simundump kenz /kinetics/chain/kinetics[20]/MAPK*/MAPK*-feedback 1 3.6779e-08 \ 3.6779e-08 0.002773 0.002773 75396 2.5864e-05 40 10 0 0 "" red orange "" 94 \ 10 0 simundump kreac /kinetics/chain/kinetics[20]/MAPK*/diff 0 0.101 0.001 "" \ white black 98 4 0 simundump group /kinetics/chain/kinetics[20]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 99 11 0 simundump kpool /kinetics/chain/kinetics[20]/MAPK/craf-1 0 0 0.48263 0.48263 \ 36388 36388 0 0 75396 0 /kinetics/dendgeom pink brown 90 8 0 simundump kreac /kinetics/chain/kinetics[20]/MAPK/craf-1/diff 0 0.101 0.001 \ "" white black 91 11 0 simundump kpool 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0.79287 0.79287 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" \ 95 5 0 simundump kreac /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/diff 0 0.101 \ 0.001 "" white black 90 8 0 simundump kpool /kinetics/chain/kinetics[20]/MKP-1 1 -1e-12 0.019951 0.019951 \ 1504.2 1504.2 0 0 75396 0 /kinetics/dendgeom hotpink black 89 2 0 simundump kenz /kinetics/chain/kinetics[20]/MKP-1/MKP1-tyr-deph 1 4.781e-05 \ 4.781e-05 3.6047 3.6047 75396 3.7895e-05 16 4 0 0 "" red hotpink "" 90 3 0 simundump kenz /kinetics/chain/kinetics[20]/MKP-1/MKP1-thr-deph 1 2.2386e-07 \ 2.2386e-07 0.016878 0.016878 75396 3.7895e-05 16 4 0 0 "" red hotpink "" 95 \ 3 0 simundump kreac /kinetics/chain/kinetics[20]/MKP-1/diff 0 0.101 0.001 "" \ white black 90 5 0 simundump kreac /kinetics/chain/kinetics[20]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 87 9 0 simundump kpool /kinetics/chain/kinetics[20]/PPhosphatase2A 1 -1e-12 0.9991 \ 0.9991 75328 75328 0 0 75396 0 /kinetics/dendgeom hotpink yellow 93 9 0 simundump kenz /kinetics/chain/kinetics[20]/PPhosphatase2A/craf-deph 1 \ 0.00076621 0.00076621 57.769 57.769 75396 2.5414e-05 24 6 0 0 "" red \ hotpink "" 92 10 0 simundump kenz /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph 1 \ 5.2573e-07 5.2573e-07 0.039638 0.039638 75396 2.5414e-05 24 6 0 0 "" red \ hotpink "" 95 7 0 simundump kenz /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph-ser 1 \ 0.00012882 0.00012882 9.7128 9.7128 75396 2.5414e-05 24 6 0 0 "" red \ hotpink "" 92 7 0 simundump kenz /kinetics/chain/kinetics[20]/PPhosphatase2A/craf**-deph 1 \ 0.036779 0.036779 0.0046216 0.0046216 0.12566 2.5414e-05 24 6 0 0 "" red \ hotpink "" 96 10 0 simundump kreac /kinetics/chain/kinetics[20]/PPhosphatase2A/diff 0 0.101 \ 0.001 "" white black 94 12 0 simundump group /kinetics/chain/kinetics[20]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 98.513 16.351 0 simundump kreac /kinetics/chain/kinetics[20]/Ras/dephosph-GEF 1 1 0 "" white \ blue 93.07 17.881 0 simundump kpool /kinetics/chain/kinetics[20]/Ras/inact-GEF 1 -1e-12 0.084803 \ 0.084803 6393.8 6393.8 0 0 75396 0 /kinetics/dendgeom hotpink blue 96.453 \ 18.352 0 simundump kenz /kinetics/chain/kinetics[20]/Ras/inact-GEF/basal_GEF_activity 0 \ 0.0040648 0.0040648 306.47 306.47 75396 1.313e-07 0.08 0.02 0 0 "" red \ hotpink "" 96 17 0 simundump kreac /kinetics/chain/kinetics[20]/Ras/inact-GEF/diff 0 0.101 0.001 \ "" white black 97.453 21.352 0 simundump kpool /kinetics/chain/kinetics[20]/Ras/GEF* 1 -1e-12 0.0048465 \ 0.0048465 365.41 365.41 0 0 75396 0 /kinetics/dendgeom hotpink blue 90.448 \ 17.246 0 simundump kenz /kinetics/chain/kinetics[20]/Ras/GEF*/GEF*-act-ras 1 0.0046465 \ 0.0046465 350.33 350.33 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" \ 91.086 16.086 0 simundump kreac /kinetics/chain/kinetics[20]/Ras/GEF*/diff 0 0.101 0.001 "" \ white black 91.448 20.246 0 simundump kpool /kinetics/chain/kinetics[20]/Ras/GTP-Ras 1 0 0.0034512 \ 0.0034512 260.21 260.21 0 0 75396 0 /kinetics/dendgeom orange blue 96.564 \ 13.084 0 simundump kreac /kinetics/chain/kinetics[20]/Ras/GTP-Ras/diff 0 0.101 0.001 \ "" white black 97.564 16.084 0 simundump kpool /kinetics/chain/kinetics[20]/Ras/GDP-Ras 1 0 0.48419 0.48419 \ 36506 36506 0 0 75396 0 /kinetics/dendgeom pink blue 90.131 14.165 0 simundump kreac /kinetics/chain/kinetics[20]/Ras/GDP-Ras/diff 0 0.101 0.001 \ "" white black 91.131 17.165 0 simundump kreac /kinetics/chain/kinetics[20]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 93.098 13.5 0 simundump kreac /kinetics/chain/kinetics[20]/Ras/dephosph-GAP 1 0.1 0 "" \ white blue 88.023 15.524 0 simundump kpool /kinetics/chain/kinetics[20]/Ras/GAP* 1 -1e-12 0.0035959 \ 0.0035959 271.12 271.12 0 0 75396 0 /kinetics/dendgeom red blue 85.35 \ 14.349 0 simundump kreac /kinetics/chain/kinetics[20]/Ras/GAP*/diff 0 0.101 0.001 "" \ white black 86.35 17.349 0 simundump kpool /kinetics/chain/kinetics[20]/Ras/GAP 1 -1e-12 0.0062918 \ 0.0062918 474.38 474.38 0 0 75396 0 /kinetics/dendgeom red blue 90.655 \ 12.338 0 simundump kenz /kinetics/chain/kinetics[20]/Ras/GAP/GAP-inact-ras 1 \ 2.1491e-05 2.1491e-05 1.6203 1.6203 75396 0.00065634 40 10 0 0 "" red red \ "" 93.012 12.403 0 simundump kreac /kinetics/chain/kinetics[20]/Ras/GAP/diff 0 0.101 0.001 "" \ white black 91.655 15.338 0 simundump kreac /kinetics/chain/kinetics[20]/Ras/CaM-bind-GEF 1 0.0026526 1 \ "" white blue 86.486 21.679 0 simundump kpool /kinetics/chain/kinetics[20]/Ras/CaM-GEF 1 -1e-12 0.00021398 \ 0.00021398 16.133 16.133 0 0 75396 0 /kinetics/dendgeom pink blue 89.345 \ 19.58 0 simundump kenz /kinetics/chain/kinetics[20]/Ras/CaM-GEF/CaM-GEF-act-ras 1 \ 0.00020513 0.00020513 15.466 15.466 75396 2.6261e-05 0.8 0.2 0 0 "" red \ pink "" 89.022 18.657 0 simundump kreac /kinetics/chain/kinetics[20]/Ras/CaM-GEF/diff 0 0.101 0.001 \ "" white black 90.345 22.58 0 simundump group /kinetics/chain/kinetics[20]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 74 21 0 simundump kpool /kinetics/chain/kinetics[20]/CaM/CaM 1 -1e-12 18.403 18.403 \ 1.3875e+06 1.3875e+06 0 0 75396 0 /kinetics/dendgeom pink blue 71 30 0 simundump kreac /kinetics/chain/kinetics[20]/CaM/CaM/diff 0 0.101 0.001 "" \ white black 72 33 0 simundump kreac /kinetics/chain/kinetics[20]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 73.6 23.26 0 simundump kpool /kinetics/chain/kinetics[20]/CaM/CaM-Ca3 1 -1e-12 0.0033914 \ 0.0033914 255.7 255.7 0 0 75396 0 /kinetics/dendgeom hotpink blue 77.489 \ 24.397 0 simundump kreac /kinetics/chain/kinetics[20]/CaM/CaM-Ca3/diff 0 0.101 0.001 \ "" white black 78.489 27.397 0 simundump kpool /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 1 -1e-12 1.2616e-05 \ 1.2616e-05 0.95122 0.95122 0 0 75396 0 /kinetics/dendgeom blue blue 82 24 0 simundump kreac /kinetics/chain/kinetics[20]/CaM/CaM-Ca4/diff 0 0.101 0.001 \ "" white black 83 27 0 simundump kreac /kinetics/chain/kinetics[20]/CaM/CaM-bind-Ca 1 0.00011254 \ 8.4853 "" white blue 74 30 0 simundump kpool 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12 0 simundump kreac /kinetics/chain/kinetics[20]/PKM/PKM_degradation 0 0.0005 0 \ "" white 25 76 7 0 simundump kpool /kinetics/chain/kinetics[20]/PKM/degraded_PKM 0 -1e-12 0 0 0 \ 0 0 0 75396 4 /kinetics/dendgeom 7 25 72 5 0 simundump kpool /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex 0 -1e-12 \ 0.00012615 0.00012615 9.5109 9.5109 0 0 75396 0 /kinetics/dendgeom 7 25 72 \ 14 0 simundump kenz /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex/kenz 0 \ 5.0428e-06 5.0428e-06 0.38021 0.38021 75396 2.6526e-06 0.8 0.2 0 0 "" red 7 \ "" 72 13 0 simundump kreac /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex/diff 0 \ 0.101 0.001 "" white black 73 17 0 simundump kpool /kinetics/chain/kinetics[20]/PKM/PKM_activator 0 -1e-12 \ 0.19988 0.19988 15070 15070 0 0 75396 0 /kinetics/dendgeom 6 25 69 12 0 simundump kreac /kinetics/chain/kinetics[20]/PKM/PKM_activator/diff 0 0.101 \ 0.001 "" white black 70 15 0 simundump kreac /kinetics/chain/kinetics[20]/PKM/turn_off_activator 0 0.001 0 \ "" white 25 67 9 0 simundump kreac /kinetics/chain/kinetics[20]/PKM/trigger_PKM 0 0.00013263 1 \ "" white 25 67 16 0 simundump kpool /kinetics/chain/kinetics[20]/Ca_input 0 0 0.08 0.08 6031.7 \ 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 66 30 0 simundump kreac /kinetics/chain/kinetics[20]/Ca_diff 0 5 5 "" white black 66 \ 26 0 simundump group /kinetics/chain/kinetics[21] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 88 0 0 simundump group /kinetics/chain/kinetics[21]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 84.951 8.2163 0 simundump kpool /kinetics/chain/kinetics[21]/PKC/PKC-Ca 0 -1e-12 0.078942 \ 0.078942 5951.9 5951.9 0 0 75396 0 /kinetics/dendgeom red black 83.925 \ 1.5108 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-Ca/diff 0 0.101 0.001 "" \ white black 84.925 4.5108 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 83.925 -0.12295 0 simundump kreac 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/kinetics/dendgeom white \ blue 88.231 1.8026 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG/diff 0 0.101 \ 0.001 "" white black 89.231 4.8026 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 84.99 -1.9902 0 simundump kpool /kinetics/chain/kinetics[21]/PKC/PKC-DAG 0 -1e-12 0.060193 \ 0.060193 4538.3 4538.3 0 0 75396 0 /kinetics/dendgeom white blue 87.004 \ -1.0857 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-DAG/diff 0 0.101 0.001 \ "" white black 88.004 1.9143 0 simundump kpool /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic 0 -1e-12 \ 0.8223 0.8223 61998 61998 0 0 75396 0 /kinetics/dendgeom white blue 81.868 \ 0.59711 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic/diff 0 0.101 \ 0.001 "" white black 82.868 3.5971 0 simundump kpool /kinetics/chain/kinetics[21]/PKC/PKM-zeta 0 -1e-12 0.01007 \ 0.01007 759.21 759.21 0 0 75396 0 /kinetics/dendgeom cyan blue 85 11 0 simundump kreac 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kreac /kinetics/chain/kinetics[21]/MAPK/MAPKK/diff 0 0.101 0.001 "" \ white black 95 7 0 simundump kpool /kinetics/chain/kinetics[21]/MAPK/MAPK 0 -1e-12 3.5824 3.5824 \ 2.701e+05 2.701e+05 0 0 75396 0 /kinetics/dendgeom pink brown 94 1 0 simundump kreac /kinetics/chain/kinetics[21]/MAPK/MAPK/diff 0 0.101 0.001 "" \ white black 95 4 0 simundump kpool /kinetics/chain/kinetics[21]/MAPK/craf-1** 1 0 9.6059e-07 \ 9.6059e-07 0.072425 0.072425 0 0 75396 0 /kinetics/dendgeom hotpink brown \ 100 8 0 simundump kreac /kinetics/chain/kinetics[21]/MAPK/craf-1**/diff 0 0.101 0.001 \ "" white black 101 11 0 simundump kpool /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr 1 -1e-12 0.016774 \ 0.016774 1264.7 1264.7 0 0 75396 0 /kinetics/dendgeom orange brown 97 1 0 simundump kreac /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr/diff 0 0.101 0.001 \ "" white black 98 4 0 simundump kpool /kinetics/chain/kinetics[21]/MAPK/MAPKK* 0 0 8.2386e-06 \ 8.2386e-06 0.62116 0.62116 0 0 75396 0 /kinetics/dendgeom pink brown 101 4 \ 0 simundump kenz /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKtyr 0 0.00063751 \ 0.00063751 48.066 48.066 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 96 3 0 simundump kenz /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKthr 1 2.985e-06 \ 2.985e-06 0.22506 0.22506 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 101 3 \ 0 simundump kreac /kinetics/chain/kinetics[21]/MAPK/MAPKK*/diff 0 0.101 0.001 \ "" white black 102 7 0 simundump kpool /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser 1 0 0.0020188 \ 0.0020188 152.21 152.21 0 0 75396 0 /kinetics/dendgeom pink brown 97 4 0 simundump kreac /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser/diff 0 0.101 \ 0.001 "" white black 98 7 0 simundump kpool /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 93 6 0 simundump kenz /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 96 6 0 simundump kenz 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93.35 \ 14.349 0 simundump kreac /kinetics/chain/kinetics[22]/Ras/GAP*/diff 0 0.101 0.001 "" \ white black 94.35 17.349 0 simundump kpool /kinetics/chain/kinetics[22]/Ras/GAP 1 -1e-12 0.0062918 \ 0.0062918 474.38 474.38 0 0 75396 0 /kinetics/dendgeom red blue 98.655 \ 12.338 0 simundump kenz /kinetics/chain/kinetics[22]/Ras/GAP/GAP-inact-ras 1 \ 2.1491e-05 2.1491e-05 1.6203 1.6203 75396 0.00065634 40 10 0 0 "" red red \ "" 101.01 12.403 0 simundump kreac /kinetics/chain/kinetics[22]/Ras/GAP/diff 0 0.101 0.001 "" \ white black 99.655 15.338 0 simundump kreac /kinetics/chain/kinetics[22]/Ras/CaM-bind-GEF 1 0.0026526 1 \ "" white blue 94.486 21.679 0 simundump kpool /kinetics/chain/kinetics[22]/Ras/CaM-GEF 1 -1e-12 0.00021398 \ 0.00021398 16.133 16.133 0 0 75396 0 /kinetics/dendgeom pink blue 97.345 \ 19.58 0 simundump kenz /kinetics/chain/kinetics[22]/Ras/CaM-GEF/CaM-GEF-act-ras 1 \ 0.00020513 0.00020513 15.466 15.466 75396 2.6261e-05 0.8 0.2 0 0 "" red \ pink "" 97.022 18.657 0 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3.5824 \ 2.701e+05 2.701e+05 0 0 75396 0 /kinetics/dendgeom pink brown 106 1 0 simundump kreac /kinetics/chain/kinetics[24]/MAPK/MAPK/diff 0 0.101 0.001 "" \ white black 107 4 0 simundump kpool /kinetics/chain/kinetics[24]/MAPK/craf-1** 1 0 9.6059e-07 \ 9.6059e-07 0.072425 0.072425 0 0 75396 0 /kinetics/dendgeom hotpink brown \ 112 8 0 simundump kreac /kinetics/chain/kinetics[24]/MAPK/craf-1**/diff 0 0.101 0.001 \ "" white black 113 11 0 simundump kpool /kinetics/chain/kinetics[24]/MAPK/MAPK-tyr 1 -1e-12 0.016774 \ 0.016774 1264.7 1264.7 0 0 75396 0 /kinetics/dendgeom orange brown 109 1 0 simundump kreac /kinetics/chain/kinetics[24]/MAPK/MAPK-tyr/diff 0 0.101 0.001 \ "" white black 110 4 0 simundump kpool /kinetics/chain/kinetics[24]/MAPK/MAPKK* 0 0 8.2386e-06 \ 8.2386e-06 0.62116 0.62116 0 0 75396 0 /kinetics/dendgeom pink brown 113 4 \ 0 simundump kenz /kinetics/chain/kinetics[24]/MAPK/MAPKK*/MAPKKtyr 0 0.00063751 \ 0.00063751 48.066 48.066 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 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76.04 0 0 75396 0 /kinetics/dendgeom 8 25 89 9 0 simundump kenz /kinetics/chain/kinetics[24]/PKM/PKM_synthesis/kenz 0 \ 0.00010086 0.00010086 7.6041 7.6041 75396 3.3159e-07 0.2 0.05 0 0 "" red 8 \ "" 90 10 0 simundump kreac /kinetics/chain/kinetics[24]/PKM/PKM_synthesis/diff 0 0.101 \ 0.001 "" white black 90 12 0 simundump kpool /kinetics/chain/kinetics[24]/PKM/AA_pool 0 -1e-12 1 1 75396 \ 75396 0 0 75396 4 /kinetics/dendgeom 9 25 93 12 0 simundump kreac /kinetics/chain/kinetics[24]/PKM/PKM_degradation 0 0.0005 0 \ "" white 25 92 7 0 simundump kpool /kinetics/chain/kinetics[24]/PKM/degraded_PKM 0 -1e-12 0 0 0 \ 0 0 0 75396 4 /kinetics/dendgeom 7 25 88 5 0 simundump kpool /kinetics/chain/kinetics[24]/PKM/Ca.detector_complex 0 -1e-12 \ 0.00012615 0.00012615 9.5109 9.5109 0 0 75396 0 /kinetics/dendgeom 7 25 88 \ 14 0 simundump kenz /kinetics/chain/kinetics[24]/PKM/Ca.detector_complex/kenz 0 \ 5.0428e-06 5.0428e-06 0.38021 0.38021 75396 2.6526e-06 0.8 0.2 0 0 "" red 7 \ "" 88 13 0 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100.95 8.2163 0 simundump kpool /kinetics/chain/kinetics[25]/PKC/PKC-Ca 0 -1e-12 0.078942 \ 0.078942 5951.9 5951.9 0 0 75396 0 /kinetics/dendgeom red black 99.925 \ 1.5108 0 simundump kreac /kinetics/chain/kinetics[25]/PKC/PKC-Ca/diff 0 0.101 0.001 "" \ white black 100.93 4.5108 0 simundump kreac /kinetics/chain/kinetics[25]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 99.925 -0.12295 0 simundump kreac /kinetics/chain/kinetics[25]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 101.94 0.69395 0 simundump kreac /kinetics/chain/kinetics[25]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 100.2 4.2533 0 simundump kreac /kinetics/chain/kinetics[25]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 101.38 2.7362 0 simundump kpool /kinetics/chain/kinetics[25]/PKC/PKC-Ca-memb* 0 -1e-12 \ 0.028634 0.028634 2158.9 2158.9 0 0 75396 0 /kinetics/dendgeom pink blue \ 101.22 6.529 0 simundump kreac /kinetics/chain/kinetics[25]/PKC/PKC-Ca-memb*/diff 0 0.101 \ 0.001 "" white black 102.22 9.529 0 simundump kpool /kinetics/chain/kinetics[25]/PKC/PKC-DAG-memb* 0 -1e-12 \ 0.0089225 0.0089225 672.72 672.72 0 0 75396 0 /kinetics/dendgeom yellow \ blue 102.17 5.5078 0 simundump kreac /kinetics/chain/kinetics[25]/PKC/PKC-DAG-memb*/diff 0 0.101 \ 0.001 "" white black 103.17 8.5078 0 simundump kpool /kinetics/chain/kinetics[25]/PKC/PKC-Ca-DAG 0 -1e-12 \ 0.00089226 0.00089226 67.273 67.273 0 0 75396 0 /kinetics/dendgeom white \ blue 104.23 1.8026 0 simundump kreac /kinetics/chain/kinetics[25]/PKC/PKC-Ca-DAG/diff 0 0.101 \ 0.001 "" white black 105.23 4.8026 0 simundump kreac /kinetics/chain/kinetics[25]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 100.99 -1.9902 0 simundump kpool /kinetics/chain/kinetics[25]/PKC/PKC-DAG 0 -1e-12 0.060193 \ 0.060193 4538.3 4538.3 0 0 75396 0 /kinetics/dendgeom white blue 103 \ -1.0857 0 simundump kreac /kinetics/chain/kinetics[25]/PKC/PKC-DAG/diff 0 0.101 0.001 \ "" white black 104 1.9143 0 simundump kpool /kinetics/chain/kinetics[25]/PKC/PKC-cytosolic 0 -1e-12 \ 0.8223 0.8223 61998 61998 0 0 75396 0 /kinetics/dendgeom white blue 97.868 \ 0.59711 0 simundump kreac /kinetics/chain/kinetics[25]/PKC/PKC-cytosolic/diff 0 0.101 \ 0.001 "" white black 98.868 3.5971 0 simundump kpool /kinetics/chain/kinetics[25]/PKC/PKM-zeta 0 -1e-12 0.01007 \ 0.01007 759.21 759.21 0 0 75396 0 /kinetics/dendgeom cyan blue 101 11 0 simundump kreac /kinetics/chain/kinetics[25]/PKC/PKM-zeta/diff 0 0.101 0.001 \ "" white black 102 14 0 simundump kpool /kinetics/chain/kinetics[25]/DAG 1 -1e-12 12.2 12.2 \ 9.1983e+05 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 108 -3 0 simundump kpool /kinetics/chain/kinetics[25]/PKC-active 1 -1e-12 0.047627 \ 0.047626 3590.8 3590.9 0 0 75396 2 /kinetics/dendgeom red black 104 9 0 simundump kenz /kinetics/chain/kinetics[25]/PKC-active/PKC-act-raf 1 \ 0.0011493 0.0011493 86.652 86.652 75396 1.3263e-05 16 4 0 0 "" red yellow \ "" 110 10 0 simundump kenz /kinetics/chain/kinetics[25]/PKC-active/PKC-inact-GAP 1 53.939 \ 53.939 6.778 6.778 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 108 13 0 simundump kenz /kinetics/chain/kinetics[25]/PKC-active/PKC-act-GEF 1 726.99 \ 726.99 91.354 91.354 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 113 20 0 simundump kpool /kinetics/chain/kinetics[25]/MAPK* 1 -1e-12 7.8539e-05 \ 7.8539e-05 5.9215 5.9215 0 0 75396 0 /kinetics/dendgeom orange yellow 117 1 \ 0 simundump kenz /kinetics/chain/kinetics[25]/MAPK*/MAPK*-feedback 1 3.6779e-08 \ 3.6779e-08 0.002773 0.002773 75396 2.5864e-05 40 10 0 0 "" red orange "" \ 114 10 0 simundump kreac /kinetics/chain/kinetics[25]/MAPK*/diff 0 0.101 0.001 "" \ white black 118 4 0 simundump group /kinetics/chain/kinetics[25]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 119 11 0 simundump kpool /kinetics/chain/kinetics[25]/MAPK/craf-1 0 0 0.48263 0.48263 \ 36388 36388 0 0 75396 0 /kinetics/dendgeom pink brown 110 8 0 simundump kreac /kinetics/chain/kinetics[25]/MAPK/craf-1/diff 0 0.101 0.001 \ "" white black 111 11 0 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simundump kenz /kinetics/chain/kinetics[25]/PPhosphatase2A/craf-deph 1 \ 0.00076621 0.00076621 57.769 57.769 75396 2.5414e-05 24 6 0 0 "" red \ hotpink "" 112 10 0 simundump kenz /kinetics/chain/kinetics[25]/PPhosphatase2A/MAPKK-deph 1 \ 5.2573e-07 5.2573e-07 0.039638 0.039638 75396 2.5414e-05 24 6 0 0 "" red \ hotpink "" 115 7 0 simundump kenz /kinetics/chain/kinetics[25]/PPhosphatase2A/MAPKK-deph-ser 1 \ 0.00012882 0.00012882 9.7128 9.7128 75396 2.5414e-05 24 6 0 0 "" red \ hotpink "" 112 7 0 simundump kenz /kinetics/chain/kinetics[25]/PPhosphatase2A/craf**-deph 1 \ 0.036779 0.036779 0.0046216 0.0046216 0.12566 2.5414e-05 24 6 0 0 "" red \ hotpink "" 116 10 0 simundump kreac /kinetics/chain/kinetics[25]/PPhosphatase2A/diff 0 0.101 \ 0.001 "" white black 114 12 0 simundump group /kinetics/chain/kinetics[25]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 118.51 16.351 0 simundump kreac /kinetics/chain/kinetics[25]/Ras/dephosph-GEF 1 1 0 "" white \ blue 113.07 17.881 0 simundump kpool /kinetics/chain/kinetics[25]/Ras/inact-GEF 1 -1e-12 0.084803 \ 0.084803 6393.8 6393.8 0 0 75396 0 /kinetics/dendgeom hotpink blue 116.45 \ 18.352 0 simundump kenz /kinetics/chain/kinetics[25]/Ras/inact-GEF/basal_GEF_activity 0 \ 0.0040648 0.0040648 306.47 306.47 75396 1.313e-07 0.08 0.02 0 0 "" red \ hotpink "" 116 17 0 simundump kreac /kinetics/chain/kinetics[25]/Ras/inact-GEF/diff 0 0.101 0.001 \ "" white black 117.45 21.352 0 simundump kpool /kinetics/chain/kinetics[25]/Ras/GEF* 1 -1e-12 0.0048465 \ 0.0048465 365.41 365.41 0 0 75396 0 /kinetics/dendgeom hotpink blue 110.45 \ 17.246 0 simundump kenz /kinetics/chain/kinetics[25]/Ras/GEF*/GEF*-act-ras 1 0.0046465 \ 0.0046465 350.33 350.33 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" \ 111.09 16.086 0 simundump kreac /kinetics/chain/kinetics[25]/Ras/GEF*/diff 0 0.101 0.001 "" \ white black 111.45 20.246 0 simundump kpool /kinetics/chain/kinetics[25]/Ras/GTP-Ras 1 0 0.0034512 \ 0.0034512 260.21 260.21 0 0 75396 0 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/kinetics/dendgeom red blue 110.65 \ 12.338 0 simundump kenz /kinetics/chain/kinetics[25]/Ras/GAP/GAP-inact-ras 1 \ 2.1491e-05 2.1491e-05 1.6203 1.6203 75396 0.00065634 40 10 0 0 "" red red \ "" 113.01 12.403 0 simundump kreac /kinetics/chain/kinetics[25]/Ras/GAP/diff 0 0.101 0.001 "" \ white black 111.65 15.338 0 simundump kreac /kinetics/chain/kinetics[25]/Ras/CaM-bind-GEF 1 0.0026526 1 \ "" white blue 106.49 21.679 0 simundump kpool /kinetics/chain/kinetics[25]/Ras/CaM-GEF 1 -1e-12 0.00021398 \ 0.00021398 16.133 16.133 0 0 75396 0 /kinetics/dendgeom pink blue 109.35 \ 19.58 0 simundump kenz /kinetics/chain/kinetics[25]/Ras/CaM-GEF/CaM-GEF-act-ras 1 \ 0.00020513 0.00020513 15.466 15.466 75396 2.6261e-05 0.8 0.2 0 0 "" red \ pink "" 109.02 18.657 0 simundump kreac /kinetics/chain/kinetics[25]/Ras/CaM-GEF/diff 0 0.101 0.001 \ "" white black 110.35 22.58 0 simundump group /kinetics/chain/kinetics[25]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 94 21 0 simundump kpool /kinetics/chain/kinetics[25]/CaM/CaM 1 -1e-12 18.403 18.403 \ 1.3875e+06 1.3875e+06 0 0 75396 0 /kinetics/dendgeom pink blue 91 30 0 simundump kreac /kinetics/chain/kinetics[25]/CaM/CaM/diff 0 0.101 0.001 "" \ white black 92 33 0 simundump kreac /kinetics/chain/kinetics[25]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 93.6 23.26 0 simundump kpool /kinetics/chain/kinetics[25]/CaM/CaM-Ca3 1 -1e-12 0.0033914 \ 0.0033914 255.7 255.7 0 0 75396 0 /kinetics/dendgeom hotpink blue 97.489 \ 24.397 0 simundump kreac /kinetics/chain/kinetics[25]/CaM/CaM-Ca3/diff 0 0.101 0.001 \ "" white black 98.489 27.397 0 simundump kpool /kinetics/chain/kinetics[25]/CaM/CaM-Ca4 1 -1e-12 1.2616e-05 \ 1.2616e-05 0.95122 0.95122 0 0 75396 0 /kinetics/dendgeom blue blue 102 24 \ 0 simundump kreac /kinetics/chain/kinetics[25]/CaM/CaM-Ca4/diff 0 0.101 0.001 \ "" white black 103 27 0 simundump kreac /kinetics/chain/kinetics[25]/CaM/CaM-bind-Ca 1 0.00011254 \ 8.4853 "" white blue 94 30 0 simundump kpool 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15070 0 0 75396 0 /kinetics/dendgeom 6 25 97 12 0 simundump kreac /kinetics/chain/kinetics[27]/PKM/PKM_activator/diff 0 0.101 \ 0.001 "" white black 98 15 0 simundump kreac /kinetics/chain/kinetics[27]/PKM/turn_off_activator 0 0.001 0 \ "" white 25 95 9 0 simundump kreac /kinetics/chain/kinetics[27]/PKM/trigger_PKM 0 0.00013263 1 \ "" white 25 95 16 0 simundump kpool /kinetics/chain/kinetics[27]/Ca_input 0 0 0.08 0.08 6031.7 \ 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 94 30 0 simundump kreac /kinetics/chain/kinetics[27]/Ca_diff 0 5 5 "" white black 94 \ 26 0 simundump group /kinetics/chain/kinetics[28] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 116 0 0 simundump group /kinetics/chain/kinetics[28]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 112.95 8.2163 0 simundump kpool /kinetics/chain/kinetics[28]/PKC/PKC-Ca 0 -1e-12 0.078942 \ 0.078942 5951.9 5951.9 0 0 75396 0 /kinetics/dendgeom red black 111.92 \ 1.5108 0 simundump kreac 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16 4 0 0 "" red yellow "" 125 20 0 simundump kpool /kinetics/chain/kinetics[28]/MAPK* 1 -1e-12 7.8539e-05 \ 7.8539e-05 5.9215 5.9215 0 0 75396 0 /kinetics/dendgeom orange yellow 129 1 \ 0 simundump kenz /kinetics/chain/kinetics[28]/MAPK*/MAPK*-feedback 1 3.6779e-08 \ 3.6779e-08 0.002773 0.002773 75396 2.5864e-05 40 10 0 0 "" red orange "" \ 126 10 0 simundump kreac /kinetics/chain/kinetics[28]/MAPK*/diff 0 0.101 0.001 "" \ white black 130 4 0 simundump group /kinetics/chain/kinetics[28]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 131 11 0 simundump kpool /kinetics/chain/kinetics[28]/MAPK/craf-1 0 0 0.48263 0.48263 \ 36388 36388 0 0 75396 0 /kinetics/dendgeom pink brown 122 8 0 simundump kreac /kinetics/chain/kinetics[28]/MAPK/craf-1/diff 0 0.101 0.001 \ "" white black 123 11 0 simundump kpool /kinetics/chain/kinetics[28]/MAPK/craf-1* 0 0 0.012007 \ 0.012007 905.28 905.28 0 0 75396 0 /kinetics/dendgeom pink brown 125 8 0 simundump kreac 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"" white black 122 8 0 simundump kpool /kinetics/chain/kinetics[28]/MKP-1 1 -1e-12 0.019951 0.019951 \ 1504.2 1504.2 0 0 75396 0 /kinetics/dendgeom hotpink black 121 2 0 simundump kenz /kinetics/chain/kinetics[28]/MKP-1/MKP1-tyr-deph 1 4.781e-05 \ 4.781e-05 3.6047 3.6047 75396 3.7895e-05 16 4 0 0 "" red hotpink "" 122 3 0 simundump kenz /kinetics/chain/kinetics[28]/MKP-1/MKP1-thr-deph 1 2.2386e-07 \ 2.2386e-07 0.016878 0.016878 75396 3.7895e-05 16 4 0 0 "" red hotpink "" \ 127 3 0 simundump kreac /kinetics/chain/kinetics[28]/MKP-1/diff 0 0.101 0.001 "" \ white black 122 5 0 simundump kreac /kinetics/chain/kinetics[28]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 119 9 0 simundump kpool /kinetics/chain/kinetics[28]/PPhosphatase2A 1 -1e-12 0.9991 \ 0.9991 75328 75328 0 0 75396 0 /kinetics/dendgeom hotpink yellow 125 9 0 simundump kenz /kinetics/chain/kinetics[28]/PPhosphatase2A/craf-deph 1 \ 0.00076621 0.00076621 57.769 57.769 75396 2.5414e-05 24 6 0 0 "" red \ hotpink "" 124 10 0 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40 10 0 0 "" red red \ "" 125.01 12.403 0 simundump kreac /kinetics/chain/kinetics[28]/Ras/GAP/diff 0 0.101 0.001 "" \ white black 123.65 15.338 0 simundump kreac /kinetics/chain/kinetics[28]/Ras/CaM-bind-GEF 1 0.0026526 1 \ "" white blue 118.49 21.679 0 simundump kpool /kinetics/chain/kinetics[28]/Ras/CaM-GEF 1 -1e-12 0.00021398 \ 0.00021398 16.133 16.133 0 0 75396 0 /kinetics/dendgeom pink blue 121.35 \ 19.58 0 simundump kenz /kinetics/chain/kinetics[28]/Ras/CaM-GEF/CaM-GEF-act-ras 1 \ 0.00020513 0.00020513 15.466 15.466 75396 2.6261e-05 0.8 0.2 0 0 "" red \ pink "" 121.02 18.657 0 simundump kreac /kinetics/chain/kinetics[28]/Ras/CaM-GEF/diff 0 0.101 0.001 \ "" white black 122.35 22.58 0 simundump group /kinetics/chain/kinetics[28]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 106 21 0 simundump kpool /kinetics/chain/kinetics[28]/CaM/CaM 1 -1e-12 18.403 18.403 \ 1.3875e+06 1.3875e+06 0 0 75396 0 /kinetics/dendgeom pink blue 103 30 0 simundump kreac 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16 0 simundump kpool /kinetics/chain/kinetics[28]/Ca_input 0 0 0.08 0.08 6031.7 \ 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 98 30 0 simundump kreac /kinetics/chain/kinetics[28]/Ca_diff 0 5 5 "" white black 98 \ 26 0 simundump group /kinetics/chain/kinetics[29] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 120 0 0 simundump group /kinetics/chain/kinetics[29]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 116.95 8.2163 0 simundump kpool /kinetics/chain/kinetics[29]/PKC/PKC-Ca 0 -1e-12 0.078942 \ 0.078942 5951.9 5951.9 0 0 75396 0 /kinetics/dendgeom red black 115.92 \ 1.5108 0 simundump kreac /kinetics/chain/kinetics[29]/PKC/PKC-Ca/diff 0 0.101 0.001 "" \ white black 116.92 4.5108 0 simundump kreac /kinetics/chain/kinetics[29]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 115.92 -0.12295 0 simundump kreac /kinetics/chain/kinetics[29]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 117.94 0.69395 0 simundump kreac 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\ 0.001 "" white black 121.23 4.8026 0 simundump kreac /kinetics/chain/kinetics[29]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 116.99 -1.9902 0 simundump kpool /kinetics/chain/kinetics[29]/PKC/PKC-DAG 0 -1e-12 0.060193 \ 0.060193 4538.3 4538.3 0 0 75396 0 /kinetics/dendgeom white blue 119 \ -1.0857 0 simundump kreac /kinetics/chain/kinetics[29]/PKC/PKC-DAG/diff 0 0.101 0.001 \ "" white black 120 1.9143 0 simundump kpool /kinetics/chain/kinetics[29]/PKC/PKC-cytosolic 0 -1e-12 \ 0.8223 0.8223 61998 61998 0 0 75396 0 /kinetics/dendgeom white blue 113.87 \ 0.59711 0 simundump kreac /kinetics/chain/kinetics[29]/PKC/PKC-cytosolic/diff 0 0.101 \ 0.001 "" white black 114.87 3.5971 0 simundump kpool /kinetics/chain/kinetics[29]/PKC/PKM-zeta 0 -1e-12 0.01007 \ 0.01007 759.21 759.21 0 0 75396 0 /kinetics/dendgeom cyan blue 117 11 0 simundump kreac /kinetics/chain/kinetics[29]/PKC/PKM-zeta/diff 0 0.101 0.001 \ "" white black 118 14 0 simundump kpool /kinetics/chain/kinetics[29]/DAG 1 -1e-12 12.2 12.2 \ 9.1983e+05 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 124 -3 0 simundump kpool /kinetics/chain/kinetics[29]/PKC-active 1 -1e-12 0.047627 \ 0.047626 3590.8 3590.9 0 0 75396 2 /kinetics/dendgeom red black 120 9 0 simundump kenz /kinetics/chain/kinetics[29]/PKC-active/PKC-act-raf 1 \ 0.0011493 0.0011493 86.652 86.652 75396 1.3263e-05 16 4 0 0 "" red yellow \ "" 126 10 0 simundump kenz /kinetics/chain/kinetics[29]/PKC-active/PKC-inact-GAP 1 53.939 \ 53.939 6.778 6.778 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 124 13 0 simundump kenz /kinetics/chain/kinetics[29]/PKC-active/PKC-act-GEF 1 726.99 \ 726.99 91.354 91.354 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 129 20 0 simundump kpool /kinetics/chain/kinetics[29]/MAPK* 1 -1e-12 7.8539e-05 \ 7.8539e-05 5.9215 5.9215 0 0 75396 0 /kinetics/dendgeom orange yellow 133 1 \ 0 simundump kenz /kinetics/chain/kinetics[29]/MAPK*/MAPK*-feedback 1 3.6779e-08 \ 3.6779e-08 0.002773 0.002773 75396 2.5864e-05 40 10 0 0 "" red orange 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0.101 \ 0.001 "" white black 110 15 0 simundump kreac /kinetics/chain/kinetics[30]/PKM/turn_off_activator 0 0.001 0 \ "" white 25 107 9 0 simundump kreac /kinetics/chain/kinetics[30]/PKM/trigger_PKM 0 0.00013263 1 \ "" white 25 107 16 0 simundump kpool /kinetics/chain/kinetics[30]/Ca_input 0 0 0.08 0.08 6031.7 \ 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 106 30 0 simundump kreac /kinetics/chain/kinetics[30]/Ca_diff 0 5 5 "" white black 106 \ 26 0 simundump group /kinetics/chain/kinetics[31] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 128 0 0 simundump group /kinetics/chain/kinetics[31]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 124.95 8.2163 0 simundump kpool /kinetics/chain/kinetics[31]/PKC/PKC-Ca 0 -1e-12 0.078942 \ 0.078942 5951.9 5951.9 0 0 75396 0 /kinetics/dendgeom red black 123.92 \ 1.5108 0 simundump kreac /kinetics/chain/kinetics[31]/PKC/PKC-Ca/diff 0 0.101 0.001 "" \ white black 124.92 4.5108 0 simundump kreac /kinetics/chain/kinetics[31]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 123.92 -0.12295 0 simundump kreac /kinetics/chain/kinetics[31]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 125.94 0.69395 0 simundump kreac /kinetics/chain/kinetics[31]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 124.2 4.2533 0 simundump kreac /kinetics/chain/kinetics[31]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 125.38 2.7362 0 simundump kpool /kinetics/chain/kinetics[31]/PKC/PKC-Ca-memb* 0 -1e-12 \ 0.028634 0.028634 2158.9 2158.9 0 0 75396 0 /kinetics/dendgeom pink blue \ 125.22 6.529 0 simundump kreac /kinetics/chain/kinetics[31]/PKC/PKC-Ca-memb*/diff 0 0.101 \ 0.001 "" white black 126.22 9.529 0 simundump kpool /kinetics/chain/kinetics[31]/PKC/PKC-DAG-memb* 0 -1e-12 \ 0.0089225 0.0089225 672.72 672.72 0 0 75396 0 /kinetics/dendgeom yellow \ blue 126.17 5.5078 0 simundump kreac /kinetics/chain/kinetics[31]/PKC/PKC-DAG-memb*/diff 0 0.101 \ 0.001 "" white black 127.17 8.5078 0 simundump kpool /kinetics/chain/kinetics[31]/PKC/PKC-Ca-DAG 0 -1e-12 \ 0.00089226 0.00089226 67.273 67.273 0 0 75396 0 /kinetics/dendgeom white \ blue 128.23 1.8026 0 simundump kreac /kinetics/chain/kinetics[31]/PKC/PKC-Ca-DAG/diff 0 0.101 \ 0.001 "" white black 129.23 4.8026 0 simundump kreac /kinetics/chain/kinetics[31]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 124.99 -1.9902 0 simundump kpool /kinetics/chain/kinetics[31]/PKC/PKC-DAG 0 -1e-12 0.060193 \ 0.060193 4538.3 4538.3 0 0 75396 0 /kinetics/dendgeom white blue 127 \ -1.0857 0 simundump kreac /kinetics/chain/kinetics[31]/PKC/PKC-DAG/diff 0 0.101 0.001 \ "" white black 128 1.9143 0 simundump kpool /kinetics/chain/kinetics[31]/PKC/PKC-cytosolic 0 -1e-12 \ 0.8223 0.8223 61998 61998 0 0 75396 0 /kinetics/dendgeom white blue 121.87 \ 0.59711 0 simundump kreac /kinetics/chain/kinetics[31]/PKC/PKC-cytosolic/diff 0 0.101 \ 0.001 "" white black 122.87 3.5971 0 simundump kpool /kinetics/chain/kinetics[31]/PKC/PKM-zeta 0 -1e-12 0.01007 \ 0.01007 759.21 759.21 0 0 75396 0 /kinetics/dendgeom cyan blue 125 11 0 simundump kreac /kinetics/chain/kinetics[31]/PKC/PKM-zeta/diff 0 0.101 0.001 \ "" white black 126 14 0 simundump kpool /kinetics/chain/kinetics[31]/DAG 1 -1e-12 12.2 12.2 \ 9.1983e+05 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 132 -3 0 simundump kpool /kinetics/chain/kinetics[31]/PKC-active 1 -1e-12 0.047627 \ 0.047626 3590.8 3590.9 0 0 75396 2 /kinetics/dendgeom red black 128 9 0 simundump kenz /kinetics/chain/kinetics[31]/PKC-active/PKC-act-raf 1 \ 0.0011493 0.0011493 86.652 86.652 75396 1.3263e-05 16 4 0 0 "" red yellow \ "" 134 10 0 simundump kenz /kinetics/chain/kinetics[31]/PKC-active/PKC-inact-GAP 1 53.939 \ 53.939 6.778 6.778 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 132 13 0 simundump kenz /kinetics/chain/kinetics[31]/PKC-active/PKC-act-GEF 1 726.99 \ 726.99 91.354 91.354 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 137 20 0 simundump kpool /kinetics/chain/kinetics[31]/MAPK* 1 -1e-12 7.8539e-05 \ 7.8539e-05 5.9215 5.9215 0 0 75396 0 /kinetics/dendgeom orange yellow 141 1 \ 0 simundump kenz /kinetics/chain/kinetics[31]/MAPK*/MAPK*-feedback 1 3.6779e-08 \ 3.6779e-08 0.002773 0.002773 75396 2.5864e-05 40 10 0 0 "" red orange "" \ 138 10 0 simundump kreac /kinetics/chain/kinetics[31]/MAPK*/diff 0 0.101 0.001 "" \ white black 142 4 0 simundump group /kinetics/chain/kinetics[31]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 143 11 0 simundump kpool /kinetics/chain/kinetics[31]/MAPK/craf-1 0 0 0.48263 0.48263 \ 36388 36388 0 0 75396 0 /kinetics/dendgeom pink brown 134 8 0 simundump kreac /kinetics/chain/kinetics[31]/MAPK/craf-1/diff 0 0.101 0.001 \ "" white black 135 11 0 simundump kpool /kinetics/chain/kinetics[31]/MAPK/craf-1* 0 0 0.012007 \ 0.012007 905.28 905.28 0 0 75396 0 /kinetics/dendgeom pink brown 137 8 0 simundump kreac /kinetics/chain/kinetics[31]/MAPK/craf-1*/diff 0 0.101 0.001 \ "" white black 138 11 0 simundump kpool /kinetics/chain/kinetics[31]/MAPK/MAPKK 0 0 0.4946 0.4946 \ 37291 37291 0 0 75396 0 /kinetics/dendgeom pink brown 134 4 0 simundump kreac /kinetics/chain/kinetics[31]/MAPK/MAPKK/diff 0 0.101 0.001 "" \ white black 135 7 0 simundump kpool /kinetics/chain/kinetics[31]/MAPK/MAPK 0 -1e-12 3.5824 3.5824 \ 2.701e+05 2.701e+05 0 0 75396 0 /kinetics/dendgeom pink brown 134 1 0 simundump kreac /kinetics/chain/kinetics[31]/MAPK/MAPK/diff 0 0.101 0.001 "" \ white black 135 4 0 simundump kpool /kinetics/chain/kinetics[31]/MAPK/craf-1** 1 0 9.6059e-07 \ 9.6059e-07 0.072425 0.072425 0 0 75396 0 /kinetics/dendgeom hotpink brown \ 140 8 0 simundump kreac /kinetics/chain/kinetics[31]/MAPK/craf-1**/diff 0 0.101 0.001 \ "" white black 141 11 0 simundump kpool /kinetics/chain/kinetics[31]/MAPK/MAPK-tyr 1 -1e-12 0.016774 \ 0.016774 1264.7 1264.7 0 0 75396 0 /kinetics/dendgeom orange brown 137 1 0 simundump kreac /kinetics/chain/kinetics[31]/MAPK/MAPK-tyr/diff 0 0.101 0.001 \ "" white black 138 4 0 simundump kpool /kinetics/chain/kinetics[31]/MAPK/MAPKK* 0 0 8.2386e-06 \ 8.2386e-06 0.62116 0.62116 0 0 75396 0 /kinetics/dendgeom pink brown 141 4 \ 0 simundump kenz /kinetics/chain/kinetics[31]/MAPK/MAPKK*/MAPKKtyr 0 0.00063751 \ 0.00063751 48.066 48.066 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 136 3 \ 0 simundump kenz /kinetics/chain/kinetics[31]/MAPK/MAPKK*/MAPKKthr 1 2.985e-06 \ 2.985e-06 0.22506 0.22506 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 141 3 \ 0 simundump kreac /kinetics/chain/kinetics[31]/MAPK/MAPKK*/diff 0 0.101 0.001 \ "" white black 142 7 0 simundump kpool /kinetics/chain/kinetics[31]/MAPK/MAPKK-ser 1 0 0.0020188 \ 0.0020188 152.21 152.21 0 0 75396 0 /kinetics/dendgeom pink brown 137 4 0 simundump kreac /kinetics/chain/kinetics[31]/MAPK/MAPKK-ser/diff 0 0.101 \ 0.001 "" white black 138 7 0 simundump kpool /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 133 6 0 simundump kenz /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 136 6 0 simundump kenz /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 139 6 0 simundump kreac /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras/diff 0 0.101 \ 0.001 "" white black 134 9 0 simundump kpool /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras 1 0 0.00082874 \ 0.00082874 62.484 62.484 0 0 75396 0 /kinetics/dendgeom red brown 133 5 0 simundump kenz /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 1545.9 1545.9 194.26 194.26 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" \ 136 5 0 simundump kenz /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 6.3096 6.3096 0.79287 0.79287 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" \ 139 5 0 simundump kreac /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras/diff 0 0.101 \ 0.001 "" white black 134 8 0 simundump kpool /kinetics/chain/kinetics[31]/MKP-1 1 -1e-12 0.019951 0.019951 \ 1504.2 1504.2 0 0 75396 0 /kinetics/dendgeom hotpink black 133 2 0 simundump kenz /kinetics/chain/kinetics[31]/MKP-1/MKP1-tyr-deph 1 4.781e-05 \ 4.781e-05 3.6047 3.6047 75396 3.7895e-05 16 4 0 0 "" red hotpink "" 134 3 0 simundump kenz /kinetics/chain/kinetics[31]/MKP-1/MKP1-thr-deph 1 2.2386e-07 \ 2.2386e-07 0.016878 0.016878 75396 3.7895e-05 16 4 0 0 "" red hotpink "" \ 139 3 0 simundump kreac /kinetics/chain/kinetics[31]/MKP-1/diff 0 0.101 0.001 "" \ white black 134 5 0 simundump kreac /kinetics/chain/kinetics[31]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 131 9 0 simundump kpool /kinetics/chain/kinetics[31]/PPhosphatase2A 1 -1e-12 0.9991 \ 0.9991 75328 75328 0 0 75396 0 /kinetics/dendgeom hotpink yellow 137 9 0 simundump kenz /kinetics/chain/kinetics[31]/PPhosphatase2A/craf-deph 1 \ 0.00076621 0.00076621 57.769 57.769 75396 2.5414e-05 24 6 0 0 "" red \ hotpink "" 136 10 0 simundump kenz 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/kinetics/chain/kinetics[31]/Ras/GDP-Ras 1 0 0.48419 0.48419 \ 36506 36506 0 0 75396 0 /kinetics/dendgeom pink blue 134.13 14.165 0 simundump kreac /kinetics/chain/kinetics[31]/Ras/GDP-Ras/diff 0 0.101 0.001 \ "" white black 135.13 17.165 0 simundump kreac /kinetics/chain/kinetics[31]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 137.1 13.5 0 simundump kreac /kinetics/chain/kinetics[31]/Ras/dephosph-GAP 1 0.1 0 "" \ white blue 132.02 15.524 0 simundump kpool /kinetics/chain/kinetics[31]/Ras/GAP* 1 -1e-12 0.0035959 \ 0.0035959 271.12 271.12 0 0 75396 0 /kinetics/dendgeom red blue 129.35 \ 14.349 0 simundump kreac /kinetics/chain/kinetics[31]/Ras/GAP*/diff 0 0.101 0.001 "" \ white black 130.35 17.349 0 simundump kpool /kinetics/chain/kinetics[31]/Ras/GAP 1 -1e-12 0.0062918 \ 0.0062918 474.38 474.38 0 0 75396 0 /kinetics/dendgeom red blue 134.65 \ 12.338 0 simundump kenz /kinetics/chain/kinetics[31]/Ras/GAP/GAP-inact-ras 1 \ 2.1491e-05 2.1491e-05 1.6203 1.6203 75396 0.00065634 40 10 0 0 "" red red \ "" 137.01 12.403 0 simundump kreac /kinetics/chain/kinetics[31]/Ras/GAP/diff 0 0.101 0.001 "" \ white black 135.65 15.338 0 simundump kreac /kinetics/chain/kinetics[31]/Ras/CaM-bind-GEF 1 0.0026526 1 \ "" white blue 130.49 21.679 0 simundump kpool /kinetics/chain/kinetics[31]/Ras/CaM-GEF 1 -1e-12 0.00021398 \ 0.00021398 16.133 16.133 0 0 75396 0 /kinetics/dendgeom pink blue 133.35 \ 19.58 0 simundump kenz /kinetics/chain/kinetics[31]/Ras/CaM-GEF/CaM-GEF-act-ras 1 \ 0.00020513 0.00020513 15.466 15.466 75396 2.6261e-05 0.8 0.2 0 0 "" red \ pink "" 133.02 18.657 0 simundump kreac /kinetics/chain/kinetics[31]/Ras/CaM-GEF/diff 0 0.101 0.001 \ "" white black 134.35 22.58 0 simundump group /kinetics/chain/kinetics[31]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 118 21 0 simundump kpool /kinetics/chain/kinetics[31]/CaM/CaM 1 -1e-12 18.403 18.403 \ 1.3875e+06 1.3875e+06 0 0 75396 0 /kinetics/dendgeom pink blue 115 30 0 simundump kreac /kinetics/chain/kinetics[31]/CaM/CaM/diff 0 0.101 0.001 "" \ white black 116 33 0 simundump kreac /kinetics/chain/kinetics[31]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 117.6 23.26 0 simundump kpool /kinetics/chain/kinetics[31]/CaM/CaM-Ca3 1 -1e-12 0.0033914 \ 0.0033914 255.7 255.7 0 0 75396 0 /kinetics/dendgeom hotpink blue 121.49 \ 24.397 0 simundump kreac /kinetics/chain/kinetics[31]/CaM/CaM-Ca3/diff 0 0.101 0.001 \ "" white black 122.49 27.397 0 simundump kpool /kinetics/chain/kinetics[31]/CaM/CaM-Ca4 1 -1e-12 1.2616e-05 \ 1.2616e-05 0.95122 0.95122 0 0 75396 0 /kinetics/dendgeom blue blue 126 24 \ 0 simundump kreac /kinetics/chain/kinetics[31]/CaM/CaM-Ca4/diff 0 0.101 0.001 \ "" white black 127 27 0 simundump kreac /kinetics/chain/kinetics[31]/CaM/CaM-bind-Ca 1 0.00011254 \ 8.4853 "" white blue 118 30 0 simundump kpool /kinetics/chain/kinetics[31]/CaM/CaM-Ca2 1 -1e-12 0.11776 \ 0.11776 8878.5 8878.5 0 0 75396 0 /kinetics/dendgeom pink blue 123 27.258 0 simundump kreac /kinetics/chain/kinetics[31]/CaM/CaM-Ca2/diff 0 0.101 0.001 \ "" white black 124 30.258 0 simundump kreac /kinetics/chain/kinetics[31]/CaM/CaM-Ca2-bind-Ca 1 4.7748e-05 \ 10 "" white blue 119.16 26.225 0 simundump kreac /kinetics/chain/kinetics[31]/CaM/CaM-Ca-bind-Ca 1 0.00011254 \ 8.4853 "" white blue 124 30 0 simundump kpool /kinetics/chain/kinetics[31]/CaM/CaM-Ca 1 -1e-12 1.472 1.472 \ 1.1098e+05 1.1098e+05 0 0 75396 0 /kinetics/dendgeom pink blue 121 31 0 simundump kreac /kinetics/chain/kinetics[31]/CaM/CaM-Ca/diff 0 0.101 0.001 "" \ white black 122 34 0 simundump kpool /kinetics/chain/kinetics[31]/Ca 1 -1e-12 0.08 0.08 6031.7 \ 6031.7 0 0 75396 0 /kinetics/dendgeom red black 110 23 0 simundump kreac /kinetics/chain/kinetics[31]/Ca/diff 0 0.101 0.001 "" white \ black 111 26 0 simundump kreac /kinetics/chain/kinetics[31]/Ras-act-unphosph-raf 0 0 0 "" \ white black 132 8 0 simundump group /kinetics/chain/kinetics[31]/PKM 0 25 black x 0 0 "" PKM \ defaultfile.g 0 5dc016e940e88c1cc7928f4e096ff523 0 121 19 0 simundump kpool /kinetics/chain/kinetics[31]/PKM/Ca_detector 0 -1e-12 0.99987 \ 0.99987 75386 75386 0 0 75396 0 /kinetics/dendgeom 7 25 117 17 0 simundump kreac /kinetics/chain/kinetics[31]/PKM/Ca_detector/diff 0 0.101 \ 0.001 "" white black 118 20 0 simundump kpool /kinetics/chain/kinetics[31]/PKM/PKM_synthesis 0 -1e-12 \ 0.0010085 0.0010085 76.04 76.04 0 0 75396 0 /kinetics/dendgeom 8 25 117 9 0 simundump kenz /kinetics/chain/kinetics[31]/PKM/PKM_synthesis/kenz 0 \ 0.00010086 0.00010086 7.6041 7.6041 75396 3.3159e-07 0.2 0.05 0 0 "" red 8 \ "" 118 10 0 simundump kreac /kinetics/chain/kinetics[31]/PKM/PKM_synthesis/diff 0 0.101 \ 0.001 "" white black 118 12 0 simundump kpool /kinetics/chain/kinetics[31]/PKM/AA_pool 0 -1e-12 1 1 75396 \ 75396 0 0 75396 4 /kinetics/dendgeom 9 25 121 12 0 simundump kreac /kinetics/chain/kinetics[31]/PKM/PKM_degradation 0 0.0005 0 \ "" white 25 120 7 0 simundump kpool 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111 16 0 simundump kpool /kinetics/chain/kinetics[31]/Ca_input 0 0 0.08 0.08 6031.7 \ 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 110 30 0 simundump kreac /kinetics/chain/kinetics[31]/Ca_diff 0 5 5 "" white black 110 \ 26 0 simundump group /kinetics/chain/kinetics[32] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 132 0 0 simundump group /kinetics/chain/kinetics[32]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 128.95 8.2163 0 simundump kpool /kinetics/chain/kinetics[32]/PKC/PKC-Ca 0 -1e-12 0.078942 \ 0.078942 5951.9 5951.9 0 0 75396 0 /kinetics/dendgeom red black 127.92 \ 1.5108 0 simundump kreac /kinetics/chain/kinetics[32]/PKC/PKC-Ca/diff 0 0.101 0.001 "" \ white black 128.92 4.5108 0 simundump kreac /kinetics/chain/kinetics[32]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 127.92 -0.12295 0 simundump kreac /kinetics/chain/kinetics[32]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 129.94 0.69395 0 simundump kreac 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\ 0.001 "" white black 133.23 4.8026 0 simundump kreac /kinetics/chain/kinetics[32]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 128.99 -1.9902 0 simundump kpool /kinetics/chain/kinetics[32]/PKC/PKC-DAG 0 -1e-12 0.060193 \ 0.060193 4538.3 4538.3 0 0 75396 0 /kinetics/dendgeom white blue 131 \ -1.0857 0 simundump kreac /kinetics/chain/kinetics[32]/PKC/PKC-DAG/diff 0 0.101 0.001 \ "" white black 132 1.9143 0 simundump kpool /kinetics/chain/kinetics[32]/PKC/PKC-cytosolic 0 -1e-12 \ 0.8223 0.8223 61998 61998 0 0 75396 0 /kinetics/dendgeom white blue 125.87 \ 0.59711 0 simundump kreac /kinetics/chain/kinetics[32]/PKC/PKC-cytosolic/diff 0 0.101 \ 0.001 "" white black 126.87 3.5971 0 simundump kpool /kinetics/chain/kinetics[32]/PKC/PKM-zeta 0 -1e-12 0.01007 \ 0.01007 759.21 759.21 0 0 75396 0 /kinetics/dendgeom cyan blue 129 11 0 simundump kreac /kinetics/chain/kinetics[32]/PKC/PKM-zeta/diff 0 0.101 0.001 \ "" white black 130 14 0 simundump kpool /kinetics/chain/kinetics[32]/DAG 1 -1e-12 12.2 12.2 \ 9.1983e+05 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 136 -3 0 simundump kpool /kinetics/chain/kinetics[32]/PKC-active 1 -1e-12 0.047627 \ 0.047626 3590.8 3590.9 0 0 75396 2 /kinetics/dendgeom red black 132 9 0 simundump kenz /kinetics/chain/kinetics[32]/PKC-active/PKC-act-raf 1 \ 0.0011493 0.0011493 86.652 86.652 75396 1.3263e-05 16 4 0 0 "" red yellow \ "" 138 10 0 simundump kenz /kinetics/chain/kinetics[32]/PKC-active/PKC-inact-GAP 1 53.939 \ 53.939 6.778 6.778 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 136 13 0 simundump kenz /kinetics/chain/kinetics[32]/PKC-active/PKC-act-GEF 1 726.99 \ 726.99 91.354 91.354 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 141 20 0 simundump kpool /kinetics/chain/kinetics[32]/MAPK* 1 -1e-12 7.8539e-05 \ 7.8539e-05 5.9215 5.9215 0 0 75396 0 /kinetics/dendgeom orange yellow 145 1 \ 0 simundump kenz /kinetics/chain/kinetics[32]/MAPK*/MAPK*-feedback 1 3.6779e-08 \ 3.6779e-08 0.002773 0.002773 75396 2.5864e-05 40 10 0 0 "" red orange "" \ 142 10 0 simundump kreac /kinetics/chain/kinetics[32]/MAPK*/diff 0 0.101 0.001 "" \ white black 146 4 0 simundump group /kinetics/chain/kinetics[32]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 147 11 0 simundump kpool /kinetics/chain/kinetics[32]/MAPK/craf-1 0 0 0.48263 0.48263 \ 36388 36388 0 0 75396 0 /kinetics/dendgeom pink brown 138 8 0 simundump kreac /kinetics/chain/kinetics[32]/MAPK/craf-1/diff 0 0.101 0.001 \ "" white black 139 11 0 simundump kpool /kinetics/chain/kinetics[32]/MAPK/craf-1* 0 0 0.012007 \ 0.012007 905.28 905.28 0 0 75396 0 /kinetics/dendgeom pink brown 141 8 0 simundump kreac /kinetics/chain/kinetics[32]/MAPK/craf-1*/diff 0 0.101 0.001 \ "" white black 142 11 0 simundump kpool /kinetics/chain/kinetics[32]/MAPK/MAPKK 0 0 0.4946 0.4946 \ 37291 37291 0 0 75396 0 /kinetics/dendgeom pink brown 138 4 0 simundump kreac /kinetics/chain/kinetics[32]/MAPK/MAPKK/diff 0 0.101 0.001 "" \ white black 139 7 0 simundump kpool /kinetics/chain/kinetics[32]/MAPK/MAPK 0 -1e-12 3.5824 3.5824 \ 2.701e+05 2.701e+05 0 0 75396 0 /kinetics/dendgeom pink brown 138 1 0 simundump kreac /kinetics/chain/kinetics[32]/MAPK/MAPK/diff 0 0.101 0.001 "" \ white black 139 4 0 simundump kpool /kinetics/chain/kinetics[32]/MAPK/craf-1** 1 0 9.6059e-07 \ 9.6059e-07 0.072425 0.072425 0 0 75396 0 /kinetics/dendgeom hotpink brown \ 144 8 0 simundump kreac /kinetics/chain/kinetics[32]/MAPK/craf-1**/diff 0 0.101 0.001 \ "" white black 145 11 0 simundump kpool /kinetics/chain/kinetics[32]/MAPK/MAPK-tyr 1 -1e-12 0.016774 \ 0.016774 1264.7 1264.7 0 0 75396 0 /kinetics/dendgeom orange brown 141 1 0 simundump kreac /kinetics/chain/kinetics[32]/MAPK/MAPK-tyr/diff 0 0.101 0.001 \ "" white black 142 4 0 simundump kpool /kinetics/chain/kinetics[32]/MAPK/MAPKK* 0 0 8.2386e-06 \ 8.2386e-06 0.62116 0.62116 0 0 75396 0 /kinetics/dendgeom pink brown 145 4 \ 0 simundump kenz /kinetics/chain/kinetics[32]/MAPK/MAPKK*/MAPKKtyr 0 0.00063751 \ 0.00063751 48.066 48.066 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 140 3 \ 0 simundump kenz /kinetics/chain/kinetics[32]/MAPK/MAPKK*/MAPKKthr 1 2.985e-06 \ 2.985e-06 0.22506 0.22506 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 145 3 \ 0 simundump kreac /kinetics/chain/kinetics[32]/MAPK/MAPKK*/diff 0 0.101 0.001 \ "" white black 146 7 0 simundump kpool /kinetics/chain/kinetics[32]/MAPK/MAPKK-ser 1 0 0.0020188 \ 0.0020188 152.21 152.21 0 0 75396 0 /kinetics/dendgeom pink brown 141 4 0 simundump kreac /kinetics/chain/kinetics[32]/MAPK/MAPKK-ser/diff 0 0.101 \ 0.001 "" white black 142 7 0 simundump kpool /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 137 6 0 simundump kenz /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 140 6 0 simundump kenz /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 143 6 0 simundump kreac /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras/diff 0 0.101 \ 0.001 "" white black 138 9 0 simundump kpool /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras 1 0 0.00082874 \ 0.00082874 62.484 62.484 0 0 75396 0 /kinetics/dendgeom red brown 137 5 0 simundump kenz /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 1545.9 1545.9 194.26 194.26 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" \ 140 5 0 simundump kenz /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 6.3096 6.3096 0.79287 0.79287 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" \ 143 5 0 simundump kreac /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras/diff 0 0.101 \ 0.001 "" white black 138 8 0 simundump kpool /kinetics/chain/kinetics[32]/MKP-1 1 -1e-12 0.019951 0.019951 \ 1504.2 1504.2 0 0 75396 0 /kinetics/dendgeom hotpink black 137 2 0 simundump kenz /kinetics/chain/kinetics[32]/MKP-1/MKP1-tyr-deph 1 4.781e-05 \ 4.781e-05 3.6047 3.6047 75396 3.7895e-05 16 4 0 0 "" red hotpink "" 138 3 0 simundump kenz 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-1e-12 0.0048465 \ 0.0048465 365.41 365.41 0 0 75396 0 /kinetics/dendgeom hotpink blue 138.45 \ 17.246 0 simundump kenz /kinetics/chain/kinetics[32]/Ras/GEF*/GEF*-act-ras 1 0.0046465 \ 0.0046465 350.33 350.33 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" \ 139.09 16.086 0 simundump kreac /kinetics/chain/kinetics[32]/Ras/GEF*/diff 0 0.101 0.001 "" \ white black 139.45 20.246 0 simundump kpool /kinetics/chain/kinetics[32]/Ras/GTP-Ras 1 0 0.0034512 \ 0.0034512 260.21 260.21 0 0 75396 0 /kinetics/dendgeom orange blue 144.56 \ 13.084 0 simundump kreac /kinetics/chain/kinetics[32]/Ras/GTP-Ras/diff 0 0.101 0.001 \ "" white black 145.56 16.084 0 simundump kpool /kinetics/chain/kinetics[32]/Ras/GDP-Ras 1 0 0.48419 0.48419 \ 36506 36506 0 0 75396 0 /kinetics/dendgeom pink blue 138.13 14.165 0 simundump kreac /kinetics/chain/kinetics[32]/Ras/GDP-Ras/diff 0 0.101 0.001 \ "" white black 139.13 17.165 0 simundump kreac /kinetics/chain/kinetics[32]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 141.1 13.5 0 simundump kreac /kinetics/chain/kinetics[32]/Ras/dephosph-GAP 1 0.1 0 "" \ white blue 136.02 15.524 0 simundump kpool /kinetics/chain/kinetics[32]/Ras/GAP* 1 -1e-12 0.0035959 \ 0.0035959 271.12 271.12 0 0 75396 0 /kinetics/dendgeom red blue 133.35 \ 14.349 0 simundump kreac /kinetics/chain/kinetics[32]/Ras/GAP*/diff 0 0.101 0.001 "" \ white black 134.35 17.349 0 simundump kpool /kinetics/chain/kinetics[32]/Ras/GAP 1 -1e-12 0.0062918 \ 0.0062918 474.38 474.38 0 0 75396 0 /kinetics/dendgeom red blue 138.65 \ 12.338 0 simundump kenz /kinetics/chain/kinetics[32]/Ras/GAP/GAP-inact-ras 1 \ 2.1491e-05 2.1491e-05 1.6203 1.6203 75396 0.00065634 40 10 0 0 "" red red \ "" 141.01 12.403 0 simundump kreac /kinetics/chain/kinetics[32]/Ras/GAP/diff 0 0.101 0.001 "" \ white black 139.65 15.338 0 simundump kreac /kinetics/chain/kinetics[32]/Ras/CaM-bind-GEF 1 0.0026526 1 \ "" white blue 134.49 21.679 0 simundump kpool /kinetics/chain/kinetics[32]/Ras/CaM-GEF 1 -1e-12 0.00021398 \ 0.00021398 16.133 16.133 0 0 75396 0 /kinetics/dendgeom pink blue 137.35 \ 19.58 0 simundump kenz /kinetics/chain/kinetics[32]/Ras/CaM-GEF/CaM-GEF-act-ras 1 \ 0.00020513 0.00020513 15.466 15.466 75396 2.6261e-05 0.8 0.2 0 0 "" red \ pink "" 137.02 18.657 0 simundump kreac /kinetics/chain/kinetics[32]/Ras/CaM-GEF/diff 0 0.101 0.001 \ "" white black 138.35 22.58 0 simundump group /kinetics/chain/kinetics[32]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 122 21 0 simundump kpool /kinetics/chain/kinetics[32]/CaM/CaM 1 -1e-12 18.403 18.403 \ 1.3875e+06 1.3875e+06 0 0 75396 0 /kinetics/dendgeom pink blue 119 30 0 simundump kreac /kinetics/chain/kinetics[32]/CaM/CaM/diff 0 0.101 0.001 "" \ white black 120 33 0 simundump kreac /kinetics/chain/kinetics[32]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 121.6 23.26 0 simundump kpool /kinetics/chain/kinetics[32]/CaM/CaM-Ca3 1 -1e-12 0.0033914 \ 0.0033914 255.7 255.7 0 0 75396 0 /kinetics/dendgeom hotpink blue 125.49 \ 24.397 0 simundump kreac /kinetics/chain/kinetics[32]/CaM/CaM-Ca3/diff 0 0.101 0.001 \ "" white black 126.49 27.397 0 simundump kpool /kinetics/chain/kinetics[32]/CaM/CaM-Ca4 1 -1e-12 1.2616e-05 \ 1.2616e-05 0.95122 0.95122 0 0 75396 0 /kinetics/dendgeom blue blue 130 24 \ 0 simundump kreac /kinetics/chain/kinetics[32]/CaM/CaM-Ca4/diff 0 0.101 0.001 \ "" white black 131 27 0 simundump kreac /kinetics/chain/kinetics[32]/CaM/CaM-bind-Ca 1 0.00011254 \ 8.4853 "" white blue 122 30 0 simundump kpool /kinetics/chain/kinetics[32]/CaM/CaM-Ca2 1 -1e-12 0.11776 \ 0.11776 8878.5 8878.5 0 0 75396 0 /kinetics/dendgeom pink blue 127 27.258 0 simundump kreac /kinetics/chain/kinetics[32]/CaM/CaM-Ca2/diff 0 0.101 0.001 \ "" white black 128 30.258 0 simundump kreac /kinetics/chain/kinetics[32]/CaM/CaM-Ca2-bind-Ca 1 4.7748e-05 \ 10 "" white blue 123.16 26.225 0 simundump kreac /kinetics/chain/kinetics[32]/CaM/CaM-Ca-bind-Ca 1 0.00011254 \ 8.4853 "" white blue 128 30 0 simundump kpool 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/kinetics/chain/kinetics[32]/PKM/PKM_synthesis 0 -1e-12 \ 0.0010085 0.0010085 76.04 76.04 0 0 75396 0 /kinetics/dendgeom 8 25 121 9 0 simundump kenz /kinetics/chain/kinetics[32]/PKM/PKM_synthesis/kenz 0 \ 0.00010086 0.00010086 7.6041 7.6041 75396 3.3159e-07 0.2 0.05 0 0 "" red 8 \ "" 122 10 0 simundump kreac /kinetics/chain/kinetics[32]/PKM/PKM_synthesis/diff 0 0.101 \ 0.001 "" white black 122 12 0 simundump kpool /kinetics/chain/kinetics[32]/PKM/AA_pool 0 -1e-12 1 1 75396 \ 75396 0 0 75396 4 /kinetics/dendgeom 9 25 125 12 0 simundump kreac /kinetics/chain/kinetics[32]/PKM/PKM_degradation 0 0.0005 0 \ "" white 25 124 7 0 simundump kpool /kinetics/chain/kinetics[32]/PKM/degraded_PKM 0 -1e-12 0 0 0 \ 0 0 0 75396 4 /kinetics/dendgeom 7 25 120 5 0 simundump kpool /kinetics/chain/kinetics[32]/PKM/Ca.detector_complex 0 -1e-12 \ 0.00012615 0.00012615 9.5109 9.5109 0 0 75396 0 /kinetics/dendgeom 7 25 120 \ 14 0 simundump kenz /kinetics/chain/kinetics[32]/PKM/Ca.detector_complex/kenz 0 \ 5.0428e-06 5.0428e-06 0.38021 0.38021 75396 2.6526e-06 0.8 0.2 0 0 "" red 7 \ "" 120 13 0 simundump kreac /kinetics/chain/kinetics[32]/PKM/Ca.detector_complex/diff 0 \ 0.101 0.001 "" white black 121 17 0 simundump kpool /kinetics/chain/kinetics[32]/PKM/PKM_activator 0 -1e-12 \ 0.19988 0.19988 15070 15070 0 0 75396 0 /kinetics/dendgeom 6 25 117 12 0 simundump kreac /kinetics/chain/kinetics[32]/PKM/PKM_activator/diff 0 0.101 \ 0.001 "" white black 118 15 0 simundump kreac /kinetics/chain/kinetics[32]/PKM/turn_off_activator 0 0.001 0 \ "" white 25 115 9 0 simundump kreac /kinetics/chain/kinetics[32]/PKM/trigger_PKM 0 0.00013263 1 \ "" white 25 115 16 0 simundump kpool /kinetics/chain/kinetics[32]/Ca_input 0 0 0.08 0.08 6031.7 \ 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 114 30 0 simundump kreac /kinetics/chain/kinetics[32]/Ca_diff 0 5 5 "" white black 114 \ 26 0 simundump group /kinetics/chain/kinetics[33] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 136 0 0 simundump group /kinetics/chain/kinetics[33]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 132.95 8.2163 0 simundump kpool /kinetics/chain/kinetics[33]/PKC/PKC-Ca 0 -1e-12 0.078942 \ 0.078942 5951.9 5951.9 0 0 75396 0 /kinetics/dendgeom red black 131.92 \ 1.5108 0 simundump kreac /kinetics/chain/kinetics[33]/PKC/PKC-Ca/diff 0 0.101 0.001 "" \ white black 132.92 4.5108 0 simundump kreac /kinetics/chain/kinetics[33]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 131.92 -0.12295 0 simundump kreac /kinetics/chain/kinetics[33]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 133.94 0.69395 0 simundump kreac /kinetics/chain/kinetics[33]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 132.2 4.2533 0 simundump kreac /kinetics/chain/kinetics[33]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 133.38 2.7362 0 simundump kpool /kinetics/chain/kinetics[33]/PKC/PKC-Ca-memb* 0 -1e-12 \ 0.028634 0.028634 2158.9 2158.9 0 0 75396 0 /kinetics/dendgeom pink blue \ 133.22 6.529 0 simundump kreac 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0.101 \ 0.001 "" white black 122 15 0 simundump kreac /kinetics/chain/kinetics[33]/PKM/turn_off_activator 0 0.001 0 \ "" white 25 119 9 0 simundump kreac /kinetics/chain/kinetics[33]/PKM/trigger_PKM 0 0.00013263 1 \ "" white 25 119 16 0 simundump kpool /kinetics/chain/kinetics[33]/Ca_input 0 0 0.08 0.08 6031.7 \ 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 118 30 0 simundump kreac /kinetics/chain/kinetics[33]/Ca_diff 0 5 5 "" white black 118 \ 26 0 simundump group /kinetics/chain/kinetics[34] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 140 0 0 simundump group /kinetics/chain/kinetics[34]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 136.95 8.2163 0 simundump kpool /kinetics/chain/kinetics[34]/PKC/PKC-Ca 0 -1e-12 0.078942 \ 0.078942 5951.9 5951.9 0 0 75396 0 /kinetics/dendgeom red black 135.92 \ 1.5108 0 simundump kreac /kinetics/chain/kinetics[34]/PKC/PKC-Ca/diff 0 0.101 0.001 "" \ white black 136.92 4.5108 0 simundump kreac 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kpool /kinetics/chain/kinetics[34]/PKC/PKC-Ca-DAG 0 -1e-12 \ 0.00089226 0.00089226 67.273 67.273 0 0 75396 0 /kinetics/dendgeom white \ blue 140.23 1.8026 0 simundump kreac /kinetics/chain/kinetics[34]/PKC/PKC-Ca-DAG/diff 0 0.101 \ 0.001 "" white black 141.23 4.8026 0 simundump kreac /kinetics/chain/kinetics[34]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 136.99 -1.9902 0 simundump kpool /kinetics/chain/kinetics[34]/PKC/PKC-DAG 0 -1e-12 0.060193 \ 0.060193 4538.3 4538.3 0 0 75396 0 /kinetics/dendgeom white blue 139 \ -1.0857 0 simundump kreac /kinetics/chain/kinetics[34]/PKC/PKC-DAG/diff 0 0.101 0.001 \ "" white black 140 1.9143 0 simundump kpool /kinetics/chain/kinetics[34]/PKC/PKC-cytosolic 0 -1e-12 \ 0.8223 0.8223 61998 61998 0 0 75396 0 /kinetics/dendgeom white blue 133.87 \ 0.59711 0 simundump kreac /kinetics/chain/kinetics[34]/PKC/PKC-cytosolic/diff 0 0.101 \ 0.001 "" white black 134.87 3.5971 0 simundump kpool /kinetics/chain/kinetics[34]/PKC/PKM-zeta 0 -1e-12 0.01007 \ 0.01007 759.21 759.21 0 0 75396 0 /kinetics/dendgeom cyan blue 137 11 0 simundump kreac /kinetics/chain/kinetics[34]/PKC/PKM-zeta/diff 0 0.101 0.001 \ "" white black 138 14 0 simundump kpool /kinetics/chain/kinetics[34]/DAG 1 -1e-12 12.2 12.2 \ 9.1983e+05 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 144 -3 0 simundump kpool /kinetics/chain/kinetics[34]/PKC-active 1 -1e-12 0.047627 \ 0.047626 3590.8 3590.9 0 0 75396 2 /kinetics/dendgeom red black 140 9 0 simundump kenz /kinetics/chain/kinetics[34]/PKC-active/PKC-act-raf 1 \ 0.0011493 0.0011493 86.652 86.652 75396 1.3263e-05 16 4 0 0 "" red yellow \ "" 146 10 0 simundump kenz /kinetics/chain/kinetics[34]/PKC-active/PKC-inact-GAP 1 53.939 \ 53.939 6.778 6.778 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 144 13 0 simundump kenz /kinetics/chain/kinetics[34]/PKC-active/PKC-act-GEF 1 726.99 \ 726.99 91.354 91.354 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 149 20 0 simundump kpool /kinetics/chain/kinetics[34]/MAPK* 1 -1e-12 7.8539e-05 \ 7.8539e-05 5.9215 5.9215 0 0 75396 0 /kinetics/dendgeom orange yellow 153 1 \ 0 simundump kenz /kinetics/chain/kinetics[34]/MAPK*/MAPK*-feedback 1 3.6779e-08 \ 3.6779e-08 0.002773 0.002773 75396 2.5864e-05 40 10 0 0 "" red orange "" \ 150 10 0 simundump kreac /kinetics/chain/kinetics[34]/MAPK*/diff 0 0.101 0.001 "" \ white black 154 4 0 simundump group /kinetics/chain/kinetics[34]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 155 11 0 simundump kpool /kinetics/chain/kinetics[34]/MAPK/craf-1 0 0 0.48263 0.48263 \ 36388 36388 0 0 75396 0 /kinetics/dendgeom pink brown 146 8 0 simundump kreac /kinetics/chain/kinetics[34]/MAPK/craf-1/diff 0 0.101 0.001 \ "" white black 147 11 0 simundump kpool /kinetics/chain/kinetics[34]/MAPK/craf-1* 0 0 0.012007 \ 0.012007 905.28 905.28 0 0 75396 0 /kinetics/dendgeom pink brown 149 8 0 simundump kreac /kinetics/chain/kinetics[34]/MAPK/craf-1*/diff 0 0.101 0.001 \ "" white black 150 11 0 simundump kpool /kinetics/chain/kinetics[34]/MAPK/MAPKK 0 0 0.4946 0.4946 \ 37291 37291 0 0 75396 0 /kinetics/dendgeom pink brown 146 4 0 simundump kreac /kinetics/chain/kinetics[34]/MAPK/MAPKK/diff 0 0.101 0.001 "" \ white black 147 7 0 simundump kpool /kinetics/chain/kinetics[34]/MAPK/MAPK 0 -1e-12 3.5824 3.5824 \ 2.701e+05 2.701e+05 0 0 75396 0 /kinetics/dendgeom pink brown 146 1 0 simundump kreac /kinetics/chain/kinetics[34]/MAPK/MAPK/diff 0 0.101 0.001 "" \ white black 147 4 0 simundump kpool /kinetics/chain/kinetics[34]/MAPK/craf-1** 1 0 9.6059e-07 \ 9.6059e-07 0.072425 0.072425 0 0 75396 0 /kinetics/dendgeom hotpink brown \ 152 8 0 simundump kreac /kinetics/chain/kinetics[34]/MAPK/craf-1**/diff 0 0.101 0.001 \ "" white black 153 11 0 simundump kpool /kinetics/chain/kinetics[34]/MAPK/MAPK-tyr 1 -1e-12 0.016774 \ 0.016774 1264.7 1264.7 0 0 75396 0 /kinetics/dendgeom orange brown 149 1 0 simundump kreac /kinetics/chain/kinetics[34]/MAPK/MAPK-tyr/diff 0 0.101 0.001 \ "" white black 150 4 0 simundump kpool /kinetics/chain/kinetics[34]/MAPK/MAPKK* 0 0 8.2386e-06 \ 8.2386e-06 0.62116 0.62116 0 0 75396 0 /kinetics/dendgeom pink brown 153 4 \ 0 simundump kenz /kinetics/chain/kinetics[34]/MAPK/MAPKK*/MAPKKtyr 0 0.00063751 \ 0.00063751 48.066 48.066 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 148 3 \ 0 simundump kenz /kinetics/chain/kinetics[34]/MAPK/MAPKK*/MAPKKthr 1 2.985e-06 \ 2.985e-06 0.22506 0.22506 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 153 3 \ 0 simundump kreac /kinetics/chain/kinetics[34]/MAPK/MAPKK*/diff 0 0.101 0.001 \ "" white black 154 7 0 simundump kpool /kinetics/chain/kinetics[34]/MAPK/MAPKK-ser 1 0 0.0020188 \ 0.0020188 152.21 152.21 0 0 75396 0 /kinetics/dendgeom pink brown 149 4 0 simundump kreac /kinetics/chain/kinetics[34]/MAPK/MAPKK-ser/diff 0 0.101 \ 0.001 "" white black 150 7 0 simundump kpool /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 145 6 0 simundump kenz /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 148 6 0 simundump kenz /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 151 6 0 simundump kreac /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras/diff 0 0.101 \ 0.001 "" white black 146 9 0 simundump kpool /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras 1 0 0.00082874 \ 0.00082874 62.484 62.484 0 0 75396 0 /kinetics/dendgeom red brown 145 5 0 simundump kenz /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 1545.9 1545.9 194.26 194.26 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" \ 148 5 0 simundump kenz /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 6.3096 6.3096 0.79287 0.79287 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" \ 151 5 0 simundump kreac /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras/diff 0 0.101 \ 0.001 "" white black 146 8 0 simundump kpool /kinetics/chain/kinetics[34]/MKP-1 1 -1e-12 0.019951 0.019951 \ 1504.2 1504.2 0 0 75396 0 /kinetics/dendgeom hotpink black 145 2 0 simundump kenz /kinetics/chain/kinetics[34]/MKP-1/MKP1-tyr-deph 1 4.781e-05 \ 4.781e-05 3.6047 3.6047 75396 3.7895e-05 16 4 0 0 "" red hotpink "" 146 3 0 simundump kenz /kinetics/chain/kinetics[34]/MKP-1/MKP1-thr-deph 1 2.2386e-07 \ 2.2386e-07 0.016878 0.016878 75396 3.7895e-05 16 4 0 0 "" red hotpink "" \ 151 3 0 simundump kreac /kinetics/chain/kinetics[34]/MKP-1/diff 0 0.101 0.001 "" \ white black 146 5 0 simundump kreac /kinetics/chain/kinetics[34]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 143 9 0 simundump kpool /kinetics/chain/kinetics[34]/PPhosphatase2A 1 -1e-12 0.9991 \ 0.9991 75328 75328 0 0 75396 0 /kinetics/dendgeom hotpink yellow 149 9 0 simundump kenz /kinetics/chain/kinetics[34]/PPhosphatase2A/craf-deph 1 \ 0.00076621 0.00076621 57.769 57.769 75396 2.5414e-05 24 6 0 0 "" red \ hotpink "" 148 10 0 simundump kenz 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/kinetics/chain/kinetics[34]/Ras/inact-GEF/basal_GEF_activity 0 \ 0.0040648 0.0040648 306.47 306.47 75396 1.313e-07 0.08 0.02 0 0 "" red \ hotpink "" 152 17 0 simundump kreac /kinetics/chain/kinetics[34]/Ras/inact-GEF/diff 0 0.101 0.001 \ "" white black 153.45 21.352 0 simundump kpool /kinetics/chain/kinetics[34]/Ras/GEF* 1 -1e-12 0.0048465 \ 0.0048465 365.41 365.41 0 0 75396 0 /kinetics/dendgeom hotpink blue 146.45 \ 17.246 0 simundump kenz /kinetics/chain/kinetics[34]/Ras/GEF*/GEF*-act-ras 1 0.0046465 \ 0.0046465 350.33 350.33 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" \ 147.09 16.086 0 simundump kreac /kinetics/chain/kinetics[34]/Ras/GEF*/diff 0 0.101 0.001 "" \ white black 147.45 20.246 0 simundump kpool /kinetics/chain/kinetics[34]/Ras/GTP-Ras 1 0 0.0034512 \ 0.0034512 260.21 260.21 0 0 75396 0 /kinetics/dendgeom orange blue 152.56 \ 13.084 0 simundump kreac /kinetics/chain/kinetics[34]/Ras/GTP-Ras/diff 0 0.101 0.001 \ "" white black 153.56 16.084 0 simundump kpool /kinetics/chain/kinetics[34]/Ras/GDP-Ras 1 0 0.48419 0.48419 \ 36506 36506 0 0 75396 0 /kinetics/dendgeom pink blue 146.13 14.165 0 simundump kreac /kinetics/chain/kinetics[34]/Ras/GDP-Ras/diff 0 0.101 0.001 \ "" white black 147.13 17.165 0 simundump kreac /kinetics/chain/kinetics[34]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 149.1 13.5 0 simundump kreac /kinetics/chain/kinetics[34]/Ras/dephosph-GAP 1 0.1 0 "" \ white blue 144.02 15.524 0 simundump kpool /kinetics/chain/kinetics[34]/Ras/GAP* 1 -1e-12 0.0035959 \ 0.0035959 271.12 271.12 0 0 75396 0 /kinetics/dendgeom red blue 141.35 \ 14.349 0 simundump kreac /kinetics/chain/kinetics[34]/Ras/GAP*/diff 0 0.101 0.001 "" \ white black 142.35 17.349 0 simundump kpool /kinetics/chain/kinetics[34]/Ras/GAP 1 -1e-12 0.0062918 \ 0.0062918 474.38 474.38 0 0 75396 0 /kinetics/dendgeom red blue 146.65 \ 12.338 0 simundump kenz /kinetics/chain/kinetics[34]/Ras/GAP/GAP-inact-ras 1 \ 2.1491e-05 2.1491e-05 1.6203 1.6203 75396 0.00065634 40 10 0 0 "" red red \ "" 149.01 12.403 0 simundump kreac /kinetics/chain/kinetics[34]/Ras/GAP/diff 0 0.101 0.001 "" \ white black 147.65 15.338 0 simundump kreac /kinetics/chain/kinetics[34]/Ras/CaM-bind-GEF 1 0.0026526 1 \ "" white blue 142.49 21.679 0 simundump kpool /kinetics/chain/kinetics[34]/Ras/CaM-GEF 1 -1e-12 0.00021398 \ 0.00021398 16.133 16.133 0 0 75396 0 /kinetics/dendgeom pink blue 145.35 \ 19.58 0 simundump kenz /kinetics/chain/kinetics[34]/Ras/CaM-GEF/CaM-GEF-act-ras 1 \ 0.00020513 0.00020513 15.466 15.466 75396 2.6261e-05 0.8 0.2 0 0 "" red \ pink "" 145.02 18.657 0 simundump kreac /kinetics/chain/kinetics[34]/Ras/CaM-GEF/diff 0 0.101 0.001 \ "" white black 146.35 22.58 0 simundump group /kinetics/chain/kinetics[34]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 130 21 0 simundump kpool /kinetics/chain/kinetics[34]/CaM/CaM 1 -1e-12 18.403 18.403 \ 1.3875e+06 1.3875e+06 0 0 75396 0 /kinetics/dendgeom pink blue 127 30 0 simundump kreac /kinetics/chain/kinetics[34]/CaM/CaM/diff 0 0.101 0.001 "" \ white black 128 33 0 simundump kreac /kinetics/chain/kinetics[34]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 129.6 23.26 0 simundump kpool /kinetics/chain/kinetics[34]/CaM/CaM-Ca3 1 -1e-12 0.0033914 \ 0.0033914 255.7 255.7 0 0 75396 0 /kinetics/dendgeom hotpink blue 133.49 \ 24.397 0 simundump kreac /kinetics/chain/kinetics[34]/CaM/CaM-Ca3/diff 0 0.101 0.001 \ "" white black 134.49 27.397 0 simundump kpool /kinetics/chain/kinetics[34]/CaM/CaM-Ca4 1 -1e-12 1.2616e-05 \ 1.2616e-05 0.95122 0.95122 0 0 75396 0 /kinetics/dendgeom blue blue 138 24 \ 0 simundump kreac /kinetics/chain/kinetics[34]/CaM/CaM-Ca4/diff 0 0.101 0.001 \ "" white black 139 27 0 simundump kreac /kinetics/chain/kinetics[34]/CaM/CaM-bind-Ca 1 0.00011254 \ 8.4853 "" white blue 130 30 0 simundump kpool /kinetics/chain/kinetics[34]/CaM/CaM-Ca2 1 -1e-12 0.11776 \ 0.11776 8878.5 8878.5 0 0 75396 0 /kinetics/dendgeom pink blue 135 27.258 0 simundump kreac /kinetics/chain/kinetics[34]/CaM/CaM-Ca2/diff 0 0.101 0.001 \ "" white black 136 30.258 0 simundump kreac /kinetics/chain/kinetics[34]/CaM/CaM-Ca2-bind-Ca 1 4.7748e-05 \ 10 "" white blue 131.16 26.225 0 simundump kreac /kinetics/chain/kinetics[34]/CaM/CaM-Ca-bind-Ca 1 0.00011254 \ 8.4853 "" white blue 136 30 0 simundump kpool /kinetics/chain/kinetics[34]/CaM/CaM-Ca 1 -1e-12 1.472 1.472 \ 1.1098e+05 1.1098e+05 0 0 75396 0 /kinetics/dendgeom pink blue 133 31 0 simundump kreac /kinetics/chain/kinetics[34]/CaM/CaM-Ca/diff 0 0.101 0.001 "" \ white black 134 34 0 simundump kpool /kinetics/chain/kinetics[34]/Ca 1 -1e-12 0.08 0.08 6031.7 \ 6031.7 0 0 75396 0 /kinetics/dendgeom red black 122 23 0 simundump kreac /kinetics/chain/kinetics[34]/Ca/diff 0 0.101 0.001 "" white \ black 123 26 0 simundump kreac /kinetics/chain/kinetics[34]/Ras-act-unphosph-raf 0 0 0 "" \ white black 144 8 0 simundump group /kinetics/chain/kinetics[34]/PKM 0 25 black x 0 0 "" PKM \ defaultfile.g 0 5dc016e940e88c1cc7928f4e096ff523 0 133 19 0 simundump kpool /kinetics/chain/kinetics[34]/PKM/Ca_detector 0 -1e-12 0.99987 \ 0.99987 75386 75386 0 0 75396 0 /kinetics/dendgeom 7 25 129 17 0 simundump kreac /kinetics/chain/kinetics[34]/PKM/Ca_detector/diff 0 0.101 \ 0.001 "" white black 130 20 0 simundump kpool /kinetics/chain/kinetics[34]/PKM/PKM_synthesis 0 -1e-12 \ 0.0010085 0.0010085 76.04 76.04 0 0 75396 0 /kinetics/dendgeom 8 25 129 9 0 simundump kenz /kinetics/chain/kinetics[34]/PKM/PKM_synthesis/kenz 0 \ 0.00010086 0.00010086 7.6041 7.6041 75396 3.3159e-07 0.2 0.05 0 0 "" red 8 \ "" 130 10 0 simundump kreac /kinetics/chain/kinetics[34]/PKM/PKM_synthesis/diff 0 0.101 \ 0.001 "" white black 130 12 0 simundump kpool /kinetics/chain/kinetics[34]/PKM/AA_pool 0 -1e-12 1 1 75396 \ 75396 0 0 75396 4 /kinetics/dendgeom 9 25 133 12 0 simundump kreac /kinetics/chain/kinetics[34]/PKM/PKM_degradation 0 0.0005 0 \ "" white 25 132 7 0 simundump kpool /kinetics/chain/kinetics[34]/PKM/degraded_PKM 0 -1e-12 0 0 0 \ 0 0 0 75396 4 /kinetics/dendgeom 7 25 128 5 0 simundump kpool /kinetics/chain/kinetics[34]/PKM/Ca.detector_complex 0 -1e-12 \ 0.00012615 0.00012615 9.5109 9.5109 0 0 75396 0 /kinetics/dendgeom 7 25 128 \ 14 0 simundump kenz /kinetics/chain/kinetics[34]/PKM/Ca.detector_complex/kenz 0 \ 5.0428e-06 5.0428e-06 0.38021 0.38021 75396 2.6526e-06 0.8 0.2 0 0 "" red 7 \ "" 128 13 0 simundump kreac /kinetics/chain/kinetics[34]/PKM/Ca.detector_complex/diff 0 \ 0.101 0.001 "" white black 129 17 0 simundump kpool /kinetics/chain/kinetics[34]/PKM/PKM_activator 0 -1e-12 \ 0.19988 0.19988 15070 15070 0 0 75396 0 /kinetics/dendgeom 6 25 125 12 0 simundump kreac /kinetics/chain/kinetics[34]/PKM/PKM_activator/diff 0 0.101 \ 0.001 "" white black 126 15 0 simundump kreac /kinetics/chain/kinetics[34]/PKM/turn_off_activator 0 0.001 0 \ "" white 25 123 9 0 simundump kreac /kinetics/chain/kinetics[34]/PKM/trigger_PKM 0 0.00013263 1 \ "" white 25 123 16 0 simundump kpool /kinetics/chain/kinetics[34]/Ca_input 0 0 0.08 0.08 6031.7 \ 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 122 30 0 simundump kreac /kinetics/chain/kinetics[34]/Ca_diff 0 5 5 "" white black 122 \ 26 0 simundump group /kinetics/chain/kinetics[35] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 144 0 0 simundump group /kinetics/chain/kinetics[35]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 140.95 8.2163 0 simundump kpool /kinetics/chain/kinetics[35]/PKC/PKC-Ca 0 -1e-12 0.078942 \ 0.078942 5951.9 5951.9 0 0 75396 0 /kinetics/dendgeom red black 139.92 \ 1.5108 0 simundump kreac /kinetics/chain/kinetics[35]/PKC/PKC-Ca/diff 0 0.101 0.001 "" \ white black 140.92 4.5108 0 simundump kreac /kinetics/chain/kinetics[35]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 139.92 -0.12295 0 simundump kreac /kinetics/chain/kinetics[35]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 141.94 0.69395 0 simundump kreac 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\ 0.001 "" white black 145.23 4.8026 0 simundump kreac /kinetics/chain/kinetics[35]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 140.99 -1.9902 0 simundump kpool /kinetics/chain/kinetics[35]/PKC/PKC-DAG 0 -1e-12 0.060193 \ 0.060193 4538.3 4538.3 0 0 75396 0 /kinetics/dendgeom white blue 143 \ -1.0857 0 simundump kreac /kinetics/chain/kinetics[35]/PKC/PKC-DAG/diff 0 0.101 0.001 \ "" white black 144 1.9143 0 simundump kpool /kinetics/chain/kinetics[35]/PKC/PKC-cytosolic 0 -1e-12 \ 0.8223 0.8223 61998 61998 0 0 75396 0 /kinetics/dendgeom white blue 137.87 \ 0.59711 0 simundump kreac /kinetics/chain/kinetics[35]/PKC/PKC-cytosolic/diff 0 0.101 \ 0.001 "" white black 138.87 3.5971 0 simundump kpool /kinetics/chain/kinetics[35]/PKC/PKM-zeta 0 -1e-12 0.01007 \ 0.01007 759.21 759.21 0 0 75396 0 /kinetics/dendgeom cyan blue 141 11 0 simundump kreac /kinetics/chain/kinetics[35]/PKC/PKM-zeta/diff 0 0.101 0.001 \ "" white black 142 14 0 simundump kpool /kinetics/chain/kinetics[35]/DAG 1 -1e-12 12.2 12.2 \ 9.1983e+05 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 148 -3 0 simundump kpool /kinetics/chain/kinetics[35]/PKC-active 1 -1e-12 0.047627 \ 0.047626 3590.8 3590.9 0 0 75396 2 /kinetics/dendgeom red black 144 9 0 simundump kenz /kinetics/chain/kinetics[35]/PKC-active/PKC-act-raf 1 \ 0.0011493 0.0011493 86.652 86.652 75396 1.3263e-05 16 4 0 0 "" red yellow \ "" 150 10 0 simundump kenz /kinetics/chain/kinetics[35]/PKC-active/PKC-inact-GAP 1 53.939 \ 53.939 6.778 6.778 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 148 13 0 simundump kenz /kinetics/chain/kinetics[35]/PKC-active/PKC-act-GEF 1 726.99 \ 726.99 91.354 91.354 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 153 20 0 simundump kpool /kinetics/chain/kinetics[35]/MAPK* 1 -1e-12 7.8539e-05 \ 7.8539e-05 5.9215 5.9215 0 0 75396 0 /kinetics/dendgeom orange yellow 157 1 \ 0 simundump kenz /kinetics/chain/kinetics[35]/MAPK*/MAPK*-feedback 1 3.6779e-08 \ 3.6779e-08 0.002773 0.002773 75396 2.5864e-05 40 10 0 0 "" red orange 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0.00021398 16.133 16.133 0 0 75396 0 /kinetics/dendgeom pink blue 149.35 \ 19.58 0 simundump kenz /kinetics/chain/kinetics[35]/Ras/CaM-GEF/CaM-GEF-act-ras 1 \ 0.00020513 0.00020513 15.466 15.466 75396 2.6261e-05 0.8 0.2 0 0 "" red \ pink "" 149.02 18.657 0 simundump kreac /kinetics/chain/kinetics[35]/Ras/CaM-GEF/diff 0 0.101 0.001 \ "" white black 150.35 22.58 0 simundump group /kinetics/chain/kinetics[35]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 134 21 0 simundump kpool /kinetics/chain/kinetics[35]/CaM/CaM 1 -1e-12 18.403 18.403 \ 1.3875e+06 1.3875e+06 0 0 75396 0 /kinetics/dendgeom pink blue 131 30 0 simundump kreac /kinetics/chain/kinetics[35]/CaM/CaM/diff 0 0.101 0.001 "" \ white black 132 33 0 simundump kreac /kinetics/chain/kinetics[35]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 133.6 23.26 0 simundump kpool /kinetics/chain/kinetics[35]/CaM/CaM-Ca3 1 -1e-12 0.0033914 \ 0.0033914 255.7 255.7 0 0 75396 0 /kinetics/dendgeom hotpink blue 137.49 \ 24.397 0 simundump kreac /kinetics/chain/kinetics[35]/CaM/CaM-Ca3/diff 0 0.101 0.001 \ "" white black 138.49 27.397 0 simundump kpool /kinetics/chain/kinetics[35]/CaM/CaM-Ca4 1 -1e-12 1.2616e-05 \ 1.2616e-05 0.95122 0.95122 0 0 75396 0 /kinetics/dendgeom blue blue 142 24 \ 0 simundump kreac /kinetics/chain/kinetics[35]/CaM/CaM-Ca4/diff 0 0.101 0.001 \ "" white black 143 27 0 simundump kreac /kinetics/chain/kinetics[35]/CaM/CaM-bind-Ca 1 0.00011254 \ 8.4853 "" white blue 134 30 0 simundump kpool /kinetics/chain/kinetics[35]/CaM/CaM-Ca2 1 -1e-12 0.11776 \ 0.11776 8878.5 8878.5 0 0 75396 0 /kinetics/dendgeom pink blue 139 27.258 0 simundump kreac /kinetics/chain/kinetics[35]/CaM/CaM-Ca2/diff 0 0.101 0.001 \ "" white black 140 30.258 0 simundump kreac /kinetics/chain/kinetics[35]/CaM/CaM-Ca2-bind-Ca 1 4.7748e-05 \ 10 "" white blue 135.16 26.225 0 simundump kreac /kinetics/chain/kinetics[35]/CaM/CaM-Ca-bind-Ca 1 0.00011254 \ 8.4853 "" white blue 140 30 0 simundump kpool 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5.0428e-06 5.0428e-06 0.38021 0.38021 75396 2.6526e-06 0.8 0.2 0 0 "" red 7 \ "" 132 13 0 simundump kreac /kinetics/chain/kinetics[35]/PKM/Ca.detector_complex/diff 0 \ 0.101 0.001 "" white black 133 17 0 simundump kpool /kinetics/chain/kinetics[35]/PKM/PKM_activator 0 -1e-12 \ 0.19988 0.19988 15070 15070 0 0 75396 0 /kinetics/dendgeom 6 25 129 12 0 simundump kreac /kinetics/chain/kinetics[35]/PKM/PKM_activator/diff 0 0.101 \ 0.001 "" white black 130 15 0 simundump kreac /kinetics/chain/kinetics[35]/PKM/turn_off_activator 0 0.001 0 \ "" white 25 127 9 0 simundump kreac /kinetics/chain/kinetics[35]/PKM/trigger_PKM 0 0.00013263 1 \ "" white 25 127 16 0 simundump kpool /kinetics/chain/kinetics[35]/Ca_input 0 0 0.08 0.08 6031.7 \ 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 126 30 0 simundump kreac /kinetics/chain/kinetics[35]/Ca_diff 0 5 5 "" white black 126 \ 26 0 simundump group /kinetics/chain/kinetics[36] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 148 0 0 simundump 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0.101 \ 0.001 "" white black 134 15 0 simundump kreac /kinetics/chain/kinetics[36]/PKM/turn_off_activator 0 0.001 0 \ "" white 25 131 9 0 simundump kreac /kinetics/chain/kinetics[36]/PKM/trigger_PKM 0 0.00013263 1 \ "" white 25 131 16 0 simundump kpool /kinetics/chain/kinetics[36]/Ca_input 0 0 0.08 0.08 6031.7 \ 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 130 30 0 simundump kreac /kinetics/chain/kinetics[36]/Ca_diff 0 5 5 "" white black 130 \ 26 0 simundump group /kinetics/chain/kinetics[37] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 152 0 0 simundump group /kinetics/chain/kinetics[37]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 148.95 8.2163 0 simundump kpool /kinetics/chain/kinetics[37]/PKC/PKC-Ca 0 -1e-12 0.078942 \ 0.078942 5951.9 5951.9 0 0 75396 0 /kinetics/dendgeom red black 147.92 \ 1.5108 0 simundump kreac /kinetics/chain/kinetics[37]/PKC/PKC-Ca/diff 0 0.101 0.001 "" \ white black 148.92 4.5108 0 simundump kreac 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0.01007 759.21 759.21 0 0 75396 0 /kinetics/dendgeom cyan blue 149 11 0 simundump kreac /kinetics/chain/kinetics[37]/PKC/PKM-zeta/diff 0 0.101 0.001 \ "" white black 150 14 0 simundump kpool /kinetics/chain/kinetics[37]/DAG 1 -1e-12 12.2 12.2 \ 9.1983e+05 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 156 -3 0 simundump kpool /kinetics/chain/kinetics[37]/PKC-active 1 -1e-12 0.047627 \ 0.047626 3590.8 3590.9 0 0 75396 2 /kinetics/dendgeom red black 152 9 0 simundump kenz /kinetics/chain/kinetics[37]/PKC-active/PKC-act-raf 1 \ 0.0011493 0.0011493 86.652 86.652 75396 1.3263e-05 16 4 0 0 "" red yellow \ "" 158 10 0 simundump kenz /kinetics/chain/kinetics[37]/PKC-active/PKC-inact-GAP 1 53.939 \ 53.939 6.778 6.778 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 156 13 0 simundump kenz /kinetics/chain/kinetics[37]/PKC-active/PKC-act-GEF 1 726.99 \ 726.99 91.354 91.354 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 161 20 0 simundump kpool /kinetics/chain/kinetics[37]/MAPK* 1 -1e-12 7.8539e-05 \ 7.8539e-05 5.9215 5.9215 0 0 75396 0 /kinetics/dendgeom orange yellow 165 1 \ 0 simundump kenz /kinetics/chain/kinetics[37]/MAPK*/MAPK*-feedback 1 3.6779e-08 \ 3.6779e-08 0.002773 0.002773 75396 2.5864e-05 40 10 0 0 "" red orange "" \ 162 10 0 simundump kreac /kinetics/chain/kinetics[37]/MAPK*/diff 0 0.101 0.001 "" \ white black 166 4 0 simundump group /kinetics/chain/kinetics[37]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 167 11 0 simundump kpool /kinetics/chain/kinetics[37]/MAPK/craf-1 0 0 0.48263 0.48263 \ 36388 36388 0 0 75396 0 /kinetics/dendgeom pink brown 158 8 0 simundump kreac /kinetics/chain/kinetics[37]/MAPK/craf-1/diff 0 0.101 0.001 \ "" white black 159 11 0 simundump kpool /kinetics/chain/kinetics[37]/MAPK/craf-1* 0 0 0.012007 \ 0.012007 905.28 905.28 0 0 75396 0 /kinetics/dendgeom pink brown 161 8 0 simundump kreac /kinetics/chain/kinetics[37]/MAPK/craf-1*/diff 0 0.101 0.001 \ "" white black 162 11 0 simundump kpool 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0 0 "" red red \ "" 161.01 12.403 0 simundump kreac /kinetics/chain/kinetics[37]/Ras/GAP/diff 0 0.101 0.001 "" \ white black 159.65 15.338 0 simundump kreac /kinetics/chain/kinetics[37]/Ras/CaM-bind-GEF 1 0.0026526 1 \ "" white blue 154.49 21.679 0 simundump kpool /kinetics/chain/kinetics[37]/Ras/CaM-GEF 1 -1e-12 0.00021398 \ 0.00021398 16.133 16.133 0 0 75396 0 /kinetics/dendgeom pink blue 157.35 \ 19.58 0 simundump kenz /kinetics/chain/kinetics[37]/Ras/CaM-GEF/CaM-GEF-act-ras 1 \ 0.00020513 0.00020513 15.466 15.466 75396 2.6261e-05 0.8 0.2 0 0 "" red \ pink "" 157.02 18.657 0 simundump kreac /kinetics/chain/kinetics[37]/Ras/CaM-GEF/diff 0 0.101 0.001 \ "" white black 158.35 22.58 0 simundump group /kinetics/chain/kinetics[37]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 142 21 0 simundump kpool /kinetics/chain/kinetics[37]/CaM/CaM 1 -1e-12 18.403 18.403 \ 1.3875e+06 1.3875e+06 0 0 75396 0 /kinetics/dendgeom pink blue 139 30 0 simundump kreac 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5dc016e940e88c1cc7928f4e096ff523 0 145 19 0 simundump kpool /kinetics/chain/kinetics[37]/PKM/Ca_detector 0 -1e-12 0.99987 \ 0.99987 75386 75386 0 0 75396 0 /kinetics/dendgeom 7 25 141 17 0 simundump kreac /kinetics/chain/kinetics[37]/PKM/Ca_detector/diff 0 0.101 \ 0.001 "" white black 142 20 0 simundump kpool /kinetics/chain/kinetics[37]/PKM/PKM_synthesis 0 -1e-12 \ 0.0010085 0.0010085 76.04 76.04 0 0 75396 0 /kinetics/dendgeom 8 25 141 9 0 simundump kenz /kinetics/chain/kinetics[37]/PKM/PKM_synthesis/kenz 0 \ 0.00010086 0.00010086 7.6041 7.6041 75396 3.3159e-07 0.2 0.05 0 0 "" red 8 \ "" 142 10 0 simundump kreac /kinetics/chain/kinetics[37]/PKM/PKM_synthesis/diff 0 0.101 \ 0.001 "" white black 142 12 0 simundump kpool /kinetics/chain/kinetics[37]/PKM/AA_pool 0 -1e-12 1 1 75396 \ 75396 0 0 75396 4 /kinetics/dendgeom 9 25 145 12 0 simundump kreac /kinetics/chain/kinetics[37]/PKM/PKM_degradation 0 0.0005 0 \ "" white 25 144 7 0 simundump kpool /kinetics/chain/kinetics[37]/PKM/degraded_PKM 0 -1e-12 0 0 0 \ 0 0 0 75396 4 /kinetics/dendgeom 7 25 140 5 0 simundump kpool /kinetics/chain/kinetics[37]/PKM/Ca.detector_complex 0 -1e-12 \ 0.00012615 0.00012615 9.5109 9.5109 0 0 75396 0 /kinetics/dendgeom 7 25 140 \ 14 0 simundump kenz /kinetics/chain/kinetics[37]/PKM/Ca.detector_complex/kenz 0 \ 5.0428e-06 5.0428e-06 0.38021 0.38021 75396 2.6526e-06 0.8 0.2 0 0 "" red 7 \ "" 140 13 0 simundump kreac /kinetics/chain/kinetics[37]/PKM/Ca.detector_complex/diff 0 \ 0.101 0.001 "" white black 141 17 0 simundump kpool /kinetics/chain/kinetics[37]/PKM/PKM_activator 0 -1e-12 \ 0.19988 0.19988 15070 15070 0 0 75396 0 /kinetics/dendgeom 6 25 137 12 0 simundump kreac /kinetics/chain/kinetics[37]/PKM/PKM_activator/diff 0 0.101 \ 0.001 "" white black 138 15 0 simundump kreac /kinetics/chain/kinetics[37]/PKM/turn_off_activator 0 0.001 0 \ "" white 25 135 9 0 simundump kreac /kinetics/chain/kinetics[37]/PKM/trigger_PKM 0 0.00013263 1 \ "" white 25 135 16 0 simundump kpool /kinetics/chain/kinetics[37]/Ca_input 0 0 0.08 0.08 6031.7 \ 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 134 30 0 simundump kreac /kinetics/chain/kinetics[37]/Ca_diff 0 5 5 "" white black 134 \ 26 0 simundump group /kinetics/chain/kinetics[38] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 156 0 0 simundump group /kinetics/chain/kinetics[38]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 152.95 8.2163 0 simundump kpool /kinetics/chain/kinetics[38]/PKC/PKC-Ca 0 -1e-12 0.078942 \ 0.078942 5951.9 5951.9 0 0 75396 4 /kinetics/dendgeom red black 151.92 \ 1.5108 0 simundump kreac /kinetics/chain/kinetics[38]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 151.92 -0.12295 0 simundump kreac /kinetics/chain/kinetics[38]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 153.94 0.69395 0 simundump kreac /kinetics/chain/kinetics[38]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 152.2 4.2533 0 simundump kreac /kinetics/chain/kinetics[38]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 153.38 2.7362 0 simundump kpool /kinetics/chain/kinetics[38]/PKC/PKC-Ca-memb* 0 -1e-12 \ 0.028634 0.028634 2158.9 2158.9 0 0 75396 4 /kinetics/dendgeom pink blue \ 153.22 6.529 0 simundump kpool /kinetics/chain/kinetics[38]/PKC/PKC-DAG-memb* 0 -1e-12 \ 0.0089225 0.0089225 672.72 672.72 0 0 75396 4 /kinetics/dendgeom yellow \ blue 154.17 5.5078 0 simundump kpool /kinetics/chain/kinetics[38]/PKC/PKC-Ca-DAG 0 -1e-12 \ 0.00089226 0.00089226 67.273 67.273 0 0 75396 4 /kinetics/dendgeom white \ blue 156.23 1.8026 0 simundump kreac /kinetics/chain/kinetics[38]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 152.99 -1.9902 0 simundump kpool /kinetics/chain/kinetics[38]/PKC/PKC-DAG 0 -1e-12 0.060193 \ 0.060193 4538.3 4538.3 0 0 75396 4 /kinetics/dendgeom white blue 155 \ -1.0857 0 simundump kpool /kinetics/chain/kinetics[38]/PKC/PKC-cytosolic 0 -1e-12 \ 0.8223 0.8223 61998 61998 0 0 75396 4 /kinetics/dendgeom white blue 149.87 \ 0.59711 0 simundump kpool /kinetics/chain/kinetics[38]/PKC/PKM-zeta 0 -1e-12 0.01007 \ 0.01007 759.21 759.21 0 0 75396 4 /kinetics/dendgeom cyan blue 153 11 0 simundump kpool /kinetics/chain/kinetics[38]/DAG 1 -1e-12 12.2 12.2 \ 9.1983e+05 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 160 -3 0 simundump kpool /kinetics/chain/kinetics[38]/PKC-active 1 -1e-12 0.047627 \ 0.047626 3590.8 3590.9 0 0 75396 4 /kinetics/dendgeom red black 156 9 0 simundump kenz /kinetics/chain/kinetics[38]/PKC-active/PKC-act-raf 1 \ 0.0011493 0.0011493 86.652 86.652 75396 1.3263e-05 16 4 0 0 "" red yellow \ "" 162 10 0 simundump kenz /kinetics/chain/kinetics[38]/PKC-active/PKC-inact-GAP 1 53.939 \ 53.939 6.778 6.778 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 160 13 0 simundump kenz /kinetics/chain/kinetics[38]/PKC-active/PKC-act-GEF 1 726.99 \ 726.99 91.354 91.354 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 165 20 0 simundump kpool /kinetics/chain/kinetics[38]/MAPK* 1 -1e-12 7.8539e-05 \ 7.8539e-05 5.9215 5.9215 0 0 75396 4 /kinetics/dendgeom orange yellow 169 1 \ 0 simundump kenz /kinetics/chain/kinetics[38]/MAPK*/MAPK*-feedback 1 3.6779e-08 \ 3.6779e-08 0.002773 0.002773 75396 2.5864e-05 40 10 0 0 "" red orange "" \ 166 10 0 simundump group /kinetics/chain/kinetics[38]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 171 11 0 simundump kpool /kinetics/chain/kinetics[38]/MAPK/craf-1 0 0 0.48263 0.48263 \ 36388 36388 0 0 75396 4 /kinetics/dendgeom pink brown 162 8 0 simundump kpool /kinetics/chain/kinetics[38]/MAPK/craf-1* 0 0 0.012007 \ 0.012007 905.28 905.28 0 0 75396 4 /kinetics/dendgeom pink brown 165 8 0 simundump kpool /kinetics/chain/kinetics[38]/MAPK/MAPKK 0 0 0.4946 0.4946 \ 37291 37291 0 0 75396 4 /kinetics/dendgeom pink brown 162 4 0 simundump kpool /kinetics/chain/kinetics[38]/MAPK/MAPK 0 -1e-12 3.5824 3.5824 \ 2.701e+05 2.701e+05 0 0 75396 4 /kinetics/dendgeom pink brown 162 1 0 simundump kpool /kinetics/chain/kinetics[38]/MAPK/craf-1** 1 0 9.6059e-07 \ 9.6059e-07 0.072425 0.072425 0 0 75396 4 /kinetics/dendgeom hotpink brown \ 168 8 0 simundump kpool /kinetics/chain/kinetics[38]/MAPK/MAPK-tyr 1 -1e-12 0.016774 \ 0.016774 1264.7 1264.7 0 0 75396 4 /kinetics/dendgeom orange brown 165 1 0 simundump kpool /kinetics/chain/kinetics[38]/MAPK/MAPKK* 0 0 8.2386e-06 \ 8.2386e-06 0.62116 0.62116 0 0 75396 4 /kinetics/dendgeom pink brown 169 4 \ 0 simundump kenz /kinetics/chain/kinetics[38]/MAPK/MAPKK*/MAPKKtyr 0 0.00063751 \ 0.00063751 48.066 48.066 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 164 3 \ 0 simundump kenz /kinetics/chain/kinetics[38]/MAPK/MAPKK*/MAPKKthr 1 2.985e-06 \ 2.985e-06 0.22506 0.22506 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 169 3 \ 0 simundump kpool /kinetics/chain/kinetics[38]/MAPK/MAPKK-ser 1 0 0.0020188 \ 0.0020188 152.21 152.21 0 0 75396 4 /kinetics/dendgeom pink brown 165 4 0 simundump kpool /kinetics/chain/kinetics[38]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 4 /kinetics/dendgeom 55 brown 161 6 0 simundump kenz /kinetics/chain/kinetics[38]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 164 6 0 simundump kenz /kinetics/chain/kinetics[38]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 167 6 0 simundump kpool /kinetics/chain/kinetics[38]/MAPK/Raf*-GTP-Ras 1 0 0.00082874 \ 0.00082874 62.484 62.484 0 0 75396 4 /kinetics/dendgeom red brown 161 5 0 simundump kenz /kinetics/chain/kinetics[38]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 1545.9 1545.9 194.26 194.26 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" \ 164 5 0 simundump kenz /kinetics/chain/kinetics[38]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 6.3096 6.3096 0.79287 0.79287 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" \ 167 5 0 simundump kpool /kinetics/chain/kinetics[38]/MKP-1 1 -1e-12 0.019951 0.019951 \ 1504.2 1504.2 0 0 75396 4 /kinetics/dendgeom hotpink black 161 2 0 simundump kenz /kinetics/chain/kinetics[38]/MKP-1/MKP1-tyr-deph 1 4.781e-05 \ 4.781e-05 3.6047 3.6047 75396 3.7895e-05 16 4 0 0 "" red hotpink "" 162 3 0 simundump kenz /kinetics/chain/kinetics[38]/MKP-1/MKP1-thr-deph 1 2.2386e-07 \ 2.2386e-07 0.016878 0.016878 75396 3.7895e-05 16 4 0 0 "" red hotpink "" \ 167 3 0 simundump kreac /kinetics/chain/kinetics[38]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 159 9 0 simundump kpool /kinetics/chain/kinetics[38]/PPhosphatase2A 1 -1e-12 0.9991 \ 0.9991 75328 75328 0 0 75396 4 /kinetics/dendgeom hotpink yellow 165 9 0 simundump kenz /kinetics/chain/kinetics[38]/PPhosphatase2A/craf-deph 1 \ 0.00076621 0.00076621 57.769 57.769 75396 2.5414e-05 24 6 0 0 "" red \ hotpink "" 164 10 0 simundump kenz /kinetics/chain/kinetics[38]/PPhosphatase2A/MAPKK-deph 1 \ 5.2573e-07 5.2573e-07 0.039638 0.039638 75396 2.5414e-05 24 6 0 0 "" red \ hotpink "" 167 7 0 simundump kenz /kinetics/chain/kinetics[38]/PPhosphatase2A/MAPKK-deph-ser 1 \ 0.00012882 0.00012882 9.7128 9.7128 75396 2.5414e-05 24 6 0 0 "" red \ hotpink "" 164 7 0 simundump kenz /kinetics/chain/kinetics[38]/PPhosphatase2A/craf**-deph 1 \ 0.036779 0.036779 0.0046216 0.0046216 0.12566 2.5414e-05 24 6 0 0 "" red \ hotpink "" 168 10 0 simundump group /kinetics/chain/kinetics[38]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 170.51 16.351 0 simundump kreac /kinetics/chain/kinetics[38]/Ras/dephosph-GEF 1 1 0 "" white \ blue 165.07 17.881 0 simundump kpool /kinetics/chain/kinetics[38]/Ras/inact-GEF 1 -1e-12 0.084803 \ 0.084803 6393.8 6393.8 0 0 75396 4 /kinetics/dendgeom hotpink blue 168.45 \ 18.352 0 simundump kenz /kinetics/chain/kinetics[38]/Ras/inact-GEF/basal_GEF_activity 0 \ 0.0040648 0.0040648 306.47 306.47 75396 1.313e-07 0.08 0.02 0 0 "" red \ hotpink "" 168 17 0 simundump kpool /kinetics/chain/kinetics[38]/Ras/GEF* 1 -1e-12 0.0048465 \ 0.0048465 365.41 365.41 0 0 75396 4 /kinetics/dendgeom hotpink blue 162.45 \ 17.246 0 simundump kenz /kinetics/chain/kinetics[38]/Ras/GEF*/GEF*-act-ras 1 0.0046465 \ 0.0046465 350.33 350.33 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" \ 163.09 16.086 0 simundump kpool /kinetics/chain/kinetics[38]/Ras/GTP-Ras 1 0 0.0034512 \ 0.0034512 260.21 260.21 0 0 75396 4 /kinetics/dendgeom orange blue 168.56 \ 13.084 0 simundump kpool /kinetics/chain/kinetics[38]/Ras/GDP-Ras 1 0 0.48419 0.48419 \ 36506 36506 0 0 75396 4 /kinetics/dendgeom pink blue 162.13 14.165 0 simundump kreac /kinetics/chain/kinetics[38]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 165.1 13.5 0 simundump kreac /kinetics/chain/kinetics[38]/Ras/dephosph-GAP 1 0.1 0 "" \ white blue 160.02 15.524 0 simundump kpool /kinetics/chain/kinetics[38]/Ras/GAP* 1 -1e-12 0.0035959 \ 0.0035959 271.12 271.12 0 0 75396 4 /kinetics/dendgeom red blue 157.35 \ 14.349 0 simundump kpool /kinetics/chain/kinetics[38]/Ras/GAP 1 -1e-12 0.0062918 \ 0.0062918 474.38 474.38 0 0 75396 4 /kinetics/dendgeom red blue 162.65 \ 12.338 0 simundump kenz /kinetics/chain/kinetics[38]/Ras/GAP/GAP-inact-ras 1 \ 2.1491e-05 2.1491e-05 1.6203 1.6203 75396 0.00065634 40 10 0 0 "" red red \ "" 165.01 12.403 0 simundump kreac /kinetics/chain/kinetics[38]/Ras/CaM-bind-GEF 1 0.0026526 1 \ "" white blue 158.49 21.679 0 simundump kpool /kinetics/chain/kinetics[38]/Ras/CaM-GEF 1 -1e-12 0.00021398 \ 0.00021398 16.133 16.133 0 0 75396 4 /kinetics/dendgeom pink blue 161.35 \ 19.58 0 simundump kenz /kinetics/chain/kinetics[38]/Ras/CaM-GEF/CaM-GEF-act-ras 1 \ 0.00020513 0.00020513 15.466 15.466 75396 2.6261e-05 0.8 0.2 0 0 "" red \ pink "" 161.02 18.657 0 simundump group /kinetics/chain/kinetics[38]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 146 21 0 simundump kpool /kinetics/chain/kinetics[38]/CaM/CaM 1 -1e-12 18.403 18.403 \ 1.3875e+06 1.3875e+06 0 0 75396 4 /kinetics/dendgeom pink blue 143 30 0 simundump kreac /kinetics/chain/kinetics[38]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 145.6 23.26 0 simundump kpool /kinetics/chain/kinetics[38]/CaM/CaM-Ca3 1 -1e-12 0.0033914 \ 0.0033914 255.7 255.7 0 0 75396 4 /kinetics/dendgeom hotpink blue 149.49 \ 24.397 0 simundump kpool /kinetics/chain/kinetics[38]/CaM/CaM-Ca4 1 -1e-12 1.2616e-05 \ 1.2616e-05 0.95122 0.95122 0 0 75396 4 /kinetics/dendgeom blue blue 154 24 \ 0 simundump kreac /kinetics/chain/kinetics[38]/CaM/CaM-bind-Ca 1 0.00011254 \ 8.4853 "" white blue 146 30 0 simundump kpool /kinetics/chain/kinetics[38]/CaM/CaM-Ca2 1 -1e-12 0.11776 \ 0.11776 8878.5 8878.5 0 0 75396 4 /kinetics/dendgeom pink blue 151 27.258 0 simundump kreac /kinetics/chain/kinetics[38]/CaM/CaM-Ca2-bind-Ca 1 4.7748e-05 \ 10 "" white blue 147.16 26.225 0 simundump kreac /kinetics/chain/kinetics[38]/CaM/CaM-Ca-bind-Ca 1 0.00011254 \ 8.4853 "" white blue 152 30 0 simundump kpool /kinetics/chain/kinetics[38]/CaM/CaM-Ca 1 -1e-12 1.472 1.472 \ 1.1098e+05 1.1098e+05 0 0 75396 4 /kinetics/dendgeom pink blue 149 31 0 simundump kpool /kinetics/chain/kinetics[38]/Ca 1 -1e-12 0.08 0.08 6031.7 \ 6031.7 0 0 75396 4 /kinetics/dendgeom red black 138 23 0 simundump kreac /kinetics/chain/kinetics[38]/Ras-act-unphosph-raf 0 0 0 "" \ white black 160 8 0 simundump group /kinetics/chain/kinetics[38]/PKM 0 25 black x 0 0 "" PKM \ defaultfile.g 0 5dc016e940e88c1cc7928f4e096ff523 0 149 19 0 simundump kpool /kinetics/chain/kinetics[38]/PKM/Ca_detector 0 -1e-12 0.99987 \ 0.99987 75386 75386 0 0 75396 4 /kinetics/dendgeom 7 25 145 17 0 simundump kpool /kinetics/chain/kinetics[38]/PKM/PKM_synthesis 0 -1e-12 \ 0.0010085 0.0010085 76.04 76.04 0 0 75396 4 /kinetics/dendgeom 8 25 145 9 0 simundump kenz /kinetics/chain/kinetics[38]/PKM/PKM_synthesis/kenz 0 \ 0.00010086 0.00010086 7.6041 7.6041 75396 3.3159e-07 0.2 0.05 0 0 "" red 8 \ "" 146 10 0 simundump kpool /kinetics/chain/kinetics[38]/PKM/AA_pool 0 -1e-12 1 1 75396 \ 75396 0 0 75396 4 /kinetics/dendgeom 9 25 149 12 0 simundump kreac /kinetics/chain/kinetics[38]/PKM/PKM_degradation 0 0.0005 0 \ "" white 25 148 7 0 simundump kpool /kinetics/chain/kinetics[38]/PKM/degraded_PKM 0 -1e-12 0 0 0 \ 0 0 0 75396 4 /kinetics/dendgeom 7 25 144 5 0 simundump kpool /kinetics/chain/kinetics[38]/PKM/Ca.detector_complex 0 -1e-12 \ 0.00012615 0.00012615 9.5109 9.5109 0 0 75396 4 /kinetics/dendgeom 7 25 144 \ 14 0 simundump kenz /kinetics/chain/kinetics[38]/PKM/Ca.detector_complex/kenz 0 \ 5.0428e-06 5.0428e-06 0.38021 0.38021 75396 2.6526e-06 0.8 0.2 0 0 "" red 7 \ "" 144 13 0 simundump kpool /kinetics/chain/kinetics[38]/PKM/PKM_activator 0 -1e-12 \ 0.19988 0.19988 15070 15070 0 0 75396 4 /kinetics/dendgeom 6 25 141 12 0 simundump kreac /kinetics/chain/kinetics[38]/PKM/turn_off_activator 0 0.001 0 \ "" white 25 139 9 0 simundump kreac /kinetics/chain/kinetics[38]/PKM/trigger_PKM 0 0.00013263 1 \ "" white 25 139 16 0 simundump kpool /kinetics/chain/kinetics[38]/Ca_input 0 0 0.08 0.08 6031.7 \ 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 138 30 0 simundump kreac /kinetics/chain/kinetics[38]/Ca_diff 0 5 5 "" white black 138 \ 26 0 simundump doqcsinfo /kinetics/doqcsinfo 0 Ajay_Bhalla_2007_ReacDiff2.g \ Ajay_Bhalla_2007_ReacDiff2 network "Upinder S. Bhalla, NCBS" \ "Upinder S. Bhalla, NCBS" "citation here" Rat "Hippocampal CA1" Dendrite \ "Semi-Quantitative match to experiments" \ "Ajay_Bhalla_rec_diff2 (Under Review)" "Exact GENESIS implementation" \ "Replicates original data " 0 0 0 simundump xgraph /graphs/conc1 0 0 5000 0.00087037 0.10434 0 simundump xgraph /graphs/conc2 0 0 5000 0 0.088747 0 simundump xgraph /moregraphs/conc3 0 0 5000 0 1 0 simundump xgraph /moregraphs/conc4 0 0 5000 0 1 0 simundump xcoredraw /edit/draw 0 -20 173 -5 36 simundump xtree /edit/draw/tree 0 \ /kinetics/#[],/kinetics/#[]/#[],/kinetics/#[]/#[]/#[][TYPE!=proto],/kinetics/#[]/#[]/#[][TYPE!=linkinfo]/##[] \ "edit_elm.D ; drag_from_edit.w " auto 0.6 simundump xtext /file/notes 0 1 xtextload /file/notes \ "27 Feb 2006. Updated version of pkm_mapk1.g Set up diffusion constants," \ "or more accurately, decided which molecules should not diffuse." \ "2 March 2006. Based on pkm_mapk2.g, just added Ca_input and" \ "Ca_diff to set up the propagation model with slightly smoother" \ "Ca transients. This matches the PKC-MAPK bis model." \ "Saved as pkm_mapk3.g" \ "13 Mar 2006. Speeded up rates of trigger_PKM 10x from the " \ "pkm_mapk3.g model. Also speeded up Ca_diff rates from tau of 0.25" \ "to tau of 0.1" \ "Saved as pkm_mapk12.g" \ "13 Mar 2006. Same as previous, except the trigger_PKM Kd is" \ "now 1.4142. Saved as" \ "pkm_mapk13.g" \ "17 Marh 2006. Changed Ca trigger for PKM Synthesis to depend on" \ "Ca4.CaM. Also scaled up CaM-GEF-act-ras kcat from 0.02 to 0.4." \ "Saved as pkm_mapk20.g" \ "17 March. Based on pkm_mapk20.g Changed CaM-GEF-act-ras kcat " \ "to 0.2." \ "Saved as pkm_mapk21.g" \ "" \ "19 May 2006. Based on pkm_mapk21.g. Split up initial step of" \ "2Ca binding to CaM into two reactions, in each of which 1 Ca" \ "binds. Improves numerical stability but overall equil should" \ "not change. " \ "Saved as pkm_mapk22.g" \ "19 Sep 2006. Same as above, except that the initial conditions" \ "have been settled." \ "21 Sep 2006. Diffusive version for transport. The end compartments" \ "have been buffered, and the kf for the flux reactions called" \ "diff have been converted to 0.101 for a net transport rate" \ "of 1 micron/sec. Saved as" \ "pkm_mapk22_transp_endbuf_D1e-13.g" \ "" \ "" addmsg /kinetics/PKC/PKC-act-by-Ca /kinetics/PKC/PKC-Ca REAC B A addmsg /kinetics/PKC/PKC-act-by-DAG /kinetics/PKC/PKC-Ca REAC A B addmsg /kinetics/PKC/PKC-Ca-to-memb /kinetics/PKC/PKC-Ca REAC A B addmsg /kinetics/PKC/PKC-Ca/diff /kinetics/PKC/PKC-Ca REAC A B addmsg /kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/PKC/PKC-cytosolic /kinetics/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/Ca /kinetics/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/DAG /kinetics/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/PKC/PKC-Ca-DAG /kinetics/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/PKC/PKC-Ca-memb* /kinetics/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/PKC/PKC-Ca-DAG /kinetics/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/PKC/PKC-DAG-memb* /kinetics/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/PKC/PKC-Ca-to-memb /kinetics/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/PKC/PKC-Ca-memb*/diff /kinetics/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/PKC/PKC-Ca-memb* /kinetics/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-memb* /kinetics/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/PKC/PKC-DAG-to-memb /kinetics/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/PKC/PKC-DAG-memb*/diff /kinetics/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/PKC/PKC-DAG-memb* /kinetics/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-memb* /kinetics/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/PKC/PKC-act-by-DAG /kinetics/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/PKC/PKC-DAG-to-memb /kinetics/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/PKC/PKC-Ca-DAG/diff /kinetics/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/PKC/PKC-Ca-DAG /kinetics/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-DAG /kinetics/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/PKC/PKC-cytosolic /kinetics/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/DAG /kinetics/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/PKC/PKC-DAG /kinetics/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/PKC/PKC-n-DAG /kinetics/PKC/PKC-DAG REAC B A addmsg /kinetics/PKC/PKC-DAG/diff /kinetics/PKC/PKC-DAG REAC A B addmsg /kinetics/PKC/PKC-DAG /kinetics/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-DAG /kinetics/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/PKC/PKC-act-by-Ca /kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/PKC/PKC-n-DAG /kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/PKC/PKC-cytosolic/diff /kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/PKC/PKC-cytosolic /kinetics/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-cytosolic /kinetics/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/PKM/PKM_synthesis/kenz /kinetics/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/PKM/PKM_degradation /kinetics/PKC/PKM-zeta REAC A B addmsg /kinetics/PKC/PKM-zeta/diff /kinetics/PKC/PKM-zeta REAC A B addmsg /kinetics/PKC/PKM-zeta /kinetics/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKM-zeta /kinetics/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/PKC/PKC-act-by-DAG /kinetics/DAG REAC A B addmsg /kinetics/PKC/PKC-n-DAG /kinetics/DAG REAC A B addmsg /kinetics/PKC/PKC-Ca-memb* /kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/PKC/PKC-DAG-memb* /kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/PKC-active/PKC-act-raf /kinetics/PKC-active REAC eA B addmsg /kinetics/PKC-active/PKC-inact-GAP /kinetics/PKC-active REAC eA B addmsg /kinetics/PKC-active/PKC-act-GEF /kinetics/PKC-active REAC eA B addmsg /kinetics/PKC/PKM-zeta /kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/PKC-active /kinetics/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/MAPK/craf-1 /kinetics/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/PKC-active /kinetics/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/Ras/GAP /kinetics/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/PKC-active /kinetics/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/Ras/inact-GEF /kinetics/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/MAPK*/MAPK*-feedback /kinetics/MAPK* REAC eA B addmsg /kinetics/MAPK/MAPKK*/MAPKKthr /kinetics/MAPK* MM_PRD pA addmsg /kinetics/MKP-1/MKP1-thr-deph /kinetics/MAPK* REAC sA B addmsg /kinetics/MAPK*/diff /kinetics/MAPK* REAC A B addmsg /kinetics/MAPK* /kinetics/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/MAPK/craf-1* /kinetics/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/MAPK* /kinetics/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK* /kinetics/MAPK*/diff PRODUCT n addmsg /kinetics/PKC-active/PKC-act-raf /kinetics/MAPK/craf-1 REAC sA B addmsg /kinetics/PPhosphatase2A/craf-deph /kinetics/MAPK/craf-1 MM_PRD pA addmsg /kinetics/Ras-act-unphosph-raf /kinetics/MAPK/craf-1 REAC A B addmsg /kinetics/MAPK/craf-1/diff /kinetics/MAPK/craf-1 REAC A B addmsg /kinetics/MAPK/craf-1 /kinetics/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/craf-1 /kinetics/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/PKC-active/PKC-act-raf /kinetics/MAPK/craf-1* MM_PRD pA addmsg /kinetics/MAPK*/MAPK*-feedback /kinetics/MAPK/craf-1* REAC sA B addmsg /kinetics/PPhosphatase2A/craf-deph /kinetics/MAPK/craf-1* REAC sA B addmsg /kinetics/PPhosphatase2A/craf**-deph /kinetics/MAPK/craf-1* MM_PRD pA addmsg /kinetics/Ras-act-craf /kinetics/MAPK/craf-1* REAC A B addmsg /kinetics/MAPK/craf-1*/diff /kinetics/MAPK/craf-1* REAC A B addmsg /kinetics/MAPK/craf-1* /kinetics/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/craf-1* /kinetics/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/PPhosphatase2A/MAPKK-deph-ser /kinetics/MAPK/MAPKK MM_PRD pA addmsg /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/MAPK/MAPKK REAC sA B addmsg /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/MAPK/MAPKK REAC sA B addmsg /kinetics/MAPK/MAPKK/diff /kinetics/MAPK/MAPKK REAC A B addmsg /kinetics/MAPK/MAPKK /kinetics/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/MAPKK /kinetics/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/MAPK/MAPKK*/MAPKKtyr /kinetics/MAPK/MAPK REAC sA B addmsg /kinetics/MKP-1/MKP1-tyr-deph /kinetics/MAPK/MAPK MM_PRD pA addmsg /kinetics/MAPK/MAPK/diff /kinetics/MAPK/MAPK REAC A B addmsg /kinetics/MAPK/MAPK /kinetics/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/MAPK /kinetics/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/MAPK*/MAPK*-feedback /kinetics/MAPK/craf-1** MM_PRD pA addmsg /kinetics/PPhosphatase2A/craf**-deph /kinetics/MAPK/craf-1** REAC sA B addmsg /kinetics/MAPK/craf-1**/diff /kinetics/MAPK/craf-1** REAC A B addmsg /kinetics/MAPK/craf-1** /kinetics/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/craf-1** /kinetics/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/MAPK/MAPKK*/MAPKKtyr /kinetics/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/MAPK/MAPKK*/MAPKKthr /kinetics/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/MKP-1/MKP1-tyr-deph /kinetics/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/MKP-1/MKP1-thr-deph /kinetics/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/MAPK/MAPK-tyr/diff /kinetics/MAPK/MAPK-tyr REAC A B addmsg /kinetics/MAPK/MAPK-tyr /kinetics/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/MAPK-tyr /kinetics/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/MAPK/MAPKK*/MAPKKtyr /kinetics/MAPK/MAPKK* REAC eA B addmsg /kinetics/MAPK/MAPKK*/MAPKKthr /kinetics/MAPK/MAPKK* REAC eA B addmsg /kinetics/PPhosphatase2A/MAPKK-deph /kinetics/MAPK/MAPKK* REAC sA B addmsg /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/MAPK/MAPKK*/diff /kinetics/MAPK/MAPKK* REAC A B addmsg /kinetics/MAPK/MAPKK* /kinetics/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/MAPK/MAPK /kinetics/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/MAPK/MAPKK* /kinetics/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/MAPK/MAPK-tyr /kinetics/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/MAPK/MAPKK* /kinetics/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/MAPKK* /kinetics/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/PPhosphatase2A/MAPKK-deph /kinetics/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/PPhosphatase2A/MAPKK-deph-ser /kinetics/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/MAPK/MAPKK-ser/diff /kinetics/MAPK/MAPKK-ser REAC A B addmsg /kinetics/MAPK/MAPKK-ser /kinetics/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/MAPKK-ser /kinetics/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/Ras-act-unphosph-raf /kinetics/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/MAPK/Raf-GTP-Ras/diff /kinetics/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/MAPK/Raf-GTP-Ras /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/MAPK/MAPKK /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/MAPK/Raf-GTP-Ras /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/MAPK/MAPKK-ser /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/MAPK/Raf-GTP-Ras /kinetics/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras /kinetics/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/Ras-act-craf /kinetics/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/MAPK/Raf*-GTP-Ras/diff /kinetics/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/MAPK/Raf*-GTP-Ras /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/MAPK/MAPKK /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/MAPK/Raf*-GTP-Ras /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/MAPK/MAPKK-ser /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/MAPK/Raf*-GTP-Ras /kinetics/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras /kinetics/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/MKP-1/MKP1-tyr-deph /kinetics/MKP-1 REAC eA B addmsg /kinetics/MKP-1/MKP1-thr-deph /kinetics/MKP-1 REAC eA B addmsg /kinetics/MKP-1/diff /kinetics/MKP-1 REAC A B addmsg /kinetics/MKP-1 /kinetics/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/MAPK/MAPK-tyr /kinetics/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/MKP-1 /kinetics/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/MAPK* /kinetics/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/MKP-1 /kinetics/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/MKP-1 /kinetics/MKP-1/diff PRODUCT n addmsg /kinetics/MAPK/craf-1* /kinetics/Ras-act-craf SUBSTRATE n addmsg /kinetics/Ras/GTP-Ras /kinetics/Ras-act-craf SUBSTRATE n addmsg /kinetics/MAPK/Raf*-GTP-Ras /kinetics/Ras-act-craf PRODUCT n addmsg /kinetics/PPhosphatase2A/craf-deph /kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/PPhosphatase2A/MAPKK-deph /kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/PPhosphatase2A/MAPKK-deph-ser /kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/PPhosphatase2A/craf**-deph /kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/PPhosphatase2A/diff /kinetics/PPhosphatase2A REAC A B addmsg /kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/MAPK/craf-1* /kinetics/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/MAPK/MAPKK* /kinetics/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/MAPK/MAPKK-ser /kinetics/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/MAPK/craf-1** /kinetics/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/Ras/GEF* /kinetics/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/Ras/inact-GEF /kinetics/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/PKC-active/PKC-act-GEF /kinetics/Ras/inact-GEF REAC sA B addmsg /kinetics/Ras/dephosph-GEF /kinetics/Ras/inact-GEF REAC B A addmsg /kinetics/Ras/CaM-bind-GEF /kinetics/Ras/inact-GEF REAC A B addmsg /kinetics/Ras/inact-GEF/basal_GEF_activity /kinetics/Ras/inact-GEF REAC eA B addmsg /kinetics/Ras/inact-GEF/diff /kinetics/Ras/inact-GEF REAC A B addmsg /kinetics/Ras/inact-GEF /kinetics/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/Ras/GDP-Ras /kinetics/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/Ras/inact-GEF /kinetics/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/inact-GEF /kinetics/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/PKC-active/PKC-act-GEF /kinetics/Ras/GEF* MM_PRD pA addmsg /kinetics/Ras/dephosph-GEF /kinetics/Ras/GEF* REAC A B addmsg /kinetics/Ras/GEF*/GEF*-act-ras /kinetics/Ras/GEF* REAC eA B addmsg /kinetics/Ras/GEF*/diff /kinetics/Ras/GEF* REAC A B addmsg /kinetics/Ras/GEF* /kinetics/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/Ras/GDP-Ras /kinetics/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/Ras/GEF* /kinetics/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/GEF* /kinetics/Ras/GEF*/diff PRODUCT n addmsg /kinetics/Ras/GAP/GAP-inact-ras /kinetics/Ras/GTP-Ras REAC sA B addmsg /kinetics/Ras/Ras-intrinsic-GTPase /kinetics/Ras/GTP-Ras REAC A B addmsg /kinetics/Ras/GEF*/GEF*-act-ras /kinetics/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/Ras-act-craf /kinetics/Ras/GTP-Ras REAC A B addmsg /kinetics/Ras-act-unphosph-raf /kinetics/Ras/GTP-Ras REAC A B addmsg /kinetics/Ras/inact-GEF/basal_GEF_activity /kinetics/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/Ras/GTP-Ras/diff /kinetics/Ras/GTP-Ras REAC A B addmsg /kinetics/Ras/GTP-Ras /kinetics/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/GTP-Ras /kinetics/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/Ras/GAP/GAP-inact-ras /kinetics/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/Ras/Ras-intrinsic-GTPase /kinetics/Ras/GDP-Ras REAC B A addmsg /kinetics/Ras/GEF*/GEF*-act-ras /kinetics/Ras/GDP-Ras REAC sA B addmsg /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/Ras/GDP-Ras REAC sA B addmsg /kinetics/Ras/inact-GEF/basal_GEF_activity /kinetics/Ras/GDP-Ras REAC sA B addmsg /kinetics/Ras/GDP-Ras/diff /kinetics/Ras/GDP-Ras REAC A B addmsg /kinetics/Ras/GDP-Ras /kinetics/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/GDP-Ras /kinetics/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/Ras/GTP-Ras /kinetics/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/Ras/GDP-Ras /kinetics/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/Ras/GAP* /kinetics/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/Ras/GAP /kinetics/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/PKC-active/PKC-inact-GAP /kinetics/Ras/GAP* MM_PRD pA addmsg /kinetics/Ras/dephosph-GAP /kinetics/Ras/GAP* REAC A B addmsg /kinetics/Ras/GAP*/diff /kinetics/Ras/GAP* REAC A B addmsg /kinetics/Ras/GAP* /kinetics/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/GAP* /kinetics/Ras/GAP*/diff PRODUCT n addmsg /kinetics/Ras/GAP/GAP-inact-ras /kinetics/Ras/GAP REAC eA B addmsg /kinetics/PKC-active/PKC-inact-GAP /kinetics/Ras/GAP REAC sA B addmsg /kinetics/Ras/dephosph-GAP /kinetics/Ras/GAP REAC B A addmsg /kinetics/Ras/GAP/diff /kinetics/Ras/GAP REAC A B addmsg /kinetics/Ras/GAP /kinetics/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/Ras/GTP-Ras /kinetics/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/Ras/GAP /kinetics/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/GAP /kinetics/Ras/GAP/diff PRODUCT n addmsg /kinetics/Ras/inact-GEF /kinetics/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/Ras/CaM-GEF /kinetics/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/CaM/CaM-Ca4 /kinetics/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/Ras/CaM-bind-GEF /kinetics/Ras/CaM-GEF REAC B A addmsg /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/Ras/CaM-GEF REAC eA B addmsg /kinetics/Ras/CaM-GEF/diff /kinetics/Ras/CaM-GEF REAC A B addmsg /kinetics/Ras/CaM-GEF /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/Ras/GDP-Ras /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/Ras/CaM-GEF /kinetics/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/CaM-GEF /kinetics/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/CaM/CaM-bind-Ca /kinetics/CaM/CaM REAC A B addmsg /kinetics/CaM/CaM/diff /kinetics/CaM/CaM REAC A B addmsg /kinetics/CaM/CaM /kinetics/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM /kinetics/CaM/CaM/diff PRODUCT n addmsg /kinetics/CaM/CaM-Ca3 /kinetics/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/Ca /kinetics/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/CaM/CaM-Ca4 /kinetics/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/CaM/CaM-Ca2-bind-Ca /kinetics/CaM/CaM-Ca3 REAC B A addmsg /kinetics/CaM/CaM-Ca3-bind-Ca /kinetics/CaM/CaM-Ca3 REAC A B addmsg /kinetics/CaM/CaM-Ca3/diff /kinetics/CaM/CaM-Ca3 REAC A B addmsg /kinetics/CaM/CaM-Ca3 /kinetics/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca3 /kinetics/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/Ras/CaM-bind-GEF /kinetics/CaM/CaM-Ca4 REAC A B addmsg /kinetics/CaM/CaM-Ca3-bind-Ca /kinetics/CaM/CaM-Ca4 REAC B A addmsg /kinetics/PKM/trigger_PKM /kinetics/CaM/CaM-Ca4 REAC A B addmsg /kinetics/CaM/CaM-Ca4/diff /kinetics/CaM/CaM-Ca4 REAC A B addmsg /kinetics/CaM/CaM-Ca4 /kinetics/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca4 /kinetics/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/CaM/CaM /kinetics/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/Ca /kinetics/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/CaM/CaM-Ca /kinetics/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/CaM/CaM-Ca2-bind-Ca /kinetics/CaM/CaM-Ca2 REAC A B addmsg /kinetics/CaM/CaM-Ca-bind-Ca /kinetics/CaM/CaM-Ca2 REAC B A addmsg /kinetics/CaM/CaM-Ca2/diff /kinetics/CaM/CaM-Ca2 REAC A B addmsg /kinetics/CaM/CaM-Ca2 /kinetics/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca2 /kinetics/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/CaM/CaM-Ca2 /kinetics/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/Ca /kinetics/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/CaM/CaM-Ca3 /kinetics/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/CaM/CaM-Ca /kinetics/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/Ca /kinetics/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/CaM/CaM-Ca2 /kinetics/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/CaM/CaM-bind-Ca /kinetics/CaM/CaM-Ca REAC B A addmsg /kinetics/CaM/CaM-Ca-bind-Ca /kinetics/CaM/CaM-Ca REAC A B addmsg /kinetics/CaM/CaM-Ca/diff /kinetics/CaM/CaM-Ca REAC A B addmsg /kinetics/CaM/CaM-Ca /kinetics/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca /kinetics/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/PKC/PKC-act-by-Ca /kinetics/Ca REAC A B addmsg /kinetics/CaM/CaM-bind-Ca /kinetics/Ca REAC A B addmsg /kinetics/CaM/CaM-Ca2-bind-Ca /kinetics/Ca REAC A B addmsg /kinetics/CaM/CaM-Ca3-bind-Ca /kinetics/Ca REAC A B addmsg /kinetics/Ca_diff /kinetics/Ca REAC B A addmsg /kinetics/CaM/CaM-Ca-bind-Ca /kinetics/Ca REAC A B addmsg /kinetics/Ca/diff /kinetics/Ca REAC A B addmsg /kinetics/Ca /kinetics/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/Ca /kinetics/Ca/diff PRODUCT n addmsg /kinetics/MAPK/craf-1 /kinetics/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/MAPK/Raf-GTP-Ras /kinetics/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/Ras/GTP-Ras /kinetics/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/PKM/trigger_PKM /kinetics/PKM/Ca_detector REAC A B addmsg /kinetics/PKM/Ca_detector/diff /kinetics/PKM/Ca_detector REAC A B addmsg /kinetics/PKM/Ca_detector /kinetics/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKM/Ca_detector /kinetics/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/PKM/PKM_synthesis/kenz /kinetics/PKM/PKM_synthesis REAC eA B addmsg /kinetics/PKM/Ca.detector_complex/kenz /kinetics/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/PKM/turn_off_activator /kinetics/PKM/PKM_synthesis REAC A B addmsg /kinetics/PKM/PKM_synthesis/diff /kinetics/PKM/PKM_synthesis REAC A B addmsg /kinetics/PKM/PKM_synthesis /kinetics/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/PKM/AA_pool /kinetics/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/PKM/PKM_synthesis /kinetics/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKM/PKM_synthesis /kinetics/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/PKM/PKM_synthesis/kenz /kinetics/PKM/AA_pool REAC sA B addmsg /kinetics/PKC/PKM-zeta /kinetics/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/PKM/degraded_PKM /kinetics/PKM/PKM_degradation PRODUCT n addmsg /kinetics/PKM/PKM_degradation /kinetics/PKM/degraded_PKM REAC B A addmsg /kinetics/PKM/Ca.detector_complex/kenz /kinetics/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/PKM/trigger_PKM /kinetics/PKM/Ca.detector_complex REAC B A addmsg /kinetics/PKM/Ca.detector_complex/diff /kinetics/PKM/Ca.detector_complex REAC A B addmsg /kinetics/PKM/Ca.detector_complex /kinetics/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/PKM/PKM_activator /kinetics/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/PKM/Ca.detector_complex /kinetics/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKM/Ca.detector_complex /kinetics/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/PKM/Ca.detector_complex/kenz /kinetics/PKM/PKM_activator REAC sA B addmsg /kinetics/PKM/turn_off_activator /kinetics/PKM/PKM_activator REAC B A addmsg /kinetics/PKM/PKM_activator/diff /kinetics/PKM/PKM_activator REAC A B addmsg /kinetics/PKM/PKM_activator /kinetics/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKM/PKM_activator /kinetics/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/PKM/PKM_synthesis /kinetics/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/PKM/PKM_activator /kinetics/PKM/turn_off_activator PRODUCT n addmsg /kinetics/PKM/Ca_detector /kinetics/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/PKM/Ca.detector_complex /kinetics/PKM/trigger_PKM PRODUCT n addmsg /kinetics/CaM/CaM-Ca4 /kinetics/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/Ca_diff /kinetics/Ca_input REAC A B addmsg /kinetics/Ca_input /kinetics/Ca_diff SUBSTRATE n addmsg /kinetics/Ca /kinetics/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-act-by-Ca /kinetics/chain/kinetics/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-act-by-DAG /kinetics/chain/kinetics/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-Ca/diff /kinetics/chain/kinetics/PKC/PKC-Ca REAC A B addmsg /kinetics/PKC/PKC-Ca/diff /kinetics/chain/kinetics/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-Ca /kinetics/chain/kinetics/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca /kinetics/chain/kinetics/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca /kinetics/chain/kinetics/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-cytosolic /kinetics/chain/kinetics/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics/Ca /kinetics/chain/kinetics/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca /kinetics/chain/kinetics/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-DAG /kinetics/chain/kinetics/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics/DAG /kinetics/chain/kinetics/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca /kinetics/chain/kinetics/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-memb* /kinetics/chain/kinetics/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-memb* /kinetics/chain/kinetics/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-DAG /kinetics/chain/kinetics/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-memb* /kinetics/chain/kinetics/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-memb* /kinetics/chain/kinetics/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-act-by-DAG /kinetics/chain/kinetics/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-DAG /kinetics/chain/kinetics/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-DAG /kinetics/chain/kinetics/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-cytosolic /kinetics/chain/kinetics/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics/DAG /kinetics/chain/kinetics/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-n-DAG /kinetics/chain/kinetics/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-DAG/diff /kinetics/chain/kinetics/PKC/PKC-DAG REAC A B addmsg /kinetics/PKC/PKC-DAG/diff /kinetics/chain/kinetics/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-DAG /kinetics/chain/kinetics/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG /kinetics/chain/kinetics/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-act-by-Ca /kinetics/chain/kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-n-DAG /kinetics/chain/kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-cytosolic /kinetics/chain/kinetics/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic /kinetics/chain/kinetics/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics/PKM/PKM_degradation /kinetics/chain/kinetics/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics/PKC/PKM-zeta/diff /kinetics/chain/kinetics/PKC/PKM-zeta REAC A B addmsg /kinetics/PKC/PKM-zeta/diff /kinetics/chain/kinetics/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics/PKC/PKM-zeta /kinetics/chain/kinetics/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKM-zeta /kinetics/chain/kinetics/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-act-by-DAG /kinetics/chain/kinetics/DAG REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-n-DAG /kinetics/chain/kinetics/DAG REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-memb* /kinetics/chain/kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-memb* /kinetics/chain/kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics/PKC/PKM-zeta /kinetics/chain/kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics/PKC-active/PKC-act-raf /kinetics/chain/kinetics/PKC-active REAC eA B addmsg /kinetics/chain/kinetics/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics/PKC-active REAC eA B addmsg /kinetics/chain/kinetics/PKC-active/PKC-act-GEF /kinetics/chain/kinetics/PKC-active REAC eA B addmsg /kinetics/chain/kinetics/PKC-active /kinetics/chain/kinetics/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics/MAPK/craf-1 /kinetics/chain/kinetics/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC-active /kinetics/chain/kinetics/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics/Ras/GAP /kinetics/chain/kinetics/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC-active /kinetics/chain/kinetics/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics/Ras/inact-GEF /kinetics/chain/kinetics/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK*/MAPK*-feedback /kinetics/chain/kinetics/MAPK* REAC eA B addmsg /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics/MAPK* REAC sA B addmsg /kinetics/chain/kinetics/MAPK*/diff /kinetics/chain/kinetics/MAPK* REAC A B addmsg /kinetics/MAPK*/diff /kinetics/chain/kinetics/MAPK* REAC B A addmsg /kinetics/chain/kinetics/MAPK* /kinetics/chain/kinetics/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics/MAPK/craf-1* /kinetics/chain/kinetics/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK* /kinetics/chain/kinetics/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK* /kinetics/chain/kinetics/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC-active/PKC-act-raf /kinetics/chain/kinetics/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics/PPhosphatase2A/craf-deph /kinetics/chain/kinetics/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics/Ras-act-unphosph-raf /kinetics/chain/kinetics/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics/MAPK/craf-1/diff /kinetics/chain/kinetics/MAPK/craf-1 REAC A B addmsg /kinetics/MAPK/craf-1/diff /kinetics/chain/kinetics/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics/MAPK/craf-1 /kinetics/chain/kinetics/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1 /kinetics/chain/kinetics/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC-active/PKC-act-raf /kinetics/chain/kinetics/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK*/MAPK*-feedback /kinetics/chain/kinetics/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics/Ras-act-craf /kinetics/chain/kinetics/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics/PPhosphatase2A/craf-deph /kinetics/chain/kinetics/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/craf-1*/diff /kinetics/chain/kinetics/MAPK/craf-1* REAC A B addmsg /kinetics/MAPK/craf-1*/diff /kinetics/chain/kinetics/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics/MAPK/craf-1* /kinetics/chain/kinetics/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1* /kinetics/chain/kinetics/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/MAPKK/diff /kinetics/chain/kinetics/MAPK/MAPKK REAC A B addmsg /kinetics/MAPK/MAPKK/diff /kinetics/chain/kinetics/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics/MAPK/MAPKK /kinetics/chain/kinetics/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK /kinetics/chain/kinetics/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/MAPK/diff /kinetics/chain/kinetics/MAPK/MAPK REAC A B addmsg /kinetics/MAPK/MAPK/diff /kinetics/chain/kinetics/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics/MAPK/MAPK /kinetics/chain/kinetics/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK /kinetics/chain/kinetics/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics/MAPK*/MAPK*-feedback /kinetics/chain/kinetics/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics/MAPK/craf-1**/diff /kinetics/chain/kinetics/MAPK/craf-1** REAC A B addmsg /kinetics/MAPK/craf-1**/diff /kinetics/chain/kinetics/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics/MAPK/craf-1** /kinetics/chain/kinetics/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1** /kinetics/chain/kinetics/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics/MAPK/MAPK-tyr REAC A B addmsg /kinetics/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics/MAPK/MAPK-tyr /kinetics/chain/kinetics/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr /kinetics/chain/kinetics/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics/MAPK/MAPKK*/diff /kinetics/chain/kinetics/MAPK/MAPKK* REAC A B addmsg /kinetics/MAPK/MAPKK*/diff /kinetics/chain/kinetics/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics/MAPK/MAPK /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/MAPKK* /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics/MAPK/MAPK-tyr /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/MAPKK* /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics/MAPK/MAPKK* /kinetics/chain/kinetics/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK* /kinetics/chain/kinetics/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics/MAPK/MAPKK-ser REAC A B addmsg /kinetics/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics/MAPK/MAPKK-ser /kinetics/chain/kinetics/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser /kinetics/chain/kinetics/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics/Ras-act-unphosph-raf /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics/MAPK/MAPKK /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics/MAPK/MAPKK-ser /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics/Ras-act-craf /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics/MAPK/MAPKK /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics/MAPK/MAPKK-ser /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics/MKP-1/diff /kinetics/chain/kinetics/MKP-1 REAC A B addmsg /kinetics/MKP-1/diff /kinetics/chain/kinetics/MKP-1 REAC B A addmsg /kinetics/chain/kinetics/MAPK/MAPK-tyr /kinetics/chain/kinetics/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics/MKP-1 /kinetics/chain/kinetics/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics/MAPK* /kinetics/chain/kinetics/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics/MKP-1 /kinetics/chain/kinetics/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics/MKP-1 /kinetics/chain/kinetics/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MKP-1 /kinetics/chain/kinetics/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics/MAPK/craf-1* /kinetics/chain/kinetics/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics/Ras/GTP-Ras /kinetics/chain/kinetics/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics/PPhosphatase2A/craf-deph /kinetics/chain/kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics/PPhosphatase2A/diff /kinetics/chain/kinetics/PPhosphatase2A REAC A B addmsg /kinetics/PPhosphatase2A/diff /kinetics/chain/kinetics/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics/MAPK/craf-1* /kinetics/chain/kinetics/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics/PPhosphatase2A /kinetics/chain/kinetics/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics/MAPK/MAPKK* /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics/PPhosphatase2A /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics/MAPK/MAPKK-ser /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics/PPhosphatase2A /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics/MAPK/craf-1** /kinetics/chain/kinetics/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics/PPhosphatase2A /kinetics/chain/kinetics/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics/PPhosphatase2A /kinetics/chain/kinetics/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A /kinetics/chain/kinetics/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics/Ras/inact-GEF /kinetics/chain/kinetics/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics/Ras/GEF* /kinetics/chain/kinetics/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC-active/PKC-act-GEF /kinetics/chain/kinetics/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics/Ras/dephosph-GEF /kinetics/chain/kinetics/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics/Ras/CaM-bind-GEF /kinetics/chain/kinetics/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics/Ras/inact-GEF/diff /kinetics/chain/kinetics/Ras/inact-GEF REAC A B addmsg /kinetics/Ras/inact-GEF/diff /kinetics/chain/kinetics/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics/Ras/inact-GEF /kinetics/chain/kinetics/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics/Ras/GDP-Ras /kinetics/chain/kinetics/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/inact-GEF /kinetics/chain/kinetics/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF /kinetics/chain/kinetics/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC-active/PKC-act-GEF /kinetics/chain/kinetics/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics/Ras/dephosph-GEF /kinetics/chain/kinetics/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics/Ras/GEF*/diff /kinetics/chain/kinetics/Ras/GEF* REAC A B addmsg /kinetics/Ras/GEF*/diff /kinetics/chain/kinetics/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics/Ras/GEF* /kinetics/chain/kinetics/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics/Ras/GDP-Ras /kinetics/chain/kinetics/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/GEF* /kinetics/chain/kinetics/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/GEF* /kinetics/chain/kinetics/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics/Ras-act-craf /kinetics/chain/kinetics/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics/Ras-act-unphosph-raf /kinetics/chain/kinetics/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics/Ras/GTP-Ras/diff /kinetics/chain/kinetics/Ras/GTP-Ras REAC A B addmsg /kinetics/Ras/GTP-Ras/diff /kinetics/chain/kinetics/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics/Ras/GTP-Ras /kinetics/chain/kinetics/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/GTP-Ras /kinetics/chain/kinetics/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics/Ras/GDP-Ras/diff /kinetics/chain/kinetics/Ras/GDP-Ras REAC A B addmsg /kinetics/Ras/GDP-Ras/diff /kinetics/chain/kinetics/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics/Ras/GDP-Ras /kinetics/chain/kinetics/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/GDP-Ras /kinetics/chain/kinetics/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics/Ras/GTP-Ras /kinetics/chain/kinetics/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/GDP-Ras /kinetics/chain/kinetics/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics/Ras/GAP* /kinetics/chain/kinetics/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/GAP /kinetics/chain/kinetics/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics/Ras/dephosph-GAP /kinetics/chain/kinetics/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics/Ras/GAP*/diff /kinetics/chain/kinetics/Ras/GAP* REAC A B addmsg /kinetics/Ras/GAP*/diff /kinetics/chain/kinetics/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics/Ras/GAP* /kinetics/chain/kinetics/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/GAP* /kinetics/chain/kinetics/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics/Ras/dephosph-GAP /kinetics/chain/kinetics/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics/Ras/GAP/diff /kinetics/chain/kinetics/Ras/GAP REAC A B addmsg /kinetics/Ras/GAP/diff /kinetics/chain/kinetics/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics/Ras/GTP-Ras /kinetics/chain/kinetics/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/GAP /kinetics/chain/kinetics/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics/Ras/GAP /kinetics/chain/kinetics/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/GAP /kinetics/chain/kinetics/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics/Ras/inact-GEF /kinetics/chain/kinetics/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/CaM-GEF /kinetics/chain/kinetics/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca4 /kinetics/chain/kinetics/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/CaM-bind-GEF /kinetics/chain/kinetics/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics/Ras/CaM-GEF/diff /kinetics/chain/kinetics/Ras/CaM-GEF REAC A B addmsg /kinetics/Ras/CaM-GEF/diff /kinetics/chain/kinetics/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics/Ras/GDP-Ras /kinetics/chain/kinetics/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/CaM-GEF /kinetics/chain/kinetics/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics/Ras/CaM-GEF /kinetics/chain/kinetics/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/CaM-GEF /kinetics/chain/kinetics/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics/CaM/CaM-bind-Ca /kinetics/chain/kinetics/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM/diff /kinetics/chain/kinetics/CaM/CaM REAC A B addmsg /kinetics/CaM/CaM/diff /kinetics/chain/kinetics/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics/CaM/CaM /kinetics/chain/kinetics/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM /kinetics/chain/kinetics/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca3 /kinetics/chain/kinetics/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca4 /kinetics/chain/kinetics/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics/Ca /kinetics/chain/kinetics/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics/CaM/CaM-Ca3/diff /kinetics/chain/kinetics/CaM/CaM-Ca3 REAC A B addmsg /kinetics/CaM/CaM-Ca3/diff /kinetics/chain/kinetics/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics/CaM/CaM-Ca3 /kinetics/chain/kinetics/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca3 /kinetics/chain/kinetics/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics/Ras/CaM-bind-GEF /kinetics/chain/kinetics/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics/PKM/trigger_PKM /kinetics/chain/kinetics/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-Ca4/diff /kinetics/chain/kinetics/CaM/CaM-Ca4 REAC A B addmsg /kinetics/CaM/CaM-Ca4/diff /kinetics/chain/kinetics/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics/CaM/CaM-Ca4 /kinetics/chain/kinetics/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 /kinetics/chain/kinetics/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics/CaM/CaM /kinetics/chain/kinetics/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca /kinetics/chain/kinetics/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics/Ca /kinetics/chain/kinetics/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics/CaM/CaM-Ca2/diff /kinetics/chain/kinetics/CaM/CaM-Ca2 REAC A B addmsg /kinetics/CaM/CaM-Ca2/diff /kinetics/chain/kinetics/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics/CaM/CaM-Ca2 /kinetics/chain/kinetics/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca2 /kinetics/chain/kinetics/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca3 /kinetics/chain/kinetics/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca2 /kinetics/chain/kinetics/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics/Ca /kinetics/chain/kinetics/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca2 /kinetics/chain/kinetics/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca /kinetics/chain/kinetics/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics/Ca /kinetics/chain/kinetics/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM-bind-Ca /kinetics/chain/kinetics/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-Ca/diff /kinetics/chain/kinetics/CaM/CaM-Ca REAC A B addmsg /kinetics/CaM/CaM-Ca/diff /kinetics/chain/kinetics/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics/CaM/CaM-Ca /kinetics/chain/kinetics/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca /kinetics/chain/kinetics/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-act-by-Ca /kinetics/chain/kinetics/Ca REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics/Ca REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-bind-Ca /kinetics/chain/kinetics/Ca REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics/Ca REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics/Ca REAC A B addmsg /kinetics/chain/kinetics/Ca_diff /kinetics/chain/kinetics/Ca REAC B A addmsg /kinetics/chain/kinetics/Ca/diff /kinetics/chain/kinetics/Ca REAC A B addmsg /kinetics/Ca/diff /kinetics/chain/kinetics/Ca REAC B A addmsg /kinetics/chain/kinetics/Ca /kinetics/chain/kinetics/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ca /kinetics/chain/kinetics/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics/MAPK/craf-1 /kinetics/chain/kinetics/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics/Ras/GTP-Ras /kinetics/chain/kinetics/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics/PKM/trigger_PKM /kinetics/chain/kinetics/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics/PKM/Ca_detector/diff /kinetics/chain/kinetics/PKM/Ca_detector REAC A B addmsg /kinetics/PKM/Ca_detector/diff /kinetics/chain/kinetics/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics/PKM/Ca_detector /kinetics/chain/kinetics/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKM/Ca_detector /kinetics/chain/kinetics/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics/PKM/turn_off_activator /kinetics/chain/kinetics/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics/PKM/PKM_synthesis/diff /kinetics/chain/kinetics/PKM/PKM_synthesis REAC A B addmsg /kinetics/PKM/PKM_synthesis/diff /kinetics/chain/kinetics/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics/PKM/PKM_synthesis /kinetics/chain/kinetics/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics/PKM/AA_pool /kinetics/chain/kinetics/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics/PKM/PKM_synthesis /kinetics/chain/kinetics/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKM/PKM_synthesis /kinetics/chain/kinetics/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics/PKC/PKM-zeta /kinetics/chain/kinetics/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics/PKM/degraded_PKM /kinetics/chain/kinetics/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics/PKM/PKM_degradation /kinetics/chain/kinetics/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics/PKM/trigger_PKM /kinetics/chain/kinetics/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics/PKM/Ca.detector_complex REAC A B addmsg /kinetics/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics/PKM/Ca.detector_complex /kinetics/chain/kinetics/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics/PKM/PKM_activator /kinetics/chain/kinetics/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics/PKM/Ca.detector_complex /kinetics/chain/kinetics/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex /kinetics/chain/kinetics/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics/PKM/turn_off_activator /kinetics/chain/kinetics/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics/PKM/PKM_activator/diff /kinetics/chain/kinetics/PKM/PKM_activator REAC A B addmsg /kinetics/PKM/PKM_activator/diff /kinetics/chain/kinetics/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics/PKM/PKM_activator /kinetics/chain/kinetics/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKM/PKM_activator /kinetics/chain/kinetics/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKM/PKM_synthesis /kinetics/chain/kinetics/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics/PKM/PKM_activator /kinetics/chain/kinetics/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca4 /kinetics/chain/kinetics/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics/PKM/Ca_detector /kinetics/chain/kinetics/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics/PKM/Ca.detector_complex /kinetics/chain/kinetics/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics/Ca_diff /kinetics/chain/kinetics/Ca_input REAC A B addmsg /kinetics/chain/kinetics/Ca /kinetics/chain/kinetics/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics/Ca_input /kinetics/chain/kinetics/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[1]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[1]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[1]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-Ca/diff /kinetics/chain/kinetics[1]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[1]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca /kinetics/chain/kinetics[1]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca /kinetics/chain/kinetics[1]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ca /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca /kinetics/chain/kinetics[1]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[1]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[1]/DAG /kinetics/chain/kinetics[1]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca /kinetics/chain/kinetics[1]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[1]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[1]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[1]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/DAG /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG /kinetics/chain/kinetics[1]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-DAG/diff /kinetics/chain/kinetics[1]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[1]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG /kinetics/chain/kinetics[1]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG /kinetics/chain/kinetics[1]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[1]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[1]/PKM/PKM_degradation /kinetics/chain/kinetics[1]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics/PKC/PKM-zeta/diff /kinetics/chain/kinetics[1]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[1]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKM-zeta /kinetics/chain/kinetics[1]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKM-zeta /kinetics/chain/kinetics[1]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[1]/DAG REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG /kinetics/chain/kinetics[1]/DAG REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[1]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[1]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[1]/PKC/PKM-zeta /kinetics/chain/kinetics[1]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[1]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[1]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[1]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[1]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[1]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[1]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[1]/PKC-active /kinetics/chain/kinetics[1]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1 /kinetics/chain/kinetics[1]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC-active /kinetics/chain/kinetics[1]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[1]/Ras/GAP /kinetics/chain/kinetics[1]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC-active /kinetics/chain/kinetics[1]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF /kinetics/chain/kinetics[1]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[1]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[1]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[1]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics/MAPK*/diff /kinetics/chain/kinetics[1]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[1]/MAPK*/diff /kinetics/chain/kinetics[1]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[1]/MAPK* /kinetics/chain/kinetics[1]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1* /kinetics/chain/kinetics[1]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK* /kinetics/chain/kinetics[1]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK* /kinetics/chain/kinetics[1]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[1]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[1]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[1]/Ras-act-unphosph-raf /kinetics/chain/kinetics[1]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics/MAPK/craf-1/diff /kinetics/chain/kinetics[1]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1/diff /kinetics/chain/kinetics[1]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1 /kinetics/chain/kinetics[1]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1 /kinetics/chain/kinetics[1]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[1]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[1]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[1]/Ras-act-craf /kinetics/chain/kinetics[1]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[1]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[1]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/craf-1*/diff /kinetics/chain/kinetics[1]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1*/diff /kinetics/chain/kinetics[1]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1* /kinetics/chain/kinetics[1]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1* /kinetics/chain/kinetics[1]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[1]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[1]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[1]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/MAPKK/diff /kinetics/chain/kinetics[1]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK/diff /kinetics/chain/kinetics[1]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK /kinetics/chain/kinetics[1]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK /kinetics/chain/kinetics[1]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[1]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[1]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[1]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/MAPK/diff /kinetics/chain/kinetics[1]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK/diff /kinetics/chain/kinetics[1]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK /kinetics/chain/kinetics[1]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK /kinetics/chain/kinetics[1]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[1]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[1]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics/MAPK/craf-1**/diff /kinetics/chain/kinetics[1]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1**/diff /kinetics/chain/kinetics[1]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1** /kinetics/chain/kinetics[1]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1** /kinetics/chain/kinetics[1]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[1]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[1]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[1]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[1]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[1]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[1]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[1]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics/MAPK/MAPKK*/diff /kinetics/chain/kinetics[1]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[1]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK* /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK* /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK* /kinetics/chain/kinetics[1]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK* /kinetics/chain/kinetics[1]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[1]/Ras-act-unphosph-raf /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[1]/Ras-act-craf /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[1]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[1]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[1]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics/MKP-1/diff /kinetics/chain/kinetics[1]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[1]/MKP-1/diff /kinetics/chain/kinetics[1]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr /kinetics/chain/kinetics[1]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MKP-1 /kinetics/chain/kinetics[1]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK* /kinetics/chain/kinetics[1]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MKP-1 /kinetics/chain/kinetics[1]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[1]/MKP-1 /kinetics/chain/kinetics[1]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MKP-1 /kinetics/chain/kinetics[1]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1* /kinetics/chain/kinetics[1]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[1]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ras/GTP-Ras /kinetics/chain/kinetics[1]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[1]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[1]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[1]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[1]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics/PPhosphatase2A/diff /kinetics/chain/kinetics[1]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/diff /kinetics/chain/kinetics[1]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1* /kinetics/chain/kinetics[1]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A /kinetics/chain/kinetics[1]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK* /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1** /kinetics/chain/kinetics[1]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A /kinetics/chain/kinetics[1]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A /kinetics/chain/kinetics[1]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A /kinetics/chain/kinetics[1]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF /kinetics/chain/kinetics[1]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ras/GEF* /kinetics/chain/kinetics[1]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[1]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[1]/Ras/dephosph-GEF /kinetics/chain/kinetics[1]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[1]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[1]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[1]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics/Ras/inact-GEF/diff /kinetics/chain/kinetics[1]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF/diff /kinetics/chain/kinetics[1]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF /kinetics/chain/kinetics[1]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[1]/Ras/GDP-Ras /kinetics/chain/kinetics[1]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF /kinetics/chain/kinetics[1]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF /kinetics/chain/kinetics[1]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[1]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[1]/Ras/dephosph-GEF /kinetics/chain/kinetics[1]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[1]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics/Ras/GEF*/diff /kinetics/chain/kinetics[1]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[1]/Ras/GEF*/diff /kinetics/chain/kinetics[1]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/GEF* /kinetics/chain/kinetics[1]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[1]/Ras/GDP-Ras /kinetics/chain/kinetics[1]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/GEF* /kinetics/chain/kinetics[1]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/GEF* /kinetics/chain/kinetics[1]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ras-act-craf /kinetics/chain/kinetics[1]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[1]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[1]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[1]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[1]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[1]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[1]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[1]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[1]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[1]/Ras-act-unphosph-raf /kinetics/chain/kinetics[1]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics/Ras/GTP-Ras/diff /kinetics/chain/kinetics[1]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[1]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[1]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/GTP-Ras /kinetics/chain/kinetics[1]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/GTP-Ras /kinetics/chain/kinetics[1]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[1]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[1]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[1]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[1]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[1]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[1]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[1]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[1]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[1]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics/Ras/GDP-Ras/diff /kinetics/chain/kinetics[1]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[1]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[1]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/GDP-Ras /kinetics/chain/kinetics[1]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/GDP-Ras /kinetics/chain/kinetics[1]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ras/GTP-Ras /kinetics/chain/kinetics[1]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/GDP-Ras /kinetics/chain/kinetics[1]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ras/GAP* /kinetics/chain/kinetics[1]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/GAP /kinetics/chain/kinetics[1]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[1]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[1]/Ras/dephosph-GAP /kinetics/chain/kinetics[1]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics/Ras/GAP*/diff /kinetics/chain/kinetics[1]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[1]/Ras/GAP*/diff /kinetics/chain/kinetics[1]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/GAP* /kinetics/chain/kinetics[1]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/GAP* /kinetics/chain/kinetics[1]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[1]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[1]/Ras/dephosph-GAP /kinetics/chain/kinetics[1]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[1]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[1]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics/Ras/GAP/diff /kinetics/chain/kinetics[1]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[1]/Ras/GAP/diff /kinetics/chain/kinetics[1]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/GTP-Ras /kinetics/chain/kinetics[1]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/GAP /kinetics/chain/kinetics[1]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[1]/Ras/GAP /kinetics/chain/kinetics[1]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/GAP /kinetics/chain/kinetics[1]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF /kinetics/chain/kinetics[1]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/CaM-GEF /kinetics/chain/kinetics[1]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 /kinetics/chain/kinetics[1]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[1]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[1]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[1]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics/Ras/CaM-GEF/diff /kinetics/chain/kinetics[1]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[1]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[1]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/GDP-Ras /kinetics/chain/kinetics[1]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/CaM-GEF /kinetics/chain/kinetics[1]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[1]/Ras/CaM-GEF /kinetics/chain/kinetics[1]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/CaM-GEF /kinetics/chain/kinetics[1]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[1]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM/diff /kinetics/chain/kinetics[1]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[1]/CaM/CaM/diff /kinetics/chain/kinetics[1]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM /kinetics/chain/kinetics[1]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM /kinetics/chain/kinetics[1]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca3 /kinetics/chain/kinetics[1]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 /kinetics/chain/kinetics[1]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[1]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[1]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca3 /kinetics/chain/kinetics[1]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca3 /kinetics/chain/kinetics[1]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[1]/PKM/trigger_PKM /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 /kinetics/chain/kinetics[1]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca4 /kinetics/chain/kinetics[1]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/CaM/CaM /kinetics/chain/kinetics[1]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca /kinetics/chain/kinetics[1]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ca /kinetics/chain/kinetics[1]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[1]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[1]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca2 /kinetics/chain/kinetics[1]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca2 /kinetics/chain/kinetics[1]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca3 /kinetics/chain/kinetics[1]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca2 /kinetics/chain/kinetics[1]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca2 /kinetics/chain/kinetics[1]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-Ca/diff /kinetics/chain/kinetics[1]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[1]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[1]/Ca REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[1]/Ca REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[1]/Ca REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[1]/Ca REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[1]/Ca REAC A B addmsg /kinetics/chain/kinetics[1]/Ca_diff /kinetics/chain/kinetics[1]/Ca REAC B A addmsg /kinetics/chain/kinetics/Ca/diff /kinetics/chain/kinetics[1]/Ca REAC B A addmsg /kinetics/chain/kinetics[1]/Ca/diff /kinetics/chain/kinetics[1]/Ca REAC A B addmsg /kinetics/chain/kinetics[1]/Ca /kinetics/chain/kinetics[1]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ca /kinetics/chain/kinetics[1]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1 /kinetics/chain/kinetics[1]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[1]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ras/GTP-Ras /kinetics/chain/kinetics[1]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKM/trigger_PKM /kinetics/chain/kinetics[1]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics/PKM/Ca_detector/diff /kinetics/chain/kinetics[1]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[1]/PKM/Ca_detector/diff /kinetics/chain/kinetics[1]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[1]/PKM/Ca_detector /kinetics/chain/kinetics[1]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKM/Ca_detector /kinetics/chain/kinetics[1]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[1]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[1]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[1]/PKM/turn_off_activator /kinetics/chain/kinetics[1]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[1]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[1]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[1]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[1]/PKM/PKM_synthesis /kinetics/chain/kinetics[1]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[1]/PKM/AA_pool /kinetics/chain/kinetics[1]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKM/PKM_synthesis /kinetics/chain/kinetics[1]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKM/PKM_synthesis /kinetics/chain/kinetics[1]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[1]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[1]/PKC/PKM-zeta /kinetics/chain/kinetics[1]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKM/degraded_PKM /kinetics/chain/kinetics[1]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKM/PKM_degradation /kinetics/chain/kinetics[1]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[1]/PKM/trigger_PKM /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[1]/PKM/PKM_activator /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[1]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[1]/PKM/turn_off_activator /kinetics/chain/kinetics[1]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics/PKM/PKM_activator/diff /kinetics/chain/kinetics[1]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[1]/PKM/PKM_activator/diff /kinetics/chain/kinetics[1]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[1]/PKM/PKM_activator /kinetics/chain/kinetics[1]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKM/PKM_activator /kinetics/chain/kinetics[1]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKM/PKM_synthesis /kinetics/chain/kinetics[1]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKM/PKM_activator /kinetics/chain/kinetics[1]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 /kinetics/chain/kinetics[1]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKM/Ca_detector /kinetics/chain/kinetics[1]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex /kinetics/chain/kinetics[1]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ca_diff /kinetics/chain/kinetics[1]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[1]/Ca /kinetics/chain/kinetics[1]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ca_input /kinetics/chain/kinetics[1]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[2]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[2]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[2]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[2]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[2]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca /kinetics/chain/kinetics[2]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca /kinetics/chain/kinetics[2]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ca /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca /kinetics/chain/kinetics[2]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[2]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[2]/DAG /kinetics/chain/kinetics[2]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca /kinetics/chain/kinetics[2]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[2]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[2]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[2]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/DAG /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG /kinetics/chain/kinetics[2]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[2]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[2]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG /kinetics/chain/kinetics[2]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG /kinetics/chain/kinetics[2]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[2]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[2]/PKM/PKM_degradation /kinetics/chain/kinetics[2]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[2]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[2]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKM-zeta /kinetics/chain/kinetics[2]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKM-zeta /kinetics/chain/kinetics[2]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[2]/DAG REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG /kinetics/chain/kinetics[2]/DAG REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[2]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[2]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[2]/PKC/PKM-zeta /kinetics/chain/kinetics[2]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[2]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[2]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[2]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[2]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[2]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[2]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[2]/PKC-active /kinetics/chain/kinetics[2]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1 /kinetics/chain/kinetics[2]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC-active /kinetics/chain/kinetics[2]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[2]/Ras/GAP /kinetics/chain/kinetics[2]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC-active /kinetics/chain/kinetics[2]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF /kinetics/chain/kinetics[2]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[2]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[2]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[2]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[1]/MAPK*/diff /kinetics/chain/kinetics[2]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[2]/MAPK*/diff /kinetics/chain/kinetics[2]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[2]/MAPK* /kinetics/chain/kinetics[2]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1* /kinetics/chain/kinetics[2]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK* /kinetics/chain/kinetics[2]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK* /kinetics/chain/kinetics[2]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[2]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[2]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[2]/Ras-act-unphosph-raf /kinetics/chain/kinetics[2]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1/diff /kinetics/chain/kinetics[2]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1/diff /kinetics/chain/kinetics[2]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1 /kinetics/chain/kinetics[2]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1 /kinetics/chain/kinetics[2]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[2]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[2]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[2]/Ras-act-craf /kinetics/chain/kinetics[2]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[2]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[2]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1*/diff /kinetics/chain/kinetics[2]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1*/diff /kinetics/chain/kinetics[2]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1* /kinetics/chain/kinetics[2]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1* /kinetics/chain/kinetics[2]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[2]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[2]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[2]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK/diff /kinetics/chain/kinetics[2]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK/diff /kinetics/chain/kinetics[2]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK /kinetics/chain/kinetics[2]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK /kinetics/chain/kinetics[2]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[2]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[2]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[2]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK/diff /kinetics/chain/kinetics[2]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK/diff /kinetics/chain/kinetics[2]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK /kinetics/chain/kinetics[2]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK /kinetics/chain/kinetics[2]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[2]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[2]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1**/diff /kinetics/chain/kinetics[2]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1**/diff /kinetics/chain/kinetics[2]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1** /kinetics/chain/kinetics[2]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1** /kinetics/chain/kinetics[2]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[2]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[2]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[2]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[2]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[2]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[2]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[2]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[2]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[2]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK* /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK* /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK* /kinetics/chain/kinetics[2]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK* /kinetics/chain/kinetics[2]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[2]/Ras-act-unphosph-raf /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[2]/Ras-act-craf /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[2]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[2]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[2]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[1]/MKP-1/diff /kinetics/chain/kinetics[2]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[2]/MKP-1/diff /kinetics/chain/kinetics[2]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr /kinetics/chain/kinetics[2]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MKP-1 /kinetics/chain/kinetics[2]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK* /kinetics/chain/kinetics[2]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MKP-1 /kinetics/chain/kinetics[2]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[2]/MKP-1 /kinetics/chain/kinetics[2]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MKP-1 /kinetics/chain/kinetics[2]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1* /kinetics/chain/kinetics[2]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[2]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ras/GTP-Ras /kinetics/chain/kinetics[2]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[2]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[2]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[2]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[2]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/diff /kinetics/chain/kinetics[2]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/diff /kinetics/chain/kinetics[2]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1* /kinetics/chain/kinetics[2]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A /kinetics/chain/kinetics[2]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK* /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1** /kinetics/chain/kinetics[2]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A /kinetics/chain/kinetics[2]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A /kinetics/chain/kinetics[2]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A /kinetics/chain/kinetics[2]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF /kinetics/chain/kinetics[2]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ras/GEF* /kinetics/chain/kinetics[2]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[2]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[2]/Ras/dephosph-GEF /kinetics/chain/kinetics[2]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[2]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[2]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[2]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF/diff /kinetics/chain/kinetics[2]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF/diff /kinetics/chain/kinetics[2]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF /kinetics/chain/kinetics[2]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[2]/Ras/GDP-Ras /kinetics/chain/kinetics[2]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF /kinetics/chain/kinetics[2]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF /kinetics/chain/kinetics[2]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[2]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[2]/Ras/dephosph-GEF /kinetics/chain/kinetics[2]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[2]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[1]/Ras/GEF*/diff /kinetics/chain/kinetics[2]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[2]/Ras/GEF*/diff /kinetics/chain/kinetics[2]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/GEF* /kinetics/chain/kinetics[2]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[2]/Ras/GDP-Ras /kinetics/chain/kinetics[2]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/GEF* /kinetics/chain/kinetics[2]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/GEF* /kinetics/chain/kinetics[2]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ras-act-craf /kinetics/chain/kinetics[2]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[2]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[2]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[2]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[2]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[2]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[2]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[2]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[2]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[2]/Ras-act-unphosph-raf /kinetics/chain/kinetics[2]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[2]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[2]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[2]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/GTP-Ras /kinetics/chain/kinetics[2]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/GTP-Ras /kinetics/chain/kinetics[2]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[2]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[2]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[2]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[2]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[2]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[2]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[2]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[2]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[2]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[1]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[2]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[2]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[2]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/GDP-Ras /kinetics/chain/kinetics[2]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/GDP-Ras /kinetics/chain/kinetics[2]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ras/GTP-Ras /kinetics/chain/kinetics[2]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/GDP-Ras /kinetics/chain/kinetics[2]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ras/GAP* /kinetics/chain/kinetics[2]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/GAP /kinetics/chain/kinetics[2]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[2]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[2]/Ras/dephosph-GAP /kinetics/chain/kinetics[2]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/GAP*/diff /kinetics/chain/kinetics[2]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[2]/Ras/GAP*/diff /kinetics/chain/kinetics[2]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/GAP* /kinetics/chain/kinetics[2]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/GAP* /kinetics/chain/kinetics[2]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[2]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[2]/Ras/dephosph-GAP /kinetics/chain/kinetics[2]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[2]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[2]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[1]/Ras/GAP/diff /kinetics/chain/kinetics[2]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[2]/Ras/GAP/diff /kinetics/chain/kinetics[2]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/GTP-Ras /kinetics/chain/kinetics[2]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/GAP /kinetics/chain/kinetics[2]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[2]/Ras/GAP /kinetics/chain/kinetics[2]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/GAP /kinetics/chain/kinetics[2]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF /kinetics/chain/kinetics[2]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/CaM-GEF /kinetics/chain/kinetics[2]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca4 /kinetics/chain/kinetics[2]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[2]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[2]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[2]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[1]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[2]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[2]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[2]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/GDP-Ras /kinetics/chain/kinetics[2]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/CaM-GEF /kinetics/chain/kinetics[2]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[2]/Ras/CaM-GEF /kinetics/chain/kinetics[2]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/CaM-GEF /kinetics/chain/kinetics[2]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[2]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM/diff /kinetics/chain/kinetics[2]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[2]/CaM/CaM/diff /kinetics/chain/kinetics[2]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM /kinetics/chain/kinetics[2]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM /kinetics/chain/kinetics[2]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca3 /kinetics/chain/kinetics[2]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca4 /kinetics/chain/kinetics[2]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[2]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[2]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca3 /kinetics/chain/kinetics[2]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca3 /kinetics/chain/kinetics[2]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[2]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[2]/PKM/trigger_PKM /kinetics/chain/kinetics[2]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[2]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[2]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca4 /kinetics/chain/kinetics[2]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca4 /kinetics/chain/kinetics[2]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/CaM/CaM /kinetics/chain/kinetics[2]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca /kinetics/chain/kinetics[2]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ca /kinetics/chain/kinetics[2]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[2]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[2]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca2 /kinetics/chain/kinetics[2]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca2 /kinetics/chain/kinetics[2]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca3 /kinetics/chain/kinetics[2]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca2 /kinetics/chain/kinetics[2]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca2 /kinetics/chain/kinetics[2]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[2]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[2]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[2]/Ca REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[2]/Ca REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[2]/Ca REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[2]/Ca REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[2]/Ca REAC A B addmsg /kinetics/chain/kinetics[2]/Ca_diff /kinetics/chain/kinetics[2]/Ca REAC B A addmsg /kinetics/chain/kinetics[1]/Ca/diff /kinetics/chain/kinetics[2]/Ca REAC B A addmsg /kinetics/chain/kinetics[2]/Ca/diff /kinetics/chain/kinetics[2]/Ca REAC A B addmsg /kinetics/chain/kinetics[2]/Ca /kinetics/chain/kinetics[2]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ca /kinetics/chain/kinetics[2]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1 /kinetics/chain/kinetics[2]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[2]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ras/GTP-Ras /kinetics/chain/kinetics[2]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKM/trigger_PKM /kinetics/chain/kinetics[2]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[1]/PKM/Ca_detector/diff /kinetics/chain/kinetics[2]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[2]/PKM/Ca_detector/diff /kinetics/chain/kinetics[2]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[2]/PKM/Ca_detector /kinetics/chain/kinetics[2]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKM/Ca_detector /kinetics/chain/kinetics[2]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[2]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[2]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[2]/PKM/turn_off_activator /kinetics/chain/kinetics[2]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[1]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[2]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[2]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[2]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[2]/PKM/PKM_synthesis /kinetics/chain/kinetics[2]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[2]/PKM/AA_pool /kinetics/chain/kinetics[2]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKM/PKM_synthesis /kinetics/chain/kinetics[2]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKM/PKM_synthesis /kinetics/chain/kinetics[2]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[2]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[2]/PKC/PKM-zeta /kinetics/chain/kinetics[2]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKM/degraded_PKM /kinetics/chain/kinetics[2]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKM/PKM_degradation /kinetics/chain/kinetics[2]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[2]/PKM/trigger_PKM /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[1]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[2]/PKM/PKM_activator /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[2]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[2]/PKM/turn_off_activator /kinetics/chain/kinetics[2]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[1]/PKM/PKM_activator/diff /kinetics/chain/kinetics[2]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[2]/PKM/PKM_activator/diff /kinetics/chain/kinetics[2]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[2]/PKM/PKM_activator /kinetics/chain/kinetics[2]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKM/PKM_activator /kinetics/chain/kinetics[2]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKM/PKM_synthesis /kinetics/chain/kinetics[2]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKM/PKM_activator /kinetics/chain/kinetics[2]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca4 /kinetics/chain/kinetics[2]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKM/Ca_detector /kinetics/chain/kinetics[2]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex /kinetics/chain/kinetics[2]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ca_diff /kinetics/chain/kinetics[2]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[2]/Ca /kinetics/chain/kinetics[2]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ca_input /kinetics/chain/kinetics[2]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[3]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[3]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[3]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[3]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[3]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca /kinetics/chain/kinetics[3]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca /kinetics/chain/kinetics[3]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ca /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca /kinetics/chain/kinetics[3]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[3]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[3]/DAG /kinetics/chain/kinetics[3]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca /kinetics/chain/kinetics[3]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[3]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[3]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[3]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/DAG /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG /kinetics/chain/kinetics[3]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[3]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[3]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG /kinetics/chain/kinetics[3]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG /kinetics/chain/kinetics[3]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[3]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[3]/PKM/PKM_degradation /kinetics/chain/kinetics[3]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[3]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[3]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKM-zeta /kinetics/chain/kinetics[3]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKM-zeta /kinetics/chain/kinetics[3]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[3]/DAG REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG /kinetics/chain/kinetics[3]/DAG REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[3]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[3]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[3]/PKC/PKM-zeta /kinetics/chain/kinetics[3]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[3]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[3]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[3]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[3]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[3]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[3]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[3]/PKC-active /kinetics/chain/kinetics[3]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1 /kinetics/chain/kinetics[3]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC-active /kinetics/chain/kinetics[3]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[3]/Ras/GAP /kinetics/chain/kinetics[3]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC-active /kinetics/chain/kinetics[3]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF /kinetics/chain/kinetics[3]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[3]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[3]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[3]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[2]/MAPK*/diff /kinetics/chain/kinetics[3]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[3]/MAPK*/diff /kinetics/chain/kinetics[3]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[3]/MAPK* /kinetics/chain/kinetics[3]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1* /kinetics/chain/kinetics[3]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK* /kinetics/chain/kinetics[3]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK* /kinetics/chain/kinetics[3]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[3]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[3]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[3]/Ras-act-unphosph-raf /kinetics/chain/kinetics[3]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1/diff /kinetics/chain/kinetics[3]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1/diff /kinetics/chain/kinetics[3]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1 /kinetics/chain/kinetics[3]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1 /kinetics/chain/kinetics[3]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[3]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[3]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[3]/Ras-act-craf /kinetics/chain/kinetics[3]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[3]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[3]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1*/diff /kinetics/chain/kinetics[3]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1*/diff /kinetics/chain/kinetics[3]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1* /kinetics/chain/kinetics[3]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1* /kinetics/chain/kinetics[3]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[3]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[3]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[3]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK/diff /kinetics/chain/kinetics[3]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK/diff /kinetics/chain/kinetics[3]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK /kinetics/chain/kinetics[3]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK /kinetics/chain/kinetics[3]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[3]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[3]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[3]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK/diff /kinetics/chain/kinetics[3]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK/diff /kinetics/chain/kinetics[3]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK /kinetics/chain/kinetics[3]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK /kinetics/chain/kinetics[3]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[3]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[3]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1**/diff /kinetics/chain/kinetics[3]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1**/diff /kinetics/chain/kinetics[3]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1** /kinetics/chain/kinetics[3]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1** /kinetics/chain/kinetics[3]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[3]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[3]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[3]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[3]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[3]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[3]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[3]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[3]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[3]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK* /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK* /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK* /kinetics/chain/kinetics[3]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK* /kinetics/chain/kinetics[3]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[3]/Ras-act-unphosph-raf /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[3]/Ras-act-craf /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[3]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[3]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[3]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[2]/MKP-1/diff /kinetics/chain/kinetics[3]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[3]/MKP-1/diff /kinetics/chain/kinetics[3]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr /kinetics/chain/kinetics[3]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MKP-1 /kinetics/chain/kinetics[3]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK* /kinetics/chain/kinetics[3]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MKP-1 /kinetics/chain/kinetics[3]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[3]/MKP-1 /kinetics/chain/kinetics[3]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MKP-1 /kinetics/chain/kinetics[3]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1* /kinetics/chain/kinetics[3]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[3]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ras/GTP-Ras /kinetics/chain/kinetics[3]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[3]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[3]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[3]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[3]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/diff /kinetics/chain/kinetics[3]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/diff /kinetics/chain/kinetics[3]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1* /kinetics/chain/kinetics[3]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A /kinetics/chain/kinetics[3]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK* /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1** /kinetics/chain/kinetics[3]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A /kinetics/chain/kinetics[3]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A /kinetics/chain/kinetics[3]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A /kinetics/chain/kinetics[3]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF /kinetics/chain/kinetics[3]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ras/GEF* /kinetics/chain/kinetics[3]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[3]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[3]/Ras/dephosph-GEF /kinetics/chain/kinetics[3]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[3]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[3]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[3]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF/diff /kinetics/chain/kinetics[3]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF/diff /kinetics/chain/kinetics[3]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF /kinetics/chain/kinetics[3]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[3]/Ras/GDP-Ras /kinetics/chain/kinetics[3]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF /kinetics/chain/kinetics[3]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF /kinetics/chain/kinetics[3]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[3]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[3]/Ras/dephosph-GEF /kinetics/chain/kinetics[3]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[3]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[2]/Ras/GEF*/diff /kinetics/chain/kinetics[3]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[3]/Ras/GEF*/diff /kinetics/chain/kinetics[3]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/GEF* /kinetics/chain/kinetics[3]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[3]/Ras/GDP-Ras /kinetics/chain/kinetics[3]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/GEF* /kinetics/chain/kinetics[3]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/GEF* /kinetics/chain/kinetics[3]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ras-act-craf /kinetics/chain/kinetics[3]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[3]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[3]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[3]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[3]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[3]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[3]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[3]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[3]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[3]/Ras-act-unphosph-raf /kinetics/chain/kinetics[3]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[3]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[3]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[3]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/GTP-Ras /kinetics/chain/kinetics[3]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/GTP-Ras /kinetics/chain/kinetics[3]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[3]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[3]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[3]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[3]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[3]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[3]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[3]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[3]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[3]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[2]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[3]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[3]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[3]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/GDP-Ras /kinetics/chain/kinetics[3]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/GDP-Ras /kinetics/chain/kinetics[3]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ras/GTP-Ras /kinetics/chain/kinetics[3]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/GDP-Ras /kinetics/chain/kinetics[3]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ras/GAP* /kinetics/chain/kinetics[3]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/GAP /kinetics/chain/kinetics[3]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[3]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[3]/Ras/dephosph-GAP /kinetics/chain/kinetics[3]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/GAP*/diff /kinetics/chain/kinetics[3]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[3]/Ras/GAP*/diff /kinetics/chain/kinetics[3]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/GAP* /kinetics/chain/kinetics[3]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/GAP* /kinetics/chain/kinetics[3]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[3]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[3]/Ras/dephosph-GAP /kinetics/chain/kinetics[3]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[3]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[3]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[2]/Ras/GAP/diff /kinetics/chain/kinetics[3]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[3]/Ras/GAP/diff /kinetics/chain/kinetics[3]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/GTP-Ras /kinetics/chain/kinetics[3]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/GAP /kinetics/chain/kinetics[3]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[3]/Ras/GAP /kinetics/chain/kinetics[3]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/GAP /kinetics/chain/kinetics[3]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF /kinetics/chain/kinetics[3]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/CaM-GEF /kinetics/chain/kinetics[3]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca4 /kinetics/chain/kinetics[3]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[3]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[3]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[3]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[2]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[3]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[3]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[3]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/GDP-Ras /kinetics/chain/kinetics[3]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/CaM-GEF /kinetics/chain/kinetics[3]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[3]/Ras/CaM-GEF /kinetics/chain/kinetics[3]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/CaM-GEF /kinetics/chain/kinetics[3]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[3]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM/diff /kinetics/chain/kinetics[3]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[3]/CaM/CaM/diff /kinetics/chain/kinetics[3]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM /kinetics/chain/kinetics[3]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM /kinetics/chain/kinetics[3]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca3 /kinetics/chain/kinetics[3]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca4 /kinetics/chain/kinetics[3]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[3]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[3]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca3 /kinetics/chain/kinetics[3]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca3 /kinetics/chain/kinetics[3]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[3]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[3]/PKM/trigger_PKM /kinetics/chain/kinetics[3]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[3]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[3]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca4 /kinetics/chain/kinetics[3]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca4 /kinetics/chain/kinetics[3]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/CaM/CaM /kinetics/chain/kinetics[3]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca /kinetics/chain/kinetics[3]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ca /kinetics/chain/kinetics[3]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[3]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[3]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca2 /kinetics/chain/kinetics[3]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca2 /kinetics/chain/kinetics[3]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca3 /kinetics/chain/kinetics[3]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca2 /kinetics/chain/kinetics[3]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca2 /kinetics/chain/kinetics[3]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[3]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[3]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[3]/Ca REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[3]/Ca REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[3]/Ca REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[3]/Ca REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[3]/Ca REAC A B addmsg /kinetics/chain/kinetics[3]/Ca_diff /kinetics/chain/kinetics[3]/Ca REAC B A addmsg /kinetics/chain/kinetics[2]/Ca/diff /kinetics/chain/kinetics[3]/Ca REAC B A addmsg /kinetics/chain/kinetics[3]/Ca/diff /kinetics/chain/kinetics[3]/Ca REAC A B addmsg /kinetics/chain/kinetics[3]/Ca /kinetics/chain/kinetics[3]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ca /kinetics/chain/kinetics[3]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1 /kinetics/chain/kinetics[3]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[3]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ras/GTP-Ras /kinetics/chain/kinetics[3]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKM/trigger_PKM /kinetics/chain/kinetics[3]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[2]/PKM/Ca_detector/diff /kinetics/chain/kinetics[3]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[3]/PKM/Ca_detector/diff /kinetics/chain/kinetics[3]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[3]/PKM/Ca_detector /kinetics/chain/kinetics[3]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKM/Ca_detector /kinetics/chain/kinetics[3]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[3]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[3]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[3]/PKM/turn_off_activator /kinetics/chain/kinetics[3]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[2]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[3]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[3]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[3]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[3]/PKM/PKM_synthesis /kinetics/chain/kinetics[3]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[3]/PKM/AA_pool /kinetics/chain/kinetics[3]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKM/PKM_synthesis /kinetics/chain/kinetics[3]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKM/PKM_synthesis /kinetics/chain/kinetics[3]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[3]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[3]/PKC/PKM-zeta /kinetics/chain/kinetics[3]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKM/degraded_PKM /kinetics/chain/kinetics[3]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKM/PKM_degradation /kinetics/chain/kinetics[3]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[3]/PKM/trigger_PKM /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[2]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[3]/PKM/PKM_activator /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[3]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[3]/PKM/turn_off_activator /kinetics/chain/kinetics[3]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[2]/PKM/PKM_activator/diff /kinetics/chain/kinetics[3]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[3]/PKM/PKM_activator/diff /kinetics/chain/kinetics[3]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[3]/PKM/PKM_activator /kinetics/chain/kinetics[3]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKM/PKM_activator /kinetics/chain/kinetics[3]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKM/PKM_synthesis /kinetics/chain/kinetics[3]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKM/PKM_activator /kinetics/chain/kinetics[3]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca4 /kinetics/chain/kinetics[3]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKM/Ca_detector /kinetics/chain/kinetics[3]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex /kinetics/chain/kinetics[3]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ca_diff /kinetics/chain/kinetics[3]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[3]/Ca /kinetics/chain/kinetics[3]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ca_input /kinetics/chain/kinetics[3]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[4]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[4]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[4]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[4]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[4]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca /kinetics/chain/kinetics[4]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca /kinetics/chain/kinetics[4]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ca /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca /kinetics/chain/kinetics[4]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[4]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[4]/DAG /kinetics/chain/kinetics[4]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca /kinetics/chain/kinetics[4]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[4]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[4]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[4]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/DAG /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG /kinetics/chain/kinetics[4]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[4]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[4]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG /kinetics/chain/kinetics[4]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG /kinetics/chain/kinetics[4]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[4]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[4]/PKM/PKM_degradation /kinetics/chain/kinetics[4]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[4]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[4]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKM-zeta /kinetics/chain/kinetics[4]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKM-zeta /kinetics/chain/kinetics[4]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[4]/DAG REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG /kinetics/chain/kinetics[4]/DAG REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[4]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[4]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[4]/PKC/PKM-zeta /kinetics/chain/kinetics[4]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[4]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[4]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[4]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[4]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[4]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[4]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[4]/PKC-active /kinetics/chain/kinetics[4]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1 /kinetics/chain/kinetics[4]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC-active /kinetics/chain/kinetics[4]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[4]/Ras/GAP /kinetics/chain/kinetics[4]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC-active /kinetics/chain/kinetics[4]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF /kinetics/chain/kinetics[4]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[4]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[4]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[4]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[3]/MAPK*/diff /kinetics/chain/kinetics[4]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[4]/MAPK*/diff /kinetics/chain/kinetics[4]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[4]/MAPK* /kinetics/chain/kinetics[4]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1* /kinetics/chain/kinetics[4]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK* /kinetics/chain/kinetics[4]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK* /kinetics/chain/kinetics[4]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[4]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[4]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[4]/Ras-act-unphosph-raf /kinetics/chain/kinetics[4]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1/diff /kinetics/chain/kinetics[4]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1/diff /kinetics/chain/kinetics[4]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1 /kinetics/chain/kinetics[4]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1 /kinetics/chain/kinetics[4]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[4]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[4]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[4]/Ras-act-craf /kinetics/chain/kinetics[4]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[4]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[4]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1*/diff /kinetics/chain/kinetics[4]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1*/diff /kinetics/chain/kinetics[4]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1* /kinetics/chain/kinetics[4]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1* /kinetics/chain/kinetics[4]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[4]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[4]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[4]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK/diff /kinetics/chain/kinetics[4]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK/diff /kinetics/chain/kinetics[4]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK /kinetics/chain/kinetics[4]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK /kinetics/chain/kinetics[4]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[4]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[4]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[4]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK/diff /kinetics/chain/kinetics[4]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK/diff /kinetics/chain/kinetics[4]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK /kinetics/chain/kinetics[4]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK /kinetics/chain/kinetics[4]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[4]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[4]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1**/diff /kinetics/chain/kinetics[4]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1**/diff /kinetics/chain/kinetics[4]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1** /kinetics/chain/kinetics[4]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1** /kinetics/chain/kinetics[4]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[4]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[4]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[4]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[4]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[4]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[4]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[4]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[4]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[4]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK* /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK* /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK* /kinetics/chain/kinetics[4]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK* /kinetics/chain/kinetics[4]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[4]/Ras-act-unphosph-raf /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[4]/Ras-act-craf /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[4]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[4]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[4]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[3]/MKP-1/diff /kinetics/chain/kinetics[4]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[4]/MKP-1/diff /kinetics/chain/kinetics[4]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr /kinetics/chain/kinetics[4]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MKP-1 /kinetics/chain/kinetics[4]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK* /kinetics/chain/kinetics[4]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MKP-1 /kinetics/chain/kinetics[4]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[4]/MKP-1 /kinetics/chain/kinetics[4]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MKP-1 /kinetics/chain/kinetics[4]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1* /kinetics/chain/kinetics[4]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[4]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ras/GTP-Ras /kinetics/chain/kinetics[4]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[4]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[4]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[4]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[4]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/diff /kinetics/chain/kinetics[4]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/diff /kinetics/chain/kinetics[4]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1* /kinetics/chain/kinetics[4]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A /kinetics/chain/kinetics[4]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK* /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1** /kinetics/chain/kinetics[4]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A /kinetics/chain/kinetics[4]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A /kinetics/chain/kinetics[4]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A /kinetics/chain/kinetics[4]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF /kinetics/chain/kinetics[4]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ras/GEF* /kinetics/chain/kinetics[4]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[4]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[4]/Ras/dephosph-GEF /kinetics/chain/kinetics[4]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[4]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[4]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[4]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF/diff /kinetics/chain/kinetics[4]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF/diff /kinetics/chain/kinetics[4]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF /kinetics/chain/kinetics[4]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[4]/Ras/GDP-Ras /kinetics/chain/kinetics[4]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF /kinetics/chain/kinetics[4]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF /kinetics/chain/kinetics[4]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[4]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[4]/Ras/dephosph-GEF /kinetics/chain/kinetics[4]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[4]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[3]/Ras/GEF*/diff /kinetics/chain/kinetics[4]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[4]/Ras/GEF*/diff /kinetics/chain/kinetics[4]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/GEF* /kinetics/chain/kinetics[4]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[4]/Ras/GDP-Ras /kinetics/chain/kinetics[4]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/GEF* /kinetics/chain/kinetics[4]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/GEF* /kinetics/chain/kinetics[4]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ras-act-craf /kinetics/chain/kinetics[4]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[4]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[4]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[4]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[4]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[4]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[4]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[4]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[4]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[4]/Ras-act-unphosph-raf /kinetics/chain/kinetics[4]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[4]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[4]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[4]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/GTP-Ras /kinetics/chain/kinetics[4]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/GTP-Ras /kinetics/chain/kinetics[4]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[4]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[4]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[4]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[4]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[4]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[4]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[4]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[4]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[4]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[3]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[4]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[4]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[4]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/GDP-Ras /kinetics/chain/kinetics[4]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/GDP-Ras /kinetics/chain/kinetics[4]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ras/GTP-Ras /kinetics/chain/kinetics[4]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/GDP-Ras /kinetics/chain/kinetics[4]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ras/GAP* /kinetics/chain/kinetics[4]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/GAP /kinetics/chain/kinetics[4]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[4]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[4]/Ras/dephosph-GAP /kinetics/chain/kinetics[4]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/GAP*/diff /kinetics/chain/kinetics[4]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[4]/Ras/GAP*/diff /kinetics/chain/kinetics[4]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/GAP* /kinetics/chain/kinetics[4]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/GAP* /kinetics/chain/kinetics[4]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[4]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[4]/Ras/dephosph-GAP /kinetics/chain/kinetics[4]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[4]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[4]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[3]/Ras/GAP/diff /kinetics/chain/kinetics[4]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[4]/Ras/GAP/diff /kinetics/chain/kinetics[4]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/GTP-Ras /kinetics/chain/kinetics[4]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/GAP /kinetics/chain/kinetics[4]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[4]/Ras/GAP /kinetics/chain/kinetics[4]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/GAP /kinetics/chain/kinetics[4]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF /kinetics/chain/kinetics[4]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/CaM-GEF /kinetics/chain/kinetics[4]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca4 /kinetics/chain/kinetics[4]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[4]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[4]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[4]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[3]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[4]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[4]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[4]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/GDP-Ras /kinetics/chain/kinetics[4]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/CaM-GEF /kinetics/chain/kinetics[4]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[4]/Ras/CaM-GEF /kinetics/chain/kinetics[4]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/CaM-GEF /kinetics/chain/kinetics[4]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[4]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM/diff /kinetics/chain/kinetics[4]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[4]/CaM/CaM/diff /kinetics/chain/kinetics[4]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM /kinetics/chain/kinetics[4]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM /kinetics/chain/kinetics[4]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca3 /kinetics/chain/kinetics[4]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca4 /kinetics/chain/kinetics[4]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[4]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[4]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca3 /kinetics/chain/kinetics[4]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca3 /kinetics/chain/kinetics[4]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[4]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[4]/PKM/trigger_PKM /kinetics/chain/kinetics[4]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[4]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[4]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca4 /kinetics/chain/kinetics[4]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca4 /kinetics/chain/kinetics[4]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/CaM/CaM /kinetics/chain/kinetics[4]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca /kinetics/chain/kinetics[4]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ca /kinetics/chain/kinetics[4]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[4]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[4]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca2 /kinetics/chain/kinetics[4]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca2 /kinetics/chain/kinetics[4]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca3 /kinetics/chain/kinetics[4]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca2 /kinetics/chain/kinetics[4]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca2 /kinetics/chain/kinetics[4]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[4]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[4]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[4]/Ca REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[4]/Ca REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[4]/Ca REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[4]/Ca REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[4]/Ca REAC A B addmsg /kinetics/chain/kinetics[4]/Ca_diff /kinetics/chain/kinetics[4]/Ca REAC B A addmsg /kinetics/chain/kinetics[3]/Ca/diff /kinetics/chain/kinetics[4]/Ca REAC B A addmsg /kinetics/chain/kinetics[4]/Ca/diff /kinetics/chain/kinetics[4]/Ca REAC A B addmsg /kinetics/chain/kinetics[4]/Ca /kinetics/chain/kinetics[4]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ca /kinetics/chain/kinetics[4]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1 /kinetics/chain/kinetics[4]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[4]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ras/GTP-Ras /kinetics/chain/kinetics[4]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKM/trigger_PKM /kinetics/chain/kinetics[4]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[3]/PKM/Ca_detector/diff /kinetics/chain/kinetics[4]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[4]/PKM/Ca_detector/diff /kinetics/chain/kinetics[4]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[4]/PKM/Ca_detector /kinetics/chain/kinetics[4]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKM/Ca_detector /kinetics/chain/kinetics[4]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[4]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[4]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[4]/PKM/turn_off_activator /kinetics/chain/kinetics[4]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[3]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[4]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[4]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[4]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[4]/PKM/PKM_synthesis /kinetics/chain/kinetics[4]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[4]/PKM/AA_pool /kinetics/chain/kinetics[4]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKM/PKM_synthesis /kinetics/chain/kinetics[4]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKM/PKM_synthesis /kinetics/chain/kinetics[4]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[4]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[4]/PKC/PKM-zeta /kinetics/chain/kinetics[4]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKM/degraded_PKM /kinetics/chain/kinetics[4]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKM/PKM_degradation /kinetics/chain/kinetics[4]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[4]/PKM/trigger_PKM /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[3]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[4]/PKM/PKM_activator /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[4]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[4]/PKM/turn_off_activator /kinetics/chain/kinetics[4]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[3]/PKM/PKM_activator/diff /kinetics/chain/kinetics[4]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[4]/PKM/PKM_activator/diff /kinetics/chain/kinetics[4]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[4]/PKM/PKM_activator /kinetics/chain/kinetics[4]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKM/PKM_activator /kinetics/chain/kinetics[4]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKM/PKM_synthesis /kinetics/chain/kinetics[4]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKM/PKM_activator /kinetics/chain/kinetics[4]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca4 /kinetics/chain/kinetics[4]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKM/Ca_detector /kinetics/chain/kinetics[4]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex /kinetics/chain/kinetics[4]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ca_diff /kinetics/chain/kinetics[4]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[4]/Ca /kinetics/chain/kinetics[4]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ca_input /kinetics/chain/kinetics[4]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[5]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[5]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[5]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[5]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[5]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca /kinetics/chain/kinetics[5]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca /kinetics/chain/kinetics[5]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ca /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca /kinetics/chain/kinetics[5]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[5]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[5]/DAG /kinetics/chain/kinetics[5]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca /kinetics/chain/kinetics[5]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[5]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[5]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[5]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/DAG /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG /kinetics/chain/kinetics[5]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[5]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[5]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG /kinetics/chain/kinetics[5]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG /kinetics/chain/kinetics[5]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[5]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[5]/PKM/PKM_degradation /kinetics/chain/kinetics[5]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[5]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[5]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKM-zeta /kinetics/chain/kinetics[5]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKM-zeta /kinetics/chain/kinetics[5]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[5]/DAG REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG /kinetics/chain/kinetics[5]/DAG REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[5]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[5]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[5]/PKC/PKM-zeta /kinetics/chain/kinetics[5]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[5]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[5]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[5]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[5]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[5]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[5]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[5]/PKC-active /kinetics/chain/kinetics[5]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1 /kinetics/chain/kinetics[5]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC-active /kinetics/chain/kinetics[5]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[5]/Ras/GAP /kinetics/chain/kinetics[5]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC-active /kinetics/chain/kinetics[5]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF /kinetics/chain/kinetics[5]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[5]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[5]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[5]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[4]/MAPK*/diff /kinetics/chain/kinetics[5]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[5]/MAPK*/diff /kinetics/chain/kinetics[5]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[5]/MAPK* /kinetics/chain/kinetics[5]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1* /kinetics/chain/kinetics[5]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK* /kinetics/chain/kinetics[5]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK* /kinetics/chain/kinetics[5]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[5]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[5]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[5]/Ras-act-unphosph-raf /kinetics/chain/kinetics[5]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1/diff /kinetics/chain/kinetics[5]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1/diff /kinetics/chain/kinetics[5]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1 /kinetics/chain/kinetics[5]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1 /kinetics/chain/kinetics[5]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[5]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[5]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[5]/Ras-act-craf /kinetics/chain/kinetics[5]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[5]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[5]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1*/diff /kinetics/chain/kinetics[5]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1*/diff /kinetics/chain/kinetics[5]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1* /kinetics/chain/kinetics[5]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1* /kinetics/chain/kinetics[5]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[5]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[5]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[5]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK/diff /kinetics/chain/kinetics[5]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK/diff /kinetics/chain/kinetics[5]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK /kinetics/chain/kinetics[5]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK /kinetics/chain/kinetics[5]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[5]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[5]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[5]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK/diff /kinetics/chain/kinetics[5]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK/diff /kinetics/chain/kinetics[5]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK /kinetics/chain/kinetics[5]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK /kinetics/chain/kinetics[5]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[5]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[5]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1**/diff /kinetics/chain/kinetics[5]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1**/diff /kinetics/chain/kinetics[5]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1** /kinetics/chain/kinetics[5]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1** /kinetics/chain/kinetics[5]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[5]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[5]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[5]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[5]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[5]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[5]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[5]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[5]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[5]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK* /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK* /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK* /kinetics/chain/kinetics[5]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK* /kinetics/chain/kinetics[5]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[5]/Ras-act-unphosph-raf /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[5]/Ras-act-craf /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[5]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[5]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[5]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[4]/MKP-1/diff /kinetics/chain/kinetics[5]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[5]/MKP-1/diff /kinetics/chain/kinetics[5]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr /kinetics/chain/kinetics[5]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MKP-1 /kinetics/chain/kinetics[5]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK* /kinetics/chain/kinetics[5]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MKP-1 /kinetics/chain/kinetics[5]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[5]/MKP-1 /kinetics/chain/kinetics[5]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MKP-1 /kinetics/chain/kinetics[5]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1* /kinetics/chain/kinetics[5]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[5]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ras/GTP-Ras /kinetics/chain/kinetics[5]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[5]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[5]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[5]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[5]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/diff /kinetics/chain/kinetics[5]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/diff /kinetics/chain/kinetics[5]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1* /kinetics/chain/kinetics[5]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A /kinetics/chain/kinetics[5]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK* /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1** /kinetics/chain/kinetics[5]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A /kinetics/chain/kinetics[5]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A /kinetics/chain/kinetics[5]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A /kinetics/chain/kinetics[5]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF /kinetics/chain/kinetics[5]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ras/GEF* /kinetics/chain/kinetics[5]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[5]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[5]/Ras/dephosph-GEF /kinetics/chain/kinetics[5]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[5]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[5]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[5]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF/diff /kinetics/chain/kinetics[5]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF/diff /kinetics/chain/kinetics[5]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF /kinetics/chain/kinetics[5]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[5]/Ras/GDP-Ras /kinetics/chain/kinetics[5]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF /kinetics/chain/kinetics[5]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF /kinetics/chain/kinetics[5]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[5]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[5]/Ras/dephosph-GEF /kinetics/chain/kinetics[5]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[5]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[4]/Ras/GEF*/diff /kinetics/chain/kinetics[5]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[5]/Ras/GEF*/diff /kinetics/chain/kinetics[5]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/GEF* /kinetics/chain/kinetics[5]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[5]/Ras/GDP-Ras /kinetics/chain/kinetics[5]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/GEF* /kinetics/chain/kinetics[5]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/GEF* /kinetics/chain/kinetics[5]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ras-act-craf /kinetics/chain/kinetics[5]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[5]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[5]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[5]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[5]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[5]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[5]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[5]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[5]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[5]/Ras-act-unphosph-raf /kinetics/chain/kinetics[5]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[5]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[5]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[5]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/GTP-Ras /kinetics/chain/kinetics[5]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/GTP-Ras /kinetics/chain/kinetics[5]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[5]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[5]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[5]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[5]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[5]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[5]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[5]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[5]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[5]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[4]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[5]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[5]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[5]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/GDP-Ras /kinetics/chain/kinetics[5]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/GDP-Ras /kinetics/chain/kinetics[5]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ras/GTP-Ras /kinetics/chain/kinetics[5]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/GDP-Ras /kinetics/chain/kinetics[5]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ras/GAP* /kinetics/chain/kinetics[5]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/GAP /kinetics/chain/kinetics[5]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[5]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[5]/Ras/dephosph-GAP /kinetics/chain/kinetics[5]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/GAP*/diff /kinetics/chain/kinetics[5]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[5]/Ras/GAP*/diff /kinetics/chain/kinetics[5]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/GAP* /kinetics/chain/kinetics[5]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/GAP* /kinetics/chain/kinetics[5]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[5]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[5]/Ras/dephosph-GAP /kinetics/chain/kinetics[5]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[5]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[5]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[4]/Ras/GAP/diff /kinetics/chain/kinetics[5]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[5]/Ras/GAP/diff /kinetics/chain/kinetics[5]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/GTP-Ras /kinetics/chain/kinetics[5]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/GAP /kinetics/chain/kinetics[5]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[5]/Ras/GAP /kinetics/chain/kinetics[5]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/GAP /kinetics/chain/kinetics[5]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF /kinetics/chain/kinetics[5]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/CaM-GEF /kinetics/chain/kinetics[5]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca4 /kinetics/chain/kinetics[5]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[5]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[5]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[5]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[4]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[5]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[5]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[5]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/GDP-Ras /kinetics/chain/kinetics[5]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/CaM-GEF /kinetics/chain/kinetics[5]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[5]/Ras/CaM-GEF /kinetics/chain/kinetics[5]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/CaM-GEF /kinetics/chain/kinetics[5]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[5]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM/diff /kinetics/chain/kinetics[5]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[5]/CaM/CaM/diff /kinetics/chain/kinetics[5]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM /kinetics/chain/kinetics[5]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM /kinetics/chain/kinetics[5]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca3 /kinetics/chain/kinetics[5]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca4 /kinetics/chain/kinetics[5]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[5]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[5]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca3 /kinetics/chain/kinetics[5]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca3 /kinetics/chain/kinetics[5]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[5]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[5]/PKM/trigger_PKM /kinetics/chain/kinetics[5]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[5]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[5]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca4 /kinetics/chain/kinetics[5]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 /kinetics/chain/kinetics[5]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/CaM/CaM /kinetics/chain/kinetics[5]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca /kinetics/chain/kinetics[5]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ca /kinetics/chain/kinetics[5]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[5]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[5]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca2 /kinetics/chain/kinetics[5]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca2 /kinetics/chain/kinetics[5]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca3 /kinetics/chain/kinetics[5]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca2 /kinetics/chain/kinetics[5]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca2 /kinetics/chain/kinetics[5]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[5]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[5]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[5]/Ca REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[5]/Ca REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[5]/Ca REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[5]/Ca REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[5]/Ca REAC A B addmsg /kinetics/chain/kinetics[5]/Ca_diff /kinetics/chain/kinetics[5]/Ca REAC B A addmsg /kinetics/chain/kinetics[4]/Ca/diff /kinetics/chain/kinetics[5]/Ca REAC B A addmsg /kinetics/chain/kinetics[5]/Ca/diff /kinetics/chain/kinetics[5]/Ca REAC A B addmsg /kinetics/chain/kinetics[5]/Ca /kinetics/chain/kinetics[5]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ca /kinetics/chain/kinetics[5]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1 /kinetics/chain/kinetics[5]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[5]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ras/GTP-Ras /kinetics/chain/kinetics[5]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKM/trigger_PKM /kinetics/chain/kinetics[5]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[4]/PKM/Ca_detector/diff /kinetics/chain/kinetics[5]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[5]/PKM/Ca_detector/diff /kinetics/chain/kinetics[5]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[5]/PKM/Ca_detector /kinetics/chain/kinetics[5]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKM/Ca_detector /kinetics/chain/kinetics[5]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[5]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[5]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[5]/PKM/turn_off_activator /kinetics/chain/kinetics[5]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[4]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[5]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[5]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[5]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[5]/PKM/PKM_synthesis /kinetics/chain/kinetics[5]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[5]/PKM/AA_pool /kinetics/chain/kinetics[5]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKM/PKM_synthesis /kinetics/chain/kinetics[5]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKM/PKM_synthesis /kinetics/chain/kinetics[5]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[5]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[5]/PKC/PKM-zeta /kinetics/chain/kinetics[5]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKM/degraded_PKM /kinetics/chain/kinetics[5]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKM/PKM_degradation /kinetics/chain/kinetics[5]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[5]/PKM/trigger_PKM /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[4]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[5]/PKM/PKM_activator /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[5]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[5]/PKM/turn_off_activator /kinetics/chain/kinetics[5]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[4]/PKM/PKM_activator/diff /kinetics/chain/kinetics[5]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[5]/PKM/PKM_activator/diff /kinetics/chain/kinetics[5]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[5]/PKM/PKM_activator /kinetics/chain/kinetics[5]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKM/PKM_activator /kinetics/chain/kinetics[5]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKM/PKM_synthesis /kinetics/chain/kinetics[5]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKM/PKM_activator /kinetics/chain/kinetics[5]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca4 /kinetics/chain/kinetics[5]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKM/Ca_detector /kinetics/chain/kinetics[5]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex /kinetics/chain/kinetics[5]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ca_diff /kinetics/chain/kinetics[5]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[5]/Ca /kinetics/chain/kinetics[5]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ca_input /kinetics/chain/kinetics[5]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[6]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[6]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[6]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[6]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[6]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca /kinetics/chain/kinetics[6]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca /kinetics/chain/kinetics[6]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ca /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca /kinetics/chain/kinetics[6]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[6]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[6]/DAG /kinetics/chain/kinetics[6]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca /kinetics/chain/kinetics[6]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[6]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[6]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[6]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/DAG /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG /kinetics/chain/kinetics[6]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[6]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[6]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG /kinetics/chain/kinetics[6]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG /kinetics/chain/kinetics[6]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[6]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[6]/PKM/PKM_degradation /kinetics/chain/kinetics[6]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[6]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[6]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKM-zeta /kinetics/chain/kinetics[6]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKM-zeta /kinetics/chain/kinetics[6]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[6]/DAG REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG /kinetics/chain/kinetics[6]/DAG REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[6]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[6]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[6]/PKC/PKM-zeta /kinetics/chain/kinetics[6]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[6]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[6]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[6]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[6]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[6]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[6]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[6]/PKC-active /kinetics/chain/kinetics[6]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1 /kinetics/chain/kinetics[6]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC-active /kinetics/chain/kinetics[6]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[6]/Ras/GAP /kinetics/chain/kinetics[6]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC-active /kinetics/chain/kinetics[6]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF /kinetics/chain/kinetics[6]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[6]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[6]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[6]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[5]/MAPK*/diff /kinetics/chain/kinetics[6]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[6]/MAPK*/diff /kinetics/chain/kinetics[6]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[6]/MAPK* /kinetics/chain/kinetics[6]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1* /kinetics/chain/kinetics[6]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK* /kinetics/chain/kinetics[6]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK* /kinetics/chain/kinetics[6]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[6]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[6]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[6]/Ras-act-unphosph-raf /kinetics/chain/kinetics[6]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1/diff /kinetics/chain/kinetics[6]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1/diff /kinetics/chain/kinetics[6]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1 /kinetics/chain/kinetics[6]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1 /kinetics/chain/kinetics[6]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[6]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[6]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[6]/Ras-act-craf /kinetics/chain/kinetics[6]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[6]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[6]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1*/diff /kinetics/chain/kinetics[6]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1*/diff /kinetics/chain/kinetics[6]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1* /kinetics/chain/kinetics[6]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1* /kinetics/chain/kinetics[6]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[6]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[6]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[6]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK/diff /kinetics/chain/kinetics[6]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK/diff /kinetics/chain/kinetics[6]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK /kinetics/chain/kinetics[6]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK /kinetics/chain/kinetics[6]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[6]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[6]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[6]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK/diff /kinetics/chain/kinetics[6]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK/diff /kinetics/chain/kinetics[6]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK /kinetics/chain/kinetics[6]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK /kinetics/chain/kinetics[6]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[6]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[6]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1**/diff /kinetics/chain/kinetics[6]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1**/diff /kinetics/chain/kinetics[6]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1** /kinetics/chain/kinetics[6]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1** /kinetics/chain/kinetics[6]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[6]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[6]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[6]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[6]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[6]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[6]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[6]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[6]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[6]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK* /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK* /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK* /kinetics/chain/kinetics[6]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK* /kinetics/chain/kinetics[6]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[6]/Ras-act-unphosph-raf /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[6]/Ras-act-craf /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[6]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[6]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[6]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[5]/MKP-1/diff /kinetics/chain/kinetics[6]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[6]/MKP-1/diff /kinetics/chain/kinetics[6]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr /kinetics/chain/kinetics[6]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MKP-1 /kinetics/chain/kinetics[6]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK* /kinetics/chain/kinetics[6]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MKP-1 /kinetics/chain/kinetics[6]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[6]/MKP-1 /kinetics/chain/kinetics[6]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MKP-1 /kinetics/chain/kinetics[6]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1* /kinetics/chain/kinetics[6]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[6]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ras/GTP-Ras /kinetics/chain/kinetics[6]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[6]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[6]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[6]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[6]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/diff /kinetics/chain/kinetics[6]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/diff /kinetics/chain/kinetics[6]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1* /kinetics/chain/kinetics[6]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A /kinetics/chain/kinetics[6]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK* /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1** /kinetics/chain/kinetics[6]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A /kinetics/chain/kinetics[6]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A /kinetics/chain/kinetics[6]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A /kinetics/chain/kinetics[6]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF /kinetics/chain/kinetics[6]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ras/GEF* /kinetics/chain/kinetics[6]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[6]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[6]/Ras/dephosph-GEF /kinetics/chain/kinetics[6]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[6]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[6]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[6]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF/diff /kinetics/chain/kinetics[6]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF/diff /kinetics/chain/kinetics[6]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF /kinetics/chain/kinetics[6]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[6]/Ras/GDP-Ras /kinetics/chain/kinetics[6]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF /kinetics/chain/kinetics[6]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF /kinetics/chain/kinetics[6]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[6]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[6]/Ras/dephosph-GEF /kinetics/chain/kinetics[6]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[6]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[5]/Ras/GEF*/diff /kinetics/chain/kinetics[6]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[6]/Ras/GEF*/diff /kinetics/chain/kinetics[6]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/GEF* /kinetics/chain/kinetics[6]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[6]/Ras/GDP-Ras /kinetics/chain/kinetics[6]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/GEF* /kinetics/chain/kinetics[6]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/GEF* /kinetics/chain/kinetics[6]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ras-act-craf /kinetics/chain/kinetics[6]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[6]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[6]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[6]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[6]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[6]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[6]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[6]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[6]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[6]/Ras-act-unphosph-raf /kinetics/chain/kinetics[6]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[6]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[6]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[6]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/GTP-Ras /kinetics/chain/kinetics[6]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/GTP-Ras /kinetics/chain/kinetics[6]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[6]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[6]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[6]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[6]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[6]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[6]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[6]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[6]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[6]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[5]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[6]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[6]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[6]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/GDP-Ras /kinetics/chain/kinetics[6]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/GDP-Ras /kinetics/chain/kinetics[6]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ras/GTP-Ras /kinetics/chain/kinetics[6]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/GDP-Ras /kinetics/chain/kinetics[6]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ras/GAP* /kinetics/chain/kinetics[6]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/GAP /kinetics/chain/kinetics[6]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[6]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[6]/Ras/dephosph-GAP /kinetics/chain/kinetics[6]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/GAP*/diff /kinetics/chain/kinetics[6]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[6]/Ras/GAP*/diff /kinetics/chain/kinetics[6]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/GAP* /kinetics/chain/kinetics[6]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/GAP* /kinetics/chain/kinetics[6]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[6]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[6]/Ras/dephosph-GAP /kinetics/chain/kinetics[6]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[6]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[6]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[5]/Ras/GAP/diff /kinetics/chain/kinetics[6]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[6]/Ras/GAP/diff /kinetics/chain/kinetics[6]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/GTP-Ras /kinetics/chain/kinetics[6]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/GAP /kinetics/chain/kinetics[6]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[6]/Ras/GAP /kinetics/chain/kinetics[6]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/GAP /kinetics/chain/kinetics[6]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF /kinetics/chain/kinetics[6]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/CaM-GEF /kinetics/chain/kinetics[6]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 /kinetics/chain/kinetics[6]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[6]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[6]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[6]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[5]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[6]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[6]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[6]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/GDP-Ras /kinetics/chain/kinetics[6]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/CaM-GEF /kinetics/chain/kinetics[6]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[6]/Ras/CaM-GEF /kinetics/chain/kinetics[6]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/CaM-GEF /kinetics/chain/kinetics[6]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[6]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM/diff /kinetics/chain/kinetics[6]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[6]/CaM/CaM/diff /kinetics/chain/kinetics[6]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM /kinetics/chain/kinetics[6]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM /kinetics/chain/kinetics[6]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca3 /kinetics/chain/kinetics[6]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 /kinetics/chain/kinetics[6]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[6]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[6]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca3 /kinetics/chain/kinetics[6]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca3 /kinetics/chain/kinetics[6]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[6]/PKM/trigger_PKM /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 /kinetics/chain/kinetics[6]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 /kinetics/chain/kinetics[6]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/CaM/CaM /kinetics/chain/kinetics[6]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca /kinetics/chain/kinetics[6]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ca /kinetics/chain/kinetics[6]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[6]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[6]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca2 /kinetics/chain/kinetics[6]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca2 /kinetics/chain/kinetics[6]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca3 /kinetics/chain/kinetics[6]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca2 /kinetics/chain/kinetics[6]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca2 /kinetics/chain/kinetics[6]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[6]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[6]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[6]/Ca REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[6]/Ca REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[6]/Ca REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[6]/Ca REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[6]/Ca REAC A B addmsg /kinetics/chain/kinetics[6]/Ca_diff /kinetics/chain/kinetics[6]/Ca REAC B A addmsg /kinetics/chain/kinetics[5]/Ca/diff /kinetics/chain/kinetics[6]/Ca REAC B A addmsg /kinetics/chain/kinetics[6]/Ca/diff /kinetics/chain/kinetics[6]/Ca REAC A B addmsg /kinetics/chain/kinetics[6]/Ca /kinetics/chain/kinetics[6]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ca /kinetics/chain/kinetics[6]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1 /kinetics/chain/kinetics[6]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[6]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ras/GTP-Ras /kinetics/chain/kinetics[6]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKM/trigger_PKM /kinetics/chain/kinetics[6]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[5]/PKM/Ca_detector/diff /kinetics/chain/kinetics[6]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[6]/PKM/Ca_detector/diff /kinetics/chain/kinetics[6]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[6]/PKM/Ca_detector /kinetics/chain/kinetics[6]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKM/Ca_detector /kinetics/chain/kinetics[6]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[6]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[6]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[6]/PKM/turn_off_activator /kinetics/chain/kinetics[6]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[5]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[6]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[6]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[6]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[6]/PKM/PKM_synthesis /kinetics/chain/kinetics[6]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[6]/PKM/AA_pool /kinetics/chain/kinetics[6]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKM/PKM_synthesis /kinetics/chain/kinetics[6]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKM/PKM_synthesis /kinetics/chain/kinetics[6]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[6]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[6]/PKC/PKM-zeta /kinetics/chain/kinetics[6]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKM/degraded_PKM /kinetics/chain/kinetics[6]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKM/PKM_degradation /kinetics/chain/kinetics[6]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[6]/PKM/trigger_PKM /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[5]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[6]/PKM/PKM_activator /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[6]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[6]/PKM/turn_off_activator /kinetics/chain/kinetics[6]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[5]/PKM/PKM_activator/diff /kinetics/chain/kinetics[6]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[6]/PKM/PKM_activator/diff /kinetics/chain/kinetics[6]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[6]/PKM/PKM_activator /kinetics/chain/kinetics[6]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKM/PKM_activator /kinetics/chain/kinetics[6]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKM/PKM_synthesis /kinetics/chain/kinetics[6]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKM/PKM_activator /kinetics/chain/kinetics[6]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 /kinetics/chain/kinetics[6]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKM/Ca_detector /kinetics/chain/kinetics[6]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex /kinetics/chain/kinetics[6]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ca_diff /kinetics/chain/kinetics[6]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[6]/Ca /kinetics/chain/kinetics[6]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ca_input /kinetics/chain/kinetics[6]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[7]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[7]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[7]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[7]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[7]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca /kinetics/chain/kinetics[7]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca /kinetics/chain/kinetics[7]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ca /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca /kinetics/chain/kinetics[7]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[7]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[7]/DAG /kinetics/chain/kinetics[7]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca /kinetics/chain/kinetics[7]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[7]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[7]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[7]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/DAG /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG /kinetics/chain/kinetics[7]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[7]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[7]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG /kinetics/chain/kinetics[7]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG /kinetics/chain/kinetics[7]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[7]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[7]/PKM/PKM_degradation /kinetics/chain/kinetics[7]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[7]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[7]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKM-zeta /kinetics/chain/kinetics[7]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKM-zeta /kinetics/chain/kinetics[7]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[7]/DAG REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG /kinetics/chain/kinetics[7]/DAG REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[7]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[7]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[7]/PKC/PKM-zeta /kinetics/chain/kinetics[7]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[7]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[7]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[7]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[7]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[7]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[7]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[7]/PKC-active /kinetics/chain/kinetics[7]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1 /kinetics/chain/kinetics[7]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC-active /kinetics/chain/kinetics[7]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[7]/Ras/GAP /kinetics/chain/kinetics[7]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC-active /kinetics/chain/kinetics[7]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF /kinetics/chain/kinetics[7]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[7]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[7]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[7]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[6]/MAPK*/diff /kinetics/chain/kinetics[7]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[7]/MAPK*/diff /kinetics/chain/kinetics[7]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[7]/MAPK* /kinetics/chain/kinetics[7]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1* /kinetics/chain/kinetics[7]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK* /kinetics/chain/kinetics[7]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK* /kinetics/chain/kinetics[7]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[7]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[7]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[7]/Ras-act-unphosph-raf /kinetics/chain/kinetics[7]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1/diff /kinetics/chain/kinetics[7]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1/diff /kinetics/chain/kinetics[7]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1 /kinetics/chain/kinetics[7]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1 /kinetics/chain/kinetics[7]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[7]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[7]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[7]/Ras-act-craf /kinetics/chain/kinetics[7]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[7]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[7]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1*/diff /kinetics/chain/kinetics[7]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1*/diff /kinetics/chain/kinetics[7]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1* /kinetics/chain/kinetics[7]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1* /kinetics/chain/kinetics[7]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[7]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[7]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[7]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK/diff /kinetics/chain/kinetics[7]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK/diff /kinetics/chain/kinetics[7]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK /kinetics/chain/kinetics[7]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK /kinetics/chain/kinetics[7]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[7]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[7]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[7]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK/diff /kinetics/chain/kinetics[7]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK/diff /kinetics/chain/kinetics[7]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK /kinetics/chain/kinetics[7]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK /kinetics/chain/kinetics[7]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[7]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[7]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1**/diff /kinetics/chain/kinetics[7]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1**/diff /kinetics/chain/kinetics[7]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1** /kinetics/chain/kinetics[7]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1** /kinetics/chain/kinetics[7]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[7]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[7]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[7]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[7]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[7]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[7]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[7]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[7]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[7]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK* /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK* /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK* /kinetics/chain/kinetics[7]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK* /kinetics/chain/kinetics[7]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[7]/Ras-act-unphosph-raf /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[7]/Ras-act-craf /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[7]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[7]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[7]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[6]/MKP-1/diff /kinetics/chain/kinetics[7]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[7]/MKP-1/diff /kinetics/chain/kinetics[7]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr /kinetics/chain/kinetics[7]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MKP-1 /kinetics/chain/kinetics[7]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK* /kinetics/chain/kinetics[7]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MKP-1 /kinetics/chain/kinetics[7]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[7]/MKP-1 /kinetics/chain/kinetics[7]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MKP-1 /kinetics/chain/kinetics[7]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1* /kinetics/chain/kinetics[7]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[7]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ras/GTP-Ras /kinetics/chain/kinetics[7]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[7]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[7]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[7]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[7]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/diff /kinetics/chain/kinetics[7]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/diff /kinetics/chain/kinetics[7]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1* /kinetics/chain/kinetics[7]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A /kinetics/chain/kinetics[7]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK* /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1** /kinetics/chain/kinetics[7]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A /kinetics/chain/kinetics[7]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A /kinetics/chain/kinetics[7]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A /kinetics/chain/kinetics[7]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF /kinetics/chain/kinetics[7]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ras/GEF* /kinetics/chain/kinetics[7]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[7]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[7]/Ras/dephosph-GEF /kinetics/chain/kinetics[7]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[7]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[7]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[7]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF/diff /kinetics/chain/kinetics[7]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF/diff /kinetics/chain/kinetics[7]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF /kinetics/chain/kinetics[7]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[7]/Ras/GDP-Ras /kinetics/chain/kinetics[7]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF /kinetics/chain/kinetics[7]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF /kinetics/chain/kinetics[7]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[7]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[7]/Ras/dephosph-GEF /kinetics/chain/kinetics[7]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[7]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[6]/Ras/GEF*/diff /kinetics/chain/kinetics[7]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[7]/Ras/GEF*/diff /kinetics/chain/kinetics[7]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/GEF* /kinetics/chain/kinetics[7]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[7]/Ras/GDP-Ras /kinetics/chain/kinetics[7]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/GEF* /kinetics/chain/kinetics[7]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/GEF* /kinetics/chain/kinetics[7]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ras-act-craf /kinetics/chain/kinetics[7]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[7]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[7]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[7]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[7]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[7]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[7]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[7]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[7]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[7]/Ras-act-unphosph-raf /kinetics/chain/kinetics[7]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[7]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[7]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[7]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/GTP-Ras /kinetics/chain/kinetics[7]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/GTP-Ras /kinetics/chain/kinetics[7]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[7]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[7]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[7]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[7]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[7]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[7]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[7]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[7]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[7]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[6]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[7]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[7]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[7]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/GDP-Ras /kinetics/chain/kinetics[7]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/GDP-Ras /kinetics/chain/kinetics[7]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ras/GTP-Ras /kinetics/chain/kinetics[7]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/GDP-Ras /kinetics/chain/kinetics[7]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ras/GAP* /kinetics/chain/kinetics[7]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/GAP /kinetics/chain/kinetics[7]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[7]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[7]/Ras/dephosph-GAP /kinetics/chain/kinetics[7]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/GAP*/diff /kinetics/chain/kinetics[7]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[7]/Ras/GAP*/diff /kinetics/chain/kinetics[7]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/GAP* /kinetics/chain/kinetics[7]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/GAP* /kinetics/chain/kinetics[7]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[7]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[7]/Ras/dephosph-GAP /kinetics/chain/kinetics[7]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[7]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[7]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[6]/Ras/GAP/diff /kinetics/chain/kinetics[7]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[7]/Ras/GAP/diff /kinetics/chain/kinetics[7]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/GTP-Ras /kinetics/chain/kinetics[7]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/GAP /kinetics/chain/kinetics[7]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[7]/Ras/GAP /kinetics/chain/kinetics[7]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/GAP /kinetics/chain/kinetics[7]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF /kinetics/chain/kinetics[7]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/CaM-GEF /kinetics/chain/kinetics[7]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 /kinetics/chain/kinetics[7]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[7]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[7]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[7]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[6]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[7]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[7]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[7]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/GDP-Ras /kinetics/chain/kinetics[7]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/CaM-GEF /kinetics/chain/kinetics[7]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[7]/Ras/CaM-GEF /kinetics/chain/kinetics[7]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/CaM-GEF /kinetics/chain/kinetics[7]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[7]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM/diff /kinetics/chain/kinetics[7]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[7]/CaM/CaM/diff /kinetics/chain/kinetics[7]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM /kinetics/chain/kinetics[7]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM /kinetics/chain/kinetics[7]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca3 /kinetics/chain/kinetics[7]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 /kinetics/chain/kinetics[7]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[7]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[7]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca3 /kinetics/chain/kinetics[7]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca3 /kinetics/chain/kinetics[7]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[7]/PKM/trigger_PKM /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 /kinetics/chain/kinetics[7]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca4 /kinetics/chain/kinetics[7]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/CaM/CaM /kinetics/chain/kinetics[7]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca /kinetics/chain/kinetics[7]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ca /kinetics/chain/kinetics[7]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[7]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[7]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca2 /kinetics/chain/kinetics[7]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca2 /kinetics/chain/kinetics[7]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca3 /kinetics/chain/kinetics[7]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca2 /kinetics/chain/kinetics[7]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca2 /kinetics/chain/kinetics[7]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[7]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[7]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[7]/Ca REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[7]/Ca REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[7]/Ca REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[7]/Ca REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[7]/Ca REAC A B addmsg /kinetics/chain/kinetics[7]/Ca_diff /kinetics/chain/kinetics[7]/Ca REAC B A addmsg /kinetics/chain/kinetics[6]/Ca/diff /kinetics/chain/kinetics[7]/Ca REAC B A addmsg /kinetics/chain/kinetics[7]/Ca/diff /kinetics/chain/kinetics[7]/Ca REAC A B addmsg /kinetics/chain/kinetics[7]/Ca /kinetics/chain/kinetics[7]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ca /kinetics/chain/kinetics[7]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1 /kinetics/chain/kinetics[7]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[7]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ras/GTP-Ras /kinetics/chain/kinetics[7]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKM/trigger_PKM /kinetics/chain/kinetics[7]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[6]/PKM/Ca_detector/diff /kinetics/chain/kinetics[7]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[7]/PKM/Ca_detector/diff /kinetics/chain/kinetics[7]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[7]/PKM/Ca_detector /kinetics/chain/kinetics[7]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKM/Ca_detector /kinetics/chain/kinetics[7]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[7]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[7]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[7]/PKM/turn_off_activator /kinetics/chain/kinetics[7]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[6]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[7]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[7]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[7]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[7]/PKM/PKM_synthesis /kinetics/chain/kinetics[7]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[7]/PKM/AA_pool /kinetics/chain/kinetics[7]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKM/PKM_synthesis /kinetics/chain/kinetics[7]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKM/PKM_synthesis /kinetics/chain/kinetics[7]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[7]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[7]/PKC/PKM-zeta /kinetics/chain/kinetics[7]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKM/degraded_PKM /kinetics/chain/kinetics[7]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKM/PKM_degradation /kinetics/chain/kinetics[7]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[7]/PKM/trigger_PKM /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[6]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[7]/PKM/PKM_activator /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[7]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[7]/PKM/turn_off_activator /kinetics/chain/kinetics[7]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[6]/PKM/PKM_activator/diff /kinetics/chain/kinetics[7]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[7]/PKM/PKM_activator/diff /kinetics/chain/kinetics[7]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[7]/PKM/PKM_activator /kinetics/chain/kinetics[7]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKM/PKM_activator /kinetics/chain/kinetics[7]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKM/PKM_synthesis /kinetics/chain/kinetics[7]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKM/PKM_activator /kinetics/chain/kinetics[7]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 /kinetics/chain/kinetics[7]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKM/Ca_detector /kinetics/chain/kinetics[7]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex /kinetics/chain/kinetics[7]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ca_diff /kinetics/chain/kinetics[7]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[7]/Ca /kinetics/chain/kinetics[7]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ca_input /kinetics/chain/kinetics[7]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[8]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[8]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[8]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[8]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[8]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca /kinetics/chain/kinetics[8]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca /kinetics/chain/kinetics[8]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ca /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca /kinetics/chain/kinetics[8]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[8]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[8]/DAG /kinetics/chain/kinetics[8]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca /kinetics/chain/kinetics[8]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[8]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[8]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[8]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/DAG /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG /kinetics/chain/kinetics[8]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[8]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[8]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG /kinetics/chain/kinetics[8]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG /kinetics/chain/kinetics[8]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[8]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[8]/PKM/PKM_degradation /kinetics/chain/kinetics[8]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[8]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[8]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKM-zeta /kinetics/chain/kinetics[8]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKM-zeta /kinetics/chain/kinetics[8]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[8]/DAG REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG /kinetics/chain/kinetics[8]/DAG REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[8]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[8]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[8]/PKC/PKM-zeta /kinetics/chain/kinetics[8]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[8]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[8]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[8]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[8]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[8]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[8]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[8]/PKC-active /kinetics/chain/kinetics[8]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1 /kinetics/chain/kinetics[8]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC-active /kinetics/chain/kinetics[8]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[8]/Ras/GAP /kinetics/chain/kinetics[8]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC-active /kinetics/chain/kinetics[8]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF /kinetics/chain/kinetics[8]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[8]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[8]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[8]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[7]/MAPK*/diff /kinetics/chain/kinetics[8]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[8]/MAPK*/diff /kinetics/chain/kinetics[8]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[8]/MAPK* /kinetics/chain/kinetics[8]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1* /kinetics/chain/kinetics[8]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK* /kinetics/chain/kinetics[8]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK* /kinetics/chain/kinetics[8]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[8]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[8]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[8]/Ras-act-unphosph-raf /kinetics/chain/kinetics[8]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1/diff /kinetics/chain/kinetics[8]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1/diff /kinetics/chain/kinetics[8]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1 /kinetics/chain/kinetics[8]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1 /kinetics/chain/kinetics[8]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[8]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[8]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[8]/Ras-act-craf /kinetics/chain/kinetics[8]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[8]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[8]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1*/diff /kinetics/chain/kinetics[8]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1*/diff /kinetics/chain/kinetics[8]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1* /kinetics/chain/kinetics[8]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1* /kinetics/chain/kinetics[8]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[8]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[8]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[8]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK/diff /kinetics/chain/kinetics[8]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK/diff /kinetics/chain/kinetics[8]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK /kinetics/chain/kinetics[8]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK /kinetics/chain/kinetics[8]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[8]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[8]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[8]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK/diff /kinetics/chain/kinetics[8]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK/diff /kinetics/chain/kinetics[8]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK /kinetics/chain/kinetics[8]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK /kinetics/chain/kinetics[8]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[8]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[8]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1**/diff /kinetics/chain/kinetics[8]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1**/diff /kinetics/chain/kinetics[8]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1** /kinetics/chain/kinetics[8]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1** /kinetics/chain/kinetics[8]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[8]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[8]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[8]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[8]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[8]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[8]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[8]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[8]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[8]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK* /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK* /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK* /kinetics/chain/kinetics[8]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK* /kinetics/chain/kinetics[8]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[8]/Ras-act-unphosph-raf /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[8]/Ras-act-craf /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[8]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[8]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[8]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[7]/MKP-1/diff /kinetics/chain/kinetics[8]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[8]/MKP-1/diff /kinetics/chain/kinetics[8]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr /kinetics/chain/kinetics[8]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MKP-1 /kinetics/chain/kinetics[8]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK* /kinetics/chain/kinetics[8]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MKP-1 /kinetics/chain/kinetics[8]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[8]/MKP-1 /kinetics/chain/kinetics[8]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MKP-1 /kinetics/chain/kinetics[8]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1* /kinetics/chain/kinetics[8]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[8]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ras/GTP-Ras /kinetics/chain/kinetics[8]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[8]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[8]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[8]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[8]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/diff /kinetics/chain/kinetics[8]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/diff /kinetics/chain/kinetics[8]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1* /kinetics/chain/kinetics[8]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A /kinetics/chain/kinetics[8]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK* /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1** /kinetics/chain/kinetics[8]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A /kinetics/chain/kinetics[8]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A /kinetics/chain/kinetics[8]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A /kinetics/chain/kinetics[8]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF /kinetics/chain/kinetics[8]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ras/GEF* /kinetics/chain/kinetics[8]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[8]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[8]/Ras/dephosph-GEF /kinetics/chain/kinetics[8]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[8]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[8]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[8]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF/diff /kinetics/chain/kinetics[8]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF/diff /kinetics/chain/kinetics[8]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF /kinetics/chain/kinetics[8]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[8]/Ras/GDP-Ras /kinetics/chain/kinetics[8]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF /kinetics/chain/kinetics[8]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF /kinetics/chain/kinetics[8]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[8]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[8]/Ras/dephosph-GEF /kinetics/chain/kinetics[8]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[8]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[7]/Ras/GEF*/diff /kinetics/chain/kinetics[8]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[8]/Ras/GEF*/diff /kinetics/chain/kinetics[8]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/GEF* /kinetics/chain/kinetics[8]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[8]/Ras/GDP-Ras /kinetics/chain/kinetics[8]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/GEF* /kinetics/chain/kinetics[8]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/GEF* /kinetics/chain/kinetics[8]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ras-act-craf /kinetics/chain/kinetics[8]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[8]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[8]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[8]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[8]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[8]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[8]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[8]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[8]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[8]/Ras-act-unphosph-raf /kinetics/chain/kinetics[8]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[8]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[8]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[8]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/GTP-Ras /kinetics/chain/kinetics[8]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/GTP-Ras /kinetics/chain/kinetics[8]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[8]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[8]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[8]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[8]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[8]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[8]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[8]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[8]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[8]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[7]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[8]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[8]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[8]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/GDP-Ras /kinetics/chain/kinetics[8]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/GDP-Ras /kinetics/chain/kinetics[8]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ras/GTP-Ras /kinetics/chain/kinetics[8]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/GDP-Ras /kinetics/chain/kinetics[8]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ras/GAP* /kinetics/chain/kinetics[8]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/GAP /kinetics/chain/kinetics[8]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[8]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[8]/Ras/dephosph-GAP /kinetics/chain/kinetics[8]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/GAP*/diff /kinetics/chain/kinetics[8]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[8]/Ras/GAP*/diff /kinetics/chain/kinetics[8]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/GAP* /kinetics/chain/kinetics[8]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/GAP* /kinetics/chain/kinetics[8]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[8]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[8]/Ras/dephosph-GAP /kinetics/chain/kinetics[8]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[8]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[8]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[7]/Ras/GAP/diff /kinetics/chain/kinetics[8]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[8]/Ras/GAP/diff /kinetics/chain/kinetics[8]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/GTP-Ras /kinetics/chain/kinetics[8]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/GAP /kinetics/chain/kinetics[8]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[8]/Ras/GAP /kinetics/chain/kinetics[8]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/GAP /kinetics/chain/kinetics[8]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF /kinetics/chain/kinetics[8]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/CaM-GEF /kinetics/chain/kinetics[8]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca4 /kinetics/chain/kinetics[8]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[8]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[8]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[8]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[7]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[8]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[8]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[8]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/GDP-Ras /kinetics/chain/kinetics[8]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/CaM-GEF /kinetics/chain/kinetics[8]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[8]/Ras/CaM-GEF /kinetics/chain/kinetics[8]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/CaM-GEF /kinetics/chain/kinetics[8]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[8]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM/diff /kinetics/chain/kinetics[8]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[8]/CaM/CaM/diff /kinetics/chain/kinetics[8]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM /kinetics/chain/kinetics[8]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM /kinetics/chain/kinetics[8]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca3 /kinetics/chain/kinetics[8]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca4 /kinetics/chain/kinetics[8]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[8]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[8]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca3 /kinetics/chain/kinetics[8]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca3 /kinetics/chain/kinetics[8]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[8]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[8]/PKM/trigger_PKM /kinetics/chain/kinetics[8]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[8]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[8]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca4 /kinetics/chain/kinetics[8]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca4 /kinetics/chain/kinetics[8]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/CaM/CaM /kinetics/chain/kinetics[8]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca /kinetics/chain/kinetics[8]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ca /kinetics/chain/kinetics[8]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[8]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[8]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca2 /kinetics/chain/kinetics[8]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca2 /kinetics/chain/kinetics[8]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca3 /kinetics/chain/kinetics[8]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca2 /kinetics/chain/kinetics[8]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca2 /kinetics/chain/kinetics[8]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[8]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[8]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[8]/Ca REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[8]/Ca REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[8]/Ca REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[8]/Ca REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[8]/Ca REAC A B addmsg /kinetics/chain/kinetics[8]/Ca_diff /kinetics/chain/kinetics[8]/Ca REAC B A addmsg /kinetics/chain/kinetics[7]/Ca/diff /kinetics/chain/kinetics[8]/Ca REAC B A addmsg /kinetics/chain/kinetics[8]/Ca/diff /kinetics/chain/kinetics[8]/Ca REAC A B addmsg /kinetics/chain/kinetics[8]/Ca /kinetics/chain/kinetics[8]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ca /kinetics/chain/kinetics[8]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1 /kinetics/chain/kinetics[8]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[8]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ras/GTP-Ras /kinetics/chain/kinetics[8]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKM/trigger_PKM /kinetics/chain/kinetics[8]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[7]/PKM/Ca_detector/diff /kinetics/chain/kinetics[8]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[8]/PKM/Ca_detector/diff /kinetics/chain/kinetics[8]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[8]/PKM/Ca_detector /kinetics/chain/kinetics[8]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKM/Ca_detector /kinetics/chain/kinetics[8]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[8]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[8]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[8]/PKM/turn_off_activator /kinetics/chain/kinetics[8]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[7]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[8]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[8]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[8]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[8]/PKM/PKM_synthesis /kinetics/chain/kinetics[8]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[8]/PKM/AA_pool /kinetics/chain/kinetics[8]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKM/PKM_synthesis /kinetics/chain/kinetics[8]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKM/PKM_synthesis /kinetics/chain/kinetics[8]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[8]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[8]/PKC/PKM-zeta /kinetics/chain/kinetics[8]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKM/degraded_PKM /kinetics/chain/kinetics[8]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKM/PKM_degradation /kinetics/chain/kinetics[8]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[8]/PKM/trigger_PKM /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[7]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[8]/PKM/PKM_activator /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[8]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[8]/PKM/turn_off_activator /kinetics/chain/kinetics[8]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[7]/PKM/PKM_activator/diff /kinetics/chain/kinetics[8]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[8]/PKM/PKM_activator/diff /kinetics/chain/kinetics[8]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[8]/PKM/PKM_activator /kinetics/chain/kinetics[8]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKM/PKM_activator /kinetics/chain/kinetics[8]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKM/PKM_synthesis /kinetics/chain/kinetics[8]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKM/PKM_activator /kinetics/chain/kinetics[8]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca4 /kinetics/chain/kinetics[8]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKM/Ca_detector /kinetics/chain/kinetics[8]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex /kinetics/chain/kinetics[8]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ca_diff /kinetics/chain/kinetics[8]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[8]/Ca /kinetics/chain/kinetics[8]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ca_input /kinetics/chain/kinetics[8]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[9]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[9]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[9]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[9]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[9]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca /kinetics/chain/kinetics[9]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca /kinetics/chain/kinetics[9]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ca /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca /kinetics/chain/kinetics[9]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[9]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[9]/DAG /kinetics/chain/kinetics[9]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca /kinetics/chain/kinetics[9]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[9]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[9]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[9]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/DAG /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG /kinetics/chain/kinetics[9]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[9]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[9]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG /kinetics/chain/kinetics[9]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG /kinetics/chain/kinetics[9]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[9]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[9]/PKM/PKM_degradation /kinetics/chain/kinetics[9]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[9]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[9]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKM-zeta /kinetics/chain/kinetics[9]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKM-zeta /kinetics/chain/kinetics[9]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[9]/DAG REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG /kinetics/chain/kinetics[9]/DAG REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[9]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[9]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[9]/PKC/PKM-zeta /kinetics/chain/kinetics[9]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[9]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[9]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[9]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[9]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[9]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[9]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[9]/PKC-active /kinetics/chain/kinetics[9]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1 /kinetics/chain/kinetics[9]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC-active /kinetics/chain/kinetics[9]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[9]/Ras/GAP /kinetics/chain/kinetics[9]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC-active /kinetics/chain/kinetics[9]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF /kinetics/chain/kinetics[9]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[9]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[9]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[9]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[8]/MAPK*/diff /kinetics/chain/kinetics[9]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[9]/MAPK*/diff /kinetics/chain/kinetics[9]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[9]/MAPK* /kinetics/chain/kinetics[9]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1* /kinetics/chain/kinetics[9]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK* /kinetics/chain/kinetics[9]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK* /kinetics/chain/kinetics[9]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[9]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[9]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[9]/Ras-act-unphosph-raf /kinetics/chain/kinetics[9]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1/diff /kinetics/chain/kinetics[9]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1/diff /kinetics/chain/kinetics[9]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1 /kinetics/chain/kinetics[9]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1 /kinetics/chain/kinetics[9]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[9]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[9]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[9]/Ras-act-craf /kinetics/chain/kinetics[9]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[9]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[9]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1*/diff /kinetics/chain/kinetics[9]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1*/diff /kinetics/chain/kinetics[9]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1* /kinetics/chain/kinetics[9]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1* /kinetics/chain/kinetics[9]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[9]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[9]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[9]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK/diff /kinetics/chain/kinetics[9]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK/diff /kinetics/chain/kinetics[9]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK /kinetics/chain/kinetics[9]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK /kinetics/chain/kinetics[9]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[9]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[9]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[9]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK/diff /kinetics/chain/kinetics[9]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK/diff /kinetics/chain/kinetics[9]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK /kinetics/chain/kinetics[9]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK /kinetics/chain/kinetics[9]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[9]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[9]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1**/diff /kinetics/chain/kinetics[9]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1**/diff /kinetics/chain/kinetics[9]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1** /kinetics/chain/kinetics[9]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1** /kinetics/chain/kinetics[9]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[9]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[9]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[9]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[9]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[9]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[9]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[9]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[9]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[9]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK* /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK* /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK* /kinetics/chain/kinetics[9]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK* /kinetics/chain/kinetics[9]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[9]/Ras-act-unphosph-raf /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[9]/Ras-act-craf /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[9]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[9]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[9]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[8]/MKP-1/diff /kinetics/chain/kinetics[9]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[9]/MKP-1/diff /kinetics/chain/kinetics[9]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr /kinetics/chain/kinetics[9]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MKP-1 /kinetics/chain/kinetics[9]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK* /kinetics/chain/kinetics[9]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MKP-1 /kinetics/chain/kinetics[9]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[9]/MKP-1 /kinetics/chain/kinetics[9]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MKP-1 /kinetics/chain/kinetics[9]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1* /kinetics/chain/kinetics[9]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[9]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ras/GTP-Ras /kinetics/chain/kinetics[9]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[9]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[9]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[9]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[9]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/diff /kinetics/chain/kinetics[9]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/diff /kinetics/chain/kinetics[9]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1* /kinetics/chain/kinetics[9]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A /kinetics/chain/kinetics[9]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK* /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1** /kinetics/chain/kinetics[9]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A /kinetics/chain/kinetics[9]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A /kinetics/chain/kinetics[9]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A /kinetics/chain/kinetics[9]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF /kinetics/chain/kinetics[9]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ras/GEF* /kinetics/chain/kinetics[9]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[9]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[9]/Ras/dephosph-GEF /kinetics/chain/kinetics[9]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[9]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[9]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[9]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF/diff /kinetics/chain/kinetics[9]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF/diff /kinetics/chain/kinetics[9]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF /kinetics/chain/kinetics[9]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[9]/Ras/GDP-Ras /kinetics/chain/kinetics[9]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF /kinetics/chain/kinetics[9]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF /kinetics/chain/kinetics[9]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[9]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[9]/Ras/dephosph-GEF /kinetics/chain/kinetics[9]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[9]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[8]/Ras/GEF*/diff /kinetics/chain/kinetics[9]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[9]/Ras/GEF*/diff /kinetics/chain/kinetics[9]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/GEF* /kinetics/chain/kinetics[9]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[9]/Ras/GDP-Ras /kinetics/chain/kinetics[9]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/GEF* /kinetics/chain/kinetics[9]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/GEF* /kinetics/chain/kinetics[9]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ras-act-craf /kinetics/chain/kinetics[9]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[9]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[9]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[9]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[9]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[9]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[9]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[9]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[9]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[9]/Ras-act-unphosph-raf /kinetics/chain/kinetics[9]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[9]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[9]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[9]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/GTP-Ras /kinetics/chain/kinetics[9]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/GTP-Ras /kinetics/chain/kinetics[9]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[9]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[9]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[9]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[9]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[9]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[9]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[9]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[9]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[9]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[8]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[9]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[9]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[9]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/GDP-Ras /kinetics/chain/kinetics[9]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/GDP-Ras /kinetics/chain/kinetics[9]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ras/GTP-Ras /kinetics/chain/kinetics[9]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/GDP-Ras /kinetics/chain/kinetics[9]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ras/GAP* /kinetics/chain/kinetics[9]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/GAP /kinetics/chain/kinetics[9]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[9]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[9]/Ras/dephosph-GAP /kinetics/chain/kinetics[9]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/GAP*/diff /kinetics/chain/kinetics[9]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[9]/Ras/GAP*/diff /kinetics/chain/kinetics[9]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/GAP* /kinetics/chain/kinetics[9]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/GAP* /kinetics/chain/kinetics[9]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[9]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[9]/Ras/dephosph-GAP /kinetics/chain/kinetics[9]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[9]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[9]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[8]/Ras/GAP/diff /kinetics/chain/kinetics[9]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[9]/Ras/GAP/diff /kinetics/chain/kinetics[9]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/GTP-Ras /kinetics/chain/kinetics[9]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/GAP /kinetics/chain/kinetics[9]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[9]/Ras/GAP /kinetics/chain/kinetics[9]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/GAP /kinetics/chain/kinetics[9]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF /kinetics/chain/kinetics[9]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/CaM-GEF /kinetics/chain/kinetics[9]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca4 /kinetics/chain/kinetics[9]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[9]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[9]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[9]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[8]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[9]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[9]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[9]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/GDP-Ras /kinetics/chain/kinetics[9]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/CaM-GEF /kinetics/chain/kinetics[9]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[9]/Ras/CaM-GEF /kinetics/chain/kinetics[9]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/CaM-GEF /kinetics/chain/kinetics[9]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[9]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM/diff /kinetics/chain/kinetics[9]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[9]/CaM/CaM/diff /kinetics/chain/kinetics[9]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM /kinetics/chain/kinetics[9]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM /kinetics/chain/kinetics[9]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca3 /kinetics/chain/kinetics[9]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca4 /kinetics/chain/kinetics[9]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[9]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[9]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca3 /kinetics/chain/kinetics[9]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca3 /kinetics/chain/kinetics[9]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[9]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[9]/PKM/trigger_PKM /kinetics/chain/kinetics[9]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[9]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[9]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca4 /kinetics/chain/kinetics[9]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca4 /kinetics/chain/kinetics[9]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/CaM/CaM /kinetics/chain/kinetics[9]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca /kinetics/chain/kinetics[9]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ca /kinetics/chain/kinetics[9]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[9]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[9]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca2 /kinetics/chain/kinetics[9]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca2 /kinetics/chain/kinetics[9]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca3 /kinetics/chain/kinetics[9]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca2 /kinetics/chain/kinetics[9]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca2 /kinetics/chain/kinetics[9]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[9]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[9]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[9]/Ca REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[9]/Ca REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[9]/Ca REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[9]/Ca REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[9]/Ca REAC A B addmsg /kinetics/chain/kinetics[9]/Ca_diff /kinetics/chain/kinetics[9]/Ca REAC B A addmsg /kinetics/chain/kinetics[8]/Ca/diff /kinetics/chain/kinetics[9]/Ca REAC B A addmsg /kinetics/chain/kinetics[9]/Ca/diff /kinetics/chain/kinetics[9]/Ca REAC A B addmsg /kinetics/chain/kinetics[9]/Ca /kinetics/chain/kinetics[9]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ca /kinetics/chain/kinetics[9]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1 /kinetics/chain/kinetics[9]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[9]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ras/GTP-Ras /kinetics/chain/kinetics[9]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKM/trigger_PKM /kinetics/chain/kinetics[9]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[8]/PKM/Ca_detector/diff /kinetics/chain/kinetics[9]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[9]/PKM/Ca_detector/diff /kinetics/chain/kinetics[9]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[9]/PKM/Ca_detector /kinetics/chain/kinetics[9]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKM/Ca_detector /kinetics/chain/kinetics[9]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[9]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[9]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[9]/PKM/turn_off_activator /kinetics/chain/kinetics[9]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[8]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[9]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[9]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[9]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[9]/PKM/PKM_synthesis /kinetics/chain/kinetics[9]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[9]/PKM/AA_pool /kinetics/chain/kinetics[9]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKM/PKM_synthesis /kinetics/chain/kinetics[9]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKM/PKM_synthesis /kinetics/chain/kinetics[9]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[9]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[9]/PKC/PKM-zeta /kinetics/chain/kinetics[9]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKM/degraded_PKM /kinetics/chain/kinetics[9]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKM/PKM_degradation /kinetics/chain/kinetics[9]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[9]/PKM/trigger_PKM /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[8]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[9]/PKM/PKM_activator /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[9]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[9]/PKM/turn_off_activator /kinetics/chain/kinetics[9]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[8]/PKM/PKM_activator/diff /kinetics/chain/kinetics[9]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[9]/PKM/PKM_activator/diff /kinetics/chain/kinetics[9]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[9]/PKM/PKM_activator /kinetics/chain/kinetics[9]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKM/PKM_activator /kinetics/chain/kinetics[9]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKM/PKM_synthesis /kinetics/chain/kinetics[9]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKM/PKM_activator /kinetics/chain/kinetics[9]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca4 /kinetics/chain/kinetics[9]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKM/Ca_detector /kinetics/chain/kinetics[9]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex /kinetics/chain/kinetics[9]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ca_diff /kinetics/chain/kinetics[9]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[9]/Ca /kinetics/chain/kinetics[9]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ca_input /kinetics/chain/kinetics[9]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[10]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[10]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[10]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[10]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[10]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca /kinetics/chain/kinetics[10]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca /kinetics/chain/kinetics[10]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ca /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca /kinetics/chain/kinetics[10]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[10]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[10]/DAG /kinetics/chain/kinetics[10]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca /kinetics/chain/kinetics[10]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[10]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[10]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[10]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/DAG /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG /kinetics/chain/kinetics[10]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[10]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[10]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG /kinetics/chain/kinetics[10]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG /kinetics/chain/kinetics[10]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[10]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[10]/PKM/PKM_degradation /kinetics/chain/kinetics[10]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[10]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[10]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKM-zeta /kinetics/chain/kinetics[10]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKM-zeta /kinetics/chain/kinetics[10]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[10]/DAG REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG /kinetics/chain/kinetics[10]/DAG REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[10]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[10]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[10]/PKC/PKM-zeta /kinetics/chain/kinetics[10]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[10]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[10]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[10]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[10]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[10]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[10]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[10]/PKC-active /kinetics/chain/kinetics[10]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1 /kinetics/chain/kinetics[10]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC-active /kinetics/chain/kinetics[10]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[10]/Ras/GAP /kinetics/chain/kinetics[10]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC-active /kinetics/chain/kinetics[10]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF /kinetics/chain/kinetics[10]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[10]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[10]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[10]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[9]/MAPK*/diff /kinetics/chain/kinetics[10]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[10]/MAPK*/diff /kinetics/chain/kinetics[10]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[10]/MAPK* /kinetics/chain/kinetics[10]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1* /kinetics/chain/kinetics[10]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK* /kinetics/chain/kinetics[10]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK* /kinetics/chain/kinetics[10]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[10]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[10]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[10]/Ras-act-unphosph-raf /kinetics/chain/kinetics[10]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1/diff /kinetics/chain/kinetics[10]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1/diff /kinetics/chain/kinetics[10]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1 /kinetics/chain/kinetics[10]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1 /kinetics/chain/kinetics[10]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[10]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[10]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[10]/Ras-act-craf /kinetics/chain/kinetics[10]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[10]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[10]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1*/diff /kinetics/chain/kinetics[10]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1*/diff /kinetics/chain/kinetics[10]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1* /kinetics/chain/kinetics[10]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1* /kinetics/chain/kinetics[10]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[10]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[10]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[10]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK/diff /kinetics/chain/kinetics[10]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK/diff /kinetics/chain/kinetics[10]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK /kinetics/chain/kinetics[10]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK /kinetics/chain/kinetics[10]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[10]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[10]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[10]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK/diff /kinetics/chain/kinetics[10]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK/diff /kinetics/chain/kinetics[10]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK /kinetics/chain/kinetics[10]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK /kinetics/chain/kinetics[10]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[10]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[10]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1**/diff /kinetics/chain/kinetics[10]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1**/diff /kinetics/chain/kinetics[10]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1** /kinetics/chain/kinetics[10]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1** /kinetics/chain/kinetics[10]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[10]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[10]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[10]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[10]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[10]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[10]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[10]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[10]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[10]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK* /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK* /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK* /kinetics/chain/kinetics[10]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK* /kinetics/chain/kinetics[10]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[10]/Ras-act-unphosph-raf /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[10]/Ras-act-craf /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[10]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[10]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[10]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[9]/MKP-1/diff /kinetics/chain/kinetics[10]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[10]/MKP-1/diff /kinetics/chain/kinetics[10]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr /kinetics/chain/kinetics[10]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MKP-1 /kinetics/chain/kinetics[10]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK* /kinetics/chain/kinetics[10]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MKP-1 /kinetics/chain/kinetics[10]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[10]/MKP-1 /kinetics/chain/kinetics[10]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MKP-1 /kinetics/chain/kinetics[10]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1* /kinetics/chain/kinetics[10]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[10]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ras/GTP-Ras /kinetics/chain/kinetics[10]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[10]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[10]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[10]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[10]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/diff /kinetics/chain/kinetics[10]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/diff /kinetics/chain/kinetics[10]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1* /kinetics/chain/kinetics[10]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A /kinetics/chain/kinetics[10]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK* /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1** /kinetics/chain/kinetics[10]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A /kinetics/chain/kinetics[10]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A /kinetics/chain/kinetics[10]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A /kinetics/chain/kinetics[10]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF /kinetics/chain/kinetics[10]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ras/GEF* /kinetics/chain/kinetics[10]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[10]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[10]/Ras/dephosph-GEF /kinetics/chain/kinetics[10]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[10]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[10]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[10]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF/diff /kinetics/chain/kinetics[10]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF/diff /kinetics/chain/kinetics[10]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF /kinetics/chain/kinetics[10]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[10]/Ras/GDP-Ras /kinetics/chain/kinetics[10]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF /kinetics/chain/kinetics[10]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF /kinetics/chain/kinetics[10]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[10]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[10]/Ras/dephosph-GEF /kinetics/chain/kinetics[10]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[10]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[9]/Ras/GEF*/diff /kinetics/chain/kinetics[10]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[10]/Ras/GEF*/diff /kinetics/chain/kinetics[10]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/GEF* /kinetics/chain/kinetics[10]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[10]/Ras/GDP-Ras /kinetics/chain/kinetics[10]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/GEF* /kinetics/chain/kinetics[10]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/GEF* /kinetics/chain/kinetics[10]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ras-act-craf /kinetics/chain/kinetics[10]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[10]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[10]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[10]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[10]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[10]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[10]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[10]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[10]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[10]/Ras-act-unphosph-raf /kinetics/chain/kinetics[10]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[10]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[10]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[10]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/GTP-Ras /kinetics/chain/kinetics[10]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/GTP-Ras /kinetics/chain/kinetics[10]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[10]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[10]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[10]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[10]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[10]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[10]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[10]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[10]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[10]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[9]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[10]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[10]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[10]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/GDP-Ras /kinetics/chain/kinetics[10]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/GDP-Ras /kinetics/chain/kinetics[10]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ras/GTP-Ras /kinetics/chain/kinetics[10]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/GDP-Ras /kinetics/chain/kinetics[10]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ras/GAP* /kinetics/chain/kinetics[10]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/GAP /kinetics/chain/kinetics[10]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[10]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[10]/Ras/dephosph-GAP /kinetics/chain/kinetics[10]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/GAP*/diff /kinetics/chain/kinetics[10]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[10]/Ras/GAP*/diff /kinetics/chain/kinetics[10]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/GAP* /kinetics/chain/kinetics[10]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/GAP* /kinetics/chain/kinetics[10]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[10]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[10]/Ras/dephosph-GAP /kinetics/chain/kinetics[10]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[10]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[10]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[9]/Ras/GAP/diff /kinetics/chain/kinetics[10]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[10]/Ras/GAP/diff /kinetics/chain/kinetics[10]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/GTP-Ras /kinetics/chain/kinetics[10]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/GAP /kinetics/chain/kinetics[10]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[10]/Ras/GAP /kinetics/chain/kinetics[10]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/GAP /kinetics/chain/kinetics[10]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF /kinetics/chain/kinetics[10]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/CaM-GEF /kinetics/chain/kinetics[10]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca4 /kinetics/chain/kinetics[10]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[10]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[10]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[10]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[9]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[10]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[10]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[10]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/GDP-Ras /kinetics/chain/kinetics[10]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/CaM-GEF /kinetics/chain/kinetics[10]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[10]/Ras/CaM-GEF /kinetics/chain/kinetics[10]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/CaM-GEF /kinetics/chain/kinetics[10]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[10]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM/diff /kinetics/chain/kinetics[10]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[10]/CaM/CaM/diff /kinetics/chain/kinetics[10]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM /kinetics/chain/kinetics[10]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM /kinetics/chain/kinetics[10]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca3 /kinetics/chain/kinetics[10]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca4 /kinetics/chain/kinetics[10]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[10]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[10]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca3 /kinetics/chain/kinetics[10]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca3 /kinetics/chain/kinetics[10]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[10]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[10]/PKM/trigger_PKM /kinetics/chain/kinetics[10]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[10]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[10]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca4 /kinetics/chain/kinetics[10]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca4 /kinetics/chain/kinetics[10]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/CaM/CaM /kinetics/chain/kinetics[10]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca /kinetics/chain/kinetics[10]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ca /kinetics/chain/kinetics[10]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[10]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[10]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca2 /kinetics/chain/kinetics[10]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca2 /kinetics/chain/kinetics[10]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca3 /kinetics/chain/kinetics[10]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca2 /kinetics/chain/kinetics[10]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca2 /kinetics/chain/kinetics[10]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[10]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[10]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[10]/Ca REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[10]/Ca REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[10]/Ca REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[10]/Ca REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[10]/Ca REAC A B addmsg /kinetics/chain/kinetics[10]/Ca_diff /kinetics/chain/kinetics[10]/Ca REAC B A addmsg /kinetics/chain/kinetics[9]/Ca/diff /kinetics/chain/kinetics[10]/Ca REAC B A addmsg /kinetics/chain/kinetics[10]/Ca/diff /kinetics/chain/kinetics[10]/Ca REAC A B addmsg /kinetics/chain/kinetics[10]/Ca /kinetics/chain/kinetics[10]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ca /kinetics/chain/kinetics[10]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1 /kinetics/chain/kinetics[10]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[10]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ras/GTP-Ras /kinetics/chain/kinetics[10]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKM/trigger_PKM /kinetics/chain/kinetics[10]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[9]/PKM/Ca_detector/diff /kinetics/chain/kinetics[10]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[10]/PKM/Ca_detector/diff /kinetics/chain/kinetics[10]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[10]/PKM/Ca_detector /kinetics/chain/kinetics[10]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKM/Ca_detector /kinetics/chain/kinetics[10]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[10]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[10]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[10]/PKM/turn_off_activator /kinetics/chain/kinetics[10]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[9]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[10]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[10]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[10]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[10]/PKM/PKM_synthesis /kinetics/chain/kinetics[10]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[10]/PKM/AA_pool /kinetics/chain/kinetics[10]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKM/PKM_synthesis /kinetics/chain/kinetics[10]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKM/PKM_synthesis /kinetics/chain/kinetics[10]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[10]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[10]/PKC/PKM-zeta /kinetics/chain/kinetics[10]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKM/degraded_PKM /kinetics/chain/kinetics[10]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKM/PKM_degradation /kinetics/chain/kinetics[10]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[10]/PKM/trigger_PKM /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[9]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[10]/PKM/PKM_activator /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[10]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[10]/PKM/turn_off_activator /kinetics/chain/kinetics[10]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[9]/PKM/PKM_activator/diff /kinetics/chain/kinetics[10]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[10]/PKM/PKM_activator/diff /kinetics/chain/kinetics[10]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[10]/PKM/PKM_activator /kinetics/chain/kinetics[10]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKM/PKM_activator /kinetics/chain/kinetics[10]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKM/PKM_synthesis /kinetics/chain/kinetics[10]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKM/PKM_activator /kinetics/chain/kinetics[10]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca4 /kinetics/chain/kinetics[10]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKM/Ca_detector /kinetics/chain/kinetics[10]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex /kinetics/chain/kinetics[10]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ca_diff /kinetics/chain/kinetics[10]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[10]/Ca /kinetics/chain/kinetics[10]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ca_input /kinetics/chain/kinetics[10]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[11]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[11]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[11]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[11]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[11]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca /kinetics/chain/kinetics[11]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca /kinetics/chain/kinetics[11]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ca /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca /kinetics/chain/kinetics[11]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[11]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[11]/DAG /kinetics/chain/kinetics[11]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca /kinetics/chain/kinetics[11]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[11]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[11]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[11]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/DAG /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG /kinetics/chain/kinetics[11]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[11]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[11]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG /kinetics/chain/kinetics[11]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG /kinetics/chain/kinetics[11]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[11]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[11]/PKM/PKM_degradation /kinetics/chain/kinetics[11]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[11]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[11]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKM-zeta /kinetics/chain/kinetics[11]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKM-zeta /kinetics/chain/kinetics[11]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[11]/DAG REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG /kinetics/chain/kinetics[11]/DAG REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[11]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[11]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[11]/PKC/PKM-zeta /kinetics/chain/kinetics[11]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[11]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[11]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[11]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[11]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[11]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[11]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[11]/PKC-active /kinetics/chain/kinetics[11]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1 /kinetics/chain/kinetics[11]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC-active /kinetics/chain/kinetics[11]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[11]/Ras/GAP /kinetics/chain/kinetics[11]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC-active /kinetics/chain/kinetics[11]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF /kinetics/chain/kinetics[11]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[11]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[11]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[11]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[10]/MAPK*/diff /kinetics/chain/kinetics[11]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[11]/MAPK*/diff /kinetics/chain/kinetics[11]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[11]/MAPK* /kinetics/chain/kinetics[11]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1* /kinetics/chain/kinetics[11]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK* /kinetics/chain/kinetics[11]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK* /kinetics/chain/kinetics[11]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[11]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[11]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[11]/Ras-act-unphosph-raf /kinetics/chain/kinetics[11]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1/diff /kinetics/chain/kinetics[11]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1/diff /kinetics/chain/kinetics[11]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1 /kinetics/chain/kinetics[11]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1 /kinetics/chain/kinetics[11]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[11]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[11]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[11]/Ras-act-craf /kinetics/chain/kinetics[11]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[11]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[11]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1*/diff /kinetics/chain/kinetics[11]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1*/diff /kinetics/chain/kinetics[11]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1* /kinetics/chain/kinetics[11]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1* /kinetics/chain/kinetics[11]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[11]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[11]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[11]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK/diff /kinetics/chain/kinetics[11]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK/diff /kinetics/chain/kinetics[11]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK /kinetics/chain/kinetics[11]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK /kinetics/chain/kinetics[11]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[11]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[11]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[11]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK/diff /kinetics/chain/kinetics[11]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK/diff /kinetics/chain/kinetics[11]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK /kinetics/chain/kinetics[11]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK /kinetics/chain/kinetics[11]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[11]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[11]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1**/diff /kinetics/chain/kinetics[11]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1**/diff /kinetics/chain/kinetics[11]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1** /kinetics/chain/kinetics[11]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1** /kinetics/chain/kinetics[11]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[11]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[11]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[11]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[11]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[11]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[11]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[11]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[11]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[11]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK* /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK* /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK* /kinetics/chain/kinetics[11]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK* /kinetics/chain/kinetics[11]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[11]/Ras-act-unphosph-raf /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[11]/Ras-act-craf /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[11]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[11]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[11]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[10]/MKP-1/diff /kinetics/chain/kinetics[11]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[11]/MKP-1/diff /kinetics/chain/kinetics[11]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr /kinetics/chain/kinetics[11]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MKP-1 /kinetics/chain/kinetics[11]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK* /kinetics/chain/kinetics[11]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MKP-1 /kinetics/chain/kinetics[11]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[11]/MKP-1 /kinetics/chain/kinetics[11]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MKP-1 /kinetics/chain/kinetics[11]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1* /kinetics/chain/kinetics[11]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[11]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ras/GTP-Ras /kinetics/chain/kinetics[11]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[11]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[11]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[11]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[11]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/diff /kinetics/chain/kinetics[11]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/diff /kinetics/chain/kinetics[11]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1* /kinetics/chain/kinetics[11]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A /kinetics/chain/kinetics[11]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK* /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1** /kinetics/chain/kinetics[11]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A /kinetics/chain/kinetics[11]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A /kinetics/chain/kinetics[11]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A /kinetics/chain/kinetics[11]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF /kinetics/chain/kinetics[11]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ras/GEF* /kinetics/chain/kinetics[11]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[11]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[11]/Ras/dephosph-GEF /kinetics/chain/kinetics[11]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[11]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[11]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[11]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF/diff /kinetics/chain/kinetics[11]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF/diff /kinetics/chain/kinetics[11]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF /kinetics/chain/kinetics[11]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[11]/Ras/GDP-Ras /kinetics/chain/kinetics[11]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF /kinetics/chain/kinetics[11]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF /kinetics/chain/kinetics[11]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[11]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[11]/Ras/dephosph-GEF /kinetics/chain/kinetics[11]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[11]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[10]/Ras/GEF*/diff /kinetics/chain/kinetics[11]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[11]/Ras/GEF*/diff /kinetics/chain/kinetics[11]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/GEF* /kinetics/chain/kinetics[11]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[11]/Ras/GDP-Ras /kinetics/chain/kinetics[11]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/GEF* /kinetics/chain/kinetics[11]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/GEF* /kinetics/chain/kinetics[11]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ras-act-craf /kinetics/chain/kinetics[11]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[11]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[11]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[11]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[11]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[11]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[11]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[11]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[11]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[11]/Ras-act-unphosph-raf /kinetics/chain/kinetics[11]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[11]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[11]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[11]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/GTP-Ras /kinetics/chain/kinetics[11]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/GTP-Ras /kinetics/chain/kinetics[11]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[11]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[11]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[11]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[11]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[11]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[11]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[11]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[11]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[11]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[10]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[11]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[11]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[11]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/GDP-Ras /kinetics/chain/kinetics[11]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/GDP-Ras /kinetics/chain/kinetics[11]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ras/GTP-Ras /kinetics/chain/kinetics[11]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/GDP-Ras /kinetics/chain/kinetics[11]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ras/GAP* /kinetics/chain/kinetics[11]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/GAP /kinetics/chain/kinetics[11]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[11]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[11]/Ras/dephosph-GAP /kinetics/chain/kinetics[11]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/GAP*/diff /kinetics/chain/kinetics[11]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[11]/Ras/GAP*/diff /kinetics/chain/kinetics[11]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/GAP* /kinetics/chain/kinetics[11]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/GAP* /kinetics/chain/kinetics[11]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[11]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[11]/Ras/dephosph-GAP /kinetics/chain/kinetics[11]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[11]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[11]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[10]/Ras/GAP/diff /kinetics/chain/kinetics[11]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[11]/Ras/GAP/diff /kinetics/chain/kinetics[11]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/GTP-Ras /kinetics/chain/kinetics[11]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/GAP /kinetics/chain/kinetics[11]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[11]/Ras/GAP /kinetics/chain/kinetics[11]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/GAP /kinetics/chain/kinetics[11]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF /kinetics/chain/kinetics[11]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/CaM-GEF /kinetics/chain/kinetics[11]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca4 /kinetics/chain/kinetics[11]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[11]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[11]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[11]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[10]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[11]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[11]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[11]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/GDP-Ras /kinetics/chain/kinetics[11]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/CaM-GEF /kinetics/chain/kinetics[11]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[11]/Ras/CaM-GEF /kinetics/chain/kinetics[11]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/CaM-GEF /kinetics/chain/kinetics[11]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[11]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM/diff /kinetics/chain/kinetics[11]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[11]/CaM/CaM/diff /kinetics/chain/kinetics[11]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM /kinetics/chain/kinetics[11]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM /kinetics/chain/kinetics[11]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca3 /kinetics/chain/kinetics[11]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca4 /kinetics/chain/kinetics[11]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[11]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[11]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca3 /kinetics/chain/kinetics[11]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca3 /kinetics/chain/kinetics[11]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[11]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[11]/PKM/trigger_PKM /kinetics/chain/kinetics[11]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[11]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[11]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca4 /kinetics/chain/kinetics[11]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 /kinetics/chain/kinetics[11]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/CaM/CaM /kinetics/chain/kinetics[11]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca /kinetics/chain/kinetics[11]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ca /kinetics/chain/kinetics[11]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[11]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[11]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca2 /kinetics/chain/kinetics[11]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca2 /kinetics/chain/kinetics[11]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca3 /kinetics/chain/kinetics[11]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca2 /kinetics/chain/kinetics[11]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca2 /kinetics/chain/kinetics[11]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[11]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[11]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[11]/Ca REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[11]/Ca REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[11]/Ca REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[11]/Ca REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[11]/Ca REAC A B addmsg /kinetics/chain/kinetics[11]/Ca_diff /kinetics/chain/kinetics[11]/Ca REAC B A addmsg /kinetics/chain/kinetics[10]/Ca/diff /kinetics/chain/kinetics[11]/Ca REAC B A addmsg /kinetics/chain/kinetics[11]/Ca/diff /kinetics/chain/kinetics[11]/Ca REAC A B addmsg /kinetics/chain/kinetics[11]/Ca /kinetics/chain/kinetics[11]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ca /kinetics/chain/kinetics[11]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1 /kinetics/chain/kinetics[11]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[11]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ras/GTP-Ras /kinetics/chain/kinetics[11]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKM/trigger_PKM /kinetics/chain/kinetics[11]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[10]/PKM/Ca_detector/diff /kinetics/chain/kinetics[11]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[11]/PKM/Ca_detector/diff /kinetics/chain/kinetics[11]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[11]/PKM/Ca_detector /kinetics/chain/kinetics[11]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKM/Ca_detector /kinetics/chain/kinetics[11]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[11]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[11]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[11]/PKM/turn_off_activator /kinetics/chain/kinetics[11]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[10]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[11]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[11]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[11]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[11]/PKM/PKM_synthesis /kinetics/chain/kinetics[11]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[11]/PKM/AA_pool /kinetics/chain/kinetics[11]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKM/PKM_synthesis /kinetics/chain/kinetics[11]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKM/PKM_synthesis /kinetics/chain/kinetics[11]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[11]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[11]/PKC/PKM-zeta /kinetics/chain/kinetics[11]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKM/degraded_PKM /kinetics/chain/kinetics[11]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKM/PKM_degradation /kinetics/chain/kinetics[11]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[11]/PKM/trigger_PKM /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[10]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[11]/PKM/PKM_activator /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[11]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[11]/PKM/turn_off_activator /kinetics/chain/kinetics[11]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[10]/PKM/PKM_activator/diff /kinetics/chain/kinetics[11]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[11]/PKM/PKM_activator/diff /kinetics/chain/kinetics[11]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[11]/PKM/PKM_activator /kinetics/chain/kinetics[11]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKM/PKM_activator /kinetics/chain/kinetics[11]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKM/PKM_synthesis /kinetics/chain/kinetics[11]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKM/PKM_activator /kinetics/chain/kinetics[11]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca4 /kinetics/chain/kinetics[11]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKM/Ca_detector /kinetics/chain/kinetics[11]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex /kinetics/chain/kinetics[11]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ca_diff /kinetics/chain/kinetics[11]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[11]/Ca /kinetics/chain/kinetics[11]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ca_input /kinetics/chain/kinetics[11]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[12]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[12]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[12]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[12]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[12]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca /kinetics/chain/kinetics[12]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca /kinetics/chain/kinetics[12]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ca /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca /kinetics/chain/kinetics[12]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[12]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[12]/DAG /kinetics/chain/kinetics[12]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca /kinetics/chain/kinetics[12]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[12]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[12]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[12]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/DAG /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG /kinetics/chain/kinetics[12]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[12]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[12]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG /kinetics/chain/kinetics[12]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG /kinetics/chain/kinetics[12]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[12]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[12]/PKM/PKM_degradation /kinetics/chain/kinetics[12]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[12]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[12]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKM-zeta /kinetics/chain/kinetics[12]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKM-zeta /kinetics/chain/kinetics[12]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[12]/DAG REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG /kinetics/chain/kinetics[12]/DAG REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[12]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[12]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[12]/PKC/PKM-zeta /kinetics/chain/kinetics[12]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[12]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[12]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[12]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[12]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[12]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[12]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[12]/PKC-active /kinetics/chain/kinetics[12]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1 /kinetics/chain/kinetics[12]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC-active /kinetics/chain/kinetics[12]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[12]/Ras/GAP /kinetics/chain/kinetics[12]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC-active /kinetics/chain/kinetics[12]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF /kinetics/chain/kinetics[12]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[12]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[12]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[12]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[11]/MAPK*/diff /kinetics/chain/kinetics[12]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[12]/MAPK*/diff /kinetics/chain/kinetics[12]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[12]/MAPK* /kinetics/chain/kinetics[12]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1* /kinetics/chain/kinetics[12]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK* /kinetics/chain/kinetics[12]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK* /kinetics/chain/kinetics[12]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[12]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[12]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[12]/Ras-act-unphosph-raf /kinetics/chain/kinetics[12]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1/diff /kinetics/chain/kinetics[12]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1/diff /kinetics/chain/kinetics[12]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1 /kinetics/chain/kinetics[12]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1 /kinetics/chain/kinetics[12]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[12]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[12]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[12]/Ras-act-craf /kinetics/chain/kinetics[12]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[12]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[12]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1*/diff /kinetics/chain/kinetics[12]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1*/diff /kinetics/chain/kinetics[12]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1* /kinetics/chain/kinetics[12]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1* /kinetics/chain/kinetics[12]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[12]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[12]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[12]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK/diff /kinetics/chain/kinetics[12]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK/diff /kinetics/chain/kinetics[12]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK /kinetics/chain/kinetics[12]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK /kinetics/chain/kinetics[12]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[12]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[12]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[12]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK/diff /kinetics/chain/kinetics[12]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK/diff /kinetics/chain/kinetics[12]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK /kinetics/chain/kinetics[12]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK /kinetics/chain/kinetics[12]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[12]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[12]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1**/diff /kinetics/chain/kinetics[12]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1**/diff /kinetics/chain/kinetics[12]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1** /kinetics/chain/kinetics[12]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1** /kinetics/chain/kinetics[12]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[12]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[12]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[12]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[12]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[12]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[12]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[12]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[12]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[12]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK* /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK* /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK* /kinetics/chain/kinetics[12]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK* /kinetics/chain/kinetics[12]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[12]/Ras-act-unphosph-raf /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[12]/Ras-act-craf /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[12]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[12]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[12]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[11]/MKP-1/diff /kinetics/chain/kinetics[12]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[12]/MKP-1/diff /kinetics/chain/kinetics[12]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr /kinetics/chain/kinetics[12]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MKP-1 /kinetics/chain/kinetics[12]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK* /kinetics/chain/kinetics[12]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MKP-1 /kinetics/chain/kinetics[12]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[12]/MKP-1 /kinetics/chain/kinetics[12]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MKP-1 /kinetics/chain/kinetics[12]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1* /kinetics/chain/kinetics[12]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[12]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ras/GTP-Ras /kinetics/chain/kinetics[12]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[12]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[12]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[12]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[12]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/diff /kinetics/chain/kinetics[12]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/diff /kinetics/chain/kinetics[12]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1* /kinetics/chain/kinetics[12]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A /kinetics/chain/kinetics[12]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK* /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1** /kinetics/chain/kinetics[12]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A /kinetics/chain/kinetics[12]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A /kinetics/chain/kinetics[12]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A /kinetics/chain/kinetics[12]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF /kinetics/chain/kinetics[12]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ras/GEF* /kinetics/chain/kinetics[12]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[12]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[12]/Ras/dephosph-GEF /kinetics/chain/kinetics[12]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[12]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[12]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[12]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF/diff /kinetics/chain/kinetics[12]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF/diff /kinetics/chain/kinetics[12]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF /kinetics/chain/kinetics[12]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[12]/Ras/GDP-Ras /kinetics/chain/kinetics[12]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF /kinetics/chain/kinetics[12]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF /kinetics/chain/kinetics[12]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[12]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[12]/Ras/dephosph-GEF /kinetics/chain/kinetics[12]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[12]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[11]/Ras/GEF*/diff /kinetics/chain/kinetics[12]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[12]/Ras/GEF*/diff /kinetics/chain/kinetics[12]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/GEF* /kinetics/chain/kinetics[12]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[12]/Ras/GDP-Ras /kinetics/chain/kinetics[12]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/GEF* /kinetics/chain/kinetics[12]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/GEF* /kinetics/chain/kinetics[12]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ras-act-craf /kinetics/chain/kinetics[12]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[12]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[12]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[12]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[12]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[12]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[12]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[12]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[12]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[12]/Ras-act-unphosph-raf /kinetics/chain/kinetics[12]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[12]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[12]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[12]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/GTP-Ras /kinetics/chain/kinetics[12]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/GTP-Ras /kinetics/chain/kinetics[12]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[12]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[12]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[12]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[12]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[12]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[12]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[12]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[12]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[12]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[11]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[12]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[12]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[12]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/GDP-Ras /kinetics/chain/kinetics[12]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/GDP-Ras /kinetics/chain/kinetics[12]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ras/GTP-Ras /kinetics/chain/kinetics[12]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/GDP-Ras /kinetics/chain/kinetics[12]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ras/GAP* /kinetics/chain/kinetics[12]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/GAP /kinetics/chain/kinetics[12]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[12]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[12]/Ras/dephosph-GAP /kinetics/chain/kinetics[12]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/GAP*/diff /kinetics/chain/kinetics[12]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[12]/Ras/GAP*/diff /kinetics/chain/kinetics[12]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/GAP* /kinetics/chain/kinetics[12]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/GAP* /kinetics/chain/kinetics[12]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[12]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[12]/Ras/dephosph-GAP /kinetics/chain/kinetics[12]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[12]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[12]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[11]/Ras/GAP/diff /kinetics/chain/kinetics[12]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[12]/Ras/GAP/diff /kinetics/chain/kinetics[12]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/GTP-Ras /kinetics/chain/kinetics[12]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/GAP /kinetics/chain/kinetics[12]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[12]/Ras/GAP /kinetics/chain/kinetics[12]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/GAP /kinetics/chain/kinetics[12]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF /kinetics/chain/kinetics[12]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/CaM-GEF /kinetics/chain/kinetics[12]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 /kinetics/chain/kinetics[12]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[12]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[12]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[12]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[11]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[12]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[12]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[12]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/GDP-Ras /kinetics/chain/kinetics[12]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/CaM-GEF /kinetics/chain/kinetics[12]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[12]/Ras/CaM-GEF /kinetics/chain/kinetics[12]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/CaM-GEF /kinetics/chain/kinetics[12]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[12]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM/diff /kinetics/chain/kinetics[12]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[12]/CaM/CaM/diff /kinetics/chain/kinetics[12]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM /kinetics/chain/kinetics[12]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM /kinetics/chain/kinetics[12]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca3 /kinetics/chain/kinetics[12]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 /kinetics/chain/kinetics[12]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[12]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[12]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca3 /kinetics/chain/kinetics[12]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca3 /kinetics/chain/kinetics[12]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[12]/PKM/trigger_PKM /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 /kinetics/chain/kinetics[12]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca4 /kinetics/chain/kinetics[12]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/CaM/CaM /kinetics/chain/kinetics[12]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca /kinetics/chain/kinetics[12]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ca /kinetics/chain/kinetics[12]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[12]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[12]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca2 /kinetics/chain/kinetics[12]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca2 /kinetics/chain/kinetics[12]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca3 /kinetics/chain/kinetics[12]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca2 /kinetics/chain/kinetics[12]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca2 /kinetics/chain/kinetics[12]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[12]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[12]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[12]/Ca REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[12]/Ca REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[12]/Ca REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[12]/Ca REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[12]/Ca REAC A B addmsg /kinetics/chain/kinetics[12]/Ca_diff /kinetics/chain/kinetics[12]/Ca REAC B A addmsg /kinetics/chain/kinetics[11]/Ca/diff /kinetics/chain/kinetics[12]/Ca REAC B A addmsg /kinetics/chain/kinetics[12]/Ca/diff /kinetics/chain/kinetics[12]/Ca REAC A B addmsg /kinetics/chain/kinetics[12]/Ca /kinetics/chain/kinetics[12]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ca /kinetics/chain/kinetics[12]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1 /kinetics/chain/kinetics[12]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[12]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ras/GTP-Ras /kinetics/chain/kinetics[12]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKM/trigger_PKM /kinetics/chain/kinetics[12]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[11]/PKM/Ca_detector/diff /kinetics/chain/kinetics[12]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[12]/PKM/Ca_detector/diff /kinetics/chain/kinetics[12]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[12]/PKM/Ca_detector /kinetics/chain/kinetics[12]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKM/Ca_detector /kinetics/chain/kinetics[12]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[12]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[12]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[12]/PKM/turn_off_activator /kinetics/chain/kinetics[12]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[11]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[12]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[12]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[12]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[12]/PKM/PKM_synthesis /kinetics/chain/kinetics[12]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[12]/PKM/AA_pool /kinetics/chain/kinetics[12]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKM/PKM_synthesis /kinetics/chain/kinetics[12]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKM/PKM_synthesis /kinetics/chain/kinetics[12]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[12]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[12]/PKC/PKM-zeta /kinetics/chain/kinetics[12]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKM/degraded_PKM /kinetics/chain/kinetics[12]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKM/PKM_degradation /kinetics/chain/kinetics[12]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[12]/PKM/trigger_PKM /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[11]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[12]/PKM/PKM_activator /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[12]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[12]/PKM/turn_off_activator /kinetics/chain/kinetics[12]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[11]/PKM/PKM_activator/diff /kinetics/chain/kinetics[12]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[12]/PKM/PKM_activator/diff /kinetics/chain/kinetics[12]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[12]/PKM/PKM_activator /kinetics/chain/kinetics[12]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKM/PKM_activator /kinetics/chain/kinetics[12]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKM/PKM_synthesis /kinetics/chain/kinetics[12]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKM/PKM_activator /kinetics/chain/kinetics[12]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 /kinetics/chain/kinetics[12]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKM/Ca_detector /kinetics/chain/kinetics[12]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex /kinetics/chain/kinetics[12]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ca_diff /kinetics/chain/kinetics[12]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[12]/Ca /kinetics/chain/kinetics[12]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ca_input /kinetics/chain/kinetics[12]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[13]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[13]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[13]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[13]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[13]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca /kinetics/chain/kinetics[13]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca /kinetics/chain/kinetics[13]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ca /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca /kinetics/chain/kinetics[13]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[13]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[13]/DAG /kinetics/chain/kinetics[13]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca /kinetics/chain/kinetics[13]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[13]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[13]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[13]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/DAG /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG /kinetics/chain/kinetics[13]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[13]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[13]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG /kinetics/chain/kinetics[13]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG /kinetics/chain/kinetics[13]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[13]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[13]/PKM/PKM_degradation /kinetics/chain/kinetics[13]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[13]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[13]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKM-zeta /kinetics/chain/kinetics[13]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKM-zeta /kinetics/chain/kinetics[13]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[13]/DAG REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG /kinetics/chain/kinetics[13]/DAG REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[13]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[13]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[13]/PKC/PKM-zeta /kinetics/chain/kinetics[13]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[13]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[13]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[13]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[13]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[13]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[13]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[13]/PKC-active /kinetics/chain/kinetics[13]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1 /kinetics/chain/kinetics[13]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC-active /kinetics/chain/kinetics[13]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[13]/Ras/GAP /kinetics/chain/kinetics[13]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC-active /kinetics/chain/kinetics[13]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF /kinetics/chain/kinetics[13]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[13]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[13]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[13]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[12]/MAPK*/diff /kinetics/chain/kinetics[13]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[13]/MAPK*/diff /kinetics/chain/kinetics[13]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[13]/MAPK* /kinetics/chain/kinetics[13]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1* /kinetics/chain/kinetics[13]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK* /kinetics/chain/kinetics[13]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK* /kinetics/chain/kinetics[13]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[13]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[13]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[13]/Ras-act-unphosph-raf /kinetics/chain/kinetics[13]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1/diff /kinetics/chain/kinetics[13]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1/diff /kinetics/chain/kinetics[13]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1 /kinetics/chain/kinetics[13]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1 /kinetics/chain/kinetics[13]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[13]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[13]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[13]/Ras-act-craf /kinetics/chain/kinetics[13]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[13]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[13]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1*/diff /kinetics/chain/kinetics[13]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1*/diff /kinetics/chain/kinetics[13]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1* /kinetics/chain/kinetics[13]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1* /kinetics/chain/kinetics[13]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[13]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[13]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[13]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK/diff /kinetics/chain/kinetics[13]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK/diff /kinetics/chain/kinetics[13]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK /kinetics/chain/kinetics[13]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK /kinetics/chain/kinetics[13]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[13]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[13]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[13]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK/diff /kinetics/chain/kinetics[13]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK/diff /kinetics/chain/kinetics[13]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK /kinetics/chain/kinetics[13]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK /kinetics/chain/kinetics[13]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[13]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[13]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1**/diff /kinetics/chain/kinetics[13]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1**/diff /kinetics/chain/kinetics[13]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1** /kinetics/chain/kinetics[13]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1** /kinetics/chain/kinetics[13]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[13]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[13]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[13]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[13]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[13]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[13]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[13]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[13]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[13]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK* /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK* /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK* /kinetics/chain/kinetics[13]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK* /kinetics/chain/kinetics[13]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[13]/Ras-act-unphosph-raf /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[13]/Ras-act-craf /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[13]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[13]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[13]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[12]/MKP-1/diff /kinetics/chain/kinetics[13]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[13]/MKP-1/diff /kinetics/chain/kinetics[13]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr /kinetics/chain/kinetics[13]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MKP-1 /kinetics/chain/kinetics[13]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK* /kinetics/chain/kinetics[13]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MKP-1 /kinetics/chain/kinetics[13]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[13]/MKP-1 /kinetics/chain/kinetics[13]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MKP-1 /kinetics/chain/kinetics[13]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1* /kinetics/chain/kinetics[13]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[13]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ras/GTP-Ras /kinetics/chain/kinetics[13]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[13]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[13]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[13]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[13]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/diff /kinetics/chain/kinetics[13]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/diff /kinetics/chain/kinetics[13]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1* /kinetics/chain/kinetics[13]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A /kinetics/chain/kinetics[13]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK* /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1** /kinetics/chain/kinetics[13]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A /kinetics/chain/kinetics[13]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A /kinetics/chain/kinetics[13]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A /kinetics/chain/kinetics[13]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF /kinetics/chain/kinetics[13]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ras/GEF* /kinetics/chain/kinetics[13]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[13]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[13]/Ras/dephosph-GEF /kinetics/chain/kinetics[13]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[13]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[13]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[13]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF/diff /kinetics/chain/kinetics[13]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF/diff /kinetics/chain/kinetics[13]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF /kinetics/chain/kinetics[13]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[13]/Ras/GDP-Ras /kinetics/chain/kinetics[13]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF /kinetics/chain/kinetics[13]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF /kinetics/chain/kinetics[13]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[13]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[13]/Ras/dephosph-GEF /kinetics/chain/kinetics[13]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[13]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[12]/Ras/GEF*/diff /kinetics/chain/kinetics[13]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[13]/Ras/GEF*/diff /kinetics/chain/kinetics[13]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/GEF* /kinetics/chain/kinetics[13]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[13]/Ras/GDP-Ras /kinetics/chain/kinetics[13]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/GEF* /kinetics/chain/kinetics[13]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/GEF* /kinetics/chain/kinetics[13]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ras-act-craf /kinetics/chain/kinetics[13]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[13]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[13]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[13]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[13]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[13]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[13]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[13]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[13]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[13]/Ras-act-unphosph-raf /kinetics/chain/kinetics[13]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[13]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[13]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[13]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/GTP-Ras /kinetics/chain/kinetics[13]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/GTP-Ras /kinetics/chain/kinetics[13]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[13]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[13]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[13]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[13]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[13]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[13]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[13]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[13]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[13]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[12]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[13]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[13]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[13]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/GDP-Ras /kinetics/chain/kinetics[13]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/GDP-Ras /kinetics/chain/kinetics[13]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ras/GTP-Ras /kinetics/chain/kinetics[13]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/GDP-Ras /kinetics/chain/kinetics[13]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ras/GAP* /kinetics/chain/kinetics[13]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/GAP /kinetics/chain/kinetics[13]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[13]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[13]/Ras/dephosph-GAP /kinetics/chain/kinetics[13]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/GAP*/diff /kinetics/chain/kinetics[13]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[13]/Ras/GAP*/diff /kinetics/chain/kinetics[13]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/GAP* /kinetics/chain/kinetics[13]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/GAP* /kinetics/chain/kinetics[13]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[13]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[13]/Ras/dephosph-GAP /kinetics/chain/kinetics[13]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[13]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[13]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[12]/Ras/GAP/diff /kinetics/chain/kinetics[13]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[13]/Ras/GAP/diff /kinetics/chain/kinetics[13]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/GTP-Ras /kinetics/chain/kinetics[13]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/GAP /kinetics/chain/kinetics[13]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[13]/Ras/GAP /kinetics/chain/kinetics[13]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/GAP /kinetics/chain/kinetics[13]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF /kinetics/chain/kinetics[13]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/CaM-GEF /kinetics/chain/kinetics[13]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca4 /kinetics/chain/kinetics[13]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[13]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[13]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[13]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[12]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[13]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[13]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[13]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/GDP-Ras /kinetics/chain/kinetics[13]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/CaM-GEF /kinetics/chain/kinetics[13]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[13]/Ras/CaM-GEF /kinetics/chain/kinetics[13]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/CaM-GEF /kinetics/chain/kinetics[13]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[13]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM/diff /kinetics/chain/kinetics[13]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[13]/CaM/CaM/diff /kinetics/chain/kinetics[13]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM /kinetics/chain/kinetics[13]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM /kinetics/chain/kinetics[13]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca3 /kinetics/chain/kinetics[13]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca4 /kinetics/chain/kinetics[13]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[13]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[13]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca3 /kinetics/chain/kinetics[13]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca3 /kinetics/chain/kinetics[13]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[13]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[13]/PKM/trigger_PKM /kinetics/chain/kinetics[13]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[13]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[13]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca4 /kinetics/chain/kinetics[13]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 /kinetics/chain/kinetics[13]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/CaM/CaM /kinetics/chain/kinetics[13]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca /kinetics/chain/kinetics[13]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ca /kinetics/chain/kinetics[13]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[13]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[13]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca2 /kinetics/chain/kinetics[13]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca2 /kinetics/chain/kinetics[13]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca3 /kinetics/chain/kinetics[13]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca2 /kinetics/chain/kinetics[13]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca2 /kinetics/chain/kinetics[13]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[13]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[13]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[13]/Ca REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[13]/Ca REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[13]/Ca REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[13]/Ca REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[13]/Ca REAC A B addmsg /kinetics/chain/kinetics[13]/Ca_diff /kinetics/chain/kinetics[13]/Ca REAC B A addmsg /kinetics/chain/kinetics[12]/Ca/diff /kinetics/chain/kinetics[13]/Ca REAC B A addmsg /kinetics/chain/kinetics[13]/Ca/diff /kinetics/chain/kinetics[13]/Ca REAC A B addmsg /kinetics/chain/kinetics[13]/Ca /kinetics/chain/kinetics[13]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ca /kinetics/chain/kinetics[13]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1 /kinetics/chain/kinetics[13]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[13]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ras/GTP-Ras /kinetics/chain/kinetics[13]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKM/trigger_PKM /kinetics/chain/kinetics[13]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[12]/PKM/Ca_detector/diff /kinetics/chain/kinetics[13]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[13]/PKM/Ca_detector/diff /kinetics/chain/kinetics[13]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[13]/PKM/Ca_detector /kinetics/chain/kinetics[13]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKM/Ca_detector /kinetics/chain/kinetics[13]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[13]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[13]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[13]/PKM/turn_off_activator /kinetics/chain/kinetics[13]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[12]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[13]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[13]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[13]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[13]/PKM/PKM_synthesis /kinetics/chain/kinetics[13]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[13]/PKM/AA_pool /kinetics/chain/kinetics[13]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKM/PKM_synthesis /kinetics/chain/kinetics[13]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKM/PKM_synthesis /kinetics/chain/kinetics[13]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[13]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[13]/PKC/PKM-zeta /kinetics/chain/kinetics[13]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKM/degraded_PKM /kinetics/chain/kinetics[13]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKM/PKM_degradation /kinetics/chain/kinetics[13]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[13]/PKM/trigger_PKM /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[12]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[13]/PKM/PKM_activator /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[13]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[13]/PKM/turn_off_activator /kinetics/chain/kinetics[13]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[12]/PKM/PKM_activator/diff /kinetics/chain/kinetics[13]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[13]/PKM/PKM_activator/diff /kinetics/chain/kinetics[13]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[13]/PKM/PKM_activator /kinetics/chain/kinetics[13]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKM/PKM_activator /kinetics/chain/kinetics[13]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKM/PKM_synthesis /kinetics/chain/kinetics[13]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKM/PKM_activator /kinetics/chain/kinetics[13]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca4 /kinetics/chain/kinetics[13]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKM/Ca_detector /kinetics/chain/kinetics[13]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex /kinetics/chain/kinetics[13]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ca_diff /kinetics/chain/kinetics[13]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[13]/Ca /kinetics/chain/kinetics[13]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ca_input /kinetics/chain/kinetics[13]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[14]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[14]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[14]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[14]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[14]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca /kinetics/chain/kinetics[14]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca /kinetics/chain/kinetics[14]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ca /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca /kinetics/chain/kinetics[14]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[14]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[14]/DAG /kinetics/chain/kinetics[14]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca /kinetics/chain/kinetics[14]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[14]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[14]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[14]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/DAG /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG /kinetics/chain/kinetics[14]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[14]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[14]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG /kinetics/chain/kinetics[14]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG /kinetics/chain/kinetics[14]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[14]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[14]/PKM/PKM_degradation /kinetics/chain/kinetics[14]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[14]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[14]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKM-zeta /kinetics/chain/kinetics[14]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKM-zeta /kinetics/chain/kinetics[14]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[14]/DAG REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG /kinetics/chain/kinetics[14]/DAG REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[14]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[14]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[14]/PKC/PKM-zeta /kinetics/chain/kinetics[14]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[14]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[14]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[14]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[14]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[14]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[14]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[14]/PKC-active /kinetics/chain/kinetics[14]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1 /kinetics/chain/kinetics[14]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC-active /kinetics/chain/kinetics[14]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[14]/Ras/GAP /kinetics/chain/kinetics[14]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC-active /kinetics/chain/kinetics[14]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF /kinetics/chain/kinetics[14]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[14]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[14]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[14]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[13]/MAPK*/diff /kinetics/chain/kinetics[14]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[14]/MAPK*/diff /kinetics/chain/kinetics[14]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[14]/MAPK* /kinetics/chain/kinetics[14]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1* /kinetics/chain/kinetics[14]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK* /kinetics/chain/kinetics[14]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK* /kinetics/chain/kinetics[14]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[14]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[14]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[14]/Ras-act-unphosph-raf /kinetics/chain/kinetics[14]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1/diff /kinetics/chain/kinetics[14]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1/diff /kinetics/chain/kinetics[14]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1 /kinetics/chain/kinetics[14]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1 /kinetics/chain/kinetics[14]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[14]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[14]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[14]/Ras-act-craf /kinetics/chain/kinetics[14]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[14]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[14]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1*/diff /kinetics/chain/kinetics[14]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1*/diff /kinetics/chain/kinetics[14]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1* /kinetics/chain/kinetics[14]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1* /kinetics/chain/kinetics[14]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[14]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[14]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[14]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK/diff /kinetics/chain/kinetics[14]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK/diff /kinetics/chain/kinetics[14]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK /kinetics/chain/kinetics[14]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK /kinetics/chain/kinetics[14]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[14]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[14]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[14]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK/diff /kinetics/chain/kinetics[14]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK/diff /kinetics/chain/kinetics[14]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK /kinetics/chain/kinetics[14]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK /kinetics/chain/kinetics[14]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[14]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[14]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1**/diff /kinetics/chain/kinetics[14]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1**/diff /kinetics/chain/kinetics[14]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1** /kinetics/chain/kinetics[14]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1** /kinetics/chain/kinetics[14]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[14]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[14]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[14]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[14]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[14]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[14]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[14]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[14]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[14]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK* /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK* /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK* /kinetics/chain/kinetics[14]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK* /kinetics/chain/kinetics[14]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[14]/Ras-act-unphosph-raf /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[14]/Ras-act-craf /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[14]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[14]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[14]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[13]/MKP-1/diff /kinetics/chain/kinetics[14]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[14]/MKP-1/diff /kinetics/chain/kinetics[14]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr /kinetics/chain/kinetics[14]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MKP-1 /kinetics/chain/kinetics[14]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK* /kinetics/chain/kinetics[14]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MKP-1 /kinetics/chain/kinetics[14]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[14]/MKP-1 /kinetics/chain/kinetics[14]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MKP-1 /kinetics/chain/kinetics[14]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1* /kinetics/chain/kinetics[14]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[14]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ras/GTP-Ras /kinetics/chain/kinetics[14]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[14]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[14]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[14]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[14]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/diff /kinetics/chain/kinetics[14]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/diff /kinetics/chain/kinetics[14]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1* /kinetics/chain/kinetics[14]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A /kinetics/chain/kinetics[14]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK* /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1** /kinetics/chain/kinetics[14]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A /kinetics/chain/kinetics[14]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A /kinetics/chain/kinetics[14]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A /kinetics/chain/kinetics[14]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF /kinetics/chain/kinetics[14]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ras/GEF* /kinetics/chain/kinetics[14]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[14]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[14]/Ras/dephosph-GEF /kinetics/chain/kinetics[14]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[14]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[14]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[14]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF/diff /kinetics/chain/kinetics[14]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF/diff /kinetics/chain/kinetics[14]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF /kinetics/chain/kinetics[14]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[14]/Ras/GDP-Ras /kinetics/chain/kinetics[14]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF /kinetics/chain/kinetics[14]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF /kinetics/chain/kinetics[14]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[14]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[14]/Ras/dephosph-GEF /kinetics/chain/kinetics[14]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[14]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[13]/Ras/GEF*/diff /kinetics/chain/kinetics[14]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[14]/Ras/GEF*/diff /kinetics/chain/kinetics[14]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/GEF* /kinetics/chain/kinetics[14]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[14]/Ras/GDP-Ras /kinetics/chain/kinetics[14]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/GEF* /kinetics/chain/kinetics[14]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/GEF* /kinetics/chain/kinetics[14]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ras-act-craf /kinetics/chain/kinetics[14]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[14]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[14]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[14]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[14]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[14]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[14]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[14]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[14]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[14]/Ras-act-unphosph-raf /kinetics/chain/kinetics[14]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[14]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[14]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[14]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/GTP-Ras /kinetics/chain/kinetics[14]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/GTP-Ras /kinetics/chain/kinetics[14]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[14]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[14]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[14]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[14]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[14]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[14]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[14]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[14]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[14]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[13]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[14]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[14]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[14]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/GDP-Ras /kinetics/chain/kinetics[14]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/GDP-Ras /kinetics/chain/kinetics[14]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ras/GTP-Ras /kinetics/chain/kinetics[14]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/GDP-Ras /kinetics/chain/kinetics[14]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ras/GAP* /kinetics/chain/kinetics[14]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/GAP /kinetics/chain/kinetics[14]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[14]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[14]/Ras/dephosph-GAP /kinetics/chain/kinetics[14]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/GAP*/diff /kinetics/chain/kinetics[14]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[14]/Ras/GAP*/diff /kinetics/chain/kinetics[14]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/GAP* /kinetics/chain/kinetics[14]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/GAP* /kinetics/chain/kinetics[14]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[14]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[14]/Ras/dephosph-GAP /kinetics/chain/kinetics[14]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[14]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[14]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[13]/Ras/GAP/diff /kinetics/chain/kinetics[14]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[14]/Ras/GAP/diff /kinetics/chain/kinetics[14]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/GTP-Ras /kinetics/chain/kinetics[14]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/GAP /kinetics/chain/kinetics[14]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[14]/Ras/GAP /kinetics/chain/kinetics[14]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/GAP /kinetics/chain/kinetics[14]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF /kinetics/chain/kinetics[14]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/CaM-GEF /kinetics/chain/kinetics[14]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 /kinetics/chain/kinetics[14]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[14]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[14]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[14]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[13]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[14]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[14]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[14]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/GDP-Ras /kinetics/chain/kinetics[14]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/CaM-GEF /kinetics/chain/kinetics[14]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[14]/Ras/CaM-GEF /kinetics/chain/kinetics[14]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/CaM-GEF /kinetics/chain/kinetics[14]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[14]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM/diff /kinetics/chain/kinetics[14]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[14]/CaM/CaM/diff /kinetics/chain/kinetics[14]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM /kinetics/chain/kinetics[14]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM /kinetics/chain/kinetics[14]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca3 /kinetics/chain/kinetics[14]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 /kinetics/chain/kinetics[14]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[14]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[14]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca3 /kinetics/chain/kinetics[14]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca3 /kinetics/chain/kinetics[14]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[14]/PKM/trigger_PKM /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 /kinetics/chain/kinetics[14]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca4 /kinetics/chain/kinetics[14]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/CaM/CaM /kinetics/chain/kinetics[14]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca /kinetics/chain/kinetics[14]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ca /kinetics/chain/kinetics[14]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[14]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[14]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca2 /kinetics/chain/kinetics[14]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca2 /kinetics/chain/kinetics[14]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca3 /kinetics/chain/kinetics[14]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca2 /kinetics/chain/kinetics[14]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca2 /kinetics/chain/kinetics[14]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[14]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[14]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[14]/Ca REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[14]/Ca REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[14]/Ca REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[14]/Ca REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[14]/Ca REAC A B addmsg /kinetics/chain/kinetics[14]/Ca_diff /kinetics/chain/kinetics[14]/Ca REAC B A addmsg /kinetics/chain/kinetics[13]/Ca/diff /kinetics/chain/kinetics[14]/Ca REAC B A addmsg /kinetics/chain/kinetics[14]/Ca/diff /kinetics/chain/kinetics[14]/Ca REAC A B addmsg /kinetics/chain/kinetics[14]/Ca /kinetics/chain/kinetics[14]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ca /kinetics/chain/kinetics[14]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1 /kinetics/chain/kinetics[14]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[14]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ras/GTP-Ras /kinetics/chain/kinetics[14]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKM/trigger_PKM /kinetics/chain/kinetics[14]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[13]/PKM/Ca_detector/diff /kinetics/chain/kinetics[14]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[14]/PKM/Ca_detector/diff /kinetics/chain/kinetics[14]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[14]/PKM/Ca_detector /kinetics/chain/kinetics[14]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKM/Ca_detector /kinetics/chain/kinetics[14]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[14]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[14]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[14]/PKM/turn_off_activator /kinetics/chain/kinetics[14]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[13]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[14]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[14]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[14]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[14]/PKM/PKM_synthesis /kinetics/chain/kinetics[14]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[14]/PKM/AA_pool /kinetics/chain/kinetics[14]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKM/PKM_synthesis /kinetics/chain/kinetics[14]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKM/PKM_synthesis /kinetics/chain/kinetics[14]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[14]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[14]/PKC/PKM-zeta /kinetics/chain/kinetics[14]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKM/degraded_PKM /kinetics/chain/kinetics[14]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKM/PKM_degradation /kinetics/chain/kinetics[14]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[14]/PKM/trigger_PKM /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[13]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[14]/PKM/PKM_activator /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[14]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[14]/PKM/turn_off_activator /kinetics/chain/kinetics[14]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[13]/PKM/PKM_activator/diff /kinetics/chain/kinetics[14]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[14]/PKM/PKM_activator/diff /kinetics/chain/kinetics[14]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[14]/PKM/PKM_activator /kinetics/chain/kinetics[14]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKM/PKM_activator /kinetics/chain/kinetics[14]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKM/PKM_synthesis /kinetics/chain/kinetics[14]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKM/PKM_activator /kinetics/chain/kinetics[14]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 /kinetics/chain/kinetics[14]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKM/Ca_detector /kinetics/chain/kinetics[14]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex /kinetics/chain/kinetics[14]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ca_diff /kinetics/chain/kinetics[14]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[14]/Ca /kinetics/chain/kinetics[14]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ca_input /kinetics/chain/kinetics[14]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[15]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[15]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[15]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[15]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[15]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca /kinetics/chain/kinetics[15]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca /kinetics/chain/kinetics[15]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ca /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca /kinetics/chain/kinetics[15]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[15]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[15]/DAG /kinetics/chain/kinetics[15]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca /kinetics/chain/kinetics[15]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[15]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[15]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[15]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/DAG /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG /kinetics/chain/kinetics[15]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[15]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[15]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG /kinetics/chain/kinetics[15]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG /kinetics/chain/kinetics[15]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[15]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[15]/PKM/PKM_degradation /kinetics/chain/kinetics[15]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[15]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[15]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKM-zeta /kinetics/chain/kinetics[15]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKM-zeta /kinetics/chain/kinetics[15]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[15]/DAG REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG /kinetics/chain/kinetics[15]/DAG REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[15]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[15]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[15]/PKC/PKM-zeta /kinetics/chain/kinetics[15]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[15]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[15]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[15]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[15]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[15]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[15]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[15]/PKC-active /kinetics/chain/kinetics[15]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1 /kinetics/chain/kinetics[15]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC-active /kinetics/chain/kinetics[15]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[15]/Ras/GAP /kinetics/chain/kinetics[15]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC-active /kinetics/chain/kinetics[15]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF /kinetics/chain/kinetics[15]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[15]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[15]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[15]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[14]/MAPK*/diff /kinetics/chain/kinetics[15]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[15]/MAPK*/diff /kinetics/chain/kinetics[15]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[15]/MAPK* /kinetics/chain/kinetics[15]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1* /kinetics/chain/kinetics[15]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK* /kinetics/chain/kinetics[15]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK* /kinetics/chain/kinetics[15]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[15]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[15]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[15]/Ras-act-unphosph-raf /kinetics/chain/kinetics[15]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1/diff /kinetics/chain/kinetics[15]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1/diff /kinetics/chain/kinetics[15]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1 /kinetics/chain/kinetics[15]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1 /kinetics/chain/kinetics[15]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[15]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[15]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[15]/Ras-act-craf /kinetics/chain/kinetics[15]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[15]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[15]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1*/diff /kinetics/chain/kinetics[15]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1*/diff /kinetics/chain/kinetics[15]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1* /kinetics/chain/kinetics[15]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1* /kinetics/chain/kinetics[15]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[15]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[15]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[15]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK/diff /kinetics/chain/kinetics[15]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK/diff /kinetics/chain/kinetics[15]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK /kinetics/chain/kinetics[15]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK /kinetics/chain/kinetics[15]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[15]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[15]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[15]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK/diff /kinetics/chain/kinetics[15]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK/diff /kinetics/chain/kinetics[15]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK /kinetics/chain/kinetics[15]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK /kinetics/chain/kinetics[15]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[15]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[15]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1**/diff /kinetics/chain/kinetics[15]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1**/diff /kinetics/chain/kinetics[15]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1** /kinetics/chain/kinetics[15]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1** /kinetics/chain/kinetics[15]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[15]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[15]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[15]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[15]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[15]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[15]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[15]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[15]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[15]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK* /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK* /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK* /kinetics/chain/kinetics[15]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK* /kinetics/chain/kinetics[15]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[15]/Ras-act-unphosph-raf /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[15]/Ras-act-craf /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[15]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[15]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[15]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[14]/MKP-1/diff /kinetics/chain/kinetics[15]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[15]/MKP-1/diff /kinetics/chain/kinetics[15]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr /kinetics/chain/kinetics[15]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MKP-1 /kinetics/chain/kinetics[15]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK* /kinetics/chain/kinetics[15]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MKP-1 /kinetics/chain/kinetics[15]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[15]/MKP-1 /kinetics/chain/kinetics[15]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MKP-1 /kinetics/chain/kinetics[15]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1* /kinetics/chain/kinetics[15]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[15]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ras/GTP-Ras /kinetics/chain/kinetics[15]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[15]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[15]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[15]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[15]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/diff /kinetics/chain/kinetics[15]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/diff /kinetics/chain/kinetics[15]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1* /kinetics/chain/kinetics[15]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A /kinetics/chain/kinetics[15]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK* /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1** /kinetics/chain/kinetics[15]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A /kinetics/chain/kinetics[15]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A /kinetics/chain/kinetics[15]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A /kinetics/chain/kinetics[15]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF /kinetics/chain/kinetics[15]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ras/GEF* /kinetics/chain/kinetics[15]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[15]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[15]/Ras/dephosph-GEF /kinetics/chain/kinetics[15]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[15]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[15]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[15]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF/diff /kinetics/chain/kinetics[15]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF/diff /kinetics/chain/kinetics[15]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF /kinetics/chain/kinetics[15]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[15]/Ras/GDP-Ras /kinetics/chain/kinetics[15]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF /kinetics/chain/kinetics[15]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF /kinetics/chain/kinetics[15]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[15]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[15]/Ras/dephosph-GEF /kinetics/chain/kinetics[15]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[15]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[14]/Ras/GEF*/diff /kinetics/chain/kinetics[15]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[15]/Ras/GEF*/diff /kinetics/chain/kinetics[15]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/GEF* /kinetics/chain/kinetics[15]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[15]/Ras/GDP-Ras /kinetics/chain/kinetics[15]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/GEF* /kinetics/chain/kinetics[15]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/GEF* /kinetics/chain/kinetics[15]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ras-act-craf /kinetics/chain/kinetics[15]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[15]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[15]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[15]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[15]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[15]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[15]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[15]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[15]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[15]/Ras-act-unphosph-raf /kinetics/chain/kinetics[15]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[15]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[15]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[15]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/GTP-Ras /kinetics/chain/kinetics[15]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/GTP-Ras /kinetics/chain/kinetics[15]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[15]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[15]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[15]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[15]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[15]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[15]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[15]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[15]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[15]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[14]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[15]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[15]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[15]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/GDP-Ras /kinetics/chain/kinetics[15]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/GDP-Ras /kinetics/chain/kinetics[15]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ras/GTP-Ras /kinetics/chain/kinetics[15]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/GDP-Ras /kinetics/chain/kinetics[15]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ras/GAP* /kinetics/chain/kinetics[15]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/GAP /kinetics/chain/kinetics[15]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[15]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[15]/Ras/dephosph-GAP /kinetics/chain/kinetics[15]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/GAP*/diff /kinetics/chain/kinetics[15]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[15]/Ras/GAP*/diff /kinetics/chain/kinetics[15]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/GAP* /kinetics/chain/kinetics[15]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/GAP* /kinetics/chain/kinetics[15]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[15]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[15]/Ras/dephosph-GAP /kinetics/chain/kinetics[15]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[15]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[15]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[14]/Ras/GAP/diff /kinetics/chain/kinetics[15]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[15]/Ras/GAP/diff /kinetics/chain/kinetics[15]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/GTP-Ras /kinetics/chain/kinetics[15]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/GAP /kinetics/chain/kinetics[15]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[15]/Ras/GAP /kinetics/chain/kinetics[15]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/GAP /kinetics/chain/kinetics[15]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF /kinetics/chain/kinetics[15]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/CaM-GEF /kinetics/chain/kinetics[15]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca4 /kinetics/chain/kinetics[15]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[15]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[15]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[15]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[14]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[15]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[15]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[15]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/GDP-Ras /kinetics/chain/kinetics[15]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/CaM-GEF /kinetics/chain/kinetics[15]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[15]/Ras/CaM-GEF /kinetics/chain/kinetics[15]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/CaM-GEF /kinetics/chain/kinetics[15]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[15]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM/diff /kinetics/chain/kinetics[15]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[15]/CaM/CaM/diff /kinetics/chain/kinetics[15]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM /kinetics/chain/kinetics[15]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM /kinetics/chain/kinetics[15]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca3 /kinetics/chain/kinetics[15]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca4 /kinetics/chain/kinetics[15]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[15]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[15]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca3 /kinetics/chain/kinetics[15]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca3 /kinetics/chain/kinetics[15]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[15]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[15]/PKM/trigger_PKM /kinetics/chain/kinetics[15]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[15]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[15]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca4 /kinetics/chain/kinetics[15]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca4 /kinetics/chain/kinetics[15]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/CaM/CaM /kinetics/chain/kinetics[15]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca /kinetics/chain/kinetics[15]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ca /kinetics/chain/kinetics[15]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[15]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[15]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca2 /kinetics/chain/kinetics[15]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca2 /kinetics/chain/kinetics[15]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca3 /kinetics/chain/kinetics[15]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca2 /kinetics/chain/kinetics[15]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca2 /kinetics/chain/kinetics[15]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[15]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[15]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[15]/Ca REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[15]/Ca REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[15]/Ca REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[15]/Ca REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[15]/Ca REAC A B addmsg /kinetics/chain/kinetics[15]/Ca_diff /kinetics/chain/kinetics[15]/Ca REAC B A addmsg /kinetics/chain/kinetics[14]/Ca/diff /kinetics/chain/kinetics[15]/Ca REAC B A addmsg /kinetics/chain/kinetics[15]/Ca/diff /kinetics/chain/kinetics[15]/Ca REAC A B addmsg /kinetics/chain/kinetics[15]/Ca /kinetics/chain/kinetics[15]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ca /kinetics/chain/kinetics[15]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1 /kinetics/chain/kinetics[15]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[15]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ras/GTP-Ras /kinetics/chain/kinetics[15]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKM/trigger_PKM /kinetics/chain/kinetics[15]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[14]/PKM/Ca_detector/diff /kinetics/chain/kinetics[15]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[15]/PKM/Ca_detector/diff /kinetics/chain/kinetics[15]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[15]/PKM/Ca_detector /kinetics/chain/kinetics[15]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKM/Ca_detector /kinetics/chain/kinetics[15]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[15]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[15]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[15]/PKM/turn_off_activator /kinetics/chain/kinetics[15]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[14]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[15]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[15]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[15]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[15]/PKM/PKM_synthesis /kinetics/chain/kinetics[15]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[15]/PKM/AA_pool /kinetics/chain/kinetics[15]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKM/PKM_synthesis /kinetics/chain/kinetics[15]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKM/PKM_synthesis /kinetics/chain/kinetics[15]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[15]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[15]/PKC/PKM-zeta /kinetics/chain/kinetics[15]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKM/degraded_PKM /kinetics/chain/kinetics[15]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKM/PKM_degradation /kinetics/chain/kinetics[15]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[15]/PKM/trigger_PKM /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[14]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[15]/PKM/PKM_activator /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[15]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[15]/PKM/turn_off_activator /kinetics/chain/kinetics[15]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[14]/PKM/PKM_activator/diff /kinetics/chain/kinetics[15]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[15]/PKM/PKM_activator/diff /kinetics/chain/kinetics[15]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[15]/PKM/PKM_activator /kinetics/chain/kinetics[15]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKM/PKM_activator /kinetics/chain/kinetics[15]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKM/PKM_synthesis /kinetics/chain/kinetics[15]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKM/PKM_activator /kinetics/chain/kinetics[15]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca4 /kinetics/chain/kinetics[15]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKM/Ca_detector /kinetics/chain/kinetics[15]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex /kinetics/chain/kinetics[15]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ca_diff /kinetics/chain/kinetics[15]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[15]/Ca /kinetics/chain/kinetics[15]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ca_input /kinetics/chain/kinetics[15]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[16]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[16]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[16]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[16]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[16]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca /kinetics/chain/kinetics[16]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca /kinetics/chain/kinetics[16]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ca /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca /kinetics/chain/kinetics[16]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[16]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[16]/DAG /kinetics/chain/kinetics[16]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca /kinetics/chain/kinetics[16]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[16]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[16]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[16]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/DAG /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG /kinetics/chain/kinetics[16]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[16]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[16]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG /kinetics/chain/kinetics[16]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG /kinetics/chain/kinetics[16]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[16]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[16]/PKM/PKM_degradation /kinetics/chain/kinetics[16]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[16]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[16]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKM-zeta /kinetics/chain/kinetics[16]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKM-zeta /kinetics/chain/kinetics[16]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[16]/DAG REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG /kinetics/chain/kinetics[16]/DAG REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[16]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[16]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[16]/PKC/PKM-zeta /kinetics/chain/kinetics[16]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[16]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[16]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[16]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[16]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[16]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[16]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[16]/PKC-active /kinetics/chain/kinetics[16]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1 /kinetics/chain/kinetics[16]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC-active /kinetics/chain/kinetics[16]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[16]/Ras/GAP /kinetics/chain/kinetics[16]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC-active /kinetics/chain/kinetics[16]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF /kinetics/chain/kinetics[16]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[16]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[16]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[16]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[15]/MAPK*/diff /kinetics/chain/kinetics[16]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[16]/MAPK*/diff /kinetics/chain/kinetics[16]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[16]/MAPK* /kinetics/chain/kinetics[16]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1* /kinetics/chain/kinetics[16]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK* /kinetics/chain/kinetics[16]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK* /kinetics/chain/kinetics[16]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[16]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[16]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[16]/Ras-act-unphosph-raf /kinetics/chain/kinetics[16]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1/diff /kinetics/chain/kinetics[16]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1/diff /kinetics/chain/kinetics[16]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1 /kinetics/chain/kinetics[16]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1 /kinetics/chain/kinetics[16]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[16]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[16]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[16]/Ras-act-craf /kinetics/chain/kinetics[16]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[16]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[16]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1*/diff /kinetics/chain/kinetics[16]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1*/diff /kinetics/chain/kinetics[16]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1* /kinetics/chain/kinetics[16]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1* /kinetics/chain/kinetics[16]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[16]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[16]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[16]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK/diff /kinetics/chain/kinetics[16]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK/diff /kinetics/chain/kinetics[16]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK /kinetics/chain/kinetics[16]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK /kinetics/chain/kinetics[16]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[16]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[16]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[16]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK/diff /kinetics/chain/kinetics[16]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK/diff /kinetics/chain/kinetics[16]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK /kinetics/chain/kinetics[16]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK /kinetics/chain/kinetics[16]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[16]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[16]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1**/diff /kinetics/chain/kinetics[16]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1**/diff /kinetics/chain/kinetics[16]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1** /kinetics/chain/kinetics[16]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1** /kinetics/chain/kinetics[16]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[16]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[16]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[16]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[16]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[16]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[16]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[16]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[16]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[16]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK* /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK* /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK* /kinetics/chain/kinetics[16]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK* /kinetics/chain/kinetics[16]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[16]/Ras-act-unphosph-raf /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[16]/Ras-act-craf /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[16]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[16]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[16]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[15]/MKP-1/diff /kinetics/chain/kinetics[16]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[16]/MKP-1/diff /kinetics/chain/kinetics[16]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr /kinetics/chain/kinetics[16]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MKP-1 /kinetics/chain/kinetics[16]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK* /kinetics/chain/kinetics[16]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MKP-1 /kinetics/chain/kinetics[16]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[16]/MKP-1 /kinetics/chain/kinetics[16]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MKP-1 /kinetics/chain/kinetics[16]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1* /kinetics/chain/kinetics[16]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[16]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ras/GTP-Ras /kinetics/chain/kinetics[16]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[16]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[16]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[16]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[16]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/diff /kinetics/chain/kinetics[16]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/diff /kinetics/chain/kinetics[16]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1* /kinetics/chain/kinetics[16]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A /kinetics/chain/kinetics[16]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK* /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1** /kinetics/chain/kinetics[16]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A /kinetics/chain/kinetics[16]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A /kinetics/chain/kinetics[16]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A /kinetics/chain/kinetics[16]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF /kinetics/chain/kinetics[16]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ras/GEF* /kinetics/chain/kinetics[16]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[16]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[16]/Ras/dephosph-GEF /kinetics/chain/kinetics[16]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[16]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[16]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[16]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF/diff /kinetics/chain/kinetics[16]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF/diff /kinetics/chain/kinetics[16]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF /kinetics/chain/kinetics[16]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[16]/Ras/GDP-Ras /kinetics/chain/kinetics[16]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF /kinetics/chain/kinetics[16]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF /kinetics/chain/kinetics[16]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[16]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[16]/Ras/dephosph-GEF /kinetics/chain/kinetics[16]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[16]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[15]/Ras/GEF*/diff /kinetics/chain/kinetics[16]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[16]/Ras/GEF*/diff /kinetics/chain/kinetics[16]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/GEF* /kinetics/chain/kinetics[16]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[16]/Ras/GDP-Ras /kinetics/chain/kinetics[16]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/GEF* /kinetics/chain/kinetics[16]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/GEF* /kinetics/chain/kinetics[16]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ras-act-craf /kinetics/chain/kinetics[16]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[16]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[16]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[16]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[16]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[16]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[16]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[16]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[16]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[16]/Ras-act-unphosph-raf /kinetics/chain/kinetics[16]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[16]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[16]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[16]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/GTP-Ras /kinetics/chain/kinetics[16]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/GTP-Ras /kinetics/chain/kinetics[16]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[16]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[16]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[16]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[16]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[16]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[16]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[16]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[16]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[16]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[15]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[16]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[16]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[16]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/GDP-Ras /kinetics/chain/kinetics[16]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/GDP-Ras /kinetics/chain/kinetics[16]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ras/GTP-Ras /kinetics/chain/kinetics[16]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/GDP-Ras /kinetics/chain/kinetics[16]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ras/GAP* /kinetics/chain/kinetics[16]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/GAP /kinetics/chain/kinetics[16]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[16]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[16]/Ras/dephosph-GAP /kinetics/chain/kinetics[16]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/GAP*/diff /kinetics/chain/kinetics[16]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[16]/Ras/GAP*/diff /kinetics/chain/kinetics[16]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/GAP* /kinetics/chain/kinetics[16]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/GAP* /kinetics/chain/kinetics[16]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[16]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[16]/Ras/dephosph-GAP /kinetics/chain/kinetics[16]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[16]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[16]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[15]/Ras/GAP/diff /kinetics/chain/kinetics[16]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[16]/Ras/GAP/diff /kinetics/chain/kinetics[16]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/GTP-Ras /kinetics/chain/kinetics[16]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/GAP /kinetics/chain/kinetics[16]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[16]/Ras/GAP /kinetics/chain/kinetics[16]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/GAP /kinetics/chain/kinetics[16]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF /kinetics/chain/kinetics[16]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/CaM-GEF /kinetics/chain/kinetics[16]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca4 /kinetics/chain/kinetics[16]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[16]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[16]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[16]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[15]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[16]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[16]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[16]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/GDP-Ras /kinetics/chain/kinetics[16]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/CaM-GEF /kinetics/chain/kinetics[16]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[16]/Ras/CaM-GEF /kinetics/chain/kinetics[16]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/CaM-GEF /kinetics/chain/kinetics[16]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[16]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM/diff /kinetics/chain/kinetics[16]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[16]/CaM/CaM/diff /kinetics/chain/kinetics[16]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM /kinetics/chain/kinetics[16]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM /kinetics/chain/kinetics[16]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca3 /kinetics/chain/kinetics[16]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca4 /kinetics/chain/kinetics[16]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[16]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[16]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca3 /kinetics/chain/kinetics[16]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca3 /kinetics/chain/kinetics[16]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[16]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[16]/PKM/trigger_PKM /kinetics/chain/kinetics[16]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[16]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[16]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca4 /kinetics/chain/kinetics[16]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 /kinetics/chain/kinetics[16]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/CaM/CaM /kinetics/chain/kinetics[16]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca /kinetics/chain/kinetics[16]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ca /kinetics/chain/kinetics[16]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[16]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[16]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca2 /kinetics/chain/kinetics[16]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca2 /kinetics/chain/kinetics[16]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca3 /kinetics/chain/kinetics[16]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca2 /kinetics/chain/kinetics[16]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca2 /kinetics/chain/kinetics[16]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[16]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[16]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[16]/Ca REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[16]/Ca REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[16]/Ca REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[16]/Ca REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[16]/Ca REAC A B addmsg /kinetics/chain/kinetics[16]/Ca_diff /kinetics/chain/kinetics[16]/Ca REAC B A addmsg /kinetics/chain/kinetics[15]/Ca/diff /kinetics/chain/kinetics[16]/Ca REAC B A addmsg /kinetics/chain/kinetics[16]/Ca/diff /kinetics/chain/kinetics[16]/Ca REAC A B addmsg /kinetics/chain/kinetics[16]/Ca /kinetics/chain/kinetics[16]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ca /kinetics/chain/kinetics[16]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1 /kinetics/chain/kinetics[16]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[16]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ras/GTP-Ras /kinetics/chain/kinetics[16]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKM/trigger_PKM /kinetics/chain/kinetics[16]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[15]/PKM/Ca_detector/diff /kinetics/chain/kinetics[16]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[16]/PKM/Ca_detector/diff /kinetics/chain/kinetics[16]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[16]/PKM/Ca_detector /kinetics/chain/kinetics[16]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKM/Ca_detector /kinetics/chain/kinetics[16]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[16]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[16]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[16]/PKM/turn_off_activator /kinetics/chain/kinetics[16]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[15]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[16]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[16]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[16]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[16]/PKM/PKM_synthesis /kinetics/chain/kinetics[16]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[16]/PKM/AA_pool /kinetics/chain/kinetics[16]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKM/PKM_synthesis /kinetics/chain/kinetics[16]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKM/PKM_synthesis /kinetics/chain/kinetics[16]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[16]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[16]/PKC/PKM-zeta /kinetics/chain/kinetics[16]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKM/degraded_PKM /kinetics/chain/kinetics[16]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKM/PKM_degradation /kinetics/chain/kinetics[16]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[16]/PKM/trigger_PKM /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[15]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[16]/PKM/PKM_activator /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[16]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[16]/PKM/turn_off_activator /kinetics/chain/kinetics[16]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[15]/PKM/PKM_activator/diff /kinetics/chain/kinetics[16]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[16]/PKM/PKM_activator/diff /kinetics/chain/kinetics[16]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[16]/PKM/PKM_activator /kinetics/chain/kinetics[16]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKM/PKM_activator /kinetics/chain/kinetics[16]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKM/PKM_synthesis /kinetics/chain/kinetics[16]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKM/PKM_activator /kinetics/chain/kinetics[16]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca4 /kinetics/chain/kinetics[16]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKM/Ca_detector /kinetics/chain/kinetics[16]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex /kinetics/chain/kinetics[16]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ca_diff /kinetics/chain/kinetics[16]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[16]/Ca /kinetics/chain/kinetics[16]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ca_input /kinetics/chain/kinetics[16]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[17]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[17]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[17]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[17]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[17]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca /kinetics/chain/kinetics[17]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca /kinetics/chain/kinetics[17]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ca /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca /kinetics/chain/kinetics[17]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[17]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[17]/DAG /kinetics/chain/kinetics[17]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca /kinetics/chain/kinetics[17]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[17]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[17]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[17]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/DAG /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG /kinetics/chain/kinetics[17]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[17]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[17]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG /kinetics/chain/kinetics[17]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG /kinetics/chain/kinetics[17]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[17]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[17]/PKM/PKM_degradation /kinetics/chain/kinetics[17]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[17]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[17]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKM-zeta /kinetics/chain/kinetics[17]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKM-zeta /kinetics/chain/kinetics[17]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[17]/DAG REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG /kinetics/chain/kinetics[17]/DAG REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[17]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[17]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[17]/PKC/PKM-zeta /kinetics/chain/kinetics[17]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[17]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[17]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[17]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[17]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[17]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[17]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[17]/PKC-active /kinetics/chain/kinetics[17]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1 /kinetics/chain/kinetics[17]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC-active /kinetics/chain/kinetics[17]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[17]/Ras/GAP /kinetics/chain/kinetics[17]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC-active /kinetics/chain/kinetics[17]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF /kinetics/chain/kinetics[17]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[17]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[17]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[17]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[16]/MAPK*/diff /kinetics/chain/kinetics[17]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[17]/MAPK*/diff /kinetics/chain/kinetics[17]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[17]/MAPK* /kinetics/chain/kinetics[17]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1* /kinetics/chain/kinetics[17]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK* /kinetics/chain/kinetics[17]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK* /kinetics/chain/kinetics[17]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[17]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[17]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[17]/Ras-act-unphosph-raf /kinetics/chain/kinetics[17]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1/diff /kinetics/chain/kinetics[17]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1/diff /kinetics/chain/kinetics[17]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1 /kinetics/chain/kinetics[17]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1 /kinetics/chain/kinetics[17]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[17]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[17]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[17]/Ras-act-craf /kinetics/chain/kinetics[17]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[17]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[17]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1*/diff /kinetics/chain/kinetics[17]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1*/diff /kinetics/chain/kinetics[17]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1* /kinetics/chain/kinetics[17]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1* /kinetics/chain/kinetics[17]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[17]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[17]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[17]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK/diff /kinetics/chain/kinetics[17]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK/diff /kinetics/chain/kinetics[17]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK /kinetics/chain/kinetics[17]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK /kinetics/chain/kinetics[17]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[17]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[17]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[17]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK/diff /kinetics/chain/kinetics[17]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK/diff /kinetics/chain/kinetics[17]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK /kinetics/chain/kinetics[17]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK /kinetics/chain/kinetics[17]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[17]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[17]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1**/diff /kinetics/chain/kinetics[17]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1**/diff /kinetics/chain/kinetics[17]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1** /kinetics/chain/kinetics[17]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1** /kinetics/chain/kinetics[17]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[17]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[17]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[17]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[17]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[17]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[17]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[17]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[17]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[17]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK* /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK* /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK* /kinetics/chain/kinetics[17]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK* /kinetics/chain/kinetics[17]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[17]/Ras-act-unphosph-raf /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[17]/Ras-act-craf /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[17]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[17]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[17]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[16]/MKP-1/diff /kinetics/chain/kinetics[17]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[17]/MKP-1/diff /kinetics/chain/kinetics[17]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr /kinetics/chain/kinetics[17]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MKP-1 /kinetics/chain/kinetics[17]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK* /kinetics/chain/kinetics[17]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MKP-1 /kinetics/chain/kinetics[17]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[17]/MKP-1 /kinetics/chain/kinetics[17]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MKP-1 /kinetics/chain/kinetics[17]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1* /kinetics/chain/kinetics[17]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[17]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ras/GTP-Ras /kinetics/chain/kinetics[17]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[17]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[17]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[17]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[17]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/diff /kinetics/chain/kinetics[17]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/diff /kinetics/chain/kinetics[17]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1* /kinetics/chain/kinetics[17]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A /kinetics/chain/kinetics[17]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK* /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1** /kinetics/chain/kinetics[17]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A /kinetics/chain/kinetics[17]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A /kinetics/chain/kinetics[17]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A /kinetics/chain/kinetics[17]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF /kinetics/chain/kinetics[17]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ras/GEF* /kinetics/chain/kinetics[17]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[17]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[17]/Ras/dephosph-GEF /kinetics/chain/kinetics[17]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[17]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[17]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[17]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF/diff /kinetics/chain/kinetics[17]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF/diff /kinetics/chain/kinetics[17]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF /kinetics/chain/kinetics[17]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[17]/Ras/GDP-Ras /kinetics/chain/kinetics[17]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF /kinetics/chain/kinetics[17]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF /kinetics/chain/kinetics[17]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[17]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[17]/Ras/dephosph-GEF /kinetics/chain/kinetics[17]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[17]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[16]/Ras/GEF*/diff /kinetics/chain/kinetics[17]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[17]/Ras/GEF*/diff /kinetics/chain/kinetics[17]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/GEF* /kinetics/chain/kinetics[17]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[17]/Ras/GDP-Ras /kinetics/chain/kinetics[17]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/GEF* /kinetics/chain/kinetics[17]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/GEF* /kinetics/chain/kinetics[17]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ras-act-craf /kinetics/chain/kinetics[17]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[17]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[17]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[17]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[17]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[17]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[17]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[17]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[17]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[17]/Ras-act-unphosph-raf /kinetics/chain/kinetics[17]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[17]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[17]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[17]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/GTP-Ras /kinetics/chain/kinetics[17]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/GTP-Ras /kinetics/chain/kinetics[17]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[17]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[17]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[17]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[17]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[17]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[17]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[17]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[17]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[17]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[16]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[17]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[17]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[17]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/GDP-Ras /kinetics/chain/kinetics[17]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/GDP-Ras /kinetics/chain/kinetics[17]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ras/GTP-Ras /kinetics/chain/kinetics[17]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/GDP-Ras /kinetics/chain/kinetics[17]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ras/GAP* /kinetics/chain/kinetics[17]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/GAP /kinetics/chain/kinetics[17]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[17]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[17]/Ras/dephosph-GAP /kinetics/chain/kinetics[17]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/GAP*/diff /kinetics/chain/kinetics[17]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[17]/Ras/GAP*/diff /kinetics/chain/kinetics[17]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/GAP* /kinetics/chain/kinetics[17]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/GAP* /kinetics/chain/kinetics[17]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[17]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[17]/Ras/dephosph-GAP /kinetics/chain/kinetics[17]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[17]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[17]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[16]/Ras/GAP/diff /kinetics/chain/kinetics[17]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[17]/Ras/GAP/diff /kinetics/chain/kinetics[17]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/GTP-Ras /kinetics/chain/kinetics[17]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/GAP /kinetics/chain/kinetics[17]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[17]/Ras/GAP /kinetics/chain/kinetics[17]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/GAP /kinetics/chain/kinetics[17]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF /kinetics/chain/kinetics[17]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/CaM-GEF /kinetics/chain/kinetics[17]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 /kinetics/chain/kinetics[17]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[17]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[17]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[17]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[16]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[17]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[17]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[17]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/GDP-Ras /kinetics/chain/kinetics[17]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/CaM-GEF /kinetics/chain/kinetics[17]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[17]/Ras/CaM-GEF /kinetics/chain/kinetics[17]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/CaM-GEF /kinetics/chain/kinetics[17]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[17]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM/diff /kinetics/chain/kinetics[17]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[17]/CaM/CaM/diff /kinetics/chain/kinetics[17]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM /kinetics/chain/kinetics[17]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM /kinetics/chain/kinetics[17]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca3 /kinetics/chain/kinetics[17]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 /kinetics/chain/kinetics[17]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[17]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[17]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca3 /kinetics/chain/kinetics[17]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca3 /kinetics/chain/kinetics[17]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[17]/PKM/trigger_PKM /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 /kinetics/chain/kinetics[17]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca4 /kinetics/chain/kinetics[17]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/CaM/CaM /kinetics/chain/kinetics[17]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca /kinetics/chain/kinetics[17]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ca /kinetics/chain/kinetics[17]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[17]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[17]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca2 /kinetics/chain/kinetics[17]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca2 /kinetics/chain/kinetics[17]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca3 /kinetics/chain/kinetics[17]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca2 /kinetics/chain/kinetics[17]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca2 /kinetics/chain/kinetics[17]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[17]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[17]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[17]/Ca REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[17]/Ca REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[17]/Ca REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[17]/Ca REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[17]/Ca REAC A B addmsg /kinetics/chain/kinetics[17]/Ca_diff /kinetics/chain/kinetics[17]/Ca REAC B A addmsg /kinetics/chain/kinetics[16]/Ca/diff /kinetics/chain/kinetics[17]/Ca REAC B A addmsg /kinetics/chain/kinetics[17]/Ca/diff /kinetics/chain/kinetics[17]/Ca REAC A B addmsg /kinetics/chain/kinetics[17]/Ca /kinetics/chain/kinetics[17]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ca /kinetics/chain/kinetics[17]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1 /kinetics/chain/kinetics[17]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[17]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ras/GTP-Ras /kinetics/chain/kinetics[17]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKM/trigger_PKM /kinetics/chain/kinetics[17]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[16]/PKM/Ca_detector/diff /kinetics/chain/kinetics[17]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[17]/PKM/Ca_detector/diff /kinetics/chain/kinetics[17]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[17]/PKM/Ca_detector /kinetics/chain/kinetics[17]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKM/Ca_detector /kinetics/chain/kinetics[17]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[17]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[17]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[17]/PKM/turn_off_activator /kinetics/chain/kinetics[17]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[16]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[17]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[17]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[17]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[17]/PKM/PKM_synthesis /kinetics/chain/kinetics[17]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[17]/PKM/AA_pool /kinetics/chain/kinetics[17]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKM/PKM_synthesis /kinetics/chain/kinetics[17]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKM/PKM_synthesis /kinetics/chain/kinetics[17]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[17]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[17]/PKC/PKM-zeta /kinetics/chain/kinetics[17]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKM/degraded_PKM /kinetics/chain/kinetics[17]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKM/PKM_degradation /kinetics/chain/kinetics[17]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[17]/PKM/trigger_PKM /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[16]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[17]/PKM/PKM_activator /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[17]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[17]/PKM/turn_off_activator /kinetics/chain/kinetics[17]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[16]/PKM/PKM_activator/diff /kinetics/chain/kinetics[17]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[17]/PKM/PKM_activator/diff /kinetics/chain/kinetics[17]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[17]/PKM/PKM_activator /kinetics/chain/kinetics[17]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKM/PKM_activator /kinetics/chain/kinetics[17]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKM/PKM_synthesis /kinetics/chain/kinetics[17]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKM/PKM_activator /kinetics/chain/kinetics[17]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 /kinetics/chain/kinetics[17]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKM/Ca_detector /kinetics/chain/kinetics[17]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex /kinetics/chain/kinetics[17]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ca_diff /kinetics/chain/kinetics[17]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[17]/Ca /kinetics/chain/kinetics[17]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ca_input /kinetics/chain/kinetics[17]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[18]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[18]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[18]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[18]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[18]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca /kinetics/chain/kinetics[18]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca /kinetics/chain/kinetics[18]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ca /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca /kinetics/chain/kinetics[18]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[18]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[18]/DAG /kinetics/chain/kinetics[18]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca /kinetics/chain/kinetics[18]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[18]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[18]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[18]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/DAG /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG /kinetics/chain/kinetics[18]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[18]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[18]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG /kinetics/chain/kinetics[18]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG /kinetics/chain/kinetics[18]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[18]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[18]/PKM/PKM_degradation /kinetics/chain/kinetics[18]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[18]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[18]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKM-zeta /kinetics/chain/kinetics[18]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKM-zeta /kinetics/chain/kinetics[18]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[18]/DAG REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG /kinetics/chain/kinetics[18]/DAG REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[18]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[18]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[18]/PKC/PKM-zeta /kinetics/chain/kinetics[18]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[18]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[18]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[18]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[18]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[18]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[18]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[18]/PKC-active /kinetics/chain/kinetics[18]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1 /kinetics/chain/kinetics[18]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC-active /kinetics/chain/kinetics[18]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[18]/Ras/GAP /kinetics/chain/kinetics[18]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC-active /kinetics/chain/kinetics[18]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF /kinetics/chain/kinetics[18]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[18]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[18]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[18]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[17]/MAPK*/diff /kinetics/chain/kinetics[18]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[18]/MAPK*/diff /kinetics/chain/kinetics[18]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[18]/MAPK* /kinetics/chain/kinetics[18]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1* /kinetics/chain/kinetics[18]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK* /kinetics/chain/kinetics[18]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK* /kinetics/chain/kinetics[18]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[18]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[18]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[18]/Ras-act-unphosph-raf /kinetics/chain/kinetics[18]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1/diff /kinetics/chain/kinetics[18]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1/diff /kinetics/chain/kinetics[18]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1 /kinetics/chain/kinetics[18]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1 /kinetics/chain/kinetics[18]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[18]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[18]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[18]/Ras-act-craf /kinetics/chain/kinetics[18]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[18]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[18]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1*/diff /kinetics/chain/kinetics[18]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1*/diff /kinetics/chain/kinetics[18]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1* /kinetics/chain/kinetics[18]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1* /kinetics/chain/kinetics[18]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[18]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[18]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[18]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK/diff /kinetics/chain/kinetics[18]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK/diff /kinetics/chain/kinetics[18]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK /kinetics/chain/kinetics[18]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK /kinetics/chain/kinetics[18]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[18]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[18]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[18]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK/diff /kinetics/chain/kinetics[18]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK/diff /kinetics/chain/kinetics[18]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK /kinetics/chain/kinetics[18]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK /kinetics/chain/kinetics[18]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[18]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[18]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1**/diff /kinetics/chain/kinetics[18]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1**/diff /kinetics/chain/kinetics[18]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1** /kinetics/chain/kinetics[18]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1** /kinetics/chain/kinetics[18]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[18]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[18]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[18]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[18]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[18]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[18]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[18]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[18]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[18]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK* /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK* /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK* /kinetics/chain/kinetics[18]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK* /kinetics/chain/kinetics[18]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[18]/Ras-act-unphosph-raf /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[18]/Ras-act-craf /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[18]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[18]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[18]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[17]/MKP-1/diff /kinetics/chain/kinetics[18]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[18]/MKP-1/diff /kinetics/chain/kinetics[18]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr /kinetics/chain/kinetics[18]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MKP-1 /kinetics/chain/kinetics[18]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK* /kinetics/chain/kinetics[18]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MKP-1 /kinetics/chain/kinetics[18]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[18]/MKP-1 /kinetics/chain/kinetics[18]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MKP-1 /kinetics/chain/kinetics[18]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1* /kinetics/chain/kinetics[18]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[18]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ras/GTP-Ras /kinetics/chain/kinetics[18]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[18]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[18]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[18]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[18]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/diff /kinetics/chain/kinetics[18]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/diff /kinetics/chain/kinetics[18]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1* /kinetics/chain/kinetics[18]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A /kinetics/chain/kinetics[18]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK* /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1** /kinetics/chain/kinetics[18]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A /kinetics/chain/kinetics[18]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A /kinetics/chain/kinetics[18]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A /kinetics/chain/kinetics[18]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF /kinetics/chain/kinetics[18]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ras/GEF* /kinetics/chain/kinetics[18]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[18]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[18]/Ras/dephosph-GEF /kinetics/chain/kinetics[18]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[18]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[18]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[18]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF/diff /kinetics/chain/kinetics[18]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF/diff /kinetics/chain/kinetics[18]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF /kinetics/chain/kinetics[18]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[18]/Ras/GDP-Ras /kinetics/chain/kinetics[18]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF /kinetics/chain/kinetics[18]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF /kinetics/chain/kinetics[18]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[18]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[18]/Ras/dephosph-GEF /kinetics/chain/kinetics[18]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[18]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[17]/Ras/GEF*/diff /kinetics/chain/kinetics[18]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[18]/Ras/GEF*/diff /kinetics/chain/kinetics[18]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/GEF* /kinetics/chain/kinetics[18]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[18]/Ras/GDP-Ras /kinetics/chain/kinetics[18]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/GEF* /kinetics/chain/kinetics[18]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/GEF* /kinetics/chain/kinetics[18]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ras-act-craf /kinetics/chain/kinetics[18]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[18]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[18]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[18]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[18]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[18]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[18]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[18]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[18]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[18]/Ras-act-unphosph-raf /kinetics/chain/kinetics[18]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[18]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[18]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[18]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/GTP-Ras /kinetics/chain/kinetics[18]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/GTP-Ras /kinetics/chain/kinetics[18]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[18]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[18]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[18]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[18]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[18]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[18]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[18]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[18]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[18]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[17]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[18]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[18]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[18]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/GDP-Ras /kinetics/chain/kinetics[18]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/GDP-Ras /kinetics/chain/kinetics[18]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ras/GTP-Ras /kinetics/chain/kinetics[18]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/GDP-Ras /kinetics/chain/kinetics[18]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ras/GAP* /kinetics/chain/kinetics[18]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/GAP /kinetics/chain/kinetics[18]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[18]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[18]/Ras/dephosph-GAP /kinetics/chain/kinetics[18]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/GAP*/diff /kinetics/chain/kinetics[18]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[18]/Ras/GAP*/diff /kinetics/chain/kinetics[18]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/GAP* /kinetics/chain/kinetics[18]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/GAP* /kinetics/chain/kinetics[18]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[18]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[18]/Ras/dephosph-GAP /kinetics/chain/kinetics[18]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[18]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[18]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[17]/Ras/GAP/diff /kinetics/chain/kinetics[18]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[18]/Ras/GAP/diff /kinetics/chain/kinetics[18]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/GTP-Ras /kinetics/chain/kinetics[18]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/GAP /kinetics/chain/kinetics[18]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[18]/Ras/GAP /kinetics/chain/kinetics[18]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/GAP /kinetics/chain/kinetics[18]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF /kinetics/chain/kinetics[18]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/CaM-GEF /kinetics/chain/kinetics[18]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca4 /kinetics/chain/kinetics[18]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[18]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[18]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[18]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[17]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[18]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[18]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[18]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/GDP-Ras /kinetics/chain/kinetics[18]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/CaM-GEF /kinetics/chain/kinetics[18]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[18]/Ras/CaM-GEF /kinetics/chain/kinetics[18]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/CaM-GEF /kinetics/chain/kinetics[18]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[18]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM/diff /kinetics/chain/kinetics[18]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[18]/CaM/CaM/diff /kinetics/chain/kinetics[18]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM /kinetics/chain/kinetics[18]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM /kinetics/chain/kinetics[18]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca3 /kinetics/chain/kinetics[18]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca4 /kinetics/chain/kinetics[18]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[18]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[18]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca3 /kinetics/chain/kinetics[18]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca3 /kinetics/chain/kinetics[18]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[18]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[18]/PKM/trigger_PKM /kinetics/chain/kinetics[18]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[18]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[18]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca4 /kinetics/chain/kinetics[18]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 /kinetics/chain/kinetics[18]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/CaM/CaM /kinetics/chain/kinetics[18]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca /kinetics/chain/kinetics[18]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ca /kinetics/chain/kinetics[18]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[18]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[18]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca2 /kinetics/chain/kinetics[18]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca2 /kinetics/chain/kinetics[18]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca3 /kinetics/chain/kinetics[18]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca2 /kinetics/chain/kinetics[18]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca2 /kinetics/chain/kinetics[18]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[18]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[18]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[18]/Ca REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[18]/Ca REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[18]/Ca REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[18]/Ca REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[18]/Ca REAC A B addmsg /kinetics/chain/kinetics[18]/Ca_diff /kinetics/chain/kinetics[18]/Ca REAC B A addmsg /kinetics/chain/kinetics[17]/Ca/diff /kinetics/chain/kinetics[18]/Ca REAC B A addmsg /kinetics/chain/kinetics[18]/Ca/diff /kinetics/chain/kinetics[18]/Ca REAC A B addmsg /kinetics/chain/kinetics[18]/Ca /kinetics/chain/kinetics[18]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ca /kinetics/chain/kinetics[18]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1 /kinetics/chain/kinetics[18]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[18]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ras/GTP-Ras /kinetics/chain/kinetics[18]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKM/trigger_PKM /kinetics/chain/kinetics[18]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[17]/PKM/Ca_detector/diff /kinetics/chain/kinetics[18]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[18]/PKM/Ca_detector/diff /kinetics/chain/kinetics[18]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[18]/PKM/Ca_detector /kinetics/chain/kinetics[18]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKM/Ca_detector /kinetics/chain/kinetics[18]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[18]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[18]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[18]/PKM/turn_off_activator /kinetics/chain/kinetics[18]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[17]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[18]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[18]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[18]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[18]/PKM/PKM_synthesis /kinetics/chain/kinetics[18]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[18]/PKM/AA_pool /kinetics/chain/kinetics[18]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKM/PKM_synthesis /kinetics/chain/kinetics[18]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKM/PKM_synthesis /kinetics/chain/kinetics[18]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[18]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[18]/PKC/PKM-zeta /kinetics/chain/kinetics[18]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKM/degraded_PKM /kinetics/chain/kinetics[18]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKM/PKM_degradation /kinetics/chain/kinetics[18]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[18]/PKM/trigger_PKM /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[17]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[18]/PKM/PKM_activator /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[18]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[18]/PKM/turn_off_activator /kinetics/chain/kinetics[18]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[17]/PKM/PKM_activator/diff /kinetics/chain/kinetics[18]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[18]/PKM/PKM_activator/diff /kinetics/chain/kinetics[18]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[18]/PKM/PKM_activator /kinetics/chain/kinetics[18]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKM/PKM_activator /kinetics/chain/kinetics[18]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKM/PKM_synthesis /kinetics/chain/kinetics[18]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKM/PKM_activator /kinetics/chain/kinetics[18]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca4 /kinetics/chain/kinetics[18]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKM/Ca_detector /kinetics/chain/kinetics[18]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex /kinetics/chain/kinetics[18]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ca_diff /kinetics/chain/kinetics[18]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[18]/Ca /kinetics/chain/kinetics[18]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ca_input /kinetics/chain/kinetics[18]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[19]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[19]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[19]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[19]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[19]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca /kinetics/chain/kinetics[19]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca /kinetics/chain/kinetics[19]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ca /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca /kinetics/chain/kinetics[19]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[19]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[19]/DAG /kinetics/chain/kinetics[19]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca /kinetics/chain/kinetics[19]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[19]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[19]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[19]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/DAG /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG /kinetics/chain/kinetics[19]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[19]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[19]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG /kinetics/chain/kinetics[19]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG /kinetics/chain/kinetics[19]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[19]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[19]/PKM/PKM_degradation /kinetics/chain/kinetics[19]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[19]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[19]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKM-zeta /kinetics/chain/kinetics[19]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKM-zeta /kinetics/chain/kinetics[19]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[19]/DAG REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG /kinetics/chain/kinetics[19]/DAG REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[19]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[19]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[19]/PKC/PKM-zeta /kinetics/chain/kinetics[19]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[19]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[19]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[19]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[19]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[19]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[19]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[19]/PKC-active /kinetics/chain/kinetics[19]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1 /kinetics/chain/kinetics[19]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC-active /kinetics/chain/kinetics[19]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[19]/Ras/GAP /kinetics/chain/kinetics[19]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC-active /kinetics/chain/kinetics[19]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF /kinetics/chain/kinetics[19]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[19]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[19]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[19]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[18]/MAPK*/diff /kinetics/chain/kinetics[19]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[19]/MAPK*/diff /kinetics/chain/kinetics[19]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[19]/MAPK* /kinetics/chain/kinetics[19]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1* /kinetics/chain/kinetics[19]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK* /kinetics/chain/kinetics[19]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK* /kinetics/chain/kinetics[19]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[19]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[19]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[19]/Ras-act-unphosph-raf /kinetics/chain/kinetics[19]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1/diff /kinetics/chain/kinetics[19]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1/diff /kinetics/chain/kinetics[19]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1 /kinetics/chain/kinetics[19]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1 /kinetics/chain/kinetics[19]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[19]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[19]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[19]/Ras-act-craf /kinetics/chain/kinetics[19]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[19]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[19]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1*/diff /kinetics/chain/kinetics[19]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1*/diff /kinetics/chain/kinetics[19]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1* /kinetics/chain/kinetics[19]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1* /kinetics/chain/kinetics[19]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[19]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[19]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[19]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK/diff /kinetics/chain/kinetics[19]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK/diff /kinetics/chain/kinetics[19]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK /kinetics/chain/kinetics[19]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK /kinetics/chain/kinetics[19]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[19]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[19]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[19]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK/diff /kinetics/chain/kinetics[19]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK/diff /kinetics/chain/kinetics[19]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK /kinetics/chain/kinetics[19]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK /kinetics/chain/kinetics[19]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[19]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[19]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1**/diff /kinetics/chain/kinetics[19]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1**/diff /kinetics/chain/kinetics[19]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1** /kinetics/chain/kinetics[19]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1** /kinetics/chain/kinetics[19]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[19]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[19]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[19]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[19]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[19]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[19]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[19]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[19]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[19]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK* /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK* /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK* /kinetics/chain/kinetics[19]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK* /kinetics/chain/kinetics[19]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[19]/Ras-act-unphosph-raf /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[19]/Ras-act-craf /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[19]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[19]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[19]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[18]/MKP-1/diff /kinetics/chain/kinetics[19]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[19]/MKP-1/diff /kinetics/chain/kinetics[19]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr /kinetics/chain/kinetics[19]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MKP-1 /kinetics/chain/kinetics[19]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK* /kinetics/chain/kinetics[19]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MKP-1 /kinetics/chain/kinetics[19]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[19]/MKP-1 /kinetics/chain/kinetics[19]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MKP-1 /kinetics/chain/kinetics[19]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1* /kinetics/chain/kinetics[19]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[19]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ras/GTP-Ras /kinetics/chain/kinetics[19]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[19]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[19]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[19]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[19]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/diff /kinetics/chain/kinetics[19]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/diff /kinetics/chain/kinetics[19]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1* /kinetics/chain/kinetics[19]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A /kinetics/chain/kinetics[19]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK* /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1** /kinetics/chain/kinetics[19]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A /kinetics/chain/kinetics[19]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A /kinetics/chain/kinetics[19]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A /kinetics/chain/kinetics[19]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF /kinetics/chain/kinetics[19]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ras/GEF* /kinetics/chain/kinetics[19]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[19]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[19]/Ras/dephosph-GEF /kinetics/chain/kinetics[19]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[19]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[19]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[19]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF/diff /kinetics/chain/kinetics[19]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF/diff /kinetics/chain/kinetics[19]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF /kinetics/chain/kinetics[19]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[19]/Ras/GDP-Ras /kinetics/chain/kinetics[19]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF /kinetics/chain/kinetics[19]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF /kinetics/chain/kinetics[19]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[19]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[19]/Ras/dephosph-GEF /kinetics/chain/kinetics[19]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[19]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[18]/Ras/GEF*/diff /kinetics/chain/kinetics[19]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[19]/Ras/GEF*/diff /kinetics/chain/kinetics[19]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/GEF* /kinetics/chain/kinetics[19]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[19]/Ras/GDP-Ras /kinetics/chain/kinetics[19]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/GEF* /kinetics/chain/kinetics[19]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/GEF* /kinetics/chain/kinetics[19]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ras-act-craf /kinetics/chain/kinetics[19]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[19]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[19]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[19]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[19]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[19]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[19]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[19]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[19]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[19]/Ras-act-unphosph-raf /kinetics/chain/kinetics[19]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[19]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[19]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[19]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/GTP-Ras /kinetics/chain/kinetics[19]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/GTP-Ras /kinetics/chain/kinetics[19]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[19]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[19]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[19]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[19]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[19]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[19]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[19]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[19]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[19]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[18]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[19]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[19]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[19]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/GDP-Ras /kinetics/chain/kinetics[19]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/GDP-Ras /kinetics/chain/kinetics[19]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ras/GTP-Ras /kinetics/chain/kinetics[19]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/GDP-Ras /kinetics/chain/kinetics[19]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ras/GAP* /kinetics/chain/kinetics[19]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/GAP /kinetics/chain/kinetics[19]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[19]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[19]/Ras/dephosph-GAP /kinetics/chain/kinetics[19]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/GAP*/diff /kinetics/chain/kinetics[19]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[19]/Ras/GAP*/diff /kinetics/chain/kinetics[19]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/GAP* /kinetics/chain/kinetics[19]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/GAP* /kinetics/chain/kinetics[19]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[19]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[19]/Ras/dephosph-GAP /kinetics/chain/kinetics[19]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[19]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[19]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[18]/Ras/GAP/diff /kinetics/chain/kinetics[19]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[19]/Ras/GAP/diff /kinetics/chain/kinetics[19]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/GTP-Ras /kinetics/chain/kinetics[19]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/GAP /kinetics/chain/kinetics[19]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[19]/Ras/GAP /kinetics/chain/kinetics[19]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/GAP /kinetics/chain/kinetics[19]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF /kinetics/chain/kinetics[19]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/CaM-GEF /kinetics/chain/kinetics[19]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 /kinetics/chain/kinetics[19]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[19]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[19]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[19]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[18]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[19]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[19]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[19]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/GDP-Ras /kinetics/chain/kinetics[19]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/CaM-GEF /kinetics/chain/kinetics[19]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[19]/Ras/CaM-GEF /kinetics/chain/kinetics[19]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/CaM-GEF /kinetics/chain/kinetics[19]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[19]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM/diff /kinetics/chain/kinetics[19]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[19]/CaM/CaM/diff /kinetics/chain/kinetics[19]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM /kinetics/chain/kinetics[19]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM /kinetics/chain/kinetics[19]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca3 /kinetics/chain/kinetics[19]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 /kinetics/chain/kinetics[19]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[19]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[19]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca3 /kinetics/chain/kinetics[19]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca3 /kinetics/chain/kinetics[19]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[19]/PKM/trigger_PKM /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 /kinetics/chain/kinetics[19]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 /kinetics/chain/kinetics[19]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/CaM/CaM /kinetics/chain/kinetics[19]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca /kinetics/chain/kinetics[19]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ca /kinetics/chain/kinetics[19]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[19]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[19]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca2 /kinetics/chain/kinetics[19]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca2 /kinetics/chain/kinetics[19]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca3 /kinetics/chain/kinetics[19]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca2 /kinetics/chain/kinetics[19]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca2 /kinetics/chain/kinetics[19]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[19]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[19]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[19]/Ca REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[19]/Ca REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[19]/Ca REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[19]/Ca REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[19]/Ca REAC A B addmsg /kinetics/chain/kinetics[19]/Ca_diff /kinetics/chain/kinetics[19]/Ca REAC B A addmsg /kinetics/chain/kinetics[18]/Ca/diff /kinetics/chain/kinetics[19]/Ca REAC B A addmsg /kinetics/chain/kinetics[19]/Ca/diff /kinetics/chain/kinetics[19]/Ca REAC A B addmsg /kinetics/chain/kinetics[19]/Ca /kinetics/chain/kinetics[19]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ca /kinetics/chain/kinetics[19]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1 /kinetics/chain/kinetics[19]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[19]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ras/GTP-Ras /kinetics/chain/kinetics[19]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKM/trigger_PKM /kinetics/chain/kinetics[19]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[18]/PKM/Ca_detector/diff /kinetics/chain/kinetics[19]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[19]/PKM/Ca_detector/diff /kinetics/chain/kinetics[19]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[19]/PKM/Ca_detector /kinetics/chain/kinetics[19]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKM/Ca_detector /kinetics/chain/kinetics[19]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[19]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[19]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[19]/PKM/turn_off_activator /kinetics/chain/kinetics[19]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[18]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[19]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[19]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[19]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[19]/PKM/PKM_synthesis /kinetics/chain/kinetics[19]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[19]/PKM/AA_pool /kinetics/chain/kinetics[19]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKM/PKM_synthesis /kinetics/chain/kinetics[19]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKM/PKM_synthesis /kinetics/chain/kinetics[19]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[19]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[19]/PKC/PKM-zeta /kinetics/chain/kinetics[19]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKM/degraded_PKM /kinetics/chain/kinetics[19]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKM/PKM_degradation /kinetics/chain/kinetics[19]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[19]/PKM/trigger_PKM /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[18]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[19]/PKM/PKM_activator /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[19]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[19]/PKM/turn_off_activator /kinetics/chain/kinetics[19]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[18]/PKM/PKM_activator/diff /kinetics/chain/kinetics[19]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[19]/PKM/PKM_activator/diff /kinetics/chain/kinetics[19]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[19]/PKM/PKM_activator /kinetics/chain/kinetics[19]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKM/PKM_activator /kinetics/chain/kinetics[19]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKM/PKM_synthesis /kinetics/chain/kinetics[19]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKM/PKM_activator /kinetics/chain/kinetics[19]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 /kinetics/chain/kinetics[19]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKM/Ca_detector /kinetics/chain/kinetics[19]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex /kinetics/chain/kinetics[19]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ca_diff /kinetics/chain/kinetics[19]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[19]/Ca /kinetics/chain/kinetics[19]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ca_input /kinetics/chain/kinetics[19]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[20]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[20]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[20]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[20]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[20]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca /kinetics/chain/kinetics[20]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca /kinetics/chain/kinetics[20]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ca /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[20]/DAG /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca /kinetics/chain/kinetics[20]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[20]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[20]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[20]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/DAG /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG /kinetics/chain/kinetics[20]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[20]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[20]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG /kinetics/chain/kinetics[20]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG /kinetics/chain/kinetics[20]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[20]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[20]/PKM/PKM_degradation /kinetics/chain/kinetics[20]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[20]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[20]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKM-zeta /kinetics/chain/kinetics[20]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKM-zeta /kinetics/chain/kinetics[20]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[20]/DAG REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG /kinetics/chain/kinetics[20]/DAG REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[20]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[20]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[20]/PKC/PKM-zeta /kinetics/chain/kinetics[20]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[20]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[20]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[20]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[20]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[20]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[20]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[20]/PKC-active /kinetics/chain/kinetics[20]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1 /kinetics/chain/kinetics[20]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC-active /kinetics/chain/kinetics[20]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[20]/Ras/GAP /kinetics/chain/kinetics[20]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC-active /kinetics/chain/kinetics[20]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF /kinetics/chain/kinetics[20]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[20]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[20]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[20]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[19]/MAPK*/diff /kinetics/chain/kinetics[20]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[20]/MAPK*/diff /kinetics/chain/kinetics[20]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[20]/MAPK* /kinetics/chain/kinetics[20]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1* /kinetics/chain/kinetics[20]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK* /kinetics/chain/kinetics[20]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK* /kinetics/chain/kinetics[20]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[20]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[20]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[20]/Ras-act-unphosph-raf /kinetics/chain/kinetics[20]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1/diff /kinetics/chain/kinetics[20]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1/diff /kinetics/chain/kinetics[20]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1 /kinetics/chain/kinetics[20]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1 /kinetics/chain/kinetics[20]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[20]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[20]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[20]/Ras-act-craf /kinetics/chain/kinetics[20]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[20]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[20]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1*/diff /kinetics/chain/kinetics[20]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1*/diff /kinetics/chain/kinetics[20]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1* /kinetics/chain/kinetics[20]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1* /kinetics/chain/kinetics[20]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[20]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[20]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[20]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK/diff /kinetics/chain/kinetics[20]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK/diff /kinetics/chain/kinetics[20]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK /kinetics/chain/kinetics[20]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK /kinetics/chain/kinetics[20]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[20]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[20]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[20]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK/diff /kinetics/chain/kinetics[20]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK/diff /kinetics/chain/kinetics[20]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK /kinetics/chain/kinetics[20]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK /kinetics/chain/kinetics[20]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[20]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[20]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1**/diff /kinetics/chain/kinetics[20]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1**/diff /kinetics/chain/kinetics[20]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1** /kinetics/chain/kinetics[20]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1** /kinetics/chain/kinetics[20]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[20]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[20]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[20]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[20]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[20]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[20]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[20]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[20]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[20]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK* /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK* /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK* /kinetics/chain/kinetics[20]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK* /kinetics/chain/kinetics[20]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[20]/Ras-act-unphosph-raf /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[20]/Ras-act-craf /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[20]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[20]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[20]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[19]/MKP-1/diff /kinetics/chain/kinetics[20]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[20]/MKP-1/diff /kinetics/chain/kinetics[20]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr /kinetics/chain/kinetics[20]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MKP-1 /kinetics/chain/kinetics[20]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK* /kinetics/chain/kinetics[20]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MKP-1 /kinetics/chain/kinetics[20]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[20]/MKP-1 /kinetics/chain/kinetics[20]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MKP-1 /kinetics/chain/kinetics[20]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1* /kinetics/chain/kinetics[20]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[20]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ras/GTP-Ras /kinetics/chain/kinetics[20]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[20]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[20]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[20]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[20]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/diff /kinetics/chain/kinetics[20]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/diff /kinetics/chain/kinetics[20]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1* /kinetics/chain/kinetics[20]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A /kinetics/chain/kinetics[20]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK* /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1** /kinetics/chain/kinetics[20]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A /kinetics/chain/kinetics[20]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A /kinetics/chain/kinetics[20]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A /kinetics/chain/kinetics[20]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF /kinetics/chain/kinetics[20]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ras/GEF* /kinetics/chain/kinetics[20]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[20]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[20]/Ras/dephosph-GEF /kinetics/chain/kinetics[20]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[20]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[20]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[20]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF/diff /kinetics/chain/kinetics[20]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF/diff /kinetics/chain/kinetics[20]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF /kinetics/chain/kinetics[20]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[20]/Ras/GDP-Ras /kinetics/chain/kinetics[20]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF /kinetics/chain/kinetics[20]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF /kinetics/chain/kinetics[20]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[20]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[20]/Ras/dephosph-GEF /kinetics/chain/kinetics[20]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[20]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[19]/Ras/GEF*/diff /kinetics/chain/kinetics[20]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[20]/Ras/GEF*/diff /kinetics/chain/kinetics[20]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/GEF* /kinetics/chain/kinetics[20]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[20]/Ras/GDP-Ras /kinetics/chain/kinetics[20]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/GEF* /kinetics/chain/kinetics[20]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/GEF* /kinetics/chain/kinetics[20]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ras-act-craf /kinetics/chain/kinetics[20]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[20]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[20]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[20]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[20]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[20]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[20]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[20]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[20]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[20]/Ras-act-unphosph-raf /kinetics/chain/kinetics[20]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[20]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[20]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[20]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/GTP-Ras /kinetics/chain/kinetics[20]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/GTP-Ras /kinetics/chain/kinetics[20]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[20]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[20]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[20]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[20]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[20]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[20]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[20]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[20]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[20]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[19]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[20]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[20]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[20]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/GDP-Ras /kinetics/chain/kinetics[20]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/GDP-Ras /kinetics/chain/kinetics[20]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ras/GTP-Ras /kinetics/chain/kinetics[20]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/GDP-Ras /kinetics/chain/kinetics[20]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ras/GAP* /kinetics/chain/kinetics[20]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/GAP /kinetics/chain/kinetics[20]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[20]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[20]/Ras/dephosph-GAP /kinetics/chain/kinetics[20]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/GAP*/diff /kinetics/chain/kinetics[20]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[20]/Ras/GAP*/diff /kinetics/chain/kinetics[20]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/GAP* /kinetics/chain/kinetics[20]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/GAP* /kinetics/chain/kinetics[20]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[20]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[20]/Ras/dephosph-GAP /kinetics/chain/kinetics[20]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[20]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[20]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[19]/Ras/GAP/diff /kinetics/chain/kinetics[20]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[20]/Ras/GAP/diff /kinetics/chain/kinetics[20]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/GTP-Ras /kinetics/chain/kinetics[20]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/GAP /kinetics/chain/kinetics[20]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[20]/Ras/GAP /kinetics/chain/kinetics[20]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/GAP /kinetics/chain/kinetics[20]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF /kinetics/chain/kinetics[20]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/CaM-GEF /kinetics/chain/kinetics[20]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 /kinetics/chain/kinetics[20]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[20]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[20]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[20]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[19]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[20]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[20]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[20]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/GDP-Ras /kinetics/chain/kinetics[20]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/CaM-GEF /kinetics/chain/kinetics[20]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[20]/Ras/CaM-GEF /kinetics/chain/kinetics[20]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/CaM-GEF /kinetics/chain/kinetics[20]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[20]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM/diff /kinetics/chain/kinetics[20]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[20]/CaM/CaM/diff /kinetics/chain/kinetics[20]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM /kinetics/chain/kinetics[20]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM /kinetics/chain/kinetics[20]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca3 /kinetics/chain/kinetics[20]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 /kinetics/chain/kinetics[20]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[20]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[20]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca3 /kinetics/chain/kinetics[20]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca3 /kinetics/chain/kinetics[20]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[20]/PKM/trigger_PKM /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 /kinetics/chain/kinetics[20]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca4 /kinetics/chain/kinetics[20]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/CaM/CaM /kinetics/chain/kinetics[20]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca /kinetics/chain/kinetics[20]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ca /kinetics/chain/kinetics[20]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[20]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[20]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca2 /kinetics/chain/kinetics[20]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca2 /kinetics/chain/kinetics[20]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca3 /kinetics/chain/kinetics[20]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca2 /kinetics/chain/kinetics[20]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca2 /kinetics/chain/kinetics[20]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[20]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[20]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[20]/Ca REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[20]/Ca REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[20]/Ca REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[20]/Ca REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[20]/Ca REAC A B addmsg /kinetics/chain/kinetics[20]/Ca_diff /kinetics/chain/kinetics[20]/Ca REAC B A addmsg /kinetics/chain/kinetics[19]/Ca/diff /kinetics/chain/kinetics[20]/Ca REAC B A addmsg /kinetics/chain/kinetics[20]/Ca/diff /kinetics/chain/kinetics[20]/Ca REAC A B addmsg /kinetics/chain/kinetics[20]/Ca /kinetics/chain/kinetics[20]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ca /kinetics/chain/kinetics[20]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1 /kinetics/chain/kinetics[20]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[20]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ras/GTP-Ras /kinetics/chain/kinetics[20]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKM/trigger_PKM /kinetics/chain/kinetics[20]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[19]/PKM/Ca_detector/diff /kinetics/chain/kinetics[20]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[20]/PKM/Ca_detector/diff /kinetics/chain/kinetics[20]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[20]/PKM/Ca_detector /kinetics/chain/kinetics[20]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKM/Ca_detector /kinetics/chain/kinetics[20]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[20]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[20]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[20]/PKM/turn_off_activator /kinetics/chain/kinetics[20]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[19]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[20]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[20]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[20]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[20]/PKM/PKM_synthesis /kinetics/chain/kinetics[20]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[20]/PKM/AA_pool /kinetics/chain/kinetics[20]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKM/PKM_synthesis /kinetics/chain/kinetics[20]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKM/PKM_synthesis /kinetics/chain/kinetics[20]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[20]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[20]/PKC/PKM-zeta /kinetics/chain/kinetics[20]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKM/degraded_PKM /kinetics/chain/kinetics[20]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKM/PKM_degradation /kinetics/chain/kinetics[20]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[20]/PKM/trigger_PKM /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[19]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[20]/PKM/PKM_activator /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[20]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[20]/PKM/turn_off_activator /kinetics/chain/kinetics[20]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[19]/PKM/PKM_activator/diff /kinetics/chain/kinetics[20]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[20]/PKM/PKM_activator/diff /kinetics/chain/kinetics[20]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[20]/PKM/PKM_activator /kinetics/chain/kinetics[20]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKM/PKM_activator /kinetics/chain/kinetics[20]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKM/PKM_synthesis /kinetics/chain/kinetics[20]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKM/PKM_activator /kinetics/chain/kinetics[20]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 /kinetics/chain/kinetics[20]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKM/Ca_detector /kinetics/chain/kinetics[20]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex /kinetics/chain/kinetics[20]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ca_diff /kinetics/chain/kinetics[20]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[20]/Ca /kinetics/chain/kinetics[20]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ca_input /kinetics/chain/kinetics[20]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[21]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[21]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[21]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[21]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[21]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca /kinetics/chain/kinetics[21]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca /kinetics/chain/kinetics[21]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ca /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca /kinetics/chain/kinetics[21]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[21]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[21]/DAG /kinetics/chain/kinetics[21]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca /kinetics/chain/kinetics[21]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[21]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[21]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[21]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/DAG /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG /kinetics/chain/kinetics[21]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[21]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[21]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG /kinetics/chain/kinetics[21]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG /kinetics/chain/kinetics[21]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[21]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[21]/PKM/PKM_degradation /kinetics/chain/kinetics[21]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[21]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[21]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKM-zeta /kinetics/chain/kinetics[21]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKM-zeta /kinetics/chain/kinetics[21]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[21]/DAG REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG /kinetics/chain/kinetics[21]/DAG REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[21]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[21]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[21]/PKC/PKM-zeta /kinetics/chain/kinetics[21]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[21]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[21]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[21]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[21]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[21]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[21]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[21]/PKC-active /kinetics/chain/kinetics[21]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1 /kinetics/chain/kinetics[21]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC-active /kinetics/chain/kinetics[21]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[21]/Ras/GAP /kinetics/chain/kinetics[21]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC-active /kinetics/chain/kinetics[21]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF /kinetics/chain/kinetics[21]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[21]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[21]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[21]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[20]/MAPK*/diff /kinetics/chain/kinetics[21]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[21]/MAPK*/diff /kinetics/chain/kinetics[21]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[21]/MAPK* /kinetics/chain/kinetics[21]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1* /kinetics/chain/kinetics[21]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK* /kinetics/chain/kinetics[21]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK* /kinetics/chain/kinetics[21]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[21]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[21]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[21]/Ras-act-unphosph-raf /kinetics/chain/kinetics[21]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1/diff /kinetics/chain/kinetics[21]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1/diff /kinetics/chain/kinetics[21]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1 /kinetics/chain/kinetics[21]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1 /kinetics/chain/kinetics[21]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[21]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[21]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[21]/Ras-act-craf /kinetics/chain/kinetics[21]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[21]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[21]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1*/diff /kinetics/chain/kinetics[21]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1*/diff /kinetics/chain/kinetics[21]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1* /kinetics/chain/kinetics[21]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1* /kinetics/chain/kinetics[21]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[21]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[21]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[21]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK/diff /kinetics/chain/kinetics[21]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK/diff /kinetics/chain/kinetics[21]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK /kinetics/chain/kinetics[21]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK /kinetics/chain/kinetics[21]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[21]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[21]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[21]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK/diff /kinetics/chain/kinetics[21]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK/diff /kinetics/chain/kinetics[21]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK /kinetics/chain/kinetics[21]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK /kinetics/chain/kinetics[21]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[21]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[21]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1**/diff /kinetics/chain/kinetics[21]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1**/diff /kinetics/chain/kinetics[21]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1** /kinetics/chain/kinetics[21]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1** /kinetics/chain/kinetics[21]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[21]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[21]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[21]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[21]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[21]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[21]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[21]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[21]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[21]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK* /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK* /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK* /kinetics/chain/kinetics[21]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK* /kinetics/chain/kinetics[21]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[21]/Ras-act-unphosph-raf /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[21]/Ras-act-craf /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[21]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[21]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[21]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[20]/MKP-1/diff /kinetics/chain/kinetics[21]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[21]/MKP-1/diff /kinetics/chain/kinetics[21]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr /kinetics/chain/kinetics[21]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MKP-1 /kinetics/chain/kinetics[21]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK* /kinetics/chain/kinetics[21]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MKP-1 /kinetics/chain/kinetics[21]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[21]/MKP-1 /kinetics/chain/kinetics[21]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MKP-1 /kinetics/chain/kinetics[21]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1* /kinetics/chain/kinetics[21]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[21]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ras/GTP-Ras /kinetics/chain/kinetics[21]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[21]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[21]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[21]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[21]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/diff /kinetics/chain/kinetics[21]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/diff /kinetics/chain/kinetics[21]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1* /kinetics/chain/kinetics[21]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A /kinetics/chain/kinetics[21]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK* /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1** /kinetics/chain/kinetics[21]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A /kinetics/chain/kinetics[21]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A /kinetics/chain/kinetics[21]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A /kinetics/chain/kinetics[21]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF /kinetics/chain/kinetics[21]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ras/GEF* /kinetics/chain/kinetics[21]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[21]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[21]/Ras/dephosph-GEF /kinetics/chain/kinetics[21]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[21]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[21]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[21]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF/diff /kinetics/chain/kinetics[21]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF/diff /kinetics/chain/kinetics[21]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF /kinetics/chain/kinetics[21]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[21]/Ras/GDP-Ras /kinetics/chain/kinetics[21]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF /kinetics/chain/kinetics[21]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF /kinetics/chain/kinetics[21]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[21]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[21]/Ras/dephosph-GEF /kinetics/chain/kinetics[21]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[21]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[20]/Ras/GEF*/diff /kinetics/chain/kinetics[21]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[21]/Ras/GEF*/diff /kinetics/chain/kinetics[21]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/GEF* /kinetics/chain/kinetics[21]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[21]/Ras/GDP-Ras /kinetics/chain/kinetics[21]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/GEF* /kinetics/chain/kinetics[21]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/GEF* /kinetics/chain/kinetics[21]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ras-act-craf /kinetics/chain/kinetics[21]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[21]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[21]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[21]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[21]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[21]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[21]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[21]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[21]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[21]/Ras-act-unphosph-raf /kinetics/chain/kinetics[21]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[21]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[21]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[21]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/GTP-Ras /kinetics/chain/kinetics[21]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/GTP-Ras /kinetics/chain/kinetics[21]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[21]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[21]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[21]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[21]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[21]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[21]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[21]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[21]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[21]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[20]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[21]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[21]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[21]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/GDP-Ras /kinetics/chain/kinetics[21]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/GDP-Ras /kinetics/chain/kinetics[21]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ras/GTP-Ras /kinetics/chain/kinetics[21]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/GDP-Ras /kinetics/chain/kinetics[21]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ras/GAP* /kinetics/chain/kinetics[21]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/GAP /kinetics/chain/kinetics[21]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[21]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[21]/Ras/dephosph-GAP /kinetics/chain/kinetics[21]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/GAP*/diff /kinetics/chain/kinetics[21]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[21]/Ras/GAP*/diff /kinetics/chain/kinetics[21]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/GAP* /kinetics/chain/kinetics[21]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/GAP* /kinetics/chain/kinetics[21]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[21]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[21]/Ras/dephosph-GAP /kinetics/chain/kinetics[21]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[21]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[21]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[20]/Ras/GAP/diff /kinetics/chain/kinetics[21]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[21]/Ras/GAP/diff /kinetics/chain/kinetics[21]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/GTP-Ras /kinetics/chain/kinetics[21]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/GAP /kinetics/chain/kinetics[21]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[21]/Ras/GAP /kinetics/chain/kinetics[21]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/GAP /kinetics/chain/kinetics[21]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF /kinetics/chain/kinetics[21]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/CaM-GEF /kinetics/chain/kinetics[21]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca4 /kinetics/chain/kinetics[21]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[21]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[21]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[21]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[20]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[21]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[21]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[21]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/GDP-Ras /kinetics/chain/kinetics[21]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/CaM-GEF /kinetics/chain/kinetics[21]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[21]/Ras/CaM-GEF /kinetics/chain/kinetics[21]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/CaM-GEF /kinetics/chain/kinetics[21]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[21]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM/diff /kinetics/chain/kinetics[21]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[21]/CaM/CaM/diff /kinetics/chain/kinetics[21]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM /kinetics/chain/kinetics[21]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM /kinetics/chain/kinetics[21]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca3 /kinetics/chain/kinetics[21]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca4 /kinetics/chain/kinetics[21]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[21]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[21]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca3 /kinetics/chain/kinetics[21]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca3 /kinetics/chain/kinetics[21]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[21]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[21]/PKM/trigger_PKM /kinetics/chain/kinetics[21]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[21]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[21]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca4 /kinetics/chain/kinetics[21]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca4 /kinetics/chain/kinetics[21]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/CaM/CaM /kinetics/chain/kinetics[21]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca /kinetics/chain/kinetics[21]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ca /kinetics/chain/kinetics[21]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[21]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[21]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca2 /kinetics/chain/kinetics[21]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca2 /kinetics/chain/kinetics[21]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca3 /kinetics/chain/kinetics[21]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca2 /kinetics/chain/kinetics[21]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca2 /kinetics/chain/kinetics[21]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[21]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[21]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[21]/Ca REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[21]/Ca REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[21]/Ca REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[21]/Ca REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[21]/Ca REAC A B addmsg /kinetics/chain/kinetics[21]/Ca_diff /kinetics/chain/kinetics[21]/Ca REAC B A addmsg /kinetics/chain/kinetics[20]/Ca/diff /kinetics/chain/kinetics[21]/Ca REAC B A addmsg /kinetics/chain/kinetics[21]/Ca/diff /kinetics/chain/kinetics[21]/Ca REAC A B addmsg /kinetics/chain/kinetics[21]/Ca /kinetics/chain/kinetics[21]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ca /kinetics/chain/kinetics[21]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1 /kinetics/chain/kinetics[21]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[21]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ras/GTP-Ras /kinetics/chain/kinetics[21]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKM/trigger_PKM /kinetics/chain/kinetics[21]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[20]/PKM/Ca_detector/diff /kinetics/chain/kinetics[21]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[21]/PKM/Ca_detector/diff /kinetics/chain/kinetics[21]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[21]/PKM/Ca_detector /kinetics/chain/kinetics[21]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKM/Ca_detector /kinetics/chain/kinetics[21]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[21]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[21]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[21]/PKM/turn_off_activator /kinetics/chain/kinetics[21]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[20]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[21]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[21]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[21]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[21]/PKM/PKM_synthesis /kinetics/chain/kinetics[21]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[21]/PKM/AA_pool /kinetics/chain/kinetics[21]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKM/PKM_synthesis /kinetics/chain/kinetics[21]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKM/PKM_synthesis /kinetics/chain/kinetics[21]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[21]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[21]/PKC/PKM-zeta /kinetics/chain/kinetics[21]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKM/degraded_PKM /kinetics/chain/kinetics[21]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKM/PKM_degradation /kinetics/chain/kinetics[21]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[21]/PKM/trigger_PKM /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[20]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[21]/PKM/PKM_activator /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[21]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[21]/PKM/turn_off_activator /kinetics/chain/kinetics[21]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[20]/PKM/PKM_activator/diff /kinetics/chain/kinetics[21]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[21]/PKM/PKM_activator/diff /kinetics/chain/kinetics[21]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[21]/PKM/PKM_activator /kinetics/chain/kinetics[21]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKM/PKM_activator /kinetics/chain/kinetics[21]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKM/PKM_synthesis /kinetics/chain/kinetics[21]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKM/PKM_activator /kinetics/chain/kinetics[21]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca4 /kinetics/chain/kinetics[21]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKM/Ca_detector /kinetics/chain/kinetics[21]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex /kinetics/chain/kinetics[21]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ca_diff /kinetics/chain/kinetics[21]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[21]/Ca /kinetics/chain/kinetics[21]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ca_input /kinetics/chain/kinetics[21]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[22]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[22]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[22]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[22]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[22]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca /kinetics/chain/kinetics[22]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca /kinetics/chain/kinetics[22]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ca /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca /kinetics/chain/kinetics[22]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[22]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[22]/DAG /kinetics/chain/kinetics[22]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca /kinetics/chain/kinetics[22]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[22]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[22]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[22]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/DAG /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG /kinetics/chain/kinetics[22]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[22]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[22]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG /kinetics/chain/kinetics[22]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG /kinetics/chain/kinetics[22]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[22]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[22]/PKM/PKM_degradation /kinetics/chain/kinetics[22]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[22]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[22]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKM-zeta /kinetics/chain/kinetics[22]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKM-zeta /kinetics/chain/kinetics[22]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[22]/DAG REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG /kinetics/chain/kinetics[22]/DAG REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[22]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[22]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[22]/PKC/PKM-zeta /kinetics/chain/kinetics[22]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[22]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[22]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[22]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[22]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[22]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[22]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[22]/PKC-active /kinetics/chain/kinetics[22]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1 /kinetics/chain/kinetics[22]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC-active /kinetics/chain/kinetics[22]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[22]/Ras/GAP /kinetics/chain/kinetics[22]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC-active /kinetics/chain/kinetics[22]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF /kinetics/chain/kinetics[22]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[22]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[22]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[22]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[21]/MAPK*/diff /kinetics/chain/kinetics[22]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[22]/MAPK*/diff /kinetics/chain/kinetics[22]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[22]/MAPK* /kinetics/chain/kinetics[22]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1* /kinetics/chain/kinetics[22]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK* /kinetics/chain/kinetics[22]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK* /kinetics/chain/kinetics[22]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[22]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[22]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[22]/Ras-act-unphosph-raf /kinetics/chain/kinetics[22]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1/diff /kinetics/chain/kinetics[22]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1/diff /kinetics/chain/kinetics[22]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1 /kinetics/chain/kinetics[22]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1 /kinetics/chain/kinetics[22]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[22]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[22]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[22]/Ras-act-craf /kinetics/chain/kinetics[22]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[22]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[22]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1*/diff /kinetics/chain/kinetics[22]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1*/diff /kinetics/chain/kinetics[22]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1* /kinetics/chain/kinetics[22]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1* /kinetics/chain/kinetics[22]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[22]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[22]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[22]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK/diff /kinetics/chain/kinetics[22]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK/diff /kinetics/chain/kinetics[22]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK /kinetics/chain/kinetics[22]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK /kinetics/chain/kinetics[22]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[22]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[22]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[22]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK/diff /kinetics/chain/kinetics[22]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK/diff /kinetics/chain/kinetics[22]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK /kinetics/chain/kinetics[22]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPK /kinetics/chain/kinetics[22]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[22]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[22]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1**/diff /kinetics/chain/kinetics[22]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1**/diff /kinetics/chain/kinetics[22]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1** /kinetics/chain/kinetics[22]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1** /kinetics/chain/kinetics[22]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[22]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[22]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[22]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[22]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[22]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[22]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[22]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[22]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[22]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK* /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK* /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK* /kinetics/chain/kinetics[22]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK* /kinetics/chain/kinetics[22]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[22]/Ras-act-unphosph-raf /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[22]/Ras-act-craf /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[22]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[22]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[22]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[21]/MKP-1/diff /kinetics/chain/kinetics[22]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[22]/MKP-1/diff /kinetics/chain/kinetics[22]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr /kinetics/chain/kinetics[22]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MKP-1 /kinetics/chain/kinetics[22]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK* /kinetics/chain/kinetics[22]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MKP-1 /kinetics/chain/kinetics[22]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[22]/MKP-1 /kinetics/chain/kinetics[22]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MKP-1 /kinetics/chain/kinetics[22]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1* /kinetics/chain/kinetics[22]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[22]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ras/GTP-Ras /kinetics/chain/kinetics[22]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[22]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[22]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[22]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[22]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/diff /kinetics/chain/kinetics[22]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/diff /kinetics/chain/kinetics[22]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1* /kinetics/chain/kinetics[22]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A /kinetics/chain/kinetics[22]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK* /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1** /kinetics/chain/kinetics[22]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A /kinetics/chain/kinetics[22]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A /kinetics/chain/kinetics[22]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A /kinetics/chain/kinetics[22]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF /kinetics/chain/kinetics[22]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ras/GEF* /kinetics/chain/kinetics[22]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[22]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[22]/Ras/dephosph-GEF /kinetics/chain/kinetics[22]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[22]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[22]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[22]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF/diff /kinetics/chain/kinetics[22]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF/diff /kinetics/chain/kinetics[22]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF /kinetics/chain/kinetics[22]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[22]/Ras/GDP-Ras /kinetics/chain/kinetics[22]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF /kinetics/chain/kinetics[22]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/inact-GEF /kinetics/chain/kinetics[22]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[22]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[22]/Ras/dephosph-GEF /kinetics/chain/kinetics[22]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[22]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[21]/Ras/GEF*/diff /kinetics/chain/kinetics[22]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[22]/Ras/GEF*/diff /kinetics/chain/kinetics[22]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/GEF* /kinetics/chain/kinetics[22]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[22]/Ras/GDP-Ras /kinetics/chain/kinetics[22]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/GEF* /kinetics/chain/kinetics[22]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/GEF* /kinetics/chain/kinetics[22]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ras-act-craf /kinetics/chain/kinetics[22]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[22]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[22]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[22]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[22]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[22]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[22]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[22]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[22]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[22]/Ras-act-unphosph-raf /kinetics/chain/kinetics[22]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[22]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[22]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[22]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/GTP-Ras /kinetics/chain/kinetics[22]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/GTP-Ras /kinetics/chain/kinetics[22]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[22]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[22]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[22]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[22]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[22]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[22]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[22]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[22]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[22]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[21]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[22]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[22]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[22]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/GDP-Ras /kinetics/chain/kinetics[22]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/GDP-Ras /kinetics/chain/kinetics[22]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ras/GTP-Ras /kinetics/chain/kinetics[22]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/GDP-Ras /kinetics/chain/kinetics[22]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ras/GAP* /kinetics/chain/kinetics[22]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/GAP /kinetics/chain/kinetics[22]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[22]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[22]/Ras/dephosph-GAP /kinetics/chain/kinetics[22]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/GAP*/diff /kinetics/chain/kinetics[22]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[22]/Ras/GAP*/diff /kinetics/chain/kinetics[22]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/GAP* /kinetics/chain/kinetics[22]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/GAP* /kinetics/chain/kinetics[22]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[22]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[22]/Ras/dephosph-GAP /kinetics/chain/kinetics[22]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[22]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[22]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[21]/Ras/GAP/diff /kinetics/chain/kinetics[22]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[22]/Ras/GAP/diff /kinetics/chain/kinetics[22]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/GTP-Ras /kinetics/chain/kinetics[22]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/GAP /kinetics/chain/kinetics[22]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[22]/Ras/GAP /kinetics/chain/kinetics[22]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/GAP /kinetics/chain/kinetics[22]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF /kinetics/chain/kinetics[22]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/CaM-GEF /kinetics/chain/kinetics[22]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca4 /kinetics/chain/kinetics[22]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[22]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[22]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[22]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[21]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[22]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[22]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[22]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/GDP-Ras /kinetics/chain/kinetics[22]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/CaM-GEF /kinetics/chain/kinetics[22]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[22]/Ras/CaM-GEF /kinetics/chain/kinetics[22]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/CaM-GEF /kinetics/chain/kinetics[22]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[22]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM/diff /kinetics/chain/kinetics[22]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[22]/CaM/CaM/diff /kinetics/chain/kinetics[22]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM /kinetics/chain/kinetics[22]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM /kinetics/chain/kinetics[22]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca3 /kinetics/chain/kinetics[22]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca4 /kinetics/chain/kinetics[22]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[22]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[22]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca3 /kinetics/chain/kinetics[22]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca3 /kinetics/chain/kinetics[22]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[22]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[22]/PKM/trigger_PKM /kinetics/chain/kinetics[22]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[22]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[22]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca4 /kinetics/chain/kinetics[22]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca4 /kinetics/chain/kinetics[22]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/CaM/CaM /kinetics/chain/kinetics[22]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca /kinetics/chain/kinetics[22]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ca /kinetics/chain/kinetics[22]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[22]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[22]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca2 /kinetics/chain/kinetics[22]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca2 /kinetics/chain/kinetics[22]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca3 /kinetics/chain/kinetics[22]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca2 /kinetics/chain/kinetics[22]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca2 /kinetics/chain/kinetics[22]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[22]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[22]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[22]/Ca REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[22]/Ca REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[22]/Ca REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[22]/Ca REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[22]/Ca REAC A B addmsg /kinetics/chain/kinetics[22]/Ca_diff /kinetics/chain/kinetics[22]/Ca REAC B A addmsg /kinetics/chain/kinetics[21]/Ca/diff /kinetics/chain/kinetics[22]/Ca REAC B A addmsg /kinetics/chain/kinetics[22]/Ca/diff /kinetics/chain/kinetics[22]/Ca REAC A B addmsg /kinetics/chain/kinetics[22]/Ca /kinetics/chain/kinetics[22]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ca /kinetics/chain/kinetics[22]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1 /kinetics/chain/kinetics[22]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[22]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ras/GTP-Ras /kinetics/chain/kinetics[22]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKM/trigger_PKM /kinetics/chain/kinetics[22]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[21]/PKM/Ca_detector/diff /kinetics/chain/kinetics[22]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[22]/PKM/Ca_detector/diff /kinetics/chain/kinetics[22]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[22]/PKM/Ca_detector /kinetics/chain/kinetics[22]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKM/Ca_detector /kinetics/chain/kinetics[22]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[22]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[22]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[22]/PKM/turn_off_activator /kinetics/chain/kinetics[22]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[21]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[22]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[22]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[22]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[22]/PKM/PKM_synthesis /kinetics/chain/kinetics[22]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[22]/PKM/AA_pool /kinetics/chain/kinetics[22]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKM/PKM_synthesis /kinetics/chain/kinetics[22]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKM/PKM_synthesis /kinetics/chain/kinetics[22]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[22]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[22]/PKC/PKM-zeta /kinetics/chain/kinetics[22]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKM/degraded_PKM /kinetics/chain/kinetics[22]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKM/PKM_degradation /kinetics/chain/kinetics[22]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[22]/PKM/trigger_PKM /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[21]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[22]/PKM/PKM_activator /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[22]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[22]/PKM/turn_off_activator /kinetics/chain/kinetics[22]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[21]/PKM/PKM_activator/diff /kinetics/chain/kinetics[22]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[22]/PKM/PKM_activator/diff /kinetics/chain/kinetics[22]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[22]/PKM/PKM_activator /kinetics/chain/kinetics[22]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKM/PKM_activator /kinetics/chain/kinetics[22]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKM/PKM_synthesis /kinetics/chain/kinetics[22]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKM/PKM_activator /kinetics/chain/kinetics[22]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca4 /kinetics/chain/kinetics[22]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKM/Ca_detector /kinetics/chain/kinetics[22]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex /kinetics/chain/kinetics[22]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ca_diff /kinetics/chain/kinetics[22]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[22]/Ca /kinetics/chain/kinetics[22]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ca_input /kinetics/chain/kinetics[22]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[23]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[23]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[23]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[23]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[23]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca /kinetics/chain/kinetics[23]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PKC/PKC-Ca /kinetics/chain/kinetics[23]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ca /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca /kinetics/chain/kinetics[23]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[23]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[23]/DAG /kinetics/chain/kinetics[23]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca /kinetics/chain/kinetics[23]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[23]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[23]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[23]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[23]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[23]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[23]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[23]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[23]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[23]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[23]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[23]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[23]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[23]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[23]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[23]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[23]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[23]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[23]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[23]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/DAG /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG /kinetics/chain/kinetics[23]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[23]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[23]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG /kinetics/chain/kinetics[23]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PKC/PKC-DAG /kinetics/chain/kinetics[23]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PKC/PKC-cytosolic /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[23]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[23]/PKM/PKM_degradation /kinetics/chain/kinetics[23]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[23]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[23]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[23]/PKC/PKM-zeta /kinetics/chain/kinetics[23]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PKC/PKM-zeta /kinetics/chain/kinetics[23]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[23]/DAG REAC A B addmsg /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG /kinetics/chain/kinetics[23]/DAG REAC A B addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[23]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[23]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[23]/PKC/PKM-zeta /kinetics/chain/kinetics[23]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[23]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[23]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[23]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[23]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[23]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[23]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[23]/PKC-active /kinetics/chain/kinetics[23]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1 /kinetics/chain/kinetics[23]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC-active /kinetics/chain/kinetics[23]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[23]/Ras/GAP /kinetics/chain/kinetics[23]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC-active /kinetics/chain/kinetics[23]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[23]/Ras/inact-GEF /kinetics/chain/kinetics[23]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[23]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[23]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[23]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[23]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[22]/MAPK*/diff /kinetics/chain/kinetics[23]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[23]/MAPK*/diff /kinetics/chain/kinetics[23]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[23]/MAPK* /kinetics/chain/kinetics[23]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1* /kinetics/chain/kinetics[23]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK* /kinetics/chain/kinetics[23]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/MAPK* /kinetics/chain/kinetics[23]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[23]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[23]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[23]/Ras-act-unphosph-raf /kinetics/chain/kinetics[23]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1/diff /kinetics/chain/kinetics[23]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1/diff /kinetics/chain/kinetics[23]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1 /kinetics/chain/kinetics[23]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/MAPK/craf-1 /kinetics/chain/kinetics[23]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[23]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[23]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[23]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[23]/Ras-act-craf /kinetics/chain/kinetics[23]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[23]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[23]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1*/diff /kinetics/chain/kinetics[23]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1*/diff /kinetics/chain/kinetics[23]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1* /kinetics/chain/kinetics[23]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/MAPK/craf-1* /kinetics/chain/kinetics[23]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[23]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[23]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[23]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK/diff /kinetics/chain/kinetics[23]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK/diff /kinetics/chain/kinetics[23]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK /kinetics/chain/kinetics[23]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/MAPK/MAPKK /kinetics/chain/kinetics[23]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[23]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[23]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[23]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK/diff /kinetics/chain/kinetics[23]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[23]/MAPK/MAPK/diff /kinetics/chain/kinetics[23]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[23]/MAPK/MAPK /kinetics/chain/kinetics[23]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/MAPK/MAPK /kinetics/chain/kinetics[23]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[23]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[23]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1**/diff /kinetics/chain/kinetics[23]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1**/diff /kinetics/chain/kinetics[23]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1** /kinetics/chain/kinetics[23]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/MAPK/craf-1** /kinetics/chain/kinetics[23]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[23]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[23]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/MAPK/MAPK-tyr /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[23]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[23]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[23]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[23]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[23]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[23]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[23]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[23]/MAPK/MAPK /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK* /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK* /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK* /kinetics/chain/kinetics[23]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/MAPK/MAPKK* /kinetics/chain/kinetics[23]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/MAPK/MAPKK-ser /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[23]/Ras-act-unphosph-raf /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[23]/Ras-act-craf /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[23]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[23]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[23]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[22]/MKP-1/diff /kinetics/chain/kinetics[23]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[23]/MKP-1/diff /kinetics/chain/kinetics[23]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr /kinetics/chain/kinetics[23]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MKP-1 /kinetics/chain/kinetics[23]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK* /kinetics/chain/kinetics[23]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MKP-1 /kinetics/chain/kinetics[23]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[23]/MKP-1 /kinetics/chain/kinetics[23]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/MKP-1 /kinetics/chain/kinetics[23]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1* /kinetics/chain/kinetics[23]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[23]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ras/GTP-Ras /kinetics/chain/kinetics[23]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[23]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[23]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[23]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[23]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/diff /kinetics/chain/kinetics[23]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/diff /kinetics/chain/kinetics[23]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1* /kinetics/chain/kinetics[23]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A /kinetics/chain/kinetics[23]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK* /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1** /kinetics/chain/kinetics[23]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A /kinetics/chain/kinetics[23]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A /kinetics/chain/kinetics[23]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PPhosphatase2A /kinetics/chain/kinetics[23]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ras/inact-GEF /kinetics/chain/kinetics[23]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ras/GEF* /kinetics/chain/kinetics[23]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[23]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[23]/Ras/dephosph-GEF /kinetics/chain/kinetics[23]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[23]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[23]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[23]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF/diff /kinetics/chain/kinetics[23]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/inact-GEF/diff /kinetics/chain/kinetics[23]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[23]/Ras/inact-GEF /kinetics/chain/kinetics[23]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[23]/Ras/GDP-Ras /kinetics/chain/kinetics[23]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/inact-GEF /kinetics/chain/kinetics[23]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/Ras/inact-GEF /kinetics/chain/kinetics[23]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[23]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[23]/Ras/dephosph-GEF /kinetics/chain/kinetics[23]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[23]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[23]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[22]/Ras/GEF*/diff /kinetics/chain/kinetics[23]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/GEF*/diff /kinetics/chain/kinetics[23]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[23]/Ras/GEF* /kinetics/chain/kinetics[23]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[23]/Ras/GDP-Ras /kinetics/chain/kinetics[23]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/GEF* /kinetics/chain/kinetics[23]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/Ras/GEF* /kinetics/chain/kinetics[23]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ras-act-craf /kinetics/chain/kinetics[23]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[23]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[23]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[23]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[23]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[23]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[23]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[23]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[23]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[23]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[23]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[23]/Ras-act-unphosph-raf /kinetics/chain/kinetics[23]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[23]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[23]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[23]/Ras/GTP-Ras /kinetics/chain/kinetics[23]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/Ras/GTP-Ras /kinetics/chain/kinetics[23]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[23]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[23]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[23]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[23]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[23]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[23]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[23]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[23]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[22]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[23]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[23]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[23]/Ras/GDP-Ras /kinetics/chain/kinetics[23]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/Ras/GDP-Ras /kinetics/chain/kinetics[23]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ras/GTP-Ras /kinetics/chain/kinetics[23]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/GDP-Ras /kinetics/chain/kinetics[23]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ras/GAP* /kinetics/chain/kinetics[23]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/GAP /kinetics/chain/kinetics[23]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[23]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[23]/Ras/dephosph-GAP /kinetics/chain/kinetics[23]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/GAP*/diff /kinetics/chain/kinetics[23]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/GAP*/diff /kinetics/chain/kinetics[23]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[23]/Ras/GAP* /kinetics/chain/kinetics[23]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/Ras/GAP* /kinetics/chain/kinetics[23]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[23]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[23]/Ras/dephosph-GAP /kinetics/chain/kinetics[23]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[23]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[22]/Ras/GAP/diff /kinetics/chain/kinetics[23]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/GAP/diff /kinetics/chain/kinetics[23]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[23]/Ras/GTP-Ras /kinetics/chain/kinetics[23]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/GAP /kinetics/chain/kinetics[23]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[23]/Ras/GAP /kinetics/chain/kinetics[23]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/Ras/GAP /kinetics/chain/kinetics[23]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ras/inact-GEF /kinetics/chain/kinetics[23]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/CaM-GEF /kinetics/chain/kinetics[23]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca4 /kinetics/chain/kinetics[23]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[23]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[23]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[22]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[23]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[23]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[23]/Ras/GDP-Ras /kinetics/chain/kinetics[23]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/CaM-GEF /kinetics/chain/kinetics[23]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[23]/Ras/CaM-GEF /kinetics/chain/kinetics[23]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/Ras/CaM-GEF /kinetics/chain/kinetics[23]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[23]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM/diff /kinetics/chain/kinetics[23]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[23]/CaM/CaM/diff /kinetics/chain/kinetics[23]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[23]/CaM/CaM /kinetics/chain/kinetics[23]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/CaM/CaM /kinetics/chain/kinetics[23]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca3 /kinetics/chain/kinetics[23]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca4 /kinetics/chain/kinetics[23]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ca /kinetics/chain/kinetics[23]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[23]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[23]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[23]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[23]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca3 /kinetics/chain/kinetics[23]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca3 /kinetics/chain/kinetics[23]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[23]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[23]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[23]/PKM/trigger_PKM /kinetics/chain/kinetics[23]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[23]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[23]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca4 /kinetics/chain/kinetics[23]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca4 /kinetics/chain/kinetics[23]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/CaM/CaM /kinetics/chain/kinetics[23]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca /kinetics/chain/kinetics[23]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ca /kinetics/chain/kinetics[23]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[23]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[23]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[23]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[23]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca2 /kinetics/chain/kinetics[23]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca2 /kinetics/chain/kinetics[23]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca3 /kinetics/chain/kinetics[23]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca2 /kinetics/chain/kinetics[23]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ca /kinetics/chain/kinetics[23]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca2 /kinetics/chain/kinetics[23]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca /kinetics/chain/kinetics[23]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ca /kinetics/chain/kinetics[23]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[23]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[23]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[23]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[23]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca /kinetics/chain/kinetics[23]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca /kinetics/chain/kinetics[23]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[23]/Ca REAC A B addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[23]/Ca REAC A B addmsg /kinetics/chain/kinetics[23]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[23]/Ca REAC A B addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[23]/Ca REAC A B addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[23]/Ca REAC A B addmsg /kinetics/chain/kinetics[23]/Ca_diff /kinetics/chain/kinetics[23]/Ca REAC B A addmsg /kinetics/chain/kinetics[22]/Ca/diff /kinetics/chain/kinetics[23]/Ca REAC B A addmsg /kinetics/chain/kinetics[23]/Ca/diff /kinetics/chain/kinetics[23]/Ca REAC A B addmsg /kinetics/chain/kinetics[23]/Ca /kinetics/chain/kinetics[23]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/Ca /kinetics/chain/kinetics[23]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1 /kinetics/chain/kinetics[23]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[23]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ras/GTP-Ras /kinetics/chain/kinetics[23]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKM/trigger_PKM /kinetics/chain/kinetics[23]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[22]/PKM/Ca_detector/diff /kinetics/chain/kinetics[23]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[23]/PKM/Ca_detector/diff /kinetics/chain/kinetics[23]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[23]/PKM/Ca_detector /kinetics/chain/kinetics[23]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PKM/Ca_detector /kinetics/chain/kinetics[23]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[23]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[23]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[23]/PKM/turn_off_activator /kinetics/chain/kinetics[23]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[22]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[23]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[23]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[23]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[23]/PKM/PKM_synthesis /kinetics/chain/kinetics[23]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[23]/PKM/AA_pool /kinetics/chain/kinetics[23]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKM/PKM_synthesis /kinetics/chain/kinetics[23]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PKM/PKM_synthesis /kinetics/chain/kinetics[23]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[23]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[23]/PKC/PKM-zeta /kinetics/chain/kinetics[23]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKM/degraded_PKM /kinetics/chain/kinetics[23]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKM/PKM_degradation /kinetics/chain/kinetics[23]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[23]/PKM/trigger_PKM /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[22]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[23]/PKM/PKM_activator /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PKM/Ca.detector_complex /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[23]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[23]/PKM/turn_off_activator /kinetics/chain/kinetics[23]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[22]/PKM/PKM_activator/diff /kinetics/chain/kinetics[23]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[23]/PKM/PKM_activator/diff /kinetics/chain/kinetics[23]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[23]/PKM/PKM_activator /kinetics/chain/kinetics[23]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PKM/PKM_activator /kinetics/chain/kinetics[23]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKM/PKM_synthesis /kinetics/chain/kinetics[23]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKM/PKM_activator /kinetics/chain/kinetics[23]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca4 /kinetics/chain/kinetics[23]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKM/Ca_detector /kinetics/chain/kinetics[23]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex /kinetics/chain/kinetics[23]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ca_diff /kinetics/chain/kinetics[23]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[23]/Ca /kinetics/chain/kinetics[23]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ca_input /kinetics/chain/kinetics[23]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[24]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[24]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[24]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[24]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[24]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[24]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[24]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[24]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[24]/PKC/PKC-Ca /kinetics/chain/kinetics[24]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PKC/PKC-Ca /kinetics/chain/kinetics[24]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/PKC/PKC-Ca /kinetics/chain/kinetics[24]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[24]/PKC/PKC-cytosolic /kinetics/chain/kinetics[24]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/Ca /kinetics/chain/kinetics[24]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PKC/PKC-Ca /kinetics/chain/kinetics[24]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[24]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[24]/DAG /kinetics/chain/kinetics[24]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PKC/PKC-Ca /kinetics/chain/kinetics[24]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[24]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[24]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[24]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[24]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[24]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[24]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[24]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[24]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[24]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[24]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[24]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[24]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[24]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[24]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[24]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[24]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[24]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[24]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[24]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[24]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[24]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[24]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[24]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[24]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[24]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[24]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[24]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[24]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/PKC/PKC-DAG /kinetics/chain/kinetics[24]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[24]/PKC/PKC-cytosolic /kinetics/chain/kinetics[24]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/DAG /kinetics/chain/kinetics[24]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PKC/PKC-n-DAG /kinetics/chain/kinetics[24]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[24]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[24]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[24]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[24]/PKC/PKC-DAG /kinetics/chain/kinetics[24]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PKC/PKC-DAG /kinetics/chain/kinetics[24]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[24]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[24]/PKC/PKC-n-DAG /kinetics/chain/kinetics[24]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[24]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[24]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[24]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[24]/PKC/PKC-cytosolic /kinetics/chain/kinetics[24]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PKC/PKC-cytosolic /kinetics/chain/kinetics[24]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[24]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[24]/PKM/PKM_degradation /kinetics/chain/kinetics[24]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[23]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[24]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[24]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[24]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[24]/PKC/PKM-zeta /kinetics/chain/kinetics[24]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PKC/PKM-zeta /kinetics/chain/kinetics[24]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[24]/DAG REAC A B addmsg /kinetics/chain/kinetics[24]/PKC/PKC-n-DAG /kinetics/chain/kinetics[24]/DAG REAC A B addmsg /kinetics/chain/kinetics[24]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[24]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[24]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[24]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[24]/PKC/PKM-zeta /kinetics/chain/kinetics[24]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[24]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[24]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[24]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[24]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[24]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[24]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[24]/PKC-active /kinetics/chain/kinetics[24]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[24]/MAPK/craf-1 /kinetics/chain/kinetics[24]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PKC-active /kinetics/chain/kinetics[24]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[24]/Ras/GAP /kinetics/chain/kinetics[24]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PKC-active /kinetics/chain/kinetics[24]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[24]/Ras/inact-GEF /kinetics/chain/kinetics[24]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[24]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[24]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[24]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[24]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[24]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[23]/MAPK*/diff /kinetics/chain/kinetics[24]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[24]/MAPK*/diff /kinetics/chain/kinetics[24]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[24]/MAPK* /kinetics/chain/kinetics[24]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[24]/MAPK/craf-1* /kinetics/chain/kinetics[24]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/MAPK* /kinetics/chain/kinetics[24]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/MAPK* /kinetics/chain/kinetics[24]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[24]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[24]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[24]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[24]/Ras-act-unphosph-raf /kinetics/chain/kinetics[24]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1/diff /kinetics/chain/kinetics[24]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[24]/MAPK/craf-1/diff /kinetics/chain/kinetics[24]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[24]/MAPK/craf-1 /kinetics/chain/kinetics[24]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/MAPK/craf-1 /kinetics/chain/kinetics[24]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[24]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[24]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[24]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[24]/Ras-act-craf /kinetics/chain/kinetics[24]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[24]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[24]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[24]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[24]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1*/diff /kinetics/chain/kinetics[24]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[24]/MAPK/craf-1*/diff /kinetics/chain/kinetics[24]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[24]/MAPK/craf-1* /kinetics/chain/kinetics[24]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/MAPK/craf-1* /kinetics/chain/kinetics[24]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[24]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[24]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[24]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[24]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[24]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK/diff /kinetics/chain/kinetics[24]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[24]/MAPK/MAPKK/diff /kinetics/chain/kinetics[24]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[24]/MAPK/MAPKK /kinetics/chain/kinetics[24]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/MAPK/MAPKK /kinetics/chain/kinetics[24]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[24]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[24]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[24]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[23]/MAPK/MAPK/diff /kinetics/chain/kinetics[24]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[24]/MAPK/MAPK/diff /kinetics/chain/kinetics[24]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[24]/MAPK/MAPK /kinetics/chain/kinetics[24]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/MAPK/MAPK /kinetics/chain/kinetics[24]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[24]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[24]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[24]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1**/diff /kinetics/chain/kinetics[24]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[24]/MAPK/craf-1**/diff /kinetics/chain/kinetics[24]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[24]/MAPK/craf-1** /kinetics/chain/kinetics[24]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/MAPK/craf-1** /kinetics/chain/kinetics[24]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[24]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[24]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[24]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[24]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[24]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[24]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[24]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[24]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[24]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[24]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[24]/MAPK/MAPK-tyr /kinetics/chain/kinetics[24]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/MAPK/MAPK-tyr /kinetics/chain/kinetics[24]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[24]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[24]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[24]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[24]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[24]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[24]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[24]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[24]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[24]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[24]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[24]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[24]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[24]/MAPK/MAPK /kinetics/chain/kinetics[24]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/MAPK/MAPKK* /kinetics/chain/kinetics[24]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[24]/MAPK/MAPK-tyr /kinetics/chain/kinetics[24]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/MAPK/MAPKK* /kinetics/chain/kinetics[24]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[24]/MAPK/MAPKK* /kinetics/chain/kinetics[24]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/MAPK/MAPKK* /kinetics/chain/kinetics[24]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[24]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[24]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[24]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[24]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[24]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[24]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[24]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[24]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[24]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[24]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[24]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[24]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[24]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[24]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[24]/MAPK/MAPKK-ser /kinetics/chain/kinetics[24]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/MAPK/MAPKK-ser /kinetics/chain/kinetics[24]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[24]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[24]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[24]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[24]/Ras-act-unphosph-raf /kinetics/chain/kinetics[24]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[24]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[24]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[24]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[24]/MAPK/MAPKK /kinetics/chain/kinetics[24]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[24]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[24]/MAPK/MAPKK-ser /kinetics/chain/kinetics[24]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[24]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[24]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[24]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[24]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[24]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[24]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[24]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[24]/Ras-act-craf /kinetics/chain/kinetics[24]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[24]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[24]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[24]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[24]/MAPK/MAPKK /kinetics/chain/kinetics[24]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[24]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[24]/MAPK/MAPKK-ser /kinetics/chain/kinetics[24]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[24]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[24]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[24]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[24]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[24]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[24]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[24]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[23]/MKP-1/diff /kinetics/chain/kinetics[24]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[24]/MKP-1/diff /kinetics/chain/kinetics[24]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[24]/MAPK/MAPK-tyr /kinetics/chain/kinetics[24]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/MKP-1 /kinetics/chain/kinetics[24]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[24]/MAPK* /kinetics/chain/kinetics[24]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/MKP-1 /kinetics/chain/kinetics[24]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[24]/MKP-1 /kinetics/chain/kinetics[24]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/MKP-1 /kinetics/chain/kinetics[24]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/MAPK/craf-1* /kinetics/chain/kinetics[24]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[24]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[24]/Ras/GTP-Ras /kinetics/chain/kinetics[24]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[24]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[24]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[24]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[24]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[24]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[24]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[24]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/diff /kinetics/chain/kinetics[24]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[24]/PPhosphatase2A/diff /kinetics/chain/kinetics[24]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[24]/MAPK/craf-1* /kinetics/chain/kinetics[24]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PPhosphatase2A /kinetics/chain/kinetics[24]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[24]/MAPK/MAPKK* /kinetics/chain/kinetics[24]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PPhosphatase2A /kinetics/chain/kinetics[24]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[24]/MAPK/MAPKK-ser /kinetics/chain/kinetics[24]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PPhosphatase2A /kinetics/chain/kinetics[24]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[24]/MAPK/craf-1** /kinetics/chain/kinetics[24]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PPhosphatase2A /kinetics/chain/kinetics[24]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[24]/PPhosphatase2A /kinetics/chain/kinetics[24]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PPhosphatase2A /kinetics/chain/kinetics[24]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/Ras/inact-GEF /kinetics/chain/kinetics[24]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[24]/Ras/GEF* /kinetics/chain/kinetics[24]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[24]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[24]/Ras/dephosph-GEF /kinetics/chain/kinetics[24]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[24]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[24]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[24]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[24]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[23]/Ras/inact-GEF/diff /kinetics/chain/kinetics[24]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[24]/Ras/inact-GEF/diff /kinetics/chain/kinetics[24]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[24]/Ras/inact-GEF /kinetics/chain/kinetics[24]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[24]/Ras/GDP-Ras /kinetics/chain/kinetics[24]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/Ras/inact-GEF /kinetics/chain/kinetics[24]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/Ras/inact-GEF /kinetics/chain/kinetics[24]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[24]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[24]/Ras/dephosph-GEF /kinetics/chain/kinetics[24]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[24]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[24]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[23]/Ras/GEF*/diff /kinetics/chain/kinetics[24]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[24]/Ras/GEF*/diff /kinetics/chain/kinetics[24]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[24]/Ras/GEF* /kinetics/chain/kinetics[24]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[24]/Ras/GDP-Ras /kinetics/chain/kinetics[24]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/Ras/GEF* /kinetics/chain/kinetics[24]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/Ras/GEF* /kinetics/chain/kinetics[24]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/Ras-act-craf /kinetics/chain/kinetics[24]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[24]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[24]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[24]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[24]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[24]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[24]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[24]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[24]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[24]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[24]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[24]/Ras-act-unphosph-raf /kinetics/chain/kinetics[24]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[23]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[24]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[24]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[24]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[24]/Ras/GTP-Ras /kinetics/chain/kinetics[24]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/Ras/GTP-Ras /kinetics/chain/kinetics[24]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[24]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[24]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[24]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[24]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[24]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[24]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[24]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[24]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[24]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[23]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[24]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[24]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[24]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[24]/Ras/GDP-Ras /kinetics/chain/kinetics[24]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/Ras/GDP-Ras /kinetics/chain/kinetics[24]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/Ras/GTP-Ras /kinetics/chain/kinetics[24]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/Ras/GDP-Ras /kinetics/chain/kinetics[24]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[24]/Ras/GAP* /kinetics/chain/kinetics[24]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/Ras/GAP /kinetics/chain/kinetics[24]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[24]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[24]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[24]/Ras/dephosph-GAP /kinetics/chain/kinetics[24]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[23]/Ras/GAP*/diff /kinetics/chain/kinetics[24]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[24]/Ras/GAP*/diff /kinetics/chain/kinetics[24]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[24]/Ras/GAP* /kinetics/chain/kinetics[24]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/Ras/GAP* /kinetics/chain/kinetics[24]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[24]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[24]/Ras/dephosph-GAP /kinetics/chain/kinetics[24]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[24]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[24]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[23]/Ras/GAP/diff /kinetics/chain/kinetics[24]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[24]/Ras/GAP/diff /kinetics/chain/kinetics[24]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[24]/Ras/GTP-Ras /kinetics/chain/kinetics[24]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/Ras/GAP /kinetics/chain/kinetics[24]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[24]/Ras/GAP /kinetics/chain/kinetics[24]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/Ras/GAP /kinetics/chain/kinetics[24]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/Ras/inact-GEF /kinetics/chain/kinetics[24]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/Ras/CaM-GEF /kinetics/chain/kinetics[24]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca4 /kinetics/chain/kinetics[24]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[24]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[24]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[24]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[23]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[24]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[24]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[24]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[24]/Ras/GDP-Ras /kinetics/chain/kinetics[24]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/Ras/CaM-GEF /kinetics/chain/kinetics[24]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[24]/Ras/CaM-GEF /kinetics/chain/kinetics[24]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/Ras/CaM-GEF /kinetics/chain/kinetics[24]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[24]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[23]/CaM/CaM/diff /kinetics/chain/kinetics[24]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[24]/CaM/CaM/diff /kinetics/chain/kinetics[24]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[24]/CaM/CaM /kinetics/chain/kinetics[24]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/CaM/CaM /kinetics/chain/kinetics[24]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca3 /kinetics/chain/kinetics[24]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca4 /kinetics/chain/kinetics[24]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[24]/Ca /kinetics/chain/kinetics[24]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[24]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[24]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[24]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[24]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca3 /kinetics/chain/kinetics[24]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca3 /kinetics/chain/kinetics[24]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[24]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[24]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[24]/PKM/trigger_PKM /kinetics/chain/kinetics[24]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[24]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[24]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca4 /kinetics/chain/kinetics[24]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca4 /kinetics/chain/kinetics[24]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/CaM/CaM /kinetics/chain/kinetics[24]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca /kinetics/chain/kinetics[24]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[24]/Ca /kinetics/chain/kinetics[24]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[24]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[24]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[24]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[24]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca2 /kinetics/chain/kinetics[24]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca2 /kinetics/chain/kinetics[24]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca3 /kinetics/chain/kinetics[24]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca2 /kinetics/chain/kinetics[24]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/Ca /kinetics/chain/kinetics[24]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca2 /kinetics/chain/kinetics[24]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca /kinetics/chain/kinetics[24]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/Ca /kinetics/chain/kinetics[24]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[24]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[24]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[24]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[24]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca /kinetics/chain/kinetics[24]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca /kinetics/chain/kinetics[24]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[24]/Ca REAC A B addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[24]/Ca REAC A B addmsg /kinetics/chain/kinetics[24]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[24]/Ca REAC A B addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[24]/Ca REAC A B addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[24]/Ca REAC A B addmsg /kinetics/chain/kinetics[24]/Ca_diff /kinetics/chain/kinetics[24]/Ca REAC B A addmsg /kinetics/chain/kinetics[23]/Ca/diff /kinetics/chain/kinetics[24]/Ca REAC B A addmsg /kinetics/chain/kinetics[24]/Ca/diff /kinetics/chain/kinetics[24]/Ca REAC A B addmsg /kinetics/chain/kinetics[24]/Ca /kinetics/chain/kinetics[24]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/Ca /kinetics/chain/kinetics[24]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/MAPK/craf-1 /kinetics/chain/kinetics[24]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[24]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[24]/Ras/GTP-Ras /kinetics/chain/kinetics[24]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PKM/trigger_PKM /kinetics/chain/kinetics[24]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[23]/PKM/Ca_detector/diff /kinetics/chain/kinetics[24]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[24]/PKM/Ca_detector/diff /kinetics/chain/kinetics[24]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[24]/PKM/Ca_detector /kinetics/chain/kinetics[24]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PKM/Ca_detector /kinetics/chain/kinetics[24]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[24]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[24]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[24]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[24]/PKM/turn_off_activator /kinetics/chain/kinetics[24]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[23]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[24]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[24]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[24]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[24]/PKM/PKM_synthesis /kinetics/chain/kinetics[24]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[24]/PKM/AA_pool /kinetics/chain/kinetics[24]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PKM/PKM_synthesis /kinetics/chain/kinetics[24]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PKM/PKM_synthesis /kinetics/chain/kinetics[24]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[24]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[24]/PKC/PKM-zeta /kinetics/chain/kinetics[24]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PKM/degraded_PKM /kinetics/chain/kinetics[24]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[24]/PKM/PKM_degradation /kinetics/chain/kinetics[24]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[24]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[24]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[24]/PKM/trigger_PKM /kinetics/chain/kinetics[24]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[23]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[24]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[24]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[24]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[24]/PKM/Ca.detector_complex /kinetics/chain/kinetics[24]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[24]/PKM/PKM_activator /kinetics/chain/kinetics[24]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PKM/Ca.detector_complex /kinetics/chain/kinetics[24]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PKM/Ca.detector_complex /kinetics/chain/kinetics[24]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[24]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[24]/PKM/turn_off_activator /kinetics/chain/kinetics[24]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[23]/PKM/PKM_activator/diff /kinetics/chain/kinetics[24]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[24]/PKM/PKM_activator/diff /kinetics/chain/kinetics[24]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[24]/PKM/PKM_activator /kinetics/chain/kinetics[24]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PKM/PKM_activator /kinetics/chain/kinetics[24]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/PKM/PKM_synthesis /kinetics/chain/kinetics[24]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PKM/PKM_activator /kinetics/chain/kinetics[24]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca4 /kinetics/chain/kinetics[24]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PKM/Ca_detector /kinetics/chain/kinetics[24]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[24]/PKM/Ca.detector_complex /kinetics/chain/kinetics[24]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[24]/Ca_diff /kinetics/chain/kinetics[24]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[24]/Ca /kinetics/chain/kinetics[24]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[24]/Ca_input /kinetics/chain/kinetics[24]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[25]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[25]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[25]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[25]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[25]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[24]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[25]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[25]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[25]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[25]/PKC/PKC-Ca /kinetics/chain/kinetics[25]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PKC/PKC-Ca /kinetics/chain/kinetics[25]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/PKC/PKC-Ca /kinetics/chain/kinetics[25]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[25]/PKC/PKC-cytosolic /kinetics/chain/kinetics[25]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/Ca /kinetics/chain/kinetics[25]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PKC/PKC-Ca /kinetics/chain/kinetics[25]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[25]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[25]/DAG /kinetics/chain/kinetics[25]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PKC/PKC-Ca /kinetics/chain/kinetics[25]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[25]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[25]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[25]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[25]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[25]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[25]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[24]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[25]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[25]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[25]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[25]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[25]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[25]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[25]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[24]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[25]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[25]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[25]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[25]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[25]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[25]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[25]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[25]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[25]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[24]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[25]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[25]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[25]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[25]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[25]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[25]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/PKC/PKC-DAG /kinetics/chain/kinetics[25]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[25]/PKC/PKC-cytosolic /kinetics/chain/kinetics[25]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/DAG /kinetics/chain/kinetics[25]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PKC/PKC-n-DAG /kinetics/chain/kinetics[25]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[24]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[25]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[25]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[25]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[25]/PKC/PKC-DAG /kinetics/chain/kinetics[25]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PKC/PKC-DAG /kinetics/chain/kinetics[25]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[25]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[25]/PKC/PKC-n-DAG /kinetics/chain/kinetics[25]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[24]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[25]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[25]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[25]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[25]/PKC/PKC-cytosolic /kinetics/chain/kinetics[25]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PKC/PKC-cytosolic /kinetics/chain/kinetics[25]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[25]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[25]/PKM/PKM_degradation /kinetics/chain/kinetics[25]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[24]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[25]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[25]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[25]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[25]/PKC/PKM-zeta /kinetics/chain/kinetics[25]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PKC/PKM-zeta /kinetics/chain/kinetics[25]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[25]/DAG REAC A B addmsg /kinetics/chain/kinetics[25]/PKC/PKC-n-DAG /kinetics/chain/kinetics[25]/DAG REAC A B addmsg /kinetics/chain/kinetics[25]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[25]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[25]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[25]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[25]/PKC/PKM-zeta /kinetics/chain/kinetics[25]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[25]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[25]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[25]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[25]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[25]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[25]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[25]/PKC-active /kinetics/chain/kinetics[25]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[25]/MAPK/craf-1 /kinetics/chain/kinetics[25]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PKC-active /kinetics/chain/kinetics[25]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[25]/Ras/GAP /kinetics/chain/kinetics[25]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PKC-active /kinetics/chain/kinetics[25]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[25]/Ras/inact-GEF /kinetics/chain/kinetics[25]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[25]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[25]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[25]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[25]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[25]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[24]/MAPK*/diff /kinetics/chain/kinetics[25]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[25]/MAPK*/diff /kinetics/chain/kinetics[25]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[25]/MAPK* /kinetics/chain/kinetics[25]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[25]/MAPK/craf-1* /kinetics/chain/kinetics[25]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/MAPK* /kinetics/chain/kinetics[25]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/MAPK* /kinetics/chain/kinetics[25]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[25]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[25]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[25]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[25]/Ras-act-unphosph-raf /kinetics/chain/kinetics[25]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[24]/MAPK/craf-1/diff /kinetics/chain/kinetics[25]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[25]/MAPK/craf-1/diff /kinetics/chain/kinetics[25]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[25]/MAPK/craf-1 /kinetics/chain/kinetics[25]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/MAPK/craf-1 /kinetics/chain/kinetics[25]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[25]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[25]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[25]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[25]/Ras-act-craf /kinetics/chain/kinetics[25]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[25]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[25]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[25]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[25]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[24]/MAPK/craf-1*/diff /kinetics/chain/kinetics[25]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[25]/MAPK/craf-1*/diff /kinetics/chain/kinetics[25]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[25]/MAPK/craf-1* /kinetics/chain/kinetics[25]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/MAPK/craf-1* /kinetics/chain/kinetics[25]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[25]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[25]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[25]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[25]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[25]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[24]/MAPK/MAPKK/diff /kinetics/chain/kinetics[25]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[25]/MAPK/MAPKK/diff /kinetics/chain/kinetics[25]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[25]/MAPK/MAPKK /kinetics/chain/kinetics[25]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/MAPK/MAPKK /kinetics/chain/kinetics[25]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[25]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[25]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[25]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[24]/MAPK/MAPK/diff /kinetics/chain/kinetics[25]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[25]/MAPK/MAPK/diff /kinetics/chain/kinetics[25]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[25]/MAPK/MAPK /kinetics/chain/kinetics[25]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/MAPK/MAPK /kinetics/chain/kinetics[25]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[25]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[25]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[25]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[24]/MAPK/craf-1**/diff /kinetics/chain/kinetics[25]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[25]/MAPK/craf-1**/diff /kinetics/chain/kinetics[25]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[25]/MAPK/craf-1** /kinetics/chain/kinetics[25]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/MAPK/craf-1** /kinetics/chain/kinetics[25]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[25]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[25]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[25]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[25]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[25]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[25]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[25]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[24]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[25]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[25]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[25]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[25]/MAPK/MAPK-tyr /kinetics/chain/kinetics[25]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/MAPK/MAPK-tyr /kinetics/chain/kinetics[25]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[25]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[25]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[25]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[25]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[25]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[25]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[25]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[25]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[25]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[24]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[25]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[25]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[25]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[25]/MAPK/MAPK /kinetics/chain/kinetics[25]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/MAPK/MAPKK* /kinetics/chain/kinetics[25]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[25]/MAPK/MAPK-tyr /kinetics/chain/kinetics[25]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/MAPK/MAPKK* /kinetics/chain/kinetics[25]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[25]/MAPK/MAPKK* /kinetics/chain/kinetics[25]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/MAPK/MAPKK* /kinetics/chain/kinetics[25]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[25]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[25]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[25]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[25]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[25]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[25]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[25]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[25]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[25]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[25]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[25]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[24]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[25]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[25]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[25]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[25]/MAPK/MAPKK-ser /kinetics/chain/kinetics[25]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/MAPK/MAPKK-ser /kinetics/chain/kinetics[25]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[25]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[25]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[25]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[25]/Ras-act-unphosph-raf /kinetics/chain/kinetics[25]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[24]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[25]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[25]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[25]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[25]/MAPK/MAPKK /kinetics/chain/kinetics[25]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[25]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[25]/MAPK/MAPKK-ser /kinetics/chain/kinetics[25]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[25]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[25]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[25]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[25]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[25]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[25]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[25]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[25]/Ras-act-craf /kinetics/chain/kinetics[25]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[24]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[25]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[25]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[25]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[25]/MAPK/MAPKK /kinetics/chain/kinetics[25]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[25]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[25]/MAPK/MAPKK-ser /kinetics/chain/kinetics[25]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[25]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[25]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[25]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[25]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[25]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[25]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[25]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[24]/MKP-1/diff /kinetics/chain/kinetics[25]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[25]/MKP-1/diff /kinetics/chain/kinetics[25]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[25]/MAPK/MAPK-tyr /kinetics/chain/kinetics[25]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/MKP-1 /kinetics/chain/kinetics[25]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[25]/MAPK* /kinetics/chain/kinetics[25]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/MKP-1 /kinetics/chain/kinetics[25]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[25]/MKP-1 /kinetics/chain/kinetics[25]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/MKP-1 /kinetics/chain/kinetics[25]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/MAPK/craf-1* /kinetics/chain/kinetics[25]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[25]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[25]/Ras/GTP-Ras /kinetics/chain/kinetics[25]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[25]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[25]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[25]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[25]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[25]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[25]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[25]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[24]/PPhosphatase2A/diff /kinetics/chain/kinetics[25]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[25]/PPhosphatase2A/diff /kinetics/chain/kinetics[25]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[25]/MAPK/craf-1* /kinetics/chain/kinetics[25]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PPhosphatase2A /kinetics/chain/kinetics[25]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[25]/MAPK/MAPKK* /kinetics/chain/kinetics[25]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PPhosphatase2A /kinetics/chain/kinetics[25]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[25]/MAPK/MAPKK-ser /kinetics/chain/kinetics[25]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PPhosphatase2A /kinetics/chain/kinetics[25]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[25]/MAPK/craf-1** /kinetics/chain/kinetics[25]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PPhosphatase2A /kinetics/chain/kinetics[25]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[25]/PPhosphatase2A /kinetics/chain/kinetics[25]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PPhosphatase2A /kinetics/chain/kinetics[25]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/Ras/inact-GEF /kinetics/chain/kinetics[25]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[25]/Ras/GEF* /kinetics/chain/kinetics[25]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[25]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[25]/Ras/dephosph-GEF /kinetics/chain/kinetics[25]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[25]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[25]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[25]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[25]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[24]/Ras/inact-GEF/diff /kinetics/chain/kinetics[25]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[25]/Ras/inact-GEF/diff /kinetics/chain/kinetics[25]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[25]/Ras/inact-GEF /kinetics/chain/kinetics[25]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[25]/Ras/GDP-Ras /kinetics/chain/kinetics[25]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/Ras/inact-GEF /kinetics/chain/kinetics[25]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/Ras/inact-GEF /kinetics/chain/kinetics[25]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[25]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[25]/Ras/dephosph-GEF /kinetics/chain/kinetics[25]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[25]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[25]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[24]/Ras/GEF*/diff /kinetics/chain/kinetics[25]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[25]/Ras/GEF*/diff /kinetics/chain/kinetics[25]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[25]/Ras/GEF* /kinetics/chain/kinetics[25]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[25]/Ras/GDP-Ras /kinetics/chain/kinetics[25]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/Ras/GEF* /kinetics/chain/kinetics[25]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/Ras/GEF* /kinetics/chain/kinetics[25]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/Ras-act-craf /kinetics/chain/kinetics[25]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[25]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[25]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[25]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[25]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[25]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[25]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[25]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[25]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[25]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[25]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[25]/Ras-act-unphosph-raf /kinetics/chain/kinetics[25]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[24]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[25]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[25]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[25]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[25]/Ras/GTP-Ras /kinetics/chain/kinetics[25]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/Ras/GTP-Ras /kinetics/chain/kinetics[25]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[25]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[25]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[25]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[25]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[25]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[25]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[25]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[25]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[25]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[24]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[25]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[25]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[25]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[25]/Ras/GDP-Ras /kinetics/chain/kinetics[25]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/Ras/GDP-Ras /kinetics/chain/kinetics[25]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/Ras/GTP-Ras /kinetics/chain/kinetics[25]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/Ras/GDP-Ras /kinetics/chain/kinetics[25]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[25]/Ras/GAP* /kinetics/chain/kinetics[25]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/Ras/GAP /kinetics/chain/kinetics[25]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[25]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[25]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[25]/Ras/dephosph-GAP /kinetics/chain/kinetics[25]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[24]/Ras/GAP*/diff /kinetics/chain/kinetics[25]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[25]/Ras/GAP*/diff /kinetics/chain/kinetics[25]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[25]/Ras/GAP* /kinetics/chain/kinetics[25]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/Ras/GAP* /kinetics/chain/kinetics[25]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[25]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[25]/Ras/dephosph-GAP /kinetics/chain/kinetics[25]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[25]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[25]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[24]/Ras/GAP/diff /kinetics/chain/kinetics[25]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[25]/Ras/GAP/diff /kinetics/chain/kinetics[25]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[25]/Ras/GTP-Ras /kinetics/chain/kinetics[25]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/Ras/GAP /kinetics/chain/kinetics[25]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[25]/Ras/GAP /kinetics/chain/kinetics[25]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/Ras/GAP /kinetics/chain/kinetics[25]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/Ras/inact-GEF /kinetics/chain/kinetics[25]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/Ras/CaM-GEF /kinetics/chain/kinetics[25]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca4 /kinetics/chain/kinetics[25]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[25]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[25]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[25]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[24]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[25]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[25]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[25]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[25]/Ras/GDP-Ras /kinetics/chain/kinetics[25]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/Ras/CaM-GEF /kinetics/chain/kinetics[25]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[25]/Ras/CaM-GEF /kinetics/chain/kinetics[25]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/Ras/CaM-GEF /kinetics/chain/kinetics[25]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[25]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[24]/CaM/CaM/diff /kinetics/chain/kinetics[25]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[25]/CaM/CaM/diff /kinetics/chain/kinetics[25]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[25]/CaM/CaM /kinetics/chain/kinetics[25]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/CaM/CaM /kinetics/chain/kinetics[25]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca3 /kinetics/chain/kinetics[25]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca4 /kinetics/chain/kinetics[25]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[25]/Ca /kinetics/chain/kinetics[25]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[25]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[25]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[25]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[25]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca3 /kinetics/chain/kinetics[25]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca3 /kinetics/chain/kinetics[25]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[25]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[25]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[25]/PKM/trigger_PKM /kinetics/chain/kinetics[25]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[25]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[25]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca4 /kinetics/chain/kinetics[25]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca4 /kinetics/chain/kinetics[25]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/CaM/CaM /kinetics/chain/kinetics[25]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca /kinetics/chain/kinetics[25]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[25]/Ca /kinetics/chain/kinetics[25]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[25]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[25]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[25]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[25]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca2 /kinetics/chain/kinetics[25]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca2 /kinetics/chain/kinetics[25]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca3 /kinetics/chain/kinetics[25]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca2 /kinetics/chain/kinetics[25]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/Ca /kinetics/chain/kinetics[25]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca2 /kinetics/chain/kinetics[25]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca /kinetics/chain/kinetics[25]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/Ca /kinetics/chain/kinetics[25]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[25]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[25]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[24]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[25]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[25]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca /kinetics/chain/kinetics[25]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca /kinetics/chain/kinetics[25]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[25]/Ca REAC A B addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[25]/Ca REAC A B addmsg /kinetics/chain/kinetics[25]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[25]/Ca REAC A B addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[25]/Ca REAC A B addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[25]/Ca REAC A B addmsg /kinetics/chain/kinetics[25]/Ca_diff /kinetics/chain/kinetics[25]/Ca REAC B A addmsg /kinetics/chain/kinetics[24]/Ca/diff /kinetics/chain/kinetics[25]/Ca REAC B A addmsg /kinetics/chain/kinetics[25]/Ca/diff /kinetics/chain/kinetics[25]/Ca REAC A B addmsg /kinetics/chain/kinetics[25]/Ca /kinetics/chain/kinetics[25]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/Ca /kinetics/chain/kinetics[25]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/MAPK/craf-1 /kinetics/chain/kinetics[25]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[25]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[25]/Ras/GTP-Ras /kinetics/chain/kinetics[25]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PKM/trigger_PKM /kinetics/chain/kinetics[25]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[24]/PKM/Ca_detector/diff /kinetics/chain/kinetics[25]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[25]/PKM/Ca_detector/diff /kinetics/chain/kinetics[25]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[25]/PKM/Ca_detector /kinetics/chain/kinetics[25]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PKM/Ca_detector /kinetics/chain/kinetics[25]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[25]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[25]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[25]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[25]/PKM/turn_off_activator /kinetics/chain/kinetics[25]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[24]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[25]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[25]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[25]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[25]/PKM/PKM_synthesis /kinetics/chain/kinetics[25]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[25]/PKM/AA_pool /kinetics/chain/kinetics[25]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PKM/PKM_synthesis /kinetics/chain/kinetics[25]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PKM/PKM_synthesis /kinetics/chain/kinetics[25]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[25]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[25]/PKC/PKM-zeta /kinetics/chain/kinetics[25]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PKM/degraded_PKM /kinetics/chain/kinetics[25]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[25]/PKM/PKM_degradation /kinetics/chain/kinetics[25]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[25]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[25]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[25]/PKM/trigger_PKM /kinetics/chain/kinetics[25]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[24]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[25]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[25]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[25]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[25]/PKM/Ca.detector_complex /kinetics/chain/kinetics[25]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[25]/PKM/PKM_activator /kinetics/chain/kinetics[25]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PKM/Ca.detector_complex /kinetics/chain/kinetics[25]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PKM/Ca.detector_complex /kinetics/chain/kinetics[25]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[25]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[25]/PKM/turn_off_activator /kinetics/chain/kinetics[25]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[24]/PKM/PKM_activator/diff /kinetics/chain/kinetics[25]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[25]/PKM/PKM_activator/diff /kinetics/chain/kinetics[25]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[25]/PKM/PKM_activator /kinetics/chain/kinetics[25]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PKM/PKM_activator /kinetics/chain/kinetics[25]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/PKM/PKM_synthesis /kinetics/chain/kinetics[25]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PKM/PKM_activator /kinetics/chain/kinetics[25]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca4 /kinetics/chain/kinetics[25]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PKM/Ca_detector /kinetics/chain/kinetics[25]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[25]/PKM/Ca.detector_complex /kinetics/chain/kinetics[25]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[25]/Ca_diff /kinetics/chain/kinetics[25]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[25]/Ca /kinetics/chain/kinetics[25]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[25]/Ca_input /kinetics/chain/kinetics[25]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[26]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[26]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[26]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[26]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[26]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[25]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[26]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[26]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[26]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[26]/PKC/PKC-Ca /kinetics/chain/kinetics[26]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PKC/PKC-Ca /kinetics/chain/kinetics[26]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/PKC/PKC-Ca /kinetics/chain/kinetics[26]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[26]/PKC/PKC-cytosolic /kinetics/chain/kinetics[26]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/Ca /kinetics/chain/kinetics[26]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PKC/PKC-Ca /kinetics/chain/kinetics[26]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[26]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[26]/DAG /kinetics/chain/kinetics[26]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PKC/PKC-Ca /kinetics/chain/kinetics[26]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[26]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[26]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[26]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[26]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[26]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[26]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[25]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[26]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[26]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[26]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[26]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[26]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[26]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[26]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[25]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[26]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[26]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[26]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[26]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[26]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[26]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[26]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[26]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[26]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[25]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[26]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[26]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[26]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[26]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[26]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[26]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/PKC/PKC-DAG /kinetics/chain/kinetics[26]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[26]/PKC/PKC-cytosolic /kinetics/chain/kinetics[26]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/DAG /kinetics/chain/kinetics[26]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PKC/PKC-n-DAG /kinetics/chain/kinetics[26]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[25]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[26]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[26]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[26]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[26]/PKC/PKC-DAG /kinetics/chain/kinetics[26]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PKC/PKC-DAG /kinetics/chain/kinetics[26]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[26]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[26]/PKC/PKC-n-DAG /kinetics/chain/kinetics[26]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[25]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[26]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[26]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[26]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[26]/PKC/PKC-cytosolic /kinetics/chain/kinetics[26]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PKC/PKC-cytosolic /kinetics/chain/kinetics[26]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[26]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[26]/PKM/PKM_degradation /kinetics/chain/kinetics[26]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[25]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[26]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[26]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[26]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[26]/PKC/PKM-zeta /kinetics/chain/kinetics[26]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PKC/PKM-zeta /kinetics/chain/kinetics[26]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[26]/DAG REAC A B addmsg /kinetics/chain/kinetics[26]/PKC/PKC-n-DAG /kinetics/chain/kinetics[26]/DAG REAC A B addmsg /kinetics/chain/kinetics[26]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[26]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[26]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[26]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[26]/PKC/PKM-zeta /kinetics/chain/kinetics[26]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[26]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[26]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[26]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[26]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[26]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[26]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[26]/PKC-active /kinetics/chain/kinetics[26]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[26]/MAPK/craf-1 /kinetics/chain/kinetics[26]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PKC-active /kinetics/chain/kinetics[26]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[26]/Ras/GAP /kinetics/chain/kinetics[26]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PKC-active /kinetics/chain/kinetics[26]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[26]/Ras/inact-GEF /kinetics/chain/kinetics[26]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[26]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[26]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[26]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[26]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[26]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[25]/MAPK*/diff /kinetics/chain/kinetics[26]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[26]/MAPK*/diff /kinetics/chain/kinetics[26]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[26]/MAPK* /kinetics/chain/kinetics[26]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[26]/MAPK/craf-1* /kinetics/chain/kinetics[26]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/MAPK* /kinetics/chain/kinetics[26]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/MAPK* /kinetics/chain/kinetics[26]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[26]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[26]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[26]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[26]/Ras-act-unphosph-raf /kinetics/chain/kinetics[26]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[25]/MAPK/craf-1/diff /kinetics/chain/kinetics[26]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[26]/MAPK/craf-1/diff /kinetics/chain/kinetics[26]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[26]/MAPK/craf-1 /kinetics/chain/kinetics[26]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/MAPK/craf-1 /kinetics/chain/kinetics[26]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[26]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[26]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[26]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[26]/Ras-act-craf /kinetics/chain/kinetics[26]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[26]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[26]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[26]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[26]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[25]/MAPK/craf-1*/diff /kinetics/chain/kinetics[26]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[26]/MAPK/craf-1*/diff /kinetics/chain/kinetics[26]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[26]/MAPK/craf-1* /kinetics/chain/kinetics[26]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/MAPK/craf-1* /kinetics/chain/kinetics[26]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[26]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[26]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[26]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[26]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[26]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[25]/MAPK/MAPKK/diff /kinetics/chain/kinetics[26]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[26]/MAPK/MAPKK/diff /kinetics/chain/kinetics[26]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[26]/MAPK/MAPKK /kinetics/chain/kinetics[26]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/MAPK/MAPKK /kinetics/chain/kinetics[26]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[26]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[26]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[26]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[25]/MAPK/MAPK/diff /kinetics/chain/kinetics[26]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[26]/MAPK/MAPK/diff /kinetics/chain/kinetics[26]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[26]/MAPK/MAPK /kinetics/chain/kinetics[26]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/MAPK/MAPK /kinetics/chain/kinetics[26]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[26]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[26]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[26]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[25]/MAPK/craf-1**/diff /kinetics/chain/kinetics[26]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[26]/MAPK/craf-1**/diff /kinetics/chain/kinetics[26]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[26]/MAPK/craf-1** /kinetics/chain/kinetics[26]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/MAPK/craf-1** /kinetics/chain/kinetics[26]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[26]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[26]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[26]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[26]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[26]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[26]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[26]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[25]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[26]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[26]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[26]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[26]/MAPK/MAPK-tyr /kinetics/chain/kinetics[26]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/MAPK/MAPK-tyr /kinetics/chain/kinetics[26]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[26]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[26]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[26]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[26]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[26]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[26]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[26]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[26]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[26]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[25]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[26]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[26]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[26]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[26]/MAPK/MAPK /kinetics/chain/kinetics[26]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/MAPK/MAPKK* /kinetics/chain/kinetics[26]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[26]/MAPK/MAPK-tyr /kinetics/chain/kinetics[26]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/MAPK/MAPKK* /kinetics/chain/kinetics[26]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[26]/MAPK/MAPKK* /kinetics/chain/kinetics[26]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/MAPK/MAPKK* /kinetics/chain/kinetics[26]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[26]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[26]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[26]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[26]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[26]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[26]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[26]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[26]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[26]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[26]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[26]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[25]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[26]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[26]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[26]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[26]/MAPK/MAPKK-ser /kinetics/chain/kinetics[26]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/MAPK/MAPKK-ser /kinetics/chain/kinetics[26]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[26]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[26]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[26]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[26]/Ras-act-unphosph-raf /kinetics/chain/kinetics[26]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[25]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[26]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[26]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[26]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[26]/MAPK/MAPKK /kinetics/chain/kinetics[26]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[26]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[26]/MAPK/MAPKK-ser /kinetics/chain/kinetics[26]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[26]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[26]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[26]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[26]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[26]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[26]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[26]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[26]/Ras-act-craf /kinetics/chain/kinetics[26]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[25]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[26]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[26]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[26]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[26]/MAPK/MAPKK /kinetics/chain/kinetics[26]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[26]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[26]/MAPK/MAPKK-ser /kinetics/chain/kinetics[26]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[26]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[26]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[26]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[26]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[26]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[26]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[26]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[25]/MKP-1/diff /kinetics/chain/kinetics[26]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[26]/MKP-1/diff /kinetics/chain/kinetics[26]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[26]/MAPK/MAPK-tyr /kinetics/chain/kinetics[26]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/MKP-1 /kinetics/chain/kinetics[26]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[26]/MAPK* /kinetics/chain/kinetics[26]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/MKP-1 /kinetics/chain/kinetics[26]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[26]/MKP-1 /kinetics/chain/kinetics[26]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/MKP-1 /kinetics/chain/kinetics[26]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/MAPK/craf-1* /kinetics/chain/kinetics[26]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[26]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[26]/Ras/GTP-Ras /kinetics/chain/kinetics[26]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[26]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[26]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[26]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[26]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[26]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[26]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[26]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[25]/PPhosphatase2A/diff /kinetics/chain/kinetics[26]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[26]/PPhosphatase2A/diff /kinetics/chain/kinetics[26]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[26]/MAPK/craf-1* /kinetics/chain/kinetics[26]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PPhosphatase2A /kinetics/chain/kinetics[26]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[26]/MAPK/MAPKK* /kinetics/chain/kinetics[26]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PPhosphatase2A /kinetics/chain/kinetics[26]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[26]/MAPK/MAPKK-ser /kinetics/chain/kinetics[26]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PPhosphatase2A /kinetics/chain/kinetics[26]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[26]/MAPK/craf-1** /kinetics/chain/kinetics[26]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PPhosphatase2A /kinetics/chain/kinetics[26]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[26]/PPhosphatase2A /kinetics/chain/kinetics[26]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PPhosphatase2A /kinetics/chain/kinetics[26]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/Ras/inact-GEF /kinetics/chain/kinetics[26]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[26]/Ras/GEF* /kinetics/chain/kinetics[26]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[26]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[26]/Ras/dephosph-GEF /kinetics/chain/kinetics[26]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[26]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[26]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[26]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[26]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[25]/Ras/inact-GEF/diff /kinetics/chain/kinetics[26]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[26]/Ras/inact-GEF/diff /kinetics/chain/kinetics[26]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[26]/Ras/inact-GEF /kinetics/chain/kinetics[26]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[26]/Ras/GDP-Ras /kinetics/chain/kinetics[26]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/Ras/inact-GEF /kinetics/chain/kinetics[26]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/Ras/inact-GEF /kinetics/chain/kinetics[26]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[26]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[26]/Ras/dephosph-GEF /kinetics/chain/kinetics[26]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[26]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[26]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[25]/Ras/GEF*/diff /kinetics/chain/kinetics[26]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[26]/Ras/GEF*/diff /kinetics/chain/kinetics[26]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[26]/Ras/GEF* /kinetics/chain/kinetics[26]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[26]/Ras/GDP-Ras /kinetics/chain/kinetics[26]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/Ras/GEF* /kinetics/chain/kinetics[26]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/Ras/GEF* /kinetics/chain/kinetics[26]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/Ras-act-craf /kinetics/chain/kinetics[26]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[26]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[26]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[26]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[26]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[26]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[26]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[26]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[26]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[26]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[26]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[26]/Ras-act-unphosph-raf /kinetics/chain/kinetics[26]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[25]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[26]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[26]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[26]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[26]/Ras/GTP-Ras /kinetics/chain/kinetics[26]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/Ras/GTP-Ras /kinetics/chain/kinetics[26]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[26]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[26]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[26]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[26]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[26]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[26]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[26]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[26]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[26]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[25]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[26]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[26]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[26]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[26]/Ras/GDP-Ras /kinetics/chain/kinetics[26]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/Ras/GDP-Ras /kinetics/chain/kinetics[26]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/Ras/GTP-Ras /kinetics/chain/kinetics[26]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/Ras/GDP-Ras /kinetics/chain/kinetics[26]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[26]/Ras/GAP* /kinetics/chain/kinetics[26]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/Ras/GAP /kinetics/chain/kinetics[26]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[26]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[26]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[26]/Ras/dephosph-GAP /kinetics/chain/kinetics[26]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[25]/Ras/GAP*/diff /kinetics/chain/kinetics[26]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[26]/Ras/GAP*/diff /kinetics/chain/kinetics[26]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[26]/Ras/GAP* /kinetics/chain/kinetics[26]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/Ras/GAP* /kinetics/chain/kinetics[26]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[26]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[26]/Ras/dephosph-GAP /kinetics/chain/kinetics[26]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[26]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[26]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[25]/Ras/GAP/diff /kinetics/chain/kinetics[26]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[26]/Ras/GAP/diff /kinetics/chain/kinetics[26]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[26]/Ras/GTP-Ras /kinetics/chain/kinetics[26]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/Ras/GAP /kinetics/chain/kinetics[26]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[26]/Ras/GAP /kinetics/chain/kinetics[26]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/Ras/GAP /kinetics/chain/kinetics[26]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/Ras/inact-GEF /kinetics/chain/kinetics[26]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/Ras/CaM-GEF /kinetics/chain/kinetics[26]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca4 /kinetics/chain/kinetics[26]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[26]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[26]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[26]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[25]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[26]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[26]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[26]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[26]/Ras/GDP-Ras /kinetics/chain/kinetics[26]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/Ras/CaM-GEF /kinetics/chain/kinetics[26]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[26]/Ras/CaM-GEF /kinetics/chain/kinetics[26]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/Ras/CaM-GEF /kinetics/chain/kinetics[26]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[26]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[25]/CaM/CaM/diff /kinetics/chain/kinetics[26]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[26]/CaM/CaM/diff /kinetics/chain/kinetics[26]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[26]/CaM/CaM /kinetics/chain/kinetics[26]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/CaM/CaM /kinetics/chain/kinetics[26]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca3 /kinetics/chain/kinetics[26]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca4 /kinetics/chain/kinetics[26]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[26]/Ca /kinetics/chain/kinetics[26]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[26]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[26]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[26]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[26]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca3 /kinetics/chain/kinetics[26]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca3 /kinetics/chain/kinetics[26]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[26]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[26]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[26]/PKM/trigger_PKM /kinetics/chain/kinetics[26]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[26]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[26]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca4 /kinetics/chain/kinetics[26]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca4 /kinetics/chain/kinetics[26]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/CaM/CaM /kinetics/chain/kinetics[26]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca /kinetics/chain/kinetics[26]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[26]/Ca /kinetics/chain/kinetics[26]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[26]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[26]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[26]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[26]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca2 /kinetics/chain/kinetics[26]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca2 /kinetics/chain/kinetics[26]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca3 /kinetics/chain/kinetics[26]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca2 /kinetics/chain/kinetics[26]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/Ca /kinetics/chain/kinetics[26]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca2 /kinetics/chain/kinetics[26]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca /kinetics/chain/kinetics[26]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/Ca /kinetics/chain/kinetics[26]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[26]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[26]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[25]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[26]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[26]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca /kinetics/chain/kinetics[26]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca /kinetics/chain/kinetics[26]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[26]/Ca REAC A B addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[26]/Ca REAC A B addmsg /kinetics/chain/kinetics[26]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[26]/Ca REAC A B addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[26]/Ca REAC A B addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[26]/Ca REAC A B addmsg /kinetics/chain/kinetics[26]/Ca_diff /kinetics/chain/kinetics[26]/Ca REAC B A addmsg /kinetics/chain/kinetics[25]/Ca/diff /kinetics/chain/kinetics[26]/Ca REAC B A addmsg /kinetics/chain/kinetics[26]/Ca/diff /kinetics/chain/kinetics[26]/Ca REAC A B addmsg /kinetics/chain/kinetics[26]/Ca /kinetics/chain/kinetics[26]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/Ca /kinetics/chain/kinetics[26]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/MAPK/craf-1 /kinetics/chain/kinetics[26]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[26]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[26]/Ras/GTP-Ras /kinetics/chain/kinetics[26]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PKM/trigger_PKM /kinetics/chain/kinetics[26]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[25]/PKM/Ca_detector/diff /kinetics/chain/kinetics[26]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[26]/PKM/Ca_detector/diff /kinetics/chain/kinetics[26]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[26]/PKM/Ca_detector /kinetics/chain/kinetics[26]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PKM/Ca_detector /kinetics/chain/kinetics[26]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[26]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[26]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[26]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[26]/PKM/turn_off_activator /kinetics/chain/kinetics[26]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[25]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[26]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[26]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[26]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[26]/PKM/PKM_synthesis /kinetics/chain/kinetics[26]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[26]/PKM/AA_pool /kinetics/chain/kinetics[26]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PKM/PKM_synthesis /kinetics/chain/kinetics[26]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PKM/PKM_synthesis /kinetics/chain/kinetics[26]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[26]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[26]/PKC/PKM-zeta /kinetics/chain/kinetics[26]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PKM/degraded_PKM /kinetics/chain/kinetics[26]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[26]/PKM/PKM_degradation /kinetics/chain/kinetics[26]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[26]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[26]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[26]/PKM/trigger_PKM /kinetics/chain/kinetics[26]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[25]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[26]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[26]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[26]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[26]/PKM/Ca.detector_complex /kinetics/chain/kinetics[26]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[26]/PKM/PKM_activator /kinetics/chain/kinetics[26]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PKM/Ca.detector_complex /kinetics/chain/kinetics[26]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PKM/Ca.detector_complex /kinetics/chain/kinetics[26]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[26]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[26]/PKM/turn_off_activator /kinetics/chain/kinetics[26]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[25]/PKM/PKM_activator/diff /kinetics/chain/kinetics[26]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[26]/PKM/PKM_activator/diff /kinetics/chain/kinetics[26]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[26]/PKM/PKM_activator /kinetics/chain/kinetics[26]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PKM/PKM_activator /kinetics/chain/kinetics[26]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/PKM/PKM_synthesis /kinetics/chain/kinetics[26]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PKM/PKM_activator /kinetics/chain/kinetics[26]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca4 /kinetics/chain/kinetics[26]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PKM/Ca_detector /kinetics/chain/kinetics[26]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[26]/PKM/Ca.detector_complex /kinetics/chain/kinetics[26]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[26]/Ca_diff /kinetics/chain/kinetics[26]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[26]/Ca /kinetics/chain/kinetics[26]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[26]/Ca_input /kinetics/chain/kinetics[26]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[27]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[27]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[27]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[27]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[27]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[26]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[27]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[27]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[27]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[27]/PKC/PKC-Ca /kinetics/chain/kinetics[27]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PKC/PKC-Ca /kinetics/chain/kinetics[27]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/PKC/PKC-Ca /kinetics/chain/kinetics[27]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[27]/PKC/PKC-cytosolic /kinetics/chain/kinetics[27]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/Ca /kinetics/chain/kinetics[27]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PKC/PKC-Ca /kinetics/chain/kinetics[27]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[27]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[27]/DAG /kinetics/chain/kinetics[27]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PKC/PKC-Ca /kinetics/chain/kinetics[27]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[27]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[27]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[27]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[27]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[27]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[27]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[26]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[27]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[27]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[27]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[27]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[27]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[27]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[27]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[26]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[27]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[27]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[27]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[27]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[27]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[27]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[27]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[27]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[27]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[26]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[27]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[27]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[27]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[27]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[27]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[27]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/PKC/PKC-DAG /kinetics/chain/kinetics[27]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[27]/PKC/PKC-cytosolic /kinetics/chain/kinetics[27]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/DAG /kinetics/chain/kinetics[27]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PKC/PKC-n-DAG /kinetics/chain/kinetics[27]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[26]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[27]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[27]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[27]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[27]/PKC/PKC-DAG /kinetics/chain/kinetics[27]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PKC/PKC-DAG /kinetics/chain/kinetics[27]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[27]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[27]/PKC/PKC-n-DAG /kinetics/chain/kinetics[27]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[26]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[27]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[27]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[27]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[27]/PKC/PKC-cytosolic /kinetics/chain/kinetics[27]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PKC/PKC-cytosolic /kinetics/chain/kinetics[27]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[27]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[27]/PKM/PKM_degradation /kinetics/chain/kinetics[27]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[26]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[27]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[27]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[27]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[27]/PKC/PKM-zeta /kinetics/chain/kinetics[27]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PKC/PKM-zeta /kinetics/chain/kinetics[27]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[27]/DAG REAC A B addmsg /kinetics/chain/kinetics[27]/PKC/PKC-n-DAG /kinetics/chain/kinetics[27]/DAG REAC A B addmsg /kinetics/chain/kinetics[27]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[27]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[27]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[27]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[27]/PKC/PKM-zeta /kinetics/chain/kinetics[27]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[27]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[27]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[27]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[27]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[27]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[27]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[27]/PKC-active /kinetics/chain/kinetics[27]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[27]/MAPK/craf-1 /kinetics/chain/kinetics[27]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PKC-active /kinetics/chain/kinetics[27]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[27]/Ras/GAP /kinetics/chain/kinetics[27]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PKC-active /kinetics/chain/kinetics[27]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[27]/Ras/inact-GEF /kinetics/chain/kinetics[27]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[27]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[27]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[27]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[27]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[27]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[26]/MAPK*/diff /kinetics/chain/kinetics[27]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[27]/MAPK*/diff /kinetics/chain/kinetics[27]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[27]/MAPK* /kinetics/chain/kinetics[27]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[27]/MAPK/craf-1* /kinetics/chain/kinetics[27]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/MAPK* /kinetics/chain/kinetics[27]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/MAPK* /kinetics/chain/kinetics[27]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[27]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[27]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[27]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[27]/Ras-act-unphosph-raf /kinetics/chain/kinetics[27]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[26]/MAPK/craf-1/diff /kinetics/chain/kinetics[27]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[27]/MAPK/craf-1/diff /kinetics/chain/kinetics[27]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[27]/MAPK/craf-1 /kinetics/chain/kinetics[27]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/MAPK/craf-1 /kinetics/chain/kinetics[27]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[27]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[27]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[27]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[27]/Ras-act-craf /kinetics/chain/kinetics[27]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[27]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[27]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[27]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[27]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[26]/MAPK/craf-1*/diff /kinetics/chain/kinetics[27]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[27]/MAPK/craf-1*/diff /kinetics/chain/kinetics[27]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[27]/MAPK/craf-1* /kinetics/chain/kinetics[27]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/MAPK/craf-1* /kinetics/chain/kinetics[27]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[27]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[27]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[27]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[27]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[27]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[26]/MAPK/MAPKK/diff /kinetics/chain/kinetics[27]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[27]/MAPK/MAPKK/diff /kinetics/chain/kinetics[27]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[27]/MAPK/MAPKK /kinetics/chain/kinetics[27]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/MAPK/MAPKK /kinetics/chain/kinetics[27]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[27]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[27]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[27]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[26]/MAPK/MAPK/diff /kinetics/chain/kinetics[27]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[27]/MAPK/MAPK/diff /kinetics/chain/kinetics[27]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[27]/MAPK/MAPK /kinetics/chain/kinetics[27]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/MAPK/MAPK /kinetics/chain/kinetics[27]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[27]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[27]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[27]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[26]/MAPK/craf-1**/diff /kinetics/chain/kinetics[27]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[27]/MAPK/craf-1**/diff /kinetics/chain/kinetics[27]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[27]/MAPK/craf-1** /kinetics/chain/kinetics[27]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/MAPK/craf-1** /kinetics/chain/kinetics[27]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[27]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[27]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[27]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[27]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[27]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[27]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[27]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[26]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[27]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[27]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[27]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[27]/MAPK/MAPK-tyr /kinetics/chain/kinetics[27]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/MAPK/MAPK-tyr /kinetics/chain/kinetics[27]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[27]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[27]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[27]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[27]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[27]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[27]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[27]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[27]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[27]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[26]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[27]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[27]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[27]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[27]/MAPK/MAPK /kinetics/chain/kinetics[27]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/MAPK/MAPKK* /kinetics/chain/kinetics[27]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[27]/MAPK/MAPK-tyr /kinetics/chain/kinetics[27]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/MAPK/MAPKK* /kinetics/chain/kinetics[27]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[27]/MAPK/MAPKK* /kinetics/chain/kinetics[27]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/MAPK/MAPKK* /kinetics/chain/kinetics[27]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[27]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[27]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[27]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[27]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[27]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[27]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[27]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[27]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[27]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[27]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[27]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[26]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[27]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[27]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[27]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[27]/MAPK/MAPKK-ser /kinetics/chain/kinetics[27]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/MAPK/MAPKK-ser /kinetics/chain/kinetics[27]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[27]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[27]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[27]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[27]/Ras-act-unphosph-raf /kinetics/chain/kinetics[27]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[26]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[27]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[27]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[27]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[27]/MAPK/MAPKK /kinetics/chain/kinetics[27]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[27]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[27]/MAPK/MAPKK-ser /kinetics/chain/kinetics[27]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[27]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[27]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[27]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[27]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[27]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[27]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[27]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[27]/Ras-act-craf /kinetics/chain/kinetics[27]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[26]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[27]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[27]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[27]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[27]/MAPK/MAPKK /kinetics/chain/kinetics[27]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[27]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[27]/MAPK/MAPKK-ser /kinetics/chain/kinetics[27]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[27]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[27]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[27]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[27]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[27]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[27]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[27]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[26]/MKP-1/diff /kinetics/chain/kinetics[27]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[27]/MKP-1/diff /kinetics/chain/kinetics[27]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[27]/MAPK/MAPK-tyr /kinetics/chain/kinetics[27]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/MKP-1 /kinetics/chain/kinetics[27]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[27]/MAPK* /kinetics/chain/kinetics[27]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/MKP-1 /kinetics/chain/kinetics[27]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[27]/MKP-1 /kinetics/chain/kinetics[27]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/MKP-1 /kinetics/chain/kinetics[27]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/MAPK/craf-1* /kinetics/chain/kinetics[27]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[27]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[27]/Ras/GTP-Ras /kinetics/chain/kinetics[27]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[27]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[27]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[27]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[27]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[27]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[27]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[27]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[26]/PPhosphatase2A/diff /kinetics/chain/kinetics[27]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[27]/PPhosphatase2A/diff /kinetics/chain/kinetics[27]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[27]/MAPK/craf-1* /kinetics/chain/kinetics[27]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PPhosphatase2A /kinetics/chain/kinetics[27]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[27]/MAPK/MAPKK* /kinetics/chain/kinetics[27]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PPhosphatase2A /kinetics/chain/kinetics[27]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[27]/MAPK/MAPKK-ser /kinetics/chain/kinetics[27]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PPhosphatase2A /kinetics/chain/kinetics[27]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[27]/MAPK/craf-1** /kinetics/chain/kinetics[27]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PPhosphatase2A /kinetics/chain/kinetics[27]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[27]/PPhosphatase2A /kinetics/chain/kinetics[27]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PPhosphatase2A /kinetics/chain/kinetics[27]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/Ras/inact-GEF /kinetics/chain/kinetics[27]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[27]/Ras/GEF* /kinetics/chain/kinetics[27]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[27]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[27]/Ras/dephosph-GEF /kinetics/chain/kinetics[27]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[27]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[27]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[27]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[27]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[26]/Ras/inact-GEF/diff /kinetics/chain/kinetics[27]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[27]/Ras/inact-GEF/diff /kinetics/chain/kinetics[27]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[27]/Ras/inact-GEF /kinetics/chain/kinetics[27]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[27]/Ras/GDP-Ras /kinetics/chain/kinetics[27]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/Ras/inact-GEF /kinetics/chain/kinetics[27]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/Ras/inact-GEF /kinetics/chain/kinetics[27]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[27]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[27]/Ras/dephosph-GEF /kinetics/chain/kinetics[27]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[27]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[27]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[26]/Ras/GEF*/diff /kinetics/chain/kinetics[27]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[27]/Ras/GEF*/diff /kinetics/chain/kinetics[27]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[27]/Ras/GEF* /kinetics/chain/kinetics[27]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[27]/Ras/GDP-Ras /kinetics/chain/kinetics[27]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/Ras/GEF* /kinetics/chain/kinetics[27]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/Ras/GEF* /kinetics/chain/kinetics[27]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/Ras-act-craf /kinetics/chain/kinetics[27]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[27]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[27]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[27]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[27]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[27]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[27]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[27]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[27]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[27]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[27]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[27]/Ras-act-unphosph-raf /kinetics/chain/kinetics[27]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[26]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[27]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[27]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[27]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[27]/Ras/GTP-Ras /kinetics/chain/kinetics[27]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/Ras/GTP-Ras /kinetics/chain/kinetics[27]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[27]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[27]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[27]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[27]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[27]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[27]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[27]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[27]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[27]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[26]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[27]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[27]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[27]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[27]/Ras/GDP-Ras /kinetics/chain/kinetics[27]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/Ras/GDP-Ras /kinetics/chain/kinetics[27]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/Ras/GTP-Ras /kinetics/chain/kinetics[27]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/Ras/GDP-Ras /kinetics/chain/kinetics[27]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[27]/Ras/GAP* /kinetics/chain/kinetics[27]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/Ras/GAP /kinetics/chain/kinetics[27]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[27]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[27]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[27]/Ras/dephosph-GAP /kinetics/chain/kinetics[27]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[26]/Ras/GAP*/diff /kinetics/chain/kinetics[27]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[27]/Ras/GAP*/diff /kinetics/chain/kinetics[27]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[27]/Ras/GAP* /kinetics/chain/kinetics[27]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/Ras/GAP* /kinetics/chain/kinetics[27]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[27]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[27]/Ras/dephosph-GAP /kinetics/chain/kinetics[27]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[27]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[27]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[26]/Ras/GAP/diff /kinetics/chain/kinetics[27]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[27]/Ras/GAP/diff /kinetics/chain/kinetics[27]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[27]/Ras/GTP-Ras /kinetics/chain/kinetics[27]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/Ras/GAP /kinetics/chain/kinetics[27]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[27]/Ras/GAP /kinetics/chain/kinetics[27]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/Ras/GAP /kinetics/chain/kinetics[27]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/Ras/inact-GEF /kinetics/chain/kinetics[27]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/Ras/CaM-GEF /kinetics/chain/kinetics[27]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca4 /kinetics/chain/kinetics[27]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[27]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[27]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[27]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[26]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[27]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[27]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[27]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[27]/Ras/GDP-Ras /kinetics/chain/kinetics[27]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/Ras/CaM-GEF /kinetics/chain/kinetics[27]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[27]/Ras/CaM-GEF /kinetics/chain/kinetics[27]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/Ras/CaM-GEF /kinetics/chain/kinetics[27]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[27]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[26]/CaM/CaM/diff /kinetics/chain/kinetics[27]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[27]/CaM/CaM/diff /kinetics/chain/kinetics[27]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[27]/CaM/CaM /kinetics/chain/kinetics[27]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/CaM/CaM /kinetics/chain/kinetics[27]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca3 /kinetics/chain/kinetics[27]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca4 /kinetics/chain/kinetics[27]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[27]/Ca /kinetics/chain/kinetics[27]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[27]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[27]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[27]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[27]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca3 /kinetics/chain/kinetics[27]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca3 /kinetics/chain/kinetics[27]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[27]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[27]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[27]/PKM/trigger_PKM /kinetics/chain/kinetics[27]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[27]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[27]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca4 /kinetics/chain/kinetics[27]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca4 /kinetics/chain/kinetics[27]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/CaM/CaM /kinetics/chain/kinetics[27]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca /kinetics/chain/kinetics[27]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[27]/Ca /kinetics/chain/kinetics[27]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[27]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[27]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[27]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[27]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca2 /kinetics/chain/kinetics[27]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca2 /kinetics/chain/kinetics[27]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca3 /kinetics/chain/kinetics[27]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca2 /kinetics/chain/kinetics[27]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/Ca /kinetics/chain/kinetics[27]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca2 /kinetics/chain/kinetics[27]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca /kinetics/chain/kinetics[27]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/Ca /kinetics/chain/kinetics[27]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[27]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[27]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[26]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[27]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[27]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca /kinetics/chain/kinetics[27]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca /kinetics/chain/kinetics[27]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[27]/Ca REAC A B addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[27]/Ca REAC A B addmsg /kinetics/chain/kinetics[27]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[27]/Ca REAC A B addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[27]/Ca REAC A B addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[27]/Ca REAC A B addmsg /kinetics/chain/kinetics[27]/Ca_diff /kinetics/chain/kinetics[27]/Ca REAC B A addmsg /kinetics/chain/kinetics[26]/Ca/diff /kinetics/chain/kinetics[27]/Ca REAC B A addmsg /kinetics/chain/kinetics[27]/Ca/diff /kinetics/chain/kinetics[27]/Ca REAC A B addmsg /kinetics/chain/kinetics[27]/Ca /kinetics/chain/kinetics[27]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/Ca /kinetics/chain/kinetics[27]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/MAPK/craf-1 /kinetics/chain/kinetics[27]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[27]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[27]/Ras/GTP-Ras /kinetics/chain/kinetics[27]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PKM/trigger_PKM /kinetics/chain/kinetics[27]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[26]/PKM/Ca_detector/diff /kinetics/chain/kinetics[27]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[27]/PKM/Ca_detector/diff /kinetics/chain/kinetics[27]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[27]/PKM/Ca_detector /kinetics/chain/kinetics[27]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PKM/Ca_detector /kinetics/chain/kinetics[27]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[27]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[27]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[27]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[27]/PKM/turn_off_activator /kinetics/chain/kinetics[27]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[26]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[27]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[27]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[27]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[27]/PKM/PKM_synthesis /kinetics/chain/kinetics[27]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[27]/PKM/AA_pool /kinetics/chain/kinetics[27]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PKM/PKM_synthesis /kinetics/chain/kinetics[27]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PKM/PKM_synthesis /kinetics/chain/kinetics[27]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[27]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[27]/PKC/PKM-zeta /kinetics/chain/kinetics[27]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PKM/degraded_PKM /kinetics/chain/kinetics[27]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[27]/PKM/PKM_degradation /kinetics/chain/kinetics[27]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[27]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[27]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[27]/PKM/trigger_PKM /kinetics/chain/kinetics[27]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[26]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[27]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[27]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[27]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[27]/PKM/Ca.detector_complex /kinetics/chain/kinetics[27]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[27]/PKM/PKM_activator /kinetics/chain/kinetics[27]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PKM/Ca.detector_complex /kinetics/chain/kinetics[27]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PKM/Ca.detector_complex /kinetics/chain/kinetics[27]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[27]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[27]/PKM/turn_off_activator /kinetics/chain/kinetics[27]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[26]/PKM/PKM_activator/diff /kinetics/chain/kinetics[27]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[27]/PKM/PKM_activator/diff /kinetics/chain/kinetics[27]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[27]/PKM/PKM_activator /kinetics/chain/kinetics[27]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PKM/PKM_activator /kinetics/chain/kinetics[27]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/PKM/PKM_synthesis /kinetics/chain/kinetics[27]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PKM/PKM_activator /kinetics/chain/kinetics[27]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca4 /kinetics/chain/kinetics[27]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PKM/Ca_detector /kinetics/chain/kinetics[27]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[27]/PKM/Ca.detector_complex /kinetics/chain/kinetics[27]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[27]/Ca_diff /kinetics/chain/kinetics[27]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[27]/Ca /kinetics/chain/kinetics[27]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[27]/Ca_input /kinetics/chain/kinetics[27]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[28]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[28]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[28]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[28]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[28]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[27]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[28]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[28]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[28]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[28]/PKC/PKC-Ca /kinetics/chain/kinetics[28]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PKC/PKC-Ca /kinetics/chain/kinetics[28]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/PKC/PKC-Ca /kinetics/chain/kinetics[28]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[28]/PKC/PKC-cytosolic /kinetics/chain/kinetics[28]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/Ca /kinetics/chain/kinetics[28]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PKC/PKC-Ca /kinetics/chain/kinetics[28]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[28]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[28]/DAG /kinetics/chain/kinetics[28]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PKC/PKC-Ca /kinetics/chain/kinetics[28]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[28]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[28]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[28]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[28]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[28]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[28]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[27]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[28]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[28]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[28]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[28]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[28]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[28]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[28]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[27]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[28]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[28]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[28]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[28]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[28]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[28]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[28]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[28]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[28]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[27]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[28]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[28]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[28]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[28]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[28]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[28]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/PKC/PKC-DAG /kinetics/chain/kinetics[28]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[28]/PKC/PKC-cytosolic /kinetics/chain/kinetics[28]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/DAG /kinetics/chain/kinetics[28]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PKC/PKC-n-DAG /kinetics/chain/kinetics[28]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[27]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[28]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[28]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[28]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[28]/PKC/PKC-DAG /kinetics/chain/kinetics[28]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PKC/PKC-DAG /kinetics/chain/kinetics[28]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[28]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[28]/PKC/PKC-n-DAG /kinetics/chain/kinetics[28]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[27]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[28]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[28]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[28]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[28]/PKC/PKC-cytosolic /kinetics/chain/kinetics[28]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PKC/PKC-cytosolic /kinetics/chain/kinetics[28]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[28]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[28]/PKM/PKM_degradation /kinetics/chain/kinetics[28]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[27]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[28]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[28]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[28]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[28]/PKC/PKM-zeta /kinetics/chain/kinetics[28]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PKC/PKM-zeta /kinetics/chain/kinetics[28]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[28]/DAG REAC A B addmsg /kinetics/chain/kinetics[28]/PKC/PKC-n-DAG /kinetics/chain/kinetics[28]/DAG REAC A B addmsg /kinetics/chain/kinetics[28]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[28]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[28]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[28]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[28]/PKC/PKM-zeta /kinetics/chain/kinetics[28]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[28]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[28]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[28]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[28]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[28]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[28]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[28]/PKC-active /kinetics/chain/kinetics[28]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[28]/MAPK/craf-1 /kinetics/chain/kinetics[28]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PKC-active /kinetics/chain/kinetics[28]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[28]/Ras/GAP /kinetics/chain/kinetics[28]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PKC-active /kinetics/chain/kinetics[28]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[28]/Ras/inact-GEF /kinetics/chain/kinetics[28]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[28]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[28]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[28]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[28]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[28]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[27]/MAPK*/diff /kinetics/chain/kinetics[28]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[28]/MAPK*/diff /kinetics/chain/kinetics[28]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[28]/MAPK* /kinetics/chain/kinetics[28]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[28]/MAPK/craf-1* /kinetics/chain/kinetics[28]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/MAPK* /kinetics/chain/kinetics[28]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/MAPK* /kinetics/chain/kinetics[28]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[28]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[28]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[28]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[28]/Ras-act-unphosph-raf /kinetics/chain/kinetics[28]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[27]/MAPK/craf-1/diff /kinetics/chain/kinetics[28]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[28]/MAPK/craf-1/diff /kinetics/chain/kinetics[28]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[28]/MAPK/craf-1 /kinetics/chain/kinetics[28]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/MAPK/craf-1 /kinetics/chain/kinetics[28]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[28]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[28]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[28]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[28]/Ras-act-craf /kinetics/chain/kinetics[28]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[28]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[28]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[28]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[28]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[27]/MAPK/craf-1*/diff /kinetics/chain/kinetics[28]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[28]/MAPK/craf-1*/diff /kinetics/chain/kinetics[28]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[28]/MAPK/craf-1* /kinetics/chain/kinetics[28]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/MAPK/craf-1* /kinetics/chain/kinetics[28]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[28]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[28]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[28]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[28]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[28]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[27]/MAPK/MAPKK/diff /kinetics/chain/kinetics[28]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[28]/MAPK/MAPKK/diff /kinetics/chain/kinetics[28]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[28]/MAPK/MAPKK /kinetics/chain/kinetics[28]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/MAPK/MAPKK /kinetics/chain/kinetics[28]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[28]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[28]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[28]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[27]/MAPK/MAPK/diff /kinetics/chain/kinetics[28]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[28]/MAPK/MAPK/diff /kinetics/chain/kinetics[28]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[28]/MAPK/MAPK /kinetics/chain/kinetics[28]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/MAPK/MAPK /kinetics/chain/kinetics[28]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[28]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[28]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[28]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[27]/MAPK/craf-1**/diff /kinetics/chain/kinetics[28]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[28]/MAPK/craf-1**/diff /kinetics/chain/kinetics[28]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[28]/MAPK/craf-1** /kinetics/chain/kinetics[28]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/MAPK/craf-1** /kinetics/chain/kinetics[28]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[28]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[28]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[28]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[28]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[28]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[28]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[28]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[27]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[28]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[28]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[28]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[28]/MAPK/MAPK-tyr /kinetics/chain/kinetics[28]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/MAPK/MAPK-tyr /kinetics/chain/kinetics[28]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[28]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[28]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[28]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[28]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[28]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[28]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[28]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[28]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[28]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[27]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[28]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[28]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[28]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[28]/MAPK/MAPK /kinetics/chain/kinetics[28]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/MAPK/MAPKK* /kinetics/chain/kinetics[28]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[28]/MAPK/MAPK-tyr /kinetics/chain/kinetics[28]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/MAPK/MAPKK* /kinetics/chain/kinetics[28]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[28]/MAPK/MAPKK* /kinetics/chain/kinetics[28]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/MAPK/MAPKK* /kinetics/chain/kinetics[28]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[28]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[28]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[28]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[28]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[28]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[28]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[28]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[28]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[28]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[28]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[28]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[27]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[28]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[28]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[28]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[28]/MAPK/MAPKK-ser /kinetics/chain/kinetics[28]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/MAPK/MAPKK-ser /kinetics/chain/kinetics[28]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[28]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[28]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[28]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[28]/Ras-act-unphosph-raf /kinetics/chain/kinetics[28]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[27]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[28]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[28]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[28]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[28]/MAPK/MAPKK /kinetics/chain/kinetics[28]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[28]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[28]/MAPK/MAPKK-ser /kinetics/chain/kinetics[28]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[28]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[28]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[28]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[28]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[28]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[28]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[28]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[28]/Ras-act-craf /kinetics/chain/kinetics[28]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[27]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[28]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[28]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[28]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[28]/MAPK/MAPKK /kinetics/chain/kinetics[28]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[28]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[28]/MAPK/MAPKK-ser /kinetics/chain/kinetics[28]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[28]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[28]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[28]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[28]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[28]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[28]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[28]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[27]/MKP-1/diff /kinetics/chain/kinetics[28]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[28]/MKP-1/diff /kinetics/chain/kinetics[28]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[28]/MAPK/MAPK-tyr /kinetics/chain/kinetics[28]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/MKP-1 /kinetics/chain/kinetics[28]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[28]/MAPK* /kinetics/chain/kinetics[28]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/MKP-1 /kinetics/chain/kinetics[28]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[28]/MKP-1 /kinetics/chain/kinetics[28]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/MKP-1 /kinetics/chain/kinetics[28]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/MAPK/craf-1* /kinetics/chain/kinetics[28]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[28]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[28]/Ras/GTP-Ras /kinetics/chain/kinetics[28]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[28]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[28]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[28]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[28]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[28]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[28]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[28]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[27]/PPhosphatase2A/diff /kinetics/chain/kinetics[28]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[28]/PPhosphatase2A/diff /kinetics/chain/kinetics[28]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[28]/MAPK/craf-1* /kinetics/chain/kinetics[28]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PPhosphatase2A /kinetics/chain/kinetics[28]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[28]/MAPK/MAPKK* /kinetics/chain/kinetics[28]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PPhosphatase2A /kinetics/chain/kinetics[28]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[28]/MAPK/MAPKK-ser /kinetics/chain/kinetics[28]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PPhosphatase2A /kinetics/chain/kinetics[28]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[28]/MAPK/craf-1** /kinetics/chain/kinetics[28]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PPhosphatase2A /kinetics/chain/kinetics[28]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[28]/PPhosphatase2A /kinetics/chain/kinetics[28]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PPhosphatase2A /kinetics/chain/kinetics[28]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/Ras/inact-GEF /kinetics/chain/kinetics[28]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[28]/Ras/GEF* /kinetics/chain/kinetics[28]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[28]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[28]/Ras/dephosph-GEF /kinetics/chain/kinetics[28]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[28]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[28]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[28]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[28]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[27]/Ras/inact-GEF/diff /kinetics/chain/kinetics[28]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[28]/Ras/inact-GEF/diff /kinetics/chain/kinetics[28]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[28]/Ras/inact-GEF /kinetics/chain/kinetics[28]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[28]/Ras/GDP-Ras /kinetics/chain/kinetics[28]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/Ras/inact-GEF /kinetics/chain/kinetics[28]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/Ras/inact-GEF /kinetics/chain/kinetics[28]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[28]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[28]/Ras/dephosph-GEF /kinetics/chain/kinetics[28]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[28]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[28]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[27]/Ras/GEF*/diff /kinetics/chain/kinetics[28]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[28]/Ras/GEF*/diff /kinetics/chain/kinetics[28]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[28]/Ras/GEF* /kinetics/chain/kinetics[28]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[28]/Ras/GDP-Ras /kinetics/chain/kinetics[28]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/Ras/GEF* /kinetics/chain/kinetics[28]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/Ras/GEF* /kinetics/chain/kinetics[28]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/Ras-act-craf /kinetics/chain/kinetics[28]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[28]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[28]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[28]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[28]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[28]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[28]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[28]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[28]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[28]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[28]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[28]/Ras-act-unphosph-raf /kinetics/chain/kinetics[28]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[27]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[28]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[28]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[28]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[28]/Ras/GTP-Ras /kinetics/chain/kinetics[28]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/Ras/GTP-Ras /kinetics/chain/kinetics[28]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[28]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[28]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[28]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[28]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[28]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[28]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[28]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[28]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[28]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[27]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[28]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[28]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[28]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[28]/Ras/GDP-Ras /kinetics/chain/kinetics[28]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/Ras/GDP-Ras /kinetics/chain/kinetics[28]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/Ras/GTP-Ras /kinetics/chain/kinetics[28]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/Ras/GDP-Ras /kinetics/chain/kinetics[28]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[28]/Ras/GAP* /kinetics/chain/kinetics[28]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/Ras/GAP /kinetics/chain/kinetics[28]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[28]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[28]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[28]/Ras/dephosph-GAP /kinetics/chain/kinetics[28]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[27]/Ras/GAP*/diff /kinetics/chain/kinetics[28]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[28]/Ras/GAP*/diff /kinetics/chain/kinetics[28]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[28]/Ras/GAP* /kinetics/chain/kinetics[28]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/Ras/GAP* /kinetics/chain/kinetics[28]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[28]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[28]/Ras/dephosph-GAP /kinetics/chain/kinetics[28]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[28]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[28]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[27]/Ras/GAP/diff /kinetics/chain/kinetics[28]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[28]/Ras/GAP/diff /kinetics/chain/kinetics[28]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[28]/Ras/GTP-Ras /kinetics/chain/kinetics[28]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/Ras/GAP /kinetics/chain/kinetics[28]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[28]/Ras/GAP /kinetics/chain/kinetics[28]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/Ras/GAP /kinetics/chain/kinetics[28]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/Ras/inact-GEF /kinetics/chain/kinetics[28]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/Ras/CaM-GEF /kinetics/chain/kinetics[28]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca4 /kinetics/chain/kinetics[28]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[28]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[28]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[28]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[27]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[28]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[28]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[28]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[28]/Ras/GDP-Ras /kinetics/chain/kinetics[28]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/Ras/CaM-GEF /kinetics/chain/kinetics[28]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[28]/Ras/CaM-GEF /kinetics/chain/kinetics[28]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/Ras/CaM-GEF /kinetics/chain/kinetics[28]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[28]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[27]/CaM/CaM/diff /kinetics/chain/kinetics[28]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[28]/CaM/CaM/diff /kinetics/chain/kinetics[28]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[28]/CaM/CaM /kinetics/chain/kinetics[28]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/CaM/CaM /kinetics/chain/kinetics[28]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca3 /kinetics/chain/kinetics[28]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca4 /kinetics/chain/kinetics[28]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[28]/Ca /kinetics/chain/kinetics[28]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[28]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[28]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[28]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[28]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca3 /kinetics/chain/kinetics[28]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca3 /kinetics/chain/kinetics[28]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[28]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[28]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[28]/PKM/trigger_PKM /kinetics/chain/kinetics[28]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[28]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[28]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca4 /kinetics/chain/kinetics[28]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca4 /kinetics/chain/kinetics[28]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/CaM/CaM /kinetics/chain/kinetics[28]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca /kinetics/chain/kinetics[28]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[28]/Ca /kinetics/chain/kinetics[28]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[28]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[28]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[28]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[28]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca2 /kinetics/chain/kinetics[28]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca2 /kinetics/chain/kinetics[28]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca3 /kinetics/chain/kinetics[28]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca2 /kinetics/chain/kinetics[28]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/Ca /kinetics/chain/kinetics[28]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca2 /kinetics/chain/kinetics[28]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca /kinetics/chain/kinetics[28]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/Ca /kinetics/chain/kinetics[28]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[28]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[28]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[27]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[28]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[28]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca /kinetics/chain/kinetics[28]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca /kinetics/chain/kinetics[28]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[28]/Ca REAC A B addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[28]/Ca REAC A B addmsg /kinetics/chain/kinetics[28]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[28]/Ca REAC A B addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[28]/Ca REAC A B addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[28]/Ca REAC A B addmsg /kinetics/chain/kinetics[28]/Ca_diff /kinetics/chain/kinetics[28]/Ca REAC B A addmsg /kinetics/chain/kinetics[27]/Ca/diff /kinetics/chain/kinetics[28]/Ca REAC B A addmsg /kinetics/chain/kinetics[28]/Ca/diff /kinetics/chain/kinetics[28]/Ca REAC A B addmsg /kinetics/chain/kinetics[28]/Ca /kinetics/chain/kinetics[28]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/Ca /kinetics/chain/kinetics[28]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/MAPK/craf-1 /kinetics/chain/kinetics[28]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[28]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[28]/Ras/GTP-Ras /kinetics/chain/kinetics[28]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PKM/trigger_PKM /kinetics/chain/kinetics[28]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[27]/PKM/Ca_detector/diff /kinetics/chain/kinetics[28]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[28]/PKM/Ca_detector/diff /kinetics/chain/kinetics[28]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[28]/PKM/Ca_detector /kinetics/chain/kinetics[28]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PKM/Ca_detector /kinetics/chain/kinetics[28]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[28]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[28]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[28]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[28]/PKM/turn_off_activator /kinetics/chain/kinetics[28]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[27]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[28]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[28]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[28]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[28]/PKM/PKM_synthesis /kinetics/chain/kinetics[28]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[28]/PKM/AA_pool /kinetics/chain/kinetics[28]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PKM/PKM_synthesis /kinetics/chain/kinetics[28]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PKM/PKM_synthesis /kinetics/chain/kinetics[28]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[28]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[28]/PKC/PKM-zeta /kinetics/chain/kinetics[28]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PKM/degraded_PKM /kinetics/chain/kinetics[28]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[28]/PKM/PKM_degradation /kinetics/chain/kinetics[28]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[28]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[28]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[28]/PKM/trigger_PKM /kinetics/chain/kinetics[28]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[27]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[28]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[28]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[28]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[28]/PKM/Ca.detector_complex /kinetics/chain/kinetics[28]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[28]/PKM/PKM_activator /kinetics/chain/kinetics[28]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PKM/Ca.detector_complex /kinetics/chain/kinetics[28]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PKM/Ca.detector_complex /kinetics/chain/kinetics[28]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[28]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[28]/PKM/turn_off_activator /kinetics/chain/kinetics[28]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[27]/PKM/PKM_activator/diff /kinetics/chain/kinetics[28]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[28]/PKM/PKM_activator/diff /kinetics/chain/kinetics[28]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[28]/PKM/PKM_activator /kinetics/chain/kinetics[28]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PKM/PKM_activator /kinetics/chain/kinetics[28]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/PKM/PKM_synthesis /kinetics/chain/kinetics[28]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PKM/PKM_activator /kinetics/chain/kinetics[28]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca4 /kinetics/chain/kinetics[28]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PKM/Ca_detector /kinetics/chain/kinetics[28]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[28]/PKM/Ca.detector_complex /kinetics/chain/kinetics[28]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[28]/Ca_diff /kinetics/chain/kinetics[28]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[28]/Ca /kinetics/chain/kinetics[28]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[28]/Ca_input /kinetics/chain/kinetics[28]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[29]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[29]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[29]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[29]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[29]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[28]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[29]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[29]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[29]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[29]/PKC/PKC-Ca /kinetics/chain/kinetics[29]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PKC/PKC-Ca /kinetics/chain/kinetics[29]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/PKC/PKC-Ca /kinetics/chain/kinetics[29]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[29]/PKC/PKC-cytosolic /kinetics/chain/kinetics[29]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/Ca /kinetics/chain/kinetics[29]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PKC/PKC-Ca /kinetics/chain/kinetics[29]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[29]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[29]/DAG /kinetics/chain/kinetics[29]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PKC/PKC-Ca /kinetics/chain/kinetics[29]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[29]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[29]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[29]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[29]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[29]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[29]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[28]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[29]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[29]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[29]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[29]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[29]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[29]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[29]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[28]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[29]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[29]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[29]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[29]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[29]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[29]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[29]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[29]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[29]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[28]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[29]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[29]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[29]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[29]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[29]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[29]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/PKC/PKC-DAG /kinetics/chain/kinetics[29]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[29]/PKC/PKC-cytosolic /kinetics/chain/kinetics[29]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/DAG /kinetics/chain/kinetics[29]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PKC/PKC-n-DAG /kinetics/chain/kinetics[29]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[28]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[29]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[29]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[29]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[29]/PKC/PKC-DAG /kinetics/chain/kinetics[29]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PKC/PKC-DAG /kinetics/chain/kinetics[29]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[29]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[29]/PKC/PKC-n-DAG /kinetics/chain/kinetics[29]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[28]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[29]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[29]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[29]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[29]/PKC/PKC-cytosolic /kinetics/chain/kinetics[29]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PKC/PKC-cytosolic /kinetics/chain/kinetics[29]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[29]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[29]/PKM/PKM_degradation /kinetics/chain/kinetics[29]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[28]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[29]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[29]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[29]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[29]/PKC/PKM-zeta /kinetics/chain/kinetics[29]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PKC/PKM-zeta /kinetics/chain/kinetics[29]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[29]/DAG REAC A B addmsg /kinetics/chain/kinetics[29]/PKC/PKC-n-DAG /kinetics/chain/kinetics[29]/DAG REAC A B addmsg /kinetics/chain/kinetics[29]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[29]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[29]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[29]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[29]/PKC/PKM-zeta /kinetics/chain/kinetics[29]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[29]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[29]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[29]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[29]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[29]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[29]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[29]/PKC-active /kinetics/chain/kinetics[29]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[29]/MAPK/craf-1 /kinetics/chain/kinetics[29]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PKC-active /kinetics/chain/kinetics[29]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[29]/Ras/GAP /kinetics/chain/kinetics[29]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PKC-active /kinetics/chain/kinetics[29]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[29]/Ras/inact-GEF /kinetics/chain/kinetics[29]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[29]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[29]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[29]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[29]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[29]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[28]/MAPK*/diff /kinetics/chain/kinetics[29]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[29]/MAPK*/diff /kinetics/chain/kinetics[29]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[29]/MAPK* /kinetics/chain/kinetics[29]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[29]/MAPK/craf-1* /kinetics/chain/kinetics[29]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/MAPK* /kinetics/chain/kinetics[29]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/MAPK* /kinetics/chain/kinetics[29]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[29]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[29]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[29]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[29]/Ras-act-unphosph-raf /kinetics/chain/kinetics[29]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[28]/MAPK/craf-1/diff /kinetics/chain/kinetics[29]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[29]/MAPK/craf-1/diff /kinetics/chain/kinetics[29]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[29]/MAPK/craf-1 /kinetics/chain/kinetics[29]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/MAPK/craf-1 /kinetics/chain/kinetics[29]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[29]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[29]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[29]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[29]/Ras-act-craf /kinetics/chain/kinetics[29]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[29]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[29]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[29]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[29]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[28]/MAPK/craf-1*/diff /kinetics/chain/kinetics[29]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[29]/MAPK/craf-1*/diff /kinetics/chain/kinetics[29]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[29]/MAPK/craf-1* /kinetics/chain/kinetics[29]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/MAPK/craf-1* /kinetics/chain/kinetics[29]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[29]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[29]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[29]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[29]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[29]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[28]/MAPK/MAPKK/diff /kinetics/chain/kinetics[29]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[29]/MAPK/MAPKK/diff /kinetics/chain/kinetics[29]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[29]/MAPK/MAPKK /kinetics/chain/kinetics[29]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/MAPK/MAPKK /kinetics/chain/kinetics[29]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[29]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[29]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[29]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[28]/MAPK/MAPK/diff /kinetics/chain/kinetics[29]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[29]/MAPK/MAPK/diff /kinetics/chain/kinetics[29]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[29]/MAPK/MAPK /kinetics/chain/kinetics[29]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/MAPK/MAPK /kinetics/chain/kinetics[29]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[29]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[29]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[29]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[28]/MAPK/craf-1**/diff /kinetics/chain/kinetics[29]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[29]/MAPK/craf-1**/diff /kinetics/chain/kinetics[29]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[29]/MAPK/craf-1** /kinetics/chain/kinetics[29]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/MAPK/craf-1** /kinetics/chain/kinetics[29]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[29]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[29]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[29]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[29]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[29]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[29]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[29]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[28]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[29]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[29]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[29]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[29]/MAPK/MAPK-tyr /kinetics/chain/kinetics[29]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/MAPK/MAPK-tyr /kinetics/chain/kinetics[29]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[29]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[29]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[29]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[29]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[29]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[29]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[29]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[29]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[29]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[28]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[29]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[29]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[29]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[29]/MAPK/MAPK /kinetics/chain/kinetics[29]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/MAPK/MAPKK* /kinetics/chain/kinetics[29]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[29]/MAPK/MAPK-tyr /kinetics/chain/kinetics[29]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/MAPK/MAPKK* /kinetics/chain/kinetics[29]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[29]/MAPK/MAPKK* /kinetics/chain/kinetics[29]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/MAPK/MAPKK* /kinetics/chain/kinetics[29]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[29]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[29]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[29]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[29]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[29]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[29]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[29]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[29]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[29]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[29]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[29]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[28]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[29]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[29]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[29]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[29]/MAPK/MAPKK-ser /kinetics/chain/kinetics[29]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/MAPK/MAPKK-ser /kinetics/chain/kinetics[29]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[29]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[29]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[29]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[29]/Ras-act-unphosph-raf /kinetics/chain/kinetics[29]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[28]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[29]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[29]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[29]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[29]/MAPK/MAPKK /kinetics/chain/kinetics[29]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[29]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[29]/MAPK/MAPKK-ser /kinetics/chain/kinetics[29]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[29]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[29]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[29]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[29]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[29]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[29]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[29]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[29]/Ras-act-craf /kinetics/chain/kinetics[29]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[28]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[29]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[29]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[29]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[29]/MAPK/MAPKK /kinetics/chain/kinetics[29]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[29]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[29]/MAPK/MAPKK-ser /kinetics/chain/kinetics[29]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[29]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[29]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[29]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[29]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[29]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[29]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[29]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[28]/MKP-1/diff /kinetics/chain/kinetics[29]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[29]/MKP-1/diff /kinetics/chain/kinetics[29]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[29]/MAPK/MAPK-tyr /kinetics/chain/kinetics[29]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/MKP-1 /kinetics/chain/kinetics[29]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[29]/MAPK* /kinetics/chain/kinetics[29]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/MKP-1 /kinetics/chain/kinetics[29]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[29]/MKP-1 /kinetics/chain/kinetics[29]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/MKP-1 /kinetics/chain/kinetics[29]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/MAPK/craf-1* /kinetics/chain/kinetics[29]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[29]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[29]/Ras/GTP-Ras /kinetics/chain/kinetics[29]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[29]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[29]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[29]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[29]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[29]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[29]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[29]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[28]/PPhosphatase2A/diff /kinetics/chain/kinetics[29]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[29]/PPhosphatase2A/diff /kinetics/chain/kinetics[29]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[29]/MAPK/craf-1* /kinetics/chain/kinetics[29]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PPhosphatase2A /kinetics/chain/kinetics[29]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[29]/MAPK/MAPKK* /kinetics/chain/kinetics[29]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PPhosphatase2A /kinetics/chain/kinetics[29]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[29]/MAPK/MAPKK-ser /kinetics/chain/kinetics[29]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PPhosphatase2A /kinetics/chain/kinetics[29]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[29]/MAPK/craf-1** /kinetics/chain/kinetics[29]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PPhosphatase2A /kinetics/chain/kinetics[29]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[29]/PPhosphatase2A /kinetics/chain/kinetics[29]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PPhosphatase2A /kinetics/chain/kinetics[29]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/Ras/inact-GEF /kinetics/chain/kinetics[29]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[29]/Ras/GEF* /kinetics/chain/kinetics[29]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[29]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[29]/Ras/dephosph-GEF /kinetics/chain/kinetics[29]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[29]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[29]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[29]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[29]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[28]/Ras/inact-GEF/diff /kinetics/chain/kinetics[29]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[29]/Ras/inact-GEF/diff /kinetics/chain/kinetics[29]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[29]/Ras/inact-GEF /kinetics/chain/kinetics[29]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[29]/Ras/GDP-Ras /kinetics/chain/kinetics[29]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/Ras/inact-GEF /kinetics/chain/kinetics[29]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/Ras/inact-GEF /kinetics/chain/kinetics[29]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[29]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[29]/Ras/dephosph-GEF /kinetics/chain/kinetics[29]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[29]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[29]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[28]/Ras/GEF*/diff /kinetics/chain/kinetics[29]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[29]/Ras/GEF*/diff /kinetics/chain/kinetics[29]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[29]/Ras/GEF* /kinetics/chain/kinetics[29]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[29]/Ras/GDP-Ras /kinetics/chain/kinetics[29]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/Ras/GEF* /kinetics/chain/kinetics[29]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/Ras/GEF* /kinetics/chain/kinetics[29]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/Ras-act-craf /kinetics/chain/kinetics[29]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[29]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[29]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[29]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[29]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[29]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[29]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[29]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[29]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[29]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[29]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[29]/Ras-act-unphosph-raf /kinetics/chain/kinetics[29]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[28]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[29]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[29]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[29]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[29]/Ras/GTP-Ras /kinetics/chain/kinetics[29]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/Ras/GTP-Ras /kinetics/chain/kinetics[29]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[29]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[29]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[29]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[29]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[29]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[29]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[29]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[29]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[29]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[28]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[29]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[29]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[29]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[29]/Ras/GDP-Ras /kinetics/chain/kinetics[29]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/Ras/GDP-Ras /kinetics/chain/kinetics[29]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/Ras/GTP-Ras /kinetics/chain/kinetics[29]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/Ras/GDP-Ras /kinetics/chain/kinetics[29]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[29]/Ras/GAP* /kinetics/chain/kinetics[29]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/Ras/GAP /kinetics/chain/kinetics[29]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[29]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[29]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[29]/Ras/dephosph-GAP /kinetics/chain/kinetics[29]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[28]/Ras/GAP*/diff /kinetics/chain/kinetics[29]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[29]/Ras/GAP*/diff /kinetics/chain/kinetics[29]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[29]/Ras/GAP* /kinetics/chain/kinetics[29]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/Ras/GAP* /kinetics/chain/kinetics[29]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[29]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[29]/Ras/dephosph-GAP /kinetics/chain/kinetics[29]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[29]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[29]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[28]/Ras/GAP/diff /kinetics/chain/kinetics[29]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[29]/Ras/GAP/diff /kinetics/chain/kinetics[29]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[29]/Ras/GTP-Ras /kinetics/chain/kinetics[29]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/Ras/GAP /kinetics/chain/kinetics[29]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[29]/Ras/GAP /kinetics/chain/kinetics[29]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/Ras/GAP /kinetics/chain/kinetics[29]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/Ras/inact-GEF /kinetics/chain/kinetics[29]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/Ras/CaM-GEF /kinetics/chain/kinetics[29]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca4 /kinetics/chain/kinetics[29]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[29]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[29]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[29]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[28]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[29]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[29]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[29]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[29]/Ras/GDP-Ras /kinetics/chain/kinetics[29]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/Ras/CaM-GEF /kinetics/chain/kinetics[29]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[29]/Ras/CaM-GEF /kinetics/chain/kinetics[29]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/Ras/CaM-GEF /kinetics/chain/kinetics[29]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[29]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[28]/CaM/CaM/diff /kinetics/chain/kinetics[29]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[29]/CaM/CaM/diff /kinetics/chain/kinetics[29]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[29]/CaM/CaM /kinetics/chain/kinetics[29]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/CaM/CaM /kinetics/chain/kinetics[29]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca3 /kinetics/chain/kinetics[29]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca4 /kinetics/chain/kinetics[29]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[29]/Ca /kinetics/chain/kinetics[29]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[29]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[29]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[29]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[29]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca3 /kinetics/chain/kinetics[29]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca3 /kinetics/chain/kinetics[29]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[29]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[29]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[29]/PKM/trigger_PKM /kinetics/chain/kinetics[29]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[29]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[29]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca4 /kinetics/chain/kinetics[29]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca4 /kinetics/chain/kinetics[29]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/CaM/CaM /kinetics/chain/kinetics[29]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca /kinetics/chain/kinetics[29]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[29]/Ca /kinetics/chain/kinetics[29]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[29]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[29]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[29]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[29]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca2 /kinetics/chain/kinetics[29]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca2 /kinetics/chain/kinetics[29]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca3 /kinetics/chain/kinetics[29]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca2 /kinetics/chain/kinetics[29]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/Ca /kinetics/chain/kinetics[29]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca2 /kinetics/chain/kinetics[29]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca /kinetics/chain/kinetics[29]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/Ca /kinetics/chain/kinetics[29]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[29]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[29]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[28]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[29]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[29]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca /kinetics/chain/kinetics[29]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca /kinetics/chain/kinetics[29]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[29]/Ca REAC A B addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[29]/Ca REAC A B addmsg /kinetics/chain/kinetics[29]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[29]/Ca REAC A B addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[29]/Ca REAC A B addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[29]/Ca REAC A B addmsg /kinetics/chain/kinetics[29]/Ca_diff /kinetics/chain/kinetics[29]/Ca REAC B A addmsg /kinetics/chain/kinetics[28]/Ca/diff /kinetics/chain/kinetics[29]/Ca REAC B A addmsg /kinetics/chain/kinetics[29]/Ca/diff /kinetics/chain/kinetics[29]/Ca REAC A B addmsg /kinetics/chain/kinetics[29]/Ca /kinetics/chain/kinetics[29]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/Ca /kinetics/chain/kinetics[29]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/MAPK/craf-1 /kinetics/chain/kinetics[29]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[29]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[29]/Ras/GTP-Ras /kinetics/chain/kinetics[29]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PKM/trigger_PKM /kinetics/chain/kinetics[29]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[28]/PKM/Ca_detector/diff /kinetics/chain/kinetics[29]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[29]/PKM/Ca_detector/diff /kinetics/chain/kinetics[29]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[29]/PKM/Ca_detector /kinetics/chain/kinetics[29]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PKM/Ca_detector /kinetics/chain/kinetics[29]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[29]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[29]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[29]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[29]/PKM/turn_off_activator /kinetics/chain/kinetics[29]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[28]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[29]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[29]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[29]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[29]/PKM/PKM_synthesis /kinetics/chain/kinetics[29]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[29]/PKM/AA_pool /kinetics/chain/kinetics[29]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PKM/PKM_synthesis /kinetics/chain/kinetics[29]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PKM/PKM_synthesis /kinetics/chain/kinetics[29]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[29]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[29]/PKC/PKM-zeta /kinetics/chain/kinetics[29]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PKM/degraded_PKM /kinetics/chain/kinetics[29]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[29]/PKM/PKM_degradation /kinetics/chain/kinetics[29]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[29]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[29]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[29]/PKM/trigger_PKM /kinetics/chain/kinetics[29]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[28]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[29]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[29]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[29]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[29]/PKM/Ca.detector_complex /kinetics/chain/kinetics[29]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[29]/PKM/PKM_activator /kinetics/chain/kinetics[29]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PKM/Ca.detector_complex /kinetics/chain/kinetics[29]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PKM/Ca.detector_complex /kinetics/chain/kinetics[29]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[29]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[29]/PKM/turn_off_activator /kinetics/chain/kinetics[29]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[28]/PKM/PKM_activator/diff /kinetics/chain/kinetics[29]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[29]/PKM/PKM_activator/diff /kinetics/chain/kinetics[29]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[29]/PKM/PKM_activator /kinetics/chain/kinetics[29]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PKM/PKM_activator /kinetics/chain/kinetics[29]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/PKM/PKM_synthesis /kinetics/chain/kinetics[29]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PKM/PKM_activator /kinetics/chain/kinetics[29]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca4 /kinetics/chain/kinetics[29]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PKM/Ca_detector /kinetics/chain/kinetics[29]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[29]/PKM/Ca.detector_complex /kinetics/chain/kinetics[29]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[29]/Ca_diff /kinetics/chain/kinetics[29]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[29]/Ca /kinetics/chain/kinetics[29]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[29]/Ca_input /kinetics/chain/kinetics[29]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[30]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[30]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[30]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[30]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[30]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[29]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[30]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[30]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[30]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[30]/PKC/PKC-Ca /kinetics/chain/kinetics[30]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PKC/PKC-Ca /kinetics/chain/kinetics[30]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/PKC/PKC-Ca /kinetics/chain/kinetics[30]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[30]/PKC/PKC-cytosolic /kinetics/chain/kinetics[30]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/Ca /kinetics/chain/kinetics[30]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PKC/PKC-Ca /kinetics/chain/kinetics[30]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[30]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[30]/DAG /kinetics/chain/kinetics[30]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PKC/PKC-Ca /kinetics/chain/kinetics[30]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[30]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[30]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[30]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[30]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[30]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[30]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[29]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[30]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[30]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[30]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[30]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[30]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[30]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[30]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[29]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[30]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[30]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[30]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[30]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[30]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[30]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[30]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[30]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[30]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[29]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[30]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[30]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[30]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[30]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[30]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[30]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/PKC/PKC-DAG /kinetics/chain/kinetics[30]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[30]/PKC/PKC-cytosolic /kinetics/chain/kinetics[30]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/DAG /kinetics/chain/kinetics[30]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PKC/PKC-n-DAG /kinetics/chain/kinetics[30]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[29]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[30]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[30]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[30]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[30]/PKC/PKC-DAG /kinetics/chain/kinetics[30]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PKC/PKC-DAG /kinetics/chain/kinetics[30]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[30]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[30]/PKC/PKC-n-DAG /kinetics/chain/kinetics[30]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[29]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[30]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[30]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[30]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[30]/PKC/PKC-cytosolic /kinetics/chain/kinetics[30]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PKC/PKC-cytosolic /kinetics/chain/kinetics[30]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[30]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[30]/PKM/PKM_degradation /kinetics/chain/kinetics[30]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[29]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[30]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[30]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[30]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[30]/PKC/PKM-zeta /kinetics/chain/kinetics[30]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PKC/PKM-zeta /kinetics/chain/kinetics[30]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[30]/DAG REAC A B addmsg /kinetics/chain/kinetics[30]/PKC/PKC-n-DAG /kinetics/chain/kinetics[30]/DAG REAC A B addmsg /kinetics/chain/kinetics[30]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[30]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[30]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[30]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[30]/PKC/PKM-zeta /kinetics/chain/kinetics[30]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[30]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[30]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[30]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[30]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[30]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[30]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[30]/PKC-active /kinetics/chain/kinetics[30]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[30]/MAPK/craf-1 /kinetics/chain/kinetics[30]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PKC-active /kinetics/chain/kinetics[30]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[30]/Ras/GAP /kinetics/chain/kinetics[30]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PKC-active /kinetics/chain/kinetics[30]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[30]/Ras/inact-GEF /kinetics/chain/kinetics[30]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[30]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[30]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[30]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[30]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[30]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[29]/MAPK*/diff /kinetics/chain/kinetics[30]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[30]/MAPK*/diff /kinetics/chain/kinetics[30]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[30]/MAPK* /kinetics/chain/kinetics[30]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[30]/MAPK/craf-1* /kinetics/chain/kinetics[30]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/MAPK* /kinetics/chain/kinetics[30]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/MAPK* /kinetics/chain/kinetics[30]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[30]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[30]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[30]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[30]/Ras-act-unphosph-raf /kinetics/chain/kinetics[30]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[29]/MAPK/craf-1/diff /kinetics/chain/kinetics[30]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[30]/MAPK/craf-1/diff /kinetics/chain/kinetics[30]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[30]/MAPK/craf-1 /kinetics/chain/kinetics[30]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/MAPK/craf-1 /kinetics/chain/kinetics[30]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[30]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[30]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[30]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[30]/Ras-act-craf /kinetics/chain/kinetics[30]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[30]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[30]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[30]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[30]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[29]/MAPK/craf-1*/diff /kinetics/chain/kinetics[30]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[30]/MAPK/craf-1*/diff /kinetics/chain/kinetics[30]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[30]/MAPK/craf-1* /kinetics/chain/kinetics[30]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/MAPK/craf-1* /kinetics/chain/kinetics[30]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[30]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[30]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[30]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[30]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[30]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[29]/MAPK/MAPKK/diff /kinetics/chain/kinetics[30]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[30]/MAPK/MAPKK/diff /kinetics/chain/kinetics[30]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[30]/MAPK/MAPKK /kinetics/chain/kinetics[30]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/MAPK/MAPKK /kinetics/chain/kinetics[30]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[30]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[30]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[30]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[29]/MAPK/MAPK/diff /kinetics/chain/kinetics[30]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[30]/MAPK/MAPK/diff /kinetics/chain/kinetics[30]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[30]/MAPK/MAPK /kinetics/chain/kinetics[30]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/MAPK/MAPK /kinetics/chain/kinetics[30]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[30]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[30]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[30]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[29]/MAPK/craf-1**/diff /kinetics/chain/kinetics[30]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[30]/MAPK/craf-1**/diff /kinetics/chain/kinetics[30]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[30]/MAPK/craf-1** /kinetics/chain/kinetics[30]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/MAPK/craf-1** /kinetics/chain/kinetics[30]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[30]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[30]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[30]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[30]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[30]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[30]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[30]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[29]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[30]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[30]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[30]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[30]/MAPK/MAPK-tyr /kinetics/chain/kinetics[30]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/MAPK/MAPK-tyr /kinetics/chain/kinetics[30]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[30]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[30]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[30]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[30]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[30]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[30]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[30]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[30]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[30]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[29]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[30]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[30]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[30]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[30]/MAPK/MAPK /kinetics/chain/kinetics[30]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/MAPK/MAPKK* /kinetics/chain/kinetics[30]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[30]/MAPK/MAPK-tyr /kinetics/chain/kinetics[30]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/MAPK/MAPKK* /kinetics/chain/kinetics[30]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[30]/MAPK/MAPKK* /kinetics/chain/kinetics[30]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/MAPK/MAPKK* /kinetics/chain/kinetics[30]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[30]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[30]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[30]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[30]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[30]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[30]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[30]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[30]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[30]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[30]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[30]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[29]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[30]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[30]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[30]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[30]/MAPK/MAPKK-ser /kinetics/chain/kinetics[30]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/MAPK/MAPKK-ser /kinetics/chain/kinetics[30]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[30]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[30]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[30]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[30]/Ras-act-unphosph-raf /kinetics/chain/kinetics[30]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[29]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[30]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[30]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[30]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[30]/MAPK/MAPKK /kinetics/chain/kinetics[30]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[30]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[30]/MAPK/MAPKK-ser /kinetics/chain/kinetics[30]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[30]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[30]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[30]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[30]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[30]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[30]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[30]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[30]/Ras-act-craf /kinetics/chain/kinetics[30]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[29]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[30]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[30]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[30]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[30]/MAPK/MAPKK /kinetics/chain/kinetics[30]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[30]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[30]/MAPK/MAPKK-ser /kinetics/chain/kinetics[30]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[30]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[30]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[30]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[30]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[30]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[30]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[30]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[29]/MKP-1/diff /kinetics/chain/kinetics[30]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[30]/MKP-1/diff /kinetics/chain/kinetics[30]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[30]/MAPK/MAPK-tyr /kinetics/chain/kinetics[30]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/MKP-1 /kinetics/chain/kinetics[30]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[30]/MAPK* /kinetics/chain/kinetics[30]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/MKP-1 /kinetics/chain/kinetics[30]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[30]/MKP-1 /kinetics/chain/kinetics[30]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/MKP-1 /kinetics/chain/kinetics[30]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/MAPK/craf-1* /kinetics/chain/kinetics[30]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[30]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[30]/Ras/GTP-Ras /kinetics/chain/kinetics[30]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[30]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[30]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[30]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[30]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[30]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[30]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[30]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[29]/PPhosphatase2A/diff /kinetics/chain/kinetics[30]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[30]/PPhosphatase2A/diff /kinetics/chain/kinetics[30]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[30]/MAPK/craf-1* /kinetics/chain/kinetics[30]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PPhosphatase2A /kinetics/chain/kinetics[30]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[30]/MAPK/MAPKK* /kinetics/chain/kinetics[30]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PPhosphatase2A /kinetics/chain/kinetics[30]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[30]/MAPK/MAPKK-ser /kinetics/chain/kinetics[30]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PPhosphatase2A /kinetics/chain/kinetics[30]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[30]/MAPK/craf-1** /kinetics/chain/kinetics[30]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PPhosphatase2A /kinetics/chain/kinetics[30]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[30]/PPhosphatase2A /kinetics/chain/kinetics[30]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PPhosphatase2A /kinetics/chain/kinetics[30]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/Ras/inact-GEF /kinetics/chain/kinetics[30]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[30]/Ras/GEF* /kinetics/chain/kinetics[30]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[30]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[30]/Ras/dephosph-GEF /kinetics/chain/kinetics[30]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[30]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[30]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[30]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[30]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[29]/Ras/inact-GEF/diff /kinetics/chain/kinetics[30]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[30]/Ras/inact-GEF/diff /kinetics/chain/kinetics[30]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[30]/Ras/inact-GEF /kinetics/chain/kinetics[30]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[30]/Ras/GDP-Ras /kinetics/chain/kinetics[30]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/Ras/inact-GEF /kinetics/chain/kinetics[30]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/Ras/inact-GEF /kinetics/chain/kinetics[30]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[30]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[30]/Ras/dephosph-GEF /kinetics/chain/kinetics[30]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[30]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[30]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[29]/Ras/GEF*/diff /kinetics/chain/kinetics[30]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[30]/Ras/GEF*/diff /kinetics/chain/kinetics[30]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[30]/Ras/GEF* /kinetics/chain/kinetics[30]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[30]/Ras/GDP-Ras /kinetics/chain/kinetics[30]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/Ras/GEF* /kinetics/chain/kinetics[30]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/Ras/GEF* /kinetics/chain/kinetics[30]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/Ras-act-craf /kinetics/chain/kinetics[30]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[30]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[30]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[30]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[30]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[30]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[30]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[30]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[30]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[30]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[30]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[30]/Ras-act-unphosph-raf /kinetics/chain/kinetics[30]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[29]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[30]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[30]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[30]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[30]/Ras/GTP-Ras /kinetics/chain/kinetics[30]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/Ras/GTP-Ras /kinetics/chain/kinetics[30]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[30]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[30]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[30]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[30]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[30]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[30]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[30]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[30]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[30]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[29]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[30]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[30]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[30]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[30]/Ras/GDP-Ras /kinetics/chain/kinetics[30]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/Ras/GDP-Ras /kinetics/chain/kinetics[30]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/Ras/GTP-Ras /kinetics/chain/kinetics[30]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/Ras/GDP-Ras /kinetics/chain/kinetics[30]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[30]/Ras/GAP* /kinetics/chain/kinetics[30]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/Ras/GAP /kinetics/chain/kinetics[30]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[30]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[30]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[30]/Ras/dephosph-GAP /kinetics/chain/kinetics[30]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[29]/Ras/GAP*/diff /kinetics/chain/kinetics[30]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[30]/Ras/GAP*/diff /kinetics/chain/kinetics[30]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[30]/Ras/GAP* /kinetics/chain/kinetics[30]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/Ras/GAP* /kinetics/chain/kinetics[30]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[30]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[30]/Ras/dephosph-GAP /kinetics/chain/kinetics[30]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[30]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[30]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[29]/Ras/GAP/diff /kinetics/chain/kinetics[30]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[30]/Ras/GAP/diff /kinetics/chain/kinetics[30]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[30]/Ras/GTP-Ras /kinetics/chain/kinetics[30]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/Ras/GAP /kinetics/chain/kinetics[30]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[30]/Ras/GAP /kinetics/chain/kinetics[30]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/Ras/GAP /kinetics/chain/kinetics[30]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/Ras/inact-GEF /kinetics/chain/kinetics[30]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/Ras/CaM-GEF /kinetics/chain/kinetics[30]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca4 /kinetics/chain/kinetics[30]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[30]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[30]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[30]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[29]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[30]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[30]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[30]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[30]/Ras/GDP-Ras /kinetics/chain/kinetics[30]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/Ras/CaM-GEF /kinetics/chain/kinetics[30]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[30]/Ras/CaM-GEF /kinetics/chain/kinetics[30]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/Ras/CaM-GEF /kinetics/chain/kinetics[30]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[30]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[29]/CaM/CaM/diff /kinetics/chain/kinetics[30]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[30]/CaM/CaM/diff /kinetics/chain/kinetics[30]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[30]/CaM/CaM /kinetics/chain/kinetics[30]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/CaM/CaM /kinetics/chain/kinetics[30]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca3 /kinetics/chain/kinetics[30]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca4 /kinetics/chain/kinetics[30]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[30]/Ca /kinetics/chain/kinetics[30]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[30]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[30]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[30]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[30]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca3 /kinetics/chain/kinetics[30]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca3 /kinetics/chain/kinetics[30]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[30]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[30]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[30]/PKM/trigger_PKM /kinetics/chain/kinetics[30]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[30]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[30]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca4 /kinetics/chain/kinetics[30]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca4 /kinetics/chain/kinetics[30]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/CaM/CaM /kinetics/chain/kinetics[30]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca /kinetics/chain/kinetics[30]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[30]/Ca /kinetics/chain/kinetics[30]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[30]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[30]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[30]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[30]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca2 /kinetics/chain/kinetics[30]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca2 /kinetics/chain/kinetics[30]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca3 /kinetics/chain/kinetics[30]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca2 /kinetics/chain/kinetics[30]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/Ca /kinetics/chain/kinetics[30]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca2 /kinetics/chain/kinetics[30]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca /kinetics/chain/kinetics[30]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/Ca /kinetics/chain/kinetics[30]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[30]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[30]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[29]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[30]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[30]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca /kinetics/chain/kinetics[30]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca /kinetics/chain/kinetics[30]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[30]/Ca REAC A B addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[30]/Ca REAC A B addmsg /kinetics/chain/kinetics[30]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[30]/Ca REAC A B addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[30]/Ca REAC A B addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[30]/Ca REAC A B addmsg /kinetics/chain/kinetics[30]/Ca_diff /kinetics/chain/kinetics[30]/Ca REAC B A addmsg /kinetics/chain/kinetics[29]/Ca/diff /kinetics/chain/kinetics[30]/Ca REAC B A addmsg /kinetics/chain/kinetics[30]/Ca/diff /kinetics/chain/kinetics[30]/Ca REAC A B addmsg /kinetics/chain/kinetics[30]/Ca /kinetics/chain/kinetics[30]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/Ca /kinetics/chain/kinetics[30]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/MAPK/craf-1 /kinetics/chain/kinetics[30]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[30]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[30]/Ras/GTP-Ras /kinetics/chain/kinetics[30]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PKM/trigger_PKM /kinetics/chain/kinetics[30]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[29]/PKM/Ca_detector/diff /kinetics/chain/kinetics[30]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[30]/PKM/Ca_detector/diff /kinetics/chain/kinetics[30]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[30]/PKM/Ca_detector /kinetics/chain/kinetics[30]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PKM/Ca_detector /kinetics/chain/kinetics[30]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[30]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[30]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[30]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[30]/PKM/turn_off_activator /kinetics/chain/kinetics[30]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[29]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[30]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[30]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[30]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[30]/PKM/PKM_synthesis /kinetics/chain/kinetics[30]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[30]/PKM/AA_pool /kinetics/chain/kinetics[30]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PKM/PKM_synthesis /kinetics/chain/kinetics[30]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PKM/PKM_synthesis /kinetics/chain/kinetics[30]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[30]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[30]/PKC/PKM-zeta /kinetics/chain/kinetics[30]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PKM/degraded_PKM /kinetics/chain/kinetics[30]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[30]/PKM/PKM_degradation /kinetics/chain/kinetics[30]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[30]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[30]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[30]/PKM/trigger_PKM /kinetics/chain/kinetics[30]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[29]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[30]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[30]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[30]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[30]/PKM/Ca.detector_complex /kinetics/chain/kinetics[30]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[30]/PKM/PKM_activator /kinetics/chain/kinetics[30]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PKM/Ca.detector_complex /kinetics/chain/kinetics[30]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PKM/Ca.detector_complex /kinetics/chain/kinetics[30]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[30]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[30]/PKM/turn_off_activator /kinetics/chain/kinetics[30]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[29]/PKM/PKM_activator/diff /kinetics/chain/kinetics[30]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[30]/PKM/PKM_activator/diff /kinetics/chain/kinetics[30]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[30]/PKM/PKM_activator /kinetics/chain/kinetics[30]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PKM/PKM_activator /kinetics/chain/kinetics[30]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/PKM/PKM_synthesis /kinetics/chain/kinetics[30]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PKM/PKM_activator /kinetics/chain/kinetics[30]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca4 /kinetics/chain/kinetics[30]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PKM/Ca_detector /kinetics/chain/kinetics[30]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[30]/PKM/Ca.detector_complex /kinetics/chain/kinetics[30]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[30]/Ca_diff /kinetics/chain/kinetics[30]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[30]/Ca /kinetics/chain/kinetics[30]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[30]/Ca_input /kinetics/chain/kinetics[30]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[31]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[31]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[31]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[31]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[31]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[30]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[31]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[31]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[31]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[31]/PKC/PKC-Ca /kinetics/chain/kinetics[31]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PKC/PKC-Ca /kinetics/chain/kinetics[31]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/PKC/PKC-Ca /kinetics/chain/kinetics[31]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[31]/PKC/PKC-cytosolic /kinetics/chain/kinetics[31]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/Ca /kinetics/chain/kinetics[31]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PKC/PKC-Ca /kinetics/chain/kinetics[31]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[31]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[31]/DAG /kinetics/chain/kinetics[31]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PKC/PKC-Ca /kinetics/chain/kinetics[31]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[31]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[31]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[31]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[31]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[31]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[31]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[30]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[31]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[31]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[31]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[31]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[31]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[31]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[31]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[30]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[31]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[31]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[31]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[31]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[31]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[31]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[31]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[31]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[31]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[30]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[31]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[31]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[31]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[31]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[31]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[31]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/PKC/PKC-DAG /kinetics/chain/kinetics[31]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[31]/PKC/PKC-cytosolic /kinetics/chain/kinetics[31]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/DAG /kinetics/chain/kinetics[31]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PKC/PKC-n-DAG /kinetics/chain/kinetics[31]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[30]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[31]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[31]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[31]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[31]/PKC/PKC-DAG /kinetics/chain/kinetics[31]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PKC/PKC-DAG /kinetics/chain/kinetics[31]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[31]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[31]/PKC/PKC-n-DAG /kinetics/chain/kinetics[31]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[30]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[31]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[31]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[31]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[31]/PKC/PKC-cytosolic /kinetics/chain/kinetics[31]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PKC/PKC-cytosolic /kinetics/chain/kinetics[31]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[31]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[31]/PKM/PKM_degradation /kinetics/chain/kinetics[31]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[30]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[31]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[31]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[31]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[31]/PKC/PKM-zeta /kinetics/chain/kinetics[31]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PKC/PKM-zeta /kinetics/chain/kinetics[31]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[31]/DAG REAC A B addmsg /kinetics/chain/kinetics[31]/PKC/PKC-n-DAG /kinetics/chain/kinetics[31]/DAG REAC A B addmsg /kinetics/chain/kinetics[31]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[31]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[31]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[31]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[31]/PKC/PKM-zeta /kinetics/chain/kinetics[31]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[31]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[31]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[31]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[31]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[31]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[31]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[31]/PKC-active /kinetics/chain/kinetics[31]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[31]/MAPK/craf-1 /kinetics/chain/kinetics[31]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PKC-active /kinetics/chain/kinetics[31]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[31]/Ras/GAP /kinetics/chain/kinetics[31]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PKC-active /kinetics/chain/kinetics[31]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[31]/Ras/inact-GEF /kinetics/chain/kinetics[31]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[31]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[31]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[31]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[31]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[31]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[30]/MAPK*/diff /kinetics/chain/kinetics[31]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[31]/MAPK*/diff /kinetics/chain/kinetics[31]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[31]/MAPK* /kinetics/chain/kinetics[31]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[31]/MAPK/craf-1* /kinetics/chain/kinetics[31]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/MAPK* /kinetics/chain/kinetics[31]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/MAPK* /kinetics/chain/kinetics[31]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[31]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[31]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[31]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[31]/Ras-act-unphosph-raf /kinetics/chain/kinetics[31]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[30]/MAPK/craf-1/diff /kinetics/chain/kinetics[31]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[31]/MAPK/craf-1/diff /kinetics/chain/kinetics[31]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[31]/MAPK/craf-1 /kinetics/chain/kinetics[31]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/MAPK/craf-1 /kinetics/chain/kinetics[31]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[31]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[31]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[31]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[31]/Ras-act-craf /kinetics/chain/kinetics[31]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[31]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[31]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[31]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[31]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[30]/MAPK/craf-1*/diff /kinetics/chain/kinetics[31]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[31]/MAPK/craf-1*/diff /kinetics/chain/kinetics[31]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[31]/MAPK/craf-1* /kinetics/chain/kinetics[31]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/MAPK/craf-1* /kinetics/chain/kinetics[31]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[31]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[31]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[31]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[31]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[30]/MAPK/MAPKK/diff /kinetics/chain/kinetics[31]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[31]/MAPK/MAPKK/diff /kinetics/chain/kinetics[31]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[31]/MAPK/MAPKK /kinetics/chain/kinetics[31]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/MAPK/MAPKK /kinetics/chain/kinetics[31]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[31]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[31]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[31]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[30]/MAPK/MAPK/diff /kinetics/chain/kinetics[31]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[31]/MAPK/MAPK/diff /kinetics/chain/kinetics[31]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[31]/MAPK/MAPK /kinetics/chain/kinetics[31]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/MAPK/MAPK /kinetics/chain/kinetics[31]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[31]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[31]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[31]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[30]/MAPK/craf-1**/diff /kinetics/chain/kinetics[31]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[31]/MAPK/craf-1**/diff /kinetics/chain/kinetics[31]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[31]/MAPK/craf-1** /kinetics/chain/kinetics[31]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/MAPK/craf-1** /kinetics/chain/kinetics[31]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[31]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[31]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[31]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[31]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[31]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[31]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[31]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[30]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[31]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[31]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[31]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[31]/MAPK/MAPK-tyr /kinetics/chain/kinetics[31]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/MAPK/MAPK-tyr /kinetics/chain/kinetics[31]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[31]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[31]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[31]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[31]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[31]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[31]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[31]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[30]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[31]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[31]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[31]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[31]/MAPK/MAPK /kinetics/chain/kinetics[31]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/MAPK/MAPKK* /kinetics/chain/kinetics[31]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[31]/MAPK/MAPK-tyr /kinetics/chain/kinetics[31]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/MAPK/MAPKK* /kinetics/chain/kinetics[31]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[31]/MAPK/MAPKK* /kinetics/chain/kinetics[31]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/MAPK/MAPKK* /kinetics/chain/kinetics[31]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[31]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[31]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[31]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[31]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[31]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[31]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[31]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[31]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[30]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[31]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[31]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[31]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[31]/MAPK/MAPKK-ser /kinetics/chain/kinetics[31]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/MAPK/MAPKK-ser /kinetics/chain/kinetics[31]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[31]/Ras-act-unphosph-raf /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[30]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[31]/MAPK/MAPKK /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[31]/MAPK/MAPKK-ser /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[31]/Ras-act-craf /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[30]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[31]/MAPK/MAPKK /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[31]/MAPK/MAPKK-ser /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[31]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[31]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[31]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[30]/MKP-1/diff /kinetics/chain/kinetics[31]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[31]/MKP-1/diff /kinetics/chain/kinetics[31]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[31]/MAPK/MAPK-tyr /kinetics/chain/kinetics[31]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/MKP-1 /kinetics/chain/kinetics[31]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[31]/MAPK* /kinetics/chain/kinetics[31]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/MKP-1 /kinetics/chain/kinetics[31]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[31]/MKP-1 /kinetics/chain/kinetics[31]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/MKP-1 /kinetics/chain/kinetics[31]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/MAPK/craf-1* /kinetics/chain/kinetics[31]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[31]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[31]/Ras/GTP-Ras /kinetics/chain/kinetics[31]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[31]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[31]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[31]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[31]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[31]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[31]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[31]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[30]/PPhosphatase2A/diff /kinetics/chain/kinetics[31]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[31]/PPhosphatase2A/diff /kinetics/chain/kinetics[31]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[31]/MAPK/craf-1* /kinetics/chain/kinetics[31]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PPhosphatase2A /kinetics/chain/kinetics[31]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[31]/MAPK/MAPKK* /kinetics/chain/kinetics[31]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PPhosphatase2A /kinetics/chain/kinetics[31]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[31]/MAPK/MAPKK-ser /kinetics/chain/kinetics[31]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PPhosphatase2A /kinetics/chain/kinetics[31]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[31]/MAPK/craf-1** /kinetics/chain/kinetics[31]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PPhosphatase2A /kinetics/chain/kinetics[31]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[31]/PPhosphatase2A /kinetics/chain/kinetics[31]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PPhosphatase2A /kinetics/chain/kinetics[31]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/Ras/inact-GEF /kinetics/chain/kinetics[31]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[31]/Ras/GEF* /kinetics/chain/kinetics[31]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[31]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[31]/Ras/dephosph-GEF /kinetics/chain/kinetics[31]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[31]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[31]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[31]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[31]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[30]/Ras/inact-GEF/diff /kinetics/chain/kinetics[31]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[31]/Ras/inact-GEF/diff /kinetics/chain/kinetics[31]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[31]/Ras/inact-GEF /kinetics/chain/kinetics[31]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[31]/Ras/GDP-Ras /kinetics/chain/kinetics[31]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/Ras/inact-GEF /kinetics/chain/kinetics[31]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/Ras/inact-GEF /kinetics/chain/kinetics[31]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[31]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[31]/Ras/dephosph-GEF /kinetics/chain/kinetics[31]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[31]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[31]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[30]/Ras/GEF*/diff /kinetics/chain/kinetics[31]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[31]/Ras/GEF*/diff /kinetics/chain/kinetics[31]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[31]/Ras/GEF* /kinetics/chain/kinetics[31]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[31]/Ras/GDP-Ras /kinetics/chain/kinetics[31]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/Ras/GEF* /kinetics/chain/kinetics[31]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/Ras/GEF* /kinetics/chain/kinetics[31]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/Ras-act-craf /kinetics/chain/kinetics[31]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[31]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[31]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[31]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[31]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[31]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[31]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[31]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[31]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[31]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[31]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[31]/Ras-act-unphosph-raf /kinetics/chain/kinetics[31]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[30]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[31]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[31]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[31]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[31]/Ras/GTP-Ras /kinetics/chain/kinetics[31]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/Ras/GTP-Ras /kinetics/chain/kinetics[31]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[31]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[31]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[31]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[31]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[31]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[31]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[31]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[31]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[31]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[30]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[31]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[31]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[31]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[31]/Ras/GDP-Ras /kinetics/chain/kinetics[31]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/Ras/GDP-Ras /kinetics/chain/kinetics[31]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/Ras/GTP-Ras /kinetics/chain/kinetics[31]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/Ras/GDP-Ras /kinetics/chain/kinetics[31]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[31]/Ras/GAP* /kinetics/chain/kinetics[31]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/Ras/GAP /kinetics/chain/kinetics[31]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[31]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[31]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[31]/Ras/dephosph-GAP /kinetics/chain/kinetics[31]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[30]/Ras/GAP*/diff /kinetics/chain/kinetics[31]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[31]/Ras/GAP*/diff /kinetics/chain/kinetics[31]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[31]/Ras/GAP* /kinetics/chain/kinetics[31]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/Ras/GAP* /kinetics/chain/kinetics[31]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[31]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[31]/Ras/dephosph-GAP /kinetics/chain/kinetics[31]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[31]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[31]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[30]/Ras/GAP/diff /kinetics/chain/kinetics[31]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[31]/Ras/GAP/diff /kinetics/chain/kinetics[31]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[31]/Ras/GTP-Ras /kinetics/chain/kinetics[31]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/Ras/GAP /kinetics/chain/kinetics[31]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[31]/Ras/GAP /kinetics/chain/kinetics[31]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/Ras/GAP /kinetics/chain/kinetics[31]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/Ras/inact-GEF /kinetics/chain/kinetics[31]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/Ras/CaM-GEF /kinetics/chain/kinetics[31]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca4 /kinetics/chain/kinetics[31]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[31]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[31]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[31]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[30]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[31]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[31]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[31]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[31]/Ras/GDP-Ras /kinetics/chain/kinetics[31]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/Ras/CaM-GEF /kinetics/chain/kinetics[31]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[31]/Ras/CaM-GEF /kinetics/chain/kinetics[31]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/Ras/CaM-GEF /kinetics/chain/kinetics[31]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[31]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[30]/CaM/CaM/diff /kinetics/chain/kinetics[31]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[31]/CaM/CaM/diff /kinetics/chain/kinetics[31]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[31]/CaM/CaM /kinetics/chain/kinetics[31]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/CaM/CaM /kinetics/chain/kinetics[31]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca3 /kinetics/chain/kinetics[31]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca4 /kinetics/chain/kinetics[31]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[31]/Ca /kinetics/chain/kinetics[31]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[31]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[31]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[31]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[31]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca3 /kinetics/chain/kinetics[31]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca3 /kinetics/chain/kinetics[31]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[31]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[31]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[31]/PKM/trigger_PKM /kinetics/chain/kinetics[31]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[31]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[31]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca4 /kinetics/chain/kinetics[31]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca4 /kinetics/chain/kinetics[31]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/CaM/CaM /kinetics/chain/kinetics[31]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca /kinetics/chain/kinetics[31]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[31]/Ca /kinetics/chain/kinetics[31]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[31]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[31]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[31]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[31]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca2 /kinetics/chain/kinetics[31]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca2 /kinetics/chain/kinetics[31]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca3 /kinetics/chain/kinetics[31]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca2 /kinetics/chain/kinetics[31]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/Ca /kinetics/chain/kinetics[31]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca2 /kinetics/chain/kinetics[31]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca /kinetics/chain/kinetics[31]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/Ca /kinetics/chain/kinetics[31]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[31]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[31]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[30]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[31]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[31]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca /kinetics/chain/kinetics[31]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca /kinetics/chain/kinetics[31]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[31]/Ca REAC A B addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[31]/Ca REAC A B addmsg /kinetics/chain/kinetics[31]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[31]/Ca REAC A B addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[31]/Ca REAC A B addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[31]/Ca REAC A B addmsg /kinetics/chain/kinetics[31]/Ca_diff /kinetics/chain/kinetics[31]/Ca REAC B A addmsg /kinetics/chain/kinetics[30]/Ca/diff /kinetics/chain/kinetics[31]/Ca REAC B A addmsg /kinetics/chain/kinetics[31]/Ca/diff /kinetics/chain/kinetics[31]/Ca REAC A B addmsg /kinetics/chain/kinetics[31]/Ca /kinetics/chain/kinetics[31]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/Ca /kinetics/chain/kinetics[31]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/MAPK/craf-1 /kinetics/chain/kinetics[31]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[31]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[31]/Ras/GTP-Ras /kinetics/chain/kinetics[31]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PKM/trigger_PKM /kinetics/chain/kinetics[31]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[30]/PKM/Ca_detector/diff /kinetics/chain/kinetics[31]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[31]/PKM/Ca_detector/diff /kinetics/chain/kinetics[31]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[31]/PKM/Ca_detector /kinetics/chain/kinetics[31]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PKM/Ca_detector /kinetics/chain/kinetics[31]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[31]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[31]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[31]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[31]/PKM/turn_off_activator /kinetics/chain/kinetics[31]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[30]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[31]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[31]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[31]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[31]/PKM/PKM_synthesis /kinetics/chain/kinetics[31]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[31]/PKM/AA_pool /kinetics/chain/kinetics[31]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PKM/PKM_synthesis /kinetics/chain/kinetics[31]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PKM/PKM_synthesis /kinetics/chain/kinetics[31]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[31]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[31]/PKC/PKM-zeta /kinetics/chain/kinetics[31]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PKM/degraded_PKM /kinetics/chain/kinetics[31]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[31]/PKM/PKM_degradation /kinetics/chain/kinetics[31]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[31]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[31]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[31]/PKM/trigger_PKM /kinetics/chain/kinetics[31]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[30]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[31]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[31]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[31]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[31]/PKM/Ca.detector_complex /kinetics/chain/kinetics[31]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[31]/PKM/PKM_activator /kinetics/chain/kinetics[31]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PKM/Ca.detector_complex /kinetics/chain/kinetics[31]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PKM/Ca.detector_complex /kinetics/chain/kinetics[31]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[31]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[31]/PKM/turn_off_activator /kinetics/chain/kinetics[31]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[30]/PKM/PKM_activator/diff /kinetics/chain/kinetics[31]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[31]/PKM/PKM_activator/diff /kinetics/chain/kinetics[31]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[31]/PKM/PKM_activator /kinetics/chain/kinetics[31]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PKM/PKM_activator /kinetics/chain/kinetics[31]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/PKM/PKM_synthesis /kinetics/chain/kinetics[31]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PKM/PKM_activator /kinetics/chain/kinetics[31]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca4 /kinetics/chain/kinetics[31]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PKM/Ca_detector /kinetics/chain/kinetics[31]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[31]/PKM/Ca.detector_complex /kinetics/chain/kinetics[31]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[31]/Ca_diff /kinetics/chain/kinetics[31]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[31]/Ca /kinetics/chain/kinetics[31]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[31]/Ca_input /kinetics/chain/kinetics[31]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[32]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[32]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[32]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[32]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[32]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[31]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[32]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[32]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[32]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[32]/PKC/PKC-Ca /kinetics/chain/kinetics[32]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PKC/PKC-Ca /kinetics/chain/kinetics[32]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/PKC/PKC-Ca /kinetics/chain/kinetics[32]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[32]/PKC/PKC-cytosolic /kinetics/chain/kinetics[32]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/Ca /kinetics/chain/kinetics[32]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PKC/PKC-Ca /kinetics/chain/kinetics[32]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[32]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[32]/DAG /kinetics/chain/kinetics[32]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PKC/PKC-Ca /kinetics/chain/kinetics[32]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[32]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[32]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[32]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[32]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[32]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[32]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[31]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[32]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[32]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[32]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[32]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[32]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[32]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[32]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[31]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[32]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[32]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[32]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[32]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[32]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[32]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[32]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[32]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[32]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[31]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[32]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[32]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[32]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[32]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[32]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[32]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/PKC/PKC-DAG /kinetics/chain/kinetics[32]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[32]/PKC/PKC-cytosolic /kinetics/chain/kinetics[32]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/DAG /kinetics/chain/kinetics[32]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PKC/PKC-n-DAG /kinetics/chain/kinetics[32]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[31]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[32]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[32]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[32]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[32]/PKC/PKC-DAG /kinetics/chain/kinetics[32]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PKC/PKC-DAG /kinetics/chain/kinetics[32]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[32]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[32]/PKC/PKC-n-DAG /kinetics/chain/kinetics[32]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[31]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[32]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[32]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[32]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[32]/PKC/PKC-cytosolic /kinetics/chain/kinetics[32]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PKC/PKC-cytosolic /kinetics/chain/kinetics[32]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[32]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[32]/PKM/PKM_degradation /kinetics/chain/kinetics[32]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[31]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[32]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[32]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[32]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[32]/PKC/PKM-zeta /kinetics/chain/kinetics[32]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PKC/PKM-zeta /kinetics/chain/kinetics[32]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[32]/DAG REAC A B addmsg /kinetics/chain/kinetics[32]/PKC/PKC-n-DAG /kinetics/chain/kinetics[32]/DAG REAC A B addmsg /kinetics/chain/kinetics[32]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[32]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[32]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[32]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[32]/PKC/PKM-zeta /kinetics/chain/kinetics[32]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[32]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[32]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[32]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[32]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[32]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[32]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[32]/PKC-active /kinetics/chain/kinetics[32]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[32]/MAPK/craf-1 /kinetics/chain/kinetics[32]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PKC-active /kinetics/chain/kinetics[32]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[32]/Ras/GAP /kinetics/chain/kinetics[32]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PKC-active /kinetics/chain/kinetics[32]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[32]/Ras/inact-GEF /kinetics/chain/kinetics[32]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[32]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[32]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[32]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[32]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[32]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[31]/MAPK*/diff /kinetics/chain/kinetics[32]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[32]/MAPK*/diff /kinetics/chain/kinetics[32]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[32]/MAPK* /kinetics/chain/kinetics[32]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[32]/MAPK/craf-1* /kinetics/chain/kinetics[32]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/MAPK* /kinetics/chain/kinetics[32]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/MAPK* /kinetics/chain/kinetics[32]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[32]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[32]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[32]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[32]/Ras-act-unphosph-raf /kinetics/chain/kinetics[32]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[31]/MAPK/craf-1/diff /kinetics/chain/kinetics[32]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[32]/MAPK/craf-1/diff /kinetics/chain/kinetics[32]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[32]/MAPK/craf-1 /kinetics/chain/kinetics[32]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/MAPK/craf-1 /kinetics/chain/kinetics[32]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[32]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[32]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[32]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[32]/Ras-act-craf /kinetics/chain/kinetics[32]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[32]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[32]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[32]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[32]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[31]/MAPK/craf-1*/diff /kinetics/chain/kinetics[32]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[32]/MAPK/craf-1*/diff /kinetics/chain/kinetics[32]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[32]/MAPK/craf-1* /kinetics/chain/kinetics[32]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/MAPK/craf-1* /kinetics/chain/kinetics[32]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[32]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[32]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[32]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[32]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[31]/MAPK/MAPKK/diff /kinetics/chain/kinetics[32]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[32]/MAPK/MAPKK/diff /kinetics/chain/kinetics[32]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[32]/MAPK/MAPKK /kinetics/chain/kinetics[32]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/MAPK/MAPKK /kinetics/chain/kinetics[32]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[32]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[32]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[32]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[31]/MAPK/MAPK/diff /kinetics/chain/kinetics[32]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[32]/MAPK/MAPK/diff /kinetics/chain/kinetics[32]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[32]/MAPK/MAPK /kinetics/chain/kinetics[32]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/MAPK/MAPK /kinetics/chain/kinetics[32]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[32]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[32]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[32]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[31]/MAPK/craf-1**/diff /kinetics/chain/kinetics[32]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[32]/MAPK/craf-1**/diff /kinetics/chain/kinetics[32]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[32]/MAPK/craf-1** /kinetics/chain/kinetics[32]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/MAPK/craf-1** /kinetics/chain/kinetics[32]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[32]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[32]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[32]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[32]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[32]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[32]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[32]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[31]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[32]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[32]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[32]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[32]/MAPK/MAPK-tyr /kinetics/chain/kinetics[32]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/MAPK/MAPK-tyr /kinetics/chain/kinetics[32]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[32]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[32]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[32]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[32]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[32]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[32]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[32]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[31]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[32]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[32]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[32]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[32]/MAPK/MAPK /kinetics/chain/kinetics[32]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/MAPK/MAPKK* /kinetics/chain/kinetics[32]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[32]/MAPK/MAPK-tyr /kinetics/chain/kinetics[32]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/MAPK/MAPKK* /kinetics/chain/kinetics[32]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[32]/MAPK/MAPKK* /kinetics/chain/kinetics[32]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/MAPK/MAPKK* /kinetics/chain/kinetics[32]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[32]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[32]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[32]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[32]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[32]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[32]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[32]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[32]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[31]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[32]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[32]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[32]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[32]/MAPK/MAPKK-ser /kinetics/chain/kinetics[32]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/MAPK/MAPKK-ser /kinetics/chain/kinetics[32]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[32]/Ras-act-unphosph-raf /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[32]/MAPK/MAPKK /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[32]/MAPK/MAPKK-ser /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[32]/Ras-act-craf /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[32]/MAPK/MAPKK /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[32]/MAPK/MAPKK-ser /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[32]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[32]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[32]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[31]/MKP-1/diff /kinetics/chain/kinetics[32]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[32]/MKP-1/diff /kinetics/chain/kinetics[32]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[32]/MAPK/MAPK-tyr /kinetics/chain/kinetics[32]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/MKP-1 /kinetics/chain/kinetics[32]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[32]/MAPK* /kinetics/chain/kinetics[32]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/MKP-1 /kinetics/chain/kinetics[32]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[32]/MKP-1 /kinetics/chain/kinetics[32]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/MKP-1 /kinetics/chain/kinetics[32]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/MAPK/craf-1* /kinetics/chain/kinetics[32]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[32]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[32]/Ras/GTP-Ras /kinetics/chain/kinetics[32]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[32]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[32]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[32]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[32]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[32]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[32]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[32]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[31]/PPhosphatase2A/diff /kinetics/chain/kinetics[32]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[32]/PPhosphatase2A/diff /kinetics/chain/kinetics[32]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[32]/MAPK/craf-1* /kinetics/chain/kinetics[32]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PPhosphatase2A /kinetics/chain/kinetics[32]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[32]/MAPK/MAPKK* /kinetics/chain/kinetics[32]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PPhosphatase2A /kinetics/chain/kinetics[32]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[32]/MAPK/MAPKK-ser /kinetics/chain/kinetics[32]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PPhosphatase2A /kinetics/chain/kinetics[32]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[32]/MAPK/craf-1** /kinetics/chain/kinetics[32]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PPhosphatase2A /kinetics/chain/kinetics[32]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[32]/PPhosphatase2A /kinetics/chain/kinetics[32]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PPhosphatase2A /kinetics/chain/kinetics[32]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/Ras/inact-GEF /kinetics/chain/kinetics[32]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[32]/Ras/GEF* /kinetics/chain/kinetics[32]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[32]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[32]/Ras/dephosph-GEF /kinetics/chain/kinetics[32]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[32]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[32]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[32]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[32]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[31]/Ras/inact-GEF/diff /kinetics/chain/kinetics[32]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[32]/Ras/inact-GEF/diff /kinetics/chain/kinetics[32]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[32]/Ras/inact-GEF /kinetics/chain/kinetics[32]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[32]/Ras/GDP-Ras /kinetics/chain/kinetics[32]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/Ras/inact-GEF /kinetics/chain/kinetics[32]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/Ras/inact-GEF /kinetics/chain/kinetics[32]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[32]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[32]/Ras/dephosph-GEF /kinetics/chain/kinetics[32]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[32]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[32]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[31]/Ras/GEF*/diff /kinetics/chain/kinetics[32]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[32]/Ras/GEF*/diff /kinetics/chain/kinetics[32]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[32]/Ras/GEF* /kinetics/chain/kinetics[32]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[32]/Ras/GDP-Ras /kinetics/chain/kinetics[32]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/Ras/GEF* /kinetics/chain/kinetics[32]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/Ras/GEF* /kinetics/chain/kinetics[32]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/Ras-act-craf /kinetics/chain/kinetics[32]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[32]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[32]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[32]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[32]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[32]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[32]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[32]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[32]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[32]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[32]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[32]/Ras-act-unphosph-raf /kinetics/chain/kinetics[32]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[31]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[32]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[32]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[32]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[32]/Ras/GTP-Ras /kinetics/chain/kinetics[32]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/Ras/GTP-Ras /kinetics/chain/kinetics[32]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[32]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[32]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[32]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[32]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[32]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[32]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[32]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[32]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[32]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[31]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[32]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[32]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[32]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[32]/Ras/GDP-Ras /kinetics/chain/kinetics[32]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/Ras/GDP-Ras /kinetics/chain/kinetics[32]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/Ras/GTP-Ras /kinetics/chain/kinetics[32]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/Ras/GDP-Ras /kinetics/chain/kinetics[32]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[32]/Ras/GAP* /kinetics/chain/kinetics[32]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/Ras/GAP /kinetics/chain/kinetics[32]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[32]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[32]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[32]/Ras/dephosph-GAP /kinetics/chain/kinetics[32]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[31]/Ras/GAP*/diff /kinetics/chain/kinetics[32]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[32]/Ras/GAP*/diff /kinetics/chain/kinetics[32]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[32]/Ras/GAP* /kinetics/chain/kinetics[32]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/Ras/GAP* /kinetics/chain/kinetics[32]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[32]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[32]/Ras/dephosph-GAP /kinetics/chain/kinetics[32]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[32]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[32]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[31]/Ras/GAP/diff /kinetics/chain/kinetics[32]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[32]/Ras/GAP/diff /kinetics/chain/kinetics[32]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[32]/Ras/GTP-Ras /kinetics/chain/kinetics[32]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/Ras/GAP /kinetics/chain/kinetics[32]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[32]/Ras/GAP /kinetics/chain/kinetics[32]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/Ras/GAP /kinetics/chain/kinetics[32]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/Ras/inact-GEF /kinetics/chain/kinetics[32]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/Ras/CaM-GEF /kinetics/chain/kinetics[32]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca4 /kinetics/chain/kinetics[32]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[32]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[32]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[32]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[31]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[32]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[32]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[32]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[32]/Ras/GDP-Ras /kinetics/chain/kinetics[32]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/Ras/CaM-GEF /kinetics/chain/kinetics[32]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[32]/Ras/CaM-GEF /kinetics/chain/kinetics[32]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/Ras/CaM-GEF /kinetics/chain/kinetics[32]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[32]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[31]/CaM/CaM/diff /kinetics/chain/kinetics[32]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[32]/CaM/CaM/diff /kinetics/chain/kinetics[32]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[32]/CaM/CaM /kinetics/chain/kinetics[32]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/CaM/CaM /kinetics/chain/kinetics[32]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca3 /kinetics/chain/kinetics[32]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca4 /kinetics/chain/kinetics[32]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[32]/Ca /kinetics/chain/kinetics[32]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[32]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[32]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[32]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[32]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca3 /kinetics/chain/kinetics[32]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca3 /kinetics/chain/kinetics[32]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[32]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[32]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[32]/PKM/trigger_PKM /kinetics/chain/kinetics[32]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[32]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[32]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca4 /kinetics/chain/kinetics[32]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca4 /kinetics/chain/kinetics[32]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/CaM/CaM /kinetics/chain/kinetics[32]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca /kinetics/chain/kinetics[32]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[32]/Ca /kinetics/chain/kinetics[32]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[32]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[32]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[32]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[32]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca2 /kinetics/chain/kinetics[32]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca2 /kinetics/chain/kinetics[32]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca3 /kinetics/chain/kinetics[32]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca2 /kinetics/chain/kinetics[32]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/Ca /kinetics/chain/kinetics[32]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca2 /kinetics/chain/kinetics[32]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca /kinetics/chain/kinetics[32]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/Ca /kinetics/chain/kinetics[32]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[32]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[32]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[31]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[32]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[32]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca /kinetics/chain/kinetics[32]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca /kinetics/chain/kinetics[32]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[32]/Ca REAC A B addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[32]/Ca REAC A B addmsg /kinetics/chain/kinetics[32]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[32]/Ca REAC A B addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[32]/Ca REAC A B addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[32]/Ca REAC A B addmsg /kinetics/chain/kinetics[32]/Ca_diff /kinetics/chain/kinetics[32]/Ca REAC B A addmsg /kinetics/chain/kinetics[31]/Ca/diff /kinetics/chain/kinetics[32]/Ca REAC B A addmsg /kinetics/chain/kinetics[32]/Ca/diff /kinetics/chain/kinetics[32]/Ca REAC A B addmsg /kinetics/chain/kinetics[32]/Ca /kinetics/chain/kinetics[32]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/Ca /kinetics/chain/kinetics[32]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/MAPK/craf-1 /kinetics/chain/kinetics[32]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[32]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[32]/Ras/GTP-Ras /kinetics/chain/kinetics[32]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PKM/trigger_PKM /kinetics/chain/kinetics[32]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[31]/PKM/Ca_detector/diff /kinetics/chain/kinetics[32]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[32]/PKM/Ca_detector/diff /kinetics/chain/kinetics[32]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[32]/PKM/Ca_detector /kinetics/chain/kinetics[32]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PKM/Ca_detector /kinetics/chain/kinetics[32]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[32]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[32]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[32]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[32]/PKM/turn_off_activator /kinetics/chain/kinetics[32]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[31]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[32]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[32]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[32]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[32]/PKM/PKM_synthesis /kinetics/chain/kinetics[32]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[32]/PKM/AA_pool /kinetics/chain/kinetics[32]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PKM/PKM_synthesis /kinetics/chain/kinetics[32]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PKM/PKM_synthesis /kinetics/chain/kinetics[32]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[32]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[32]/PKC/PKM-zeta /kinetics/chain/kinetics[32]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PKM/degraded_PKM /kinetics/chain/kinetics[32]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[32]/PKM/PKM_degradation /kinetics/chain/kinetics[32]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[32]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[32]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[32]/PKM/trigger_PKM /kinetics/chain/kinetics[32]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[31]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[32]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[32]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[32]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[32]/PKM/Ca.detector_complex /kinetics/chain/kinetics[32]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[32]/PKM/PKM_activator /kinetics/chain/kinetics[32]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PKM/Ca.detector_complex /kinetics/chain/kinetics[32]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PKM/Ca.detector_complex /kinetics/chain/kinetics[32]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[32]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[32]/PKM/turn_off_activator /kinetics/chain/kinetics[32]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[31]/PKM/PKM_activator/diff /kinetics/chain/kinetics[32]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[32]/PKM/PKM_activator/diff /kinetics/chain/kinetics[32]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[32]/PKM/PKM_activator /kinetics/chain/kinetics[32]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PKM/PKM_activator /kinetics/chain/kinetics[32]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/PKM/PKM_synthesis /kinetics/chain/kinetics[32]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PKM/PKM_activator /kinetics/chain/kinetics[32]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca4 /kinetics/chain/kinetics[32]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PKM/Ca_detector /kinetics/chain/kinetics[32]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[32]/PKM/Ca.detector_complex /kinetics/chain/kinetics[32]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[32]/Ca_diff /kinetics/chain/kinetics[32]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[32]/Ca /kinetics/chain/kinetics[32]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[32]/Ca_input /kinetics/chain/kinetics[32]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[33]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[33]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[33]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[33]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[33]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[32]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[33]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[33]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[33]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[33]/PKC/PKC-Ca /kinetics/chain/kinetics[33]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PKC/PKC-Ca /kinetics/chain/kinetics[33]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/PKC/PKC-Ca /kinetics/chain/kinetics[33]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[33]/PKC/PKC-cytosolic /kinetics/chain/kinetics[33]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/Ca /kinetics/chain/kinetics[33]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PKC/PKC-Ca /kinetics/chain/kinetics[33]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[33]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[33]/DAG /kinetics/chain/kinetics[33]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PKC/PKC-Ca /kinetics/chain/kinetics[33]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[33]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[33]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[33]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[33]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[33]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[33]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[32]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[33]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[33]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[33]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[33]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[33]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[33]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[33]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[32]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[33]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[33]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[33]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[33]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[33]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[33]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[33]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[33]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[33]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[32]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[33]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[33]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[33]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[33]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[33]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[33]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/PKC/PKC-DAG /kinetics/chain/kinetics[33]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[33]/PKC/PKC-cytosolic /kinetics/chain/kinetics[33]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/DAG /kinetics/chain/kinetics[33]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PKC/PKC-n-DAG /kinetics/chain/kinetics[33]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[32]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[33]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[33]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[33]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[33]/PKC/PKC-DAG /kinetics/chain/kinetics[33]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PKC/PKC-DAG /kinetics/chain/kinetics[33]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[33]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[33]/PKC/PKC-n-DAG /kinetics/chain/kinetics[33]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[32]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[33]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[33]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[33]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[33]/PKC/PKC-cytosolic /kinetics/chain/kinetics[33]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PKC/PKC-cytosolic /kinetics/chain/kinetics[33]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[33]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[33]/PKM/PKM_degradation /kinetics/chain/kinetics[33]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[32]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[33]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[33]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[33]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[33]/PKC/PKM-zeta /kinetics/chain/kinetics[33]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PKC/PKM-zeta /kinetics/chain/kinetics[33]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[33]/DAG REAC A B addmsg /kinetics/chain/kinetics[33]/PKC/PKC-n-DAG /kinetics/chain/kinetics[33]/DAG REAC A B addmsg /kinetics/chain/kinetics[33]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[33]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[33]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[33]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[33]/PKC/PKM-zeta /kinetics/chain/kinetics[33]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[33]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[33]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[33]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[33]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[33]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[33]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[33]/PKC-active /kinetics/chain/kinetics[33]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[33]/MAPK/craf-1 /kinetics/chain/kinetics[33]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PKC-active /kinetics/chain/kinetics[33]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[33]/Ras/GAP /kinetics/chain/kinetics[33]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PKC-active /kinetics/chain/kinetics[33]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[33]/Ras/inact-GEF /kinetics/chain/kinetics[33]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[33]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[33]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[33]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[33]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[33]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[32]/MAPK*/diff /kinetics/chain/kinetics[33]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[33]/MAPK*/diff /kinetics/chain/kinetics[33]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[33]/MAPK* /kinetics/chain/kinetics[33]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[33]/MAPK/craf-1* /kinetics/chain/kinetics[33]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/MAPK* /kinetics/chain/kinetics[33]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/MAPK* /kinetics/chain/kinetics[33]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[33]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[33]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[33]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[33]/Ras-act-unphosph-raf /kinetics/chain/kinetics[33]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[32]/MAPK/craf-1/diff /kinetics/chain/kinetics[33]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[33]/MAPK/craf-1/diff /kinetics/chain/kinetics[33]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[33]/MAPK/craf-1 /kinetics/chain/kinetics[33]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/MAPK/craf-1 /kinetics/chain/kinetics[33]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[33]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[33]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[33]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[33]/Ras-act-craf /kinetics/chain/kinetics[33]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[33]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[33]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[33]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[33]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[32]/MAPK/craf-1*/diff /kinetics/chain/kinetics[33]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[33]/MAPK/craf-1*/diff /kinetics/chain/kinetics[33]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[33]/MAPK/craf-1* /kinetics/chain/kinetics[33]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/MAPK/craf-1* /kinetics/chain/kinetics[33]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[33]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[33]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[33]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[33]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[33]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[32]/MAPK/MAPKK/diff /kinetics/chain/kinetics[33]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[33]/MAPK/MAPKK/diff /kinetics/chain/kinetics[33]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[33]/MAPK/MAPKK /kinetics/chain/kinetics[33]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/MAPK/MAPKK /kinetics/chain/kinetics[33]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[33]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[33]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[33]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[32]/MAPK/MAPK/diff /kinetics/chain/kinetics[33]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[33]/MAPK/MAPK/diff /kinetics/chain/kinetics[33]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[33]/MAPK/MAPK /kinetics/chain/kinetics[33]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/MAPK/MAPK /kinetics/chain/kinetics[33]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[33]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[33]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[33]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[32]/MAPK/craf-1**/diff /kinetics/chain/kinetics[33]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[33]/MAPK/craf-1**/diff /kinetics/chain/kinetics[33]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[33]/MAPK/craf-1** /kinetics/chain/kinetics[33]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/MAPK/craf-1** /kinetics/chain/kinetics[33]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[33]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[33]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[33]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[33]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[33]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[33]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[33]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[32]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[33]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[33]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[33]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[33]/MAPK/MAPK-tyr /kinetics/chain/kinetics[33]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/MAPK/MAPK-tyr /kinetics/chain/kinetics[33]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[33]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[33]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[33]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[33]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[33]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[33]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[33]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[33]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[33]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[32]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[33]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[33]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[33]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[33]/MAPK/MAPK /kinetics/chain/kinetics[33]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/MAPK/MAPKK* /kinetics/chain/kinetics[33]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[33]/MAPK/MAPK-tyr /kinetics/chain/kinetics[33]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/MAPK/MAPKK* /kinetics/chain/kinetics[33]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[33]/MAPK/MAPKK* /kinetics/chain/kinetics[33]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/MAPK/MAPKK* /kinetics/chain/kinetics[33]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[33]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[33]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[33]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[33]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[33]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[33]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[33]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[33]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[33]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[33]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[33]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[32]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[33]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[33]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[33]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[33]/MAPK/MAPKK-ser /kinetics/chain/kinetics[33]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/MAPK/MAPKK-ser /kinetics/chain/kinetics[33]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[33]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[33]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[33]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[33]/Ras-act-unphosph-raf /kinetics/chain/kinetics[33]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[33]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[33]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[33]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[33]/MAPK/MAPKK /kinetics/chain/kinetics[33]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[33]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[33]/MAPK/MAPKK-ser /kinetics/chain/kinetics[33]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[33]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[33]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[33]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[33]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[33]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[33]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[33]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[33]/Ras-act-craf /kinetics/chain/kinetics[33]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[33]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[33]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[33]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[33]/MAPK/MAPKK /kinetics/chain/kinetics[33]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[33]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[33]/MAPK/MAPKK-ser /kinetics/chain/kinetics[33]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[33]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[33]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[33]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[33]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[33]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[33]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[33]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[32]/MKP-1/diff /kinetics/chain/kinetics[33]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[33]/MKP-1/diff /kinetics/chain/kinetics[33]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[33]/MAPK/MAPK-tyr /kinetics/chain/kinetics[33]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/MKP-1 /kinetics/chain/kinetics[33]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[33]/MAPK* /kinetics/chain/kinetics[33]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/MKP-1 /kinetics/chain/kinetics[33]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[33]/MKP-1 /kinetics/chain/kinetics[33]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/MKP-1 /kinetics/chain/kinetics[33]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/MAPK/craf-1* /kinetics/chain/kinetics[33]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[33]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[33]/Ras/GTP-Ras /kinetics/chain/kinetics[33]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[33]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[33]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[33]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[33]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[33]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[33]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[33]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[32]/PPhosphatase2A/diff /kinetics/chain/kinetics[33]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[33]/PPhosphatase2A/diff /kinetics/chain/kinetics[33]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[33]/MAPK/craf-1* /kinetics/chain/kinetics[33]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PPhosphatase2A /kinetics/chain/kinetics[33]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[33]/MAPK/MAPKK* /kinetics/chain/kinetics[33]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PPhosphatase2A /kinetics/chain/kinetics[33]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[33]/MAPK/MAPKK-ser /kinetics/chain/kinetics[33]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PPhosphatase2A /kinetics/chain/kinetics[33]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[33]/MAPK/craf-1** /kinetics/chain/kinetics[33]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PPhosphatase2A /kinetics/chain/kinetics[33]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[33]/PPhosphatase2A /kinetics/chain/kinetics[33]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PPhosphatase2A /kinetics/chain/kinetics[33]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/Ras/inact-GEF /kinetics/chain/kinetics[33]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[33]/Ras/GEF* /kinetics/chain/kinetics[33]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[33]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[33]/Ras/dephosph-GEF /kinetics/chain/kinetics[33]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[33]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[33]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[33]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[33]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[32]/Ras/inact-GEF/diff /kinetics/chain/kinetics[33]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[33]/Ras/inact-GEF/diff /kinetics/chain/kinetics[33]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[33]/Ras/inact-GEF /kinetics/chain/kinetics[33]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[33]/Ras/GDP-Ras /kinetics/chain/kinetics[33]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/Ras/inact-GEF /kinetics/chain/kinetics[33]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/Ras/inact-GEF /kinetics/chain/kinetics[33]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[33]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[33]/Ras/dephosph-GEF /kinetics/chain/kinetics[33]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[33]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[33]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[32]/Ras/GEF*/diff /kinetics/chain/kinetics[33]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[33]/Ras/GEF*/diff /kinetics/chain/kinetics[33]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[33]/Ras/GEF* /kinetics/chain/kinetics[33]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[33]/Ras/GDP-Ras /kinetics/chain/kinetics[33]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/Ras/GEF* /kinetics/chain/kinetics[33]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/Ras/GEF* /kinetics/chain/kinetics[33]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/Ras-act-craf /kinetics/chain/kinetics[33]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[33]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[33]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[33]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[33]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[33]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[33]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[33]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[33]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[33]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[33]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[33]/Ras-act-unphosph-raf /kinetics/chain/kinetics[33]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[32]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[33]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[33]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[33]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[33]/Ras/GTP-Ras /kinetics/chain/kinetics[33]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/Ras/GTP-Ras /kinetics/chain/kinetics[33]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[33]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[33]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[33]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[33]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[33]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[33]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[33]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[33]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[33]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[32]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[33]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[33]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[33]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[33]/Ras/GDP-Ras /kinetics/chain/kinetics[33]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/Ras/GDP-Ras /kinetics/chain/kinetics[33]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/Ras/GTP-Ras /kinetics/chain/kinetics[33]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/Ras/GDP-Ras /kinetics/chain/kinetics[33]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[33]/Ras/GAP* /kinetics/chain/kinetics[33]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/Ras/GAP /kinetics/chain/kinetics[33]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[33]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[33]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[33]/Ras/dephosph-GAP /kinetics/chain/kinetics[33]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[32]/Ras/GAP*/diff /kinetics/chain/kinetics[33]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[33]/Ras/GAP*/diff /kinetics/chain/kinetics[33]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[33]/Ras/GAP* /kinetics/chain/kinetics[33]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/Ras/GAP* /kinetics/chain/kinetics[33]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[33]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[33]/Ras/dephosph-GAP /kinetics/chain/kinetics[33]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[33]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[33]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[32]/Ras/GAP/diff /kinetics/chain/kinetics[33]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[33]/Ras/GAP/diff /kinetics/chain/kinetics[33]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[33]/Ras/GTP-Ras /kinetics/chain/kinetics[33]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/Ras/GAP /kinetics/chain/kinetics[33]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[33]/Ras/GAP /kinetics/chain/kinetics[33]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/Ras/GAP /kinetics/chain/kinetics[33]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/Ras/inact-GEF /kinetics/chain/kinetics[33]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/Ras/CaM-GEF /kinetics/chain/kinetics[33]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca4 /kinetics/chain/kinetics[33]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[33]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[33]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[33]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[32]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[33]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[33]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[33]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[33]/Ras/GDP-Ras /kinetics/chain/kinetics[33]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/Ras/CaM-GEF /kinetics/chain/kinetics[33]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[33]/Ras/CaM-GEF /kinetics/chain/kinetics[33]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/Ras/CaM-GEF /kinetics/chain/kinetics[33]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[33]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[32]/CaM/CaM/diff /kinetics/chain/kinetics[33]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[33]/CaM/CaM/diff /kinetics/chain/kinetics[33]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[33]/CaM/CaM /kinetics/chain/kinetics[33]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/CaM/CaM /kinetics/chain/kinetics[33]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca3 /kinetics/chain/kinetics[33]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca4 /kinetics/chain/kinetics[33]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[33]/Ca /kinetics/chain/kinetics[33]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[33]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[33]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[33]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[33]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca3 /kinetics/chain/kinetics[33]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca3 /kinetics/chain/kinetics[33]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[33]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[33]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[33]/PKM/trigger_PKM /kinetics/chain/kinetics[33]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[33]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[33]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca4 /kinetics/chain/kinetics[33]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca4 /kinetics/chain/kinetics[33]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/CaM/CaM /kinetics/chain/kinetics[33]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca /kinetics/chain/kinetics[33]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[33]/Ca /kinetics/chain/kinetics[33]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[33]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[33]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[33]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[33]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca2 /kinetics/chain/kinetics[33]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca2 /kinetics/chain/kinetics[33]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca3 /kinetics/chain/kinetics[33]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca2 /kinetics/chain/kinetics[33]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/Ca /kinetics/chain/kinetics[33]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca2 /kinetics/chain/kinetics[33]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca /kinetics/chain/kinetics[33]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/Ca /kinetics/chain/kinetics[33]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[33]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[33]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[32]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[33]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[33]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca /kinetics/chain/kinetics[33]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca /kinetics/chain/kinetics[33]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[33]/Ca REAC A B addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[33]/Ca REAC A B addmsg /kinetics/chain/kinetics[33]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[33]/Ca REAC A B addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[33]/Ca REAC A B addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[33]/Ca REAC A B addmsg /kinetics/chain/kinetics[33]/Ca_diff /kinetics/chain/kinetics[33]/Ca REAC B A addmsg /kinetics/chain/kinetics[32]/Ca/diff /kinetics/chain/kinetics[33]/Ca REAC B A addmsg /kinetics/chain/kinetics[33]/Ca/diff /kinetics/chain/kinetics[33]/Ca REAC A B addmsg /kinetics/chain/kinetics[33]/Ca /kinetics/chain/kinetics[33]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/Ca /kinetics/chain/kinetics[33]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/MAPK/craf-1 /kinetics/chain/kinetics[33]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[33]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[33]/Ras/GTP-Ras /kinetics/chain/kinetics[33]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PKM/trigger_PKM /kinetics/chain/kinetics[33]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[32]/PKM/Ca_detector/diff /kinetics/chain/kinetics[33]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[33]/PKM/Ca_detector/diff /kinetics/chain/kinetics[33]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[33]/PKM/Ca_detector /kinetics/chain/kinetics[33]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PKM/Ca_detector /kinetics/chain/kinetics[33]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[33]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[33]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[33]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[33]/PKM/turn_off_activator /kinetics/chain/kinetics[33]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[32]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[33]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[33]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[33]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[33]/PKM/PKM_synthesis /kinetics/chain/kinetics[33]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[33]/PKM/AA_pool /kinetics/chain/kinetics[33]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PKM/PKM_synthesis /kinetics/chain/kinetics[33]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PKM/PKM_synthesis /kinetics/chain/kinetics[33]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[33]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[33]/PKC/PKM-zeta /kinetics/chain/kinetics[33]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PKM/degraded_PKM /kinetics/chain/kinetics[33]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[33]/PKM/PKM_degradation /kinetics/chain/kinetics[33]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[33]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[33]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[33]/PKM/trigger_PKM /kinetics/chain/kinetics[33]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[32]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[33]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[33]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[33]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[33]/PKM/Ca.detector_complex /kinetics/chain/kinetics[33]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[33]/PKM/PKM_activator /kinetics/chain/kinetics[33]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PKM/Ca.detector_complex /kinetics/chain/kinetics[33]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PKM/Ca.detector_complex /kinetics/chain/kinetics[33]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[33]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[33]/PKM/turn_off_activator /kinetics/chain/kinetics[33]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[32]/PKM/PKM_activator/diff /kinetics/chain/kinetics[33]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[33]/PKM/PKM_activator/diff /kinetics/chain/kinetics[33]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[33]/PKM/PKM_activator /kinetics/chain/kinetics[33]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PKM/PKM_activator /kinetics/chain/kinetics[33]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/PKM/PKM_synthesis /kinetics/chain/kinetics[33]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PKM/PKM_activator /kinetics/chain/kinetics[33]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca4 /kinetics/chain/kinetics[33]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PKM/Ca_detector /kinetics/chain/kinetics[33]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[33]/PKM/Ca.detector_complex /kinetics/chain/kinetics[33]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[33]/Ca_diff /kinetics/chain/kinetics[33]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[33]/Ca /kinetics/chain/kinetics[33]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[33]/Ca_input /kinetics/chain/kinetics[33]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[34]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[34]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[34]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[34]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[34]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[33]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[34]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[34]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[34]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[34]/PKC/PKC-Ca /kinetics/chain/kinetics[34]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PKC/PKC-Ca /kinetics/chain/kinetics[34]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/PKC/PKC-Ca /kinetics/chain/kinetics[34]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[34]/PKC/PKC-cytosolic /kinetics/chain/kinetics[34]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/Ca /kinetics/chain/kinetics[34]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PKC/PKC-Ca /kinetics/chain/kinetics[34]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[34]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[34]/DAG /kinetics/chain/kinetics[34]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PKC/PKC-Ca /kinetics/chain/kinetics[34]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[34]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[34]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[34]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[34]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[34]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[34]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[33]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[34]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[34]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[34]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[34]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[34]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[34]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[34]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[33]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[34]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[34]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[34]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[34]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[34]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[34]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[34]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[34]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[34]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[33]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[34]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[34]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[34]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[34]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[34]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[34]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/PKC/PKC-DAG /kinetics/chain/kinetics[34]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[34]/PKC/PKC-cytosolic /kinetics/chain/kinetics[34]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/DAG /kinetics/chain/kinetics[34]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PKC/PKC-n-DAG /kinetics/chain/kinetics[34]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[33]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[34]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[34]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[34]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[34]/PKC/PKC-DAG /kinetics/chain/kinetics[34]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PKC/PKC-DAG /kinetics/chain/kinetics[34]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[34]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[34]/PKC/PKC-n-DAG /kinetics/chain/kinetics[34]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[33]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[34]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[34]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[34]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[34]/PKC/PKC-cytosolic /kinetics/chain/kinetics[34]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PKC/PKC-cytosolic /kinetics/chain/kinetics[34]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[34]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[34]/PKM/PKM_degradation /kinetics/chain/kinetics[34]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[33]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[34]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[34]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[34]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[34]/PKC/PKM-zeta /kinetics/chain/kinetics[34]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PKC/PKM-zeta /kinetics/chain/kinetics[34]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[34]/DAG REAC A B addmsg /kinetics/chain/kinetics[34]/PKC/PKC-n-DAG /kinetics/chain/kinetics[34]/DAG REAC A B addmsg /kinetics/chain/kinetics[34]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[34]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[34]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[34]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[34]/PKC/PKM-zeta /kinetics/chain/kinetics[34]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[34]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[34]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[34]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[34]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[34]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[34]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[34]/PKC-active /kinetics/chain/kinetics[34]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[34]/MAPK/craf-1 /kinetics/chain/kinetics[34]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PKC-active /kinetics/chain/kinetics[34]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[34]/Ras/GAP /kinetics/chain/kinetics[34]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PKC-active /kinetics/chain/kinetics[34]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[34]/Ras/inact-GEF /kinetics/chain/kinetics[34]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[34]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[34]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[34]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[34]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[34]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[33]/MAPK*/diff /kinetics/chain/kinetics[34]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[34]/MAPK*/diff /kinetics/chain/kinetics[34]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[34]/MAPK* /kinetics/chain/kinetics[34]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[34]/MAPK/craf-1* /kinetics/chain/kinetics[34]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/MAPK* /kinetics/chain/kinetics[34]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/MAPK* /kinetics/chain/kinetics[34]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[34]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[34]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[34]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[34]/Ras-act-unphosph-raf /kinetics/chain/kinetics[34]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[33]/MAPK/craf-1/diff /kinetics/chain/kinetics[34]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[34]/MAPK/craf-1/diff /kinetics/chain/kinetics[34]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[34]/MAPK/craf-1 /kinetics/chain/kinetics[34]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/MAPK/craf-1 /kinetics/chain/kinetics[34]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[34]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[34]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[34]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[34]/Ras-act-craf /kinetics/chain/kinetics[34]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[34]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[34]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[34]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[34]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[33]/MAPK/craf-1*/diff /kinetics/chain/kinetics[34]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[34]/MAPK/craf-1*/diff /kinetics/chain/kinetics[34]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[34]/MAPK/craf-1* /kinetics/chain/kinetics[34]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/MAPK/craf-1* /kinetics/chain/kinetics[34]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[34]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[34]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[34]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[34]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[33]/MAPK/MAPKK/diff /kinetics/chain/kinetics[34]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[34]/MAPK/MAPKK/diff /kinetics/chain/kinetics[34]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[34]/MAPK/MAPKK /kinetics/chain/kinetics[34]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/MAPK/MAPKK /kinetics/chain/kinetics[34]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[34]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[34]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[34]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[33]/MAPK/MAPK/diff /kinetics/chain/kinetics[34]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[34]/MAPK/MAPK/diff /kinetics/chain/kinetics[34]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[34]/MAPK/MAPK /kinetics/chain/kinetics[34]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/MAPK/MAPK /kinetics/chain/kinetics[34]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[34]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[34]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[34]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[33]/MAPK/craf-1**/diff /kinetics/chain/kinetics[34]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[34]/MAPK/craf-1**/diff /kinetics/chain/kinetics[34]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[34]/MAPK/craf-1** /kinetics/chain/kinetics[34]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/MAPK/craf-1** /kinetics/chain/kinetics[34]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[34]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[34]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[34]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[34]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[34]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[34]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[34]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[33]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[34]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[34]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[34]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[34]/MAPK/MAPK-tyr /kinetics/chain/kinetics[34]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/MAPK/MAPK-tyr /kinetics/chain/kinetics[34]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[34]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[34]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[34]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[34]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[34]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[34]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[34]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[33]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[34]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[34]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[34]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[34]/MAPK/MAPK /kinetics/chain/kinetics[34]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/MAPK/MAPKK* /kinetics/chain/kinetics[34]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[34]/MAPK/MAPK-tyr /kinetics/chain/kinetics[34]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/MAPK/MAPKK* /kinetics/chain/kinetics[34]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[34]/MAPK/MAPKK* /kinetics/chain/kinetics[34]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/MAPK/MAPKK* /kinetics/chain/kinetics[34]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[34]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[34]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[34]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[34]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[34]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[34]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[34]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[34]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[33]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[34]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[34]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[34]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[34]/MAPK/MAPKK-ser /kinetics/chain/kinetics[34]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/MAPK/MAPKK-ser /kinetics/chain/kinetics[34]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[34]/Ras-act-unphosph-raf /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[33]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[34]/MAPK/MAPKK /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[34]/MAPK/MAPKK-ser /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[34]/Ras-act-craf /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[33]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[34]/MAPK/MAPKK /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[34]/MAPK/MAPKK-ser /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[34]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[34]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[34]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[33]/MKP-1/diff /kinetics/chain/kinetics[34]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[34]/MKP-1/diff /kinetics/chain/kinetics[34]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[34]/MAPK/MAPK-tyr /kinetics/chain/kinetics[34]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/MKP-1 /kinetics/chain/kinetics[34]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[34]/MAPK* /kinetics/chain/kinetics[34]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/MKP-1 /kinetics/chain/kinetics[34]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[34]/MKP-1 /kinetics/chain/kinetics[34]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/MKP-1 /kinetics/chain/kinetics[34]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/MAPK/craf-1* /kinetics/chain/kinetics[34]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[34]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[34]/Ras/GTP-Ras /kinetics/chain/kinetics[34]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[34]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[34]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[34]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[34]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[34]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[34]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[34]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[33]/PPhosphatase2A/diff /kinetics/chain/kinetics[34]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[34]/PPhosphatase2A/diff /kinetics/chain/kinetics[34]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[34]/MAPK/craf-1* /kinetics/chain/kinetics[34]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PPhosphatase2A /kinetics/chain/kinetics[34]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[34]/MAPK/MAPKK* /kinetics/chain/kinetics[34]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PPhosphatase2A /kinetics/chain/kinetics[34]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[34]/MAPK/MAPKK-ser /kinetics/chain/kinetics[34]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PPhosphatase2A /kinetics/chain/kinetics[34]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[34]/MAPK/craf-1** /kinetics/chain/kinetics[34]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PPhosphatase2A /kinetics/chain/kinetics[34]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[34]/PPhosphatase2A /kinetics/chain/kinetics[34]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PPhosphatase2A /kinetics/chain/kinetics[34]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/Ras/inact-GEF /kinetics/chain/kinetics[34]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[34]/Ras/GEF* /kinetics/chain/kinetics[34]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[34]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[34]/Ras/dephosph-GEF /kinetics/chain/kinetics[34]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[34]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[34]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[34]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[34]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[33]/Ras/inact-GEF/diff /kinetics/chain/kinetics[34]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[34]/Ras/inact-GEF/diff /kinetics/chain/kinetics[34]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[34]/Ras/inact-GEF /kinetics/chain/kinetics[34]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[34]/Ras/GDP-Ras /kinetics/chain/kinetics[34]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/Ras/inact-GEF /kinetics/chain/kinetics[34]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/Ras/inact-GEF /kinetics/chain/kinetics[34]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[34]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[34]/Ras/dephosph-GEF /kinetics/chain/kinetics[34]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[34]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[34]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[33]/Ras/GEF*/diff /kinetics/chain/kinetics[34]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[34]/Ras/GEF*/diff /kinetics/chain/kinetics[34]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[34]/Ras/GEF* /kinetics/chain/kinetics[34]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[34]/Ras/GDP-Ras /kinetics/chain/kinetics[34]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/Ras/GEF* /kinetics/chain/kinetics[34]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/Ras/GEF* /kinetics/chain/kinetics[34]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/Ras-act-craf /kinetics/chain/kinetics[34]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[34]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[34]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[34]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[34]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[34]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[34]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[34]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[34]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[34]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[34]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[34]/Ras-act-unphosph-raf /kinetics/chain/kinetics[34]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[33]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[34]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[34]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[34]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[34]/Ras/GTP-Ras /kinetics/chain/kinetics[34]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/Ras/GTP-Ras /kinetics/chain/kinetics[34]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[34]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[34]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[34]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[34]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[34]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[34]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[34]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[34]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[34]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[33]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[34]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[34]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[34]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[34]/Ras/GDP-Ras /kinetics/chain/kinetics[34]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/Ras/GDP-Ras /kinetics/chain/kinetics[34]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/Ras/GTP-Ras /kinetics/chain/kinetics[34]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/Ras/GDP-Ras /kinetics/chain/kinetics[34]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[34]/Ras/GAP* /kinetics/chain/kinetics[34]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/Ras/GAP /kinetics/chain/kinetics[34]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[34]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[34]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[34]/Ras/dephosph-GAP /kinetics/chain/kinetics[34]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[33]/Ras/GAP*/diff /kinetics/chain/kinetics[34]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[34]/Ras/GAP*/diff /kinetics/chain/kinetics[34]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[34]/Ras/GAP* /kinetics/chain/kinetics[34]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/Ras/GAP* /kinetics/chain/kinetics[34]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[34]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[34]/Ras/dephosph-GAP /kinetics/chain/kinetics[34]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[34]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[34]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[33]/Ras/GAP/diff /kinetics/chain/kinetics[34]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[34]/Ras/GAP/diff /kinetics/chain/kinetics[34]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[34]/Ras/GTP-Ras /kinetics/chain/kinetics[34]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/Ras/GAP /kinetics/chain/kinetics[34]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[34]/Ras/GAP /kinetics/chain/kinetics[34]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/Ras/GAP /kinetics/chain/kinetics[34]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/Ras/inact-GEF /kinetics/chain/kinetics[34]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/Ras/CaM-GEF /kinetics/chain/kinetics[34]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca4 /kinetics/chain/kinetics[34]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[34]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[34]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[34]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[33]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[34]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[34]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[34]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[34]/Ras/GDP-Ras /kinetics/chain/kinetics[34]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/Ras/CaM-GEF /kinetics/chain/kinetics[34]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[34]/Ras/CaM-GEF /kinetics/chain/kinetics[34]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/Ras/CaM-GEF /kinetics/chain/kinetics[34]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[34]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[33]/CaM/CaM/diff /kinetics/chain/kinetics[34]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[34]/CaM/CaM/diff /kinetics/chain/kinetics[34]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[34]/CaM/CaM /kinetics/chain/kinetics[34]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/CaM/CaM /kinetics/chain/kinetics[34]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca3 /kinetics/chain/kinetics[34]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca4 /kinetics/chain/kinetics[34]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[34]/Ca /kinetics/chain/kinetics[34]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[34]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[34]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[34]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[34]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca3 /kinetics/chain/kinetics[34]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca3 /kinetics/chain/kinetics[34]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[34]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[34]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[34]/PKM/trigger_PKM /kinetics/chain/kinetics[34]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[34]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[34]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca4 /kinetics/chain/kinetics[34]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca4 /kinetics/chain/kinetics[34]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/CaM/CaM /kinetics/chain/kinetics[34]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca /kinetics/chain/kinetics[34]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[34]/Ca /kinetics/chain/kinetics[34]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[34]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[34]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[34]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[34]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca2 /kinetics/chain/kinetics[34]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca2 /kinetics/chain/kinetics[34]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca3 /kinetics/chain/kinetics[34]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca2 /kinetics/chain/kinetics[34]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/Ca /kinetics/chain/kinetics[34]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca2 /kinetics/chain/kinetics[34]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca /kinetics/chain/kinetics[34]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/Ca /kinetics/chain/kinetics[34]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[34]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[34]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[33]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[34]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[34]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca /kinetics/chain/kinetics[34]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca /kinetics/chain/kinetics[34]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[34]/Ca REAC A B addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[34]/Ca REAC A B addmsg /kinetics/chain/kinetics[34]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[34]/Ca REAC A B addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[34]/Ca REAC A B addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[34]/Ca REAC A B addmsg /kinetics/chain/kinetics[34]/Ca_diff /kinetics/chain/kinetics[34]/Ca REAC B A addmsg /kinetics/chain/kinetics[33]/Ca/diff /kinetics/chain/kinetics[34]/Ca REAC B A addmsg /kinetics/chain/kinetics[34]/Ca/diff /kinetics/chain/kinetics[34]/Ca REAC A B addmsg /kinetics/chain/kinetics[34]/Ca /kinetics/chain/kinetics[34]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/Ca /kinetics/chain/kinetics[34]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/MAPK/craf-1 /kinetics/chain/kinetics[34]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[34]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[34]/Ras/GTP-Ras /kinetics/chain/kinetics[34]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PKM/trigger_PKM /kinetics/chain/kinetics[34]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[33]/PKM/Ca_detector/diff /kinetics/chain/kinetics[34]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[34]/PKM/Ca_detector/diff /kinetics/chain/kinetics[34]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[34]/PKM/Ca_detector /kinetics/chain/kinetics[34]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PKM/Ca_detector /kinetics/chain/kinetics[34]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[34]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[34]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[34]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[34]/PKM/turn_off_activator /kinetics/chain/kinetics[34]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[33]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[34]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[34]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[34]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[34]/PKM/PKM_synthesis /kinetics/chain/kinetics[34]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[34]/PKM/AA_pool /kinetics/chain/kinetics[34]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PKM/PKM_synthesis /kinetics/chain/kinetics[34]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PKM/PKM_synthesis /kinetics/chain/kinetics[34]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[34]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[34]/PKC/PKM-zeta /kinetics/chain/kinetics[34]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PKM/degraded_PKM /kinetics/chain/kinetics[34]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[34]/PKM/PKM_degradation /kinetics/chain/kinetics[34]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[34]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[34]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[34]/PKM/trigger_PKM /kinetics/chain/kinetics[34]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[33]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[34]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[34]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[34]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[34]/PKM/Ca.detector_complex /kinetics/chain/kinetics[34]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[34]/PKM/PKM_activator /kinetics/chain/kinetics[34]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PKM/Ca.detector_complex /kinetics/chain/kinetics[34]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PKM/Ca.detector_complex /kinetics/chain/kinetics[34]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[34]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[34]/PKM/turn_off_activator /kinetics/chain/kinetics[34]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[33]/PKM/PKM_activator/diff /kinetics/chain/kinetics[34]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[34]/PKM/PKM_activator/diff /kinetics/chain/kinetics[34]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[34]/PKM/PKM_activator /kinetics/chain/kinetics[34]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PKM/PKM_activator /kinetics/chain/kinetics[34]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/PKM/PKM_synthesis /kinetics/chain/kinetics[34]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PKM/PKM_activator /kinetics/chain/kinetics[34]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca4 /kinetics/chain/kinetics[34]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PKM/Ca_detector /kinetics/chain/kinetics[34]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[34]/PKM/Ca.detector_complex /kinetics/chain/kinetics[34]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[34]/Ca_diff /kinetics/chain/kinetics[34]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[34]/Ca /kinetics/chain/kinetics[34]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[34]/Ca_input /kinetics/chain/kinetics[34]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[35]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[35]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[35]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[35]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[35]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[34]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[35]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[35]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[35]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[35]/PKC/PKC-Ca /kinetics/chain/kinetics[35]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PKC/PKC-Ca /kinetics/chain/kinetics[35]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/PKC/PKC-Ca /kinetics/chain/kinetics[35]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[35]/PKC/PKC-cytosolic /kinetics/chain/kinetics[35]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/Ca /kinetics/chain/kinetics[35]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PKC/PKC-Ca /kinetics/chain/kinetics[35]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[35]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[35]/DAG /kinetics/chain/kinetics[35]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PKC/PKC-Ca /kinetics/chain/kinetics[35]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[35]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[35]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[35]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[35]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[35]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[35]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[34]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[35]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[35]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[35]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[35]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[35]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[35]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[35]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[34]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[35]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[35]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[35]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[35]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[35]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[35]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[35]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[35]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[35]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[34]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[35]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[35]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[35]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[35]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[35]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[35]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/PKC/PKC-DAG /kinetics/chain/kinetics[35]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[35]/PKC/PKC-cytosolic /kinetics/chain/kinetics[35]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/DAG /kinetics/chain/kinetics[35]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PKC/PKC-n-DAG /kinetics/chain/kinetics[35]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[34]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[35]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[35]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[35]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[35]/PKC/PKC-DAG /kinetics/chain/kinetics[35]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PKC/PKC-DAG /kinetics/chain/kinetics[35]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[35]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[35]/PKC/PKC-n-DAG /kinetics/chain/kinetics[35]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[34]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[35]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[35]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[35]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[35]/PKC/PKC-cytosolic /kinetics/chain/kinetics[35]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PKC/PKC-cytosolic /kinetics/chain/kinetics[35]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[35]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[35]/PKM/PKM_degradation /kinetics/chain/kinetics[35]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[34]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[35]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[35]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[35]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[35]/PKC/PKM-zeta /kinetics/chain/kinetics[35]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PKC/PKM-zeta /kinetics/chain/kinetics[35]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[35]/DAG REAC A B addmsg /kinetics/chain/kinetics[35]/PKC/PKC-n-DAG /kinetics/chain/kinetics[35]/DAG REAC A B addmsg /kinetics/chain/kinetics[35]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[35]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[35]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[35]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[35]/PKC/PKM-zeta /kinetics/chain/kinetics[35]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[35]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[35]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[35]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[35]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[35]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[35]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[35]/PKC-active /kinetics/chain/kinetics[35]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[35]/MAPK/craf-1 /kinetics/chain/kinetics[35]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PKC-active /kinetics/chain/kinetics[35]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[35]/Ras/GAP /kinetics/chain/kinetics[35]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PKC-active /kinetics/chain/kinetics[35]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[35]/Ras/inact-GEF /kinetics/chain/kinetics[35]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[35]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[35]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[35]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[35]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[35]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[34]/MAPK*/diff /kinetics/chain/kinetics[35]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[35]/MAPK*/diff /kinetics/chain/kinetics[35]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[35]/MAPK* /kinetics/chain/kinetics[35]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[35]/MAPK/craf-1* /kinetics/chain/kinetics[35]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/MAPK* /kinetics/chain/kinetics[35]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/MAPK* /kinetics/chain/kinetics[35]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[35]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[35]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[35]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[35]/Ras-act-unphosph-raf /kinetics/chain/kinetics[35]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[34]/MAPK/craf-1/diff /kinetics/chain/kinetics[35]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[35]/MAPK/craf-1/diff /kinetics/chain/kinetics[35]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[35]/MAPK/craf-1 /kinetics/chain/kinetics[35]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/MAPK/craf-1 /kinetics/chain/kinetics[35]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[35]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[35]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[35]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[35]/Ras-act-craf /kinetics/chain/kinetics[35]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[35]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[35]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[35]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[35]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[34]/MAPK/craf-1*/diff /kinetics/chain/kinetics[35]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[35]/MAPK/craf-1*/diff /kinetics/chain/kinetics[35]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[35]/MAPK/craf-1* /kinetics/chain/kinetics[35]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/MAPK/craf-1* /kinetics/chain/kinetics[35]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[35]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[35]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[35]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[35]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[35]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[34]/MAPK/MAPKK/diff /kinetics/chain/kinetics[35]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[35]/MAPK/MAPKK/diff /kinetics/chain/kinetics[35]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[35]/MAPK/MAPKK /kinetics/chain/kinetics[35]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/MAPK/MAPKK /kinetics/chain/kinetics[35]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[35]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[35]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[35]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[34]/MAPK/MAPK/diff /kinetics/chain/kinetics[35]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[35]/MAPK/MAPK/diff /kinetics/chain/kinetics[35]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[35]/MAPK/MAPK /kinetics/chain/kinetics[35]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/MAPK/MAPK /kinetics/chain/kinetics[35]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[35]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[35]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[35]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[34]/MAPK/craf-1**/diff /kinetics/chain/kinetics[35]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[35]/MAPK/craf-1**/diff /kinetics/chain/kinetics[35]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[35]/MAPK/craf-1** /kinetics/chain/kinetics[35]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/MAPK/craf-1** /kinetics/chain/kinetics[35]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[35]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[35]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[35]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[35]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[35]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[35]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[35]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[34]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[35]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[35]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[35]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[35]/MAPK/MAPK-tyr /kinetics/chain/kinetics[35]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/MAPK/MAPK-tyr /kinetics/chain/kinetics[35]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[35]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[35]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[35]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[35]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[35]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[35]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[35]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[35]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[35]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[34]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[35]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[35]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[35]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[35]/MAPK/MAPK /kinetics/chain/kinetics[35]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/MAPK/MAPKK* /kinetics/chain/kinetics[35]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[35]/MAPK/MAPK-tyr /kinetics/chain/kinetics[35]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/MAPK/MAPKK* /kinetics/chain/kinetics[35]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[35]/MAPK/MAPKK* /kinetics/chain/kinetics[35]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/MAPK/MAPKK* /kinetics/chain/kinetics[35]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[35]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[35]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[35]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[35]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[35]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[35]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[35]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[35]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[35]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[35]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[35]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[34]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[35]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[35]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[35]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[35]/MAPK/MAPKK-ser /kinetics/chain/kinetics[35]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/MAPK/MAPKK-ser /kinetics/chain/kinetics[35]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[35]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[35]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[35]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[35]/Ras-act-unphosph-raf /kinetics/chain/kinetics[35]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[35]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[35]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[35]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[35]/MAPK/MAPKK /kinetics/chain/kinetics[35]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[35]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[35]/MAPK/MAPKK-ser /kinetics/chain/kinetics[35]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[35]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[35]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[35]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[35]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[35]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[35]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[35]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[35]/Ras-act-craf /kinetics/chain/kinetics[35]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[35]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[35]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[35]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[35]/MAPK/MAPKK /kinetics/chain/kinetics[35]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[35]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[35]/MAPK/MAPKK-ser /kinetics/chain/kinetics[35]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[35]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[35]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[35]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[35]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[35]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[35]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[35]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[34]/MKP-1/diff /kinetics/chain/kinetics[35]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[35]/MKP-1/diff /kinetics/chain/kinetics[35]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[35]/MAPK/MAPK-tyr /kinetics/chain/kinetics[35]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/MKP-1 /kinetics/chain/kinetics[35]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[35]/MAPK* /kinetics/chain/kinetics[35]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/MKP-1 /kinetics/chain/kinetics[35]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[35]/MKP-1 /kinetics/chain/kinetics[35]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/MKP-1 /kinetics/chain/kinetics[35]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/MAPK/craf-1* /kinetics/chain/kinetics[35]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[35]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[35]/Ras/GTP-Ras /kinetics/chain/kinetics[35]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[35]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[35]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[35]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[35]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[35]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[35]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[35]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[34]/PPhosphatase2A/diff /kinetics/chain/kinetics[35]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[35]/PPhosphatase2A/diff /kinetics/chain/kinetics[35]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[35]/MAPK/craf-1* /kinetics/chain/kinetics[35]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PPhosphatase2A /kinetics/chain/kinetics[35]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[35]/MAPK/MAPKK* /kinetics/chain/kinetics[35]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PPhosphatase2A /kinetics/chain/kinetics[35]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[35]/MAPK/MAPKK-ser /kinetics/chain/kinetics[35]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PPhosphatase2A /kinetics/chain/kinetics[35]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[35]/MAPK/craf-1** /kinetics/chain/kinetics[35]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PPhosphatase2A /kinetics/chain/kinetics[35]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[35]/PPhosphatase2A /kinetics/chain/kinetics[35]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PPhosphatase2A /kinetics/chain/kinetics[35]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/Ras/inact-GEF /kinetics/chain/kinetics[35]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[35]/Ras/GEF* /kinetics/chain/kinetics[35]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[35]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[35]/Ras/dephosph-GEF /kinetics/chain/kinetics[35]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[35]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[35]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[35]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[35]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[34]/Ras/inact-GEF/diff /kinetics/chain/kinetics[35]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[35]/Ras/inact-GEF/diff /kinetics/chain/kinetics[35]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[35]/Ras/inact-GEF /kinetics/chain/kinetics[35]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[35]/Ras/GDP-Ras /kinetics/chain/kinetics[35]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/Ras/inact-GEF /kinetics/chain/kinetics[35]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/Ras/inact-GEF /kinetics/chain/kinetics[35]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[35]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[35]/Ras/dephosph-GEF /kinetics/chain/kinetics[35]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[35]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[35]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[34]/Ras/GEF*/diff /kinetics/chain/kinetics[35]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[35]/Ras/GEF*/diff /kinetics/chain/kinetics[35]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[35]/Ras/GEF* /kinetics/chain/kinetics[35]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[35]/Ras/GDP-Ras /kinetics/chain/kinetics[35]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/Ras/GEF* /kinetics/chain/kinetics[35]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/Ras/GEF* /kinetics/chain/kinetics[35]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/Ras-act-craf /kinetics/chain/kinetics[35]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[35]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[35]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[35]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[35]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[35]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[35]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[35]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[35]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[35]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[35]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[35]/Ras-act-unphosph-raf /kinetics/chain/kinetics[35]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[34]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[35]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[35]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[35]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[35]/Ras/GTP-Ras /kinetics/chain/kinetics[35]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/Ras/GTP-Ras /kinetics/chain/kinetics[35]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[35]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[35]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[35]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[35]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[35]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[35]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[35]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[35]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[35]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[34]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[35]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[35]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[35]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[35]/Ras/GDP-Ras /kinetics/chain/kinetics[35]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/Ras/GDP-Ras /kinetics/chain/kinetics[35]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/Ras/GTP-Ras /kinetics/chain/kinetics[35]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/Ras/GDP-Ras /kinetics/chain/kinetics[35]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[35]/Ras/GAP* /kinetics/chain/kinetics[35]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/Ras/GAP /kinetics/chain/kinetics[35]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[35]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[35]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[35]/Ras/dephosph-GAP /kinetics/chain/kinetics[35]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[34]/Ras/GAP*/diff /kinetics/chain/kinetics[35]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[35]/Ras/GAP*/diff /kinetics/chain/kinetics[35]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[35]/Ras/GAP* /kinetics/chain/kinetics[35]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/Ras/GAP* /kinetics/chain/kinetics[35]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[35]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[35]/Ras/dephosph-GAP /kinetics/chain/kinetics[35]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[35]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[35]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[34]/Ras/GAP/diff /kinetics/chain/kinetics[35]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[35]/Ras/GAP/diff /kinetics/chain/kinetics[35]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[35]/Ras/GTP-Ras /kinetics/chain/kinetics[35]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/Ras/GAP /kinetics/chain/kinetics[35]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[35]/Ras/GAP /kinetics/chain/kinetics[35]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/Ras/GAP /kinetics/chain/kinetics[35]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/Ras/inact-GEF /kinetics/chain/kinetics[35]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/Ras/CaM-GEF /kinetics/chain/kinetics[35]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca4 /kinetics/chain/kinetics[35]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[35]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[35]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[35]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[34]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[35]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[35]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[35]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[35]/Ras/GDP-Ras /kinetics/chain/kinetics[35]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/Ras/CaM-GEF /kinetics/chain/kinetics[35]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[35]/Ras/CaM-GEF /kinetics/chain/kinetics[35]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/Ras/CaM-GEF /kinetics/chain/kinetics[35]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[35]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[34]/CaM/CaM/diff /kinetics/chain/kinetics[35]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[35]/CaM/CaM/diff /kinetics/chain/kinetics[35]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[35]/CaM/CaM /kinetics/chain/kinetics[35]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/CaM/CaM /kinetics/chain/kinetics[35]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca3 /kinetics/chain/kinetics[35]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca4 /kinetics/chain/kinetics[35]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[35]/Ca /kinetics/chain/kinetics[35]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[35]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[35]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[35]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[35]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca3 /kinetics/chain/kinetics[35]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca3 /kinetics/chain/kinetics[35]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[35]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[35]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[35]/PKM/trigger_PKM /kinetics/chain/kinetics[35]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[35]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[35]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca4 /kinetics/chain/kinetics[35]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca4 /kinetics/chain/kinetics[35]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/CaM/CaM /kinetics/chain/kinetics[35]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca /kinetics/chain/kinetics[35]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[35]/Ca /kinetics/chain/kinetics[35]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[35]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[35]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[35]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[35]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca2 /kinetics/chain/kinetics[35]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca2 /kinetics/chain/kinetics[35]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca3 /kinetics/chain/kinetics[35]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca2 /kinetics/chain/kinetics[35]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/Ca /kinetics/chain/kinetics[35]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca2 /kinetics/chain/kinetics[35]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca /kinetics/chain/kinetics[35]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/Ca /kinetics/chain/kinetics[35]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[35]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[35]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[34]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[35]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[35]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca /kinetics/chain/kinetics[35]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca /kinetics/chain/kinetics[35]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[35]/Ca REAC A B addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[35]/Ca REAC A B addmsg /kinetics/chain/kinetics[35]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[35]/Ca REAC A B addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[35]/Ca REAC A B addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[35]/Ca REAC A B addmsg /kinetics/chain/kinetics[35]/Ca_diff /kinetics/chain/kinetics[35]/Ca REAC B A addmsg /kinetics/chain/kinetics[34]/Ca/diff /kinetics/chain/kinetics[35]/Ca REAC B A addmsg /kinetics/chain/kinetics[35]/Ca/diff /kinetics/chain/kinetics[35]/Ca REAC A B addmsg /kinetics/chain/kinetics[35]/Ca /kinetics/chain/kinetics[35]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/Ca /kinetics/chain/kinetics[35]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/MAPK/craf-1 /kinetics/chain/kinetics[35]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[35]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[35]/Ras/GTP-Ras /kinetics/chain/kinetics[35]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PKM/trigger_PKM /kinetics/chain/kinetics[35]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[34]/PKM/Ca_detector/diff /kinetics/chain/kinetics[35]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[35]/PKM/Ca_detector/diff /kinetics/chain/kinetics[35]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[35]/PKM/Ca_detector /kinetics/chain/kinetics[35]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PKM/Ca_detector /kinetics/chain/kinetics[35]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[35]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[35]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[35]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[35]/PKM/turn_off_activator /kinetics/chain/kinetics[35]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[34]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[35]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[35]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[35]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[35]/PKM/PKM_synthesis /kinetics/chain/kinetics[35]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[35]/PKM/AA_pool /kinetics/chain/kinetics[35]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PKM/PKM_synthesis /kinetics/chain/kinetics[35]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PKM/PKM_synthesis /kinetics/chain/kinetics[35]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[35]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[35]/PKC/PKM-zeta /kinetics/chain/kinetics[35]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PKM/degraded_PKM /kinetics/chain/kinetics[35]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[35]/PKM/PKM_degradation /kinetics/chain/kinetics[35]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[35]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[35]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[35]/PKM/trigger_PKM /kinetics/chain/kinetics[35]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[34]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[35]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[35]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[35]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[35]/PKM/Ca.detector_complex /kinetics/chain/kinetics[35]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[35]/PKM/PKM_activator /kinetics/chain/kinetics[35]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PKM/Ca.detector_complex /kinetics/chain/kinetics[35]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PKM/Ca.detector_complex /kinetics/chain/kinetics[35]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[35]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[35]/PKM/turn_off_activator /kinetics/chain/kinetics[35]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[34]/PKM/PKM_activator/diff /kinetics/chain/kinetics[35]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[35]/PKM/PKM_activator/diff /kinetics/chain/kinetics[35]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[35]/PKM/PKM_activator /kinetics/chain/kinetics[35]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PKM/PKM_activator /kinetics/chain/kinetics[35]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/PKM/PKM_synthesis /kinetics/chain/kinetics[35]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PKM/PKM_activator /kinetics/chain/kinetics[35]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca4 /kinetics/chain/kinetics[35]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PKM/Ca_detector /kinetics/chain/kinetics[35]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[35]/PKM/Ca.detector_complex /kinetics/chain/kinetics[35]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[35]/Ca_diff /kinetics/chain/kinetics[35]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[35]/Ca /kinetics/chain/kinetics[35]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[35]/Ca_input /kinetics/chain/kinetics[35]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[36]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[36]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[36]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[36]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[36]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[35]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[36]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[36]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[36]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[36]/PKC/PKC-Ca /kinetics/chain/kinetics[36]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PKC/PKC-Ca /kinetics/chain/kinetics[36]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/PKC/PKC-Ca /kinetics/chain/kinetics[36]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[36]/PKC/PKC-cytosolic /kinetics/chain/kinetics[36]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/Ca /kinetics/chain/kinetics[36]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PKC/PKC-Ca /kinetics/chain/kinetics[36]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[36]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[36]/DAG /kinetics/chain/kinetics[36]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PKC/PKC-Ca /kinetics/chain/kinetics[36]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[36]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[36]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[36]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[36]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[36]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[36]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[35]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[36]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[36]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[36]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[36]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[36]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[36]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[36]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[35]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[36]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[36]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[36]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[36]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[36]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[36]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[36]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[36]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[36]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[35]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[36]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[36]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[36]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[36]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[36]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[36]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/PKC/PKC-DAG /kinetics/chain/kinetics[36]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[36]/PKC/PKC-cytosolic /kinetics/chain/kinetics[36]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/DAG /kinetics/chain/kinetics[36]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PKC/PKC-n-DAG /kinetics/chain/kinetics[36]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[35]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[36]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[36]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[36]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[36]/PKC/PKC-DAG /kinetics/chain/kinetics[36]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PKC/PKC-DAG /kinetics/chain/kinetics[36]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[36]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[36]/PKC/PKC-n-DAG /kinetics/chain/kinetics[36]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[35]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[36]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[36]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[36]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[36]/PKC/PKC-cytosolic /kinetics/chain/kinetics[36]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PKC/PKC-cytosolic /kinetics/chain/kinetics[36]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[36]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[36]/PKM/PKM_degradation /kinetics/chain/kinetics[36]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[35]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[36]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[36]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[36]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[36]/PKC/PKM-zeta /kinetics/chain/kinetics[36]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PKC/PKM-zeta /kinetics/chain/kinetics[36]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[36]/DAG REAC A B addmsg /kinetics/chain/kinetics[36]/PKC/PKC-n-DAG /kinetics/chain/kinetics[36]/DAG REAC A B addmsg /kinetics/chain/kinetics[36]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[36]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[36]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[36]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[36]/PKC/PKM-zeta /kinetics/chain/kinetics[36]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[36]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[36]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[36]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[36]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[36]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[36]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[36]/PKC-active /kinetics/chain/kinetics[36]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[36]/MAPK/craf-1 /kinetics/chain/kinetics[36]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PKC-active /kinetics/chain/kinetics[36]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[36]/Ras/GAP /kinetics/chain/kinetics[36]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PKC-active /kinetics/chain/kinetics[36]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[36]/Ras/inact-GEF /kinetics/chain/kinetics[36]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[36]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[36]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[36]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[36]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[36]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[35]/MAPK*/diff /kinetics/chain/kinetics[36]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[36]/MAPK*/diff /kinetics/chain/kinetics[36]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[36]/MAPK* /kinetics/chain/kinetics[36]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[36]/MAPK/craf-1* /kinetics/chain/kinetics[36]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/MAPK* /kinetics/chain/kinetics[36]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/MAPK* /kinetics/chain/kinetics[36]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[36]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[36]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[36]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[36]/Ras-act-unphosph-raf /kinetics/chain/kinetics[36]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[35]/MAPK/craf-1/diff /kinetics/chain/kinetics[36]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[36]/MAPK/craf-1/diff /kinetics/chain/kinetics[36]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[36]/MAPK/craf-1 /kinetics/chain/kinetics[36]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/MAPK/craf-1 /kinetics/chain/kinetics[36]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[36]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[36]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[36]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[36]/Ras-act-craf /kinetics/chain/kinetics[36]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[36]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[36]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[36]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[36]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[35]/MAPK/craf-1*/diff /kinetics/chain/kinetics[36]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[36]/MAPK/craf-1*/diff /kinetics/chain/kinetics[36]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[36]/MAPK/craf-1* /kinetics/chain/kinetics[36]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/MAPK/craf-1* /kinetics/chain/kinetics[36]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[36]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[36]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[36]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[36]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[36]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[35]/MAPK/MAPKK/diff /kinetics/chain/kinetics[36]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[36]/MAPK/MAPKK/diff /kinetics/chain/kinetics[36]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[36]/MAPK/MAPKK /kinetics/chain/kinetics[36]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/MAPK/MAPKK /kinetics/chain/kinetics[36]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[36]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[36]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[36]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[35]/MAPK/MAPK/diff /kinetics/chain/kinetics[36]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[36]/MAPK/MAPK/diff /kinetics/chain/kinetics[36]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[36]/MAPK/MAPK /kinetics/chain/kinetics[36]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/MAPK/MAPK /kinetics/chain/kinetics[36]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[36]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[36]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[36]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[35]/MAPK/craf-1**/diff /kinetics/chain/kinetics[36]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[36]/MAPK/craf-1**/diff /kinetics/chain/kinetics[36]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[36]/MAPK/craf-1** /kinetics/chain/kinetics[36]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/MAPK/craf-1** /kinetics/chain/kinetics[36]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[36]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[36]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[36]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[36]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[36]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[36]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[36]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[35]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[36]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[36]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[36]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[36]/MAPK/MAPK-tyr /kinetics/chain/kinetics[36]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/MAPK/MAPK-tyr /kinetics/chain/kinetics[36]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[36]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[36]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[36]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[36]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[36]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[36]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[36]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[36]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[36]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[35]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[36]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[36]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[36]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[36]/MAPK/MAPK /kinetics/chain/kinetics[36]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/MAPK/MAPKK* /kinetics/chain/kinetics[36]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[36]/MAPK/MAPK-tyr /kinetics/chain/kinetics[36]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/MAPK/MAPKK* /kinetics/chain/kinetics[36]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[36]/MAPK/MAPKK* /kinetics/chain/kinetics[36]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/MAPK/MAPKK* /kinetics/chain/kinetics[36]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[36]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[36]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[36]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[36]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[36]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[36]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[36]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[36]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[36]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[36]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[36]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[35]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[36]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[36]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[36]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[36]/MAPK/MAPKK-ser /kinetics/chain/kinetics[36]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/MAPK/MAPKK-ser /kinetics/chain/kinetics[36]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[36]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[36]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[36]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[36]/Ras-act-unphosph-raf /kinetics/chain/kinetics[36]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[35]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[36]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[36]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[36]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[36]/MAPK/MAPKK /kinetics/chain/kinetics[36]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[36]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[36]/MAPK/MAPKK-ser /kinetics/chain/kinetics[36]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[36]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[36]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[36]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[36]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[36]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[36]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[36]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[36]/Ras-act-craf /kinetics/chain/kinetics[36]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[35]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[36]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[36]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[36]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[36]/MAPK/MAPKK /kinetics/chain/kinetics[36]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[36]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[36]/MAPK/MAPKK-ser /kinetics/chain/kinetics[36]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[36]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[36]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[36]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[36]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[36]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[36]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[36]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[35]/MKP-1/diff /kinetics/chain/kinetics[36]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[36]/MKP-1/diff /kinetics/chain/kinetics[36]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[36]/MAPK/MAPK-tyr /kinetics/chain/kinetics[36]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/MKP-1 /kinetics/chain/kinetics[36]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[36]/MAPK* /kinetics/chain/kinetics[36]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/MKP-1 /kinetics/chain/kinetics[36]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[36]/MKP-1 /kinetics/chain/kinetics[36]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/MKP-1 /kinetics/chain/kinetics[36]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/MAPK/craf-1* /kinetics/chain/kinetics[36]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[36]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[36]/Ras/GTP-Ras /kinetics/chain/kinetics[36]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[36]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[36]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[36]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[36]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[36]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[36]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[36]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[35]/PPhosphatase2A/diff /kinetics/chain/kinetics[36]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[36]/PPhosphatase2A/diff /kinetics/chain/kinetics[36]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[36]/MAPK/craf-1* /kinetics/chain/kinetics[36]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PPhosphatase2A /kinetics/chain/kinetics[36]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[36]/MAPK/MAPKK* /kinetics/chain/kinetics[36]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PPhosphatase2A /kinetics/chain/kinetics[36]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[36]/MAPK/MAPKK-ser /kinetics/chain/kinetics[36]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PPhosphatase2A /kinetics/chain/kinetics[36]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[36]/MAPK/craf-1** /kinetics/chain/kinetics[36]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PPhosphatase2A /kinetics/chain/kinetics[36]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[36]/PPhosphatase2A /kinetics/chain/kinetics[36]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PPhosphatase2A /kinetics/chain/kinetics[36]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/Ras/inact-GEF /kinetics/chain/kinetics[36]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[36]/Ras/GEF* /kinetics/chain/kinetics[36]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[36]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[36]/Ras/dephosph-GEF /kinetics/chain/kinetics[36]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[36]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[36]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[36]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[36]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[35]/Ras/inact-GEF/diff /kinetics/chain/kinetics[36]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[36]/Ras/inact-GEF/diff /kinetics/chain/kinetics[36]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[36]/Ras/inact-GEF /kinetics/chain/kinetics[36]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[36]/Ras/GDP-Ras /kinetics/chain/kinetics[36]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/Ras/inact-GEF /kinetics/chain/kinetics[36]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/Ras/inact-GEF /kinetics/chain/kinetics[36]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[36]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[36]/Ras/dephosph-GEF /kinetics/chain/kinetics[36]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[36]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[36]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[35]/Ras/GEF*/diff /kinetics/chain/kinetics[36]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[36]/Ras/GEF*/diff /kinetics/chain/kinetics[36]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[36]/Ras/GEF* /kinetics/chain/kinetics[36]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[36]/Ras/GDP-Ras /kinetics/chain/kinetics[36]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/Ras/GEF* /kinetics/chain/kinetics[36]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/Ras/GEF* /kinetics/chain/kinetics[36]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/Ras-act-craf /kinetics/chain/kinetics[36]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[36]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[36]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[36]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[36]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[36]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[36]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[36]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[36]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[36]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[36]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[36]/Ras-act-unphosph-raf /kinetics/chain/kinetics[36]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[35]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[36]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[36]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[36]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[36]/Ras/GTP-Ras /kinetics/chain/kinetics[36]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/Ras/GTP-Ras /kinetics/chain/kinetics[36]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[36]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[36]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[36]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[36]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[36]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[36]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[36]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[36]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[36]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[35]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[36]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[36]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[36]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[36]/Ras/GDP-Ras /kinetics/chain/kinetics[36]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/Ras/GDP-Ras /kinetics/chain/kinetics[36]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/Ras/GTP-Ras /kinetics/chain/kinetics[36]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/Ras/GDP-Ras /kinetics/chain/kinetics[36]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[36]/Ras/GAP* /kinetics/chain/kinetics[36]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/Ras/GAP /kinetics/chain/kinetics[36]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[36]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[36]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[36]/Ras/dephosph-GAP /kinetics/chain/kinetics[36]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[35]/Ras/GAP*/diff /kinetics/chain/kinetics[36]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[36]/Ras/GAP*/diff /kinetics/chain/kinetics[36]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[36]/Ras/GAP* /kinetics/chain/kinetics[36]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/Ras/GAP* /kinetics/chain/kinetics[36]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[36]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[36]/Ras/dephosph-GAP /kinetics/chain/kinetics[36]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[36]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[36]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[35]/Ras/GAP/diff /kinetics/chain/kinetics[36]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[36]/Ras/GAP/diff /kinetics/chain/kinetics[36]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[36]/Ras/GTP-Ras /kinetics/chain/kinetics[36]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/Ras/GAP /kinetics/chain/kinetics[36]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[36]/Ras/GAP /kinetics/chain/kinetics[36]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/Ras/GAP /kinetics/chain/kinetics[36]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/Ras/inact-GEF /kinetics/chain/kinetics[36]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/Ras/CaM-GEF /kinetics/chain/kinetics[36]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca4 /kinetics/chain/kinetics[36]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[36]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[36]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[36]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[35]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[36]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[36]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[36]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[36]/Ras/GDP-Ras /kinetics/chain/kinetics[36]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/Ras/CaM-GEF /kinetics/chain/kinetics[36]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[36]/Ras/CaM-GEF /kinetics/chain/kinetics[36]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/Ras/CaM-GEF /kinetics/chain/kinetics[36]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[36]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[35]/CaM/CaM/diff /kinetics/chain/kinetics[36]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[36]/CaM/CaM/diff /kinetics/chain/kinetics[36]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[36]/CaM/CaM /kinetics/chain/kinetics[36]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/CaM/CaM /kinetics/chain/kinetics[36]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca3 /kinetics/chain/kinetics[36]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca4 /kinetics/chain/kinetics[36]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[36]/Ca /kinetics/chain/kinetics[36]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[36]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[36]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[36]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[36]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca3 /kinetics/chain/kinetics[36]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca3 /kinetics/chain/kinetics[36]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[36]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[36]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[36]/PKM/trigger_PKM /kinetics/chain/kinetics[36]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[36]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[36]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca4 /kinetics/chain/kinetics[36]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca4 /kinetics/chain/kinetics[36]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/CaM/CaM /kinetics/chain/kinetics[36]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca /kinetics/chain/kinetics[36]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[36]/Ca /kinetics/chain/kinetics[36]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[36]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[36]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[36]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[36]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca2 /kinetics/chain/kinetics[36]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca2 /kinetics/chain/kinetics[36]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca3 /kinetics/chain/kinetics[36]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca2 /kinetics/chain/kinetics[36]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/Ca /kinetics/chain/kinetics[36]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca2 /kinetics/chain/kinetics[36]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca /kinetics/chain/kinetics[36]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/Ca /kinetics/chain/kinetics[36]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[36]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[36]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[35]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[36]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[36]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca /kinetics/chain/kinetics[36]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca /kinetics/chain/kinetics[36]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[36]/Ca REAC A B addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[36]/Ca REAC A B addmsg /kinetics/chain/kinetics[36]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[36]/Ca REAC A B addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[36]/Ca REAC A B addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[36]/Ca REAC A B addmsg /kinetics/chain/kinetics[36]/Ca_diff /kinetics/chain/kinetics[36]/Ca REAC B A addmsg /kinetics/chain/kinetics[35]/Ca/diff /kinetics/chain/kinetics[36]/Ca REAC B A addmsg /kinetics/chain/kinetics[36]/Ca/diff /kinetics/chain/kinetics[36]/Ca REAC A B addmsg /kinetics/chain/kinetics[36]/Ca /kinetics/chain/kinetics[36]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/Ca /kinetics/chain/kinetics[36]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/MAPK/craf-1 /kinetics/chain/kinetics[36]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[36]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[36]/Ras/GTP-Ras /kinetics/chain/kinetics[36]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PKM/trigger_PKM /kinetics/chain/kinetics[36]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[35]/PKM/Ca_detector/diff /kinetics/chain/kinetics[36]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[36]/PKM/Ca_detector/diff /kinetics/chain/kinetics[36]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[36]/PKM/Ca_detector /kinetics/chain/kinetics[36]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PKM/Ca_detector /kinetics/chain/kinetics[36]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[36]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[36]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[36]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[36]/PKM/turn_off_activator /kinetics/chain/kinetics[36]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[35]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[36]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[36]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[36]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[36]/PKM/PKM_synthesis /kinetics/chain/kinetics[36]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[36]/PKM/AA_pool /kinetics/chain/kinetics[36]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PKM/PKM_synthesis /kinetics/chain/kinetics[36]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PKM/PKM_synthesis /kinetics/chain/kinetics[36]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[36]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[36]/PKC/PKM-zeta /kinetics/chain/kinetics[36]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PKM/degraded_PKM /kinetics/chain/kinetics[36]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[36]/PKM/PKM_degradation /kinetics/chain/kinetics[36]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[36]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[36]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[36]/PKM/trigger_PKM /kinetics/chain/kinetics[36]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[35]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[36]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[36]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[36]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[36]/PKM/Ca.detector_complex /kinetics/chain/kinetics[36]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[36]/PKM/PKM_activator /kinetics/chain/kinetics[36]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PKM/Ca.detector_complex /kinetics/chain/kinetics[36]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PKM/Ca.detector_complex /kinetics/chain/kinetics[36]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[36]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[36]/PKM/turn_off_activator /kinetics/chain/kinetics[36]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[35]/PKM/PKM_activator/diff /kinetics/chain/kinetics[36]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[36]/PKM/PKM_activator/diff /kinetics/chain/kinetics[36]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[36]/PKM/PKM_activator /kinetics/chain/kinetics[36]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PKM/PKM_activator /kinetics/chain/kinetics[36]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/PKM/PKM_synthesis /kinetics/chain/kinetics[36]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PKM/PKM_activator /kinetics/chain/kinetics[36]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca4 /kinetics/chain/kinetics[36]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PKM/Ca_detector /kinetics/chain/kinetics[36]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[36]/PKM/Ca.detector_complex /kinetics/chain/kinetics[36]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[36]/Ca_diff /kinetics/chain/kinetics[36]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[36]/Ca /kinetics/chain/kinetics[36]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[36]/Ca_input /kinetics/chain/kinetics[36]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[37]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[37]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[37]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[37]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[37]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[36]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[37]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[37]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[37]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[37]/PKC/PKC-Ca /kinetics/chain/kinetics[37]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKC/PKC-Ca /kinetics/chain/kinetics[37]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/PKC/PKC-Ca /kinetics/chain/kinetics[37]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[37]/PKC/PKC-cytosolic /kinetics/chain/kinetics[37]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/Ca /kinetics/chain/kinetics[37]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PKC/PKC-Ca /kinetics/chain/kinetics[37]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[37]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[37]/DAG /kinetics/chain/kinetics[37]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PKC/PKC-Ca /kinetics/chain/kinetics[37]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[37]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[37]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[37]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[37]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[37]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[37]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[36]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[37]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[37]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[37]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[37]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[37]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[37]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[37]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[36]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[37]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[37]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[37]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[37]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[37]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[37]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[37]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[37]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[37]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[36]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[37]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[37]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[37]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[37]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[37]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[37]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/PKC/PKC-DAG /kinetics/chain/kinetics[37]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[37]/PKC/PKC-cytosolic /kinetics/chain/kinetics[37]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/DAG /kinetics/chain/kinetics[37]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PKC/PKC-n-DAG /kinetics/chain/kinetics[37]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[36]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[37]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[37]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[37]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[37]/PKC/PKC-DAG /kinetics/chain/kinetics[37]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKC/PKC-DAG /kinetics/chain/kinetics[37]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[37]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[37]/PKC/PKC-n-DAG /kinetics/chain/kinetics[37]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[36]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[37]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[37]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[37]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[37]/PKC/PKC-cytosolic /kinetics/chain/kinetics[37]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKC/PKC-cytosolic /kinetics/chain/kinetics[37]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[37]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[37]/PKM/PKM_degradation /kinetics/chain/kinetics[37]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[36]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[37]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[37]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[37]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[37]/PKC/PKM-zeta /kinetics/chain/kinetics[37]/PKC/PKM-zeta/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKC/PKM-zeta /kinetics/chain/kinetics[37]/PKC/PKM-zeta/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[37]/DAG REAC A B addmsg /kinetics/chain/kinetics[37]/PKC/PKC-n-DAG /kinetics/chain/kinetics[37]/DAG REAC A B addmsg /kinetics/chain/kinetics[37]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[37]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[37]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[37]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[37]/PKC/PKM-zeta /kinetics/chain/kinetics[37]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[37]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[37]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[37]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[37]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[37]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[37]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[37]/PKC-active /kinetics/chain/kinetics[37]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[37]/MAPK/craf-1 /kinetics/chain/kinetics[37]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PKC-active /kinetics/chain/kinetics[37]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[37]/Ras/GAP /kinetics/chain/kinetics[37]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PKC-active /kinetics/chain/kinetics[37]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[37]/Ras/inact-GEF /kinetics/chain/kinetics[37]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[37]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[37]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[37]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[37]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[37]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[36]/MAPK*/diff /kinetics/chain/kinetics[37]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[37]/MAPK*/diff /kinetics/chain/kinetics[37]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[37]/MAPK* /kinetics/chain/kinetics[37]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[37]/MAPK/craf-1* /kinetics/chain/kinetics[37]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/MAPK* /kinetics/chain/kinetics[37]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/MAPK* /kinetics/chain/kinetics[37]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[37]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[37]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[37]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[37]/Ras-act-unphosph-raf /kinetics/chain/kinetics[37]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[36]/MAPK/craf-1/diff /kinetics/chain/kinetics[37]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[37]/MAPK/craf-1/diff /kinetics/chain/kinetics[37]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[37]/MAPK/craf-1 /kinetics/chain/kinetics[37]/MAPK/craf-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/MAPK/craf-1 /kinetics/chain/kinetics[37]/MAPK/craf-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[37]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[37]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[37]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[37]/Ras-act-craf /kinetics/chain/kinetics[37]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[37]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[37]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[37]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[37]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[36]/MAPK/craf-1*/diff /kinetics/chain/kinetics[37]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[37]/MAPK/craf-1*/diff /kinetics/chain/kinetics[37]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[37]/MAPK/craf-1* /kinetics/chain/kinetics[37]/MAPK/craf-1*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/MAPK/craf-1* /kinetics/chain/kinetics[37]/MAPK/craf-1*/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[37]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[37]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[37]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[37]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[37]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[36]/MAPK/MAPKK/diff /kinetics/chain/kinetics[37]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[37]/MAPK/MAPKK/diff /kinetics/chain/kinetics[37]/MAPK/MAPKK REAC A B addmsg /kinetics/chain/kinetics[37]/MAPK/MAPKK /kinetics/chain/kinetics[37]/MAPK/MAPKK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/MAPK/MAPKK /kinetics/chain/kinetics[37]/MAPK/MAPKK/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[37]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[37]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[37]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[36]/MAPK/MAPK/diff /kinetics/chain/kinetics[37]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[37]/MAPK/MAPK/diff /kinetics/chain/kinetics[37]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[37]/MAPK/MAPK /kinetics/chain/kinetics[37]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/MAPK/MAPK /kinetics/chain/kinetics[37]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[37]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[37]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[37]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[36]/MAPK/craf-1**/diff /kinetics/chain/kinetics[37]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[37]/MAPK/craf-1**/diff /kinetics/chain/kinetics[37]/MAPK/craf-1** REAC A B addmsg /kinetics/chain/kinetics[37]/MAPK/craf-1** /kinetics/chain/kinetics[37]/MAPK/craf-1**/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/MAPK/craf-1** /kinetics/chain/kinetics[37]/MAPK/craf-1**/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[37]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[37]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[37]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[37]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[37]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[37]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[37]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[36]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[37]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[37]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[37]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[37]/MAPK/MAPK-tyr /kinetics/chain/kinetics[37]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/MAPK/MAPK-tyr /kinetics/chain/kinetics[37]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[37]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[37]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[37]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[37]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[37]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[37]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[37]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[37]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[37]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[36]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[37]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[37]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[37]/MAPK/MAPKK* REAC A B addmsg /kinetics/chain/kinetics[37]/MAPK/MAPK /kinetics/chain/kinetics[37]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/MAPK/MAPKK* /kinetics/chain/kinetics[37]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[37]/MAPK/MAPK-tyr /kinetics/chain/kinetics[37]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/MAPK/MAPKK* /kinetics/chain/kinetics[37]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[37]/MAPK/MAPKK* /kinetics/chain/kinetics[37]/MAPK/MAPKK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/MAPK/MAPKK* /kinetics/chain/kinetics[37]/MAPK/MAPKK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[37]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[37]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[37]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[37]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[37]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[37]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[37]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[37]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[37]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[37]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[37]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[36]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[37]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[37]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[37]/MAPK/MAPKK-ser REAC A B addmsg /kinetics/chain/kinetics[37]/MAPK/MAPKK-ser /kinetics/chain/kinetics[37]/MAPK/MAPKK-ser/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/MAPK/MAPKK-ser /kinetics/chain/kinetics[37]/MAPK/MAPKK-ser/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[37]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[37]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[37]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[37]/Ras-act-unphosph-raf /kinetics/chain/kinetics[37]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[36]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[37]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[37]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[37]/MAPK/Raf-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[37]/MAPK/MAPKK /kinetics/chain/kinetics[37]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[37]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[37]/MAPK/MAPKK-ser /kinetics/chain/kinetics[37]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[37]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[37]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[37]/MAPK/Raf-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[37]/MAPK/Raf-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[37]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[37]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[37]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[37]/Ras-act-craf /kinetics/chain/kinetics[37]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[36]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[37]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[37]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[37]/MAPK/Raf*-GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[37]/MAPK/MAPKK /kinetics/chain/kinetics[37]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[37]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[37]/MAPK/MAPKK-ser /kinetics/chain/kinetics[37]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[37]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[37]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[37]/MAPK/Raf*-GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[37]/MAPK/Raf*-GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[37]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[37]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[37]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[36]/MKP-1/diff /kinetics/chain/kinetics[37]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[37]/MKP-1/diff /kinetics/chain/kinetics[37]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[37]/MAPK/MAPK-tyr /kinetics/chain/kinetics[37]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/MKP-1 /kinetics/chain/kinetics[37]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[37]/MAPK* /kinetics/chain/kinetics[37]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/MKP-1 /kinetics/chain/kinetics[37]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[37]/MKP-1 /kinetics/chain/kinetics[37]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/MKP-1 /kinetics/chain/kinetics[37]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/MAPK/craf-1* /kinetics/chain/kinetics[37]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[37]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[37]/Ras/GTP-Ras /kinetics/chain/kinetics[37]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[37]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[37]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[37]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[37]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[37]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[37]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[37]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[36]/PPhosphatase2A/diff /kinetics/chain/kinetics[37]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[37]/PPhosphatase2A/diff /kinetics/chain/kinetics[37]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[37]/MAPK/craf-1* /kinetics/chain/kinetics[37]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PPhosphatase2A /kinetics/chain/kinetics[37]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[37]/MAPK/MAPKK* /kinetics/chain/kinetics[37]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PPhosphatase2A /kinetics/chain/kinetics[37]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[37]/MAPK/MAPKK-ser /kinetics/chain/kinetics[37]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PPhosphatase2A /kinetics/chain/kinetics[37]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[37]/MAPK/craf-1** /kinetics/chain/kinetics[37]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PPhosphatase2A /kinetics/chain/kinetics[37]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[37]/PPhosphatase2A /kinetics/chain/kinetics[37]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PPhosphatase2A /kinetics/chain/kinetics[37]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/Ras/inact-GEF /kinetics/chain/kinetics[37]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[37]/Ras/GEF* /kinetics/chain/kinetics[37]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[37]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[37]/Ras/dephosph-GEF /kinetics/chain/kinetics[37]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[37]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[37]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[37]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[37]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[36]/Ras/inact-GEF/diff /kinetics/chain/kinetics[37]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[37]/Ras/inact-GEF/diff /kinetics/chain/kinetics[37]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[37]/Ras/inact-GEF /kinetics/chain/kinetics[37]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[37]/Ras/GDP-Ras /kinetics/chain/kinetics[37]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/Ras/inact-GEF /kinetics/chain/kinetics[37]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/Ras/inact-GEF /kinetics/chain/kinetics[37]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[37]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[37]/Ras/dephosph-GEF /kinetics/chain/kinetics[37]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[37]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[37]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[36]/Ras/GEF*/diff /kinetics/chain/kinetics[37]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[37]/Ras/GEF*/diff /kinetics/chain/kinetics[37]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[37]/Ras/GEF* /kinetics/chain/kinetics[37]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[37]/Ras/GDP-Ras /kinetics/chain/kinetics[37]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/Ras/GEF* /kinetics/chain/kinetics[37]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/Ras/GEF* /kinetics/chain/kinetics[37]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/Ras-act-craf /kinetics/chain/kinetics[37]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[37]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[37]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[37]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[37]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[37]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[37]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[37]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[37]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[37]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[37]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[37]/Ras-act-unphosph-raf /kinetics/chain/kinetics[37]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[36]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[37]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[37]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[37]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[37]/Ras/GTP-Ras /kinetics/chain/kinetics[37]/Ras/GTP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/Ras/GTP-Ras /kinetics/chain/kinetics[37]/Ras/GTP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[37]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[37]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[37]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[37]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[37]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[37]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[37]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[37]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[37]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[36]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[37]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[37]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[37]/Ras/GDP-Ras REAC A B addmsg /kinetics/chain/kinetics[37]/Ras/GDP-Ras /kinetics/chain/kinetics[37]/Ras/GDP-Ras/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/Ras/GDP-Ras /kinetics/chain/kinetics[37]/Ras/GDP-Ras/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/Ras/GTP-Ras /kinetics/chain/kinetics[37]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/Ras/GDP-Ras /kinetics/chain/kinetics[37]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[37]/Ras/GAP* /kinetics/chain/kinetics[37]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/Ras/GAP /kinetics/chain/kinetics[37]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[37]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[37]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[37]/Ras/dephosph-GAP /kinetics/chain/kinetics[37]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[36]/Ras/GAP*/diff /kinetics/chain/kinetics[37]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[37]/Ras/GAP*/diff /kinetics/chain/kinetics[37]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[37]/Ras/GAP* /kinetics/chain/kinetics[37]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/Ras/GAP* /kinetics/chain/kinetics[37]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[37]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[37]/Ras/dephosph-GAP /kinetics/chain/kinetics[37]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[37]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[37]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[36]/Ras/GAP/diff /kinetics/chain/kinetics[37]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[37]/Ras/GAP/diff /kinetics/chain/kinetics[37]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[37]/Ras/GTP-Ras /kinetics/chain/kinetics[37]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/Ras/GAP /kinetics/chain/kinetics[37]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[37]/Ras/GAP /kinetics/chain/kinetics[37]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/Ras/GAP /kinetics/chain/kinetics[37]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/Ras/inact-GEF /kinetics/chain/kinetics[37]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/Ras/CaM-GEF /kinetics/chain/kinetics[37]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca4 /kinetics/chain/kinetics[37]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[37]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[37]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[37]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[36]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[37]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[37]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[37]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[37]/Ras/GDP-Ras /kinetics/chain/kinetics[37]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/Ras/CaM-GEF /kinetics/chain/kinetics[37]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[37]/Ras/CaM-GEF /kinetics/chain/kinetics[37]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/Ras/CaM-GEF /kinetics/chain/kinetics[37]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[37]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[36]/CaM/CaM/diff /kinetics/chain/kinetics[37]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[37]/CaM/CaM/diff /kinetics/chain/kinetics[37]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[37]/CaM/CaM /kinetics/chain/kinetics[37]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/CaM/CaM /kinetics/chain/kinetics[37]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca3 /kinetics/chain/kinetics[37]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca4 /kinetics/chain/kinetics[37]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[37]/Ca /kinetics/chain/kinetics[37]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[37]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[37]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[37]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[37]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca3 /kinetics/chain/kinetics[37]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/CaM/CaM-Ca3 /kinetics/chain/kinetics[37]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[37]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[37]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[37]/PKM/trigger_PKM /kinetics/chain/kinetics[37]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[37]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[37]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca4 /kinetics/chain/kinetics[37]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/CaM/CaM-Ca4 /kinetics/chain/kinetics[37]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/CaM/CaM /kinetics/chain/kinetics[37]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca /kinetics/chain/kinetics[37]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[37]/Ca /kinetics/chain/kinetics[37]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[37]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[37]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[37]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[37]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca2 /kinetics/chain/kinetics[37]/CaM/CaM-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/CaM/CaM-Ca2 /kinetics/chain/kinetics[37]/CaM/CaM-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca3 /kinetics/chain/kinetics[37]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca2 /kinetics/chain/kinetics[37]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/Ca /kinetics/chain/kinetics[37]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca2 /kinetics/chain/kinetics[37]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca /kinetics/chain/kinetics[37]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/Ca /kinetics/chain/kinetics[37]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[37]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[37]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[36]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[37]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[37]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca /kinetics/chain/kinetics[37]/CaM/CaM-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/CaM/CaM-Ca /kinetics/chain/kinetics[37]/CaM/CaM-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[37]/Ca REAC A B addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[37]/Ca REAC A B addmsg /kinetics/chain/kinetics[37]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[37]/Ca REAC A B addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[37]/Ca REAC A B addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[37]/Ca REAC A B addmsg /kinetics/chain/kinetics[37]/Ca_diff /kinetics/chain/kinetics[37]/Ca REAC B A addmsg /kinetics/chain/kinetics[36]/Ca/diff /kinetics/chain/kinetics[37]/Ca REAC B A addmsg /kinetics/chain/kinetics[37]/Ca/diff /kinetics/chain/kinetics[37]/Ca REAC A B addmsg /kinetics/chain/kinetics[37]/Ca /kinetics/chain/kinetics[37]/Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/Ca /kinetics/chain/kinetics[37]/Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/MAPK/craf-1 /kinetics/chain/kinetics[37]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[37]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[37]/Ras/GTP-Ras /kinetics/chain/kinetics[37]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PKM/trigger_PKM /kinetics/chain/kinetics[37]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[36]/PKM/Ca_detector/diff /kinetics/chain/kinetics[37]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[37]/PKM/Ca_detector/diff /kinetics/chain/kinetics[37]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[37]/PKM/Ca_detector /kinetics/chain/kinetics[37]/PKM/Ca_detector/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKM/Ca_detector /kinetics/chain/kinetics[37]/PKM/Ca_detector/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[37]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[37]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[37]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[37]/PKM/turn_off_activator /kinetics/chain/kinetics[37]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[36]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[37]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[37]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[37]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[37]/PKM/PKM_synthesis /kinetics/chain/kinetics[37]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[37]/PKM/AA_pool /kinetics/chain/kinetics[37]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PKM/PKM_synthesis /kinetics/chain/kinetics[37]/PKM/PKM_synthesis/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKM/PKM_synthesis /kinetics/chain/kinetics[37]/PKM/PKM_synthesis/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[37]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[37]/PKC/PKM-zeta /kinetics/chain/kinetics[37]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PKM/degraded_PKM /kinetics/chain/kinetics[37]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[37]/PKM/PKM_degradation /kinetics/chain/kinetics[37]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[37]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[37]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[37]/PKM/trigger_PKM /kinetics/chain/kinetics[37]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[36]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[37]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[37]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[37]/PKM/Ca.detector_complex REAC A B addmsg /kinetics/chain/kinetics[37]/PKM/Ca.detector_complex /kinetics/chain/kinetics[37]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[37]/PKM/PKM_activator /kinetics/chain/kinetics[37]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PKM/Ca.detector_complex /kinetics/chain/kinetics[37]/PKM/Ca.detector_complex/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKM/Ca.detector_complex /kinetics/chain/kinetics[37]/PKM/Ca.detector_complex/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[37]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[37]/PKM/turn_off_activator /kinetics/chain/kinetics[37]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[36]/PKM/PKM_activator/diff /kinetics/chain/kinetics[37]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[37]/PKM/PKM_activator/diff /kinetics/chain/kinetics[37]/PKM/PKM_activator REAC A B addmsg /kinetics/chain/kinetics[37]/PKM/PKM_activator /kinetics/chain/kinetics[37]/PKM/PKM_activator/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKM/PKM_activator /kinetics/chain/kinetics[37]/PKM/PKM_activator/diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/PKM/PKM_synthesis /kinetics/chain/kinetics[37]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PKM/PKM_activator /kinetics/chain/kinetics[37]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca4 /kinetics/chain/kinetics[37]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PKM/Ca_detector /kinetics/chain/kinetics[37]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[37]/PKM/Ca.detector_complex /kinetics/chain/kinetics[37]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[37]/Ca_diff /kinetics/chain/kinetics[37]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[37]/Ca /kinetics/chain/kinetics[37]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[37]/Ca_input /kinetics/chain/kinetics[37]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[38]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[38]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[38]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[38]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[38]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[37]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[38]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[38]/PKC/PKC-Ca /kinetics/chain/kinetics[38]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[38]/PKC/PKC-cytosolic /kinetics/chain/kinetics[38]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/Ca /kinetics/chain/kinetics[38]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKC/PKC-Ca /kinetics/chain/kinetics[38]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[38]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[38]/DAG /kinetics/chain/kinetics[38]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKC/PKC-Ca /kinetics/chain/kinetics[38]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[38]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[38]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[38]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[38]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[38]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[38]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[37]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[38]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[38]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[38]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[37]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[38]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[38]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[38]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[38]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[38]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[37]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[38]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[38]/PKC/PKC-DAG /kinetics/chain/kinetics[38]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[38]/PKC/PKC-cytosolic /kinetics/chain/kinetics[38]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/DAG /kinetics/chain/kinetics[38]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKC/PKC-n-DAG /kinetics/chain/kinetics[38]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[37]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[38]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[38]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[38]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[38]/PKC/PKC-n-DAG /kinetics/chain/kinetics[38]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[37]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[38]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[38]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[38]/PKC/PKM-zeta MM_PRD pA addmsg /kinetics/chain/kinetics[38]/PKM/PKM_degradation /kinetics/chain/kinetics[38]/PKC/PKM-zeta REAC A B addmsg /kinetics/chain/kinetics[37]/PKC/PKM-zeta/diff /kinetics/chain/kinetics[38]/PKC/PKM-zeta REAC B A addmsg /kinetics/chain/kinetics[38]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[38]/DAG REAC A B addmsg /kinetics/chain/kinetics[38]/PKC/PKC-n-DAG /kinetics/chain/kinetics[38]/DAG REAC A B addmsg /kinetics/chain/kinetics[38]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[38]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[38]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[38]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[38]/PKC/PKM-zeta /kinetics/chain/kinetics[38]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[38]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[38]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[38]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[38]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[38]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[38]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[38]/PKC-active /kinetics/chain/kinetics[38]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[38]/MAPK/craf-1 /kinetics/chain/kinetics[38]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKC-active /kinetics/chain/kinetics[38]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[38]/Ras/GAP /kinetics/chain/kinetics[38]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKC-active /kinetics/chain/kinetics[38]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[38]/Ras/inact-GEF /kinetics/chain/kinetics[38]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[38]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[38]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[38]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[38]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[38]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[37]/MAPK*/diff /kinetics/chain/kinetics[38]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[38]/MAPK* /kinetics/chain/kinetics[38]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[38]/MAPK/craf-1* /kinetics/chain/kinetics[38]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[38]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[38]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[38]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[38]/Ras-act-unphosph-raf /kinetics/chain/kinetics[38]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[37]/MAPK/craf-1/diff /kinetics/chain/kinetics[38]/MAPK/craf-1 REAC B A addmsg /kinetics/chain/kinetics[38]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[38]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[38]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[38]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[38]/Ras-act-craf /kinetics/chain/kinetics[38]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[38]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[38]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[38]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[38]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[37]/MAPK/craf-1*/diff /kinetics/chain/kinetics[38]/MAPK/craf-1* REAC B A addmsg /kinetics/chain/kinetics[38]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[38]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[38]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[38]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[38]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[38]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[37]/MAPK/MAPKK/diff /kinetics/chain/kinetics[38]/MAPK/MAPKK REAC B A addmsg /kinetics/chain/kinetics[38]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[38]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[38]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[38]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[37]/MAPK/MAPK/diff /kinetics/chain/kinetics[38]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[38]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[38]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[38]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[38]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[37]/MAPK/craf-1**/diff /kinetics/chain/kinetics[38]/MAPK/craf-1** REAC B A addmsg /kinetics/chain/kinetics[38]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[38]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[38]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[38]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[38]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[38]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[38]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[38]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[37]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[38]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[38]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[38]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[38]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[38]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[38]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[38]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[38]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[38]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[38]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[38]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[37]/MAPK/MAPKK*/diff /kinetics/chain/kinetics[38]/MAPK/MAPKK* REAC B A addmsg /kinetics/chain/kinetics[38]/MAPK/MAPK /kinetics/chain/kinetics[38]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/MAPK/MAPKK* /kinetics/chain/kinetics[38]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[38]/MAPK/MAPK-tyr /kinetics/chain/kinetics[38]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/MAPK/MAPKK* /kinetics/chain/kinetics[38]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[38]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[38]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[38]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[38]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[38]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[38]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[38]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[38]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[38]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[38]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[38]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[38]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[37]/MAPK/MAPKK-ser/diff /kinetics/chain/kinetics[38]/MAPK/MAPKK-ser REAC B A addmsg /kinetics/chain/kinetics[38]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[38]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[38]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[38]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[38]/Ras-act-unphosph-raf /kinetics/chain/kinetics[38]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[37]/MAPK/Raf-GTP-Ras/diff /kinetics/chain/kinetics[38]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[38]/MAPK/MAPKK /kinetics/chain/kinetics[38]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[38]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[38]/MAPK/MAPKK-ser /kinetics/chain/kinetics[38]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[38]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[38]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[38]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[38]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[38]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[38]/Ras-act-craf /kinetics/chain/kinetics[38]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[37]/MAPK/Raf*-GTP-Ras/diff /kinetics/chain/kinetics[38]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[38]/MAPK/MAPKK /kinetics/chain/kinetics[38]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[38]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[38]/MAPK/MAPKK-ser /kinetics/chain/kinetics[38]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[38]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[38]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[38]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[38]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[38]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[37]/MKP-1/diff /kinetics/chain/kinetics[38]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[38]/MAPK/MAPK-tyr /kinetics/chain/kinetics[38]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/MKP-1 /kinetics/chain/kinetics[38]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[38]/MAPK* /kinetics/chain/kinetics[38]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/MKP-1 /kinetics/chain/kinetics[38]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[38]/MAPK/craf-1* /kinetics/chain/kinetics[38]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[38]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[38]/Ras/GTP-Ras /kinetics/chain/kinetics[38]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[38]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[38]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[38]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[38]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[38]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[38]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[38]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[37]/PPhosphatase2A/diff /kinetics/chain/kinetics[38]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[38]/MAPK/craf-1* /kinetics/chain/kinetics[38]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PPhosphatase2A /kinetics/chain/kinetics[38]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[38]/MAPK/MAPKK* /kinetics/chain/kinetics[38]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PPhosphatase2A /kinetics/chain/kinetics[38]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[38]/MAPK/MAPKK-ser /kinetics/chain/kinetics[38]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PPhosphatase2A /kinetics/chain/kinetics[38]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[38]/MAPK/craf-1** /kinetics/chain/kinetics[38]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PPhosphatase2A /kinetics/chain/kinetics[38]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[38]/Ras/inact-GEF /kinetics/chain/kinetics[38]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[38]/Ras/GEF* /kinetics/chain/kinetics[38]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[38]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[38]/Ras/dephosph-GEF /kinetics/chain/kinetics[38]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[38]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[38]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[38]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[38]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[37]/Ras/inact-GEF/diff /kinetics/chain/kinetics[38]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[38]/Ras/inact-GEF /kinetics/chain/kinetics[38]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[38]/Ras/GDP-Ras /kinetics/chain/kinetics[38]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[38]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[38]/Ras/dephosph-GEF /kinetics/chain/kinetics[38]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[38]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[38]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[37]/Ras/GEF*/diff /kinetics/chain/kinetics[38]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[38]/Ras/GEF* /kinetics/chain/kinetics[38]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[38]/Ras/GDP-Ras /kinetics/chain/kinetics[38]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/Ras-act-craf /kinetics/chain/kinetics[38]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[38]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[38]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[38]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[38]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[38]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[38]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[38]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[38]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[38]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[38]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[38]/Ras-act-unphosph-raf /kinetics/chain/kinetics[38]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[37]/Ras/GTP-Ras/diff /kinetics/chain/kinetics[38]/Ras/GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[38]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[38]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[38]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[38]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[38]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[38]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[38]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[38]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[38]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[38]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[37]/Ras/GDP-Ras/diff /kinetics/chain/kinetics[38]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[38]/Ras/GTP-Ras /kinetics/chain/kinetics[38]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/Ras/GDP-Ras /kinetics/chain/kinetics[38]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[38]/Ras/GAP* /kinetics/chain/kinetics[38]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/Ras/GAP /kinetics/chain/kinetics[38]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[38]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[38]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[38]/Ras/dephosph-GAP /kinetics/chain/kinetics[38]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[37]/Ras/GAP*/diff /kinetics/chain/kinetics[38]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[38]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[38]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[38]/Ras/dephosph-GAP /kinetics/chain/kinetics[38]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[38]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[38]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[37]/Ras/GAP/diff /kinetics/chain/kinetics[38]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[38]/Ras/GTP-Ras /kinetics/chain/kinetics[38]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/Ras/GAP /kinetics/chain/kinetics[38]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[38]/Ras/inact-GEF /kinetics/chain/kinetics[38]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/Ras/CaM-GEF /kinetics/chain/kinetics[38]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[38]/CaM/CaM-Ca4 /kinetics/chain/kinetics[38]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[38]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[38]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[38]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[37]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[38]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[38]/Ras/GDP-Ras /kinetics/chain/kinetics[38]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/Ras/CaM-GEF /kinetics/chain/kinetics[38]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[38]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[38]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[37]/CaM/CaM/diff /kinetics/chain/kinetics[38]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[38]/CaM/CaM-Ca3 /kinetics/chain/kinetics[38]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/CaM/CaM-Ca4 /kinetics/chain/kinetics[38]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[38]/Ca /kinetics/chain/kinetics[38]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[38]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[38]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[38]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[38]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[38]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[38]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[38]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[38]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[38]/PKM/trigger_PKM /kinetics/chain/kinetics[38]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[38]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[38]/CaM/CaM /kinetics/chain/kinetics[38]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/CaM/CaM-Ca /kinetics/chain/kinetics[38]/CaM/CaM-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[38]/Ca /kinetics/chain/kinetics[38]/CaM/CaM-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[38]/CaM/CaM-Ca2 REAC A B addmsg /kinetics/chain/kinetics[38]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[38]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca2/diff /kinetics/chain/kinetics[38]/CaM/CaM-Ca2 REAC B A addmsg /kinetics/chain/kinetics[38]/CaM/CaM-Ca3 /kinetics/chain/kinetics[38]/CaM/CaM-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[38]/CaM/CaM-Ca2 /kinetics/chain/kinetics[38]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/Ca /kinetics/chain/kinetics[38]/CaM/CaM-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/CaM/CaM-Ca2 /kinetics/chain/kinetics[38]/CaM/CaM-Ca-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[38]/CaM/CaM-Ca /kinetics/chain/kinetics[38]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/Ca /kinetics/chain/kinetics[38]/CaM/CaM-Ca-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[38]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[38]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[38]/CaM/CaM-Ca REAC A B addmsg /kinetics/chain/kinetics[37]/CaM/CaM-Ca/diff /kinetics/chain/kinetics[38]/CaM/CaM-Ca REAC B A addmsg /kinetics/chain/kinetics[38]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[38]/Ca REAC A B addmsg /kinetics/chain/kinetics[38]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[38]/Ca REAC A B addmsg /kinetics/chain/kinetics[38]/CaM/CaM-bind-Ca /kinetics/chain/kinetics[38]/Ca REAC A B addmsg /kinetics/chain/kinetics[38]/CaM/CaM-Ca2-bind-Ca /kinetics/chain/kinetics[38]/Ca REAC A B addmsg /kinetics/chain/kinetics[38]/CaM/CaM-Ca-bind-Ca /kinetics/chain/kinetics[38]/Ca REAC A B addmsg /kinetics/chain/kinetics[38]/Ca_diff /kinetics/chain/kinetics[38]/Ca REAC B A addmsg /kinetics/chain/kinetics[37]/Ca/diff /kinetics/chain/kinetics[38]/Ca REAC B A addmsg /kinetics/chain/kinetics[38]/MAPK/craf-1 /kinetics/chain/kinetics[38]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[38]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[38]/Ras/GTP-Ras /kinetics/chain/kinetics[38]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKM/trigger_PKM /kinetics/chain/kinetics[38]/PKM/Ca_detector REAC A B addmsg /kinetics/chain/kinetics[37]/PKM/Ca_detector/diff /kinetics/chain/kinetics[38]/PKM/Ca_detector REAC B A addmsg /kinetics/chain/kinetics[38]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[38]/PKM/PKM_synthesis REAC eA B addmsg /kinetics/chain/kinetics[38]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[38]/PKM/PKM_synthesis MM_PRD pA addmsg /kinetics/chain/kinetics[38]/PKM/turn_off_activator /kinetics/chain/kinetics[38]/PKM/PKM_synthesis REAC A B addmsg /kinetics/chain/kinetics[37]/PKM/PKM_synthesis/diff /kinetics/chain/kinetics[38]/PKM/PKM_synthesis REAC B A addmsg /kinetics/chain/kinetics[38]/PKM/PKM_synthesis /kinetics/chain/kinetics[38]/PKM/PKM_synthesis/kenz ENZYME n addmsg /kinetics/chain/kinetics[38]/PKM/AA_pool /kinetics/chain/kinetics[38]/PKM/PKM_synthesis/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKM/PKM_synthesis/kenz /kinetics/chain/kinetics[38]/PKM/AA_pool REAC sA B addmsg /kinetics/chain/kinetics[38]/PKC/PKM-zeta /kinetics/chain/kinetics[38]/PKM/PKM_degradation SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKM/degraded_PKM /kinetics/chain/kinetics[38]/PKM/PKM_degradation PRODUCT n addmsg /kinetics/chain/kinetics[38]/PKM/PKM_degradation /kinetics/chain/kinetics[38]/PKM/degraded_PKM REAC B A addmsg /kinetics/chain/kinetics[38]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[38]/PKM/Ca.detector_complex REAC eA B addmsg /kinetics/chain/kinetics[38]/PKM/trigger_PKM /kinetics/chain/kinetics[38]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[37]/PKM/Ca.detector_complex/diff /kinetics/chain/kinetics[38]/PKM/Ca.detector_complex REAC B A addmsg /kinetics/chain/kinetics[38]/PKM/Ca.detector_complex /kinetics/chain/kinetics[38]/PKM/Ca.detector_complex/kenz ENZYME n addmsg /kinetics/chain/kinetics[38]/PKM/PKM_activator /kinetics/chain/kinetics[38]/PKM/Ca.detector_complex/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKM/Ca.detector_complex/kenz /kinetics/chain/kinetics[38]/PKM/PKM_activator REAC sA B addmsg /kinetics/chain/kinetics[38]/PKM/turn_off_activator /kinetics/chain/kinetics[38]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[37]/PKM/PKM_activator/diff /kinetics/chain/kinetics[38]/PKM/PKM_activator REAC B A addmsg /kinetics/chain/kinetics[38]/PKM/PKM_synthesis /kinetics/chain/kinetics[38]/PKM/turn_off_activator SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKM/PKM_activator /kinetics/chain/kinetics[38]/PKM/turn_off_activator PRODUCT n addmsg /kinetics/chain/kinetics[38]/CaM/CaM-Ca4 /kinetics/chain/kinetics[38]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKM/Ca_detector /kinetics/chain/kinetics[38]/PKM/trigger_PKM SUBSTRATE n addmsg /kinetics/chain/kinetics[38]/PKM/Ca.detector_complex /kinetics/chain/kinetics[38]/PKM/trigger_PKM PRODUCT n addmsg /kinetics/chain/kinetics[38]/Ca_diff /kinetics/chain/kinetics[38]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[38]/Ca /kinetics/chain/kinetics[38]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[38]/Ca_input /kinetics/chain/kinetics[38]/Ca_diff SUBSTRATE n enddump // End of dump call /kinetics/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[1]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[1]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[1]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[1]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[1]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[1]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[1]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[1]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[1]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[1]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[1]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[1]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[1]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[1]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[1]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[1]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[1]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[1]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[1]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[1]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[1]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[1]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[1]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[1]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[1]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[1]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[1]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[1]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[1]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[1]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[1]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[1]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[1]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[1]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[1]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[1]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[1]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[1]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[1]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[1]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[1]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[1]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[2]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[2]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[2]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[2]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[2]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[2]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[2]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[2]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[2]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[2]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[2]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[2]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[2]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[2]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[2]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[2]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[2]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[2]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[2]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[2]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[2]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[2]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[2]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[2]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[2]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[2]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[2]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[2]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[2]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[2]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[2]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[2]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[2]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[2]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[2]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[2]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[2]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[2]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[2]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[2]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[2]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[2]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[3]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[3]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[3]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[3]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[3]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[3]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[3]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[3]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[3]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[3]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[3]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[3]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[3]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[3]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[3]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[3]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[3]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[3]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[3]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[3]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[3]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[3]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[3]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[3]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[3]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[3]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[3]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[3]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[3]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[3]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[3]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[3]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[3]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[3]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[3]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[3]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[3]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[3]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[3]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[3]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[3]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[3]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[4]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[4]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[4]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[4]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[4]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[4]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[4]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[4]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[4]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[4]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[4]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[4]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[4]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[4]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[4]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[4]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[4]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[4]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[4]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[4]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[4]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[4]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[4]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[4]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[4]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[4]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[4]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[4]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[4]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[4]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[4]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[4]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[4]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[4]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[4]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[4]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[4]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[4]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[4]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[4]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[4]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[4]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[5]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[5]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[5]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[5]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[5]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[5]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[5]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[5]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[5]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[5]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[5]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[5]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[5]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[5]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[5]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[5]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[5]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[5]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[5]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[5]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[5]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[5]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[5]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[5]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[5]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[5]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[5]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[5]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[5]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[5]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[5]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[5]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[5]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[5]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[5]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[5]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[5]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[5]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[5]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[5]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[5]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[5]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[6]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[6]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[6]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[6]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[6]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[6]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[6]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[6]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[6]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[6]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[6]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[6]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[6]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[6]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[6]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[6]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[6]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[6]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[6]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[6]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[6]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[6]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[6]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[6]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[6]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[6]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[6]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[6]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[6]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[6]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[6]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[6]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[6]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[6]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[6]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[6]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[6]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[6]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[6]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[6]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[6]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[6]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[7]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[7]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[7]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[7]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[7]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[7]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[7]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[7]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[7]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[7]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[7]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[7]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[7]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[7]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[7]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[7]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[7]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[7]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[7]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[7]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[7]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[7]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[7]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[7]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[7]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[7]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[7]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[7]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[7]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[7]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[7]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[7]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[7]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[7]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[7]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[7]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[7]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[7]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[7]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[7]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[7]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[7]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[8]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[8]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[8]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[8]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[8]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[8]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[8]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[8]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[8]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[8]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[8]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[8]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[8]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[8]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[8]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[8]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[8]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[8]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[8]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[8]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[8]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[8]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[8]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[8]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[8]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[8]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[8]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[8]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[8]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[8]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[8]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[8]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[8]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[8]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[8]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[8]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[8]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[8]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[8]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[8]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[8]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[8]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[9]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[9]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[9]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[9]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[9]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[9]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[9]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[9]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[9]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[9]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[9]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[9]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[9]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[9]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[9]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[9]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[9]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[9]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[9]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[9]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[9]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[9]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[9]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[9]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[9]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[9]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[9]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[9]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[9]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[9]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[9]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[9]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[9]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[9]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[9]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[9]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[9]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[9]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[9]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[9]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[9]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[9]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[10]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[10]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[10]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[10]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[10]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[10]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[10]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[10]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[10]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[10]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[10]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[10]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[10]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[10]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[10]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[10]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[10]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[10]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[10]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[10]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[10]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[10]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[10]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[10]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[10]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[10]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[10]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[10]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[10]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[10]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[10]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[10]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[10]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[10]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[10]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[10]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[10]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[10]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[10]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[10]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[10]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[10]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[11]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[11]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[11]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[11]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[11]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[11]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[11]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[11]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[11]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[11]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[11]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[11]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[11]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[11]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[11]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[11]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[11]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[11]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[11]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[11]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[11]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[11]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[11]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[11]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[11]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[11]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[11]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[11]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[11]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[11]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[11]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[11]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[11]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[11]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[11]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[11]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[11]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[11]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[11]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[11]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[11]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[11]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[12]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[12]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[12]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[12]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[12]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[12]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[12]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[12]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[12]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[12]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[12]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[12]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[12]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[12]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[12]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[12]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[12]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[12]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[12]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[12]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[12]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[12]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[12]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[12]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[12]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[12]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[12]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[12]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[12]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[12]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[12]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[12]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[12]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[12]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[12]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[12]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[12]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[12]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[12]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[12]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[12]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[12]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[13]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[13]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[13]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[13]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[13]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[13]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[13]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[13]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[13]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[13]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[13]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[13]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[13]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[13]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[13]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[13]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[13]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[13]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[13]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[13]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[13]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[13]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[13]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[13]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[13]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[13]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[13]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[13]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[13]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[13]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[13]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[13]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[13]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[13]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[13]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[13]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[13]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[13]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[13]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[13]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[13]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[13]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[14]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[14]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[14]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[14]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[14]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[14]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[14]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[14]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[14]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[14]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[14]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[14]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[14]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[14]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[14]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[14]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[14]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[14]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[14]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[14]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[14]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[14]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[14]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[14]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[14]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[14]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[14]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[14]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[14]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[14]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[14]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[14]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[14]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[14]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[14]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[14]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[14]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[14]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[14]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[14]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[14]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[14]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[15]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[15]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[15]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[15]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[15]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[15]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[15]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[15]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[15]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[15]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[15]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[15]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[15]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[15]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[15]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[15]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[15]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[15]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[15]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[15]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[15]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[15]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[15]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[15]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[15]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[15]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[15]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[15]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[15]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[15]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[15]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[15]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[15]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[15]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[15]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[15]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[15]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[15]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[15]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[15]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[15]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[15]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[16]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[16]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[16]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[16]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[16]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[16]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[16]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[16]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[16]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[16]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[16]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[16]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[16]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[16]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[16]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[16]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[16]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[16]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[16]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[16]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[16]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[16]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[16]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[16]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[16]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[16]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[16]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[16]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[16]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[16]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[16]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[16]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[16]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[16]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[16]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[16]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[16]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[16]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[16]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[16]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[16]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[16]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[17]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[17]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[17]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[17]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[17]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[17]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[17]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[17]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[17]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[17]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[17]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[17]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[17]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[17]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[17]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[17]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[17]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[17]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[17]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[17]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[17]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[17]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[17]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[17]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[17]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[17]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[17]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[17]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[17]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[17]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[17]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[17]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[17]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[17]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[17]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[17]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[17]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[17]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[17]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[17]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[17]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[17]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[18]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[18]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[18]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[18]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[18]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[18]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[18]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[18]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[18]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[18]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[18]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[18]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[18]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[18]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[18]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[18]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[18]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[18]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[18]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[18]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[18]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[18]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[18]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[18]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[18]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[18]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[18]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[18]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[18]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[18]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[18]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[18]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[18]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[18]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[18]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[18]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[18]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[18]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[18]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[18]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[18]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[18]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[19]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[19]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[19]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[19]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[19]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[19]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[19]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[19]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[19]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[19]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[19]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[19]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[19]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[19]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[19]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[19]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[19]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[19]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[19]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[19]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[19]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[19]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[19]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[19]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[19]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[19]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[19]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[19]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[19]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[19]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[19]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[19]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[19]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[19]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[19]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[19]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[19]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[19]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[19]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[19]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[19]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[19]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[20]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[20]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[20]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[20]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[20]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[20]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[20]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[20]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[20]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[20]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[20]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[20]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[20]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[20]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[20]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[20]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[20]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[20]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[20]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[20]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[20]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[20]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[20]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[20]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[20]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[20]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[20]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[20]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[20]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[20]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[20]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[20]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[20]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[20]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[20]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[20]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[20]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[20]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[20]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[20]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[20]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[21]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[21]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[21]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[21]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[21]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[21]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[21]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[21]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[21]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[21]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[21]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[21]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[21]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[21]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[21]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[21]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[21]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[21]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[21]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[21]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[21]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[21]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[21]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[21]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[21]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[21]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[21]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[21]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[21]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[21]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[21]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[21]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[21]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[21]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[21]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[21]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[21]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[21]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[21]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[21]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[21]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[21]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[22]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[22]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[22]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[22]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[22]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[22]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[22]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[22]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[22]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[22]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[22]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[22]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[22]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[22]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[22]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[22]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[22]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[22]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[22]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[22]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[22]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[22]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[22]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[22]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[22]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[22]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[22]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[22]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[22]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[22]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[22]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[22]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[22]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[22]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[22]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[22]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[22]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[22]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[22]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[22]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[22]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[22]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[23]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[23]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[23]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[23]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[23]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[23]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[23]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[23]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[23]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[23]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[23]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[23]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[23]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[23]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[23]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[23]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[23]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[23]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[23]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[23]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[23]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[23]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[23]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[23]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[23]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[23]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[23]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[23]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[23]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[23]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[23]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[23]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[23]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[23]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[23]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[23]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[23]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[23]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[23]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[23]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[23]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[23]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[24]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[24]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[24]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[24]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[24]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[24]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[24]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[24]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[24]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[24]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[24]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[24]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[24]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[24]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[24]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[24]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[24]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[24]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[24]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[24]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[24]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[24]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[24]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[24]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[24]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[24]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[24]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[24]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[24]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[24]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[24]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[24]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[24]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[24]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[24]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[24]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[24]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[24]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[24]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[24]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[24]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[24]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[24]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[24]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[24]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[24]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[24]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[24]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[24]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[24]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[24]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[24]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[24]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[24]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[25]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[25]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[25]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[25]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[25]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[25]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[25]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[25]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[25]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[25]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[25]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[25]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[25]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[25]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[25]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[25]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[25]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[25]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[25]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[25]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[25]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[25]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[25]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[25]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[25]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[25]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[25]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[25]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[25]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[25]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[25]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[25]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[25]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[25]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[25]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[25]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[25]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[25]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[25]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[25]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[25]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[25]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[25]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[25]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[25]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[25]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[25]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[25]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[25]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[25]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[25]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[25]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[25]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[25]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[26]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[26]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[26]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[26]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[26]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[26]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[26]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[26]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[26]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[26]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[26]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[26]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[26]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[26]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[26]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[26]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[26]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[26]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[26]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[26]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[26]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[26]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[26]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[26]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[26]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[26]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[26]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[26]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[26]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[26]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[26]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[26]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[26]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[26]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[26]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[26]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[26]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[26]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[26]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[26]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[26]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[26]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[26]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[26]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[26]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[26]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[26]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[26]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[26]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[26]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[26]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[26]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[26]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[26]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[27]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[27]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[27]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[27]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[27]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[27]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[27]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[27]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[27]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[27]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[27]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[27]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[27]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[27]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[27]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[27]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[27]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[27]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[27]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[27]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[27]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[27]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[27]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[27]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[27]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[27]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[27]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[27]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[27]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[27]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[27]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[27]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[27]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[27]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[27]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[27]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[27]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[27]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[27]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[27]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[27]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[27]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[27]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[27]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[27]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[27]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[27]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[27]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[27]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[27]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[27]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[27]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[27]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[27]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[28]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[28]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[28]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[28]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[28]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[28]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[28]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[28]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[28]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[28]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[28]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[28]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[28]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[28]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[28]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[28]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[28]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[28]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[28]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[28]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[28]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[28]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[28]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[28]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[28]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[28]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[28]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[28]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[28]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[28]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[28]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[28]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[28]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[28]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[28]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[28]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[28]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[28]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[28]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[28]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[28]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[28]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[28]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[28]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[28]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[28]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[28]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[28]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[28]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[28]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[28]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[28]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[28]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[28]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[29]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[29]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[29]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[29]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[29]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[29]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[29]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[29]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[29]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[29]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[29]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[29]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[29]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[29]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[29]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[29]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[29]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[29]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[29]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[29]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[29]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[29]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[29]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[29]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[29]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[29]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[29]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[29]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[29]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[29]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[29]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[29]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[29]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[29]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[29]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[29]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[29]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[29]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[29]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[29]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[29]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[29]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[29]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[29]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[29]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[29]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[29]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[29]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[29]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[29]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[29]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[29]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[29]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[29]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[30]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[30]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[30]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[30]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[30]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[30]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[30]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[30]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[30]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[30]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[30]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[30]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[30]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[30]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[30]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[30]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[30]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[30]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[30]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[30]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[30]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[30]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[30]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[30]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[30]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[30]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[30]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[30]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[30]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[30]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[30]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[30]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[30]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[30]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[30]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[30]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[30]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[30]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[30]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[30]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[30]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[30]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[30]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[30]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[30]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[30]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[30]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[30]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[30]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[30]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[30]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[30]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[30]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[30]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[31]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[31]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[31]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[31]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[31]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[31]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[31]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[31]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[31]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[31]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[31]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[31]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[31]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[31]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[31]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[31]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[31]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[31]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[31]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[31]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[31]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[31]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[31]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[31]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[31]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[31]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[31]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[31]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[31]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[31]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[31]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[31]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[31]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[31]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[31]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[31]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[31]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[31]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[31]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[31]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[31]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[31]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[31]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[31]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[31]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[31]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[31]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[31]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[31]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[31]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[31]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[31]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[32]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[32]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[32]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[32]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[32]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[32]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[32]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[32]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[32]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[32]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[32]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[32]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[32]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[32]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[32]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[32]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[32]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[32]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[32]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[32]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[32]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[32]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[32]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[32]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[32]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[32]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[32]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[32]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[32]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[32]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[32]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[32]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[32]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[32]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[32]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[32]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[32]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[32]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[32]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[32]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[32]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[32]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[32]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[32]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[32]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[32]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[32]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[32]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[32]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[32]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[32]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[32]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[33]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[33]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[33]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[33]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[33]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[33]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[33]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[33]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[33]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[33]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[33]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[33]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[33]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[33]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[33]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[33]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[33]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[33]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[33]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[33]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[33]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[33]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[33]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[33]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[33]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[33]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[33]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[33]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[33]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[33]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[33]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[33]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[33]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[33]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[33]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[33]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[33]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[33]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[33]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[33]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[33]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[33]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[33]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[33]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[33]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[33]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[33]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[33]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[33]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[33]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[33]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[33]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[33]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[33]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[34]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[34]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[34]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[34]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[34]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[34]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[34]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[34]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[34]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[34]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[34]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[34]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[34]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[34]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[34]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[34]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[34]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[34]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[34]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[34]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[34]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[34]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[34]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[34]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[34]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[34]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[34]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[34]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[34]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[34]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[34]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[34]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[34]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[34]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[34]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[34]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[34]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[34]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[34]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[34]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[34]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[34]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[34]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[34]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[34]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[34]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[34]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[34]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[34]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[34]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[34]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[34]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[35]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[35]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[35]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[35]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[35]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[35]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[35]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[35]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[35]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[35]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[35]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[35]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[35]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[35]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[35]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[35]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[35]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[35]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[35]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[35]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[35]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[35]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[35]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[35]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[35]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[35]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[35]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[35]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[35]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[35]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[35]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[35]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[35]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[35]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[35]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[35]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[35]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[35]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[35]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[35]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[35]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[35]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[35]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[35]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[35]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[35]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[35]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[35]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[35]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[35]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[35]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[35]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[35]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[35]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[36]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[36]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[36]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[36]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[36]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[36]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[36]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[36]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[36]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[36]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[36]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[36]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[36]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[36]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[36]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[36]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[36]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[36]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[36]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[36]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[36]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[36]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[36]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[36]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[36]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[36]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[36]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[36]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[36]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[36]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[36]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[36]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[36]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[36]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[36]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[36]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[36]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[36]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[36]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[36]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[36]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[36]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[36]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[36]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[36]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[36]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[36]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[36]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[36]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[36]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[36]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[36]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[36]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[36]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[37]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[37]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[37]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[37]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[37]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[37]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[37]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[37]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[37]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[37]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[37]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[37]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[37]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[37]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[37]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[37]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[37]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[37]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[37]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[37]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[37]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[37]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[37]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[37]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[37]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[37]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[37]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[37]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[37]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[37]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[37]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[37]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[37]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[37]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[37]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[37]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[37]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[37]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[37]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[37]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[37]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[37]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[37]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[37]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[37]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[37]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[37]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[37]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[37]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[37]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[37]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[37]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[37]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[37]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/chain/kinetics[38]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[38]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[38]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[38]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[38]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[38]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[38]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[38]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[38]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[38]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[38]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[38]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[38]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[38]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[38]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[38]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[38]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[38]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[38]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[38]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[38]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[38]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[38]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[38]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[38]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[38]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[38]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[38]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[38]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[38]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[38]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[38]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[38]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[38]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[38]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[38]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[38]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[38]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[38]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[38]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[38]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[38]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" call /kinetics/chain/kinetics[38]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[38]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras, but as of" \ "March 17, 2006, the kcat is scaled from 0.02 to 0.2 to" \ "have a stronger Ca response for the direct MAPK input." \ "" call /kinetics/chain/kinetics[38]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[38]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[38]/CaM/CaM-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[38]/CaM/CaM-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[38]/CaM/CaM-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[38]/CaM/CaM-Ca-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)" \ "" \ "19 May 2006. Splitting the old CaM-TR2-bind-Ca reaction into" \ "two steps, each binding 1 Ca. This improves numerical" \ "stability and is conceptually better too." \ "" \ "Overall rates are the same, so each kf and kb is the " \ "square root of the earlier ones. So" \ "kf = 1.125e-4, kb = 8.4853" \ "" call /kinetics/chain/kinetics[38]/CaM/CaM-Ca/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[38]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[38]/PKM/AA_pool/notes LOAD \ "Amino acid pool for synthesis." call /kinetics/chain/kinetics[38]/PKM/PKM_degradation/notes LOAD \ "Time-course of 2 hours." call /kinetics/doqcsinfo/notes LOAD \ "This is a 40-compartment reaction-diffusion-transport version of the Ajay_Bhalla_2007_PKM model. The original single-compartment model is repeated 40 times. In addition, a subset (27 out of 42) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. For D = 1e-12 m^2/sec (i.e., 1 micron^2/sec ) the kf and kb of this reaction for these 10 micron compartments are both 0.01/sec" \ "In addition, we have a forward (dendrite to soma) transport term of 1 microns/sec. This converts to a rate of 0.1/sec, but applies only to the kf. So the total kf of the diffusion 'reaction' is 0.11 for D = 1 micron^2/sec, and kb is 0.01. If D=0.1 micron^2/sec then kf = 0.101 and kb = 0.001." \ "In addition this model has all molecules buffered in the first and last compartments. This boundary conditions says that the molecules are not drained out of the first compartment, nor do they all pile up in the last one.
The stimulus file pkm_mapk22_transp_endbuf_D1e-13_Fig4CD which was used for the model to replicate Figure 4C and 4D from the paper." complete_loading