//genesis // kkit Version 11 flat dumpfile // Saved on Fri Dec 8 16:03:25 2006 include kkit {argv 1} FASTDT = 2e-05 SIMDT = 0.001 CONTROLDT = 10 PLOTDT = 1 MAXTIME = 2500 TRANSIENT_TIME = 2 VARIABLE_DT_FLAG = 1 DEFAULT_VOL = 1.2566e-16 VERSION = 11.0 setfield /file/modpath value /home2/bhalla/scripts/modules kparms //genesis initdump -version 3 -ignoreorphans 1 simobjdump doqcsinfo filename accessname accesstype transcriber developer \ citation species tissue cellcompartment methodology sources \ model_implementation model_validation x y z simobjdump table input output alloced step_mode stepsize x y z simobjdump xtree path script namemode sizescale simobjdump xcoredraw xmin xmax ymin ymax simobjdump xtext editable simobjdump xgraph xmin xmax ymin ymax overlay simobjdump xplot pixflags script fg ysquish do_slope wy simobjdump group xtree_fg_req xtree_textfg_req plotfield expanded movealone \ link savename file version md5sum mod_save_flag x y z simobjdump geometry size dim shape outside xtree_fg_req xtree_textfg_req x y \ z simobjdump kpool DiffConst CoInit Co n nInit mwt nMin vol slave_enable \ geomname xtree_fg_req xtree_textfg_req x y z simobjdump kreac kf kb notes xtree_fg_req xtree_textfg_req x y z simobjdump kenz CoComplexInit CoComplex nComplexInit nComplex vol k1 k2 k3 \ keepconc usecomplex notes xtree_fg_req xtree_textfg_req link x y z simobjdump stim level1 width1 delay1 level2 width2 delay2 baselevel trig_time \ trig_mode notes xtree_fg_req xtree_textfg_req is_running x y z simobjdump xtab input output alloced step_mode stepsize notes editfunc \ xtree_fg_req xtree_textfg_req baselevel last_x last_y is_running x y z simobjdump kchan perm gmax Vm is_active use_nernst notes xtree_fg_req \ xtree_textfg_req x y z simobjdump transport input output alloced step_mode stepsize dt delay clock \ kf xtree_fg_req xtree_textfg_req x y z simobjdump proto x y z simundump geometry /kinetics/dendgeom 0 1.257e-16 3 cylinder "" white black \ 19 -17 0 simundump group /kinetics/PKC 0 blue black x 0 0 "" defaultfile defaultfile.g \ 0 0 0 8.9507 -3.7837 0 simundump kpool /kinetics/PKC/PKC-Ca 0 -1e-12 3.7208e-17 3.7208e-17 \ 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black 7.9248 \ -10.489 0 simundump kreac /kinetics/PKC/PKC-Ca/diff 0 0.001 0.001 "" white black 8.9248 \ -7.489 0 simundump kreac /kinetics/PKC/PKC-act-by-Ca 0 7.958e-06 0.5 "" white blue \ 7.9248 -12.123 0 simundump kreac /kinetics/PKC/PKC-act-by-DAG 0 1.061e-07 8.6348 "" white blue \ 9.9388 -11.306 0 simundump kreac /kinetics/PKC/PKC-Ca-to-memb 0 1.2705 3.5026 "" white blue \ 8.2026 -7.7467 0 simundump kreac /kinetics/PKC/PKC-DAG-to-memb 0 1 0.1 "" white blue 9.3832 \ -9.2638 0 simundump kreac /kinetics/PKC/PKC-act-by-Ca-AA 0 1.5916e-08 0.1 "" white blue \ 11.212 -8.1843 0 simundump kreac /kinetics/PKC/PKC-act-by-DAG-AA 0 2 0.2 "" white blue 13.249 \ -8.7678 0 simundump kpool /kinetics/PKC/PKC-DAG-AA* 0 -1e-12 4.9137e-18 4.9137e-18 \ 3.7047e-13 3.7047e-13 0 0 75396 0 /kinetics/dendgeom cyan blue 12.601 \ -6.463 0 simundump kreac /kinetics/PKC/PKC-DAG-AA*/diff 0 0.001 0.001 "" white black \ 13.601 -3.463 0 simundump kpool /kinetics/PKC/PKC-Ca-AA* 0 -1e-12 1.7501e-16 1.7501e-16 \ 1.3195e-11 1.3195e-11 0 0 75396 0 /kinetics/dendgeom orange blue 11.397 \ -5.7044 0 simundump kreac /kinetics/PKC/PKC-Ca-AA*/diff 0 0.001 0.001 "" white black \ 12.397 -2.7044 0 simundump kpool /kinetics/PKC/PKC-Ca-memb* 0 -1e-12 1.3896e-17 1.3896e-17 \ 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom pink blue 9.2212 \ -5.471 0 simundump kreac /kinetics/PKC/PKC-Ca-memb*/diff 0 0.001 0.001 "" white black \ 10.221 -2.471 0 simundump kpool /kinetics/PKC/PKC-DAG-memb* 0 -1e-12 9.4351e-21 9.4351e-21 \ 7.1137e-16 7.1137e-16 0 0 75396 0 /kinetics/dendgeom yellow blue 10.17 \ -6.4922 0 simundump kreac /kinetics/PKC/PKC-DAG-memb*/diff 0 0.001 0.001 "" white black \ 11.17 -3.4922 0 simundump kpool /kinetics/PKC/PKC-basal* 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom pink blue 7.2535 -6.4338 0 simundump kreac /kinetics/PKC/PKC-basal*/diff 0 0.001 0.001 "" white black \ 8.2535 -3.4338 0 simundump kreac /kinetics/PKC/PKC-basal-act 0 1 50 "" white blue 7.022 \ -8.9429 0 simundump kpool /kinetics/PKC/PKC-AA* 0 -1e-12 1.8134e-17 1.8134e-17 \ 1.3672e-12 1.3672e-12 0 0 75396 0 /kinetics/dendgeom cyan blue 13.782 \ -5.1793 0 simundump kreac /kinetics/PKC/PKC-AA*/diff 0 0.001 0.001 "" white black \ 14.782 -2.1793 0 simundump kreac /kinetics/PKC/PKC-act-by-AA 0 1.5916e-09 0.1 "" white blue \ 7.0075 -13.865 0 simundump kpool /kinetics/PKC/PKC-Ca-DAG 0 -1e-12 8.4632e-23 8.4632e-23 \ 6.3809e-18 6.3809e-18 0 0 75396 0 /kinetics/dendgeom white blue 12.231 \ -10.197 0 simundump kreac /kinetics/PKC/PKC-Ca-DAG/diff 0 0.001 0.001 "" white black \ 13.231 -7.197 0 simundump kreac /kinetics/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" white blue 8.9897 \ -13.99 0 simundump kpool /kinetics/PKC/PKC-DAG 0 -1e-12 1.161e-16 1.161e-16 8.7535e-12 \ 8.7535e-12 0 0 75396 0 /kinetics/dendgeom white blue 11.004 -13.086 0 simundump kreac /kinetics/PKC/PKC-DAG/diff 0 0.001 0.001 "" white black \ 12.004 -10.086 0 simundump kreac /kinetics/PKC/PKC-n-DAG-AA 0 2.3874e-07 2 "" white blue \ 10.772 -14.953 0 simundump kpool /kinetics/PKC/PKC-DAG-AA 0 -1e-12 2.5188e-19 2.5188e-19 \ 1.8991e-14 1.8991e-14 0 0 75396 0 /kinetics/dendgeom white blue 12.624 \ -11.773 0 simundump kreac /kinetics/PKC/PKC-DAG-AA/diff 0 0.001 0.001 "" white black \ 13.624 -8.773 0 simundump kpool /kinetics/PKC/PKC-cytosolic 0 -1e-12 1 1 75396 75396 0 0 \ 75396 0 /kinetics/dendgeom white blue 5.8685 -11.403 0 simundump kreac /kinetics/PKC/PKC-cytosolic/diff 0 0.001 0.001 "" white black \ 6.8685 -8.403 0 simundump kpool /kinetics/AA 0 -1e-12 0 0 0 0 0 0 75396 0 /kinetics/dendgeom \ darkgreen black 8.7102 -21.338 0 simundump kreac /kinetics/AA/diff 0 0.001 0.001 "" white black 9.7102 -18.338 \ 0 simundump group /kinetics/PLA2 0 darkgreen black x 0 1 "" defaultfile \ defaultfile.g 0 0 0 4.6428 -26.209 0 simundump kpool /kinetics/PLA2/PLA2-cytosolic 0 -1e-12 0.39999 0.39999 30158 \ 30158 0 0 75396 0 /kinetics/dendgeom yellow darkgreen 0.176 -20.942 0 simundump kreac /kinetics/PLA2/PLA2-cytosolic/diff 0 0.001 0.001 "" white \ black 1.176 -17.942 0 simundump kreac /kinetics/PLA2/PLA2-Ca-act 0 1.3263e-05 0.1 "" white \ darkgreen 0.903 -23.104 0 simundump kpool /kinetics/PLA2/PLA2-Ca* 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom yellow darkgreen 3.278 -23.646 0 simundump kenz /kinetics/PLA2/PLA2-Ca*/kenz 0 0 0 0 0 75396 1.7906e-05 21.6 \ 5.4 0 0 "" red yellow "" 5.9447 -23.667 0 simundump kreac /kinetics/PLA2/PLA2-Ca*/diff 0 0.001 0.001 "" white black \ 4.278 -20.646 0 simundump kreac /kinetics/PLA2/PIP2-PLA2-act 0 1.5916e-08 0.5 "" white \ darkgreen 0.945 -18.75 0 simundump kpool /kinetics/PLA2/PIP2-PLA2* 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom cyan darkgreen 3.3197 -18.292 0 simundump kenz /kinetics/PLA2/PIP2-PLA2*/kenz 0 0 0 0 0 75396 3.6607e-05 \ 44.16 11.04 0 0 "" red cyan "" 5.9655 -18.271 0 simundump kreac /kinetics/PLA2/PIP2-PLA2*/diff 0 0.001 0.001 "" white black \ 4.3197 -15.292 0 simundump kreac /kinetics/PLA2/PIP2-Ca-PLA2-act 0 1.5916e-07 0.1 "" white \ darkgreen 1.903 -19.5 0 simundump kpool /kinetics/PLA2/PIP2-Ca-PLA2* 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom cyan darkgreen 3.6739 -19.896 0 simundump kenz /kinetics/PLA2/PIP2-Ca-PLA2*/kenz 0 0 0 0 0 75396 0.00011937 \ 144 36 0 0 "" red cyan "" 6.028 -19.979 0 simundump kreac /kinetics/PLA2/PIP2-Ca-PLA2*/diff 0 0.001 0.001 "" white \ black 4.6739 -16.896 0 simundump kreac /kinetics/PLA2/DAG-Ca-PLA2-act 0 3.979e-08 4 "" white \ darkgreen 1.174 -21.834 0 simundump kpool /kinetics/PLA2/DAG-Ca-PLA2* 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom pink darkgreen 3.8614 -22.479 0 simundump kenz /kinetics/PLA2/DAG-Ca-PLA2*/kenz 0 0 0 0 0 75396 0.00019895 \ 240 60 0 0 "" red pink "" 6.0489 -22.354 0 simundump kreac /kinetics/PLA2/DAG-Ca-PLA2*/diff 0 0.001 0.001 "" white black \ 4.8614 -19.479 0 simundump kpool /kinetics/PLA2/APC 0 -1e-12 30 30 2.2619e+06 2.2619e+06 0 0 \ 75396 4 /kinetics/dendgeom yellow darkgreen 3.7614 -21.963 0 simundump kreac /kinetics/PLA2/Degrade-AA 1 0.4 0 "" white darkgreen 5.8192 \ -17.288 0 simundump kpool /kinetics/PLA2/PLA2*-Ca 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom orange darkgreen 4.187 -24.687 0 simundump kenz /kinetics/PLA2/PLA2*-Ca/kenz 0 0 0 0 0 75396 0.0003979 480 120 \ 0 0 "" red orange "" 5.9186 -24.817 0 simundump kreac /kinetics/PLA2/PLA2*-Ca/diff 0 0.001 0.001 "" white black \ 5.187 -21.687 0 simundump kpool /kinetics/PLA2/PLA2* 1 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom orange darkgreen 2.975 -26.851 0 simundump kreac /kinetics/PLA2/PLA2*/diff 0 0.001 0.001 "" white black 3.975 \ -23.851 0 simundump kreac /kinetics/PLA2/PLA2*-Ca-act 1 7.958e-05 0.1 "" white \ darkgreen 1.914 -24.752 0 simundump kreac /kinetics/PLA2/dephosphorylate-PLA2* 1 0.17 0 "" white \ darkgreen -1.693 -23.735 0 simundump kpool /kinetics/temp-PIP2 1 -1e-12 2.5 2.5 1.8849e+05 1.8849e+05 0 \ 0 75396 4 /kinetics/dendgeom green black -3.796 -19.047 0 simundump group /kinetics/MAPK 0 brown black x 0 0 "" defaultfile \ defaultfile.g 0 0 0 27 -1 0 simundump kpool /kinetics/MAPK/craf-1 0 0 0.5 0.5 37698 37698 0 0 75396 0 \ /kinetics/dendgeom pink brown 18 -4 0 simundump kpool /kinetics/MAPK/craf-1* 0 0 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom pink brown 21 -4 0 simundump kpool /kinetics/MAPK/MAPKK 0 0 0.5 0.5 37698 37698 0 0 75396 0 \ /kinetics/dendgeom pink brown 18 -8 0 simundump kpool /kinetics/MAPK/MAPK 0 -1e-12 3.5999 3.5999 2.7142e+05 \ 2.7142e+05 0 0 75396 0 /kinetics/dendgeom pink brown 18 -11 0 simundump kreac /kinetics/MAPK/MAPK/diff 0 0.001 0.001 "" white black 19 -8 0 simundump kpool /kinetics/MAPK/craf-1** 1 0 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom hotpink brown 24 -4 0 simundump kpool /kinetics/MAPK/MAPK-tyr 1 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom orange brown 21 -11 0 simundump kreac /kinetics/MAPK/MAPK-tyr/diff 0 0.001 0.001 "" white black 22 \ -8 0 simundump kpool /kinetics/MAPK/MAPKK* 0 0 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom pink brown 25 -8 0 simundump kenz /kinetics/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 75396 0.00042973 1.2 \ 0.3 0 0 "" red pink "" 20 -9 0 simundump kenz /kinetics/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 75396 0.00042973 1.2 \ 0.3 0 0 "" red pink "" 25 -9 0 simundump kpool /kinetics/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom pink brown 21 -8 0 simundump kpool /kinetics/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom 55 brown 17 -6 0 simundump kenz /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 0 0 0 0 75396 \ 0.00012505 1.2 0.3 0 0 "" red 55 "" 20 -6 0 simundump kenz /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 0 0 0 0 75396 \ 0.00012505 1.2 0.3 0 0 "" red 55 "" 23 -6 0 simundump kpool /kinetics/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom red brown 17 -7 0 simundump kenz /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 0 0 0 0 0.12566 \ 0.00012505 1.2 0.3 0 0 "" red red "" 20 -7 0 simundump kenz /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 0 0 0 0 0.12566 \ 0.00012505 1.2 0.3 0 0 "" red red "" 23 -7 0 simundump kreac /kinetics/Ras-act-craf 1 0.00013263 0.5 "" white black 15 -3 \ 0 simundump group /kinetics/Ras 1 blue black x 0 0 "" defaultfile defaultfile.g \ 0 0 0 26.513 4.351 0 simundump kreac /kinetics/Ras/dephosph-GEF 1 1 0 "" white blue 21.07 5.881 0 simundump kpool /kinetics/Ras/inact-GEF 1 -1e-12 0.1 0.1 7539.6 7539.6 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 24.453 6.352 0 simundump kenz /kinetics/Ras/inact-GEF/basal_GEF_activity 0 0 0 0 0 75396 \ 1.313e-07 0.08 0.02 0 0 "" red hotpink "" 23 5 0 simundump kreac /kinetics/Ras/inact-GEF/diff 0 0.001 0.001 "" white black \ 25.453 9.352 0 simundump kpool /kinetics/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom hotpink blue 18.448 5.246 0 simundump kenz /kinetics/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 75396 2.6261e-06 \ 0.08 0.02 0 0 "" red hotpink "" 19.085 4.086 0 simundump kreac /kinetics/Ras/GEF*/diff 0 0.001 0.001 "" white black 19.448 \ 8.246 0 simundump kpool /kinetics/Ras/GTP-Ras 1 0 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom orange blue 24.564 1.084 0 simundump kpool /kinetics/Ras/GDP-Ras 1 0 0.5 0.5 37698 37698 0 0 75396 0 \ /kinetics/dendgeom pink blue 18.131 2.165 0 simundump kreac /kinetics/Ras/Ras-intrinsic-GTPase 1 1e-04 0 "" white blue \ 21.098 1.5 0 simundump kreac /kinetics/Ras/dephosph-GAP 1 0.1 0 "" white blue 16.023 3.524 \ 0 simundump kpool /kinetics/Ras/GAP* 1 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom red blue 13.35 2.349 0 simundump kreac /kinetics/Ras/GAP*/diff 0 0.001 0.001 "" white black 14.35 \ 5.349 0 simundump kpool /kinetics/Ras/GAP 1 -1e-12 0.01 0.01 753.96 753.96 0 0 75396 \ 0 /kinetics/dendgeom red blue 18.655 0.338 0 simundump kenz /kinetics/Ras/GAP/GAP-inact-ras 1 0 0 0 0 75396 0.00065634 40 \ 10 0 0 "" red red "" 21.012 0.403 0 simundump kreac /kinetics/Ras/GAP/diff 0 0.001 0.001 "" white black 19.655 \ 3.338 0 simundump kreac /kinetics/Ras/CaM-bind-GEF 1 0.0026526 1 "" white blue 14.486 \ 9.679 0 simundump kpool /kinetics/Ras/CaM-GEF 1 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom pink blue 17.345 7.58 0 simundump kenz /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 0 0 75396 \ 1.3131e-05 0.4 0.1 0 0 "" red pink "" 17.022 6.657 0 simundump kreac /kinetics/Ras/CaM-GEF/diff 0 0.001 0.001 "" white black \ 18.345 10.58 0 simundump kpool /kinetics/Ca 1 -1e-12 0.095 0.095 7162.6 7162.6 0 0 75396 4 \ /kinetics/dendgeom red black -3 -13 0 simundump kpool /kinetics/DAG 1 -1e-12 12.2 12.2 9.1983e+05 9.1983e+05 0 0 \ 75396 4 /kinetics/dendgeom green black 12.718 -19.562 0 simundump kpool /kinetics/PKC-active 1 -1e-12 0.3 2.1196e-16 1.5981e-11 22619 \ 0 0 75396 2 /kinetics/dendgeom red black 12 -3 0 simundump kenz /kinetics/PKC-active/PKC-act-raf 1 0 0 0 0 75396 3.979e-06 16 \ 4 0 0 "" red yellow "" 18 -2 0 simundump kenz /kinetics/PKC-active/PKC-inact-GAP 1 0 0 0 0 0.12566 7.958e-05 \ 16 4 0 0 "" red yellow "" 16 1 0 simundump kenz /kinetics/PKC-active/PKC-act-GEF 1 0 0 0 0 0.12566 7.958e-05 \ 16 4 0 0 "" red yellow "" 21 8 0 simundump kenz /kinetics/PKC-active/phosph-AC2 1 0 0 0 0 75396 0.00066667 16 \ 4 0 0 "" red red "" 5.3178 -23.269 0 simundump kpool /kinetics/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom orange yellow 25 -11 0 simundump kenz /kinetics/MAPK*/MAPK* 0 0 0 0 0 75396 2.5864e-05 40 10 0 0 "" \ red orange "" 0 -26 0 simundump kenz /kinetics/MAPK*/MAPK*-feedback 1 0 0 0 0 75396 2.5864e-05 40 \ 10 0 0 "" red orange "" 22 -2 0 simundump kreac /kinetics/MAPK*/diff 0 0.001 0.001 "" white black 26 -8 0 simundump kpool /kinetics/IP3 1 -1e-12 0.73 0.73 55039 55039 0 0 75396 4 \ /kinetics/dendgeom pink black 11.226 -16.656 0 simundump kpool /kinetics/MKP-1 1 -1e-12 0.024 0.024 1809.5 1809.5 0 0 75396 \ 0 /kinetics/dendgeom hotpink black 17 -10 0 simundump kenz /kinetics/MKP-1/MKP1-tyr-deph 1 0 0 0 0 75396 0.0019895 16 4 0 \ 0 "" red hotpink "" 18 -9 0 simundump kenz /kinetics/MKP-1/MKP1-thr-deph 1 0 0 0 0 75396 0.0019895 16 4 0 \ 0 "" red hotpink "" 23 -9 0 simundump kreac /kinetics/MKP-1/diff 0 0.001 0.001 "" white black 18 -7 0 simundump kpool /kinetics/PPhosphatase2A 1 -1e-12 1 1 75396 75396 0 0 75396 0 \ /kinetics/dendgeom hotpink yellow 21 -3 0 simundump kenz /kinetics/PPhosphatase2A/craf-deph 1 0 0 0 0 75396 2.5414e-05 \ 24 6 0 0 "" red hotpink "" 20 -2 0 simundump kenz /kinetics/PPhosphatase2A/MAPKK-deph 1 0 0 0 0 75396 2.5414e-05 \ 24 6 0 0 "" red hotpink "" 23 -5 0 simundump kenz /kinetics/PPhosphatase2A/MAPKK-deph-ser 1 0 0 0 0 75396 \ 2.5414e-05 24 6 0 0 "" red hotpink "" 20 -5 0 simundump kenz /kinetics/PPhosphatase2A/craf**-deph 1 0 0 0 0 0.12566 \ 2.5414e-05 24 6 0 0 "" red hotpink "" 24 -2 0 simundump kreac /kinetics/PPhosphatase2A/diff 0 0.001 0.001 "" white black 22 \ 0 0 simundump group /kinetics/CaM 1 blue black x 0 0 "" defaultfile defaultfile.g \ 0 0 0 -1 -9 0 simundump kpool /kinetics/CaM/CaM 1 -1e-12 20 20 1.5079e+06 1.5079e+06 0 0 \ 75396 0 /kinetics/dendgeom pink blue -1.017 -1.28 0 simundump kreac /kinetics/CaM/CaM/diff 0 0.001 0.001 "" white black -0.017 \ 1.72 0 simundump kreac /kinetics/CaM/CaM-TR2-bind-Ca 1 1.2666e-08 72 "" white blue \ 1.162 -1.921 0 simundump kreac /kinetics/CaM/CaM-TR2-Ca2-bind-Ca 1 4.7748e-05 10 "" white \ blue 0.158 -3.7747 0 simundump kreac /kinetics/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 10 "" white blue \ -1.4 -6.7404 0 simundump kpool /kinetics/CaM/CaM-Ca3 1 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom hotpink blue 2.489 -5.603 0 simundump kreac /kinetics/CaM/CaM-Ca3/diff 0 0.001 0.001 "" white black 3.489 \ -2.603 0 simundump kpool /kinetics/CaM/CaM-TR2-Ca2 1 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom pink blue 3.999 -2.7423 0 simundump kreac /kinetics/CaM/CaM-TR2-Ca2/diff 0 0.001 0.001 "" white black \ 4.999 0.2577 0 simundump kpool /kinetics/CaM/CaM-Ca4 1 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom blue blue 4 -8 0 simundump kreac /kinetics/CaM/CaM-Ca4/diff 0 0.001 0.001 "" white black 5 -5 \ 0 simundump kreac /kinetics/Ras-act-unphosph-raf 0 7.958e-05 1 "" white black \ 16 -4 0 simundump kpool /kinetics/Ca_input 0 -1e-12 0.08 0.08 6031.7 6031.7 0 0 75396 \ 4 /kinetics/dendgeom 61 black -10 -7 0 simundump kreac /kinetics/Ca_diff 0 2 2 "" white black -9 -12 0 simundump group /kinetics/chain 0 yellow black x 0 0 "" defaultfile \ defaultfile.g 0 0 0 4 0 0 simundump group /kinetics/chain/kinetics 0 yellow black x 0 0 "" defaultfile \ defaultfile.g 0 0 0 4 0 0 simundump group /kinetics/chain/kinetics/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 12.951 -3.7837 0 simundump kpool /kinetics/chain/kinetics/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 11.925 -10.489 0 simundump kreac /kinetics/chain/kinetics/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 12.925 -7.489 0 simundump kreac /kinetics/chain/kinetics/PKC/PKC-act-by-Ca 0 7.958e-06 0.5 "" \ white blue 11.925 -12.123 0 simundump kreac /kinetics/chain/kinetics/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 13.939 -11.306 0 simundump kreac /kinetics/chain/kinetics/PKC/PKC-Ca-to-memb 0 1.2705 3.5026 \ "" white blue 12.203 -7.7467 0 simundump kreac /kinetics/chain/kinetics/PKC/PKC-DAG-to-memb 0 1 0.1 "" white \ blue 13.383 -9.2638 0 simundump kreac /kinetics/chain/kinetics/PKC/PKC-act-by-Ca-AA 0 1.5916e-08 \ 0.1 "" white blue 15.212 -8.1843 0 simundump kreac /kinetics/chain/kinetics/PKC/PKC-act-by-DAG-AA 0 2 0.2 "" \ white blue 17.249 -8.7678 0 simundump kpool /kinetics/chain/kinetics/PKC/PKC-DAG-AA* 0 -1e-12 4.9137e-18 \ 4.9137e-18 3.7047e-13 3.7047e-13 0 0 75396 0 /kinetics/dendgeom cyan blue \ 16.601 -6.463 0 simundump kreac /kinetics/chain/kinetics/PKC/PKC-DAG-AA*/diff 0 0.001 0.001 \ "" white black 17.601 -3.463 0 simundump kpool /kinetics/chain/kinetics/PKC/PKC-Ca-AA* 0 -1e-12 1.7501e-16 \ 1.7501e-16 1.3195e-11 1.3195e-11 0 0 75396 0 /kinetics/dendgeom orange blue \ 15.397 -5.7044 0 simundump kreac /kinetics/chain/kinetics/PKC/PKC-Ca-AA*/diff 0 0.001 0.001 "" \ white black 16.397 -2.7044 0 simundump kpool /kinetics/chain/kinetics/PKC/PKC-Ca-memb* 0 -1e-12 1.3896e-17 \ 1.3896e-17 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom pink blue \ 13.221 -5.471 0 simundump kreac /kinetics/chain/kinetics/PKC/PKC-Ca-memb*/diff 0 0.001 0.001 \ "" white black 14.221 -2.471 0 simundump kpool /kinetics/chain/kinetics/PKC/PKC-DAG-memb* 0 -1e-12 \ 9.4351e-21 9.4351e-21 7.1137e-16 7.1137e-16 0 0 75396 0 /kinetics/dendgeom \ yellow blue 14.17 -6.4922 0 simundump kreac /kinetics/chain/kinetics/PKC/PKC-DAG-memb*/diff 0 0.001 0.001 \ "" white black 15.17 -3.4922 0 simundump kpool /kinetics/chain/kinetics/PKC/PKC-basal* 0 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 11.253 -6.4338 0 simundump kreac /kinetics/chain/kinetics/PKC/PKC-basal*/diff 0 0.001 0.001 "" \ white black 12.253 -3.4338 0 simundump kreac /kinetics/chain/kinetics/PKC/PKC-basal-act 0 1 50 "" white \ blue 11.022 -8.9429 0 simundump kpool /kinetics/chain/kinetics/PKC/PKC-AA* 0 -1e-12 1.8134e-17 \ 1.8134e-17 1.3672e-12 1.3672e-12 0 0 75396 0 /kinetics/dendgeom cyan blue \ 17.782 -5.1793 0 simundump kreac /kinetics/chain/kinetics/PKC/PKC-AA*/diff 0 0.001 0.001 "" \ white black 18.782 -2.1793 0 simundump kreac /kinetics/chain/kinetics/PKC/PKC-act-by-AA 0 1.5916e-09 0.1 \ "" white blue 11.007 -13.865 0 simundump kpool /kinetics/chain/kinetics/PKC/PKC-Ca-DAG 0 -1e-12 8.4632e-23 \ 8.4632e-23 6.3809e-18 6.3809e-18 0 0 75396 0 /kinetics/dendgeom white blue \ 16.231 -10.197 0 simundump kreac /kinetics/chain/kinetics/PKC/PKC-Ca-DAG/diff 0 0.001 0.001 "" \ white black 17.231 -7.197 0 simundump kreac /kinetics/chain/kinetics/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 12.99 -13.99 0 simundump kpool /kinetics/chain/kinetics/PKC/PKC-DAG 0 -1e-12 1.161e-16 \ 1.161e-16 8.7535e-12 8.7535e-12 0 0 75396 0 /kinetics/dendgeom white blue \ 15.004 -13.086 0 simundump kreac /kinetics/chain/kinetics/PKC/PKC-DAG/diff 0 0.001 0.001 "" \ white black 16.004 -10.086 0 simundump kreac /kinetics/chain/kinetics/PKC/PKC-n-DAG-AA 0 2.3874e-07 2 "" \ white blue 14.772 -14.953 0 simundump kpool /kinetics/chain/kinetics/PKC/PKC-DAG-AA 0 -1e-12 2.5188e-19 \ 2.5188e-19 1.8991e-14 1.8991e-14 0 0 75396 0 /kinetics/dendgeom white blue \ 16.624 -11.773 0 simundump kreac /kinetics/chain/kinetics/PKC/PKC-DAG-AA/diff 0 0.001 0.001 "" \ white black 17.624 -8.773 0 simundump kpool /kinetics/chain/kinetics/PKC/PKC-cytosolic 0 -1e-12 1 1 75396 \ 75396 0 0 75396 0 /kinetics/dendgeom white blue 9.8685 -11.403 0 simundump kreac /kinetics/chain/kinetics/PKC/PKC-cytosolic/diff 0 0.001 0.001 \ "" white black 10.868 -8.403 0 simundump kpool /kinetics/chain/kinetics/AA 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom darkgreen black 12.71 -21.338 0 simundump kreac /kinetics/chain/kinetics/AA/diff 0 0.001 0.001 "" white black \ 13.71 -18.338 0 simundump group /kinetics/chain/kinetics/PLA2 0 darkgreen black x 0 1 "" \ defaultfile defaultfile.g 0 0 0 8.6428 -26.209 0 simundump kpool /kinetics/chain/kinetics/PLA2/PLA2-cytosolic 0 -1e-12 0.39999 \ 0.39999 30158 30158 0 0 75396 0 /kinetics/dendgeom yellow darkgreen 4.176 \ -20.942 0 simundump kreac /kinetics/chain/kinetics/PLA2/PLA2-cytosolic/diff 0 0.001 \ 0.001 "" white black 5.176 -17.942 0 simundump kreac /kinetics/chain/kinetics/PLA2/PLA2-Ca-act 0 1.3263e-05 0.1 "" \ white darkgreen 4.903 -23.104 0 simundump kpool /kinetics/chain/kinetics/PLA2/PLA2-Ca* 0 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom yellow darkgreen 7.278 -23.646 0 simundump kenz /kinetics/chain/kinetics/PLA2/PLA2-Ca*/kenz 0 0 0 0 0 75396 \ 1.7906e-05 21.6 5.4 0 0 "" red yellow "" 9.9447 -23.667 0 simundump kreac /kinetics/chain/kinetics/PLA2/PLA2-Ca*/diff 0 0.001 0.001 "" \ white black 8.278 -20.646 0 simundump kreac /kinetics/chain/kinetics/PLA2/PIP2-PLA2-act 0 1.5916e-08 0.5 \ "" white darkgreen 4.945 -18.75 0 simundump kpool /kinetics/chain/kinetics/PLA2/PIP2-PLA2* 0 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom cyan darkgreen 7.3197 -18.292 0 simundump kenz /kinetics/chain/kinetics/PLA2/PIP2-PLA2*/kenz 0 0 0 0 0 75396 \ 3.6607e-05 44.16 11.04 0 0 "" red cyan "" 9.9655 -18.271 0 simundump kreac /kinetics/chain/kinetics/PLA2/PIP2-PLA2*/diff 0 0.001 0.001 \ "" white black 8.3197 -15.292 0 simundump kreac /kinetics/chain/kinetics/PLA2/PIP2-Ca-PLA2-act 0 1.5916e-07 \ 0.1 "" white darkgreen 5.903 -19.5 0 simundump kpool /kinetics/chain/kinetics/PLA2/PIP2-Ca-PLA2* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 7.6739 -19.896 0 simundump kenz /kinetics/chain/kinetics/PLA2/PIP2-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00011937 144 36 0 0 "" red cyan "" 10.028 -19.979 0 simundump kreac /kinetics/chain/kinetics/PLA2/PIP2-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 8.6739 -16.896 0 simundump kreac /kinetics/chain/kinetics/PLA2/DAG-Ca-PLA2-act 0 3.979e-08 4 \ "" white darkgreen 5.174 -21.834 0 simundump kpool /kinetics/chain/kinetics/PLA2/DAG-Ca-PLA2* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom pink darkgreen 7.8614 -22.479 0 simundump kenz /kinetics/chain/kinetics/PLA2/DAG-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00019895 240 60 0 0 "" red pink "" 10.049 -22.354 0 simundump kreac /kinetics/chain/kinetics/PLA2/DAG-Ca-PLA2*/diff 0 0.001 0.001 \ "" white black 8.8614 -19.479 0 simundump kpool /kinetics/chain/kinetics/PLA2/APC 0 -1e-12 30 30 2.2619e+06 \ 2.2619e+06 0 0 75396 4 /kinetics/dendgeom yellow darkgreen 7.7614 -21.963 0 simundump kreac /kinetics/chain/kinetics/PLA2/Degrade-AA 1 0.4 0 "" white \ darkgreen 9.8192 -17.288 0 simundump kpool /kinetics/chain/kinetics/PLA2/PLA2*-Ca 0 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange darkgreen 8.187 -24.687 0 simundump kenz /kinetics/chain/kinetics/PLA2/PLA2*-Ca/kenz 0 0 0 0 0 75396 \ 0.0003979 480 120 0 0 "" red orange "" 9.9186 -24.817 0 simundump kreac /kinetics/chain/kinetics/PLA2/PLA2*-Ca/diff 0 0.001 0.001 "" \ white black 9.187 -21.687 0 simundump kpool /kinetics/chain/kinetics/PLA2/PLA2* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange darkgreen 6.975 -26.851 0 simundump kreac /kinetics/chain/kinetics/PLA2/PLA2*/diff 0 0.001 0.001 "" \ white black 7.975 -23.851 0 simundump kreac /kinetics/chain/kinetics/PLA2/PLA2*-Ca-act 1 7.958e-05 0.1 "" \ white darkgreen 5.914 -24.752 0 simundump kreac /kinetics/chain/kinetics/PLA2/dephosphorylate-PLA2* 1 0.17 0 \ "" white darkgreen 2.307 -23.735 0 simundump kpool /kinetics/chain/kinetics/temp-PIP2 1 -1e-12 2.5 2.5 \ 1.8849e+05 1.8849e+05 0 0 75396 4 /kinetics/dendgeom green black 0.204 \ -19.047 0 simundump group /kinetics/chain/kinetics/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 31 -1 0 simundump kpool /kinetics/chain/kinetics/MAPK/craf-1 0 0 0.5 0.5 37698 37698 \ 0 0 75396 0 /kinetics/dendgeom pink brown 22 -4 0 simundump kpool /kinetics/chain/kinetics/MAPK/craf-1* 0 0 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom pink brown 25 -4 0 simundump kpool /kinetics/chain/kinetics/MAPK/MAPKK 0 0 0.5 0.5 37698 37698 0 \ 0 75396 0 /kinetics/dendgeom pink brown 22 -8 0 simundump kpool /kinetics/chain/kinetics/MAPK/MAPK 0 -1e-12 3.5999 3.5999 \ 2.7142e+05 2.7142e+05 0 0 75396 0 /kinetics/dendgeom pink brown 22 -11 0 simundump kreac /kinetics/chain/kinetics/MAPK/MAPK/diff 0 0.001 0.001 "" \ white black 23 -8 0 simundump kpool /kinetics/chain/kinetics/MAPK/craf-1** 1 0 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom hotpink brown 28 -4 0 simundump kpool /kinetics/chain/kinetics/MAPK/MAPK-tyr 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange brown 25 -11 0 simundump kreac /kinetics/chain/kinetics/MAPK/MAPK-tyr/diff 0 0.001 0.001 "" \ white black 26 -8 0 simundump kpool /kinetics/chain/kinetics/MAPK/MAPKK* 0 0 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom pink brown 29 -8 0 simundump kenz /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 75396 \ 0.00042973 1.2 0.3 0 0 "" red pink "" 24 -9 0 simundump kenz /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 75396 \ 0.00042973 1.2 0.3 0 0 "" red pink "" 29 -9 0 simundump kpool /kinetics/chain/kinetics/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom pink brown 25 -8 0 simundump kpool /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 21 -6 0 simundump kenz /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 0 0 \ 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 24 -6 0 simundump kenz /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 0 0 \ 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 27 -6 0 simundump kpool /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red brown 21 -7 0 simundump kenz /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 0 \ 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 24 -7 0 simundump kenz /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 0 \ 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 27 -7 0 simundump kreac /kinetics/chain/kinetics/Ras-act-craf 1 0.00013263 0.5 "" \ white black 19 -3 0 simundump group /kinetics/chain/kinetics/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 30.513 4.351 0 simundump kreac /kinetics/chain/kinetics/Ras/dephosph-GEF 1 1 0 "" white blue \ 25.07 5.881 0 simundump kpool /kinetics/chain/kinetics/Ras/inact-GEF 1 -1e-12 0.1 0.1 \ 7539.6 7539.6 0 0 75396 0 /kinetics/dendgeom hotpink blue 28.453 6.352 0 simundump kenz /kinetics/chain/kinetics/Ras/inact-GEF/basal_GEF_activity 0 0 \ 0 0 0 75396 1.313e-07 0.08 0.02 0 0 "" red hotpink "" 27 5 0 simundump kreac /kinetics/chain/kinetics/Ras/inact-GEF/diff 0 0.001 0.001 "" \ white black 29.453 9.352 0 simundump kpool /kinetics/chain/kinetics/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom hotpink blue 22.448 5.246 0 simundump kenz /kinetics/chain/kinetics/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 75396 \ 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 23.085 4.086 0 simundump kreac /kinetics/chain/kinetics/Ras/GEF*/diff 0 0.001 0.001 "" white \ black 23.448 8.246 0 simundump kpool /kinetics/chain/kinetics/Ras/GTP-Ras 1 0 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom orange blue 28.564 1.084 0 simundump kpool /kinetics/chain/kinetics/Ras/GDP-Ras 1 0 0.5 0.5 37698 37698 \ 0 0 75396 0 /kinetics/dendgeom pink blue 22.131 2.165 0 simundump kreac /kinetics/chain/kinetics/Ras/Ras-intrinsic-GTPase 1 1e-04 0 \ "" white blue 25.098 1.5 0 simundump kreac /kinetics/chain/kinetics/Ras/dephosph-GAP 1 0.1 0 "" white \ blue 20.023 3.524 0 simundump kpool /kinetics/chain/kinetics/Ras/GAP* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom red blue 17.35 2.349 0 simundump kreac /kinetics/chain/kinetics/Ras/GAP*/diff 0 0.001 0.001 "" white \ black 18.35 5.349 0 simundump kpool /kinetics/chain/kinetics/Ras/GAP 1 -1e-12 0.01 0.01 753.96 \ 753.96 0 0 75396 0 /kinetics/dendgeom red blue 22.655 0.338 0 simundump kenz /kinetics/chain/kinetics/Ras/GAP/GAP-inact-ras 1 0 0 0 0 75396 \ 0.00065634 40 10 0 0 "" red red "" 25.012 0.403 0 simundump kreac /kinetics/chain/kinetics/Ras/GAP/diff 0 0.001 0.001 "" white \ black 23.655 3.338 0 simundump kreac /kinetics/chain/kinetics/Ras/CaM-bind-GEF 1 0.0026526 1 "" \ white blue 18.486 9.679 0 simundump kpool /kinetics/chain/kinetics/Ras/CaM-GEF 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 21.345 7.58 0 simundump kenz /kinetics/chain/kinetics/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 0 0 \ 75396 1.3131e-05 0.4 0.1 0 0 "" red pink "" 21.022 6.657 0 simundump kreac /kinetics/chain/kinetics/Ras/CaM-GEF/diff 0 0.001 0.001 "" \ white black 22.345 10.58 0 simundump kpool /kinetics/chain/kinetics/Ca 1 -1e-12 0.095 0.095 7162.6 \ 7162.6 0 0 75396 4 /kinetics/dendgeom red black 1 -13 0 simundump kpool /kinetics/chain/kinetics/DAG 1 -1e-12 12.2 12.2 9.1983e+05 \ 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 16.718 -19.562 0 simundump kpool /kinetics/chain/kinetics/PKC-active 1 -1e-12 0.3 2.1196e-16 \ 1.5981e-11 22619 0 0 75396 2 /kinetics/dendgeom red black 16 -3 0 simundump kenz /kinetics/chain/kinetics/PKC-active/PKC-act-raf 1 0 0 0 0 \ 75396 3.979e-06 16 4 0 0 "" red yellow "" 22 -2 0 simundump kenz /kinetics/chain/kinetics/PKC-active/PKC-inact-GAP 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 20 1 0 simundump kenz /kinetics/chain/kinetics/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 25 8 0 simundump kenz /kinetics/chain/kinetics/PKC-active/phosph-AC2 1 0 0 0 0 75396 \ 0.00066667 16 4 0 0 "" red red "" 9.3178 -23.269 0 simundump kpool /kinetics/chain/kinetics/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom orange yellow 29 -11 0 simundump kenz /kinetics/chain/kinetics/MAPK*/MAPK* 0 0 0 0 0 75396 \ 2.5864e-05 40 10 0 0 "" red orange "" 4 -26 0 simundump kenz /kinetics/chain/kinetics/MAPK*/MAPK*-feedback 1 0 0 0 0 75396 \ 2.5864e-05 40 10 0 0 "" red orange "" 26 -2 0 simundump kreac /kinetics/chain/kinetics/MAPK*/diff 0 0.001 0.001 "" white \ black 30 -8 0 simundump kpool /kinetics/chain/kinetics/IP3 1 -1e-12 0.73 0.73 55039 55039 0 \ 0 75396 4 /kinetics/dendgeom pink black 15.226 -16.656 0 simundump kpool /kinetics/chain/kinetics/MKP-1 1 -1e-12 0.024 0.024 1809.5 \ 1809.5 0 0 75396 0 /kinetics/dendgeom hotpink black 21 -10 0 simundump kenz /kinetics/chain/kinetics/MKP-1/MKP1-tyr-deph 1 0 0 0 0 75396 \ 0.0019895 16 4 0 0 "" red hotpink "" 22 -9 0 simundump kenz /kinetics/chain/kinetics/MKP-1/MKP1-thr-deph 1 0 0 0 0 75396 \ 0.0019895 16 4 0 0 "" red hotpink "" 27 -9 0 simundump kreac /kinetics/chain/kinetics/MKP-1/diff 0 0.001 0.001 "" white \ black 22 -7 0 simundump kpool /kinetics/chain/kinetics/PPhosphatase2A 1 -1e-12 1 1 75396 \ 75396 0 0 75396 0 /kinetics/dendgeom hotpink yellow 25 -3 0 simundump kenz /kinetics/chain/kinetics/PPhosphatase2A/craf-deph 1 0 0 0 0 \ 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 24 -2 0 simundump kenz /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph 1 0 0 0 0 \ 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 27 -5 0 simundump kenz /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph-ser 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 24 -5 0 simundump kenz /kinetics/chain/kinetics/PPhosphatase2A/craf**-deph 1 0 0 0 0 \ 0.12566 2.5414e-05 24 6 0 0 "" red hotpink "" 28 -2 0 simundump kreac /kinetics/chain/kinetics/PPhosphatase2A/diff 0 0.001 0.001 "" \ white black 26 0 0 simundump group /kinetics/chain/kinetics/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 3 -9 0 simundump kpool /kinetics/chain/kinetics/CaM/CaM 1 -1e-12 20 20 1.5079e+06 \ 1.5079e+06 0 0 75396 0 /kinetics/dendgeom pink blue 2.983 -1.28 0 simundump kreac /kinetics/chain/kinetics/CaM/CaM/diff 0 0.001 0.001 "" white \ black 3.983 1.72 0 simundump kreac /kinetics/chain/kinetics/CaM/CaM-TR2-bind-Ca 1 1.2666e-08 72 \ "" white blue 5.162 -1.921 0 simundump kreac /kinetics/chain/kinetics/CaM/CaM-TR2-Ca2-bind-Ca 1 4.7748e-05 \ 10 "" white blue 4.158 -3.7747 0 simundump kreac /kinetics/chain/kinetics/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 10 \ "" white blue 2.6 -6.7404 0 simundump kpool /kinetics/chain/kinetics/CaM/CaM-Ca3 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 6.489 -5.603 0 simundump kreac /kinetics/chain/kinetics/CaM/CaM-Ca3/diff 0 0.001 0.001 "" \ white black 7.489 -2.603 0 simundump kpool /kinetics/chain/kinetics/CaM/CaM-TR2-Ca2 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 7.999 -2.7423 0 simundump kreac /kinetics/chain/kinetics/CaM/CaM-TR2-Ca2/diff 0 0.001 0.001 \ "" white black 8.999 0.2577 0 simundump kpool /kinetics/chain/kinetics/CaM/CaM-Ca4 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom blue blue 8 -8 0 simundump kreac /kinetics/chain/kinetics/CaM/CaM-Ca4/diff 0 0.001 0.001 "" \ white black 9 -5 0 simundump kreac /kinetics/chain/kinetics/Ras-act-unphosph-raf 0 7.958e-05 1 \ "" white black 20 -4 0 simundump kpool /kinetics/chain/kinetics/Ca_input 0 -1e-12 0.08 0.08 6031.7 \ 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black -6 -7 0 simundump kreac /kinetics/chain/kinetics/Ca_diff 0 2 2 "" white black -5 -12 \ 0 simundump group /kinetics/chain/kinetics[1] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 54 0 0 simundump group /kinetics/chain/kinetics[1]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 62.951 -3.7837 0 simundump kpool /kinetics/chain/kinetics[1]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 61.925 -10.489 0 simundump kreac /kinetics/chain/kinetics[1]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 62.925 -7.489 0 simundump kreac /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca 0 7.958e-06 0.5 \ "" white blue 61.925 -12.123 0 simundump kreac /kinetics/chain/kinetics[1]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 63.939 -11.306 0 simundump kreac /kinetics/chain/kinetics[1]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 62.203 -7.7467 0 simundump kreac /kinetics/chain/kinetics[1]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 63.383 -9.2638 0 simundump kreac /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca-AA 0 1.5916e-08 \ 0.1 "" white blue 65.212 -8.1843 0 simundump kreac /kinetics/chain/kinetics[1]/PKC/PKC-act-by-DAG-AA 0 2 0.2 "" \ white blue 67.249 -8.7678 0 simundump kpool /kinetics/chain/kinetics[1]/PKC/PKC-DAG-AA* 0 -1e-12 \ 4.9137e-18 4.9137e-18 3.7047e-13 3.7047e-13 0 0 75396 0 /kinetics/dendgeom \ cyan blue 66.601 -6.463 0 simundump kreac /kinetics/chain/kinetics[1]/PKC/PKC-DAG-AA*/diff 0 0.001 \ 0.001 "" white black 67.601 -3.463 0 simundump kpool /kinetics/chain/kinetics[1]/PKC/PKC-Ca-AA* 0 -1e-12 \ 1.7501e-16 1.7501e-16 1.3195e-11 1.3195e-11 0 0 75396 0 /kinetics/dendgeom \ orange blue 65.397 -5.7044 0 simundump kreac /kinetics/chain/kinetics[1]/PKC/PKC-Ca-AA*/diff 0 0.001 0.001 \ "" white black 66.397 -2.7044 0 simundump kpool /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb* 0 -1e-12 \ 1.3896e-17 1.3896e-17 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom \ pink blue 63.221 -5.471 0 simundump kreac /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb*/diff 0 0.001 \ 0.001 "" white black 64.221 -2.471 0 simundump kpool /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb* 0 -1e-12 \ 9.4351e-21 9.4351e-21 7.1137e-16 7.1137e-16 0 0 75396 0 /kinetics/dendgeom \ yellow blue 64.17 -6.4922 0 simundump kreac /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb*/diff 0 0.001 \ 0.001 "" white black 65.17 -3.4922 0 simundump kpool /kinetics/chain/kinetics[1]/PKC/PKC-basal* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom pink blue 61.254 -6.4338 0 simundump kreac /kinetics/chain/kinetics[1]/PKC/PKC-basal*/diff 0 0.001 0.001 \ "" white black 62.254 -3.4338 0 simundump kreac /kinetics/chain/kinetics[1]/PKC/PKC-basal-act 0 1 50 "" white \ blue 61.022 -8.9429 0 simundump kpool /kinetics/chain/kinetics[1]/PKC/PKC-AA* 0 -1e-12 1.8134e-17 \ 1.8134e-17 1.3672e-12 1.3672e-12 0 0 75396 0 /kinetics/dendgeom cyan blue \ 67.782 -5.1793 0 simundump kreac /kinetics/chain/kinetics[1]/PKC/PKC-AA*/diff 0 0.001 0.001 "" \ white black 68.782 -2.1793 0 simundump kreac /kinetics/chain/kinetics[1]/PKC/PKC-act-by-AA 0 1.5916e-09 \ 0.1 "" white blue 61.007 -13.865 0 simundump kpool /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG 0 -1e-12 \ 8.4632e-23 8.4632e-23 6.3809e-18 6.3809e-18 0 0 75396 0 /kinetics/dendgeom \ white blue 66.231 -10.197 0 simundump kreac /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG/diff 0 0.001 0.001 \ "" white black 67.231 -7.197 0 simundump kreac /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 62.99 -13.99 0 simundump kpool /kinetics/chain/kinetics[1]/PKC/PKC-DAG 0 -1e-12 1.161e-16 \ 1.161e-16 8.7535e-12 8.7535e-12 0 0 75396 0 /kinetics/dendgeom white blue \ 65.004 -13.086 0 simundump kreac /kinetics/chain/kinetics[1]/PKC/PKC-DAG/diff 0 0.001 0.001 "" \ white black 66.004 -10.086 0 simundump kreac /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG-AA 0 2.3874e-07 2 \ "" white blue 64.772 -14.953 0 simundump kpool /kinetics/chain/kinetics[1]/PKC/PKC-DAG-AA 0 -1e-12 \ 2.5188e-19 2.5188e-19 1.8991e-14 1.8991e-14 0 0 75396 0 /kinetics/dendgeom \ white blue 66.624 -11.773 0 simundump kreac /kinetics/chain/kinetics[1]/PKC/PKC-DAG-AA/diff 0 0.001 0.001 \ "" white black 67.624 -8.773 0 simundump kpool /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic 0 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom white blue 59.868 -11.403 0 simundump kreac /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic/diff 0 0.001 \ 0.001 "" white black 60.868 -8.403 0 simundump kpool /kinetics/chain/kinetics[1]/AA 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom darkgreen black 62.71 -21.338 0 simundump kreac /kinetics/chain/kinetics[1]/AA/diff 0 0.001 0.001 "" white \ black 63.71 -18.338 0 simundump group /kinetics/chain/kinetics[1]/PLA2 0 darkgreen black x 0 1 "" \ defaultfile defaultfile.g 0 0 0 58.643 -26.209 0 simundump kpool /kinetics/chain/kinetics[1]/PLA2/PLA2-cytosolic 0 -1e-12 \ 0.39999 0.39999 30158 30158 0 0 75396 0 /kinetics/dendgeom yellow darkgreen \ 54.176 -20.942 0 simundump kreac /kinetics/chain/kinetics[1]/PLA2/PLA2-cytosolic/diff 0 0.001 \ 0.001 "" white black 55.176 -17.942 0 simundump kreac /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca-act 0 1.3263e-05 0.1 \ "" white darkgreen 54.903 -23.104 0 simundump kpool /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom yellow darkgreen 57.278 -23.646 0 simundump kenz /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca*/kenz 0 0 0 0 0 75396 \ 1.7906e-05 21.6 5.4 0 0 "" red yellow "" 59.945 -23.667 0 simundump kreac /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca*/diff 0 0.001 0.001 \ "" white black 58.278 -20.646 0 simundump kreac /kinetics/chain/kinetics[1]/PLA2/PIP2-PLA2-act 0 1.5916e-08 \ 0.5 "" white darkgreen 54.945 -18.75 0 simundump kpool /kinetics/chain/kinetics[1]/PLA2/PIP2-PLA2* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 57.32 -18.292 0 simundump kenz /kinetics/chain/kinetics[1]/PLA2/PIP2-PLA2*/kenz 0 0 0 0 0 \ 75396 3.6607e-05 44.16 11.04 0 0 "" red cyan "" 59.965 -18.271 0 simundump kreac /kinetics/chain/kinetics[1]/PLA2/PIP2-PLA2*/diff 0 0.001 \ 0.001 "" white black 58.32 -15.292 0 simundump kreac /kinetics/chain/kinetics[1]/PLA2/PIP2-Ca-PLA2-act 0 \ 1.5916e-07 0.1 "" white darkgreen 55.903 -19.5 0 simundump kpool /kinetics/chain/kinetics[1]/PLA2/PIP2-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 57.674 -19.896 0 simundump kenz /kinetics/chain/kinetics[1]/PLA2/PIP2-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00011937 144 36 0 0 "" red cyan "" 60.028 -19.979 0 simundump kreac /kinetics/chain/kinetics[1]/PLA2/PIP2-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 58.674 -16.896 0 simundump kreac /kinetics/chain/kinetics[1]/PLA2/DAG-Ca-PLA2-act 0 3.979e-08 \ 4 "" white darkgreen 55.174 -21.834 0 simundump kpool /kinetics/chain/kinetics[1]/PLA2/DAG-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom pink darkgreen 57.861 -22.479 0 simundump kenz /kinetics/chain/kinetics[1]/PLA2/DAG-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00019895 240 60 0 0 "" red pink "" 60.049 -22.354 0 simundump kreac /kinetics/chain/kinetics[1]/PLA2/DAG-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 58.861 -19.479 0 simundump kpool /kinetics/chain/kinetics[1]/PLA2/APC 0 -1e-12 30 30 \ 2.2619e+06 2.2619e+06 0 0 75396 4 /kinetics/dendgeom yellow darkgreen \ 57.761 -21.963 0 simundump kreac /kinetics/chain/kinetics[1]/PLA2/Degrade-AA 1 0.4 0 "" white \ darkgreen 59.819 -17.288 0 simundump kpool /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange darkgreen 58.187 -24.687 0 simundump kenz /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca/kenz 0 0 0 0 0 75396 \ 0.0003979 480 120 0 0 "" red orange "" 59.919 -24.817 0 simundump kreac /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca/diff 0 0.001 0.001 \ "" white black 59.187 -21.687 0 simundump kpool /kinetics/chain/kinetics[1]/PLA2/PLA2* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange darkgreen 56.975 -26.851 0 simundump kreac /kinetics/chain/kinetics[1]/PLA2/PLA2*/diff 0 0.001 0.001 "" \ white black 57.975 -23.851 0 simundump kreac /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca-act 1 7.958e-05 0.1 \ "" white darkgreen 55.914 -24.752 0 simundump kreac /kinetics/chain/kinetics[1]/PLA2/dephosphorylate-PLA2* 1 0.17 \ 0 "" white darkgreen 52.307 -23.735 0 simundump kpool /kinetics/chain/kinetics[1]/temp-PIP2 1 -1e-12 2.5 2.5 \ 1.8849e+05 1.8849e+05 0 0 75396 4 /kinetics/dendgeom green black 50.204 \ -19.047 0 simundump group /kinetics/chain/kinetics[1]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 81 -1 0 simundump kpool /kinetics/chain/kinetics[1]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 72 -4 0 simundump kpool /kinetics/chain/kinetics[1]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 75 -4 0 simundump kpool /kinetics/chain/kinetics[1]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 72 -8 0 simundump kpool /kinetics/chain/kinetics[1]/MAPK/MAPK 0 -1e-12 3.5999 3.5999 \ 2.7142e+05 2.7142e+05 0 0 75396 0 /kinetics/dendgeom pink brown 72 -11 0 simundump kreac /kinetics/chain/kinetics[1]/MAPK/MAPK/diff 0 0.001 0.001 "" \ white black 73 -8 0 simundump kpool /kinetics/chain/kinetics[1]/MAPK/craf-1** 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink brown 78 -4 0 simundump kpool /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr 1 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange brown 75 -11 0 simundump kreac /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr/diff 0 0.001 0.001 \ "" white black 76 -8 0 simundump kpool /kinetics/chain/kinetics[1]/MAPK/MAPKK* 0 0 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom pink brown 79 -8 0 simundump kenz /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 74 -9 0 simundump kenz /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 79 -9 0 simundump kpool /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 75 -8 0 simundump kpool /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 71 -6 0 simundump kenz /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 0 \ 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 74 -6 0 simundump kenz /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 0 \ 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 77 -6 0 simundump kpool /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red brown 71 -7 0 simundump kenz /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 74 -7 0 simundump kenz /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 77 -7 0 simundump kreac /kinetics/chain/kinetics[1]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 69 -3 0 simundump group /kinetics/chain/kinetics[1]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 80.513 4.351 0 simundump kreac /kinetics/chain/kinetics[1]/Ras/dephosph-GEF 1 1 0 "" white \ blue 75.07 5.881 0 simundump kpool /kinetics/chain/kinetics[1]/Ras/inact-GEF 1 -1e-12 0.1 0.1 \ 7539.6 7539.6 0 0 75396 0 /kinetics/dendgeom hotpink blue 78.453 6.352 0 simundump kenz /kinetics/chain/kinetics[1]/Ras/inact-GEF/basal_GEF_activity 0 \ 0 0 0 0 75396 1.313e-07 0.08 0.02 0 0 "" red hotpink "" 77 5 0 simundump kreac /kinetics/chain/kinetics[1]/Ras/inact-GEF/diff 0 0.001 0.001 \ "" white black 79.453 9.352 0 simundump kpool /kinetics/chain/kinetics[1]/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 72.448 5.246 0 simundump kenz /kinetics/chain/kinetics[1]/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 \ 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 73.085 4.086 0 simundump kreac /kinetics/chain/kinetics[1]/Ras/GEF*/diff 0 0.001 0.001 "" \ white black 73.448 8.246 0 simundump kpool /kinetics/chain/kinetics[1]/Ras/GTP-Ras 1 0 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange blue 78.564 1.084 0 simundump kpool /kinetics/chain/kinetics[1]/Ras/GDP-Ras 1 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink blue 72.131 2.165 0 simundump kreac /kinetics/chain/kinetics[1]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 75.098 1.5 0 simundump kreac /kinetics/chain/kinetics[1]/Ras/dephosph-GAP 1 0.1 0 "" white \ blue 70.023 3.524 0 simundump kpool /kinetics/chain/kinetics[1]/Ras/GAP* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red blue 67.35 2.349 0 simundump kreac /kinetics/chain/kinetics[1]/Ras/GAP*/diff 0 0.001 0.001 "" \ white black 68.35 5.349 0 simundump kpool /kinetics/chain/kinetics[1]/Ras/GAP 1 -1e-12 0.01 0.01 753.96 \ 753.96 0 0 75396 0 /kinetics/dendgeom red blue 72.655 0.338 0 simundump kenz /kinetics/chain/kinetics[1]/Ras/GAP/GAP-inact-ras 1 0 0 0 0 \ 75396 0.00065634 40 10 0 0 "" red red "" 75.012 0.403 0 simundump kreac /kinetics/chain/kinetics[1]/Ras/GAP/diff 0 0.001 0.001 "" \ white black 73.655 3.338 0 simundump kreac /kinetics/chain/kinetics[1]/Ras/CaM-bind-GEF 1 0.0026526 1 "" \ white blue 68.486 9.679 0 simundump kpool /kinetics/chain/kinetics[1]/Ras/CaM-GEF 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 71.345 7.58 0 simundump kenz /kinetics/chain/kinetics[1]/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 \ 0 0 75396 1.3131e-05 0.4 0.1 0 0 "" red pink "" 71.022 6.657 0 simundump kreac /kinetics/chain/kinetics[1]/Ras/CaM-GEF/diff 0 0.001 0.001 "" \ white black 72.345 10.58 0 simundump kpool /kinetics/chain/kinetics[1]/Ca 1 -1e-12 0.095 0.095 7162.6 \ 7162.6 0 0 75396 4 /kinetics/dendgeom red black 51 -13 0 simundump kpool /kinetics/chain/kinetics[1]/DAG 1 -1e-12 12.2 12.2 9.1983e+05 \ 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 66.718 -19.562 0 simundump kpool /kinetics/chain/kinetics[1]/PKC-active 1 -1e-12 0.3 \ 2.1196e-16 1.5981e-11 22619 0 0 75396 2 /kinetics/dendgeom red black 66 -3 \ 0 simundump kenz /kinetics/chain/kinetics[1]/PKC-active/PKC-act-raf 1 0 0 0 0 \ 75396 3.979e-06 16 4 0 0 "" red yellow "" 72 -2 0 simundump kenz /kinetics/chain/kinetics[1]/PKC-active/PKC-inact-GAP 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 70 1 0 simundump kenz /kinetics/chain/kinetics[1]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 75 8 0 simundump kenz /kinetics/chain/kinetics[1]/PKC-active/phosph-AC2 1 0 0 0 0 \ 75396 0.00066667 16 4 0 0 "" red red "" 59.318 -23.269 0 simundump kpool /kinetics/chain/kinetics[1]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 79 -11 0 simundump kenz /kinetics/chain/kinetics[1]/MAPK*/MAPK* 0 0 0 0 0 75396 \ 2.5864e-05 40 10 0 0 "" red orange "" 54 -26 0 simundump kenz /kinetics/chain/kinetics[1]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange "" 76 -2 0 simundump kreac /kinetics/chain/kinetics[1]/MAPK*/diff 0 0.001 0.001 "" white \ black 80 -8 0 simundump kpool /kinetics/chain/kinetics[1]/IP3 1 -1e-12 0.73 0.73 55039 \ 55039 0 0 75396 4 /kinetics/dendgeom pink black 65.226 -16.656 0 simundump kpool /kinetics/chain/kinetics[1]/MKP-1 1 -1e-12 0.024 0.024 1809.5 \ 1809.5 0 0 75396 0 /kinetics/dendgeom hotpink black 71 -10 0 simundump kenz /kinetics/chain/kinetics[1]/MKP-1/MKP1-tyr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 72 -9 0 simundump kenz /kinetics/chain/kinetics[1]/MKP-1/MKP1-thr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 77 -9 0 simundump kreac /kinetics/chain/kinetics[1]/MKP-1/diff 0 0.001 0.001 "" white \ black 72 -7 0 simundump kpool /kinetics/chain/kinetics[1]/PPhosphatase2A 1 -1e-12 1 1 75396 \ 75396 0 0 75396 0 /kinetics/dendgeom hotpink yellow 75 -3 0 simundump kenz /kinetics/chain/kinetics[1]/PPhosphatase2A/craf-deph 1 0 0 0 0 \ 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 74 -2 0 simundump kenz /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 77 -5 0 simundump kenz /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph-ser 1 0 \ 0 0 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 74 -5 0 simundump kenz /kinetics/chain/kinetics[1]/PPhosphatase2A/craf**-deph 1 0 0 0 \ 0 0.12566 2.5414e-05 24 6 0 0 "" red hotpink "" 78 -2 0 simundump kreac /kinetics/chain/kinetics[1]/PPhosphatase2A/diff 0 0.001 0.001 \ "" white black 76 0 0 simundump group /kinetics/chain/kinetics[1]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 53 -9 0 simundump kpool /kinetics/chain/kinetics[1]/CaM/CaM 1 -1e-12 20 20 1.5079e+06 \ 1.5079e+06 0 0 75396 0 /kinetics/dendgeom pink blue 52.983 -1.28 0 simundump kreac /kinetics/chain/kinetics[1]/CaM/CaM/diff 0 0.001 0.001 "" \ white black 53.983 1.72 0 simundump kreac /kinetics/chain/kinetics[1]/CaM/CaM-TR2-bind-Ca 1 1.2666e-08 \ 72 "" white blue 55.162 -1.921 0 simundump kreac /kinetics/chain/kinetics[1]/CaM/CaM-TR2-Ca2-bind-Ca 1 \ 4.7748e-05 10 "" white blue 54.158 -3.7747 0 simundump kreac /kinetics/chain/kinetics[1]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 52.6 -6.7404 0 simundump kpool /kinetics/chain/kinetics[1]/CaM/CaM-Ca3 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 56.489 -5.603 0 simundump kreac /kinetics/chain/kinetics[1]/CaM/CaM-Ca3/diff 0 0.001 0.001 "" \ white black 57.489 -2.603 0 simundump kpool /kinetics/chain/kinetics[1]/CaM/CaM-TR2-Ca2 1 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 57.999 -2.7423 0 simundump kreac /kinetics/chain/kinetics[1]/CaM/CaM-TR2-Ca2/diff 0 0.001 \ 0.001 "" white black 58.999 0.2577 0 simundump kpool /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom blue blue 58 -8 0 simundump kreac /kinetics/chain/kinetics[1]/CaM/CaM-Ca4/diff 0 0.001 0.001 "" \ white black 59 -5 0 simundump kreac /kinetics/chain/kinetics[1]/Ras-act-unphosph-raf 0 7.958e-05 \ 1 "" white black 70 -4 0 simundump kpool /kinetics/chain/kinetics[1]/Ca_input 0 -1e-12 0.08 0.08 \ 6031.7 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 44 -7 0 simundump kreac /kinetics/chain/kinetics[1]/Ca_diff 0 2 2 "" white black 45 \ -12 0 simundump group /kinetics/chain/kinetics[2] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 104 0 0 simundump group /kinetics/chain/kinetics[2]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 112.95 -3.7837 0 simundump kpool /kinetics/chain/kinetics[2]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 111.92 -10.489 0 simundump kreac /kinetics/chain/kinetics[2]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 112.92 -7.489 0 simundump kreac /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca 0 7.958e-06 0.5 \ "" white blue 111.92 -12.123 0 simundump kreac /kinetics/chain/kinetics[2]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 113.94 -11.306 0 simundump kreac /kinetics/chain/kinetics[2]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 112.2 -7.7467 0 simundump kreac /kinetics/chain/kinetics[2]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 113.38 -9.2638 0 simundump kreac /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca-AA 0 1.5916e-08 \ 0.1 "" white blue 115.21 -8.1843 0 simundump kreac /kinetics/chain/kinetics[2]/PKC/PKC-act-by-DAG-AA 0 2 0.2 "" \ white blue 117.25 -8.7678 0 simundump kpool /kinetics/chain/kinetics[2]/PKC/PKC-DAG-AA* 0 -1e-12 \ 4.9137e-18 4.9137e-18 3.7047e-13 3.7047e-13 0 0 75396 0 /kinetics/dendgeom \ cyan blue 116.6 -6.463 0 simundump kreac /kinetics/chain/kinetics[2]/PKC/PKC-DAG-AA*/diff 0 0.001 \ 0.001 "" white black 117.6 -3.463 0 simundump kpool /kinetics/chain/kinetics[2]/PKC/PKC-Ca-AA* 0 -1e-12 \ 1.7501e-16 1.7501e-16 1.3195e-11 1.3195e-11 0 0 75396 0 /kinetics/dendgeom \ orange blue 115.4 -5.7044 0 simundump kreac /kinetics/chain/kinetics[2]/PKC/PKC-Ca-AA*/diff 0 0.001 0.001 \ "" white black 116.4 -2.7044 0 simundump kpool /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb* 0 -1e-12 \ 1.3896e-17 1.3896e-17 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom \ pink blue 113.22 -5.471 0 simundump kreac /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb*/diff 0 0.001 \ 0.001 "" white black 114.22 -2.471 0 simundump kpool /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb* 0 -1e-12 \ 9.4351e-21 9.4351e-21 7.1137e-16 7.1137e-16 0 0 75396 0 /kinetics/dendgeom \ yellow blue 114.17 -6.4922 0 simundump kreac /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb*/diff 0 0.001 \ 0.001 "" white black 115.17 -3.4922 0 simundump kpool /kinetics/chain/kinetics[2]/PKC/PKC-basal* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom pink blue 111.25 -6.4338 0 simundump kreac /kinetics/chain/kinetics[2]/PKC/PKC-basal*/diff 0 0.001 0.001 \ "" white black 112.25 -3.4338 0 simundump kreac /kinetics/chain/kinetics[2]/PKC/PKC-basal-act 0 1 50 "" white \ blue 111.02 -8.9429 0 simundump kpool /kinetics/chain/kinetics[2]/PKC/PKC-AA* 0 -1e-12 1.8134e-17 \ 1.8134e-17 1.3672e-12 1.3672e-12 0 0 75396 0 /kinetics/dendgeom cyan blue \ 117.78 -5.1793 0 simundump kreac /kinetics/chain/kinetics[2]/PKC/PKC-AA*/diff 0 0.001 0.001 "" \ white black 118.78 -2.1793 0 simundump kreac /kinetics/chain/kinetics[2]/PKC/PKC-act-by-AA 0 1.5916e-09 \ 0.1 "" white blue 111.01 -13.865 0 simundump kpool /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG 0 -1e-12 \ 8.4632e-23 8.4632e-23 6.3809e-18 6.3809e-18 0 0 75396 0 /kinetics/dendgeom \ white blue 116.23 -10.197 0 simundump kreac /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG/diff 0 0.001 0.001 \ "" white black 117.23 -7.197 0 simundump kreac /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 112.99 -13.99 0 simundump kpool /kinetics/chain/kinetics[2]/PKC/PKC-DAG 0 -1e-12 1.161e-16 \ 1.161e-16 8.7535e-12 8.7535e-12 0 0 75396 0 /kinetics/dendgeom white blue \ 115 -13.086 0 simundump kreac /kinetics/chain/kinetics[2]/PKC/PKC-DAG/diff 0 0.001 0.001 "" \ white black 116 -10.086 0 simundump kreac /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG-AA 0 2.3874e-07 2 \ "" white blue 114.77 -14.953 0 simundump kpool /kinetics/chain/kinetics[2]/PKC/PKC-DAG-AA 0 -1e-12 \ 2.5188e-19 2.5188e-19 1.8991e-14 1.8991e-14 0 0 75396 0 /kinetics/dendgeom \ white blue 116.62 -11.773 0 simundump kreac /kinetics/chain/kinetics[2]/PKC/PKC-DAG-AA/diff 0 0.001 0.001 \ "" white black 117.62 -8.773 0 simundump kpool /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic 0 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom white blue 109.87 -11.403 0 simundump kreac /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic/diff 0 0.001 \ 0.001 "" white black 110.87 -8.403 0 simundump kpool /kinetics/chain/kinetics[2]/AA 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom darkgreen black 112.71 -21.338 0 simundump kreac /kinetics/chain/kinetics[2]/AA/diff 0 0.001 0.001 "" white \ black 113.71 -18.338 0 simundump group /kinetics/chain/kinetics[2]/PLA2 0 darkgreen black x 0 1 "" \ defaultfile defaultfile.g 0 0 0 108.64 -26.209 0 simundump kpool /kinetics/chain/kinetics[2]/PLA2/PLA2-cytosolic 0 -1e-12 \ 0.39999 0.39999 30158 30158 0 0 75396 0 /kinetics/dendgeom yellow darkgreen \ 104.18 -20.942 0 simundump kreac /kinetics/chain/kinetics[2]/PLA2/PLA2-cytosolic/diff 0 0.001 \ 0.001 "" white black 105.18 -17.942 0 simundump kreac /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca-act 0 1.3263e-05 0.1 \ "" white darkgreen 104.9 -23.104 0 simundump kpool /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom yellow darkgreen 107.28 -23.646 0 simundump kenz /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca*/kenz 0 0 0 0 0 75396 \ 1.7906e-05 21.6 5.4 0 0 "" red yellow "" 109.94 -23.667 0 simundump kreac /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca*/diff 0 0.001 0.001 \ "" white black 108.28 -20.646 0 simundump kreac /kinetics/chain/kinetics[2]/PLA2/PIP2-PLA2-act 0 1.5916e-08 \ 0.5 "" white darkgreen 104.94 -18.75 0 simundump kpool /kinetics/chain/kinetics[2]/PLA2/PIP2-PLA2* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 107.32 -18.292 0 simundump kenz /kinetics/chain/kinetics[2]/PLA2/PIP2-PLA2*/kenz 0 0 0 0 0 \ 75396 3.6607e-05 44.16 11.04 0 0 "" red cyan "" 109.97 -18.271 0 simundump kreac /kinetics/chain/kinetics[2]/PLA2/PIP2-PLA2*/diff 0 0.001 \ 0.001 "" white black 108.32 -15.292 0 simundump kreac /kinetics/chain/kinetics[2]/PLA2/PIP2-Ca-PLA2-act 0 \ 1.5916e-07 0.1 "" white darkgreen 105.9 -19.5 0 simundump kpool /kinetics/chain/kinetics[2]/PLA2/PIP2-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 107.67 -19.896 0 simundump kenz /kinetics/chain/kinetics[2]/PLA2/PIP2-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00011937 144 36 0 0 "" red cyan "" 110.03 -19.979 0 simundump kreac /kinetics/chain/kinetics[2]/PLA2/PIP2-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 108.67 -16.896 0 simundump kreac /kinetics/chain/kinetics[2]/PLA2/DAG-Ca-PLA2-act 0 3.979e-08 \ 4 "" white darkgreen 105.17 -21.834 0 simundump kpool /kinetics/chain/kinetics[2]/PLA2/DAG-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom pink darkgreen 107.86 -22.479 0 simundump kenz /kinetics/chain/kinetics[2]/PLA2/DAG-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00019895 240 60 0 0 "" red pink "" 110.05 -22.354 0 simundump kreac /kinetics/chain/kinetics[2]/PLA2/DAG-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 108.86 -19.479 0 simundump kpool /kinetics/chain/kinetics[2]/PLA2/APC 0 -1e-12 30 30 \ 2.2619e+06 2.2619e+06 0 0 75396 4 /kinetics/dendgeom yellow darkgreen \ 107.76 -21.963 0 simundump kreac /kinetics/chain/kinetics[2]/PLA2/Degrade-AA 1 0.4 0 "" white \ darkgreen 109.82 -17.288 0 simundump kpool /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange darkgreen 108.19 -24.687 0 simundump kenz /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca/kenz 0 0 0 0 0 75396 \ 0.0003979 480 120 0 0 "" red orange "" 109.92 -24.817 0 simundump kreac /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca/diff 0 0.001 0.001 \ "" white black 109.19 -21.687 0 simundump kpool /kinetics/chain/kinetics[2]/PLA2/PLA2* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange darkgreen 106.97 -26.851 0 simundump kreac /kinetics/chain/kinetics[2]/PLA2/PLA2*/diff 0 0.001 0.001 "" \ white black 107.97 -23.851 0 simundump kreac /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca-act 1 7.958e-05 0.1 \ "" white darkgreen 105.91 -24.752 0 simundump kreac /kinetics/chain/kinetics[2]/PLA2/dephosphorylate-PLA2* 1 0.17 \ 0 "" white darkgreen 102.31 -23.735 0 simundump kpool /kinetics/chain/kinetics[2]/temp-PIP2 1 -1e-12 2.5 2.5 \ 1.8849e+05 1.8849e+05 0 0 75396 4 /kinetics/dendgeom green black 100.2 \ -19.047 0 simundump group /kinetics/chain/kinetics[2]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 131 -1 0 simundump kpool /kinetics/chain/kinetics[2]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 122 -4 0 simundump kpool /kinetics/chain/kinetics[2]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 125 -4 0 simundump kpool /kinetics/chain/kinetics[2]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 122 -8 0 simundump kpool /kinetics/chain/kinetics[2]/MAPK/MAPK 0 -1e-12 3.5999 3.5999 \ 2.7142e+05 2.7142e+05 0 0 75396 0 /kinetics/dendgeom pink brown 122 -11 0 simundump kreac /kinetics/chain/kinetics[2]/MAPK/MAPK/diff 0 0.001 0.001 "" \ white black 123 -8 0 simundump kpool /kinetics/chain/kinetics[2]/MAPK/craf-1** 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink brown 128 -4 0 simundump kpool /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr 1 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange brown 125 -11 0 simundump kreac /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr/diff 0 0.001 0.001 \ "" white black 126 -8 0 simundump kpool /kinetics/chain/kinetics[2]/MAPK/MAPKK* 0 0 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom pink brown 129 -8 0 simundump kenz /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 124 -9 0 simundump kenz /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 129 -9 0 simundump kpool /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 125 -8 0 simundump kpool /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 121 -6 0 simundump kenz /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 0 \ 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 124 -6 0 simundump kenz /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 0 \ 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 127 -6 0 simundump kpool /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red brown 121 -7 0 simundump kenz /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 124 -7 0 simundump kenz /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 127 -7 0 simundump kreac /kinetics/chain/kinetics[2]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 119 -3 0 simundump group /kinetics/chain/kinetics[2]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 130.51 4.351 0 simundump kreac /kinetics/chain/kinetics[2]/Ras/dephosph-GEF 1 1 0 "" white \ blue 125.07 5.881 0 simundump kpool /kinetics/chain/kinetics[2]/Ras/inact-GEF 1 -1e-12 0.1 0.1 \ 7539.6 7539.6 0 0 75396 0 /kinetics/dendgeom hotpink blue 128.45 6.352 0 simundump kenz /kinetics/chain/kinetics[2]/Ras/inact-GEF/basal_GEF_activity 0 \ 0 0 0 0 75396 1.313e-07 0.08 0.02 0 0 "" red hotpink "" 127 5 0 simundump kreac /kinetics/chain/kinetics[2]/Ras/inact-GEF/diff 0 0.001 0.001 \ "" white black 129.45 9.352 0 simundump kpool /kinetics/chain/kinetics[2]/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 122.45 5.246 0 simundump kenz /kinetics/chain/kinetics[2]/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 \ 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 123.08 4.086 0 simundump kreac /kinetics/chain/kinetics[2]/Ras/GEF*/diff 0 0.001 0.001 "" \ white black 123.45 8.246 0 simundump kpool /kinetics/chain/kinetics[2]/Ras/GTP-Ras 1 0 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange blue 128.56 1.084 0 simundump kpool /kinetics/chain/kinetics[2]/Ras/GDP-Ras 1 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink blue 122.13 2.165 0 simundump kreac /kinetics/chain/kinetics[2]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 125.1 1.5 0 simundump kreac /kinetics/chain/kinetics[2]/Ras/dephosph-GAP 1 0.1 0 "" white \ blue 120.02 3.524 0 simundump kpool /kinetics/chain/kinetics[2]/Ras/GAP* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red blue 117.35 2.349 0 simundump kreac /kinetics/chain/kinetics[2]/Ras/GAP*/diff 0 0.001 0.001 "" \ white black 118.35 5.349 0 simundump kpool /kinetics/chain/kinetics[2]/Ras/GAP 1 -1e-12 0.01 0.01 753.96 \ 753.96 0 0 75396 0 /kinetics/dendgeom red blue 122.65 0.338 0 simundump kenz /kinetics/chain/kinetics[2]/Ras/GAP/GAP-inact-ras 1 0 0 0 0 \ 75396 0.00065634 40 10 0 0 "" red red "" 125.01 0.403 0 simundump kreac /kinetics/chain/kinetics[2]/Ras/GAP/diff 0 0.001 0.001 "" \ white black 123.65 3.338 0 simundump kreac /kinetics/chain/kinetics[2]/Ras/CaM-bind-GEF 1 0.0026526 1 "" \ white blue 118.49 9.679 0 simundump kpool /kinetics/chain/kinetics[2]/Ras/CaM-GEF 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 121.35 7.58 0 simundump kenz /kinetics/chain/kinetics[2]/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 \ 0 0 75396 1.3131e-05 0.4 0.1 0 0 "" red pink "" 121.02 6.657 0 simundump kreac /kinetics/chain/kinetics[2]/Ras/CaM-GEF/diff 0 0.001 0.001 "" \ white black 122.35 10.58 0 simundump kpool /kinetics/chain/kinetics[2]/Ca 1 -1e-12 0.095 0.095 7162.6 \ 7162.6 0 0 75396 4 /kinetics/dendgeom red black 101 -13 0 simundump kpool /kinetics/chain/kinetics[2]/DAG 1 -1e-12 12.2 12.2 9.1983e+05 \ 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 116.72 -19.562 0 simundump kpool /kinetics/chain/kinetics[2]/PKC-active 1 -1e-12 0.3 \ 2.1196e-16 1.5981e-11 22619 0 0 75396 2 /kinetics/dendgeom red black 116 -3 \ 0 simundump kenz /kinetics/chain/kinetics[2]/PKC-active/PKC-act-raf 1 0 0 0 0 \ 75396 3.979e-06 16 4 0 0 "" red yellow "" 122 -2 0 simundump kenz /kinetics/chain/kinetics[2]/PKC-active/PKC-inact-GAP 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 120 1 0 simundump kenz /kinetics/chain/kinetics[2]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 125 8 0 simundump kenz /kinetics/chain/kinetics[2]/PKC-active/phosph-AC2 1 0 0 0 0 \ 75396 0.00066667 16 4 0 0 "" red red "" 109.32 -23.269 0 simundump kpool /kinetics/chain/kinetics[2]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 129 -11 0 simundump kenz /kinetics/chain/kinetics[2]/MAPK*/MAPK* 0 0 0 0 0 75396 \ 2.5864e-05 40 10 0 0 "" red orange "" 104 -26 0 simundump kenz /kinetics/chain/kinetics[2]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange "" 126 -2 0 simundump kreac /kinetics/chain/kinetics[2]/MAPK*/diff 0 0.001 0.001 "" white \ black 130 -8 0 simundump kpool /kinetics/chain/kinetics[2]/IP3 1 -1e-12 0.73 0.73 55039 \ 55039 0 0 75396 4 /kinetics/dendgeom pink black 115.23 -16.656 0 simundump kpool /kinetics/chain/kinetics[2]/MKP-1 1 -1e-12 0.024 0.024 1809.5 \ 1809.5 0 0 75396 0 /kinetics/dendgeom hotpink black 121 -10 0 simundump kenz /kinetics/chain/kinetics[2]/MKP-1/MKP1-tyr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 122 -9 0 simundump kenz /kinetics/chain/kinetics[2]/MKP-1/MKP1-thr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 127 -9 0 simundump kreac /kinetics/chain/kinetics[2]/MKP-1/diff 0 0.001 0.001 "" white \ black 122 -7 0 simundump kpool /kinetics/chain/kinetics[2]/PPhosphatase2A 1 -1e-12 1 1 75396 \ 75396 0 0 75396 0 /kinetics/dendgeom hotpink yellow 125 -3 0 simundump kenz /kinetics/chain/kinetics[2]/PPhosphatase2A/craf-deph 1 0 0 0 0 \ 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 124 -2 0 simundump kenz /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 127 -5 0 simundump kenz /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph-ser 1 0 \ 0 0 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 124 -5 0 simundump kenz /kinetics/chain/kinetics[2]/PPhosphatase2A/craf**-deph 1 0 0 0 \ 0 0.12566 2.5414e-05 24 6 0 0 "" red hotpink "" 128 -2 0 simundump kreac /kinetics/chain/kinetics[2]/PPhosphatase2A/diff 0 0.001 0.001 \ "" white black 126 0 0 simundump group /kinetics/chain/kinetics[2]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 103 -9 0 simundump kpool /kinetics/chain/kinetics[2]/CaM/CaM 1 -1e-12 20 20 1.5079e+06 \ 1.5079e+06 0 0 75396 0 /kinetics/dendgeom pink blue 102.98 -1.28 0 simundump kreac /kinetics/chain/kinetics[2]/CaM/CaM/diff 0 0.001 0.001 "" \ white black 103.98 1.72 0 simundump kreac /kinetics/chain/kinetics[2]/CaM/CaM-TR2-bind-Ca 1 1.2666e-08 \ 72 "" white blue 105.16 -1.921 0 simundump kreac /kinetics/chain/kinetics[2]/CaM/CaM-TR2-Ca2-bind-Ca 1 \ 4.7748e-05 10 "" white blue 104.16 -3.7747 0 simundump kreac /kinetics/chain/kinetics[2]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 102.6 -6.7404 0 simundump kpool /kinetics/chain/kinetics[2]/CaM/CaM-Ca3 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 106.49 -5.603 0 simundump kreac /kinetics/chain/kinetics[2]/CaM/CaM-Ca3/diff 0 0.001 0.001 "" \ white black 107.49 -2.603 0 simundump kpool /kinetics/chain/kinetics[2]/CaM/CaM-TR2-Ca2 1 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 108 -2.7423 0 simundump kreac /kinetics/chain/kinetics[2]/CaM/CaM-TR2-Ca2/diff 0 0.001 \ 0.001 "" white black 109 0.2577 0 simundump kpool /kinetics/chain/kinetics[2]/CaM/CaM-Ca4 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom blue blue 108 -8 0 simundump kreac /kinetics/chain/kinetics[2]/CaM/CaM-Ca4/diff 0 0.001 0.001 "" \ white black 109 -5 0 simundump kreac /kinetics/chain/kinetics[2]/Ras-act-unphosph-raf 0 7.958e-05 \ 1 "" white black 120 -4 0 simundump kpool /kinetics/chain/kinetics[2]/Ca_input 0 -1e-12 0.08 0.08 \ 6031.7 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 94 -7 0 simundump kreac /kinetics/chain/kinetics[2]/Ca_diff 0 2 2 "" white black 95 \ -12 0 simundump group /kinetics/chain/kinetics[3] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 154 0 0 simundump group /kinetics/chain/kinetics[3]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 162.95 -3.7837 0 simundump kpool /kinetics/chain/kinetics[3]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 161.92 -10.489 0 simundump kreac /kinetics/chain/kinetics[3]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 162.92 -7.489 0 simundump kreac /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca 0 7.958e-06 0.5 \ "" white blue 161.92 -12.123 0 simundump kreac /kinetics/chain/kinetics[3]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 163.94 -11.306 0 simundump kreac /kinetics/chain/kinetics[3]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 162.2 -7.7467 0 simundump kreac /kinetics/chain/kinetics[3]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 163.38 -9.2638 0 simundump kreac /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca-AA 0 1.5916e-08 \ 0.1 "" white blue 165.21 -8.1843 0 simundump kreac /kinetics/chain/kinetics[3]/PKC/PKC-act-by-DAG-AA 0 2 0.2 "" \ white blue 167.25 -8.7678 0 simundump kpool /kinetics/chain/kinetics[3]/PKC/PKC-DAG-AA* 0 -1e-12 \ 4.9137e-18 4.9137e-18 3.7047e-13 3.7047e-13 0 0 75396 0 /kinetics/dendgeom \ cyan blue 166.6 -6.463 0 simundump kreac /kinetics/chain/kinetics[3]/PKC/PKC-DAG-AA*/diff 0 0.001 \ 0.001 "" white black 167.6 -3.463 0 simundump kpool /kinetics/chain/kinetics[3]/PKC/PKC-Ca-AA* 0 -1e-12 \ 1.7501e-16 1.7501e-16 1.3195e-11 1.3195e-11 0 0 75396 0 /kinetics/dendgeom \ orange blue 165.4 -5.7044 0 simundump kreac /kinetics/chain/kinetics[3]/PKC/PKC-Ca-AA*/diff 0 0.001 0.001 \ "" white black 166.4 -2.7044 0 simundump kpool /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb* 0 -1e-12 \ 1.3896e-17 1.3896e-17 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom \ pink blue 163.22 -5.471 0 simundump kreac /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb*/diff 0 0.001 \ 0.001 "" white black 164.22 -2.471 0 simundump kpool /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb* 0 -1e-12 \ 9.4351e-21 9.4351e-21 7.1137e-16 7.1137e-16 0 0 75396 0 /kinetics/dendgeom \ yellow blue 164.17 -6.4922 0 simundump kreac /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb*/diff 0 0.001 \ 0.001 "" white black 165.17 -3.4922 0 simundump kpool /kinetics/chain/kinetics[3]/PKC/PKC-basal* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom pink blue 161.25 -6.4338 0 simundump kreac /kinetics/chain/kinetics[3]/PKC/PKC-basal*/diff 0 0.001 0.001 \ "" white black 162.25 -3.4338 0 simundump kreac /kinetics/chain/kinetics[3]/PKC/PKC-basal-act 0 1 50 "" white \ blue 161.02 -8.9429 0 simundump kpool /kinetics/chain/kinetics[3]/PKC/PKC-AA* 0 -1e-12 1.8134e-17 \ 1.8134e-17 1.3672e-12 1.3672e-12 0 0 75396 0 /kinetics/dendgeom cyan blue \ 167.78 -5.1793 0 simundump kreac /kinetics/chain/kinetics[3]/PKC/PKC-AA*/diff 0 0.001 0.001 "" \ white black 168.78 -2.1793 0 simundump kreac /kinetics/chain/kinetics[3]/PKC/PKC-act-by-AA 0 1.5916e-09 \ 0.1 "" white blue 161.01 -13.865 0 simundump kpool /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG 0 -1e-12 \ 8.4632e-23 8.4632e-23 6.3809e-18 6.3809e-18 0 0 75396 0 /kinetics/dendgeom \ white blue 166.23 -10.197 0 simundump kreac /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG/diff 0 0.001 0.001 \ "" white black 167.23 -7.197 0 simundump kreac /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 162.99 -13.99 0 simundump kpool /kinetics/chain/kinetics[3]/PKC/PKC-DAG 0 -1e-12 1.161e-16 \ 1.161e-16 8.7535e-12 8.7535e-12 0 0 75396 0 /kinetics/dendgeom white blue \ 165 -13.086 0 simundump kreac /kinetics/chain/kinetics[3]/PKC/PKC-DAG/diff 0 0.001 0.001 "" \ white black 166 -10.086 0 simundump kreac /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG-AA 0 2.3874e-07 2 \ "" white blue 164.77 -14.953 0 simundump kpool /kinetics/chain/kinetics[3]/PKC/PKC-DAG-AA 0 -1e-12 \ 2.5188e-19 2.5188e-19 1.8991e-14 1.8991e-14 0 0 75396 0 /kinetics/dendgeom \ white blue 166.62 -11.773 0 simundump kreac /kinetics/chain/kinetics[3]/PKC/PKC-DAG-AA/diff 0 0.001 0.001 \ "" white black 167.62 -8.773 0 simundump kpool /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic 0 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom white blue 159.87 -11.403 0 simundump kreac /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic/diff 0 0.001 \ 0.001 "" white black 160.87 -8.403 0 simundump kpool /kinetics/chain/kinetics[3]/AA 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom darkgreen black 162.71 -21.338 0 simundump kreac /kinetics/chain/kinetics[3]/AA/diff 0 0.001 0.001 "" white \ black 163.71 -18.338 0 simundump group /kinetics/chain/kinetics[3]/PLA2 0 darkgreen black x 0 1 "" \ defaultfile defaultfile.g 0 0 0 158.64 -26.209 0 simundump kpool /kinetics/chain/kinetics[3]/PLA2/PLA2-cytosolic 0 -1e-12 \ 0.39999 0.39999 30158 30158 0 0 75396 0 /kinetics/dendgeom yellow darkgreen \ 154.18 -20.942 0 simundump kreac /kinetics/chain/kinetics[3]/PLA2/PLA2-cytosolic/diff 0 0.001 \ 0.001 "" white black 155.18 -17.942 0 simundump kreac /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca-act 0 1.3263e-05 0.1 \ "" white darkgreen 154.9 -23.104 0 simundump kpool /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom yellow darkgreen 157.28 -23.646 0 simundump kenz /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca*/kenz 0 0 0 0 0 75396 \ 1.7906e-05 21.6 5.4 0 0 "" red yellow "" 159.94 -23.667 0 simundump kreac /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca*/diff 0 0.001 0.001 \ "" white black 158.28 -20.646 0 simundump kreac /kinetics/chain/kinetics[3]/PLA2/PIP2-PLA2-act 0 1.5916e-08 \ 0.5 "" white darkgreen 154.95 -18.75 0 simundump kpool /kinetics/chain/kinetics[3]/PLA2/PIP2-PLA2* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 157.32 -18.292 0 simundump kenz /kinetics/chain/kinetics[3]/PLA2/PIP2-PLA2*/kenz 0 0 0 0 0 \ 75396 3.6607e-05 44.16 11.04 0 0 "" red cyan "" 159.97 -18.271 0 simundump kreac /kinetics/chain/kinetics[3]/PLA2/PIP2-PLA2*/diff 0 0.001 \ 0.001 "" white black 158.32 -15.292 0 simundump kreac /kinetics/chain/kinetics[3]/PLA2/PIP2-Ca-PLA2-act 0 \ 1.5916e-07 0.1 "" white darkgreen 155.9 -19.5 0 simundump kpool /kinetics/chain/kinetics[3]/PLA2/PIP2-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 157.67 -19.896 0 simundump kenz /kinetics/chain/kinetics[3]/PLA2/PIP2-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00011937 144 36 0 0 "" red cyan "" 160.03 -19.979 0 simundump kreac /kinetics/chain/kinetics[3]/PLA2/PIP2-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 158.67 -16.896 0 simundump kreac /kinetics/chain/kinetics[3]/PLA2/DAG-Ca-PLA2-act 0 3.979e-08 \ 4 "" white darkgreen 155.17 -21.834 0 simundump kpool /kinetics/chain/kinetics[3]/PLA2/DAG-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom pink darkgreen 157.86 -22.479 0 simundump kenz /kinetics/chain/kinetics[3]/PLA2/DAG-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00019895 240 60 0 0 "" red pink "" 160.05 -22.354 0 simundump kreac /kinetics/chain/kinetics[3]/PLA2/DAG-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 158.86 -19.479 0 simundump kpool /kinetics/chain/kinetics[3]/PLA2/APC 0 -1e-12 30 30 \ 2.2619e+06 2.2619e+06 0 0 75396 4 /kinetics/dendgeom yellow darkgreen \ 157.76 -21.963 0 simundump kreac /kinetics/chain/kinetics[3]/PLA2/Degrade-AA 1 0.4 0 "" white \ darkgreen 159.82 -17.288 0 simundump kpool /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange darkgreen 158.19 -24.687 0 simundump kenz /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca/kenz 0 0 0 0 0 75396 \ 0.0003979 480 120 0 0 "" red orange "" 159.92 -24.817 0 simundump kreac /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca/diff 0 0.001 0.001 \ "" white black 159.19 -21.687 0 simundump kpool /kinetics/chain/kinetics[3]/PLA2/PLA2* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange darkgreen 156.98 -26.851 0 simundump kreac /kinetics/chain/kinetics[3]/PLA2/PLA2*/diff 0 0.001 0.001 "" \ white black 157.98 -23.851 0 simundump kreac /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca-act 1 7.958e-05 0.1 \ "" white darkgreen 155.91 -24.752 0 simundump kreac /kinetics/chain/kinetics[3]/PLA2/dephosphorylate-PLA2* 1 0.17 \ 0 "" white darkgreen 152.31 -23.735 0 simundump kpool /kinetics/chain/kinetics[3]/temp-PIP2 1 -1e-12 2.5 2.5 \ 1.8849e+05 1.8849e+05 0 0 75396 4 /kinetics/dendgeom green black 150.2 \ -19.047 0 simundump group /kinetics/chain/kinetics[3]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 181 -1 0 simundump kpool /kinetics/chain/kinetics[3]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 172 -4 0 simundump kpool /kinetics/chain/kinetics[3]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 175 -4 0 simundump kpool /kinetics/chain/kinetics[3]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 172 -8 0 simundump kpool /kinetics/chain/kinetics[3]/MAPK/MAPK 0 -1e-12 3.5999 3.5999 \ 2.7142e+05 2.7142e+05 0 0 75396 0 /kinetics/dendgeom pink brown 172 -11 0 simundump kreac /kinetics/chain/kinetics[3]/MAPK/MAPK/diff 0 0.001 0.001 "" \ white black 173 -8 0 simundump kpool /kinetics/chain/kinetics[3]/MAPK/craf-1** 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink brown 178 -4 0 simundump kpool /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr 1 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange brown 175 -11 0 simundump kreac /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr/diff 0 0.001 0.001 \ "" white black 176 -8 0 simundump kpool /kinetics/chain/kinetics[3]/MAPK/MAPKK* 0 0 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom pink brown 179 -8 0 simundump kenz /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 174 -9 0 simundump kenz /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 179 -9 0 simundump kpool /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 175 -8 0 simundump kpool /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 171 -6 0 simundump kenz /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 0 \ 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 174 -6 0 simundump kenz /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 0 \ 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 177 -6 0 simundump kpool /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red brown 171 -7 0 simundump kenz /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 174 -7 0 simundump kenz /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 177 -7 0 simundump kreac /kinetics/chain/kinetics[3]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 169 -3 0 simundump group /kinetics/chain/kinetics[3]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 180.51 4.351 0 simundump kreac /kinetics/chain/kinetics[3]/Ras/dephosph-GEF 1 1 0 "" white \ blue 175.07 5.881 0 simundump kpool /kinetics/chain/kinetics[3]/Ras/inact-GEF 1 -1e-12 0.1 0.1 \ 7539.6 7539.6 0 0 75396 0 /kinetics/dendgeom hotpink blue 178.45 6.352 0 simundump kenz /kinetics/chain/kinetics[3]/Ras/inact-GEF/basal_GEF_activity 0 \ 0 0 0 0 75396 1.313e-07 0.08 0.02 0 0 "" red hotpink "" 177 5 0 simundump kreac /kinetics/chain/kinetics[3]/Ras/inact-GEF/diff 0 0.001 0.001 \ "" white black 179.45 9.352 0 simundump kpool /kinetics/chain/kinetics[3]/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 172.45 5.246 0 simundump kenz /kinetics/chain/kinetics[3]/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 \ 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 173.08 4.086 0 simundump kreac /kinetics/chain/kinetics[3]/Ras/GEF*/diff 0 0.001 0.001 "" \ white black 173.45 8.246 0 simundump kpool /kinetics/chain/kinetics[3]/Ras/GTP-Ras 1 0 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange blue 178.56 1.084 0 simundump kpool /kinetics/chain/kinetics[3]/Ras/GDP-Ras 1 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink blue 172.13 2.165 0 simundump kreac /kinetics/chain/kinetics[3]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 175.1 1.5 0 simundump kreac /kinetics/chain/kinetics[3]/Ras/dephosph-GAP 1 0.1 0 "" white \ blue 170.02 3.524 0 simundump kpool /kinetics/chain/kinetics[3]/Ras/GAP* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red blue 167.35 2.349 0 simundump kreac /kinetics/chain/kinetics[3]/Ras/GAP*/diff 0 0.001 0.001 "" \ white black 168.35 5.349 0 simundump kpool /kinetics/chain/kinetics[3]/Ras/GAP 1 -1e-12 0.01 0.01 753.96 \ 753.96 0 0 75396 0 /kinetics/dendgeom red blue 172.65 0.338 0 simundump kenz /kinetics/chain/kinetics[3]/Ras/GAP/GAP-inact-ras 1 0 0 0 0 \ 75396 0.00065634 40 10 0 0 "" red red "" 175.01 0.403 0 simundump kreac /kinetics/chain/kinetics[3]/Ras/GAP/diff 0 0.001 0.001 "" \ white black 173.65 3.338 0 simundump kreac /kinetics/chain/kinetics[3]/Ras/CaM-bind-GEF 1 0.0026526 1 "" \ white blue 168.49 9.679 0 simundump kpool /kinetics/chain/kinetics[3]/Ras/CaM-GEF 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 171.35 7.58 0 simundump kenz /kinetics/chain/kinetics[3]/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 \ 0 0 75396 1.3131e-05 0.4 0.1 0 0 "" red pink "" 171.02 6.657 0 simundump kreac /kinetics/chain/kinetics[3]/Ras/CaM-GEF/diff 0 0.001 0.001 "" \ white black 172.35 10.58 0 simundump kpool /kinetics/chain/kinetics[3]/Ca 1 -1e-12 0.095 0.095 7162.6 \ 7162.6 0 0 75396 4 /kinetics/dendgeom red black 151 -13 0 simundump kpool /kinetics/chain/kinetics[3]/DAG 1 -1e-12 12.2 12.2 9.1983e+05 \ 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 166.72 -19.562 0 simundump kpool /kinetics/chain/kinetics[3]/PKC-active 1 -1e-12 0.3 \ 2.1196e-16 1.5981e-11 22619 0 0 75396 2 /kinetics/dendgeom red black 166 -3 \ 0 simundump kenz /kinetics/chain/kinetics[3]/PKC-active/PKC-act-raf 1 0 0 0 0 \ 75396 3.979e-06 16 4 0 0 "" red yellow "" 172 -2 0 simundump kenz /kinetics/chain/kinetics[3]/PKC-active/PKC-inact-GAP 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 170 1 0 simundump kenz /kinetics/chain/kinetics[3]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 175 8 0 simundump kenz /kinetics/chain/kinetics[3]/PKC-active/phosph-AC2 1 0 0 0 0 \ 75396 0.00066667 16 4 0 0 "" red red "" 159.32 -23.269 0 simundump kpool /kinetics/chain/kinetics[3]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 179 -11 0 simundump kenz /kinetics/chain/kinetics[3]/MAPK*/MAPK* 0 0 0 0 0 75396 \ 2.5864e-05 40 10 0 0 "" red orange "" 154 -26 0 simundump kenz /kinetics/chain/kinetics[3]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange "" 176 -2 0 simundump kreac /kinetics/chain/kinetics[3]/MAPK*/diff 0 0.001 0.001 "" white \ black 180 -8 0 simundump kpool /kinetics/chain/kinetics[3]/IP3 1 -1e-12 0.73 0.73 55039 \ 55039 0 0 75396 4 /kinetics/dendgeom pink black 165.23 -16.656 0 simundump kpool /kinetics/chain/kinetics[3]/MKP-1 1 -1e-12 0.024 0.024 1809.5 \ 1809.5 0 0 75396 0 /kinetics/dendgeom hotpink black 171 -10 0 simundump kenz /kinetics/chain/kinetics[3]/MKP-1/MKP1-tyr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 172 -9 0 simundump kenz /kinetics/chain/kinetics[3]/MKP-1/MKP1-thr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 177 -9 0 simundump kreac /kinetics/chain/kinetics[3]/MKP-1/diff 0 0.001 0.001 "" white \ black 172 -7 0 simundump kpool /kinetics/chain/kinetics[3]/PPhosphatase2A 1 -1e-12 1 1 75396 \ 75396 0 0 75396 0 /kinetics/dendgeom hotpink yellow 175 -3 0 simundump kenz /kinetics/chain/kinetics[3]/PPhosphatase2A/craf-deph 1 0 0 0 0 \ 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 174 -2 0 simundump kenz /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 177 -5 0 simundump kenz /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph-ser 1 0 \ 0 0 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 174 -5 0 simundump kenz /kinetics/chain/kinetics[3]/PPhosphatase2A/craf**-deph 1 0 0 0 \ 0 0.12566 2.5414e-05 24 6 0 0 "" red hotpink "" 178 -2 0 simundump kreac /kinetics/chain/kinetics[3]/PPhosphatase2A/diff 0 0.001 0.001 \ "" white black 176 0 0 simundump group /kinetics/chain/kinetics[3]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 153 -9 0 simundump kpool /kinetics/chain/kinetics[3]/CaM/CaM 1 -1e-12 20 20 1.5079e+06 \ 1.5079e+06 0 0 75396 0 /kinetics/dendgeom pink blue 152.98 -1.28 0 simundump kreac /kinetics/chain/kinetics[3]/CaM/CaM/diff 0 0.001 0.001 "" \ white black 153.98 1.72 0 simundump kreac /kinetics/chain/kinetics[3]/CaM/CaM-TR2-bind-Ca 1 1.2666e-08 \ 72 "" white blue 155.16 -1.921 0 simundump kreac /kinetics/chain/kinetics[3]/CaM/CaM-TR2-Ca2-bind-Ca 1 \ 4.7748e-05 10 "" white blue 154.16 -3.7747 0 simundump kreac /kinetics/chain/kinetics[3]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 152.6 -6.7404 0 simundump kpool /kinetics/chain/kinetics[3]/CaM/CaM-Ca3 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 156.49 -5.603 0 simundump kreac /kinetics/chain/kinetics[3]/CaM/CaM-Ca3/diff 0 0.001 0.001 "" \ white black 157.49 -2.603 0 simundump kpool /kinetics/chain/kinetics[3]/CaM/CaM-TR2-Ca2 1 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 158 -2.7423 0 simundump kreac /kinetics/chain/kinetics[3]/CaM/CaM-TR2-Ca2/diff 0 0.001 \ 0.001 "" white black 159 0.2577 0 simundump kpool /kinetics/chain/kinetics[3]/CaM/CaM-Ca4 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom blue blue 158 -8 0 simundump kreac /kinetics/chain/kinetics[3]/CaM/CaM-Ca4/diff 0 0.001 0.001 "" \ white black 159 -5 0 simundump kreac /kinetics/chain/kinetics[3]/Ras-act-unphosph-raf 0 7.958e-05 \ 1 "" white black 170 -4 0 simundump kpool /kinetics/chain/kinetics[3]/Ca_input 0 -1e-12 0.08 0.08 \ 6031.7 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 144 -7 0 simundump kreac /kinetics/chain/kinetics[3]/Ca_diff 0 2 2 "" white black 145 \ -12 0 simundump group /kinetics/chain/kinetics[4] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 204 0 0 simundump group /kinetics/chain/kinetics[4]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 212.95 -3.7837 0 simundump kpool /kinetics/chain/kinetics[4]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 211.92 -10.489 0 simundump kreac /kinetics/chain/kinetics[4]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 212.92 -7.489 0 simundump kreac /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca 0 7.958e-06 0.5 \ "" white blue 211.92 -12.123 0 simundump kreac /kinetics/chain/kinetics[4]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 213.94 -11.306 0 simundump kreac /kinetics/chain/kinetics[4]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 212.2 -7.7467 0 simundump kreac /kinetics/chain/kinetics[4]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 213.38 -9.2638 0 simundump kreac /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca-AA 0 1.5916e-08 \ 0.1 "" white blue 215.21 -8.1843 0 simundump kreac /kinetics/chain/kinetics[4]/PKC/PKC-act-by-DAG-AA 0 2 0.2 "" \ white blue 217.25 -8.7678 0 simundump kpool /kinetics/chain/kinetics[4]/PKC/PKC-DAG-AA* 0 -1e-12 \ 4.9137e-18 4.9137e-18 3.7047e-13 3.7047e-13 0 0 75396 0 /kinetics/dendgeom \ cyan blue 216.6 -6.463 0 simundump kreac /kinetics/chain/kinetics[4]/PKC/PKC-DAG-AA*/diff 0 0.001 \ 0.001 "" white black 217.6 -3.463 0 simundump kpool /kinetics/chain/kinetics[4]/PKC/PKC-Ca-AA* 0 -1e-12 \ 1.7501e-16 1.7501e-16 1.3195e-11 1.3195e-11 0 0 75396 0 /kinetics/dendgeom \ orange blue 215.4 -5.7044 0 simundump kreac /kinetics/chain/kinetics[4]/PKC/PKC-Ca-AA*/diff 0 0.001 0.001 \ "" white black 216.4 -2.7044 0 simundump kpool /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb* 0 -1e-12 \ 1.3896e-17 1.3896e-17 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom \ pink blue 213.22 -5.471 0 simundump kreac /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb*/diff 0 0.001 \ 0.001 "" white black 214.22 -2.471 0 simundump kpool /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb* 0 -1e-12 \ 9.4351e-21 9.4351e-21 7.1137e-16 7.1137e-16 0 0 75396 0 /kinetics/dendgeom \ yellow blue 214.17 -6.4922 0 simundump kreac /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb*/diff 0 0.001 \ 0.001 "" white black 215.17 -3.4922 0 simundump kpool /kinetics/chain/kinetics[4]/PKC/PKC-basal* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom pink blue 211.25 -6.4338 0 simundump kreac /kinetics/chain/kinetics[4]/PKC/PKC-basal*/diff 0 0.001 0.001 \ "" white black 212.25 -3.4338 0 simundump kreac /kinetics/chain/kinetics[4]/PKC/PKC-basal-act 0 1 50 "" white \ blue 211.02 -8.9429 0 simundump kpool /kinetics/chain/kinetics[4]/PKC/PKC-AA* 0 -1e-12 1.8134e-17 \ 1.8134e-17 1.3672e-12 1.3672e-12 0 0 75396 0 /kinetics/dendgeom cyan blue \ 217.78 -5.1793 0 simundump kreac /kinetics/chain/kinetics[4]/PKC/PKC-AA*/diff 0 0.001 0.001 "" \ white black 218.78 -2.1793 0 simundump kreac /kinetics/chain/kinetics[4]/PKC/PKC-act-by-AA 0 1.5916e-09 \ 0.1 "" white blue 211.01 -13.865 0 simundump kpool /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG 0 -1e-12 \ 8.4632e-23 8.4632e-23 6.3809e-18 6.3809e-18 0 0 75396 0 /kinetics/dendgeom \ white blue 216.23 -10.197 0 simundump kreac /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG/diff 0 0.001 0.001 \ "" white black 217.23 -7.197 0 simundump kreac /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 212.99 -13.99 0 simundump kpool /kinetics/chain/kinetics[4]/PKC/PKC-DAG 0 -1e-12 1.161e-16 \ 1.161e-16 8.7535e-12 8.7535e-12 0 0 75396 0 /kinetics/dendgeom white blue \ 215 -13.086 0 simundump kreac /kinetics/chain/kinetics[4]/PKC/PKC-DAG/diff 0 0.001 0.001 "" \ white black 216 -10.086 0 simundump kreac /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG-AA 0 2.3874e-07 2 \ "" white blue 214.77 -14.953 0 simundump kpool /kinetics/chain/kinetics[4]/PKC/PKC-DAG-AA 0 -1e-12 \ 2.5188e-19 2.5188e-19 1.8991e-14 1.8991e-14 0 0 75396 0 /kinetics/dendgeom \ white blue 216.62 -11.773 0 simundump kreac /kinetics/chain/kinetics[4]/PKC/PKC-DAG-AA/diff 0 0.001 0.001 \ "" white black 217.62 -8.773 0 simundump kpool /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic 0 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom white blue 209.87 -11.403 0 simundump kreac /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic/diff 0 0.001 \ 0.001 "" white black 210.87 -8.403 0 simundump kpool /kinetics/chain/kinetics[4]/AA 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom darkgreen black 212.71 -21.338 0 simundump kreac /kinetics/chain/kinetics[4]/AA/diff 0 0.001 0.001 "" white \ black 213.71 -18.338 0 simundump group /kinetics/chain/kinetics[4]/PLA2 0 darkgreen black x 0 1 "" \ defaultfile defaultfile.g 0 0 0 208.64 -26.209 0 simundump kpool /kinetics/chain/kinetics[4]/PLA2/PLA2-cytosolic 0 -1e-12 \ 0.39999 0.39999 30158 30158 0 0 75396 0 /kinetics/dendgeom yellow darkgreen \ 204.18 -20.942 0 simundump kreac /kinetics/chain/kinetics[4]/PLA2/PLA2-cytosolic/diff 0 0.001 \ 0.001 "" white black 205.18 -17.942 0 simundump kreac /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca-act 0 1.3263e-05 0.1 \ "" white darkgreen 204.9 -23.104 0 simundump kpool /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom yellow darkgreen 207.28 -23.646 0 simundump kenz /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca*/kenz 0 0 0 0 0 75396 \ 1.7906e-05 21.6 5.4 0 0 "" red yellow "" 209.94 -23.667 0 simundump kreac /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca*/diff 0 0.001 0.001 \ "" white black 208.28 -20.646 0 simundump kreac /kinetics/chain/kinetics[4]/PLA2/PIP2-PLA2-act 0 1.5916e-08 \ 0.5 "" white darkgreen 204.95 -18.75 0 simundump kpool /kinetics/chain/kinetics[4]/PLA2/PIP2-PLA2* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 207.32 -18.292 0 simundump kenz /kinetics/chain/kinetics[4]/PLA2/PIP2-PLA2*/kenz 0 0 0 0 0 \ 75396 3.6607e-05 44.16 11.04 0 0 "" red cyan "" 209.97 -18.271 0 simundump kreac /kinetics/chain/kinetics[4]/PLA2/PIP2-PLA2*/diff 0 0.001 \ 0.001 "" white black 208.32 -15.292 0 simundump kreac /kinetics/chain/kinetics[4]/PLA2/PIP2-Ca-PLA2-act 0 \ 1.5916e-07 0.1 "" white darkgreen 205.9 -19.5 0 simundump kpool /kinetics/chain/kinetics[4]/PLA2/PIP2-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 207.67 -19.896 0 simundump kenz /kinetics/chain/kinetics[4]/PLA2/PIP2-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00011937 144 36 0 0 "" red cyan "" 210.03 -19.979 0 simundump kreac /kinetics/chain/kinetics[4]/PLA2/PIP2-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 208.67 -16.896 0 simundump kreac /kinetics/chain/kinetics[4]/PLA2/DAG-Ca-PLA2-act 0 3.979e-08 \ 4 "" white darkgreen 205.17 -21.834 0 simundump kpool /kinetics/chain/kinetics[4]/PLA2/DAG-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom pink darkgreen 207.86 -22.479 0 simundump kenz /kinetics/chain/kinetics[4]/PLA2/DAG-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00019895 240 60 0 0 "" red pink "" 210.05 -22.354 0 simundump kreac /kinetics/chain/kinetics[4]/PLA2/DAG-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 208.86 -19.479 0 simundump kpool /kinetics/chain/kinetics[4]/PLA2/APC 0 -1e-12 30 30 \ 2.2619e+06 2.2619e+06 0 0 75396 4 /kinetics/dendgeom yellow darkgreen \ 207.76 -21.963 0 simundump kreac /kinetics/chain/kinetics[4]/PLA2/Degrade-AA 1 0.4 0 "" white \ darkgreen 209.82 -17.288 0 simundump kpool /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange darkgreen 208.19 -24.687 0 simundump kenz /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca/kenz 0 0 0 0 0 75396 \ 0.0003979 480 120 0 0 "" red orange "" 209.92 -24.817 0 simundump kreac /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca/diff 0 0.001 0.001 \ "" white black 209.19 -21.687 0 simundump kpool /kinetics/chain/kinetics[4]/PLA2/PLA2* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange darkgreen 206.98 -26.851 0 simundump kreac /kinetics/chain/kinetics[4]/PLA2/PLA2*/diff 0 0.001 0.001 "" \ white black 207.98 -23.851 0 simundump kreac /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca-act 1 7.958e-05 0.1 \ "" white darkgreen 205.91 -24.752 0 simundump kreac /kinetics/chain/kinetics[4]/PLA2/dephosphorylate-PLA2* 1 0.17 \ 0 "" white darkgreen 202.31 -23.735 0 simundump kpool /kinetics/chain/kinetics[4]/temp-PIP2 1 -1e-12 2.5 2.5 \ 1.8849e+05 1.8849e+05 0 0 75396 4 /kinetics/dendgeom green black 200.2 \ -19.047 0 simundump group /kinetics/chain/kinetics[4]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 231 -1 0 simundump kpool /kinetics/chain/kinetics[4]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 222 -4 0 simundump kpool /kinetics/chain/kinetics[4]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 225 -4 0 simundump kpool /kinetics/chain/kinetics[4]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 222 -8 0 simundump kpool /kinetics/chain/kinetics[4]/MAPK/MAPK 0 -1e-12 3.5999 3.5999 \ 2.7142e+05 2.7142e+05 0 0 75396 0 /kinetics/dendgeom pink brown 222 -11 0 simundump kreac /kinetics/chain/kinetics[4]/MAPK/MAPK/diff 0 0.001 0.001 "" \ white black 223 -8 0 simundump kpool /kinetics/chain/kinetics[4]/MAPK/craf-1** 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink brown 228 -4 0 simundump kpool /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr 1 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange brown 225 -11 0 simundump kreac /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr/diff 0 0.001 0.001 \ "" white black 226 -8 0 simundump kpool /kinetics/chain/kinetics[4]/MAPK/MAPKK* 0 0 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom pink brown 229 -8 0 simundump kenz /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 224 -9 0 simundump kenz /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 229 -9 0 simundump kpool /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 225 -8 0 simundump kpool /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 221 -6 0 simundump kenz /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 0 \ 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 224 -6 0 simundump kenz /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 0 \ 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 227 -6 0 simundump kpool /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red brown 221 -7 0 simundump kenz /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 224 -7 0 simundump kenz /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 227 -7 0 simundump kreac /kinetics/chain/kinetics[4]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 219 -3 0 simundump group /kinetics/chain/kinetics[4]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 230.51 4.351 0 simundump kreac /kinetics/chain/kinetics[4]/Ras/dephosph-GEF 1 1 0 "" white \ blue 225.07 5.881 0 simundump kpool /kinetics/chain/kinetics[4]/Ras/inact-GEF 1 -1e-12 0.1 0.1 \ 7539.6 7539.6 0 0 75396 0 /kinetics/dendgeom hotpink blue 228.45 6.352 0 simundump kenz /kinetics/chain/kinetics[4]/Ras/inact-GEF/basal_GEF_activity 0 \ 0 0 0 0 75396 1.313e-07 0.08 0.02 0 0 "" red hotpink "" 227 5 0 simundump kreac /kinetics/chain/kinetics[4]/Ras/inact-GEF/diff 0 0.001 0.001 \ "" white black 229.45 9.352 0 simundump kpool /kinetics/chain/kinetics[4]/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 222.45 5.246 0 simundump kenz /kinetics/chain/kinetics[4]/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 \ 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 223.08 4.086 0 simundump kreac /kinetics/chain/kinetics[4]/Ras/GEF*/diff 0 0.001 0.001 "" \ white black 223.45 8.246 0 simundump kpool /kinetics/chain/kinetics[4]/Ras/GTP-Ras 1 0 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange blue 228.56 1.084 0 simundump kpool /kinetics/chain/kinetics[4]/Ras/GDP-Ras 1 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink blue 222.13 2.165 0 simundump kreac /kinetics/chain/kinetics[4]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 225.1 1.5 0 simundump kreac /kinetics/chain/kinetics[4]/Ras/dephosph-GAP 1 0.1 0 "" white \ blue 220.02 3.524 0 simundump kpool /kinetics/chain/kinetics[4]/Ras/GAP* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red blue 217.35 2.349 0 simundump kreac /kinetics/chain/kinetics[4]/Ras/GAP*/diff 0 0.001 0.001 "" \ white black 218.35 5.349 0 simundump kpool /kinetics/chain/kinetics[4]/Ras/GAP 1 -1e-12 0.01 0.01 753.96 \ 753.96 0 0 75396 0 /kinetics/dendgeom red blue 222.65 0.338 0 simundump kenz /kinetics/chain/kinetics[4]/Ras/GAP/GAP-inact-ras 1 0 0 0 0 \ 75396 0.00065634 40 10 0 0 "" red red "" 225.01 0.403 0 simundump kreac /kinetics/chain/kinetics[4]/Ras/GAP/diff 0 0.001 0.001 "" \ white black 223.65 3.338 0 simundump kreac /kinetics/chain/kinetics[4]/Ras/CaM-bind-GEF 1 0.0026526 1 "" \ white blue 218.49 9.679 0 simundump kpool /kinetics/chain/kinetics[4]/Ras/CaM-GEF 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 221.35 7.58 0 simundump kenz /kinetics/chain/kinetics[4]/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 \ 0 0 75396 1.3131e-05 0.4 0.1 0 0 "" red pink "" 221.02 6.657 0 simundump kreac /kinetics/chain/kinetics[4]/Ras/CaM-GEF/diff 0 0.001 0.001 "" \ white black 222.35 10.58 0 simundump kpool /kinetics/chain/kinetics[4]/Ca 1 -1e-12 0.095 0.095 7162.6 \ 7162.6 0 0 75396 4 /kinetics/dendgeom red black 201 -13 0 simundump kpool /kinetics/chain/kinetics[4]/DAG 1 -1e-12 12.2 12.2 9.1983e+05 \ 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 216.72 -19.562 0 simundump kpool /kinetics/chain/kinetics[4]/PKC-active 1 -1e-12 0.3 \ 2.1196e-16 1.5981e-11 22619 0 0 75396 2 /kinetics/dendgeom red black 216 -3 \ 0 simundump kenz /kinetics/chain/kinetics[4]/PKC-active/PKC-act-raf 1 0 0 0 0 \ 75396 3.979e-06 16 4 0 0 "" red yellow "" 222 -2 0 simundump kenz /kinetics/chain/kinetics[4]/PKC-active/PKC-inact-GAP 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 220 1 0 simundump kenz /kinetics/chain/kinetics[4]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 225 8 0 simundump kenz /kinetics/chain/kinetics[4]/PKC-active/phosph-AC2 1 0 0 0 0 \ 75396 0.00066667 16 4 0 0 "" red red "" 209.32 -23.269 0 simundump kpool /kinetics/chain/kinetics[4]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 229 -11 0 simundump kenz /kinetics/chain/kinetics[4]/MAPK*/MAPK* 0 0 0 0 0 75396 \ 2.5864e-05 40 10 0 0 "" red orange "" 204 -26 0 simundump kenz /kinetics/chain/kinetics[4]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange "" 226 -2 0 simundump kreac /kinetics/chain/kinetics[4]/MAPK*/diff 0 0.001 0.001 "" white \ black 230 -8 0 simundump kpool /kinetics/chain/kinetics[4]/IP3 1 -1e-12 0.73 0.73 55039 \ 55039 0 0 75396 4 /kinetics/dendgeom pink black 215.23 -16.656 0 simundump kpool /kinetics/chain/kinetics[4]/MKP-1 1 -1e-12 0.024 0.024 1809.5 \ 1809.5 0 0 75396 0 /kinetics/dendgeom hotpink black 221 -10 0 simundump kenz /kinetics/chain/kinetics[4]/MKP-1/MKP1-tyr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 222 -9 0 simundump kenz /kinetics/chain/kinetics[4]/MKP-1/MKP1-thr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 227 -9 0 simundump kreac /kinetics/chain/kinetics[4]/MKP-1/diff 0 0.001 0.001 "" white \ black 222 -7 0 simundump kpool /kinetics/chain/kinetics[4]/PPhosphatase2A 1 -1e-12 1 1 75396 \ 75396 0 0 75396 0 /kinetics/dendgeom hotpink yellow 225 -3 0 simundump kenz /kinetics/chain/kinetics[4]/PPhosphatase2A/craf-deph 1 0 0 0 0 \ 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 224 -2 0 simundump kenz /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 227 -5 0 simundump kenz /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph-ser 1 0 \ 0 0 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 224 -5 0 simundump kenz /kinetics/chain/kinetics[4]/PPhosphatase2A/craf**-deph 1 0 0 0 \ 0 0.12566 2.5414e-05 24 6 0 0 "" red hotpink "" 228 -2 0 simundump kreac /kinetics/chain/kinetics[4]/PPhosphatase2A/diff 0 0.001 0.001 \ "" white black 226 0 0 simundump group /kinetics/chain/kinetics[4]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 203 -9 0 simundump kpool /kinetics/chain/kinetics[4]/CaM/CaM 1 -1e-12 20 20 1.5079e+06 \ 1.5079e+06 0 0 75396 0 /kinetics/dendgeom pink blue 202.98 -1.28 0 simundump kreac /kinetics/chain/kinetics[4]/CaM/CaM/diff 0 0.001 0.001 "" \ white black 203.98 1.72 0 simundump kreac /kinetics/chain/kinetics[4]/CaM/CaM-TR2-bind-Ca 1 1.2666e-08 \ 72 "" white blue 205.16 -1.921 0 simundump kreac /kinetics/chain/kinetics[4]/CaM/CaM-TR2-Ca2-bind-Ca 1 \ 4.7748e-05 10 "" white blue 204.16 -3.7747 0 simundump kreac /kinetics/chain/kinetics[4]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 202.6 -6.7404 0 simundump kpool /kinetics/chain/kinetics[4]/CaM/CaM-Ca3 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 206.49 -5.603 0 simundump kreac /kinetics/chain/kinetics[4]/CaM/CaM-Ca3/diff 0 0.001 0.001 "" \ white black 207.49 -2.603 0 simundump kpool /kinetics/chain/kinetics[4]/CaM/CaM-TR2-Ca2 1 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 208 -2.7423 0 simundump kreac /kinetics/chain/kinetics[4]/CaM/CaM-TR2-Ca2/diff 0 0.001 \ 0.001 "" white black 209 0.2577 0 simundump kpool /kinetics/chain/kinetics[4]/CaM/CaM-Ca4 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom blue blue 208 -8 0 simundump kreac /kinetics/chain/kinetics[4]/CaM/CaM-Ca4/diff 0 0.001 0.001 "" \ white black 209 -5 0 simundump kreac /kinetics/chain/kinetics[4]/Ras-act-unphosph-raf 0 7.958e-05 \ 1 "" white black 220 -4 0 simundump kpool /kinetics/chain/kinetics[4]/Ca_input 0 -1e-12 0.08 0.08 \ 6031.7 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 194 -7 0 simundump kreac /kinetics/chain/kinetics[4]/Ca_diff 0 2 2 "" white black 195 \ -12 0 simundump group /kinetics/chain/kinetics[5] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 254 0 0 simundump group /kinetics/chain/kinetics[5]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 262.95 -3.7837 0 simundump kpool /kinetics/chain/kinetics[5]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 261.92 -10.489 0 simundump kreac /kinetics/chain/kinetics[5]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 262.92 -7.489 0 simundump kreac /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca 0 7.958e-06 0.5 \ "" white blue 261.92 -12.123 0 simundump kreac /kinetics/chain/kinetics[5]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 263.94 -11.306 0 simundump kreac /kinetics/chain/kinetics[5]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 262.2 -7.7467 0 simundump kreac /kinetics/chain/kinetics[5]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 263.38 -9.2638 0 simundump kreac /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca-AA 0 1.5916e-08 \ 0.1 "" white blue 265.21 -8.1843 0 simundump kreac /kinetics/chain/kinetics[5]/PKC/PKC-act-by-DAG-AA 0 2 0.2 "" \ white blue 267.25 -8.7678 0 simundump kpool /kinetics/chain/kinetics[5]/PKC/PKC-DAG-AA* 0 -1e-12 \ 4.9137e-18 4.9137e-18 3.7047e-13 3.7047e-13 0 0 75396 0 /kinetics/dendgeom \ cyan blue 266.6 -6.463 0 simundump kreac /kinetics/chain/kinetics[5]/PKC/PKC-DAG-AA*/diff 0 0.001 \ 0.001 "" white black 267.6 -3.463 0 simundump kpool /kinetics/chain/kinetics[5]/PKC/PKC-Ca-AA* 0 -1e-12 \ 1.7501e-16 1.7501e-16 1.3195e-11 1.3195e-11 0 0 75396 0 /kinetics/dendgeom \ orange blue 265.4 -5.7044 0 simundump kreac /kinetics/chain/kinetics[5]/PKC/PKC-Ca-AA*/diff 0 0.001 0.001 \ "" white black 266.4 -2.7044 0 simundump kpool /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb* 0 -1e-12 \ 1.3896e-17 1.3896e-17 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom \ pink blue 263.22 -5.471 0 simundump kreac /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb*/diff 0 0.001 \ 0.001 "" white black 264.22 -2.471 0 simundump kpool /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb* 0 -1e-12 \ 9.4351e-21 9.4351e-21 7.1137e-16 7.1137e-16 0 0 75396 0 /kinetics/dendgeom \ yellow blue 264.17 -6.4922 0 simundump kreac /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb*/diff 0 0.001 \ 0.001 "" white black 265.17 -3.4922 0 simundump kpool /kinetics/chain/kinetics[5]/PKC/PKC-basal* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom pink blue 261.25 -6.4338 0 simundump kreac /kinetics/chain/kinetics[5]/PKC/PKC-basal*/diff 0 0.001 0.001 \ "" white black 262.25 -3.4338 0 simundump kreac /kinetics/chain/kinetics[5]/PKC/PKC-basal-act 0 1 50 "" white \ blue 261.02 -8.9429 0 simundump kpool /kinetics/chain/kinetics[5]/PKC/PKC-AA* 0 -1e-12 1.8134e-17 \ 1.8134e-17 1.3672e-12 1.3672e-12 0 0 75396 0 /kinetics/dendgeom cyan blue \ 267.78 -5.1793 0 simundump kreac /kinetics/chain/kinetics[5]/PKC/PKC-AA*/diff 0 0.001 0.001 "" \ white black 268.78 -2.1793 0 simundump kreac /kinetics/chain/kinetics[5]/PKC/PKC-act-by-AA 0 1.5916e-09 \ 0.1 "" white blue 261.01 -13.865 0 simundump kpool /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG 0 -1e-12 \ 8.4632e-23 8.4632e-23 6.3809e-18 6.3809e-18 0 0 75396 0 /kinetics/dendgeom \ white blue 266.23 -10.197 0 simundump kreac /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG/diff 0 0.001 0.001 \ "" white black 267.23 -7.197 0 simundump kreac /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 262.99 -13.99 0 simundump kpool /kinetics/chain/kinetics[5]/PKC/PKC-DAG 0 -1e-12 1.161e-16 \ 1.161e-16 8.7535e-12 8.7535e-12 0 0 75396 0 /kinetics/dendgeom white blue \ 265 -13.086 0 simundump kreac /kinetics/chain/kinetics[5]/PKC/PKC-DAG/diff 0 0.001 0.001 "" \ white black 266 -10.086 0 simundump kreac /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG-AA 0 2.3874e-07 2 \ "" white blue 264.77 -14.953 0 simundump kpool /kinetics/chain/kinetics[5]/PKC/PKC-DAG-AA 0 -1e-12 \ 2.5188e-19 2.5188e-19 1.8991e-14 1.8991e-14 0 0 75396 0 /kinetics/dendgeom \ white blue 266.62 -11.773 0 simundump kreac /kinetics/chain/kinetics[5]/PKC/PKC-DAG-AA/diff 0 0.001 0.001 \ "" white black 267.62 -8.773 0 simundump kpool /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic 0 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom white blue 259.87 -11.403 0 simundump kreac /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic/diff 0 0.001 \ 0.001 "" white black 260.87 -8.403 0 simundump kpool /kinetics/chain/kinetics[5]/AA 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom darkgreen black 262.71 -21.338 0 simundump kreac /kinetics/chain/kinetics[5]/AA/diff 0 0.001 0.001 "" white \ black 263.71 -18.338 0 simundump group /kinetics/chain/kinetics[5]/PLA2 0 darkgreen black x 0 1 "" \ defaultfile defaultfile.g 0 0 0 258.64 -26.209 0 simundump kpool /kinetics/chain/kinetics[5]/PLA2/PLA2-cytosolic 0 -1e-12 \ 0.39999 0.39999 30158 30158 0 0 75396 0 /kinetics/dendgeom yellow darkgreen \ 254.18 -20.942 0 simundump kreac /kinetics/chain/kinetics[5]/PLA2/PLA2-cytosolic/diff 0 0.001 \ 0.001 "" white black 255.18 -17.942 0 simundump kreac /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca-act 0 1.3263e-05 0.1 \ "" white darkgreen 254.9 -23.104 0 simundump kpool /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom yellow darkgreen 257.28 -23.646 0 simundump kenz /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca*/kenz 0 0 0 0 0 75396 \ 1.7906e-05 21.6 5.4 0 0 "" red yellow "" 259.94 -23.667 0 simundump kreac /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca*/diff 0 0.001 0.001 \ "" white black 258.28 -20.646 0 simundump kreac /kinetics/chain/kinetics[5]/PLA2/PIP2-PLA2-act 0 1.5916e-08 \ 0.5 "" white darkgreen 254.95 -18.75 0 simundump kpool /kinetics/chain/kinetics[5]/PLA2/PIP2-PLA2* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 257.32 -18.292 0 simundump kenz /kinetics/chain/kinetics[5]/PLA2/PIP2-PLA2*/kenz 0 0 0 0 0 \ 75396 3.6607e-05 44.16 11.04 0 0 "" red cyan "" 259.97 -18.271 0 simundump kreac /kinetics/chain/kinetics[5]/PLA2/PIP2-PLA2*/diff 0 0.001 \ 0.001 "" white black 258.32 -15.292 0 simundump kreac /kinetics/chain/kinetics[5]/PLA2/PIP2-Ca-PLA2-act 0 \ 1.5916e-07 0.1 "" white darkgreen 255.9 -19.5 0 simundump kpool /kinetics/chain/kinetics[5]/PLA2/PIP2-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 257.67 -19.896 0 simundump kenz /kinetics/chain/kinetics[5]/PLA2/PIP2-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00011937 144 36 0 0 "" red cyan "" 260.03 -19.979 0 simundump kreac /kinetics/chain/kinetics[5]/PLA2/PIP2-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 258.67 -16.896 0 simundump kreac /kinetics/chain/kinetics[5]/PLA2/DAG-Ca-PLA2-act 0 3.979e-08 \ 4 "" white darkgreen 255.17 -21.834 0 simundump kpool /kinetics/chain/kinetics[5]/PLA2/DAG-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom pink darkgreen 257.86 -22.479 0 simundump kenz /kinetics/chain/kinetics[5]/PLA2/DAG-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00019895 240 60 0 0 "" red pink "" 260.05 -22.354 0 simundump kreac /kinetics/chain/kinetics[5]/PLA2/DAG-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 258.86 -19.479 0 simundump kpool /kinetics/chain/kinetics[5]/PLA2/APC 0 -1e-12 30 30 \ 2.2619e+06 2.2619e+06 0 0 75396 4 /kinetics/dendgeom yellow darkgreen \ 257.76 -21.963 0 simundump kreac /kinetics/chain/kinetics[5]/PLA2/Degrade-AA 1 0.4 0 "" white \ darkgreen 259.82 -17.288 0 simundump kpool /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange darkgreen 258.19 -24.687 0 simundump kenz /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca/kenz 0 0 0 0 0 75396 \ 0.0003979 480 120 0 0 "" red orange "" 259.92 -24.817 0 simundump kreac /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca/diff 0 0.001 0.001 \ "" white black 259.19 -21.687 0 simundump kpool /kinetics/chain/kinetics[5]/PLA2/PLA2* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange darkgreen 256.98 -26.851 0 simundump kreac /kinetics/chain/kinetics[5]/PLA2/PLA2*/diff 0 0.001 0.001 "" \ white black 257.98 -23.851 0 simundump kreac /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca-act 1 7.958e-05 0.1 \ "" white darkgreen 255.91 -24.752 0 simundump kreac /kinetics/chain/kinetics[5]/PLA2/dephosphorylate-PLA2* 1 0.17 \ 0 "" white darkgreen 252.31 -23.735 0 simundump kpool /kinetics/chain/kinetics[5]/temp-PIP2 1 -1e-12 2.5 2.5 \ 1.8849e+05 1.8849e+05 0 0 75396 4 /kinetics/dendgeom green black 250.2 \ -19.047 0 simundump group /kinetics/chain/kinetics[5]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 281 -1 0 simundump kpool /kinetics/chain/kinetics[5]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 272 -4 0 simundump kpool /kinetics/chain/kinetics[5]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 275 -4 0 simundump kpool /kinetics/chain/kinetics[5]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 272 -8 0 simundump kpool /kinetics/chain/kinetics[5]/MAPK/MAPK 0 -1e-12 3.5999 3.5999 \ 2.7142e+05 2.7142e+05 0 0 75396 0 /kinetics/dendgeom pink brown 272 -11 0 simundump kreac /kinetics/chain/kinetics[5]/MAPK/MAPK/diff 0 0.001 0.001 "" \ white black 273 -8 0 simundump kpool /kinetics/chain/kinetics[5]/MAPK/craf-1** 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink brown 278 -4 0 simundump kpool /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr 1 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange brown 275 -11 0 simundump kreac /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr/diff 0 0.001 0.001 \ "" white black 276 -8 0 simundump kpool /kinetics/chain/kinetics[5]/MAPK/MAPKK* 0 0 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom pink brown 279 -8 0 simundump kenz /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 274 -9 0 simundump kenz /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 279 -9 0 simundump kpool /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 275 -8 0 simundump kpool /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 271 -6 0 simundump kenz /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 0 \ 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 274 -6 0 simundump kenz /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 0 \ 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 277 -6 0 simundump kpool /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red brown 271 -7 0 simundump kenz /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 274 -7 0 simundump kenz /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 277 -7 0 simundump kreac /kinetics/chain/kinetics[5]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 269 -3 0 simundump group /kinetics/chain/kinetics[5]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 280.51 4.351 0 simundump kreac /kinetics/chain/kinetics[5]/Ras/dephosph-GEF 1 1 0 "" white \ blue 275.07 5.881 0 simundump kpool /kinetics/chain/kinetics[5]/Ras/inact-GEF 1 -1e-12 0.1 0.1 \ 7539.6 7539.6 0 0 75396 0 /kinetics/dendgeom hotpink blue 278.45 6.352 0 simundump kenz /kinetics/chain/kinetics[5]/Ras/inact-GEF/basal_GEF_activity 0 \ 0 0 0 0 75396 1.313e-07 0.08 0.02 0 0 "" red hotpink "" 277 5 0 simundump kreac /kinetics/chain/kinetics[5]/Ras/inact-GEF/diff 0 0.001 0.001 \ "" white black 279.45 9.352 0 simundump kpool /kinetics/chain/kinetics[5]/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 272.45 5.246 0 simundump kenz /kinetics/chain/kinetics[5]/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 \ 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 273.08 4.086 0 simundump kreac /kinetics/chain/kinetics[5]/Ras/GEF*/diff 0 0.001 0.001 "" \ white black 273.45 8.246 0 simundump kpool /kinetics/chain/kinetics[5]/Ras/GTP-Ras 1 0 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange blue 278.56 1.084 0 simundump kpool /kinetics/chain/kinetics[5]/Ras/GDP-Ras 1 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink blue 272.13 2.165 0 simundump kreac /kinetics/chain/kinetics[5]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 275.1 1.5 0 simundump kreac /kinetics/chain/kinetics[5]/Ras/dephosph-GAP 1 0.1 0 "" white \ blue 270.02 3.524 0 simundump kpool /kinetics/chain/kinetics[5]/Ras/GAP* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red blue 267.35 2.349 0 simundump kreac /kinetics/chain/kinetics[5]/Ras/GAP*/diff 0 0.001 0.001 "" \ white black 268.35 5.349 0 simundump kpool /kinetics/chain/kinetics[5]/Ras/GAP 1 -1e-12 0.01 0.01 753.96 \ 753.96 0 0 75396 0 /kinetics/dendgeom red blue 272.65 0.338 0 simundump kenz /kinetics/chain/kinetics[5]/Ras/GAP/GAP-inact-ras 1 0 0 0 0 \ 75396 0.00065634 40 10 0 0 "" red red "" 275.01 0.403 0 simundump kreac /kinetics/chain/kinetics[5]/Ras/GAP/diff 0 0.001 0.001 "" \ white black 273.65 3.338 0 simundump kreac /kinetics/chain/kinetics[5]/Ras/CaM-bind-GEF 1 0.0026526 1 "" \ white blue 268.49 9.679 0 simundump kpool /kinetics/chain/kinetics[5]/Ras/CaM-GEF 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 271.35 7.58 0 simundump kenz /kinetics/chain/kinetics[5]/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 \ 0 0 75396 1.3131e-05 0.4 0.1 0 0 "" red pink "" 271.02 6.657 0 simundump kreac /kinetics/chain/kinetics[5]/Ras/CaM-GEF/diff 0 0.001 0.001 "" \ white black 272.35 10.58 0 simundump kpool /kinetics/chain/kinetics[5]/Ca 1 -1e-12 0.095 0.095 7162.6 \ 7162.6 0 0 75396 4 /kinetics/dendgeom red black 251 -13 0 simundump kpool /kinetics/chain/kinetics[5]/DAG 1 -1e-12 12.2 12.2 9.1983e+05 \ 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 266.72 -19.562 0 simundump kpool /kinetics/chain/kinetics[5]/PKC-active 1 -1e-12 0.3 \ 2.1196e-16 1.5981e-11 22619 0 0 75396 2 /kinetics/dendgeom red black 266 -3 \ 0 simundump kenz /kinetics/chain/kinetics[5]/PKC-active/PKC-act-raf 1 0 0 0 0 \ 75396 3.979e-06 16 4 0 0 "" red yellow "" 272 -2 0 simundump kenz /kinetics/chain/kinetics[5]/PKC-active/PKC-inact-GAP 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 270 1 0 simundump kenz /kinetics/chain/kinetics[5]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 275 8 0 simundump kenz /kinetics/chain/kinetics[5]/PKC-active/phosph-AC2 1 0 0 0 0 \ 75396 0.00066667 16 4 0 0 "" red red "" 259.32 -23.269 0 simundump kpool /kinetics/chain/kinetics[5]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 279 -11 0 simundump kenz /kinetics/chain/kinetics[5]/MAPK*/MAPK* 0 0 0 0 0 75396 \ 2.5864e-05 40 10 0 0 "" red orange "" 254 -26 0 simundump kenz /kinetics/chain/kinetics[5]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange "" 276 -2 0 simundump kreac /kinetics/chain/kinetics[5]/MAPK*/diff 0 0.001 0.001 "" white \ black 280 -8 0 simundump kpool /kinetics/chain/kinetics[5]/IP3 1 -1e-12 0.73 0.73 55039 \ 55039 0 0 75396 4 /kinetics/dendgeom pink black 265.23 -16.656 0 simundump kpool /kinetics/chain/kinetics[5]/MKP-1 1 -1e-12 0.024 0.024 1809.5 \ 1809.5 0 0 75396 0 /kinetics/dendgeom hotpink black 271 -10 0 simundump kenz /kinetics/chain/kinetics[5]/MKP-1/MKP1-tyr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 272 -9 0 simundump kenz /kinetics/chain/kinetics[5]/MKP-1/MKP1-thr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 277 -9 0 simundump kreac /kinetics/chain/kinetics[5]/MKP-1/diff 0 0.001 0.001 "" white \ black 272 -7 0 simundump kpool /kinetics/chain/kinetics[5]/PPhosphatase2A 1 -1e-12 1 1 75396 \ 75396 0 0 75396 0 /kinetics/dendgeom hotpink yellow 275 -3 0 simundump kenz /kinetics/chain/kinetics[5]/PPhosphatase2A/craf-deph 1 0 0 0 0 \ 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 274 -2 0 simundump kenz /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 277 -5 0 simundump kenz /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph-ser 1 0 \ 0 0 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 274 -5 0 simundump kenz /kinetics/chain/kinetics[5]/PPhosphatase2A/craf**-deph 1 0 0 0 \ 0 0.12566 2.5414e-05 24 6 0 0 "" red hotpink "" 278 -2 0 simundump kreac /kinetics/chain/kinetics[5]/PPhosphatase2A/diff 0 0.001 0.001 \ "" white black 276 0 0 simundump group /kinetics/chain/kinetics[5]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 253 -9 0 simundump kpool /kinetics/chain/kinetics[5]/CaM/CaM 1 -1e-12 20 20 1.5079e+06 \ 1.5079e+06 0 0 75396 0 /kinetics/dendgeom pink blue 252.98 -1.28 0 simundump kreac /kinetics/chain/kinetics[5]/CaM/CaM/diff 0 0.001 0.001 "" \ white black 253.98 1.72 0 simundump kreac /kinetics/chain/kinetics[5]/CaM/CaM-TR2-bind-Ca 1 1.2666e-08 \ 72 "" white blue 255.16 -1.921 0 simundump kreac /kinetics/chain/kinetics[5]/CaM/CaM-TR2-Ca2-bind-Ca 1 \ 4.7748e-05 10 "" white blue 254.16 -3.7747 0 simundump kreac /kinetics/chain/kinetics[5]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 252.6 -6.7404 0 simundump kpool /kinetics/chain/kinetics[5]/CaM/CaM-Ca3 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 256.49 -5.603 0 simundump kreac /kinetics/chain/kinetics[5]/CaM/CaM-Ca3/diff 0 0.001 0.001 "" \ white black 257.49 -2.603 0 simundump kpool /kinetics/chain/kinetics[5]/CaM/CaM-TR2-Ca2 1 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 258 -2.7423 0 simundump kreac /kinetics/chain/kinetics[5]/CaM/CaM-TR2-Ca2/diff 0 0.001 \ 0.001 "" white black 259 0.2577 0 simundump kpool /kinetics/chain/kinetics[5]/CaM/CaM-Ca4 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom blue blue 258 -8 0 simundump kreac /kinetics/chain/kinetics[5]/CaM/CaM-Ca4/diff 0 0.001 0.001 "" \ white black 259 -5 0 simundump kreac /kinetics/chain/kinetics[5]/Ras-act-unphosph-raf 0 7.958e-05 \ 1 "" white black 270 -4 0 simundump kpool /kinetics/chain/kinetics[5]/Ca_input 0 -1e-12 0.08 0.08 \ 6031.7 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 244 -7 0 simundump kreac /kinetics/chain/kinetics[5]/Ca_diff 0 2 2 "" white black 245 \ -12 0 simundump group /kinetics/chain/kinetics[6] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 304 0 0 simundump group /kinetics/chain/kinetics[6]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 312.95 -3.7837 0 simundump kpool /kinetics/chain/kinetics[6]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 311.92 -10.489 0 simundump kreac /kinetics/chain/kinetics[6]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 312.92 -7.489 0 simundump kreac /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca 0 7.958e-06 0.5 \ "" white blue 311.92 -12.123 0 simundump kreac /kinetics/chain/kinetics[6]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 313.94 -11.306 0 simundump kreac /kinetics/chain/kinetics[6]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 312.2 -7.7467 0 simundump kreac /kinetics/chain/kinetics[6]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 313.38 -9.2638 0 simundump kreac /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca-AA 0 1.5916e-08 \ 0.1 "" white blue 315.21 -8.1843 0 simundump kreac /kinetics/chain/kinetics[6]/PKC/PKC-act-by-DAG-AA 0 2 0.2 "" \ white blue 317.25 -8.7678 0 simundump kpool /kinetics/chain/kinetics[6]/PKC/PKC-DAG-AA* 0 -1e-12 \ 4.9137e-18 4.9137e-18 3.7047e-13 3.7047e-13 0 0 75396 0 /kinetics/dendgeom \ cyan blue 316.6 -6.463 0 simundump kreac /kinetics/chain/kinetics[6]/PKC/PKC-DAG-AA*/diff 0 0.001 \ 0.001 "" white black 317.6 -3.463 0 simundump kpool /kinetics/chain/kinetics[6]/PKC/PKC-Ca-AA* 0 -1e-12 \ 1.7501e-16 1.7501e-16 1.3195e-11 1.3195e-11 0 0 75396 0 /kinetics/dendgeom \ orange blue 315.4 -5.7044 0 simundump kreac /kinetics/chain/kinetics[6]/PKC/PKC-Ca-AA*/diff 0 0.001 0.001 \ "" white black 316.4 -2.7044 0 simundump kpool /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb* 0 -1e-12 \ 1.3896e-17 1.3896e-17 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom \ pink blue 313.22 -5.471 0 simundump kreac /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb*/diff 0 0.001 \ 0.001 "" white black 314.22 -2.471 0 simundump kpool /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb* 0 -1e-12 \ 9.4351e-21 9.4351e-21 7.1137e-16 7.1137e-16 0 0 75396 0 /kinetics/dendgeom \ yellow blue 314.17 -6.4922 0 simundump kreac /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb*/diff 0 0.001 \ 0.001 "" white black 315.17 -3.4922 0 simundump kpool /kinetics/chain/kinetics[6]/PKC/PKC-basal* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom pink blue 311.25 -6.4338 0 simundump kreac /kinetics/chain/kinetics[6]/PKC/PKC-basal*/diff 0 0.001 0.001 \ "" white black 312.25 -3.4338 0 simundump kreac /kinetics/chain/kinetics[6]/PKC/PKC-basal-act 0 1 50 "" white \ blue 311.02 -8.9429 0 simundump kpool /kinetics/chain/kinetics[6]/PKC/PKC-AA* 0 -1e-12 1.8134e-17 \ 1.8134e-17 1.3672e-12 1.3672e-12 0 0 75396 0 /kinetics/dendgeom cyan blue \ 317.78 -5.1793 0 simundump kreac /kinetics/chain/kinetics[6]/PKC/PKC-AA*/diff 0 0.001 0.001 "" \ white black 318.78 -2.1793 0 simundump kreac /kinetics/chain/kinetics[6]/PKC/PKC-act-by-AA 0 1.5916e-09 \ 0.1 "" white blue 311.01 -13.865 0 simundump kpool /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG 0 -1e-12 \ 8.4632e-23 8.4632e-23 6.3809e-18 6.3809e-18 0 0 75396 0 /kinetics/dendgeom \ white blue 316.23 -10.197 0 simundump kreac /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG/diff 0 0.001 0.001 \ "" white black 317.23 -7.197 0 simundump kreac /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 312.99 -13.99 0 simundump kpool /kinetics/chain/kinetics[6]/PKC/PKC-DAG 0 -1e-12 1.161e-16 \ 1.161e-16 8.7535e-12 8.7535e-12 0 0 75396 0 /kinetics/dendgeom white blue \ 315 -13.086 0 simundump kreac /kinetics/chain/kinetics[6]/PKC/PKC-DAG/diff 0 0.001 0.001 "" \ white black 316 -10.086 0 simundump kreac /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG-AA 0 2.3874e-07 2 \ "" white blue 314.77 -14.953 0 simundump kpool /kinetics/chain/kinetics[6]/PKC/PKC-DAG-AA 0 -1e-12 \ 2.5188e-19 2.5188e-19 1.8991e-14 1.8991e-14 0 0 75396 0 /kinetics/dendgeom \ white blue 316.62 -11.773 0 simundump kreac /kinetics/chain/kinetics[6]/PKC/PKC-DAG-AA/diff 0 0.001 0.001 \ "" white black 317.62 -8.773 0 simundump kpool /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic 0 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom white blue 309.87 -11.403 0 simundump kreac /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic/diff 0 0.001 \ 0.001 "" white black 310.87 -8.403 0 simundump kpool /kinetics/chain/kinetics[6]/AA 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom darkgreen black 312.71 -21.338 0 simundump kreac /kinetics/chain/kinetics[6]/AA/diff 0 0.001 0.001 "" white \ black 313.71 -18.338 0 simundump group /kinetics/chain/kinetics[6]/PLA2 0 darkgreen black x 0 1 "" \ defaultfile defaultfile.g 0 0 0 308.64 -26.209 0 simundump kpool /kinetics/chain/kinetics[6]/PLA2/PLA2-cytosolic 0 -1e-12 \ 0.39999 0.39999 30158 30158 0 0 75396 0 /kinetics/dendgeom yellow darkgreen \ 304.18 -20.942 0 simundump kreac /kinetics/chain/kinetics[6]/PLA2/PLA2-cytosolic/diff 0 0.001 \ 0.001 "" white black 305.18 -17.942 0 simundump kreac /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca-act 0 1.3263e-05 0.1 \ "" white darkgreen 304.9 -23.104 0 simundump kpool /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom yellow darkgreen 307.28 -23.646 0 simundump kenz /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca*/kenz 0 0 0 0 0 75396 \ 1.7906e-05 21.6 5.4 0 0 "" red yellow "" 309.94 -23.667 0 simundump kreac /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca*/diff 0 0.001 0.001 \ "" white black 308.28 -20.646 0 simundump kreac /kinetics/chain/kinetics[6]/PLA2/PIP2-PLA2-act 0 1.5916e-08 \ 0.5 "" white darkgreen 304.95 -18.75 0 simundump kpool /kinetics/chain/kinetics[6]/PLA2/PIP2-PLA2* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 307.32 -18.292 0 simundump kenz /kinetics/chain/kinetics[6]/PLA2/PIP2-PLA2*/kenz 0 0 0 0 0 \ 75396 3.6607e-05 44.16 11.04 0 0 "" red cyan "" 309.97 -18.271 0 simundump kreac /kinetics/chain/kinetics[6]/PLA2/PIP2-PLA2*/diff 0 0.001 \ 0.001 "" white black 308.32 -15.292 0 simundump kreac /kinetics/chain/kinetics[6]/PLA2/PIP2-Ca-PLA2-act 0 \ 1.5916e-07 0.1 "" white darkgreen 305.9 -19.5 0 simundump kpool /kinetics/chain/kinetics[6]/PLA2/PIP2-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 307.67 -19.896 0 simundump kenz /kinetics/chain/kinetics[6]/PLA2/PIP2-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00011937 144 36 0 0 "" red cyan "" 310.03 -19.979 0 simundump kreac /kinetics/chain/kinetics[6]/PLA2/PIP2-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 308.67 -16.896 0 simundump kreac /kinetics/chain/kinetics[6]/PLA2/DAG-Ca-PLA2-act 0 3.979e-08 \ 4 "" white darkgreen 305.17 -21.834 0 simundump kpool /kinetics/chain/kinetics[6]/PLA2/DAG-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom pink darkgreen 307.86 -22.479 0 simundump kenz /kinetics/chain/kinetics[6]/PLA2/DAG-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00019895 240 60 0 0 "" red pink "" 310.05 -22.354 0 simundump kreac /kinetics/chain/kinetics[6]/PLA2/DAG-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 308.86 -19.479 0 simundump kpool /kinetics/chain/kinetics[6]/PLA2/APC 0 -1e-12 30 30 \ 2.2619e+06 2.2619e+06 0 0 75396 4 /kinetics/dendgeom yellow darkgreen \ 307.76 -21.963 0 simundump kreac /kinetics/chain/kinetics[6]/PLA2/Degrade-AA 1 0.4 0 "" white \ darkgreen 309.82 -17.288 0 simundump kpool /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange darkgreen 308.19 -24.687 0 simundump kenz /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca/kenz 0 0 0 0 0 75396 \ 0.0003979 480 120 0 0 "" red orange "" 309.92 -24.817 0 simundump kreac /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca/diff 0 0.001 0.001 \ "" white black 309.19 -21.687 0 simundump kpool /kinetics/chain/kinetics[6]/PLA2/PLA2* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange darkgreen 306.98 -26.851 0 simundump kreac /kinetics/chain/kinetics[6]/PLA2/PLA2*/diff 0 0.001 0.001 "" \ white black 307.98 -23.851 0 simundump kreac /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca-act 1 7.958e-05 0.1 \ "" white darkgreen 305.91 -24.752 0 simundump kreac /kinetics/chain/kinetics[6]/PLA2/dephosphorylate-PLA2* 1 0.17 \ 0 "" white darkgreen 302.31 -23.735 0 simundump kpool /kinetics/chain/kinetics[6]/temp-PIP2 1 -1e-12 2.5 2.5 \ 1.8849e+05 1.8849e+05 0 0 75396 4 /kinetics/dendgeom green black 300.2 \ -19.047 0 simundump group /kinetics/chain/kinetics[6]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 331 -1 0 simundump kpool /kinetics/chain/kinetics[6]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 322 -4 0 simundump kpool /kinetics/chain/kinetics[6]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 325 -4 0 simundump kpool /kinetics/chain/kinetics[6]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 322 -8 0 simundump kpool /kinetics/chain/kinetics[6]/MAPK/MAPK 0 -1e-12 3.5999 3.5999 \ 2.7142e+05 2.7142e+05 0 0 75396 0 /kinetics/dendgeom pink brown 322 -11 0 simundump kreac /kinetics/chain/kinetics[6]/MAPK/MAPK/diff 0 0.001 0.001 "" \ white black 323 -8 0 simundump kpool /kinetics/chain/kinetics[6]/MAPK/craf-1** 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink brown 328 -4 0 simundump kpool /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr 1 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange brown 325 -11 0 simundump kreac /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr/diff 0 0.001 0.001 \ "" white black 326 -8 0 simundump kpool /kinetics/chain/kinetics[6]/MAPK/MAPKK* 0 0 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom pink brown 329 -8 0 simundump kenz /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 324 -9 0 simundump kenz /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 329 -9 0 simundump kpool /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 325 -8 0 simundump kpool /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 321 -6 0 simundump kenz /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 0 \ 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 324 -6 0 simundump kenz /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 0 \ 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 327 -6 0 simundump kpool /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red brown 321 -7 0 simundump kenz /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 324 -7 0 simundump kenz /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 327 -7 0 simundump kreac /kinetics/chain/kinetics[6]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 319 -3 0 simundump group /kinetics/chain/kinetics[6]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 330.51 4.351 0 simundump kreac /kinetics/chain/kinetics[6]/Ras/dephosph-GEF 1 1 0 "" white \ blue 325.07 5.881 0 simundump kpool /kinetics/chain/kinetics[6]/Ras/inact-GEF 1 -1e-12 0.1 0.1 \ 7539.6 7539.6 0 0 75396 0 /kinetics/dendgeom hotpink blue 328.45 6.352 0 simundump kenz /kinetics/chain/kinetics[6]/Ras/inact-GEF/basal_GEF_activity 0 \ 0 0 0 0 75396 1.313e-07 0.08 0.02 0 0 "" red hotpink "" 327 5 0 simundump kreac /kinetics/chain/kinetics[6]/Ras/inact-GEF/diff 0 0.001 0.001 \ "" white black 329.45 9.352 0 simundump kpool /kinetics/chain/kinetics[6]/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 322.45 5.246 0 simundump kenz /kinetics/chain/kinetics[6]/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 \ 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 323.08 4.086 0 simundump kreac /kinetics/chain/kinetics[6]/Ras/GEF*/diff 0 0.001 0.001 "" \ white black 323.45 8.246 0 simundump kpool /kinetics/chain/kinetics[6]/Ras/GTP-Ras 1 0 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange blue 328.56 1.084 0 simundump kpool /kinetics/chain/kinetics[6]/Ras/GDP-Ras 1 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink blue 322.13 2.165 0 simundump kreac /kinetics/chain/kinetics[6]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 325.1 1.5 0 simundump kreac /kinetics/chain/kinetics[6]/Ras/dephosph-GAP 1 0.1 0 "" white \ blue 320.02 3.524 0 simundump kpool /kinetics/chain/kinetics[6]/Ras/GAP* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red blue 317.35 2.349 0 simundump kreac /kinetics/chain/kinetics[6]/Ras/GAP*/diff 0 0.001 0.001 "" \ white black 318.35 5.349 0 simundump kpool /kinetics/chain/kinetics[6]/Ras/GAP 1 -1e-12 0.01 0.01 753.96 \ 753.96 0 0 75396 0 /kinetics/dendgeom red blue 322.65 0.338 0 simundump kenz /kinetics/chain/kinetics[6]/Ras/GAP/GAP-inact-ras 1 0 0 0 0 \ 75396 0.00065634 40 10 0 0 "" red red "" 325.01 0.403 0 simundump kreac /kinetics/chain/kinetics[6]/Ras/GAP/diff 0 0.001 0.001 "" \ white black 323.65 3.338 0 simundump kreac /kinetics/chain/kinetics[6]/Ras/CaM-bind-GEF 1 0.0026526 1 "" \ white blue 318.49 9.679 0 simundump kpool /kinetics/chain/kinetics[6]/Ras/CaM-GEF 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 321.35 7.58 0 simundump kenz /kinetics/chain/kinetics[6]/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 \ 0 0 75396 1.3131e-05 0.4 0.1 0 0 "" red pink "" 321.02 6.657 0 simundump kreac /kinetics/chain/kinetics[6]/Ras/CaM-GEF/diff 0 0.001 0.001 "" \ white black 322.35 10.58 0 simundump kpool /kinetics/chain/kinetics[6]/Ca 1 -1e-12 0.095 0.095 7162.6 \ 7162.6 0 0 75396 4 /kinetics/dendgeom red black 301 -13 0 simundump kpool /kinetics/chain/kinetics[6]/DAG 1 -1e-12 12.2 12.2 9.1983e+05 \ 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 316.72 -19.562 0 simundump kpool /kinetics/chain/kinetics[6]/PKC-active 1 -1e-12 0.3 \ 2.1196e-16 1.5981e-11 22619 0 0 75396 2 /kinetics/dendgeom red black 316 -3 \ 0 simundump kenz /kinetics/chain/kinetics[6]/PKC-active/PKC-act-raf 1 0 0 0 0 \ 75396 3.979e-06 16 4 0 0 "" red yellow "" 322 -2 0 simundump kenz /kinetics/chain/kinetics[6]/PKC-active/PKC-inact-GAP 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 320 1 0 simundump kenz /kinetics/chain/kinetics[6]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 325 8 0 simundump kenz /kinetics/chain/kinetics[6]/PKC-active/phosph-AC2 1 0 0 0 0 \ 75396 0.00066667 16 4 0 0 "" red red "" 309.32 -23.269 0 simundump kpool /kinetics/chain/kinetics[6]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 329 -11 0 simundump kenz /kinetics/chain/kinetics[6]/MAPK*/MAPK* 0 0 0 0 0 75396 \ 2.5864e-05 40 10 0 0 "" red orange "" 304 -26 0 simundump kenz /kinetics/chain/kinetics[6]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange "" 326 -2 0 simundump kreac /kinetics/chain/kinetics[6]/MAPK*/diff 0 0.001 0.001 "" white \ black 330 -8 0 simundump kpool /kinetics/chain/kinetics[6]/IP3 1 -1e-12 0.73 0.73 55039 \ 55039 0 0 75396 4 /kinetics/dendgeom pink black 315.23 -16.656 0 simundump kpool /kinetics/chain/kinetics[6]/MKP-1 1 -1e-12 0.024 0.024 1809.5 \ 1809.5 0 0 75396 0 /kinetics/dendgeom hotpink black 321 -10 0 simundump kenz /kinetics/chain/kinetics[6]/MKP-1/MKP1-tyr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 322 -9 0 simundump kenz /kinetics/chain/kinetics[6]/MKP-1/MKP1-thr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 327 -9 0 simundump kreac /kinetics/chain/kinetics[6]/MKP-1/diff 0 0.001 0.001 "" white \ black 322 -7 0 simundump kpool /kinetics/chain/kinetics[6]/PPhosphatase2A 1 -1e-12 1 1 75396 \ 75396 0 0 75396 0 /kinetics/dendgeom hotpink yellow 325 -3 0 simundump kenz /kinetics/chain/kinetics[6]/PPhosphatase2A/craf-deph 1 0 0 0 0 \ 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 324 -2 0 simundump kenz /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 327 -5 0 simundump kenz /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph-ser 1 0 \ 0 0 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 324 -5 0 simundump kenz /kinetics/chain/kinetics[6]/PPhosphatase2A/craf**-deph 1 0 0 0 \ 0 0.12566 2.5414e-05 24 6 0 0 "" red hotpink "" 328 -2 0 simundump kreac /kinetics/chain/kinetics[6]/PPhosphatase2A/diff 0 0.001 0.001 \ "" white black 326 0 0 simundump group /kinetics/chain/kinetics[6]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 303 -9 0 simundump kpool /kinetics/chain/kinetics[6]/CaM/CaM 1 -1e-12 20 20 1.5079e+06 \ 1.5079e+06 0 0 75396 0 /kinetics/dendgeom pink blue 302.98 -1.28 0 simundump kreac /kinetics/chain/kinetics[6]/CaM/CaM/diff 0 0.001 0.001 "" \ white black 303.98 1.72 0 simundump kreac /kinetics/chain/kinetics[6]/CaM/CaM-TR2-bind-Ca 1 1.2666e-08 \ 72 "" white blue 305.16 -1.921 0 simundump kreac /kinetics/chain/kinetics[6]/CaM/CaM-TR2-Ca2-bind-Ca 1 \ 4.7748e-05 10 "" white blue 304.16 -3.7747 0 simundump kreac /kinetics/chain/kinetics[6]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 302.6 -6.7404 0 simundump kpool /kinetics/chain/kinetics[6]/CaM/CaM-Ca3 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 306.49 -5.603 0 simundump kreac /kinetics/chain/kinetics[6]/CaM/CaM-Ca3/diff 0 0.001 0.001 "" \ white black 307.49 -2.603 0 simundump kpool /kinetics/chain/kinetics[6]/CaM/CaM-TR2-Ca2 1 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 308 -2.7423 0 simundump kreac /kinetics/chain/kinetics[6]/CaM/CaM-TR2-Ca2/diff 0 0.001 \ 0.001 "" white black 309 0.2577 0 simundump kpool /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom blue blue 308 -8 0 simundump kreac /kinetics/chain/kinetics[6]/CaM/CaM-Ca4/diff 0 0.001 0.001 "" \ white black 309 -5 0 simundump kreac /kinetics/chain/kinetics[6]/Ras-act-unphosph-raf 0 7.958e-05 \ 1 "" white black 320 -4 0 simundump kpool /kinetics/chain/kinetics[6]/Ca_input 0 -1e-12 0.08 0.08 \ 6031.7 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 294 -7 0 simundump kreac /kinetics/chain/kinetics[6]/Ca_diff 0 2 2 "" white black 295 \ -12 0 simundump group /kinetics/chain/kinetics[7] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 354 0 0 simundump group /kinetics/chain/kinetics[7]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 362.95 -3.7837 0 simundump kpool /kinetics/chain/kinetics[7]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 361.92 -10.489 0 simundump kreac /kinetics/chain/kinetics[7]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 362.92 -7.489 0 simundump kreac /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca 0 7.958e-06 0.5 \ "" white blue 361.92 -12.123 0 simundump kreac /kinetics/chain/kinetics[7]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 363.94 -11.306 0 simundump kreac /kinetics/chain/kinetics[7]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 362.2 -7.7467 0 simundump kreac /kinetics/chain/kinetics[7]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 363.38 -9.2638 0 simundump kreac /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca-AA 0 1.5916e-08 \ 0.1 "" white blue 365.21 -8.1843 0 simundump kreac /kinetics/chain/kinetics[7]/PKC/PKC-act-by-DAG-AA 0 2 0.2 "" \ white blue 367.25 -8.7678 0 simundump kpool /kinetics/chain/kinetics[7]/PKC/PKC-DAG-AA* 0 -1e-12 \ 4.9137e-18 4.9137e-18 3.7047e-13 3.7047e-13 0 0 75396 0 /kinetics/dendgeom \ cyan blue 366.6 -6.463 0 simundump kreac /kinetics/chain/kinetics[7]/PKC/PKC-DAG-AA*/diff 0 0.001 \ 0.001 "" white black 367.6 -3.463 0 simundump kpool /kinetics/chain/kinetics[7]/PKC/PKC-Ca-AA* 0 -1e-12 \ 1.7501e-16 1.7501e-16 1.3195e-11 1.3195e-11 0 0 75396 0 /kinetics/dendgeom \ orange blue 365.4 -5.7044 0 simundump kreac /kinetics/chain/kinetics[7]/PKC/PKC-Ca-AA*/diff 0 0.001 0.001 \ "" white black 366.4 -2.7044 0 simundump kpool /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb* 0 -1e-12 \ 1.3896e-17 1.3896e-17 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom \ pink blue 363.22 -5.471 0 simundump kreac /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb*/diff 0 0.001 \ 0.001 "" white black 364.22 -2.471 0 simundump kpool /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb* 0 -1e-12 \ 9.4351e-21 9.4351e-21 7.1137e-16 7.1137e-16 0 0 75396 0 /kinetics/dendgeom \ yellow blue 364.17 -6.4922 0 simundump kreac /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb*/diff 0 0.001 \ 0.001 "" white black 365.17 -3.4922 0 simundump kpool /kinetics/chain/kinetics[7]/PKC/PKC-basal* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom pink blue 361.25 -6.4338 0 simundump kreac /kinetics/chain/kinetics[7]/PKC/PKC-basal*/diff 0 0.001 0.001 \ "" white black 362.25 -3.4338 0 simundump kreac /kinetics/chain/kinetics[7]/PKC/PKC-basal-act 0 1 50 "" white \ blue 361.02 -8.9429 0 simundump kpool /kinetics/chain/kinetics[7]/PKC/PKC-AA* 0 -1e-12 1.8134e-17 \ 1.8134e-17 1.3672e-12 1.3672e-12 0 0 75396 0 /kinetics/dendgeom cyan blue \ 367.78 -5.1793 0 simundump kreac /kinetics/chain/kinetics[7]/PKC/PKC-AA*/diff 0 0.001 0.001 "" \ white black 368.78 -2.1793 0 simundump kreac /kinetics/chain/kinetics[7]/PKC/PKC-act-by-AA 0 1.5916e-09 \ 0.1 "" white blue 361.01 -13.865 0 simundump kpool /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG 0 -1e-12 \ 8.4632e-23 8.4632e-23 6.3809e-18 6.3809e-18 0 0 75396 0 /kinetics/dendgeom \ white blue 366.23 -10.197 0 simundump kreac /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG/diff 0 0.001 0.001 \ "" white black 367.23 -7.197 0 simundump kreac /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 362.99 -13.99 0 simundump kpool /kinetics/chain/kinetics[7]/PKC/PKC-DAG 0 -1e-12 1.161e-16 \ 1.161e-16 8.7535e-12 8.7535e-12 0 0 75396 0 /kinetics/dendgeom white blue \ 365 -13.086 0 simundump kreac /kinetics/chain/kinetics[7]/PKC/PKC-DAG/diff 0 0.001 0.001 "" \ white black 366 -10.086 0 simundump kreac /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG-AA 0 2.3874e-07 2 \ "" white blue 364.77 -14.953 0 simundump kpool /kinetics/chain/kinetics[7]/PKC/PKC-DAG-AA 0 -1e-12 \ 2.5188e-19 2.5188e-19 1.8991e-14 1.8991e-14 0 0 75396 0 /kinetics/dendgeom \ white blue 366.62 -11.773 0 simundump kreac /kinetics/chain/kinetics[7]/PKC/PKC-DAG-AA/diff 0 0.001 0.001 \ "" white black 367.62 -8.773 0 simundump kpool /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic 0 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom white blue 359.87 -11.403 0 simundump kreac /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic/diff 0 0.001 \ 0.001 "" white black 360.87 -8.403 0 simundump kpool /kinetics/chain/kinetics[7]/AA 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom darkgreen black 362.71 -21.338 0 simundump kreac /kinetics/chain/kinetics[7]/AA/diff 0 0.001 0.001 "" white \ black 363.71 -18.338 0 simundump group /kinetics/chain/kinetics[7]/PLA2 0 darkgreen black x 0 1 "" \ defaultfile defaultfile.g 0 0 0 358.64 -26.209 0 simundump kpool /kinetics/chain/kinetics[7]/PLA2/PLA2-cytosolic 0 -1e-12 \ 0.39999 0.39999 30158 30158 0 0 75396 0 /kinetics/dendgeom yellow darkgreen \ 354.18 -20.942 0 simundump kreac /kinetics/chain/kinetics[7]/PLA2/PLA2-cytosolic/diff 0 0.001 \ 0.001 "" white black 355.18 -17.942 0 simundump kreac /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca-act 0 1.3263e-05 0.1 \ "" white darkgreen 354.9 -23.104 0 simundump kpool /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom yellow darkgreen 357.28 -23.646 0 simundump kenz /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca*/kenz 0 0 0 0 0 75396 \ 1.7906e-05 21.6 5.4 0 0 "" red yellow "" 359.94 -23.667 0 simundump kreac /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca*/diff 0 0.001 0.001 \ "" white black 358.28 -20.646 0 simundump kreac /kinetics/chain/kinetics[7]/PLA2/PIP2-PLA2-act 0 1.5916e-08 \ 0.5 "" white darkgreen 354.95 -18.75 0 simundump kpool /kinetics/chain/kinetics[7]/PLA2/PIP2-PLA2* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 357.32 -18.292 0 simundump kenz /kinetics/chain/kinetics[7]/PLA2/PIP2-PLA2*/kenz 0 0 0 0 0 \ 75396 3.6607e-05 44.16 11.04 0 0 "" red cyan "" 359.97 -18.271 0 simundump kreac /kinetics/chain/kinetics[7]/PLA2/PIP2-PLA2*/diff 0 0.001 \ 0.001 "" white black 358.32 -15.292 0 simundump kreac /kinetics/chain/kinetics[7]/PLA2/PIP2-Ca-PLA2-act 0 \ 1.5916e-07 0.1 "" white darkgreen 355.9 -19.5 0 simundump kpool /kinetics/chain/kinetics[7]/PLA2/PIP2-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 357.67 -19.896 0 simundump kenz /kinetics/chain/kinetics[7]/PLA2/PIP2-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00011937 144 36 0 0 "" red cyan "" 360.03 -19.979 0 simundump kreac /kinetics/chain/kinetics[7]/PLA2/PIP2-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 358.67 -16.896 0 simundump kreac /kinetics/chain/kinetics[7]/PLA2/DAG-Ca-PLA2-act 0 3.979e-08 \ 4 "" white darkgreen 355.17 -21.834 0 simundump kpool /kinetics/chain/kinetics[7]/PLA2/DAG-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom pink darkgreen 357.86 -22.479 0 simundump kenz /kinetics/chain/kinetics[7]/PLA2/DAG-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00019895 240 60 0 0 "" red pink "" 360.05 -22.354 0 simundump kreac /kinetics/chain/kinetics[7]/PLA2/DAG-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 358.86 -19.479 0 simundump kpool /kinetics/chain/kinetics[7]/PLA2/APC 0 -1e-12 30 30 \ 2.2619e+06 2.2619e+06 0 0 75396 4 /kinetics/dendgeom yellow darkgreen \ 357.76 -21.963 0 simundump kreac /kinetics/chain/kinetics[7]/PLA2/Degrade-AA 1 0.4 0 "" white \ darkgreen 359.82 -17.288 0 simundump kpool /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange darkgreen 358.19 -24.687 0 simundump kenz /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca/kenz 0 0 0 0 0 75396 \ 0.0003979 480 120 0 0 "" red orange "" 359.92 -24.817 0 simundump kreac /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca/diff 0 0.001 0.001 \ "" white black 359.19 -21.687 0 simundump kpool /kinetics/chain/kinetics[7]/PLA2/PLA2* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange darkgreen 356.98 -26.851 0 simundump kreac /kinetics/chain/kinetics[7]/PLA2/PLA2*/diff 0 0.001 0.001 "" \ white black 357.98 -23.851 0 simundump kreac /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca-act 1 7.958e-05 0.1 \ "" white darkgreen 355.91 -24.752 0 simundump kreac /kinetics/chain/kinetics[7]/PLA2/dephosphorylate-PLA2* 1 0.17 \ 0 "" white darkgreen 352.31 -23.735 0 simundump kpool /kinetics/chain/kinetics[7]/temp-PIP2 1 -1e-12 2.5 2.5 \ 1.8849e+05 1.8849e+05 0 0 75396 4 /kinetics/dendgeom green black 350.2 \ -19.047 0 simundump group /kinetics/chain/kinetics[7]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 381 -1 0 simundump kpool /kinetics/chain/kinetics[7]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 372 -4 0 simundump kpool /kinetics/chain/kinetics[7]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 375 -4 0 simundump kpool /kinetics/chain/kinetics[7]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 372 -8 0 simundump kpool /kinetics/chain/kinetics[7]/MAPK/MAPK 0 -1e-12 3.5999 3.5999 \ 2.7142e+05 2.7142e+05 0 0 75396 0 /kinetics/dendgeom pink brown 372 -11 0 simundump kreac /kinetics/chain/kinetics[7]/MAPK/MAPK/diff 0 0.001 0.001 "" \ white black 373 -8 0 simundump kpool /kinetics/chain/kinetics[7]/MAPK/craf-1** 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink brown 378 -4 0 simundump kpool /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr 1 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange brown 375 -11 0 simundump kreac /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr/diff 0 0.001 0.001 \ "" white black 376 -8 0 simundump kpool /kinetics/chain/kinetics[7]/MAPK/MAPKK* 0 0 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom pink brown 379 -8 0 simundump kenz /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 374 -9 0 simundump kenz /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 379 -9 0 simundump kpool /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 375 -8 0 simundump kpool /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 371 -6 0 simundump kenz /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 0 \ 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 374 -6 0 simundump kenz /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 0 \ 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 377 -6 0 simundump kpool /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red brown 371 -7 0 simundump kenz /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 374 -7 0 simundump kenz /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 377 -7 0 simundump kreac /kinetics/chain/kinetics[7]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 369 -3 0 simundump group /kinetics/chain/kinetics[7]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 380.51 4.351 0 simundump kreac /kinetics/chain/kinetics[7]/Ras/dephosph-GEF 1 1 0 "" white \ blue 375.07 5.881 0 simundump kpool /kinetics/chain/kinetics[7]/Ras/inact-GEF 1 -1e-12 0.1 0.1 \ 7539.6 7539.6 0 0 75396 0 /kinetics/dendgeom hotpink blue 378.45 6.352 0 simundump kenz /kinetics/chain/kinetics[7]/Ras/inact-GEF/basal_GEF_activity 0 \ 0 0 0 0 75396 1.313e-07 0.08 0.02 0 0 "" red hotpink "" 377 5 0 simundump kreac /kinetics/chain/kinetics[7]/Ras/inact-GEF/diff 0 0.001 0.001 \ "" white black 379.45 9.352 0 simundump kpool /kinetics/chain/kinetics[7]/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 372.45 5.246 0 simundump kenz /kinetics/chain/kinetics[7]/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 \ 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 373.08 4.086 0 simundump kreac /kinetics/chain/kinetics[7]/Ras/GEF*/diff 0 0.001 0.001 "" \ white black 373.45 8.246 0 simundump kpool /kinetics/chain/kinetics[7]/Ras/GTP-Ras 1 0 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange blue 378.56 1.084 0 simundump kpool /kinetics/chain/kinetics[7]/Ras/GDP-Ras 1 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink blue 372.13 2.165 0 simundump kreac /kinetics/chain/kinetics[7]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 375.1 1.5 0 simundump kreac /kinetics/chain/kinetics[7]/Ras/dephosph-GAP 1 0.1 0 "" white \ blue 370.02 3.524 0 simundump kpool /kinetics/chain/kinetics[7]/Ras/GAP* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red blue 367.35 2.349 0 simundump kreac /kinetics/chain/kinetics[7]/Ras/GAP*/diff 0 0.001 0.001 "" \ white black 368.35 5.349 0 simundump kpool /kinetics/chain/kinetics[7]/Ras/GAP 1 -1e-12 0.01 0.01 753.96 \ 753.96 0 0 75396 0 /kinetics/dendgeom red blue 372.65 0.338 0 simundump kenz /kinetics/chain/kinetics[7]/Ras/GAP/GAP-inact-ras 1 0 0 0 0 \ 75396 0.00065634 40 10 0 0 "" red red "" 375.01 0.403 0 simundump kreac /kinetics/chain/kinetics[7]/Ras/GAP/diff 0 0.001 0.001 "" \ white black 373.65 3.338 0 simundump kreac /kinetics/chain/kinetics[7]/Ras/CaM-bind-GEF 1 0.0026526 1 "" \ white blue 368.49 9.679 0 simundump kpool /kinetics/chain/kinetics[7]/Ras/CaM-GEF 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 371.35 7.58 0 simundump kenz /kinetics/chain/kinetics[7]/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 \ 0 0 75396 1.3131e-05 0.4 0.1 0 0 "" red pink "" 371.02 6.657 0 simundump kreac /kinetics/chain/kinetics[7]/Ras/CaM-GEF/diff 0 0.001 0.001 "" \ white black 372.35 10.58 0 simundump kpool /kinetics/chain/kinetics[7]/Ca 1 -1e-12 0.095 0.095 7162.6 \ 7162.6 0 0 75396 4 /kinetics/dendgeom red black 351 -13 0 simundump kpool /kinetics/chain/kinetics[7]/DAG 1 -1e-12 12.2 12.2 9.1983e+05 \ 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 366.72 -19.562 0 simundump kpool /kinetics/chain/kinetics[7]/PKC-active 1 -1e-12 0.3 \ 2.1196e-16 1.5981e-11 22619 0 0 75396 2 /kinetics/dendgeom red black 366 -3 \ 0 simundump kenz /kinetics/chain/kinetics[7]/PKC-active/PKC-act-raf 1 0 0 0 0 \ 75396 3.979e-06 16 4 0 0 "" red yellow "" 372 -2 0 simundump kenz /kinetics/chain/kinetics[7]/PKC-active/PKC-inact-GAP 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 370 1 0 simundump kenz /kinetics/chain/kinetics[7]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 375 8 0 simundump kenz /kinetics/chain/kinetics[7]/PKC-active/phosph-AC2 1 0 0 0 0 \ 75396 0.00066667 16 4 0 0 "" red red "" 359.32 -23.269 0 simundump kpool /kinetics/chain/kinetics[7]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 379 -11 0 simundump kenz /kinetics/chain/kinetics[7]/MAPK*/MAPK* 0 0 0 0 0 75396 \ 2.5864e-05 40 10 0 0 "" red orange "" 354 -26 0 simundump kenz /kinetics/chain/kinetics[7]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange "" 376 -2 0 simundump kreac /kinetics/chain/kinetics[7]/MAPK*/diff 0 0.001 0.001 "" white \ black 380 -8 0 simundump kpool /kinetics/chain/kinetics[7]/IP3 1 -1e-12 0.73 0.73 55039 \ 55039 0 0 75396 4 /kinetics/dendgeom pink black 365.23 -16.656 0 simundump kpool /kinetics/chain/kinetics[7]/MKP-1 1 -1e-12 0.024 0.024 1809.5 \ 1809.5 0 0 75396 0 /kinetics/dendgeom hotpink black 371 -10 0 simundump kenz /kinetics/chain/kinetics[7]/MKP-1/MKP1-tyr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 372 -9 0 simundump kenz /kinetics/chain/kinetics[7]/MKP-1/MKP1-thr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 377 -9 0 simundump kreac /kinetics/chain/kinetics[7]/MKP-1/diff 0 0.001 0.001 "" white \ black 372 -7 0 simundump kpool /kinetics/chain/kinetics[7]/PPhosphatase2A 1 -1e-12 1 1 75396 \ 75396 0 0 75396 0 /kinetics/dendgeom hotpink yellow 375 -3 0 simundump kenz /kinetics/chain/kinetics[7]/PPhosphatase2A/craf-deph 1 0 0 0 0 \ 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 374 -2 0 simundump kenz /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 377 -5 0 simundump kenz /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph-ser 1 0 \ 0 0 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 374 -5 0 simundump kenz /kinetics/chain/kinetics[7]/PPhosphatase2A/craf**-deph 1 0 0 0 \ 0 0.12566 2.5414e-05 24 6 0 0 "" red hotpink "" 378 -2 0 simundump kreac /kinetics/chain/kinetics[7]/PPhosphatase2A/diff 0 0.001 0.001 \ "" white black 376 0 0 simundump group /kinetics/chain/kinetics[7]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 353 -9 0 simundump kpool /kinetics/chain/kinetics[7]/CaM/CaM 1 -1e-12 20 20 1.5079e+06 \ 1.5079e+06 0 0 75396 0 /kinetics/dendgeom pink blue 352.98 -1.28 0 simundump kreac /kinetics/chain/kinetics[7]/CaM/CaM/diff 0 0.001 0.001 "" \ white black 353.98 1.72 0 simundump kreac /kinetics/chain/kinetics[7]/CaM/CaM-TR2-bind-Ca 1 1.2666e-08 \ 72 "" white blue 355.16 -1.921 0 simundump kreac /kinetics/chain/kinetics[7]/CaM/CaM-TR2-Ca2-bind-Ca 1 \ 4.7748e-05 10 "" white blue 354.16 -3.7747 0 simundump kreac /kinetics/chain/kinetics[7]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 352.6 -6.7404 0 simundump kpool /kinetics/chain/kinetics[7]/CaM/CaM-Ca3 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 356.49 -5.603 0 simundump kreac /kinetics/chain/kinetics[7]/CaM/CaM-Ca3/diff 0 0.001 0.001 "" \ white black 357.49 -2.603 0 simundump kpool /kinetics/chain/kinetics[7]/CaM/CaM-TR2-Ca2 1 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 358 -2.7423 0 simundump kreac /kinetics/chain/kinetics[7]/CaM/CaM-TR2-Ca2/diff 0 0.001 \ 0.001 "" white black 359 0.2577 0 simundump kpool /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom blue blue 358 -8 0 simundump kreac /kinetics/chain/kinetics[7]/CaM/CaM-Ca4/diff 0 0.001 0.001 "" \ white black 359 -5 0 simundump kreac /kinetics/chain/kinetics[7]/Ras-act-unphosph-raf 0 7.958e-05 \ 1 "" white black 370 -4 0 simundump kpool /kinetics/chain/kinetics[7]/Ca_input 0 -1e-12 0.08 0.08 \ 6031.7 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 344 -7 0 simundump kreac /kinetics/chain/kinetics[7]/Ca_diff 0 2 2 "" white black 345 \ -12 0 simundump group /kinetics/chain/kinetics[8] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 404 0 0 simundump group /kinetics/chain/kinetics[8]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 412.95 -3.7837 0 simundump kpool /kinetics/chain/kinetics[8]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 411.92 -10.489 0 simundump kreac /kinetics/chain/kinetics[8]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 412.92 -7.489 0 simundump kreac /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca 0 7.958e-06 0.5 \ "" white blue 411.92 -12.123 0 simundump kreac /kinetics/chain/kinetics[8]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 413.94 -11.306 0 simundump kreac /kinetics/chain/kinetics[8]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 412.2 -7.7467 0 simundump kreac /kinetics/chain/kinetics[8]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 413.38 -9.2638 0 simundump kreac /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca-AA 0 1.5916e-08 \ 0.1 "" white blue 415.21 -8.1843 0 simundump kreac /kinetics/chain/kinetics[8]/PKC/PKC-act-by-DAG-AA 0 2 0.2 "" \ white blue 417.25 -8.7678 0 simundump kpool /kinetics/chain/kinetics[8]/PKC/PKC-DAG-AA* 0 -1e-12 \ 4.9137e-18 4.9137e-18 3.7047e-13 3.7047e-13 0 0 75396 0 /kinetics/dendgeom \ cyan blue 416.6 -6.463 0 simundump kreac /kinetics/chain/kinetics[8]/PKC/PKC-DAG-AA*/diff 0 0.001 \ 0.001 "" white black 417.6 -3.463 0 simundump kpool /kinetics/chain/kinetics[8]/PKC/PKC-Ca-AA* 0 -1e-12 \ 1.7501e-16 1.7501e-16 1.3195e-11 1.3195e-11 0 0 75396 0 /kinetics/dendgeom \ orange blue 415.4 -5.7044 0 simundump kreac /kinetics/chain/kinetics[8]/PKC/PKC-Ca-AA*/diff 0 0.001 0.001 \ "" white black 416.4 -2.7044 0 simundump kpool /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb* 0 -1e-12 \ 1.3896e-17 1.3896e-17 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom \ pink blue 413.22 -5.471 0 simundump kreac /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb*/diff 0 0.001 \ 0.001 "" white black 414.22 -2.471 0 simundump kpool /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb* 0 -1e-12 \ 9.4351e-21 9.4351e-21 7.1137e-16 7.1137e-16 0 0 75396 0 /kinetics/dendgeom \ yellow blue 414.17 -6.4922 0 simundump kreac /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb*/diff 0 0.001 \ 0.001 "" white black 415.17 -3.4922 0 simundump kpool /kinetics/chain/kinetics[8]/PKC/PKC-basal* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom pink blue 411.25 -6.4338 0 simundump kreac /kinetics/chain/kinetics[8]/PKC/PKC-basal*/diff 0 0.001 0.001 \ "" white black 412.25 -3.4338 0 simundump kreac /kinetics/chain/kinetics[8]/PKC/PKC-basal-act 0 1 50 "" white \ blue 411.02 -8.9429 0 simundump kpool /kinetics/chain/kinetics[8]/PKC/PKC-AA* 0 -1e-12 1.8134e-17 \ 1.8134e-17 1.3672e-12 1.3672e-12 0 0 75396 0 /kinetics/dendgeom cyan blue \ 417.78 -5.1793 0 simundump kreac /kinetics/chain/kinetics[8]/PKC/PKC-AA*/diff 0 0.001 0.001 "" \ white black 418.78 -2.1793 0 simundump kreac /kinetics/chain/kinetics[8]/PKC/PKC-act-by-AA 0 1.5916e-09 \ 0.1 "" white blue 411.01 -13.865 0 simundump kpool /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG 0 -1e-12 \ 8.4632e-23 8.4632e-23 6.3809e-18 6.3809e-18 0 0 75396 0 /kinetics/dendgeom \ white blue 416.23 -10.197 0 simundump kreac /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG/diff 0 0.001 0.001 \ "" white black 417.23 -7.197 0 simundump kreac /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 412.99 -13.99 0 simundump kpool /kinetics/chain/kinetics[8]/PKC/PKC-DAG 0 -1e-12 1.161e-16 \ 1.161e-16 8.7535e-12 8.7535e-12 0 0 75396 0 /kinetics/dendgeom white blue \ 415 -13.086 0 simundump kreac /kinetics/chain/kinetics[8]/PKC/PKC-DAG/diff 0 0.001 0.001 "" \ white black 416 -10.086 0 simundump kreac /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG-AA 0 2.3874e-07 2 \ "" white blue 414.77 -14.953 0 simundump kpool /kinetics/chain/kinetics[8]/PKC/PKC-DAG-AA 0 -1e-12 \ 2.5188e-19 2.5188e-19 1.8991e-14 1.8991e-14 0 0 75396 0 /kinetics/dendgeom \ white blue 416.62 -11.773 0 simundump kreac /kinetics/chain/kinetics[8]/PKC/PKC-DAG-AA/diff 0 0.001 0.001 \ "" white black 417.62 -8.773 0 simundump kpool /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic 0 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom white blue 409.87 -11.403 0 simundump kreac /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic/diff 0 0.001 \ 0.001 "" white black 410.87 -8.403 0 simundump kpool /kinetics/chain/kinetics[8]/AA 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom darkgreen black 412.71 -21.338 0 simundump kreac /kinetics/chain/kinetics[8]/AA/diff 0 0.001 0.001 "" white \ black 413.71 -18.338 0 simundump group /kinetics/chain/kinetics[8]/PLA2 0 darkgreen black x 0 1 "" \ defaultfile defaultfile.g 0 0 0 408.64 -26.209 0 simundump kpool /kinetics/chain/kinetics[8]/PLA2/PLA2-cytosolic 0 -1e-12 \ 0.39999 0.39999 30158 30158 0 0 75396 0 /kinetics/dendgeom yellow darkgreen \ 404.18 -20.942 0 simundump kreac /kinetics/chain/kinetics[8]/PLA2/PLA2-cytosolic/diff 0 0.001 \ 0.001 "" white black 405.18 -17.942 0 simundump kreac /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca-act 0 1.3263e-05 0.1 \ "" white darkgreen 404.9 -23.104 0 simundump kpool /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom yellow darkgreen 407.28 -23.646 0 simundump kenz /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca*/kenz 0 0 0 0 0 75396 \ 1.7906e-05 21.6 5.4 0 0 "" red yellow "" 409.94 -23.667 0 simundump kreac /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca*/diff 0 0.001 0.001 \ "" white black 408.28 -20.646 0 simundump kreac /kinetics/chain/kinetics[8]/PLA2/PIP2-PLA2-act 0 1.5916e-08 \ 0.5 "" white darkgreen 404.95 -18.75 0 simundump kpool /kinetics/chain/kinetics[8]/PLA2/PIP2-PLA2* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 407.32 -18.292 0 simundump kenz /kinetics/chain/kinetics[8]/PLA2/PIP2-PLA2*/kenz 0 0 0 0 0 \ 75396 3.6607e-05 44.16 11.04 0 0 "" red cyan "" 409.97 -18.271 0 simundump kreac /kinetics/chain/kinetics[8]/PLA2/PIP2-PLA2*/diff 0 0.001 \ 0.001 "" white black 408.32 -15.292 0 simundump kreac /kinetics/chain/kinetics[8]/PLA2/PIP2-Ca-PLA2-act 0 \ 1.5916e-07 0.1 "" white darkgreen 405.9 -19.5 0 simundump kpool /kinetics/chain/kinetics[8]/PLA2/PIP2-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 407.67 -19.896 0 simundump kenz /kinetics/chain/kinetics[8]/PLA2/PIP2-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00011937 144 36 0 0 "" red cyan "" 410.03 -19.979 0 simundump kreac /kinetics/chain/kinetics[8]/PLA2/PIP2-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 408.67 -16.896 0 simundump kreac /kinetics/chain/kinetics[8]/PLA2/DAG-Ca-PLA2-act 0 3.979e-08 \ 4 "" white darkgreen 405.17 -21.834 0 simundump kpool /kinetics/chain/kinetics[8]/PLA2/DAG-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom pink darkgreen 407.86 -22.479 0 simundump kenz /kinetics/chain/kinetics[8]/PLA2/DAG-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00019895 240 60 0 0 "" red pink "" 410.05 -22.354 0 simundump kreac /kinetics/chain/kinetics[8]/PLA2/DAG-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 408.86 -19.479 0 simundump kpool /kinetics/chain/kinetics[8]/PLA2/APC 0 -1e-12 30 30 \ 2.2619e+06 2.2619e+06 0 0 75396 4 /kinetics/dendgeom yellow darkgreen \ 407.76 -21.963 0 simundump kreac /kinetics/chain/kinetics[8]/PLA2/Degrade-AA 1 0.4 0 "" white \ darkgreen 409.82 -17.288 0 simundump kpool /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange darkgreen 408.19 -24.687 0 simundump kenz /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca/kenz 0 0 0 0 0 75396 \ 0.0003979 480 120 0 0 "" red orange "" 409.92 -24.817 0 simundump kreac /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca/diff 0 0.001 0.001 \ "" white black 409.19 -21.687 0 simundump kpool /kinetics/chain/kinetics[8]/PLA2/PLA2* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange darkgreen 406.98 -26.851 0 simundump kreac /kinetics/chain/kinetics[8]/PLA2/PLA2*/diff 0 0.001 0.001 "" \ white black 407.98 -23.851 0 simundump kreac /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca-act 1 7.958e-05 0.1 \ "" white darkgreen 405.91 -24.752 0 simundump kreac /kinetics/chain/kinetics[8]/PLA2/dephosphorylate-PLA2* 1 0.17 \ 0 "" white darkgreen 402.31 -23.735 0 simundump kpool /kinetics/chain/kinetics[8]/temp-PIP2 1 -1e-12 2.5 2.5 \ 1.8849e+05 1.8849e+05 0 0 75396 4 /kinetics/dendgeom green black 400.2 \ -19.047 0 simundump group /kinetics/chain/kinetics[8]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 431 -1 0 simundump kpool /kinetics/chain/kinetics[8]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 422 -4 0 simundump kpool /kinetics/chain/kinetics[8]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 425 -4 0 simundump kpool /kinetics/chain/kinetics[8]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 422 -8 0 simundump kpool /kinetics/chain/kinetics[8]/MAPK/MAPK 0 -1e-12 3.5999 3.5999 \ 2.7142e+05 2.7142e+05 0 0 75396 0 /kinetics/dendgeom pink brown 422 -11 0 simundump kreac /kinetics/chain/kinetics[8]/MAPK/MAPK/diff 0 0.001 0.001 "" \ white black 423 -8 0 simundump kpool /kinetics/chain/kinetics[8]/MAPK/craf-1** 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink brown 428 -4 0 simundump kpool /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr 1 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange brown 425 -11 0 simundump kreac /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr/diff 0 0.001 0.001 \ "" white black 426 -8 0 simundump kpool /kinetics/chain/kinetics[8]/MAPK/MAPKK* 0 0 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom pink brown 429 -8 0 simundump kenz /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 424 -9 0 simundump kenz /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 429 -9 0 simundump kpool /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 425 -8 0 simundump kpool /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 421 -6 0 simundump kenz /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 0 \ 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 424 -6 0 simundump kenz /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 0 \ 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 427 -6 0 simundump kpool /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red brown 421 -7 0 simundump kenz /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 424 -7 0 simundump kenz /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 427 -7 0 simundump kreac /kinetics/chain/kinetics[8]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 419 -3 0 simundump group /kinetics/chain/kinetics[8]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 430.51 4.351 0 simundump kreac /kinetics/chain/kinetics[8]/Ras/dephosph-GEF 1 1 0 "" white \ blue 425.07 5.881 0 simundump kpool /kinetics/chain/kinetics[8]/Ras/inact-GEF 1 -1e-12 0.1 0.1 \ 7539.6 7539.6 0 0 75396 0 /kinetics/dendgeom hotpink blue 428.45 6.352 0 simundump kenz /kinetics/chain/kinetics[8]/Ras/inact-GEF/basal_GEF_activity 0 \ 0 0 0 0 75396 1.313e-07 0.08 0.02 0 0 "" red hotpink "" 427 5 0 simundump kreac /kinetics/chain/kinetics[8]/Ras/inact-GEF/diff 0 0.001 0.001 \ "" white black 429.45 9.352 0 simundump kpool /kinetics/chain/kinetics[8]/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 422.45 5.246 0 simundump kenz /kinetics/chain/kinetics[8]/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 \ 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 423.08 4.086 0 simundump kreac /kinetics/chain/kinetics[8]/Ras/GEF*/diff 0 0.001 0.001 "" \ white black 423.45 8.246 0 simundump kpool /kinetics/chain/kinetics[8]/Ras/GTP-Ras 1 0 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange blue 428.56 1.084 0 simundump kpool /kinetics/chain/kinetics[8]/Ras/GDP-Ras 1 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink blue 422.13 2.165 0 simundump kreac /kinetics/chain/kinetics[8]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 425.1 1.5 0 simundump kreac /kinetics/chain/kinetics[8]/Ras/dephosph-GAP 1 0.1 0 "" white \ blue 420.02 3.524 0 simundump kpool /kinetics/chain/kinetics[8]/Ras/GAP* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red blue 417.35 2.349 0 simundump kreac /kinetics/chain/kinetics[8]/Ras/GAP*/diff 0 0.001 0.001 "" \ white black 418.35 5.349 0 simundump kpool /kinetics/chain/kinetics[8]/Ras/GAP 1 -1e-12 0.01 0.01 753.96 \ 753.96 0 0 75396 0 /kinetics/dendgeom red blue 422.65 0.338 0 simundump kenz /kinetics/chain/kinetics[8]/Ras/GAP/GAP-inact-ras 1 0 0 0 0 \ 75396 0.00065634 40 10 0 0 "" red red "" 425.01 0.403 0 simundump kreac /kinetics/chain/kinetics[8]/Ras/GAP/diff 0 0.001 0.001 "" \ white black 423.65 3.338 0 simundump kreac /kinetics/chain/kinetics[8]/Ras/CaM-bind-GEF 1 0.0026526 1 "" \ white blue 418.49 9.679 0 simundump kpool /kinetics/chain/kinetics[8]/Ras/CaM-GEF 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 421.35 7.58 0 simundump kenz /kinetics/chain/kinetics[8]/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 \ 0 0 75396 1.3131e-05 0.4 0.1 0 0 "" red pink "" 421.02 6.657 0 simundump kreac /kinetics/chain/kinetics[8]/Ras/CaM-GEF/diff 0 0.001 0.001 "" \ white black 422.35 10.58 0 simundump kpool /kinetics/chain/kinetics[8]/Ca 1 -1e-12 0.095 0.095 7162.6 \ 7162.6 0 0 75396 4 /kinetics/dendgeom red black 401 -13 0 simundump kpool /kinetics/chain/kinetics[8]/DAG 1 -1e-12 12.2 12.2 9.1983e+05 \ 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 416.72 -19.562 0 simundump kpool /kinetics/chain/kinetics[8]/PKC-active 1 -1e-12 0.3 \ 2.1196e-16 1.5981e-11 22619 0 0 75396 2 /kinetics/dendgeom red black 416 -3 \ 0 simundump kenz /kinetics/chain/kinetics[8]/PKC-active/PKC-act-raf 1 0 0 0 0 \ 75396 3.979e-06 16 4 0 0 "" red yellow "" 422 -2 0 simundump kenz /kinetics/chain/kinetics[8]/PKC-active/PKC-inact-GAP 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 420 1 0 simundump kenz /kinetics/chain/kinetics[8]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 425 8 0 simundump kenz /kinetics/chain/kinetics[8]/PKC-active/phosph-AC2 1 0 0 0 0 \ 75396 0.00066667 16 4 0 0 "" red red "" 409.32 -23.269 0 simundump kpool /kinetics/chain/kinetics[8]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 429 -11 0 simundump kenz /kinetics/chain/kinetics[8]/MAPK*/MAPK* 0 0 0 0 0 75396 \ 2.5864e-05 40 10 0 0 "" red orange "" 404 -26 0 simundump kenz /kinetics/chain/kinetics[8]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange "" 426 -2 0 simundump kreac /kinetics/chain/kinetics[8]/MAPK*/diff 0 0.001 0.001 "" white \ black 430 -8 0 simundump kpool /kinetics/chain/kinetics[8]/IP3 1 -1e-12 0.73 0.73 55039 \ 55039 0 0 75396 4 /kinetics/dendgeom pink black 415.23 -16.656 0 simundump kpool /kinetics/chain/kinetics[8]/MKP-1 1 -1e-12 0.024 0.024 1809.5 \ 1809.5 0 0 75396 0 /kinetics/dendgeom hotpink black 421 -10 0 simundump kenz /kinetics/chain/kinetics[8]/MKP-1/MKP1-tyr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 422 -9 0 simundump kenz /kinetics/chain/kinetics[8]/MKP-1/MKP1-thr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 427 -9 0 simundump kreac /kinetics/chain/kinetics[8]/MKP-1/diff 0 0.001 0.001 "" white \ black 422 -7 0 simundump kpool /kinetics/chain/kinetics[8]/PPhosphatase2A 1 -1e-12 1 1 75396 \ 75396 0 0 75396 0 /kinetics/dendgeom hotpink yellow 425 -3 0 simundump kenz /kinetics/chain/kinetics[8]/PPhosphatase2A/craf-deph 1 0 0 0 0 \ 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 424 -2 0 simundump kenz /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 427 -5 0 simundump kenz /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph-ser 1 0 \ 0 0 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 424 -5 0 simundump kenz /kinetics/chain/kinetics[8]/PPhosphatase2A/craf**-deph 1 0 0 0 \ 0 0.12566 2.5414e-05 24 6 0 0 "" red hotpink "" 428 -2 0 simundump kreac /kinetics/chain/kinetics[8]/PPhosphatase2A/diff 0 0.001 0.001 \ "" white black 426 0 0 simundump group /kinetics/chain/kinetics[8]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 403 -9 0 simundump kpool /kinetics/chain/kinetics[8]/CaM/CaM 1 -1e-12 20 20 1.5079e+06 \ 1.5079e+06 0 0 75396 0 /kinetics/dendgeom pink blue 402.98 -1.28 0 simundump kreac /kinetics/chain/kinetics[8]/CaM/CaM/diff 0 0.001 0.001 "" \ white black 403.98 1.72 0 simundump kreac /kinetics/chain/kinetics[8]/CaM/CaM-TR2-bind-Ca 1 1.2666e-08 \ 72 "" white blue 405.16 -1.921 0 simundump kreac /kinetics/chain/kinetics[8]/CaM/CaM-TR2-Ca2-bind-Ca 1 \ 4.7748e-05 10 "" white blue 404.16 -3.7747 0 simundump kreac /kinetics/chain/kinetics[8]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 402.6 -6.7404 0 simundump kpool /kinetics/chain/kinetics[8]/CaM/CaM-Ca3 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 406.49 -5.603 0 simundump kreac /kinetics/chain/kinetics[8]/CaM/CaM-Ca3/diff 0 0.001 0.001 "" \ white black 407.49 -2.603 0 simundump kpool /kinetics/chain/kinetics[8]/CaM/CaM-TR2-Ca2 1 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 408 -2.7423 0 simundump kreac /kinetics/chain/kinetics[8]/CaM/CaM-TR2-Ca2/diff 0 0.001 \ 0.001 "" white black 409 0.2577 0 simundump kpool /kinetics/chain/kinetics[8]/CaM/CaM-Ca4 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom blue blue 408 -8 0 simundump kreac /kinetics/chain/kinetics[8]/CaM/CaM-Ca4/diff 0 0.001 0.001 "" \ white black 409 -5 0 simundump kreac /kinetics/chain/kinetics[8]/Ras-act-unphosph-raf 0 7.958e-05 \ 1 "" white black 420 -4 0 simundump kpool /kinetics/chain/kinetics[8]/Ca_input 0 -1e-12 0.08 0.08 \ 6031.7 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 394 -7 0 simundump kreac /kinetics/chain/kinetics[8]/Ca_diff 0 2 2 "" white black 395 \ -12 0 simundump group /kinetics/chain/kinetics[9] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 454 0 0 simundump group /kinetics/chain/kinetics[9]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 462.95 -3.7837 0 simundump kpool /kinetics/chain/kinetics[9]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 461.92 -10.489 0 simundump kreac /kinetics/chain/kinetics[9]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 462.92 -7.489 0 simundump kreac /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca 0 7.958e-06 0.5 \ "" white blue 461.92 -12.123 0 simundump kreac /kinetics/chain/kinetics[9]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 463.94 -11.306 0 simundump kreac /kinetics/chain/kinetics[9]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 462.2 -7.7467 0 simundump kreac /kinetics/chain/kinetics[9]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 463.38 -9.2638 0 simundump kreac /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca-AA 0 1.5916e-08 \ 0.1 "" white blue 465.21 -8.1843 0 simundump kreac /kinetics/chain/kinetics[9]/PKC/PKC-act-by-DAG-AA 0 2 0.2 "" \ white blue 467.25 -8.7678 0 simundump kpool /kinetics/chain/kinetics[9]/PKC/PKC-DAG-AA* 0 -1e-12 \ 4.9137e-18 4.9137e-18 3.7047e-13 3.7047e-13 0 0 75396 0 /kinetics/dendgeom \ cyan blue 466.6 -6.463 0 simundump kreac /kinetics/chain/kinetics[9]/PKC/PKC-DAG-AA*/diff 0 0.001 \ 0.001 "" white black 467.6 -3.463 0 simundump kpool /kinetics/chain/kinetics[9]/PKC/PKC-Ca-AA* 0 -1e-12 \ 1.7501e-16 1.7501e-16 1.3195e-11 1.3195e-11 0 0 75396 0 /kinetics/dendgeom \ orange blue 465.4 -5.7044 0 simundump kreac /kinetics/chain/kinetics[9]/PKC/PKC-Ca-AA*/diff 0 0.001 0.001 \ "" white black 466.4 -2.7044 0 simundump kpool /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb* 0 -1e-12 \ 1.3896e-17 1.3896e-17 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom \ pink blue 463.22 -5.471 0 simundump kreac /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb*/diff 0 0.001 \ 0.001 "" white black 464.22 -2.471 0 simundump kpool /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb* 0 -1e-12 \ 9.4351e-21 9.4351e-21 7.1137e-16 7.1137e-16 0 0 75396 0 /kinetics/dendgeom \ yellow blue 464.17 -6.4922 0 simundump kreac /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb*/diff 0 0.001 \ 0.001 "" white black 465.17 -3.4922 0 simundump kpool /kinetics/chain/kinetics[9]/PKC/PKC-basal* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom pink blue 461.25 -6.4338 0 simundump kreac /kinetics/chain/kinetics[9]/PKC/PKC-basal*/diff 0 0.001 0.001 \ "" white black 462.25 -3.4338 0 simundump kreac /kinetics/chain/kinetics[9]/PKC/PKC-basal-act 0 1 50 "" white \ blue 461.02 -8.9429 0 simundump kpool /kinetics/chain/kinetics[9]/PKC/PKC-AA* 0 -1e-12 1.8134e-17 \ 1.8134e-17 1.3672e-12 1.3672e-12 0 0 75396 0 /kinetics/dendgeom cyan blue \ 467.78 -5.1793 0 simundump kreac /kinetics/chain/kinetics[9]/PKC/PKC-AA*/diff 0 0.001 0.001 "" \ white black 468.78 -2.1793 0 simundump kreac /kinetics/chain/kinetics[9]/PKC/PKC-act-by-AA 0 1.5916e-09 \ 0.1 "" white blue 461.01 -13.865 0 simundump kpool /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG 0 -1e-12 \ 8.4632e-23 8.4632e-23 6.3809e-18 6.3809e-18 0 0 75396 0 /kinetics/dendgeom \ white blue 466.23 -10.197 0 simundump kreac /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG/diff 0 0.001 0.001 \ "" white black 467.23 -7.197 0 simundump kreac /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 462.99 -13.99 0 simundump kpool /kinetics/chain/kinetics[9]/PKC/PKC-DAG 0 -1e-12 1.161e-16 \ 1.161e-16 8.7535e-12 8.7535e-12 0 0 75396 0 /kinetics/dendgeom white blue \ 465 -13.086 0 simundump kreac /kinetics/chain/kinetics[9]/PKC/PKC-DAG/diff 0 0.001 0.001 "" \ white black 466 -10.086 0 simundump kreac /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG-AA 0 2.3874e-07 2 \ "" white blue 464.77 -14.953 0 simundump kpool /kinetics/chain/kinetics[9]/PKC/PKC-DAG-AA 0 -1e-12 \ 2.5188e-19 2.5188e-19 1.8991e-14 1.8991e-14 0 0 75396 0 /kinetics/dendgeom \ white blue 466.62 -11.773 0 simundump kreac /kinetics/chain/kinetics[9]/PKC/PKC-DAG-AA/diff 0 0.001 0.001 \ "" white black 467.62 -8.773 0 simundump kpool /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic 0 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom white blue 459.87 -11.403 0 simundump kreac /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic/diff 0 0.001 \ 0.001 "" white black 460.87 -8.403 0 simundump kpool /kinetics/chain/kinetics[9]/AA 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom darkgreen black 462.71 -21.338 0 simundump kreac /kinetics/chain/kinetics[9]/AA/diff 0 0.001 0.001 "" white \ black 463.71 -18.338 0 simundump group /kinetics/chain/kinetics[9]/PLA2 0 darkgreen black x 0 1 "" \ defaultfile defaultfile.g 0 0 0 458.64 -26.209 0 simundump kpool /kinetics/chain/kinetics[9]/PLA2/PLA2-cytosolic 0 -1e-12 \ 0.39999 0.39999 30158 30158 0 0 75396 0 /kinetics/dendgeom yellow darkgreen \ 454.18 -20.942 0 simundump kreac /kinetics/chain/kinetics[9]/PLA2/PLA2-cytosolic/diff 0 0.001 \ 0.001 "" white black 455.18 -17.942 0 simundump kreac /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca-act 0 1.3263e-05 0.1 \ "" white darkgreen 454.9 -23.104 0 simundump kpool /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom yellow darkgreen 457.28 -23.646 0 simundump kenz /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca*/kenz 0 0 0 0 0 75396 \ 1.7906e-05 21.6 5.4 0 0 "" red yellow "" 459.94 -23.667 0 simundump kreac /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca*/diff 0 0.001 0.001 \ "" white black 458.28 -20.646 0 simundump kreac /kinetics/chain/kinetics[9]/PLA2/PIP2-PLA2-act 0 1.5916e-08 \ 0.5 "" white darkgreen 454.95 -18.75 0 simundump kpool /kinetics/chain/kinetics[9]/PLA2/PIP2-PLA2* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 457.32 -18.292 0 simundump kenz /kinetics/chain/kinetics[9]/PLA2/PIP2-PLA2*/kenz 0 0 0 0 0 \ 75396 3.6607e-05 44.16 11.04 0 0 "" red cyan "" 459.97 -18.271 0 simundump kreac /kinetics/chain/kinetics[9]/PLA2/PIP2-PLA2*/diff 0 0.001 \ 0.001 "" white black 458.32 -15.292 0 simundump kreac /kinetics/chain/kinetics[9]/PLA2/PIP2-Ca-PLA2-act 0 \ 1.5916e-07 0.1 "" white darkgreen 455.9 -19.5 0 simundump kpool /kinetics/chain/kinetics[9]/PLA2/PIP2-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 457.67 -19.896 0 simundump kenz /kinetics/chain/kinetics[9]/PLA2/PIP2-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00011937 144 36 0 0 "" red cyan "" 460.03 -19.979 0 simundump kreac /kinetics/chain/kinetics[9]/PLA2/PIP2-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 458.67 -16.896 0 simundump kreac /kinetics/chain/kinetics[9]/PLA2/DAG-Ca-PLA2-act 0 3.979e-08 \ 4 "" white darkgreen 455.17 -21.834 0 simundump kpool /kinetics/chain/kinetics[9]/PLA2/DAG-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom pink darkgreen 457.86 -22.479 0 simundump kenz /kinetics/chain/kinetics[9]/PLA2/DAG-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00019895 240 60 0 0 "" red pink "" 460.05 -22.354 0 simundump kreac /kinetics/chain/kinetics[9]/PLA2/DAG-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 458.86 -19.479 0 simundump kpool /kinetics/chain/kinetics[9]/PLA2/APC 0 -1e-12 30 30 \ 2.2619e+06 2.2619e+06 0 0 75396 4 /kinetics/dendgeom yellow darkgreen \ 457.76 -21.963 0 simundump kreac /kinetics/chain/kinetics[9]/PLA2/Degrade-AA 1 0.4 0 "" white \ darkgreen 459.82 -17.288 0 simundump kpool /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange darkgreen 458.19 -24.687 0 simundump kenz /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca/kenz 0 0 0 0 0 75396 \ 0.0003979 480 120 0 0 "" red orange "" 459.92 -24.817 0 simundump kreac /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca/diff 0 0.001 0.001 \ "" white black 459.19 -21.687 0 simundump kpool /kinetics/chain/kinetics[9]/PLA2/PLA2* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange darkgreen 456.98 -26.851 0 simundump kreac /kinetics/chain/kinetics[9]/PLA2/PLA2*/diff 0 0.001 0.001 "" \ white black 457.98 -23.851 0 simundump kreac /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca-act 1 7.958e-05 0.1 \ "" white darkgreen 455.91 -24.752 0 simundump kreac /kinetics/chain/kinetics[9]/PLA2/dephosphorylate-PLA2* 1 0.17 \ 0 "" white darkgreen 452.31 -23.735 0 simundump kpool /kinetics/chain/kinetics[9]/temp-PIP2 1 -1e-12 2.5 2.5 \ 1.8849e+05 1.8849e+05 0 0 75396 4 /kinetics/dendgeom green black 450.2 \ -19.047 0 simundump group /kinetics/chain/kinetics[9]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 481 -1 0 simundump kpool /kinetics/chain/kinetics[9]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 472 -4 0 simundump kpool /kinetics/chain/kinetics[9]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 475 -4 0 simundump kpool /kinetics/chain/kinetics[9]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 472 -8 0 simundump kpool /kinetics/chain/kinetics[9]/MAPK/MAPK 0 -1e-12 3.5999 3.5999 \ 2.7142e+05 2.7142e+05 0 0 75396 0 /kinetics/dendgeom pink brown 472 -11 0 simundump kreac /kinetics/chain/kinetics[9]/MAPK/MAPK/diff 0 0.001 0.001 "" \ white black 473 -8 0 simundump kpool /kinetics/chain/kinetics[9]/MAPK/craf-1** 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink brown 478 -4 0 simundump kpool /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr 1 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange brown 475 -11 0 simundump kreac /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr/diff 0 0.001 0.001 \ "" white black 476 -8 0 simundump kpool /kinetics/chain/kinetics[9]/MAPK/MAPKK* 0 0 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom pink brown 479 -8 0 simundump kenz /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 474 -9 0 simundump kenz /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 479 -9 0 simundump kpool /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 475 -8 0 simundump kpool /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 471 -6 0 simundump kenz /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 0 \ 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 474 -6 0 simundump kenz /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 0 \ 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 477 -6 0 simundump kpool /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red brown 471 -7 0 simundump kenz /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 474 -7 0 simundump kenz /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 477 -7 0 simundump kreac /kinetics/chain/kinetics[9]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 469 -3 0 simundump group /kinetics/chain/kinetics[9]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 480.51 4.351 0 simundump kreac /kinetics/chain/kinetics[9]/Ras/dephosph-GEF 1 1 0 "" white \ blue 475.07 5.881 0 simundump kpool /kinetics/chain/kinetics[9]/Ras/inact-GEF 1 -1e-12 0.1 0.1 \ 7539.6 7539.6 0 0 75396 0 /kinetics/dendgeom hotpink blue 478.45 6.352 0 simundump kenz /kinetics/chain/kinetics[9]/Ras/inact-GEF/basal_GEF_activity 0 \ 0 0 0 0 75396 1.313e-07 0.08 0.02 0 0 "" red hotpink "" 477 5 0 simundump kreac /kinetics/chain/kinetics[9]/Ras/inact-GEF/diff 0 0.001 0.001 \ "" white black 479.45 9.352 0 simundump kpool /kinetics/chain/kinetics[9]/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 472.45 5.246 0 simundump kenz /kinetics/chain/kinetics[9]/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 \ 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 473.08 4.086 0 simundump kreac /kinetics/chain/kinetics[9]/Ras/GEF*/diff 0 0.001 0.001 "" \ white black 473.45 8.246 0 simundump kpool /kinetics/chain/kinetics[9]/Ras/GTP-Ras 1 0 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange blue 478.56 1.084 0 simundump kpool /kinetics/chain/kinetics[9]/Ras/GDP-Ras 1 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink blue 472.13 2.165 0 simundump kreac /kinetics/chain/kinetics[9]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 475.1 1.5 0 simundump kreac /kinetics/chain/kinetics[9]/Ras/dephosph-GAP 1 0.1 0 "" white \ blue 470.02 3.524 0 simundump kpool /kinetics/chain/kinetics[9]/Ras/GAP* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red blue 467.35 2.349 0 simundump kreac /kinetics/chain/kinetics[9]/Ras/GAP*/diff 0 0.001 0.001 "" \ white black 468.35 5.349 0 simundump kpool /kinetics/chain/kinetics[9]/Ras/GAP 1 -1e-12 0.01 0.01 753.96 \ 753.96 0 0 75396 0 /kinetics/dendgeom red blue 472.65 0.338 0 simundump kenz /kinetics/chain/kinetics[9]/Ras/GAP/GAP-inact-ras 1 0 0 0 0 \ 75396 0.00065634 40 10 0 0 "" red red "" 475.01 0.403 0 simundump kreac /kinetics/chain/kinetics[9]/Ras/GAP/diff 0 0.001 0.001 "" \ white black 473.65 3.338 0 simundump kreac /kinetics/chain/kinetics[9]/Ras/CaM-bind-GEF 1 0.0026526 1 "" \ white blue 468.49 9.679 0 simundump kpool /kinetics/chain/kinetics[9]/Ras/CaM-GEF 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 471.35 7.58 0 simundump kenz /kinetics/chain/kinetics[9]/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 \ 0 0 75396 1.3131e-05 0.4 0.1 0 0 "" red pink "" 471.02 6.657 0 simundump kreac /kinetics/chain/kinetics[9]/Ras/CaM-GEF/diff 0 0.001 0.001 "" \ white black 472.35 10.58 0 simundump kpool /kinetics/chain/kinetics[9]/Ca 1 -1e-12 0.095 0.095 7162.6 \ 7162.6 0 0 75396 4 /kinetics/dendgeom red black 451 -13 0 simundump kpool /kinetics/chain/kinetics[9]/DAG 1 -1e-12 12.2 12.2 9.1983e+05 \ 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 466.72 -19.562 0 simundump kpool /kinetics/chain/kinetics[9]/PKC-active 1 -1e-12 0.3 \ 2.1196e-16 1.5981e-11 22619 0 0 75396 2 /kinetics/dendgeom red black 466 -3 \ 0 simundump kenz /kinetics/chain/kinetics[9]/PKC-active/PKC-act-raf 1 0 0 0 0 \ 75396 3.979e-06 16 4 0 0 "" red yellow "" 472 -2 0 simundump kenz /kinetics/chain/kinetics[9]/PKC-active/PKC-inact-GAP 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 470 1 0 simundump kenz /kinetics/chain/kinetics[9]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 475 8 0 simundump kenz /kinetics/chain/kinetics[9]/PKC-active/phosph-AC2 1 0 0 0 0 \ 75396 0.00066667 16 4 0 0 "" red red "" 459.32 -23.269 0 simundump kpool /kinetics/chain/kinetics[9]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 479 -11 0 simundump kenz /kinetics/chain/kinetics[9]/MAPK*/MAPK* 0 0 0 0 0 75396 \ 2.5864e-05 40 10 0 0 "" red orange "" 454 -26 0 simundump kenz /kinetics/chain/kinetics[9]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange "" 476 -2 0 simundump kreac /kinetics/chain/kinetics[9]/MAPK*/diff 0 0.001 0.001 "" white \ black 480 -8 0 simundump kpool /kinetics/chain/kinetics[9]/IP3 1 -1e-12 0.73 0.73 55039 \ 55039 0 0 75396 4 /kinetics/dendgeom pink black 465.23 -16.656 0 simundump kpool /kinetics/chain/kinetics[9]/MKP-1 1 -1e-12 0.024 0.024 1809.5 \ 1809.5 0 0 75396 0 /kinetics/dendgeom hotpink black 471 -10 0 simundump kenz /kinetics/chain/kinetics[9]/MKP-1/MKP1-tyr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 472 -9 0 simundump kenz /kinetics/chain/kinetics[9]/MKP-1/MKP1-thr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 477 -9 0 simundump kreac /kinetics/chain/kinetics[9]/MKP-1/diff 0 0.001 0.001 "" white \ black 472 -7 0 simundump kpool /kinetics/chain/kinetics[9]/PPhosphatase2A 1 -1e-12 1 1 75396 \ 75396 0 0 75396 0 /kinetics/dendgeom hotpink yellow 475 -3 0 simundump kenz /kinetics/chain/kinetics[9]/PPhosphatase2A/craf-deph 1 0 0 0 0 \ 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 474 -2 0 simundump kenz /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 477 -5 0 simundump kenz /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph-ser 1 0 \ 0 0 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 474 -5 0 simundump kenz /kinetics/chain/kinetics[9]/PPhosphatase2A/craf**-deph 1 0 0 0 \ 0 0.12566 2.5414e-05 24 6 0 0 "" red hotpink "" 478 -2 0 simundump kreac /kinetics/chain/kinetics[9]/PPhosphatase2A/diff 0 0.001 0.001 \ "" white black 476 0 0 simundump group /kinetics/chain/kinetics[9]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 453 -9 0 simundump kpool /kinetics/chain/kinetics[9]/CaM/CaM 1 -1e-12 20 20 1.5079e+06 \ 1.5079e+06 0 0 75396 0 /kinetics/dendgeom pink blue 452.98 -1.28 0 simundump kreac /kinetics/chain/kinetics[9]/CaM/CaM/diff 0 0.001 0.001 "" \ white black 453.98 1.72 0 simundump kreac /kinetics/chain/kinetics[9]/CaM/CaM-TR2-bind-Ca 1 1.2666e-08 \ 72 "" white blue 455.16 -1.921 0 simundump kreac /kinetics/chain/kinetics[9]/CaM/CaM-TR2-Ca2-bind-Ca 1 \ 4.7748e-05 10 "" white blue 454.16 -3.7747 0 simundump kreac /kinetics/chain/kinetics[9]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 452.6 -6.7404 0 simundump kpool /kinetics/chain/kinetics[9]/CaM/CaM-Ca3 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 456.49 -5.603 0 simundump kreac /kinetics/chain/kinetics[9]/CaM/CaM-Ca3/diff 0 0.001 0.001 "" \ white black 457.49 -2.603 0 simundump kpool /kinetics/chain/kinetics[9]/CaM/CaM-TR2-Ca2 1 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 458 -2.7423 0 simundump kreac /kinetics/chain/kinetics[9]/CaM/CaM-TR2-Ca2/diff 0 0.001 \ 0.001 "" white black 459 0.2577 0 simundump kpool /kinetics/chain/kinetics[9]/CaM/CaM-Ca4 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom blue blue 458 -8 0 simundump kreac /kinetics/chain/kinetics[9]/CaM/CaM-Ca4/diff 0 0.001 0.001 "" \ white black 459 -5 0 simundump kreac /kinetics/chain/kinetics[9]/Ras-act-unphosph-raf 0 7.958e-05 \ 1 "" white black 470 -4 0 simundump kpool /kinetics/chain/kinetics[9]/Ca_input 0 -1e-12 0.08 0.08 \ 6031.7 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 444 -7 0 simundump kreac /kinetics/chain/kinetics[9]/Ca_diff 0 2 2 "" white black 445 \ -12 0 simundump group /kinetics/chain/kinetics[10] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 504 0 0 simundump group /kinetics/chain/kinetics[10]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 512.95 -3.7837 0 simundump kpool /kinetics/chain/kinetics[10]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 511.92 -10.489 0 simundump kreac /kinetics/chain/kinetics[10]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 512.92 -7.489 0 simundump kreac /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 511.92 -12.123 0 simundump kreac /kinetics/chain/kinetics[10]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 513.94 -11.306 0 simundump kreac /kinetics/chain/kinetics[10]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 512.2 -7.7467 0 simundump kreac /kinetics/chain/kinetics[10]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 513.38 -9.2638 0 simundump kreac /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca-AA 0 \ 1.5916e-08 0.1 "" white blue 515.21 -8.1843 0 simundump kreac /kinetics/chain/kinetics[10]/PKC/PKC-act-by-DAG-AA 0 2 0.2 "" \ white blue 517.25 -8.7678 0 simundump kpool /kinetics/chain/kinetics[10]/PKC/PKC-DAG-AA* 0 -1e-12 \ 4.9137e-18 4.9137e-18 3.7047e-13 3.7047e-13 0 0 75396 0 /kinetics/dendgeom \ cyan blue 516.6 -6.463 0 simundump kreac /kinetics/chain/kinetics[10]/PKC/PKC-DAG-AA*/diff 0 0.001 \ 0.001 "" white black 517.6 -3.463 0 simundump kpool /kinetics/chain/kinetics[10]/PKC/PKC-Ca-AA* 0 -1e-12 \ 1.7501e-16 1.7501e-16 1.3195e-11 1.3195e-11 0 0 75396 0 /kinetics/dendgeom \ orange blue 515.4 -5.7044 0 simundump kreac /kinetics/chain/kinetics[10]/PKC/PKC-Ca-AA*/diff 0 0.001 \ 0.001 "" white black 516.4 -2.7044 0 simundump kpool /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb* 0 -1e-12 \ 1.3896e-17 1.3896e-17 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom \ pink blue 513.22 -5.471 0 simundump kreac /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb*/diff 0 0.001 \ 0.001 "" white black 514.22 -2.471 0 simundump kpool /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb* 0 -1e-12 \ 9.4351e-21 9.4351e-21 7.1137e-16 7.1137e-16 0 0 75396 0 /kinetics/dendgeom \ yellow blue 514.17 -6.4922 0 simundump kreac /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb*/diff 0 0.001 \ 0.001 "" white black 515.17 -3.4922 0 simundump kpool /kinetics/chain/kinetics[10]/PKC/PKC-basal* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 511.25 -6.4338 0 simundump kreac /kinetics/chain/kinetics[10]/PKC/PKC-basal*/diff 0 0.001 \ 0.001 "" white black 512.25 -3.4338 0 simundump kreac /kinetics/chain/kinetics[10]/PKC/PKC-basal-act 0 1 50 "" \ white blue 511.02 -8.9429 0 simundump kpool /kinetics/chain/kinetics[10]/PKC/PKC-AA* 0 -1e-12 1.8134e-17 \ 1.8134e-17 1.3672e-12 1.3672e-12 0 0 75396 0 /kinetics/dendgeom cyan blue \ 517.78 -5.1793 0 simundump kreac /kinetics/chain/kinetics[10]/PKC/PKC-AA*/diff 0 0.001 0.001 \ "" white black 518.78 -2.1793 0 simundump kreac /kinetics/chain/kinetics[10]/PKC/PKC-act-by-AA 0 1.5916e-09 \ 0.1 "" white blue 511.01 -13.865 0 simundump kpool /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG 0 -1e-12 \ 8.4632e-23 8.4632e-23 6.3809e-18 6.3809e-18 0 0 75396 0 /kinetics/dendgeom \ white blue 516.23 -10.197 0 simundump kreac /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG/diff 0 0.001 \ 0.001 "" white black 517.23 -7.197 0 simundump kreac /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 512.99 -13.99 0 simundump kpool /kinetics/chain/kinetics[10]/PKC/PKC-DAG 0 -1e-12 1.161e-16 \ 1.161e-16 8.7535e-12 8.7535e-12 0 0 75396 0 /kinetics/dendgeom white blue \ 515 -13.086 0 simundump kreac /kinetics/chain/kinetics[10]/PKC/PKC-DAG/diff 0 0.001 0.001 \ "" white black 516 -10.086 0 simundump kreac /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG-AA 0 2.3874e-07 2 \ "" white blue 514.77 -14.953 0 simundump kpool /kinetics/chain/kinetics[10]/PKC/PKC-DAG-AA 0 -1e-12 \ 2.5188e-19 2.5188e-19 1.8991e-14 1.8991e-14 0 0 75396 0 /kinetics/dendgeom \ white blue 516.62 -11.773 0 simundump kreac /kinetics/chain/kinetics[10]/PKC/PKC-DAG-AA/diff 0 0.001 \ 0.001 "" white black 517.62 -8.773 0 simundump kpool /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic 0 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom white blue 509.87 -11.403 0 simundump kreac /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic/diff 0 0.001 \ 0.001 "" white black 510.87 -8.403 0 simundump kpool /kinetics/chain/kinetics[10]/AA 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom darkgreen black 512.71 -21.338 0 simundump kreac /kinetics/chain/kinetics[10]/AA/diff 0 0.001 0.001 "" white \ black 513.71 -18.338 0 simundump group /kinetics/chain/kinetics[10]/PLA2 0 darkgreen black x 0 1 "" \ defaultfile defaultfile.g 0 0 0 508.64 -26.209 0 simundump kpool /kinetics/chain/kinetics[10]/PLA2/PLA2-cytosolic 0 -1e-12 \ 0.39999 0.39999 30158 30158 0 0 75396 0 /kinetics/dendgeom yellow darkgreen \ 504.18 -20.942 0 simundump kreac /kinetics/chain/kinetics[10]/PLA2/PLA2-cytosolic/diff 0 0.001 \ 0.001 "" white black 505.18 -17.942 0 simundump kreac /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca-act 0 1.3263e-05 \ 0.1 "" white darkgreen 504.9 -23.104 0 simundump kpool /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom yellow darkgreen 507.28 -23.646 0 simundump kenz /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca*/kenz 0 0 0 0 0 \ 75396 1.7906e-05 21.6 5.4 0 0 "" red yellow "" 509.94 -23.667 0 simundump kreac /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca*/diff 0 0.001 0.001 \ "" white black 508.28 -20.646 0 simundump kreac /kinetics/chain/kinetics[10]/PLA2/PIP2-PLA2-act 0 1.5916e-08 \ 0.5 "" white darkgreen 504.95 -18.75 0 simundump kpool /kinetics/chain/kinetics[10]/PLA2/PIP2-PLA2* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 507.32 -18.292 0 simundump kenz /kinetics/chain/kinetics[10]/PLA2/PIP2-PLA2*/kenz 0 0 0 0 0 \ 75396 3.6607e-05 44.16 11.04 0 0 "" red cyan "" 509.97 -18.271 0 simundump kreac /kinetics/chain/kinetics[10]/PLA2/PIP2-PLA2*/diff 0 0.001 \ 0.001 "" white black 508.32 -15.292 0 simundump kreac /kinetics/chain/kinetics[10]/PLA2/PIP2-Ca-PLA2-act 0 \ 1.5916e-07 0.1 "" white darkgreen 505.9 -19.5 0 simundump kpool /kinetics/chain/kinetics[10]/PLA2/PIP2-Ca-PLA2* 0 -1e-12 0 0 \ 0 0 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 507.67 -19.896 0 simundump kenz /kinetics/chain/kinetics[10]/PLA2/PIP2-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00011937 144 36 0 0 "" red cyan "" 510.03 -19.979 0 simundump kreac /kinetics/chain/kinetics[10]/PLA2/PIP2-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 508.67 -16.896 0 simundump kreac /kinetics/chain/kinetics[10]/PLA2/DAG-Ca-PLA2-act 0 3.979e-08 \ 4 "" white darkgreen 505.17 -21.834 0 simundump kpool /kinetics/chain/kinetics[10]/PLA2/DAG-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom pink darkgreen 507.86 -22.479 0 simundump kenz /kinetics/chain/kinetics[10]/PLA2/DAG-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00019895 240 60 0 0 "" red pink "" 510.05 -22.354 0 simundump kreac /kinetics/chain/kinetics[10]/PLA2/DAG-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 508.86 -19.479 0 simundump kpool /kinetics/chain/kinetics[10]/PLA2/APC 0 -1e-12 30 30 \ 2.2619e+06 2.2619e+06 0 0 75396 4 /kinetics/dendgeom yellow darkgreen \ 507.76 -21.963 0 simundump kreac /kinetics/chain/kinetics[10]/PLA2/Degrade-AA 1 0.4 0 "" white \ darkgreen 509.82 -17.288 0 simundump kpool /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange darkgreen 508.19 -24.687 0 simundump kenz /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca/kenz 0 0 0 0 0 \ 75396 0.0003979 480 120 0 0 "" red orange "" 509.92 -24.817 0 simundump kreac /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca/diff 0 0.001 0.001 \ "" white black 509.19 -21.687 0 simundump kpool /kinetics/chain/kinetics[10]/PLA2/PLA2* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange darkgreen 506.98 -26.851 0 simundump kreac /kinetics/chain/kinetics[10]/PLA2/PLA2*/diff 0 0.001 0.001 "" \ white black 507.98 -23.851 0 simundump kreac /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca-act 1 7.958e-05 \ 0.1 "" white darkgreen 505.91 -24.752 0 simundump kreac /kinetics/chain/kinetics[10]/PLA2/dephosphorylate-PLA2* 1 \ 0.17 0 "" white darkgreen 502.31 -23.735 0 simundump kpool /kinetics/chain/kinetics[10]/temp-PIP2 1 -1e-12 2.5 2.5 \ 1.8849e+05 1.8849e+05 0 0 75396 4 /kinetics/dendgeom green black 500.2 \ -19.047 0 simundump group /kinetics/chain/kinetics[10]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 531 -1 0 simundump kpool /kinetics/chain/kinetics[10]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 522 -4 0 simundump kpool /kinetics/chain/kinetics[10]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 525 -4 0 simundump kpool /kinetics/chain/kinetics[10]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 522 -8 0 simundump kpool /kinetics/chain/kinetics[10]/MAPK/MAPK 0 -1e-12 3.5999 3.5999 \ 2.7142e+05 2.7142e+05 0 0 75396 0 /kinetics/dendgeom pink brown 522 -11 0 simundump kreac /kinetics/chain/kinetics[10]/MAPK/MAPK/diff 0 0.001 0.001 "" \ white black 523 -8 0 simundump kpool /kinetics/chain/kinetics[10]/MAPK/craf-1** 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink brown 528 -4 0 simundump kpool /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr 1 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange brown 525 -11 0 simundump kreac /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr/diff 0 0.001 0.001 \ "" white black 526 -8 0 simundump kpool /kinetics/chain/kinetics[10]/MAPK/MAPKK* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 529 -8 0 simundump kenz /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 524 -9 0 simundump kenz /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 529 -9 0 simundump kpool /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 525 -8 0 simundump kpool /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 521 -6 0 simundump kenz /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 524 -6 0 simundump kenz /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 527 -6 0 simundump kpool /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom red brown 521 -7 0 simundump kenz /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 524 -7 0 simundump kenz /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 527 -7 0 simundump kreac /kinetics/chain/kinetics[10]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 519 -3 0 simundump group /kinetics/chain/kinetics[10]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 530.51 4.351 0 simundump kreac /kinetics/chain/kinetics[10]/Ras/dephosph-GEF 1 1 0 "" white \ blue 525.07 5.881 0 simundump kpool /kinetics/chain/kinetics[10]/Ras/inact-GEF 1 -1e-12 0.1 0.1 \ 7539.6 7539.6 0 0 75396 0 /kinetics/dendgeom hotpink blue 528.45 6.352 0 simundump kenz /kinetics/chain/kinetics[10]/Ras/inact-GEF/basal_GEF_activity 0 \ 0 0 0 0 75396 1.313e-07 0.08 0.02 0 0 "" red hotpink "" 527 5 0 simundump kreac /kinetics/chain/kinetics[10]/Ras/inact-GEF/diff 0 0.001 0.001 \ "" white black 529.45 9.352 0 simundump kpool /kinetics/chain/kinetics[10]/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 522.45 5.246 0 simundump kenz /kinetics/chain/kinetics[10]/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 \ 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 523.09 4.086 0 simundump kreac /kinetics/chain/kinetics[10]/Ras/GEF*/diff 0 0.001 0.001 "" \ white black 523.45 8.246 0 simundump kpool /kinetics/chain/kinetics[10]/Ras/GTP-Ras 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange blue 528.56 1.084 0 simundump kpool /kinetics/chain/kinetics[10]/Ras/GDP-Ras 1 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink blue 522.13 2.165 0 simundump kreac /kinetics/chain/kinetics[10]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 525.1 1.5 0 simundump kreac /kinetics/chain/kinetics[10]/Ras/dephosph-GAP 1 0.1 0 "" \ white blue 520.02 3.524 0 simundump kpool /kinetics/chain/kinetics[10]/Ras/GAP* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red blue 517.35 2.349 0 simundump kreac /kinetics/chain/kinetics[10]/Ras/GAP*/diff 0 0.001 0.001 "" \ white black 518.35 5.349 0 simundump kpool /kinetics/chain/kinetics[10]/Ras/GAP 1 -1e-12 0.01 0.01 \ 753.96 753.96 0 0 75396 0 /kinetics/dendgeom red blue 522.66 0.338 0 simundump kenz /kinetics/chain/kinetics[10]/Ras/GAP/GAP-inact-ras 1 0 0 0 0 \ 75396 0.00065634 40 10 0 0 "" red red "" 525.01 0.403 0 simundump kreac /kinetics/chain/kinetics[10]/Ras/GAP/diff 0 0.001 0.001 "" \ white black 523.66 3.338 0 simundump kreac /kinetics/chain/kinetics[10]/Ras/CaM-bind-GEF 1 0.0026526 1 \ "" white blue 518.49 9.679 0 simundump kpool /kinetics/chain/kinetics[10]/Ras/CaM-GEF 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 521.34 7.58 0 simundump kenz /kinetics/chain/kinetics[10]/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 \ 0 0 75396 1.3131e-05 0.4 0.1 0 0 "" red pink "" 521.02 6.657 0 simundump kreac /kinetics/chain/kinetics[10]/Ras/CaM-GEF/diff 0 0.001 0.001 \ "" white black 522.34 10.58 0 simundump kpool /kinetics/chain/kinetics[10]/Ca 1 -1e-12 0.095 0.095 7162.6 \ 7162.6 0 0 75396 4 /kinetics/dendgeom red black 501 -13 0 simundump kpool /kinetics/chain/kinetics[10]/DAG 1 -1e-12 12.2 12.2 \ 9.1983e+05 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 516.72 \ -19.562 0 simundump kpool /kinetics/chain/kinetics[10]/PKC-active 1 -1e-12 0.3 \ 2.1196e-16 1.5981e-11 22619 0 0 75396 2 /kinetics/dendgeom red black 516 -3 \ 0 simundump kenz /kinetics/chain/kinetics[10]/PKC-active/PKC-act-raf 1 0 0 0 0 \ 75396 3.979e-06 16 4 0 0 "" red yellow "" 522 -2 0 simundump kenz /kinetics/chain/kinetics[10]/PKC-active/PKC-inact-GAP 1 0 0 0 \ 0 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 520 1 0 simundump kenz /kinetics/chain/kinetics[10]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 525 8 0 simundump kenz /kinetics/chain/kinetics[10]/PKC-active/phosph-AC2 1 0 0 0 0 \ 75396 0.00066667 16 4 0 0 "" red red "" 509.32 -23.269 0 simundump kpool /kinetics/chain/kinetics[10]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 529 -11 0 simundump kenz /kinetics/chain/kinetics[10]/MAPK*/MAPK* 0 0 0 0 0 75396 \ 2.5864e-05 40 10 0 0 "" red orange "" 504 -26 0 simundump kenz /kinetics/chain/kinetics[10]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange "" 526 -2 0 simundump kreac /kinetics/chain/kinetics[10]/MAPK*/diff 0 0.001 0.001 "" \ white black 530 -8 0 simundump kpool /kinetics/chain/kinetics[10]/IP3 1 -1e-12 0.73 0.73 55039 \ 55039 0 0 75396 4 /kinetics/dendgeom pink black 515.23 -16.656 0 simundump kpool /kinetics/chain/kinetics[10]/MKP-1 1 -1e-12 0.024 0.024 \ 1809.5 1809.5 0 0 75396 0 /kinetics/dendgeom hotpink black 521 -10 0 simundump kenz /kinetics/chain/kinetics[10]/MKP-1/MKP1-tyr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 522 -9 0 simundump kenz /kinetics/chain/kinetics[10]/MKP-1/MKP1-thr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 527 -9 0 simundump kreac /kinetics/chain/kinetics[10]/MKP-1/diff 0 0.001 0.001 "" \ white black 522 -7 0 simundump kpool /kinetics/chain/kinetics[10]/PPhosphatase2A 1 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom hotpink yellow 525 -3 0 simundump kenz /kinetics/chain/kinetics[10]/PPhosphatase2A/craf-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 524 -2 0 simundump kenz /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 527 -5 0 simundump kenz /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph-ser 1 0 \ 0 0 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 524 -5 0 simundump kenz /kinetics/chain/kinetics[10]/PPhosphatase2A/craf**-deph 1 0 0 \ 0 0 0.12566 2.5414e-05 24 6 0 0 "" red hotpink "" 528 -2 0 simundump kreac /kinetics/chain/kinetics[10]/PPhosphatase2A/diff 0 0.001 \ 0.001 "" white black 526 0 0 simundump group /kinetics/chain/kinetics[10]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 503 -9 0 simundump kpool /kinetics/chain/kinetics[10]/CaM/CaM 1 -1e-12 20 20 \ 1.5079e+06 1.5079e+06 0 0 75396 0 /kinetics/dendgeom pink blue 502.98 -1.28 \ 0 simundump kreac /kinetics/chain/kinetics[10]/CaM/CaM/diff 0 0.001 0.001 "" \ white black 503.98 1.72 0 simundump kreac /kinetics/chain/kinetics[10]/CaM/CaM-TR2-bind-Ca 1 1.2666e-08 \ 72 "" white blue 505.16 -1.921 0 simundump kreac /kinetics/chain/kinetics[10]/CaM/CaM-TR2-Ca2-bind-Ca 1 \ 4.7748e-05 10 "" white blue 504.16 -3.7747 0 simundump kreac /kinetics/chain/kinetics[10]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 502.6 -6.7404 0 simundump kpool /kinetics/chain/kinetics[10]/CaM/CaM-Ca3 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 506.49 -5.603 0 simundump kreac /kinetics/chain/kinetics[10]/CaM/CaM-Ca3/diff 0 0.001 0.001 \ "" white black 507.49 -2.603 0 simundump kpool /kinetics/chain/kinetics[10]/CaM/CaM-TR2-Ca2 1 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 508 -2.7423 0 simundump kreac /kinetics/chain/kinetics[10]/CaM/CaM-TR2-Ca2/diff 0 0.001 \ 0.001 "" white black 509 0.2577 0 simundump kpool /kinetics/chain/kinetics[10]/CaM/CaM-Ca4 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom blue blue 508 -8 0 simundump kreac /kinetics/chain/kinetics[10]/CaM/CaM-Ca4/diff 0 0.001 0.001 \ "" white black 509 -5 0 simundump kreac /kinetics/chain/kinetics[10]/Ras-act-unphosph-raf 0 7.958e-05 \ 1 "" white black 520 -4 0 simundump kpool /kinetics/chain/kinetics[10]/Ca_input 0 -1e-12 0.08 0.08 \ 6031.7 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 494 -7 0 simundump kreac /kinetics/chain/kinetics[10]/Ca_diff 0 2 2 "" white black 495 \ -12 0 simundump group /kinetics/chain/kinetics[11] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 554 0 0 simundump group /kinetics/chain/kinetics[11]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 562.95 -3.7837 0 simundump kpool /kinetics/chain/kinetics[11]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 561.92 -10.489 0 simundump kreac /kinetics/chain/kinetics[11]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 562.92 -7.489 0 simundump kreac /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 561.92 -12.123 0 simundump kreac /kinetics/chain/kinetics[11]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 563.94 -11.306 0 simundump kreac /kinetics/chain/kinetics[11]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 562.2 -7.7467 0 simundump kreac /kinetics/chain/kinetics[11]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 563.38 -9.2638 0 simundump kreac /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca-AA 0 \ 1.5916e-08 0.1 "" white blue 565.21 -8.1843 0 simundump kreac /kinetics/chain/kinetics[11]/PKC/PKC-act-by-DAG-AA 0 2 0.2 "" \ white blue 567.25 -8.7678 0 simundump kpool /kinetics/chain/kinetics[11]/PKC/PKC-DAG-AA* 0 -1e-12 \ 4.9137e-18 4.9137e-18 3.7047e-13 3.7047e-13 0 0 75396 0 /kinetics/dendgeom \ cyan blue 566.6 -6.463 0 simundump kreac /kinetics/chain/kinetics[11]/PKC/PKC-DAG-AA*/diff 0 0.001 \ 0.001 "" white black 567.6 -3.463 0 simundump kpool /kinetics/chain/kinetics[11]/PKC/PKC-Ca-AA* 0 -1e-12 \ 1.7501e-16 1.7501e-16 1.3195e-11 1.3195e-11 0 0 75396 0 /kinetics/dendgeom \ orange blue 565.4 -5.7044 0 simundump kreac /kinetics/chain/kinetics[11]/PKC/PKC-Ca-AA*/diff 0 0.001 \ 0.001 "" white black 566.4 -2.7044 0 simundump kpool /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb* 0 -1e-12 \ 1.3896e-17 1.3896e-17 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom \ pink blue 563.22 -5.471 0 simundump kreac /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb*/diff 0 0.001 \ 0.001 "" white black 564.22 -2.471 0 simundump kpool /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb* 0 -1e-12 \ 9.4351e-21 9.4351e-21 7.1137e-16 7.1137e-16 0 0 75396 0 /kinetics/dendgeom \ yellow blue 564.17 -6.4922 0 simundump kreac /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb*/diff 0 0.001 \ 0.001 "" white black 565.17 -3.4922 0 simundump kpool /kinetics/chain/kinetics[11]/PKC/PKC-basal* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 561.25 -6.4338 0 simundump kreac /kinetics/chain/kinetics[11]/PKC/PKC-basal*/diff 0 0.001 \ 0.001 "" white black 562.25 -3.4338 0 simundump kreac /kinetics/chain/kinetics[11]/PKC/PKC-basal-act 0 1 50 "" \ white blue 561.02 -8.9429 0 simundump kpool /kinetics/chain/kinetics[11]/PKC/PKC-AA* 0 -1e-12 1.8134e-17 \ 1.8134e-17 1.3672e-12 1.3672e-12 0 0 75396 0 /kinetics/dendgeom cyan blue \ 567.78 -5.1793 0 simundump kreac /kinetics/chain/kinetics[11]/PKC/PKC-AA*/diff 0 0.001 0.001 \ "" white black 568.78 -2.1793 0 simundump kreac /kinetics/chain/kinetics[11]/PKC/PKC-act-by-AA 0 1.5916e-09 \ 0.1 "" white blue 561.01 -13.865 0 simundump kpool /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG 0 -1e-12 \ 8.4632e-23 8.4632e-23 6.3809e-18 6.3809e-18 0 0 75396 0 /kinetics/dendgeom \ white blue 566.23 -10.197 0 simundump kreac /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG/diff 0 0.001 \ 0.001 "" white black 567.23 -7.197 0 simundump kreac /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 562.99 -13.99 0 simundump kpool /kinetics/chain/kinetics[11]/PKC/PKC-DAG 0 -1e-12 1.161e-16 \ 1.161e-16 8.7535e-12 8.7535e-12 0 0 75396 0 /kinetics/dendgeom white blue \ 565 -13.086 0 simundump kreac /kinetics/chain/kinetics[11]/PKC/PKC-DAG/diff 0 0.001 0.001 \ "" white black 566 -10.086 0 simundump kreac /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG-AA 0 2.3874e-07 2 \ "" white blue 564.77 -14.953 0 simundump kpool /kinetics/chain/kinetics[11]/PKC/PKC-DAG-AA 0 -1e-12 \ 2.5188e-19 2.5188e-19 1.8991e-14 1.8991e-14 0 0 75396 0 /kinetics/dendgeom \ white blue 566.62 -11.773 0 simundump kreac /kinetics/chain/kinetics[11]/PKC/PKC-DAG-AA/diff 0 0.001 \ 0.001 "" white black 567.62 -8.773 0 simundump kpool /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic 0 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom white blue 559.87 -11.403 0 simundump kreac /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic/diff 0 0.001 \ 0.001 "" white black 560.87 -8.403 0 simundump kpool /kinetics/chain/kinetics[11]/AA 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom darkgreen black 562.71 -21.338 0 simundump kreac /kinetics/chain/kinetics[11]/AA/diff 0 0.001 0.001 "" white \ black 563.71 -18.338 0 simundump group /kinetics/chain/kinetics[11]/PLA2 0 darkgreen black x 0 1 "" \ defaultfile defaultfile.g 0 0 0 558.64 -26.209 0 simundump kpool /kinetics/chain/kinetics[11]/PLA2/PLA2-cytosolic 0 -1e-12 \ 0.39999 0.39999 30158 30158 0 0 75396 0 /kinetics/dendgeom yellow darkgreen \ 554.18 -20.942 0 simundump kreac /kinetics/chain/kinetics[11]/PLA2/PLA2-cytosolic/diff 0 0.001 \ 0.001 "" white black 555.18 -17.942 0 simundump kreac /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca-act 0 1.3263e-05 \ 0.1 "" white darkgreen 554.9 -23.104 0 simundump kpool /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom yellow darkgreen 557.28 -23.646 0 simundump kenz /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca*/kenz 0 0 0 0 0 \ 75396 1.7906e-05 21.6 5.4 0 0 "" red yellow "" 559.94 -23.667 0 simundump kreac /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca*/diff 0 0.001 0.001 \ "" white black 558.28 -20.646 0 simundump kreac /kinetics/chain/kinetics[11]/PLA2/PIP2-PLA2-act 0 1.5916e-08 \ 0.5 "" white darkgreen 554.95 -18.75 0 simundump kpool /kinetics/chain/kinetics[11]/PLA2/PIP2-PLA2* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 557.32 -18.292 0 simundump kenz /kinetics/chain/kinetics[11]/PLA2/PIP2-PLA2*/kenz 0 0 0 0 0 \ 75396 3.6607e-05 44.16 11.04 0 0 "" red cyan "" 559.97 -18.271 0 simundump kreac /kinetics/chain/kinetics[11]/PLA2/PIP2-PLA2*/diff 0 0.001 \ 0.001 "" white black 558.32 -15.292 0 simundump kreac /kinetics/chain/kinetics[11]/PLA2/PIP2-Ca-PLA2-act 0 \ 1.5916e-07 0.1 "" white darkgreen 555.9 -19.5 0 simundump kpool /kinetics/chain/kinetics[11]/PLA2/PIP2-Ca-PLA2* 0 -1e-12 0 0 \ 0 0 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 557.67 -19.896 0 simundump kenz /kinetics/chain/kinetics[11]/PLA2/PIP2-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00011937 144 36 0 0 "" red cyan "" 560.03 -19.979 0 simundump kreac /kinetics/chain/kinetics[11]/PLA2/PIP2-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 558.67 -16.896 0 simundump kreac /kinetics/chain/kinetics[11]/PLA2/DAG-Ca-PLA2-act 0 3.979e-08 \ 4 "" white darkgreen 555.17 -21.834 0 simundump kpool /kinetics/chain/kinetics[11]/PLA2/DAG-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom pink darkgreen 557.86 -22.479 0 simundump kenz /kinetics/chain/kinetics[11]/PLA2/DAG-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00019895 240 60 0 0 "" red pink "" 560.05 -22.354 0 simundump kreac /kinetics/chain/kinetics[11]/PLA2/DAG-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 558.86 -19.479 0 simundump kpool /kinetics/chain/kinetics[11]/PLA2/APC 0 -1e-12 30 30 \ 2.2619e+06 2.2619e+06 0 0 75396 4 /kinetics/dendgeom yellow darkgreen \ 557.76 -21.963 0 simundump kreac /kinetics/chain/kinetics[11]/PLA2/Degrade-AA 1 0.4 0 "" white \ darkgreen 559.82 -17.288 0 simundump kpool /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange darkgreen 558.19 -24.687 0 simundump kenz /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca/kenz 0 0 0 0 0 \ 75396 0.0003979 480 120 0 0 "" red orange "" 559.92 -24.817 0 simundump kreac /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca/diff 0 0.001 0.001 \ "" white black 559.19 -21.687 0 simundump kpool /kinetics/chain/kinetics[11]/PLA2/PLA2* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange darkgreen 556.97 -26.851 0 simundump kreac /kinetics/chain/kinetics[11]/PLA2/PLA2*/diff 0 0.001 0.001 "" \ white black 557.97 -23.851 0 simundump kreac /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca-act 1 7.958e-05 \ 0.1 "" white darkgreen 555.91 -24.752 0 simundump kreac /kinetics/chain/kinetics[11]/PLA2/dephosphorylate-PLA2* 1 \ 0.17 0 "" white darkgreen 552.31 -23.735 0 simundump kpool /kinetics/chain/kinetics[11]/temp-PIP2 1 -1e-12 2.5 2.5 \ 1.8849e+05 1.8849e+05 0 0 75396 4 /kinetics/dendgeom green black 550.2 \ -19.047 0 simundump group /kinetics/chain/kinetics[11]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 581 -1 0 simundump kpool /kinetics/chain/kinetics[11]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 572 -4 0 simundump kpool /kinetics/chain/kinetics[11]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 575 -4 0 simundump kpool /kinetics/chain/kinetics[11]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 572 -8 0 simundump kpool /kinetics/chain/kinetics[11]/MAPK/MAPK 0 -1e-12 3.5999 3.5999 \ 2.7142e+05 2.7142e+05 0 0 75396 0 /kinetics/dendgeom pink brown 572 -11 0 simundump kreac /kinetics/chain/kinetics[11]/MAPK/MAPK/diff 0 0.001 0.001 "" \ white black 573 -8 0 simundump kpool /kinetics/chain/kinetics[11]/MAPK/craf-1** 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink brown 578 -4 0 simundump kpool /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr 1 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange brown 575 -11 0 simundump kreac /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr/diff 0 0.001 0.001 \ "" white black 576 -8 0 simundump kpool /kinetics/chain/kinetics[11]/MAPK/MAPKK* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 579 -8 0 simundump kenz /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 574 -9 0 simundump kenz /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 579 -9 0 simundump kpool /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 575 -8 0 simundump kpool /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 571 -6 0 simundump kenz /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 574 -6 0 simundump kenz /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 577 -6 0 simundump kpool /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom red brown 571 -7 0 simundump kenz /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 574 -7 0 simundump kenz /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 577 -7 0 simundump kreac /kinetics/chain/kinetics[11]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 569 -3 0 simundump group /kinetics/chain/kinetics[11]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 580.51 4.351 0 simundump kreac /kinetics/chain/kinetics[11]/Ras/dephosph-GEF 1 1 0 "" white \ blue 575.07 5.881 0 simundump kpool /kinetics/chain/kinetics[11]/Ras/inact-GEF 1 -1e-12 0.1 0.1 \ 7539.6 7539.6 0 0 75396 0 /kinetics/dendgeom hotpink blue 578.45 6.352 0 simundump kenz /kinetics/chain/kinetics[11]/Ras/inact-GEF/basal_GEF_activity 0 \ 0 0 0 0 75396 1.313e-07 0.08 0.02 0 0 "" red hotpink "" 577 5 0 simundump kreac /kinetics/chain/kinetics[11]/Ras/inact-GEF/diff 0 0.001 0.001 \ "" white black 579.45 9.352 0 simundump kpool /kinetics/chain/kinetics[11]/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 572.45 5.246 0 simundump kenz /kinetics/chain/kinetics[11]/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 \ 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 573.09 4.086 0 simundump kreac /kinetics/chain/kinetics[11]/Ras/GEF*/diff 0 0.001 0.001 "" \ white black 573.45 8.246 0 simundump kpool /kinetics/chain/kinetics[11]/Ras/GTP-Ras 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange blue 578.56 1.084 0 simundump kpool /kinetics/chain/kinetics[11]/Ras/GDP-Ras 1 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink blue 572.13 2.165 0 simundump kreac /kinetics/chain/kinetics[11]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 575.1 1.5 0 simundump kreac /kinetics/chain/kinetics[11]/Ras/dephosph-GAP 1 0.1 0 "" \ white blue 570.02 3.524 0 simundump kpool /kinetics/chain/kinetics[11]/Ras/GAP* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red blue 567.35 2.349 0 simundump kreac /kinetics/chain/kinetics[11]/Ras/GAP*/diff 0 0.001 0.001 "" \ white black 568.35 5.349 0 simundump kpool /kinetics/chain/kinetics[11]/Ras/GAP 1 -1e-12 0.01 0.01 \ 753.96 753.96 0 0 75396 0 /kinetics/dendgeom red blue 572.66 0.338 0 simundump kenz /kinetics/chain/kinetics[11]/Ras/GAP/GAP-inact-ras 1 0 0 0 0 \ 75396 0.00065634 40 10 0 0 "" red red "" 575.01 0.403 0 simundump kreac /kinetics/chain/kinetics[11]/Ras/GAP/diff 0 0.001 0.001 "" \ white black 573.66 3.338 0 simundump kreac /kinetics/chain/kinetics[11]/Ras/CaM-bind-GEF 1 0.0026526 1 \ "" white blue 568.49 9.679 0 simundump kpool /kinetics/chain/kinetics[11]/Ras/CaM-GEF 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 571.34 7.58 0 simundump kenz /kinetics/chain/kinetics[11]/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 \ 0 0 75396 1.3131e-05 0.4 0.1 0 0 "" red pink "" 571.02 6.657 0 simundump kreac /kinetics/chain/kinetics[11]/Ras/CaM-GEF/diff 0 0.001 0.001 \ "" white black 572.34 10.58 0 simundump kpool /kinetics/chain/kinetics[11]/Ca 1 -1e-12 0.095 0.095 7162.6 \ 7162.6 0 0 75396 4 /kinetics/dendgeom red black 551 -13 0 simundump kpool /kinetics/chain/kinetics[11]/DAG 1 -1e-12 12.2 12.2 \ 9.1983e+05 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 566.72 \ -19.562 0 simundump kpool /kinetics/chain/kinetics[11]/PKC-active 1 -1e-12 0.3 \ 2.1196e-16 1.5981e-11 22619 0 0 75396 2 /kinetics/dendgeom red black 566 -3 \ 0 simundump kenz /kinetics/chain/kinetics[11]/PKC-active/PKC-act-raf 1 0 0 0 0 \ 75396 3.979e-06 16 4 0 0 "" red yellow "" 572 -2 0 simundump kenz /kinetics/chain/kinetics[11]/PKC-active/PKC-inact-GAP 1 0 0 0 \ 0 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 570 1 0 simundump kenz /kinetics/chain/kinetics[11]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 575 8 0 simundump kenz /kinetics/chain/kinetics[11]/PKC-active/phosph-AC2 1 0 0 0 0 \ 75396 0.00066667 16 4 0 0 "" red red "" 559.32 -23.269 0 simundump kpool /kinetics/chain/kinetics[11]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 579 -11 0 simundump kenz /kinetics/chain/kinetics[11]/MAPK*/MAPK* 0 0 0 0 0 75396 \ 2.5864e-05 40 10 0 0 "" red orange "" 554 -26 0 simundump kenz /kinetics/chain/kinetics[11]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange "" 576 -2 0 simundump kreac /kinetics/chain/kinetics[11]/MAPK*/diff 0 0.001 0.001 "" \ white black 580 -8 0 simundump kpool /kinetics/chain/kinetics[11]/IP3 1 -1e-12 0.73 0.73 55039 \ 55039 0 0 75396 4 /kinetics/dendgeom pink black 565.23 -16.656 0 simundump kpool /kinetics/chain/kinetics[11]/MKP-1 1 -1e-12 0.024 0.024 \ 1809.5 1809.5 0 0 75396 0 /kinetics/dendgeom hotpink black 571 -10 0 simundump kenz /kinetics/chain/kinetics[11]/MKP-1/MKP1-tyr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 572 -9 0 simundump kenz /kinetics/chain/kinetics[11]/MKP-1/MKP1-thr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 577 -9 0 simundump kreac /kinetics/chain/kinetics[11]/MKP-1/diff 0 0.001 0.001 "" \ white black 572 -7 0 simundump kpool /kinetics/chain/kinetics[11]/PPhosphatase2A 1 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom hotpink yellow 575 -3 0 simundump kenz /kinetics/chain/kinetics[11]/PPhosphatase2A/craf-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 574 -2 0 simundump kenz /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 577 -5 0 simundump kenz /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph-ser 1 0 \ 0 0 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 574 -5 0 simundump kenz /kinetics/chain/kinetics[11]/PPhosphatase2A/craf**-deph 1 0 0 \ 0 0 0.12566 2.5414e-05 24 6 0 0 "" red hotpink "" 578 -2 0 simundump kreac /kinetics/chain/kinetics[11]/PPhosphatase2A/diff 0 0.001 \ 0.001 "" white black 576 0 0 simundump group /kinetics/chain/kinetics[11]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 553 -9 0 simundump kpool /kinetics/chain/kinetics[11]/CaM/CaM 1 -1e-12 20 20 \ 1.5079e+06 1.5079e+06 0 0 75396 0 /kinetics/dendgeom pink blue 552.98 -1.28 \ 0 simundump kreac /kinetics/chain/kinetics[11]/CaM/CaM/diff 0 0.001 0.001 "" \ white black 553.98 1.72 0 simundump kreac /kinetics/chain/kinetics[11]/CaM/CaM-TR2-bind-Ca 1 1.2666e-08 \ 72 "" white blue 555.16 -1.921 0 simundump kreac /kinetics/chain/kinetics[11]/CaM/CaM-TR2-Ca2-bind-Ca 1 \ 4.7748e-05 10 "" white blue 554.16 -3.7747 0 simundump kreac /kinetics/chain/kinetics[11]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 552.6 -6.7404 0 simundump kpool /kinetics/chain/kinetics[11]/CaM/CaM-Ca3 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 556.49 -5.603 0 simundump kreac /kinetics/chain/kinetics[11]/CaM/CaM-Ca3/diff 0 0.001 0.001 \ "" white black 557.49 -2.603 0 simundump kpool /kinetics/chain/kinetics[11]/CaM/CaM-TR2-Ca2 1 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 558 -2.7423 0 simundump kreac /kinetics/chain/kinetics[11]/CaM/CaM-TR2-Ca2/diff 0 0.001 \ 0.001 "" white black 559 0.2577 0 simundump kpool /kinetics/chain/kinetics[11]/CaM/CaM-Ca4 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom blue blue 558 -8 0 simundump kreac /kinetics/chain/kinetics[11]/CaM/CaM-Ca4/diff 0 0.001 0.001 \ "" white black 559 -5 0 simundump kreac /kinetics/chain/kinetics[11]/Ras-act-unphosph-raf 0 7.958e-05 \ 1 "" white black 570 -4 0 simundump kpool /kinetics/chain/kinetics[11]/Ca_input 0 -1e-12 0.08 0.08 \ 6031.7 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 544 -7 0 simundump kreac /kinetics/chain/kinetics[11]/Ca_diff 0 2 2 "" white black 545 \ -12 0 simundump group /kinetics/chain/kinetics[12] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 604 0 0 simundump group /kinetics/chain/kinetics[12]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 612.95 -3.7837 0 simundump kpool /kinetics/chain/kinetics[12]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 611.92 -10.489 0 simundump kreac /kinetics/chain/kinetics[12]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 612.92 -7.489 0 simundump kreac /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 611.92 -12.123 0 simundump kreac /kinetics/chain/kinetics[12]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 613.94 -11.306 0 simundump kreac /kinetics/chain/kinetics[12]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 612.2 -7.7467 0 simundump kreac /kinetics/chain/kinetics[12]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 613.38 -9.2638 0 simundump kreac /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca-AA 0 \ 1.5916e-08 0.1 "" white blue 615.21 -8.1843 0 simundump kreac /kinetics/chain/kinetics[12]/PKC/PKC-act-by-DAG-AA 0 2 0.2 "" \ white blue 617.25 -8.7678 0 simundump kpool /kinetics/chain/kinetics[12]/PKC/PKC-DAG-AA* 0 -1e-12 \ 4.9137e-18 4.9137e-18 3.7047e-13 3.7047e-13 0 0 75396 0 /kinetics/dendgeom \ cyan blue 616.6 -6.463 0 simundump kreac /kinetics/chain/kinetics[12]/PKC/PKC-DAG-AA*/diff 0 0.001 \ 0.001 "" white black 617.6 -3.463 0 simundump kpool /kinetics/chain/kinetics[12]/PKC/PKC-Ca-AA* 0 -1e-12 \ 1.7501e-16 1.7501e-16 1.3195e-11 1.3195e-11 0 0 75396 0 /kinetics/dendgeom \ orange blue 615.4 -5.7044 0 simundump kreac /kinetics/chain/kinetics[12]/PKC/PKC-Ca-AA*/diff 0 0.001 \ 0.001 "" white black 616.4 -2.7044 0 simundump kpool /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb* 0 -1e-12 \ 1.3896e-17 1.3896e-17 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom \ pink blue 613.22 -5.471 0 simundump kreac /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb*/diff 0 0.001 \ 0.001 "" white black 614.22 -2.471 0 simundump kpool /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb* 0 -1e-12 \ 9.4351e-21 9.4351e-21 7.1137e-16 7.1137e-16 0 0 75396 0 /kinetics/dendgeom \ yellow blue 614.17 -6.4922 0 simundump kreac /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb*/diff 0 0.001 \ 0.001 "" white black 615.17 -3.4922 0 simundump kpool /kinetics/chain/kinetics[12]/PKC/PKC-basal* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 611.25 -6.4338 0 simundump kreac /kinetics/chain/kinetics[12]/PKC/PKC-basal*/diff 0 0.001 \ 0.001 "" white black 612.25 -3.4338 0 simundump kreac /kinetics/chain/kinetics[12]/PKC/PKC-basal-act 0 1 50 "" \ white blue 611.02 -8.9429 0 simundump kpool /kinetics/chain/kinetics[12]/PKC/PKC-AA* 0 -1e-12 1.8134e-17 \ 1.8134e-17 1.3672e-12 1.3672e-12 0 0 75396 0 /kinetics/dendgeom cyan blue \ 617.78 -5.1793 0 simundump kreac /kinetics/chain/kinetics[12]/PKC/PKC-AA*/diff 0 0.001 0.001 \ "" white black 618.78 -2.1793 0 simundump kreac /kinetics/chain/kinetics[12]/PKC/PKC-act-by-AA 0 1.5916e-09 \ 0.1 "" white blue 611.01 -13.865 0 simundump kpool /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG 0 -1e-12 \ 8.4632e-23 8.4632e-23 6.3809e-18 6.3809e-18 0 0 75396 0 /kinetics/dendgeom \ white blue 616.23 -10.197 0 simundump kreac /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG/diff 0 0.001 \ 0.001 "" white black 617.23 -7.197 0 simundump kreac /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 612.99 -13.99 0 simundump kpool /kinetics/chain/kinetics[12]/PKC/PKC-DAG 0 -1e-12 1.161e-16 \ 1.161e-16 8.7535e-12 8.7535e-12 0 0 75396 0 /kinetics/dendgeom white blue \ 615 -13.086 0 simundump kreac /kinetics/chain/kinetics[12]/PKC/PKC-DAG/diff 0 0.001 0.001 \ "" white black 616 -10.086 0 simundump kreac /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG-AA 0 2.3874e-07 2 \ "" white blue 614.77 -14.953 0 simundump kpool /kinetics/chain/kinetics[12]/PKC/PKC-DAG-AA 0 -1e-12 \ 2.5188e-19 2.5188e-19 1.8991e-14 1.8991e-14 0 0 75396 0 /kinetics/dendgeom \ white blue 616.62 -11.773 0 simundump kreac /kinetics/chain/kinetics[12]/PKC/PKC-DAG-AA/diff 0 0.001 \ 0.001 "" white black 617.62 -8.773 0 simundump kpool /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic 0 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom white blue 609.87 -11.403 0 simundump kreac /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic/diff 0 0.001 \ 0.001 "" white black 610.87 -8.403 0 simundump kpool /kinetics/chain/kinetics[12]/AA 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom darkgreen black 612.71 -21.338 0 simundump kreac /kinetics/chain/kinetics[12]/AA/diff 0 0.001 0.001 "" white \ black 613.71 -18.338 0 simundump group /kinetics/chain/kinetics[12]/PLA2 0 darkgreen black x 0 1 "" \ defaultfile defaultfile.g 0 0 0 608.64 -26.209 0 simundump kpool /kinetics/chain/kinetics[12]/PLA2/PLA2-cytosolic 0 -1e-12 \ 0.39999 0.39999 30158 30158 0 0 75396 0 /kinetics/dendgeom yellow darkgreen \ 604.18 -20.942 0 simundump kreac /kinetics/chain/kinetics[12]/PLA2/PLA2-cytosolic/diff 0 0.001 \ 0.001 "" white black 605.18 -17.942 0 simundump kreac /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca-act 0 1.3263e-05 \ 0.1 "" white darkgreen 604.9 -23.104 0 simundump kpool /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom yellow darkgreen 607.28 -23.646 0 simundump kenz /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca*/kenz 0 0 0 0 0 \ 75396 1.7906e-05 21.6 5.4 0 0 "" red yellow "" 609.94 -23.667 0 simundump kreac /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca*/diff 0 0.001 0.001 \ "" white black 608.28 -20.646 0 simundump kreac /kinetics/chain/kinetics[12]/PLA2/PIP2-PLA2-act 0 1.5916e-08 \ 0.5 "" white darkgreen 604.95 -18.75 0 simundump kpool /kinetics/chain/kinetics[12]/PLA2/PIP2-PLA2* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 607.32 -18.292 0 simundump kenz /kinetics/chain/kinetics[12]/PLA2/PIP2-PLA2*/kenz 0 0 0 0 0 \ 75396 3.6607e-05 44.16 11.04 0 0 "" red cyan "" 609.97 -18.271 0 simundump kreac /kinetics/chain/kinetics[12]/PLA2/PIP2-PLA2*/diff 0 0.001 \ 0.001 "" white black 608.32 -15.292 0 simundump kreac /kinetics/chain/kinetics[12]/PLA2/PIP2-Ca-PLA2-act 0 \ 1.5916e-07 0.1 "" white darkgreen 605.9 -19.5 0 simundump kpool /kinetics/chain/kinetics[12]/PLA2/PIP2-Ca-PLA2* 0 -1e-12 0 0 \ 0 0 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 607.67 -19.896 0 simundump kenz /kinetics/chain/kinetics[12]/PLA2/PIP2-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00011937 144 36 0 0 "" red cyan "" 610.03 -19.979 0 simundump kreac /kinetics/chain/kinetics[12]/PLA2/PIP2-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 608.67 -16.896 0 simundump kreac /kinetics/chain/kinetics[12]/PLA2/DAG-Ca-PLA2-act 0 3.979e-08 \ 4 "" white darkgreen 605.17 -21.834 0 simundump kpool /kinetics/chain/kinetics[12]/PLA2/DAG-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom pink darkgreen 607.86 -22.479 0 simundump kenz /kinetics/chain/kinetics[12]/PLA2/DAG-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00019895 240 60 0 0 "" red pink "" 610.05 -22.354 0 simundump kreac /kinetics/chain/kinetics[12]/PLA2/DAG-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 608.86 -19.479 0 simundump kpool /kinetics/chain/kinetics[12]/PLA2/APC 0 -1e-12 30 30 \ 2.2619e+06 2.2619e+06 0 0 75396 4 /kinetics/dendgeom yellow darkgreen \ 607.76 -21.963 0 simundump kreac /kinetics/chain/kinetics[12]/PLA2/Degrade-AA 1 0.4 0 "" white \ darkgreen 609.82 -17.288 0 simundump kpool /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange darkgreen 608.19 -24.687 0 simundump kenz /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca/kenz 0 0 0 0 0 \ 75396 0.0003979 480 120 0 0 "" red orange "" 609.92 -24.817 0 simundump kreac /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca/diff 0 0.001 0.001 \ "" white black 609.19 -21.687 0 simundump kpool /kinetics/chain/kinetics[12]/PLA2/PLA2* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange darkgreen 606.97 -26.851 0 simundump kreac /kinetics/chain/kinetics[12]/PLA2/PLA2*/diff 0 0.001 0.001 "" \ white black 607.97 -23.851 0 simundump kreac /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca-act 1 7.958e-05 \ 0.1 "" white darkgreen 605.91 -24.752 0 simundump kreac /kinetics/chain/kinetics[12]/PLA2/dephosphorylate-PLA2* 1 \ 0.17 0 "" white darkgreen 602.31 -23.735 0 simundump kpool /kinetics/chain/kinetics[12]/temp-PIP2 1 -1e-12 2.5 2.5 \ 1.8849e+05 1.8849e+05 0 0 75396 4 /kinetics/dendgeom green black 600.2 \ -19.047 0 simundump group /kinetics/chain/kinetics[12]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 631 -1 0 simundump kpool /kinetics/chain/kinetics[12]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 622 -4 0 simundump kpool /kinetics/chain/kinetics[12]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 625 -4 0 simundump kpool /kinetics/chain/kinetics[12]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 622 -8 0 simundump kpool /kinetics/chain/kinetics[12]/MAPK/MAPK 0 -1e-12 3.5999 3.5999 \ 2.7142e+05 2.7142e+05 0 0 75396 0 /kinetics/dendgeom pink brown 622 -11 0 simundump kreac /kinetics/chain/kinetics[12]/MAPK/MAPK/diff 0 0.001 0.001 "" \ white black 623 -8 0 simundump kpool /kinetics/chain/kinetics[12]/MAPK/craf-1** 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink brown 628 -4 0 simundump kpool /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr 1 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange brown 625 -11 0 simundump kreac /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr/diff 0 0.001 0.001 \ "" white black 626 -8 0 simundump kpool /kinetics/chain/kinetics[12]/MAPK/MAPKK* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 629 -8 0 simundump kenz /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 624 -9 0 simundump kenz /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 629 -9 0 simundump kpool /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 625 -8 0 simundump kpool /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 621 -6 0 simundump kenz /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 624 -6 0 simundump kenz /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 627 -6 0 simundump kpool /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom red brown 621 -7 0 simundump kenz /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 624 -7 0 simundump kenz /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 627 -7 0 simundump kreac /kinetics/chain/kinetics[12]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 619 -3 0 simundump group /kinetics/chain/kinetics[12]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 630.51 4.351 0 simundump kreac /kinetics/chain/kinetics[12]/Ras/dephosph-GEF 1 1 0 "" white \ blue 625.07 5.881 0 simundump kpool /kinetics/chain/kinetics[12]/Ras/inact-GEF 1 -1e-12 0.1 0.1 \ 7539.6 7539.6 0 0 75396 0 /kinetics/dendgeom hotpink blue 628.45 6.352 0 simundump kenz /kinetics/chain/kinetics[12]/Ras/inact-GEF/basal_GEF_activity 0 \ 0 0 0 0 75396 1.313e-07 0.08 0.02 0 0 "" red hotpink "" 627 5 0 simundump kreac /kinetics/chain/kinetics[12]/Ras/inact-GEF/diff 0 0.001 0.001 \ "" white black 629.45 9.352 0 simundump kpool /kinetics/chain/kinetics[12]/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 622.45 5.246 0 simundump kenz /kinetics/chain/kinetics[12]/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 \ 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 623.09 4.086 0 simundump kreac /kinetics/chain/kinetics[12]/Ras/GEF*/diff 0 0.001 0.001 "" \ white black 623.45 8.246 0 simundump kpool /kinetics/chain/kinetics[12]/Ras/GTP-Ras 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange blue 628.56 1.084 0 simundump kpool /kinetics/chain/kinetics[12]/Ras/GDP-Ras 1 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink blue 622.13 2.165 0 simundump kreac /kinetics/chain/kinetics[12]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 625.1 1.5 0 simundump kreac /kinetics/chain/kinetics[12]/Ras/dephosph-GAP 1 0.1 0 "" \ white blue 620.02 3.524 0 simundump kpool /kinetics/chain/kinetics[12]/Ras/GAP* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red blue 617.35 2.349 0 simundump kreac /kinetics/chain/kinetics[12]/Ras/GAP*/diff 0 0.001 0.001 "" \ white black 618.35 5.349 0 simundump kpool /kinetics/chain/kinetics[12]/Ras/GAP 1 -1e-12 0.01 0.01 \ 753.96 753.96 0 0 75396 0 /kinetics/dendgeom red blue 622.66 0.338 0 simundump kenz /kinetics/chain/kinetics[12]/Ras/GAP/GAP-inact-ras 1 0 0 0 0 \ 75396 0.00065634 40 10 0 0 "" red red "" 625.01 0.403 0 simundump kreac /kinetics/chain/kinetics[12]/Ras/GAP/diff 0 0.001 0.001 "" \ white black 623.66 3.338 0 simundump kreac /kinetics/chain/kinetics[12]/Ras/CaM-bind-GEF 1 0.0026526 1 \ "" white blue 618.49 9.679 0 simundump kpool /kinetics/chain/kinetics[12]/Ras/CaM-GEF 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 621.34 7.58 0 simundump kenz /kinetics/chain/kinetics[12]/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 \ 0 0 75396 1.3131e-05 0.4 0.1 0 0 "" red pink "" 621.02 6.657 0 simundump kreac /kinetics/chain/kinetics[12]/Ras/CaM-GEF/diff 0 0.001 0.001 \ "" white black 622.34 10.58 0 simundump kpool /kinetics/chain/kinetics[12]/Ca 1 -1e-12 0.095 0.095 7162.6 \ 7162.6 0 0 75396 4 /kinetics/dendgeom red black 601 -13 0 simundump kpool /kinetics/chain/kinetics[12]/DAG 1 -1e-12 12.2 12.2 \ 9.1983e+05 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 616.72 \ -19.562 0 simundump kpool /kinetics/chain/kinetics[12]/PKC-active 1 -1e-12 0.3 \ 2.1196e-16 1.5981e-11 22619 0 0 75396 2 /kinetics/dendgeom red black 616 -3 \ 0 simundump kenz /kinetics/chain/kinetics[12]/PKC-active/PKC-act-raf 1 0 0 0 0 \ 75396 3.979e-06 16 4 0 0 "" red yellow "" 622 -2 0 simundump kenz /kinetics/chain/kinetics[12]/PKC-active/PKC-inact-GAP 1 0 0 0 \ 0 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 620 1 0 simundump kenz /kinetics/chain/kinetics[12]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 625 8 0 simundump kenz /kinetics/chain/kinetics[12]/PKC-active/phosph-AC2 1 0 0 0 0 \ 75396 0.00066667 16 4 0 0 "" red red "" 609.32 -23.269 0 simundump kpool /kinetics/chain/kinetics[12]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 629 -11 0 simundump kenz /kinetics/chain/kinetics[12]/MAPK*/MAPK* 0 0 0 0 0 75396 \ 2.5864e-05 40 10 0 0 "" red orange "" 604 -26 0 simundump kenz /kinetics/chain/kinetics[12]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange "" 626 -2 0 simundump kreac /kinetics/chain/kinetics[12]/MAPK*/diff 0 0.001 0.001 "" \ white black 630 -8 0 simundump kpool /kinetics/chain/kinetics[12]/IP3 1 -1e-12 0.73 0.73 55039 \ 55039 0 0 75396 4 /kinetics/dendgeom pink black 615.23 -16.656 0 simundump kpool /kinetics/chain/kinetics[12]/MKP-1 1 -1e-12 0.024 0.024 \ 1809.5 1809.5 0 0 75396 0 /kinetics/dendgeom hotpink black 621 -10 0 simundump kenz /kinetics/chain/kinetics[12]/MKP-1/MKP1-tyr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 622 -9 0 simundump kenz /kinetics/chain/kinetics[12]/MKP-1/MKP1-thr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 627 -9 0 simundump kreac /kinetics/chain/kinetics[12]/MKP-1/diff 0 0.001 0.001 "" \ white black 622 -7 0 simundump kpool /kinetics/chain/kinetics[12]/PPhosphatase2A 1 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom hotpink yellow 625 -3 0 simundump kenz /kinetics/chain/kinetics[12]/PPhosphatase2A/craf-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 624 -2 0 simundump kenz /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 627 -5 0 simundump kenz /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph-ser 1 0 \ 0 0 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 624 -5 0 simundump kenz /kinetics/chain/kinetics[12]/PPhosphatase2A/craf**-deph 1 0 0 \ 0 0 0.12566 2.5414e-05 24 6 0 0 "" red hotpink "" 628 -2 0 simundump kreac /kinetics/chain/kinetics[12]/PPhosphatase2A/diff 0 0.001 \ 0.001 "" white black 626 0 0 simundump group /kinetics/chain/kinetics[12]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 603 -9 0 simundump kpool /kinetics/chain/kinetics[12]/CaM/CaM 1 -1e-12 20 20 \ 1.5079e+06 1.5079e+06 0 0 75396 0 /kinetics/dendgeom pink blue 602.98 -1.28 \ 0 simundump kreac /kinetics/chain/kinetics[12]/CaM/CaM/diff 0 0.001 0.001 "" \ white black 603.98 1.72 0 simundump kreac /kinetics/chain/kinetics[12]/CaM/CaM-TR2-bind-Ca 1 1.2666e-08 \ 72 "" white blue 605.16 -1.921 0 simundump kreac /kinetics/chain/kinetics[12]/CaM/CaM-TR2-Ca2-bind-Ca 1 \ 4.7748e-05 10 "" white blue 604.16 -3.7747 0 simundump kreac /kinetics/chain/kinetics[12]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 602.6 -6.7404 0 simundump kpool /kinetics/chain/kinetics[12]/CaM/CaM-Ca3 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 606.49 -5.603 0 simundump kreac /kinetics/chain/kinetics[12]/CaM/CaM-Ca3/diff 0 0.001 0.001 \ "" white black 607.49 -2.603 0 simundump kpool /kinetics/chain/kinetics[12]/CaM/CaM-TR2-Ca2 1 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 608 -2.7423 0 simundump kreac /kinetics/chain/kinetics[12]/CaM/CaM-TR2-Ca2/diff 0 0.001 \ 0.001 "" white black 609 0.2577 0 simundump kpool /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom blue blue 608 -8 0 simundump kreac /kinetics/chain/kinetics[12]/CaM/CaM-Ca4/diff 0 0.001 0.001 \ "" white black 609 -5 0 simundump kreac /kinetics/chain/kinetics[12]/Ras-act-unphosph-raf 0 7.958e-05 \ 1 "" white black 620 -4 0 simundump kpool /kinetics/chain/kinetics[12]/Ca_input 0 -1e-12 0.08 0.08 \ 6031.7 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 594 -7 0 simundump kreac /kinetics/chain/kinetics[12]/Ca_diff 0 2 2 "" white black 595 \ -12 0 simundump group /kinetics/chain/kinetics[13] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 654 0 0 simundump group /kinetics/chain/kinetics[13]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 662.95 -3.7837 0 simundump kpool /kinetics/chain/kinetics[13]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 661.92 -10.489 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 662.92 -7.489 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 661.92 -12.123 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 663.94 -11.306 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 662.2 -7.7467 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 663.38 -9.2638 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca-AA 0 \ 1.5916e-08 0.1 "" white blue 665.21 -8.1843 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-act-by-DAG-AA 0 2 0.2 "" \ white blue 667.25 -8.7678 0 simundump kpool /kinetics/chain/kinetics[13]/PKC/PKC-DAG-AA* 0 -1e-12 \ 4.9137e-18 4.9137e-18 3.7047e-13 3.7047e-13 0 0 75396 0 /kinetics/dendgeom \ cyan blue 666.6 -6.463 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-DAG-AA*/diff 0 0.001 \ 0.001 "" white black 667.6 -3.463 0 simundump kpool /kinetics/chain/kinetics[13]/PKC/PKC-Ca-AA* 0 -1e-12 \ 1.7501e-16 1.7501e-16 1.3195e-11 1.3195e-11 0 0 75396 0 /kinetics/dendgeom \ orange blue 665.4 -5.7044 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-Ca-AA*/diff 0 0.001 \ 0.001 "" white black 666.4 -2.7044 0 simundump kpool /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb* 0 -1e-12 \ 1.3896e-17 1.3896e-17 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom \ pink blue 663.22 -5.471 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb*/diff 0 0.001 \ 0.001 "" white black 664.22 -2.471 0 simundump kpool /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb* 0 -1e-12 \ 9.4351e-21 9.4351e-21 7.1137e-16 7.1137e-16 0 0 75396 0 /kinetics/dendgeom \ yellow blue 664.17 -6.4922 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb*/diff 0 0.001 \ 0.001 "" white black 665.17 -3.4922 0 simundump kpool /kinetics/chain/kinetics[13]/PKC/PKC-basal* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 661.25 -6.4338 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-basal*/diff 0 0.001 \ 0.001 "" white black 662.25 -3.4338 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-basal-act 0 1 50 "" \ white blue 661.02 -8.9429 0 simundump kpool /kinetics/chain/kinetics[13]/PKC/PKC-AA* 0 -1e-12 1.8134e-17 \ 1.8134e-17 1.3672e-12 1.3672e-12 0 0 75396 0 /kinetics/dendgeom cyan blue \ 667.78 -5.1793 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-AA*/diff 0 0.001 0.001 \ "" white black 668.78 -2.1793 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-act-by-AA 0 1.5916e-09 \ 0.1 "" white blue 661.01 -13.865 0 simundump kpool /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG 0 -1e-12 \ 8.4632e-23 8.4632e-23 6.3809e-18 6.3809e-18 0 0 75396 0 /kinetics/dendgeom \ white blue 666.23 -10.197 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG/diff 0 0.001 \ 0.001 "" white black 667.23 -7.197 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 662.99 -13.99 0 simundump kpool /kinetics/chain/kinetics[13]/PKC/PKC-DAG 0 -1e-12 1.161e-16 \ 1.161e-16 8.7535e-12 8.7535e-12 0 0 75396 0 /kinetics/dendgeom white blue \ 665 -13.086 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-DAG/diff 0 0.001 0.001 \ "" white black 666 -10.086 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG-AA 0 2.3874e-07 2 \ "" white blue 664.77 -14.953 0 simundump kpool /kinetics/chain/kinetics[13]/PKC/PKC-DAG-AA 0 -1e-12 \ 2.5188e-19 2.5188e-19 1.8991e-14 1.8991e-14 0 0 75396 0 /kinetics/dendgeom \ white blue 666.62 -11.773 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-DAG-AA/diff 0 0.001 \ 0.001 "" white black 667.62 -8.773 0 simundump kpool /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic 0 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom white blue 659.87 -11.403 0 simundump kreac /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic/diff 0 0.001 \ 0.001 "" white black 660.87 -8.403 0 simundump kpool /kinetics/chain/kinetics[13]/AA 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom darkgreen black 662.71 -21.338 0 simundump kreac /kinetics/chain/kinetics[13]/AA/diff 0 0.001 0.001 "" white \ black 663.71 -18.338 0 simundump group /kinetics/chain/kinetics[13]/PLA2 0 darkgreen black x 0 1 "" \ defaultfile defaultfile.g 0 0 0 658.64 -26.209 0 simundump kpool /kinetics/chain/kinetics[13]/PLA2/PLA2-cytosolic 0 -1e-12 \ 0.39999 0.39999 30158 30158 0 0 75396 0 /kinetics/dendgeom yellow darkgreen \ 654.18 -20.942 0 simundump kreac /kinetics/chain/kinetics[13]/PLA2/PLA2-cytosolic/diff 0 0.001 \ 0.001 "" white black 655.18 -17.942 0 simundump kreac /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca-act 0 1.3263e-05 \ 0.1 "" white darkgreen 654.9 -23.104 0 simundump kpool /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom yellow darkgreen 657.28 -23.646 0 simundump kenz /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca*/kenz 0 0 0 0 0 \ 75396 1.7906e-05 21.6 5.4 0 0 "" red yellow "" 659.94 -23.667 0 simundump kreac /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca*/diff 0 0.001 0.001 \ "" white black 658.28 -20.646 0 simundump kreac /kinetics/chain/kinetics[13]/PLA2/PIP2-PLA2-act 0 1.5916e-08 \ 0.5 "" white darkgreen 654.95 -18.75 0 simundump kpool /kinetics/chain/kinetics[13]/PLA2/PIP2-PLA2* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 657.32 -18.292 0 simundump kenz /kinetics/chain/kinetics[13]/PLA2/PIP2-PLA2*/kenz 0 0 0 0 0 \ 75396 3.6607e-05 44.16 11.04 0 0 "" red cyan "" 659.97 -18.271 0 simundump kreac /kinetics/chain/kinetics[13]/PLA2/PIP2-PLA2*/diff 0 0.001 \ 0.001 "" white black 658.32 -15.292 0 simundump kreac /kinetics/chain/kinetics[13]/PLA2/PIP2-Ca-PLA2-act 0 \ 1.5916e-07 0.1 "" white darkgreen 655.9 -19.5 0 simundump kpool /kinetics/chain/kinetics[13]/PLA2/PIP2-Ca-PLA2* 0 -1e-12 0 0 \ 0 0 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 657.67 -19.896 0 simundump kenz /kinetics/chain/kinetics[13]/PLA2/PIP2-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00011937 144 36 0 0 "" red cyan "" 660.03 -19.979 0 simundump kreac /kinetics/chain/kinetics[13]/PLA2/PIP2-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 658.67 -16.896 0 simundump kreac /kinetics/chain/kinetics[13]/PLA2/DAG-Ca-PLA2-act 0 3.979e-08 \ 4 "" white darkgreen 655.17 -21.834 0 simundump kpool /kinetics/chain/kinetics[13]/PLA2/DAG-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom pink darkgreen 657.86 -22.479 0 simundump kenz /kinetics/chain/kinetics[13]/PLA2/DAG-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00019895 240 60 0 0 "" red pink "" 660.05 -22.354 0 simundump kreac /kinetics/chain/kinetics[13]/PLA2/DAG-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 658.86 -19.479 0 simundump kpool /kinetics/chain/kinetics[13]/PLA2/APC 0 -1e-12 30 30 \ 2.2619e+06 2.2619e+06 0 0 75396 4 /kinetics/dendgeom yellow darkgreen \ 657.76 -21.963 0 simundump kreac /kinetics/chain/kinetics[13]/PLA2/Degrade-AA 1 0.4 0 "" white \ darkgreen 659.82 -17.288 0 simundump kpool /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange darkgreen 658.19 -24.687 0 simundump kenz /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca/kenz 0 0 0 0 0 \ 75396 0.0003979 480 120 0 0 "" red orange "" 659.92 -24.817 0 simundump kreac /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca/diff 0 0.001 0.001 \ "" white black 659.19 -21.687 0 simundump kpool /kinetics/chain/kinetics[13]/PLA2/PLA2* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange darkgreen 656.97 -26.851 0 simundump kreac /kinetics/chain/kinetics[13]/PLA2/PLA2*/diff 0 0.001 0.001 "" \ white black 657.97 -23.851 0 simundump kreac /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca-act 1 7.958e-05 \ 0.1 "" white darkgreen 655.91 -24.752 0 simundump kreac /kinetics/chain/kinetics[13]/PLA2/dephosphorylate-PLA2* 1 \ 0.17 0 "" white darkgreen 652.31 -23.735 0 simundump kpool /kinetics/chain/kinetics[13]/temp-PIP2 1 -1e-12 2.5 2.5 \ 1.8849e+05 1.8849e+05 0 0 75396 4 /kinetics/dendgeom green black 650.2 \ -19.047 0 simundump group /kinetics/chain/kinetics[13]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 681 -1 0 simundump kpool /kinetics/chain/kinetics[13]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 672 -4 0 simundump kpool /kinetics/chain/kinetics[13]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 675 -4 0 simundump kpool /kinetics/chain/kinetics[13]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 672 -8 0 simundump kpool /kinetics/chain/kinetics[13]/MAPK/MAPK 0 -1e-12 3.5999 3.5999 \ 2.7142e+05 2.7142e+05 0 0 75396 0 /kinetics/dendgeom pink brown 672 -11 0 simundump kreac /kinetics/chain/kinetics[13]/MAPK/MAPK/diff 0 0.001 0.001 "" \ white black 673 -8 0 simundump kpool /kinetics/chain/kinetics[13]/MAPK/craf-1** 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink brown 678 -4 0 simundump kpool /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr 1 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange brown 675 -11 0 simundump kreac /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr/diff 0 0.001 0.001 \ "" white black 676 -8 0 simundump kpool /kinetics/chain/kinetics[13]/MAPK/MAPKK* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 679 -8 0 simundump kenz /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 674 -9 0 simundump kenz /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 679 -9 0 simundump kpool /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 675 -8 0 simundump kpool /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 671 -6 0 simundump kenz /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 674 -6 0 simundump kenz /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 677 -6 0 simundump kpool /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom red brown 671 -7 0 simundump kenz /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 674 -7 0 simundump kenz /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 677 -7 0 simundump kreac /kinetics/chain/kinetics[13]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 669 -3 0 simundump group /kinetics/chain/kinetics[13]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 680.51 4.351 0 simundump kreac /kinetics/chain/kinetics[13]/Ras/dephosph-GEF 1 1 0 "" white \ blue 675.07 5.881 0 simundump kpool /kinetics/chain/kinetics[13]/Ras/inact-GEF 1 -1e-12 0.1 0.1 \ 7539.6 7539.6 0 0 75396 0 /kinetics/dendgeom hotpink blue 678.45 6.352 0 simundump kenz /kinetics/chain/kinetics[13]/Ras/inact-GEF/basal_GEF_activity 0 \ 0 0 0 0 75396 1.313e-07 0.08 0.02 0 0 "" red hotpink "" 677 5 0 simundump kreac /kinetics/chain/kinetics[13]/Ras/inact-GEF/diff 0 0.001 0.001 \ "" white black 679.45 9.352 0 simundump kpool /kinetics/chain/kinetics[13]/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 672.45 5.246 0 simundump kenz /kinetics/chain/kinetics[13]/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 \ 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 673.09 4.086 0 simundump kreac /kinetics/chain/kinetics[13]/Ras/GEF*/diff 0 0.001 0.001 "" \ white black 673.45 8.246 0 simundump kpool /kinetics/chain/kinetics[13]/Ras/GTP-Ras 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange blue 678.56 1.084 0 simundump kpool /kinetics/chain/kinetics[13]/Ras/GDP-Ras 1 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink blue 672.13 2.165 0 simundump kreac /kinetics/chain/kinetics[13]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 675.1 1.5 0 simundump kreac /kinetics/chain/kinetics[13]/Ras/dephosph-GAP 1 0.1 0 "" \ white blue 670.02 3.524 0 simundump kpool /kinetics/chain/kinetics[13]/Ras/GAP* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red blue 667.35 2.349 0 simundump kreac /kinetics/chain/kinetics[13]/Ras/GAP*/diff 0 0.001 0.001 "" \ white black 668.35 5.349 0 simundump kpool /kinetics/chain/kinetics[13]/Ras/GAP 1 -1e-12 0.01 0.01 \ 753.96 753.96 0 0 75396 0 /kinetics/dendgeom red blue 672.66 0.338 0 simundump kenz /kinetics/chain/kinetics[13]/Ras/GAP/GAP-inact-ras 1 0 0 0 0 \ 75396 0.00065634 40 10 0 0 "" red red "" 675.01 0.403 0 simundump kreac /kinetics/chain/kinetics[13]/Ras/GAP/diff 0 0.001 0.001 "" \ white black 673.66 3.338 0 simundump kreac /kinetics/chain/kinetics[13]/Ras/CaM-bind-GEF 1 0.0026526 1 \ "" white blue 668.49 9.679 0 simundump kpool /kinetics/chain/kinetics[13]/Ras/CaM-GEF 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 671.34 7.58 0 simundump kenz /kinetics/chain/kinetics[13]/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 \ 0 0 75396 1.3131e-05 0.4 0.1 0 0 "" red pink "" 671.02 6.657 0 simundump kreac /kinetics/chain/kinetics[13]/Ras/CaM-GEF/diff 0 0.001 0.001 \ "" white black 672.34 10.58 0 simundump kpool /kinetics/chain/kinetics[13]/Ca 1 -1e-12 0.095 0.095 7162.6 \ 7162.6 0 0 75396 4 /kinetics/dendgeom red black 651 -13 0 simundump kpool /kinetics/chain/kinetics[13]/DAG 1 -1e-12 12.2 12.2 \ 9.1983e+05 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 666.72 \ -19.562 0 simundump kpool /kinetics/chain/kinetics[13]/PKC-active 1 -1e-12 0.3 \ 2.1196e-16 1.5981e-11 22619 0 0 75396 2 /kinetics/dendgeom red black 666 -3 \ 0 simundump kenz /kinetics/chain/kinetics[13]/PKC-active/PKC-act-raf 1 0 0 0 0 \ 75396 3.979e-06 16 4 0 0 "" red yellow "" 672 -2 0 simundump kenz /kinetics/chain/kinetics[13]/PKC-active/PKC-inact-GAP 1 0 0 0 \ 0 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 670 1 0 simundump kenz /kinetics/chain/kinetics[13]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 675 8 0 simundump kenz /kinetics/chain/kinetics[13]/PKC-active/phosph-AC2 1 0 0 0 0 \ 75396 0.00066667 16 4 0 0 "" red red "" 659.32 -23.269 0 simundump kpool /kinetics/chain/kinetics[13]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 679 -11 0 simundump kenz /kinetics/chain/kinetics[13]/MAPK*/MAPK* 0 0 0 0 0 75396 \ 2.5864e-05 40 10 0 0 "" red orange "" 654 -26 0 simundump kenz /kinetics/chain/kinetics[13]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange "" 676 -2 0 simundump kreac /kinetics/chain/kinetics[13]/MAPK*/diff 0 0.001 0.001 "" \ white black 680 -8 0 simundump kpool /kinetics/chain/kinetics[13]/IP3 1 -1e-12 0.73 0.73 55039 \ 55039 0 0 75396 4 /kinetics/dendgeom pink black 665.23 -16.656 0 simundump kpool /kinetics/chain/kinetics[13]/MKP-1 1 -1e-12 0.024 0.024 \ 1809.5 1809.5 0 0 75396 0 /kinetics/dendgeom hotpink black 671 -10 0 simundump kenz /kinetics/chain/kinetics[13]/MKP-1/MKP1-tyr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 672 -9 0 simundump kenz /kinetics/chain/kinetics[13]/MKP-1/MKP1-thr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 677 -9 0 simundump kreac /kinetics/chain/kinetics[13]/MKP-1/diff 0 0.001 0.001 "" \ white black 672 -7 0 simundump kpool /kinetics/chain/kinetics[13]/PPhosphatase2A 1 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom hotpink yellow 675 -3 0 simundump kenz /kinetics/chain/kinetics[13]/PPhosphatase2A/craf-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 674 -2 0 simundump kenz /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 677 -5 0 simundump kenz /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph-ser 1 0 \ 0 0 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 674 -5 0 simundump kenz /kinetics/chain/kinetics[13]/PPhosphatase2A/craf**-deph 1 0 0 \ 0 0 0.12566 2.5414e-05 24 6 0 0 "" red hotpink "" 678 -2 0 simundump kreac /kinetics/chain/kinetics[13]/PPhosphatase2A/diff 0 0.001 \ 0.001 "" white black 676 0 0 simundump group /kinetics/chain/kinetics[13]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 653 -9 0 simundump kpool /kinetics/chain/kinetics[13]/CaM/CaM 1 -1e-12 20 20 \ 1.5079e+06 1.5079e+06 0 0 75396 0 /kinetics/dendgeom pink blue 652.98 -1.28 \ 0 simundump kreac /kinetics/chain/kinetics[13]/CaM/CaM/diff 0 0.001 0.001 "" \ white black 653.98 1.72 0 simundump kreac /kinetics/chain/kinetics[13]/CaM/CaM-TR2-bind-Ca 1 1.2666e-08 \ 72 "" white blue 655.16 -1.921 0 simundump kreac /kinetics/chain/kinetics[13]/CaM/CaM-TR2-Ca2-bind-Ca 1 \ 4.7748e-05 10 "" white blue 654.16 -3.7747 0 simundump kreac /kinetics/chain/kinetics[13]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 652.6 -6.7404 0 simundump kpool /kinetics/chain/kinetics[13]/CaM/CaM-Ca3 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 656.49 -5.603 0 simundump kreac /kinetics/chain/kinetics[13]/CaM/CaM-Ca3/diff 0 0.001 0.001 \ "" white black 657.49 -2.603 0 simundump kpool /kinetics/chain/kinetics[13]/CaM/CaM-TR2-Ca2 1 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 658 -2.7423 0 simundump kreac /kinetics/chain/kinetics[13]/CaM/CaM-TR2-Ca2/diff 0 0.001 \ 0.001 "" white black 659 0.2577 0 simundump kpool /kinetics/chain/kinetics[13]/CaM/CaM-Ca4 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom blue blue 658 -8 0 simundump kreac /kinetics/chain/kinetics[13]/CaM/CaM-Ca4/diff 0 0.001 0.001 \ "" white black 659 -5 0 simundump kreac /kinetics/chain/kinetics[13]/Ras-act-unphosph-raf 0 7.958e-05 \ 1 "" white black 670 -4 0 simundump kpool /kinetics/chain/kinetics[13]/Ca_input 0 -1e-12 0.08 0.08 \ 6031.7 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 644 -7 0 simundump kreac /kinetics/chain/kinetics[13]/Ca_diff 0 2 2 "" white black 645 \ -12 0 simundump group /kinetics/chain/kinetics[14] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 704 0 0 simundump group /kinetics/chain/kinetics[14]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 712.95 -3.7837 0 simundump kpool /kinetics/chain/kinetics[14]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 711.92 -10.489 0 simundump kreac /kinetics/chain/kinetics[14]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 712.92 -7.489 0 simundump kreac /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 711.92 -12.123 0 simundump kreac /kinetics/chain/kinetics[14]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 713.94 -11.306 0 simundump kreac /kinetics/chain/kinetics[14]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 712.2 -7.7467 0 simundump kreac /kinetics/chain/kinetics[14]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 713.38 -9.2638 0 simundump kreac /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca-AA 0 \ 1.5916e-08 0.1 "" white blue 715.21 -8.1843 0 simundump kreac /kinetics/chain/kinetics[14]/PKC/PKC-act-by-DAG-AA 0 2 0.2 "" \ white blue 717.25 -8.7678 0 simundump kpool /kinetics/chain/kinetics[14]/PKC/PKC-DAG-AA* 0 -1e-12 \ 4.9137e-18 4.9137e-18 3.7047e-13 3.7047e-13 0 0 75396 0 /kinetics/dendgeom \ cyan blue 716.6 -6.463 0 simundump kreac /kinetics/chain/kinetics[14]/PKC/PKC-DAG-AA*/diff 0 0.001 \ 0.001 "" white black 717.6 -3.463 0 simundump kpool /kinetics/chain/kinetics[14]/PKC/PKC-Ca-AA* 0 -1e-12 \ 1.7501e-16 1.7501e-16 1.3195e-11 1.3195e-11 0 0 75396 0 /kinetics/dendgeom \ orange blue 715.4 -5.7044 0 simundump kreac /kinetics/chain/kinetics[14]/PKC/PKC-Ca-AA*/diff 0 0.001 \ 0.001 "" white black 716.4 -2.7044 0 simundump kpool /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb* 0 -1e-12 \ 1.3896e-17 1.3896e-17 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom \ pink blue 713.22 -5.471 0 simundump kreac /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb*/diff 0 0.001 \ 0.001 "" white black 714.22 -2.471 0 simundump kpool /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb* 0 -1e-12 \ 9.4351e-21 9.4351e-21 7.1137e-16 7.1137e-16 0 0 75396 0 /kinetics/dendgeom \ yellow blue 714.17 -6.4922 0 simundump kreac /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb*/diff 0 0.001 \ 0.001 "" white black 715.17 -3.4922 0 simundump kpool /kinetics/chain/kinetics[14]/PKC/PKC-basal* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 711.25 -6.4338 0 simundump kreac /kinetics/chain/kinetics[14]/PKC/PKC-basal*/diff 0 0.001 \ 0.001 "" white black 712.25 -3.4338 0 simundump kreac /kinetics/chain/kinetics[14]/PKC/PKC-basal-act 0 1 50 "" \ white blue 711.02 -8.9429 0 simundump kpool /kinetics/chain/kinetics[14]/PKC/PKC-AA* 0 -1e-12 1.8134e-17 \ 1.8134e-17 1.3672e-12 1.3672e-12 0 0 75396 0 /kinetics/dendgeom cyan blue \ 717.78 -5.1793 0 simundump kreac /kinetics/chain/kinetics[14]/PKC/PKC-AA*/diff 0 0.001 0.001 \ "" white black 718.78 -2.1793 0 simundump kreac /kinetics/chain/kinetics[14]/PKC/PKC-act-by-AA 0 1.5916e-09 \ 0.1 "" white blue 711.01 -13.865 0 simundump kpool /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG 0 -1e-12 \ 8.4632e-23 8.4632e-23 6.3809e-18 6.3809e-18 0 0 75396 0 /kinetics/dendgeom \ white blue 716.23 -10.197 0 simundump kreac /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG/diff 0 0.001 \ 0.001 "" white black 717.23 -7.197 0 simundump kreac /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 712.99 -13.99 0 simundump kpool /kinetics/chain/kinetics[14]/PKC/PKC-DAG 0 -1e-12 1.161e-16 \ 1.161e-16 8.7535e-12 8.7535e-12 0 0 75396 0 /kinetics/dendgeom white blue \ 715 -13.086 0 simundump kreac /kinetics/chain/kinetics[14]/PKC/PKC-DAG/diff 0 0.001 0.001 \ "" white black 716 -10.086 0 simundump kreac /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG-AA 0 2.3874e-07 2 \ "" white blue 714.77 -14.953 0 simundump kpool /kinetics/chain/kinetics[14]/PKC/PKC-DAG-AA 0 -1e-12 \ 2.5188e-19 2.5188e-19 1.8991e-14 1.8991e-14 0 0 75396 0 /kinetics/dendgeom \ white blue 716.62 -11.773 0 simundump kreac /kinetics/chain/kinetics[14]/PKC/PKC-DAG-AA/diff 0 0.001 \ 0.001 "" white black 717.62 -8.773 0 simundump kpool /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic 0 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom white blue 709.87 -11.403 0 simundump kreac /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic/diff 0 0.001 \ 0.001 "" white black 710.87 -8.403 0 simundump kpool /kinetics/chain/kinetics[14]/AA 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom darkgreen black 712.71 -21.338 0 simundump kreac /kinetics/chain/kinetics[14]/AA/diff 0 0.001 0.001 "" white \ black 713.71 -18.338 0 simundump group /kinetics/chain/kinetics[14]/PLA2 0 darkgreen black x 0 1 "" \ defaultfile defaultfile.g 0 0 0 708.64 -26.209 0 simundump kpool /kinetics/chain/kinetics[14]/PLA2/PLA2-cytosolic 0 -1e-12 \ 0.39999 0.39999 30158 30158 0 0 75396 0 /kinetics/dendgeom yellow darkgreen \ 704.18 -20.942 0 simundump kreac /kinetics/chain/kinetics[14]/PLA2/PLA2-cytosolic/diff 0 0.001 \ 0.001 "" white black 705.18 -17.942 0 simundump kreac /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca-act 0 1.3263e-05 \ 0.1 "" white darkgreen 704.9 -23.104 0 simundump kpool /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom yellow darkgreen 707.28 -23.646 0 simundump kenz /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca*/kenz 0 0 0 0 0 \ 75396 1.7906e-05 21.6 5.4 0 0 "" red yellow "" 709.94 -23.667 0 simundump kreac /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca*/diff 0 0.001 0.001 \ "" white black 708.28 -20.646 0 simundump kreac /kinetics/chain/kinetics[14]/PLA2/PIP2-PLA2-act 0 1.5916e-08 \ 0.5 "" white darkgreen 704.95 -18.75 0 simundump kpool /kinetics/chain/kinetics[14]/PLA2/PIP2-PLA2* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 707.32 -18.292 0 simundump kenz /kinetics/chain/kinetics[14]/PLA2/PIP2-PLA2*/kenz 0 0 0 0 0 \ 75396 3.6607e-05 44.16 11.04 0 0 "" red cyan "" 709.97 -18.271 0 simundump kreac /kinetics/chain/kinetics[14]/PLA2/PIP2-PLA2*/diff 0 0.001 \ 0.001 "" white black 708.32 -15.292 0 simundump kreac /kinetics/chain/kinetics[14]/PLA2/PIP2-Ca-PLA2-act 0 \ 1.5916e-07 0.1 "" white darkgreen 705.9 -19.5 0 simundump kpool /kinetics/chain/kinetics[14]/PLA2/PIP2-Ca-PLA2* 0 -1e-12 0 0 \ 0 0 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 707.67 -19.896 0 simundump kenz /kinetics/chain/kinetics[14]/PLA2/PIP2-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00011937 144 36 0 0 "" red cyan "" 710.03 -19.979 0 simundump kreac /kinetics/chain/kinetics[14]/PLA2/PIP2-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 708.67 -16.896 0 simundump kreac /kinetics/chain/kinetics[14]/PLA2/DAG-Ca-PLA2-act 0 3.979e-08 \ 4 "" white darkgreen 705.17 -21.834 0 simundump kpool /kinetics/chain/kinetics[14]/PLA2/DAG-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom pink darkgreen 707.86 -22.479 0 simundump kenz /kinetics/chain/kinetics[14]/PLA2/DAG-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00019895 240 60 0 0 "" red pink "" 710.05 -22.354 0 simundump kreac /kinetics/chain/kinetics[14]/PLA2/DAG-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 708.86 -19.479 0 simundump kpool /kinetics/chain/kinetics[14]/PLA2/APC 0 -1e-12 30 30 \ 2.2619e+06 2.2619e+06 0 0 75396 4 /kinetics/dendgeom yellow darkgreen \ 707.76 -21.963 0 simundump kreac /kinetics/chain/kinetics[14]/PLA2/Degrade-AA 1 0.4 0 "" white \ darkgreen 709.82 -17.288 0 simundump kpool /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange darkgreen 708.19 -24.687 0 simundump kenz /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca/kenz 0 0 0 0 0 \ 75396 0.0003979 480 120 0 0 "" red orange "" 709.92 -24.817 0 simundump kreac /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca/diff 0 0.001 0.001 \ "" white black 709.19 -21.687 0 simundump kpool /kinetics/chain/kinetics[14]/PLA2/PLA2* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange darkgreen 706.97 -26.851 0 simundump kreac /kinetics/chain/kinetics[14]/PLA2/PLA2*/diff 0 0.001 0.001 "" \ white black 707.97 -23.851 0 simundump kreac /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca-act 1 7.958e-05 \ 0.1 "" white darkgreen 705.91 -24.752 0 simundump kreac /kinetics/chain/kinetics[14]/PLA2/dephosphorylate-PLA2* 1 \ 0.17 0 "" white darkgreen 702.31 -23.735 0 simundump kpool /kinetics/chain/kinetics[14]/temp-PIP2 1 -1e-12 2.5 2.5 \ 1.8849e+05 1.8849e+05 0 0 75396 4 /kinetics/dendgeom green black 700.2 \ -19.047 0 simundump group /kinetics/chain/kinetics[14]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 731 -1 0 simundump kpool /kinetics/chain/kinetics[14]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 722 -4 0 simundump kpool /kinetics/chain/kinetics[14]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 725 -4 0 simundump kpool /kinetics/chain/kinetics[14]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 722 -8 0 simundump kpool /kinetics/chain/kinetics[14]/MAPK/MAPK 0 -1e-12 3.5999 3.5999 \ 2.7142e+05 2.7142e+05 0 0 75396 0 /kinetics/dendgeom pink brown 722 -11 0 simundump kreac /kinetics/chain/kinetics[14]/MAPK/MAPK/diff 0 0.001 0.001 "" \ white black 723 -8 0 simundump kpool /kinetics/chain/kinetics[14]/MAPK/craf-1** 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink brown 728 -4 0 simundump kpool /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr 1 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange brown 725 -11 0 simundump kreac /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr/diff 0 0.001 0.001 \ "" white black 726 -8 0 simundump kpool /kinetics/chain/kinetics[14]/MAPK/MAPKK* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 729 -8 0 simundump kenz /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 724 -9 0 simundump kenz /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 729 -9 0 simundump kpool /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 725 -8 0 simundump kpool /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 721 -6 0 simundump kenz /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 724 -6 0 simundump kenz /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 727 -6 0 simundump kpool /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom red brown 721 -7 0 simundump kenz /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 724 -7 0 simundump kenz /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 727 -7 0 simundump kreac /kinetics/chain/kinetics[14]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 719 -3 0 simundump group /kinetics/chain/kinetics[14]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 730.51 4.351 0 simundump kreac /kinetics/chain/kinetics[14]/Ras/dephosph-GEF 1 1 0 "" white \ blue 725.07 5.881 0 simundump kpool /kinetics/chain/kinetics[14]/Ras/inact-GEF 1 -1e-12 0.1 0.1 \ 7539.6 7539.6 0 0 75396 0 /kinetics/dendgeom hotpink blue 728.45 6.352 0 simundump kenz /kinetics/chain/kinetics[14]/Ras/inact-GEF/basal_GEF_activity 0 \ 0 0 0 0 75396 1.313e-07 0.08 0.02 0 0 "" red hotpink "" 727 5 0 simundump kreac /kinetics/chain/kinetics[14]/Ras/inact-GEF/diff 0 0.001 0.001 \ "" white black 729.45 9.352 0 simundump kpool /kinetics/chain/kinetics[14]/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 722.45 5.246 0 simundump kenz /kinetics/chain/kinetics[14]/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 \ 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 723.09 4.086 0 simundump kreac /kinetics/chain/kinetics[14]/Ras/GEF*/diff 0 0.001 0.001 "" \ white black 723.45 8.246 0 simundump kpool /kinetics/chain/kinetics[14]/Ras/GTP-Ras 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange blue 728.56 1.084 0 simundump kpool /kinetics/chain/kinetics[14]/Ras/GDP-Ras 1 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink blue 722.13 2.165 0 simundump kreac /kinetics/chain/kinetics[14]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 725.1 1.5 0 simundump kreac /kinetics/chain/kinetics[14]/Ras/dephosph-GAP 1 0.1 0 "" \ white blue 720.02 3.524 0 simundump kpool /kinetics/chain/kinetics[14]/Ras/GAP* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red blue 717.35 2.349 0 simundump kreac /kinetics/chain/kinetics[14]/Ras/GAP*/diff 0 0.001 0.001 "" \ white black 718.35 5.349 0 simundump kpool /kinetics/chain/kinetics[14]/Ras/GAP 1 -1e-12 0.01 0.01 \ 753.96 753.96 0 0 75396 0 /kinetics/dendgeom red blue 722.66 0.338 0 simundump kenz /kinetics/chain/kinetics[14]/Ras/GAP/GAP-inact-ras 1 0 0 0 0 \ 75396 0.00065634 40 10 0 0 "" red red "" 725.01 0.403 0 simundump kreac /kinetics/chain/kinetics[14]/Ras/GAP/diff 0 0.001 0.001 "" \ white black 723.66 3.338 0 simundump kreac /kinetics/chain/kinetics[14]/Ras/CaM-bind-GEF 1 0.0026526 1 \ "" white blue 718.49 9.679 0 simundump kpool /kinetics/chain/kinetics[14]/Ras/CaM-GEF 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 721.34 7.58 0 simundump kenz /kinetics/chain/kinetics[14]/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 \ 0 0 75396 1.3131e-05 0.4 0.1 0 0 "" red pink "" 721.02 6.657 0 simundump kreac /kinetics/chain/kinetics[14]/Ras/CaM-GEF/diff 0 0.001 0.001 \ "" white black 722.34 10.58 0 simundump kpool /kinetics/chain/kinetics[14]/Ca 1 -1e-12 0.095 0.095 7162.6 \ 7162.6 0 0 75396 4 /kinetics/dendgeom red black 701 -13 0 simundump kpool /kinetics/chain/kinetics[14]/DAG 1 -1e-12 12.2 12.2 \ 9.1983e+05 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 716.72 \ -19.562 0 simundump kpool /kinetics/chain/kinetics[14]/PKC-active 1 -1e-12 0.3 \ 2.1196e-16 1.5981e-11 22619 0 0 75396 2 /kinetics/dendgeom red black 716 -3 \ 0 simundump kenz /kinetics/chain/kinetics[14]/PKC-active/PKC-act-raf 1 0 0 0 0 \ 75396 3.979e-06 16 4 0 0 "" red yellow "" 722 -2 0 simundump kenz /kinetics/chain/kinetics[14]/PKC-active/PKC-inact-GAP 1 0 0 0 \ 0 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 720 1 0 simundump kenz /kinetics/chain/kinetics[14]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 725 8 0 simundump kenz /kinetics/chain/kinetics[14]/PKC-active/phosph-AC2 1 0 0 0 0 \ 75396 0.00066667 16 4 0 0 "" red red "" 709.32 -23.269 0 simundump kpool /kinetics/chain/kinetics[14]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 729 -11 0 simundump kenz /kinetics/chain/kinetics[14]/MAPK*/MAPK* 0 0 0 0 0 75396 \ 2.5864e-05 40 10 0 0 "" red orange "" 704 -26 0 simundump kenz /kinetics/chain/kinetics[14]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange "" 726 -2 0 simundump kreac /kinetics/chain/kinetics[14]/MAPK*/diff 0 0.001 0.001 "" \ white black 730 -8 0 simundump kpool /kinetics/chain/kinetics[14]/IP3 1 -1e-12 0.73 0.73 55039 \ 55039 0 0 75396 4 /kinetics/dendgeom pink black 715.23 -16.656 0 simundump kpool /kinetics/chain/kinetics[14]/MKP-1 1 -1e-12 0.024 0.024 \ 1809.5 1809.5 0 0 75396 0 /kinetics/dendgeom hotpink black 721 -10 0 simundump kenz /kinetics/chain/kinetics[14]/MKP-1/MKP1-tyr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 722 -9 0 simundump kenz /kinetics/chain/kinetics[14]/MKP-1/MKP1-thr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 727 -9 0 simundump kreac /kinetics/chain/kinetics[14]/MKP-1/diff 0 0.001 0.001 "" \ white black 722 -7 0 simundump kpool /kinetics/chain/kinetics[14]/PPhosphatase2A 1 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom hotpink yellow 725 -3 0 simundump kenz /kinetics/chain/kinetics[14]/PPhosphatase2A/craf-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 724 -2 0 simundump kenz /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 727 -5 0 simundump kenz /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph-ser 1 0 \ 0 0 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 724 -5 0 simundump kenz /kinetics/chain/kinetics[14]/PPhosphatase2A/craf**-deph 1 0 0 \ 0 0 0.12566 2.5414e-05 24 6 0 0 "" red hotpink "" 728 -2 0 simundump kreac /kinetics/chain/kinetics[14]/PPhosphatase2A/diff 0 0.001 \ 0.001 "" white black 726 0 0 simundump group /kinetics/chain/kinetics[14]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 703 -9 0 simundump kpool /kinetics/chain/kinetics[14]/CaM/CaM 1 -1e-12 20 20 \ 1.5079e+06 1.5079e+06 0 0 75396 0 /kinetics/dendgeom pink blue 702.98 -1.28 \ 0 simundump kreac /kinetics/chain/kinetics[14]/CaM/CaM/diff 0 0.001 0.001 "" \ white black 703.98 1.72 0 simundump kreac /kinetics/chain/kinetics[14]/CaM/CaM-TR2-bind-Ca 1 1.2666e-08 \ 72 "" white blue 705.16 -1.921 0 simundump kreac /kinetics/chain/kinetics[14]/CaM/CaM-TR2-Ca2-bind-Ca 1 \ 4.7748e-05 10 "" white blue 704.16 -3.7747 0 simundump kreac /kinetics/chain/kinetics[14]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 702.6 -6.7404 0 simundump kpool /kinetics/chain/kinetics[14]/CaM/CaM-Ca3 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 706.49 -5.603 0 simundump kreac /kinetics/chain/kinetics[14]/CaM/CaM-Ca3/diff 0 0.001 0.001 \ "" white black 707.49 -2.603 0 simundump kpool /kinetics/chain/kinetics[14]/CaM/CaM-TR2-Ca2 1 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 708 -2.7423 0 simundump kreac /kinetics/chain/kinetics[14]/CaM/CaM-TR2-Ca2/diff 0 0.001 \ 0.001 "" white black 709 0.2577 0 simundump kpool /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom blue blue 708 -8 0 simundump kreac /kinetics/chain/kinetics[14]/CaM/CaM-Ca4/diff 0 0.001 0.001 \ "" white black 709 -5 0 simundump kreac /kinetics/chain/kinetics[14]/Ras-act-unphosph-raf 0 7.958e-05 \ 1 "" white black 720 -4 0 simundump kpool /kinetics/chain/kinetics[14]/Ca_input 0 -1e-12 0.08 0.08 \ 6031.7 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 694 -7 0 simundump kreac /kinetics/chain/kinetics[14]/Ca_diff 0 2 2 "" white black 695 \ -12 0 simundump group /kinetics/chain/kinetics[15] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 754 0 0 simundump group /kinetics/chain/kinetics[15]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 762.95 -3.7837 0 simundump kpool /kinetics/chain/kinetics[15]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 761.92 -10.489 0 simundump kreac /kinetics/chain/kinetics[15]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 762.92 -7.489 0 simundump kreac /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 761.92 -12.123 0 simundump kreac /kinetics/chain/kinetics[15]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 763.94 -11.306 0 simundump kreac /kinetics/chain/kinetics[15]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 762.2 -7.7467 0 simundump kreac /kinetics/chain/kinetics[15]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 763.38 -9.2638 0 simundump kreac /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca-AA 0 \ 1.5916e-08 0.1 "" white blue 765.21 -8.1843 0 simundump kreac /kinetics/chain/kinetics[15]/PKC/PKC-act-by-DAG-AA 0 2 0.2 "" \ white blue 767.25 -8.7678 0 simundump kpool /kinetics/chain/kinetics[15]/PKC/PKC-DAG-AA* 0 -1e-12 \ 4.9137e-18 4.9137e-18 3.7047e-13 3.7047e-13 0 0 75396 0 /kinetics/dendgeom \ cyan blue 766.6 -6.463 0 simundump kreac /kinetics/chain/kinetics[15]/PKC/PKC-DAG-AA*/diff 0 0.001 \ 0.001 "" white black 767.6 -3.463 0 simundump kpool /kinetics/chain/kinetics[15]/PKC/PKC-Ca-AA* 0 -1e-12 \ 1.7501e-16 1.7501e-16 1.3195e-11 1.3195e-11 0 0 75396 0 /kinetics/dendgeom \ orange blue 765.4 -5.7044 0 simundump kreac /kinetics/chain/kinetics[15]/PKC/PKC-Ca-AA*/diff 0 0.001 \ 0.001 "" white black 766.4 -2.7044 0 simundump kpool /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb* 0 -1e-12 \ 1.3896e-17 1.3896e-17 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom \ pink blue 763.22 -5.471 0 simundump kreac /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb*/diff 0 0.001 \ 0.001 "" white black 764.22 -2.471 0 simundump kpool /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb* 0 -1e-12 \ 9.4351e-21 9.4351e-21 7.1137e-16 7.1137e-16 0 0 75396 0 /kinetics/dendgeom \ yellow blue 764.17 -6.4922 0 simundump kreac /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb*/diff 0 0.001 \ 0.001 "" white black 765.17 -3.4922 0 simundump kpool /kinetics/chain/kinetics[15]/PKC/PKC-basal* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 761.25 -6.4338 0 simundump kreac /kinetics/chain/kinetics[15]/PKC/PKC-basal*/diff 0 0.001 \ 0.001 "" white black 762.25 -3.4338 0 simundump kreac /kinetics/chain/kinetics[15]/PKC/PKC-basal-act 0 1 50 "" \ white blue 761.02 -8.9429 0 simundump kpool /kinetics/chain/kinetics[15]/PKC/PKC-AA* 0 -1e-12 1.8134e-17 \ 1.8134e-17 1.3672e-12 1.3672e-12 0 0 75396 0 /kinetics/dendgeom cyan blue \ 767.78 -5.1793 0 simundump kreac /kinetics/chain/kinetics[15]/PKC/PKC-AA*/diff 0 0.001 0.001 \ "" white black 768.78 -2.1793 0 simundump kreac /kinetics/chain/kinetics[15]/PKC/PKC-act-by-AA 0 1.5916e-09 \ 0.1 "" white blue 761.01 -13.865 0 simundump kpool /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG 0 -1e-12 \ 8.4632e-23 8.4632e-23 6.3809e-18 6.3809e-18 0 0 75396 0 /kinetics/dendgeom \ white blue 766.23 -10.197 0 simundump kreac /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG/diff 0 0.001 \ 0.001 "" white black 767.23 -7.197 0 simundump kreac /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 762.99 -13.99 0 simundump kpool /kinetics/chain/kinetics[15]/PKC/PKC-DAG 0 -1e-12 1.161e-16 \ 1.161e-16 8.7535e-12 8.7535e-12 0 0 75396 0 /kinetics/dendgeom white blue \ 765 -13.086 0 simundump kreac /kinetics/chain/kinetics[15]/PKC/PKC-DAG/diff 0 0.001 0.001 \ "" white black 766 -10.086 0 simundump kreac /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG-AA 0 2.3874e-07 2 \ "" white blue 764.77 -14.953 0 simundump kpool /kinetics/chain/kinetics[15]/PKC/PKC-DAG-AA 0 -1e-12 \ 2.5188e-19 2.5188e-19 1.8991e-14 1.8991e-14 0 0 75396 0 /kinetics/dendgeom \ white blue 766.62 -11.773 0 simundump kreac /kinetics/chain/kinetics[15]/PKC/PKC-DAG-AA/diff 0 0.001 \ 0.001 "" white black 767.62 -8.773 0 simundump kpool /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic 0 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom white blue 759.87 -11.403 0 simundump kreac /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic/diff 0 0.001 \ 0.001 "" white black 760.87 -8.403 0 simundump kpool /kinetics/chain/kinetics[15]/AA 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom darkgreen black 762.71 -21.338 0 simundump kreac /kinetics/chain/kinetics[15]/AA/diff 0 0.001 0.001 "" white \ black 763.71 -18.338 0 simundump group /kinetics/chain/kinetics[15]/PLA2 0 darkgreen black x 0 1 "" \ defaultfile defaultfile.g 0 0 0 758.64 -26.209 0 simundump kpool /kinetics/chain/kinetics[15]/PLA2/PLA2-cytosolic 0 -1e-12 \ 0.39999 0.39999 30158 30158 0 0 75396 0 /kinetics/dendgeom yellow darkgreen \ 754.18 -20.942 0 simundump kreac /kinetics/chain/kinetics[15]/PLA2/PLA2-cytosolic/diff 0 0.001 \ 0.001 "" white black 755.18 -17.942 0 simundump kreac /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca-act 0 1.3263e-05 \ 0.1 "" white darkgreen 754.9 -23.104 0 simundump kpool /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom yellow darkgreen 757.28 -23.646 0 simundump kenz /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca*/kenz 0 0 0 0 0 \ 75396 1.7906e-05 21.6 5.4 0 0 "" red yellow "" 759.94 -23.667 0 simundump kreac /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca*/diff 0 0.001 0.001 \ "" white black 758.28 -20.646 0 simundump kreac /kinetics/chain/kinetics[15]/PLA2/PIP2-PLA2-act 0 1.5916e-08 \ 0.5 "" white darkgreen 754.95 -18.75 0 simundump kpool /kinetics/chain/kinetics[15]/PLA2/PIP2-PLA2* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 757.32 -18.292 0 simundump kenz /kinetics/chain/kinetics[15]/PLA2/PIP2-PLA2*/kenz 0 0 0 0 0 \ 75396 3.6607e-05 44.16 11.04 0 0 "" red cyan "" 759.97 -18.271 0 simundump kreac /kinetics/chain/kinetics[15]/PLA2/PIP2-PLA2*/diff 0 0.001 \ 0.001 "" white black 758.32 -15.292 0 simundump kreac /kinetics/chain/kinetics[15]/PLA2/PIP2-Ca-PLA2-act 0 \ 1.5916e-07 0.1 "" white darkgreen 755.9 -19.5 0 simundump kpool /kinetics/chain/kinetics[15]/PLA2/PIP2-Ca-PLA2* 0 -1e-12 0 0 \ 0 0 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 757.67 -19.896 0 simundump kenz /kinetics/chain/kinetics[15]/PLA2/PIP2-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00011937 144 36 0 0 "" red cyan "" 760.03 -19.979 0 simundump kreac /kinetics/chain/kinetics[15]/PLA2/PIP2-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 758.67 -16.896 0 simundump kreac /kinetics/chain/kinetics[15]/PLA2/DAG-Ca-PLA2-act 0 3.979e-08 \ 4 "" white darkgreen 755.17 -21.834 0 simundump kpool /kinetics/chain/kinetics[15]/PLA2/DAG-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom pink darkgreen 757.86 -22.479 0 simundump kenz /kinetics/chain/kinetics[15]/PLA2/DAG-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00019895 240 60 0 0 "" red pink "" 760.05 -22.354 0 simundump kreac /kinetics/chain/kinetics[15]/PLA2/DAG-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 758.86 -19.479 0 simundump kpool /kinetics/chain/kinetics[15]/PLA2/APC 0 -1e-12 30 30 \ 2.2619e+06 2.2619e+06 0 0 75396 4 /kinetics/dendgeom yellow darkgreen \ 757.76 -21.963 0 simundump kreac /kinetics/chain/kinetics[15]/PLA2/Degrade-AA 1 0.4 0 "" white \ darkgreen 759.82 -17.288 0 simundump kpool /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange darkgreen 758.19 -24.687 0 simundump kenz /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca/kenz 0 0 0 0 0 \ 75396 0.0003979 480 120 0 0 "" red orange "" 759.92 -24.817 0 simundump kreac /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca/diff 0 0.001 0.001 \ "" white black 759.19 -21.687 0 simundump kpool /kinetics/chain/kinetics[15]/PLA2/PLA2* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange darkgreen 756.97 -26.851 0 simundump kreac /kinetics/chain/kinetics[15]/PLA2/PLA2*/diff 0 0.001 0.001 "" \ white black 757.97 -23.851 0 simundump kreac /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca-act 1 7.958e-05 \ 0.1 "" white darkgreen 755.91 -24.752 0 simundump kreac /kinetics/chain/kinetics[15]/PLA2/dephosphorylate-PLA2* 1 \ 0.17 0 "" white darkgreen 752.31 -23.735 0 simundump kpool /kinetics/chain/kinetics[15]/temp-PIP2 1 -1e-12 2.5 2.5 \ 1.8849e+05 1.8849e+05 0 0 75396 4 /kinetics/dendgeom green black 750.2 \ -19.047 0 simundump group /kinetics/chain/kinetics[15]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 781 -1 0 simundump kpool /kinetics/chain/kinetics[15]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 772 -4 0 simundump kpool /kinetics/chain/kinetics[15]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 775 -4 0 simundump kpool /kinetics/chain/kinetics[15]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 772 -8 0 simundump kpool /kinetics/chain/kinetics[15]/MAPK/MAPK 0 -1e-12 3.5999 3.5999 \ 2.7142e+05 2.7142e+05 0 0 75396 0 /kinetics/dendgeom pink brown 772 -11 0 simundump kreac /kinetics/chain/kinetics[15]/MAPK/MAPK/diff 0 0.001 0.001 "" \ white black 773 -8 0 simundump kpool /kinetics/chain/kinetics[15]/MAPK/craf-1** 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink brown 778 -4 0 simundump kpool /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr 1 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange brown 775 -11 0 simundump kreac /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr/diff 0 0.001 0.001 \ "" white black 776 -8 0 simundump kpool /kinetics/chain/kinetics[15]/MAPK/MAPKK* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 779 -8 0 simundump kenz /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 774 -9 0 simundump kenz /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 779 -9 0 simundump kpool /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 775 -8 0 simundump kpool /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 771 -6 0 simundump kenz /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 774 -6 0 simundump kenz /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 777 -6 0 simundump kpool /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom red brown 771 -7 0 simundump kenz /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 774 -7 0 simundump kenz /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 777 -7 0 simundump kreac /kinetics/chain/kinetics[15]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 769 -3 0 simundump group /kinetics/chain/kinetics[15]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 780.51 4.351 0 simundump kreac /kinetics/chain/kinetics[15]/Ras/dephosph-GEF 1 1 0 "" white \ blue 775.07 5.881 0 simundump kpool /kinetics/chain/kinetics[15]/Ras/inact-GEF 1 -1e-12 0.1 0.1 \ 7539.6 7539.6 0 0 75396 0 /kinetics/dendgeom hotpink blue 778.45 6.352 0 simundump kenz /kinetics/chain/kinetics[15]/Ras/inact-GEF/basal_GEF_activity 0 \ 0 0 0 0 75396 1.313e-07 0.08 0.02 0 0 "" red hotpink "" 777 5 0 simundump kreac /kinetics/chain/kinetics[15]/Ras/inact-GEF/diff 0 0.001 0.001 \ "" white black 779.45 9.352 0 simundump kpool /kinetics/chain/kinetics[15]/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 772.45 5.246 0 simundump kenz /kinetics/chain/kinetics[15]/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 \ 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 773.09 4.086 0 simundump kreac /kinetics/chain/kinetics[15]/Ras/GEF*/diff 0 0.001 0.001 "" \ white black 773.45 8.246 0 simundump kpool /kinetics/chain/kinetics[15]/Ras/GTP-Ras 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange blue 778.56 1.084 0 simundump kpool /kinetics/chain/kinetics[15]/Ras/GDP-Ras 1 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink blue 772.13 2.165 0 simundump kreac /kinetics/chain/kinetics[15]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 775.1 1.5 0 simundump kreac /kinetics/chain/kinetics[15]/Ras/dephosph-GAP 1 0.1 0 "" \ white blue 770.02 3.524 0 simundump kpool /kinetics/chain/kinetics[15]/Ras/GAP* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red blue 767.35 2.349 0 simundump kreac /kinetics/chain/kinetics[15]/Ras/GAP*/diff 0 0.001 0.001 "" \ white black 768.35 5.349 0 simundump kpool /kinetics/chain/kinetics[15]/Ras/GAP 1 -1e-12 0.01 0.01 \ 753.96 753.96 0 0 75396 0 /kinetics/dendgeom red blue 772.66 0.338 0 simundump kenz /kinetics/chain/kinetics[15]/Ras/GAP/GAP-inact-ras 1 0 0 0 0 \ 75396 0.00065634 40 10 0 0 "" red red "" 775.01 0.403 0 simundump kreac /kinetics/chain/kinetics[15]/Ras/GAP/diff 0 0.001 0.001 "" \ white black 773.66 3.338 0 simundump kreac /kinetics/chain/kinetics[15]/Ras/CaM-bind-GEF 1 0.0026526 1 \ "" white blue 768.49 9.679 0 simundump kpool /kinetics/chain/kinetics[15]/Ras/CaM-GEF 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 771.34 7.58 0 simundump kenz /kinetics/chain/kinetics[15]/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 \ 0 0 75396 1.3131e-05 0.4 0.1 0 0 "" red pink "" 771.02 6.657 0 simundump kreac /kinetics/chain/kinetics[15]/Ras/CaM-GEF/diff 0 0.001 0.001 \ "" white black 772.34 10.58 0 simundump kpool /kinetics/chain/kinetics[15]/Ca 1 -1e-12 0.095 0.095 7162.6 \ 7162.6 0 0 75396 4 /kinetics/dendgeom red black 751 -13 0 simundump kpool /kinetics/chain/kinetics[15]/DAG 1 -1e-12 12.2 12.2 \ 9.1983e+05 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 766.72 \ -19.562 0 simundump kpool /kinetics/chain/kinetics[15]/PKC-active 1 -1e-12 0.3 \ 2.1196e-16 1.5981e-11 22619 0 0 75396 2 /kinetics/dendgeom red black 766 -3 \ 0 simundump kenz /kinetics/chain/kinetics[15]/PKC-active/PKC-act-raf 1 0 0 0 0 \ 75396 3.979e-06 16 4 0 0 "" red yellow "" 772 -2 0 simundump kenz /kinetics/chain/kinetics[15]/PKC-active/PKC-inact-GAP 1 0 0 0 \ 0 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 770 1 0 simundump kenz /kinetics/chain/kinetics[15]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 775 8 0 simundump kenz /kinetics/chain/kinetics[15]/PKC-active/phosph-AC2 1 0 0 0 0 \ 75396 0.00066667 16 4 0 0 "" red red "" 759.32 -23.269 0 simundump kpool /kinetics/chain/kinetics[15]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 779 -11 0 simundump kenz /kinetics/chain/kinetics[15]/MAPK*/MAPK* 0 0 0 0 0 75396 \ 2.5864e-05 40 10 0 0 "" red orange "" 754 -26 0 simundump kenz /kinetics/chain/kinetics[15]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange "" 776 -2 0 simundump kreac /kinetics/chain/kinetics[15]/MAPK*/diff 0 0.001 0.001 "" \ white black 780 -8 0 simundump kpool /kinetics/chain/kinetics[15]/IP3 1 -1e-12 0.73 0.73 55039 \ 55039 0 0 75396 4 /kinetics/dendgeom pink black 765.23 -16.656 0 simundump kpool /kinetics/chain/kinetics[15]/MKP-1 1 -1e-12 0.024 0.024 \ 1809.5 1809.5 0 0 75396 0 /kinetics/dendgeom hotpink black 771 -10 0 simundump kenz /kinetics/chain/kinetics[15]/MKP-1/MKP1-tyr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 772 -9 0 simundump kenz /kinetics/chain/kinetics[15]/MKP-1/MKP1-thr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 777 -9 0 simundump kreac /kinetics/chain/kinetics[15]/MKP-1/diff 0 0.001 0.001 "" \ white black 772 -7 0 simundump kpool /kinetics/chain/kinetics[15]/PPhosphatase2A 1 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom hotpink yellow 775 -3 0 simundump kenz /kinetics/chain/kinetics[15]/PPhosphatase2A/craf-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 774 -2 0 simundump kenz /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 777 -5 0 simundump kenz /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph-ser 1 0 \ 0 0 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 774 -5 0 simundump kenz /kinetics/chain/kinetics[15]/PPhosphatase2A/craf**-deph 1 0 0 \ 0 0 0.12566 2.5414e-05 24 6 0 0 "" red hotpink "" 778 -2 0 simundump kreac /kinetics/chain/kinetics[15]/PPhosphatase2A/diff 0 0.001 \ 0.001 "" white black 776 0 0 simundump group /kinetics/chain/kinetics[15]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 753 -9 0 simundump kpool /kinetics/chain/kinetics[15]/CaM/CaM 1 -1e-12 20 20 \ 1.5079e+06 1.5079e+06 0 0 75396 0 /kinetics/dendgeom pink blue 752.98 -1.28 \ 0 simundump kreac /kinetics/chain/kinetics[15]/CaM/CaM/diff 0 0.001 0.001 "" \ white black 753.98 1.72 0 simundump kreac /kinetics/chain/kinetics[15]/CaM/CaM-TR2-bind-Ca 1 1.2666e-08 \ 72 "" white blue 755.16 -1.921 0 simundump kreac /kinetics/chain/kinetics[15]/CaM/CaM-TR2-Ca2-bind-Ca 1 \ 4.7748e-05 10 "" white blue 754.16 -3.7747 0 simundump kreac /kinetics/chain/kinetics[15]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 752.6 -6.7404 0 simundump kpool /kinetics/chain/kinetics[15]/CaM/CaM-Ca3 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 756.49 -5.603 0 simundump kreac /kinetics/chain/kinetics[15]/CaM/CaM-Ca3/diff 0 0.001 0.001 \ "" white black 757.49 -2.603 0 simundump kpool /kinetics/chain/kinetics[15]/CaM/CaM-TR2-Ca2 1 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 758 -2.7423 0 simundump kreac /kinetics/chain/kinetics[15]/CaM/CaM-TR2-Ca2/diff 0 0.001 \ 0.001 "" white black 759 0.2577 0 simundump kpool /kinetics/chain/kinetics[15]/CaM/CaM-Ca4 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom blue blue 758 -8 0 simundump kreac /kinetics/chain/kinetics[15]/CaM/CaM-Ca4/diff 0 0.001 0.001 \ "" white black 759 -5 0 simundump kreac /kinetics/chain/kinetics[15]/Ras-act-unphosph-raf 0 7.958e-05 \ 1 "" white black 770 -4 0 simundump kpool /kinetics/chain/kinetics[15]/Ca_input 0 -1e-12 0.08 0.08 \ 6031.7 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 744 -7 0 simundump kreac /kinetics/chain/kinetics[15]/Ca_diff 0 2 2 "" white black 745 \ -12 0 simundump group /kinetics/chain/kinetics[16] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 804 0 0 simundump group /kinetics/chain/kinetics[16]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 812.95 -3.7837 0 simundump kpool /kinetics/chain/kinetics[16]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 811.92 -10.489 0 simundump kreac /kinetics/chain/kinetics[16]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 812.92 -7.489 0 simundump kreac /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 811.92 -12.123 0 simundump kreac /kinetics/chain/kinetics[16]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 813.94 -11.306 0 simundump kreac /kinetics/chain/kinetics[16]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 812.2 -7.7467 0 simundump kreac /kinetics/chain/kinetics[16]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 813.38 -9.2638 0 simundump kreac /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca-AA 0 \ 1.5916e-08 0.1 "" white blue 815.21 -8.1843 0 simundump kreac /kinetics/chain/kinetics[16]/PKC/PKC-act-by-DAG-AA 0 2 0.2 "" \ white blue 817.25 -8.7678 0 simundump kpool /kinetics/chain/kinetics[16]/PKC/PKC-DAG-AA* 0 -1e-12 \ 4.9137e-18 4.9137e-18 3.7047e-13 3.7047e-13 0 0 75396 0 /kinetics/dendgeom \ cyan blue 816.6 -6.463 0 simundump kreac /kinetics/chain/kinetics[16]/PKC/PKC-DAG-AA*/diff 0 0.001 \ 0.001 "" white black 817.6 -3.463 0 simundump kpool /kinetics/chain/kinetics[16]/PKC/PKC-Ca-AA* 0 -1e-12 \ 1.7501e-16 1.7501e-16 1.3195e-11 1.3195e-11 0 0 75396 0 /kinetics/dendgeom \ orange blue 815.4 -5.7044 0 simundump kreac /kinetics/chain/kinetics[16]/PKC/PKC-Ca-AA*/diff 0 0.001 \ 0.001 "" white black 816.4 -2.7044 0 simundump kpool /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb* 0 -1e-12 \ 1.3896e-17 1.3896e-17 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom \ pink blue 813.22 -5.471 0 simundump kreac /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb*/diff 0 0.001 \ 0.001 "" white black 814.22 -2.471 0 simundump kpool /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb* 0 -1e-12 \ 9.4351e-21 9.4351e-21 7.1137e-16 7.1137e-16 0 0 75396 0 /kinetics/dendgeom \ yellow blue 814.17 -6.4922 0 simundump kreac /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb*/diff 0 0.001 \ 0.001 "" white black 815.17 -3.4922 0 simundump kpool /kinetics/chain/kinetics[16]/PKC/PKC-basal* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 811.25 -6.4338 0 simundump kreac /kinetics/chain/kinetics[16]/PKC/PKC-basal*/diff 0 0.001 \ 0.001 "" white black 812.25 -3.4338 0 simundump kreac /kinetics/chain/kinetics[16]/PKC/PKC-basal-act 0 1 50 "" \ white blue 811.02 -8.9429 0 simundump kpool /kinetics/chain/kinetics[16]/PKC/PKC-AA* 0 -1e-12 1.8134e-17 \ 1.8134e-17 1.3672e-12 1.3672e-12 0 0 75396 0 /kinetics/dendgeom cyan blue \ 817.78 -5.1793 0 simundump kreac /kinetics/chain/kinetics[16]/PKC/PKC-AA*/diff 0 0.001 0.001 \ "" white black 818.78 -2.1793 0 simundump kreac /kinetics/chain/kinetics[16]/PKC/PKC-act-by-AA 0 1.5916e-09 \ 0.1 "" white blue 811.01 -13.865 0 simundump kpool /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG 0 -1e-12 \ 8.4632e-23 8.4632e-23 6.3809e-18 6.3809e-18 0 0 75396 0 /kinetics/dendgeom \ white blue 816.23 -10.197 0 simundump kreac /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG/diff 0 0.001 \ 0.001 "" white black 817.23 -7.197 0 simundump kreac /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 812.99 -13.99 0 simundump kpool /kinetics/chain/kinetics[16]/PKC/PKC-DAG 0 -1e-12 1.161e-16 \ 1.161e-16 8.7535e-12 8.7535e-12 0 0 75396 0 /kinetics/dendgeom white blue \ 815 -13.086 0 simundump kreac /kinetics/chain/kinetics[16]/PKC/PKC-DAG/diff 0 0.001 0.001 \ "" white black 816 -10.086 0 simundump kreac /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG-AA 0 2.3874e-07 2 \ "" white blue 814.77 -14.953 0 simundump kpool /kinetics/chain/kinetics[16]/PKC/PKC-DAG-AA 0 -1e-12 \ 2.5188e-19 2.5188e-19 1.8991e-14 1.8991e-14 0 0 75396 0 /kinetics/dendgeom \ white blue 816.62 -11.773 0 simundump kreac /kinetics/chain/kinetics[16]/PKC/PKC-DAG-AA/diff 0 0.001 \ 0.001 "" white black 817.62 -8.773 0 simundump kpool /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic 0 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom white blue 809.87 -11.403 0 simundump kreac /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic/diff 0 0.001 \ 0.001 "" white black 810.87 -8.403 0 simundump kpool /kinetics/chain/kinetics[16]/AA 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom darkgreen black 812.71 -21.338 0 simundump kreac /kinetics/chain/kinetics[16]/AA/diff 0 0.001 0.001 "" white \ black 813.71 -18.338 0 simundump group /kinetics/chain/kinetics[16]/PLA2 0 darkgreen black x 0 1 "" \ defaultfile defaultfile.g 0 0 0 808.64 -26.209 0 simundump kpool /kinetics/chain/kinetics[16]/PLA2/PLA2-cytosolic 0 -1e-12 \ 0.39999 0.39999 30158 30158 0 0 75396 0 /kinetics/dendgeom yellow darkgreen \ 804.18 -20.942 0 simundump kreac /kinetics/chain/kinetics[16]/PLA2/PLA2-cytosolic/diff 0 0.001 \ 0.001 "" white black 805.18 -17.942 0 simundump kreac /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca-act 0 1.3263e-05 \ 0.1 "" white darkgreen 804.9 -23.104 0 simundump kpool /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom yellow darkgreen 807.28 -23.646 0 simundump kenz /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca*/kenz 0 0 0 0 0 \ 75396 1.7906e-05 21.6 5.4 0 0 "" red yellow "" 809.94 -23.667 0 simundump kreac /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca*/diff 0 0.001 0.001 \ "" white black 808.28 -20.646 0 simundump kreac /kinetics/chain/kinetics[16]/PLA2/PIP2-PLA2-act 0 1.5916e-08 \ 0.5 "" white darkgreen 804.95 -18.75 0 simundump kpool /kinetics/chain/kinetics[16]/PLA2/PIP2-PLA2* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 807.32 -18.292 0 simundump kenz /kinetics/chain/kinetics[16]/PLA2/PIP2-PLA2*/kenz 0 0 0 0 0 \ 75396 3.6607e-05 44.16 11.04 0 0 "" red cyan "" 809.97 -18.271 0 simundump kreac /kinetics/chain/kinetics[16]/PLA2/PIP2-PLA2*/diff 0 0.001 \ 0.001 "" white black 808.32 -15.292 0 simundump kreac /kinetics/chain/kinetics[16]/PLA2/PIP2-Ca-PLA2-act 0 \ 1.5916e-07 0.1 "" white darkgreen 805.9 -19.5 0 simundump kpool /kinetics/chain/kinetics[16]/PLA2/PIP2-Ca-PLA2* 0 -1e-12 0 0 \ 0 0 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 807.67 -19.896 0 simundump kenz /kinetics/chain/kinetics[16]/PLA2/PIP2-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00011937 144 36 0 0 "" red cyan "" 810.03 -19.979 0 simundump kreac /kinetics/chain/kinetics[16]/PLA2/PIP2-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 808.67 -16.896 0 simundump kreac /kinetics/chain/kinetics[16]/PLA2/DAG-Ca-PLA2-act 0 3.979e-08 \ 4 "" white darkgreen 805.17 -21.834 0 simundump kpool /kinetics/chain/kinetics[16]/PLA2/DAG-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom pink darkgreen 807.86 -22.479 0 simundump kenz /kinetics/chain/kinetics[16]/PLA2/DAG-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00019895 240 60 0 0 "" red pink "" 810.05 -22.354 0 simundump kreac /kinetics/chain/kinetics[16]/PLA2/DAG-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 808.86 -19.479 0 simundump kpool /kinetics/chain/kinetics[16]/PLA2/APC 0 -1e-12 30 30 \ 2.2619e+06 2.2619e+06 0 0 75396 4 /kinetics/dendgeom yellow darkgreen \ 807.76 -21.963 0 simundump kreac /kinetics/chain/kinetics[16]/PLA2/Degrade-AA 1 0.4 0 "" white \ darkgreen 809.82 -17.288 0 simundump kpool /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange darkgreen 808.19 -24.687 0 simundump kenz /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca/kenz 0 0 0 0 0 \ 75396 0.0003979 480 120 0 0 "" red orange "" 809.92 -24.817 0 simundump kreac /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca/diff 0 0.001 0.001 \ "" white black 809.19 -21.687 0 simundump kpool /kinetics/chain/kinetics[16]/PLA2/PLA2* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange darkgreen 806.97 -26.851 0 simundump kreac /kinetics/chain/kinetics[16]/PLA2/PLA2*/diff 0 0.001 0.001 "" \ white black 807.97 -23.851 0 simundump kreac /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca-act 1 7.958e-05 \ 0.1 "" white darkgreen 805.91 -24.752 0 simundump kreac /kinetics/chain/kinetics[16]/PLA2/dephosphorylate-PLA2* 1 \ 0.17 0 "" white darkgreen 802.31 -23.735 0 simundump kpool /kinetics/chain/kinetics[16]/temp-PIP2 1 -1e-12 2.5 2.5 \ 1.8849e+05 1.8849e+05 0 0 75396 4 /kinetics/dendgeom green black 800.2 \ -19.047 0 simundump group /kinetics/chain/kinetics[16]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 831 -1 0 simundump kpool /kinetics/chain/kinetics[16]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 822 -4 0 simundump kpool /kinetics/chain/kinetics[16]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 825 -4 0 simundump kpool /kinetics/chain/kinetics[16]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 822 -8 0 simundump kpool /kinetics/chain/kinetics[16]/MAPK/MAPK 0 -1e-12 3.5999 3.5999 \ 2.7142e+05 2.7142e+05 0 0 75396 0 /kinetics/dendgeom pink brown 822 -11 0 simundump kreac /kinetics/chain/kinetics[16]/MAPK/MAPK/diff 0 0.001 0.001 "" \ white black 823 -8 0 simundump kpool /kinetics/chain/kinetics[16]/MAPK/craf-1** 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink brown 828 -4 0 simundump kpool /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr 1 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange brown 825 -11 0 simundump kreac /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr/diff 0 0.001 0.001 \ "" white black 826 -8 0 simundump kpool /kinetics/chain/kinetics[16]/MAPK/MAPKK* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 829 -8 0 simundump kenz /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 824 -9 0 simundump kenz /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 829 -9 0 simundump kpool /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 825 -8 0 simundump kpool /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 821 -6 0 simundump kenz /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 824 -6 0 simundump kenz /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 827 -6 0 simundump kpool /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom red brown 821 -7 0 simundump kenz /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 824 -7 0 simundump kenz /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 827 -7 0 simundump kreac /kinetics/chain/kinetics[16]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 819 -3 0 simundump group /kinetics/chain/kinetics[16]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 830.51 4.351 0 simundump kreac /kinetics/chain/kinetics[16]/Ras/dephosph-GEF 1 1 0 "" white \ blue 825.07 5.881 0 simundump kpool /kinetics/chain/kinetics[16]/Ras/inact-GEF 1 -1e-12 0.1 0.1 \ 7539.6 7539.6 0 0 75396 0 /kinetics/dendgeom hotpink blue 828.45 6.352 0 simundump kenz /kinetics/chain/kinetics[16]/Ras/inact-GEF/basal_GEF_activity 0 \ 0 0 0 0 75396 1.313e-07 0.08 0.02 0 0 "" red hotpink "" 827 5 0 simundump kreac /kinetics/chain/kinetics[16]/Ras/inact-GEF/diff 0 0.001 0.001 \ "" white black 829.45 9.352 0 simundump kpool /kinetics/chain/kinetics[16]/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 822.45 5.246 0 simundump kenz /kinetics/chain/kinetics[16]/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 \ 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 823.09 4.086 0 simundump kreac /kinetics/chain/kinetics[16]/Ras/GEF*/diff 0 0.001 0.001 "" \ white black 823.45 8.246 0 simundump kpool /kinetics/chain/kinetics[16]/Ras/GTP-Ras 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange blue 828.56 1.084 0 simundump kpool /kinetics/chain/kinetics[16]/Ras/GDP-Ras 1 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink blue 822.13 2.165 0 simundump kreac /kinetics/chain/kinetics[16]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 825.1 1.5 0 simundump kreac /kinetics/chain/kinetics[16]/Ras/dephosph-GAP 1 0.1 0 "" \ white blue 820.02 3.524 0 simundump kpool /kinetics/chain/kinetics[16]/Ras/GAP* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red blue 817.35 2.349 0 simundump kreac /kinetics/chain/kinetics[16]/Ras/GAP*/diff 0 0.001 0.001 "" \ white black 818.35 5.349 0 simundump kpool /kinetics/chain/kinetics[16]/Ras/GAP 1 -1e-12 0.01 0.01 \ 753.96 753.96 0 0 75396 0 /kinetics/dendgeom red blue 822.66 0.338 0 simundump kenz /kinetics/chain/kinetics[16]/Ras/GAP/GAP-inact-ras 1 0 0 0 0 \ 75396 0.00065634 40 10 0 0 "" red red "" 825.01 0.403 0 simundump kreac /kinetics/chain/kinetics[16]/Ras/GAP/diff 0 0.001 0.001 "" \ white black 823.66 3.338 0 simundump kreac /kinetics/chain/kinetics[16]/Ras/CaM-bind-GEF 1 0.0026526 1 \ "" white blue 818.49 9.679 0 simundump kpool /kinetics/chain/kinetics[16]/Ras/CaM-GEF 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 821.34 7.58 0 simundump kenz /kinetics/chain/kinetics[16]/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 \ 0 0 75396 1.3131e-05 0.4 0.1 0 0 "" red pink "" 821.02 6.657 0 simundump kreac /kinetics/chain/kinetics[16]/Ras/CaM-GEF/diff 0 0.001 0.001 \ "" white black 822.34 10.58 0 simundump kpool /kinetics/chain/kinetics[16]/Ca 1 -1e-12 0.095 0.095 7162.6 \ 7162.6 0 0 75396 4 /kinetics/dendgeom red black 801 -13 0 simundump kpool /kinetics/chain/kinetics[16]/DAG 1 -1e-12 12.2 12.2 \ 9.1983e+05 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 816.72 \ -19.562 0 simundump kpool /kinetics/chain/kinetics[16]/PKC-active 1 -1e-12 0.3 \ 2.1196e-16 1.5981e-11 22619 0 0 75396 2 /kinetics/dendgeom red black 816 -3 \ 0 simundump kenz /kinetics/chain/kinetics[16]/PKC-active/PKC-act-raf 1 0 0 0 0 \ 75396 3.979e-06 16 4 0 0 "" red yellow "" 822 -2 0 simundump kenz /kinetics/chain/kinetics[16]/PKC-active/PKC-inact-GAP 1 0 0 0 \ 0 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 820 1 0 simundump kenz /kinetics/chain/kinetics[16]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 825 8 0 simundump kenz /kinetics/chain/kinetics[16]/PKC-active/phosph-AC2 1 0 0 0 0 \ 75396 0.00066667 16 4 0 0 "" red red "" 809.32 -23.269 0 simundump kpool /kinetics/chain/kinetics[16]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 829 -11 0 simundump kenz /kinetics/chain/kinetics[16]/MAPK*/MAPK* 0 0 0 0 0 75396 \ 2.5864e-05 40 10 0 0 "" red orange "" 804 -26 0 simundump kenz /kinetics/chain/kinetics[16]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange "" 826 -2 0 simundump kreac /kinetics/chain/kinetics[16]/MAPK*/diff 0 0.001 0.001 "" \ white black 830 -8 0 simundump kpool /kinetics/chain/kinetics[16]/IP3 1 -1e-12 0.73 0.73 55039 \ 55039 0 0 75396 4 /kinetics/dendgeom pink black 815.23 -16.656 0 simundump kpool /kinetics/chain/kinetics[16]/MKP-1 1 -1e-12 0.024 0.024 \ 1809.5 1809.5 0 0 75396 0 /kinetics/dendgeom hotpink black 821 -10 0 simundump kenz /kinetics/chain/kinetics[16]/MKP-1/MKP1-tyr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 822 -9 0 simundump kenz /kinetics/chain/kinetics[16]/MKP-1/MKP1-thr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 827 -9 0 simundump kreac /kinetics/chain/kinetics[16]/MKP-1/diff 0 0.001 0.001 "" \ white black 822 -7 0 simundump kpool /kinetics/chain/kinetics[16]/PPhosphatase2A 1 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom hotpink yellow 825 -3 0 simundump kenz /kinetics/chain/kinetics[16]/PPhosphatase2A/craf-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 824 -2 0 simundump kenz /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 827 -5 0 simundump kenz /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph-ser 1 0 \ 0 0 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 824 -5 0 simundump kenz /kinetics/chain/kinetics[16]/PPhosphatase2A/craf**-deph 1 0 0 \ 0 0 0.12566 2.5414e-05 24 6 0 0 "" red hotpink "" 828 -2 0 simundump kreac /kinetics/chain/kinetics[16]/PPhosphatase2A/diff 0 0.001 \ 0.001 "" white black 826 0 0 simundump group /kinetics/chain/kinetics[16]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 803 -9 0 simundump kpool /kinetics/chain/kinetics[16]/CaM/CaM 1 -1e-12 20 20 \ 1.5079e+06 1.5079e+06 0 0 75396 0 /kinetics/dendgeom pink blue 802.98 -1.28 \ 0 simundump kreac /kinetics/chain/kinetics[16]/CaM/CaM/diff 0 0.001 0.001 "" \ white black 803.98 1.72 0 simundump kreac /kinetics/chain/kinetics[16]/CaM/CaM-TR2-bind-Ca 1 1.2666e-08 \ 72 "" white blue 805.16 -1.921 0 simundump kreac /kinetics/chain/kinetics[16]/CaM/CaM-TR2-Ca2-bind-Ca 1 \ 4.7748e-05 10 "" white blue 804.16 -3.7747 0 simundump kreac /kinetics/chain/kinetics[16]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 802.6 -6.7404 0 simundump kpool /kinetics/chain/kinetics[16]/CaM/CaM-Ca3 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 806.49 -5.603 0 simundump kreac /kinetics/chain/kinetics[16]/CaM/CaM-Ca3/diff 0 0.001 0.001 \ "" white black 807.49 -2.603 0 simundump kpool /kinetics/chain/kinetics[16]/CaM/CaM-TR2-Ca2 1 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 808 -2.7423 0 simundump kreac /kinetics/chain/kinetics[16]/CaM/CaM-TR2-Ca2/diff 0 0.001 \ 0.001 "" white black 809 0.2577 0 simundump kpool /kinetics/chain/kinetics[16]/CaM/CaM-Ca4 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom blue blue 808 -8 0 simundump kreac /kinetics/chain/kinetics[16]/CaM/CaM-Ca4/diff 0 0.001 0.001 \ "" white black 809 -5 0 simundump kreac /kinetics/chain/kinetics[16]/Ras-act-unphosph-raf 0 7.958e-05 \ 1 "" white black 820 -4 0 simundump kpool /kinetics/chain/kinetics[16]/Ca_input 0 -1e-12 0.08 0.08 \ 6031.7 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 794 -7 0 simundump kreac /kinetics/chain/kinetics[16]/Ca_diff 0 2 2 "" white black 795 \ -12 0 simundump group /kinetics/chain/kinetics[17] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 854 0 0 simundump group /kinetics/chain/kinetics[17]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 862.95 -3.7837 0 simundump kpool /kinetics/chain/kinetics[17]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 861.92 -10.489 0 simundump kreac /kinetics/chain/kinetics[17]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 862.92 -7.489 0 simundump kreac /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 861.92 -12.123 0 simundump kreac /kinetics/chain/kinetics[17]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 863.94 -11.306 0 simundump kreac /kinetics/chain/kinetics[17]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 862.2 -7.7467 0 simundump kreac /kinetics/chain/kinetics[17]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 863.38 -9.2638 0 simundump kreac /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca-AA 0 \ 1.5916e-08 0.1 "" white blue 865.21 -8.1843 0 simundump kreac /kinetics/chain/kinetics[17]/PKC/PKC-act-by-DAG-AA 0 2 0.2 "" \ white blue 867.25 -8.7678 0 simundump kpool /kinetics/chain/kinetics[17]/PKC/PKC-DAG-AA* 0 -1e-12 \ 4.9137e-18 4.9137e-18 3.7047e-13 3.7047e-13 0 0 75396 0 /kinetics/dendgeom \ cyan blue 866.6 -6.463 0 simundump kreac /kinetics/chain/kinetics[17]/PKC/PKC-DAG-AA*/diff 0 0.001 \ 0.001 "" white black 867.6 -3.463 0 simundump kpool /kinetics/chain/kinetics[17]/PKC/PKC-Ca-AA* 0 -1e-12 \ 1.7501e-16 1.7501e-16 1.3195e-11 1.3195e-11 0 0 75396 0 /kinetics/dendgeom \ orange blue 865.4 -5.7044 0 simundump kreac /kinetics/chain/kinetics[17]/PKC/PKC-Ca-AA*/diff 0 0.001 \ 0.001 "" white black 866.4 -2.7044 0 simundump kpool /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb* 0 -1e-12 \ 1.3896e-17 1.3896e-17 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom \ pink blue 863.22 -5.471 0 simundump kreac /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb*/diff 0 0.001 \ 0.001 "" white black 864.22 -2.471 0 simundump kpool /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb* 0 -1e-12 \ 9.4351e-21 9.4351e-21 7.1137e-16 7.1137e-16 0 0 75396 0 /kinetics/dendgeom \ yellow blue 864.17 -6.4922 0 simundump kreac /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb*/diff 0 0.001 \ 0.001 "" white black 865.17 -3.4922 0 simundump kpool /kinetics/chain/kinetics[17]/PKC/PKC-basal* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 861.25 -6.4338 0 simundump kreac /kinetics/chain/kinetics[17]/PKC/PKC-basal*/diff 0 0.001 \ 0.001 "" white black 862.25 -3.4338 0 simundump kreac /kinetics/chain/kinetics[17]/PKC/PKC-basal-act 0 1 50 "" \ white blue 861.02 -8.9429 0 simundump kpool /kinetics/chain/kinetics[17]/PKC/PKC-AA* 0 -1e-12 1.8134e-17 \ 1.8134e-17 1.3672e-12 1.3672e-12 0 0 75396 0 /kinetics/dendgeom cyan blue \ 867.78 -5.1793 0 simundump kreac /kinetics/chain/kinetics[17]/PKC/PKC-AA*/diff 0 0.001 0.001 \ "" white black 868.78 -2.1793 0 simundump kreac /kinetics/chain/kinetics[17]/PKC/PKC-act-by-AA 0 1.5916e-09 \ 0.1 "" white blue 861.01 -13.865 0 simundump kpool /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG 0 -1e-12 \ 8.4632e-23 8.4632e-23 6.3809e-18 6.3809e-18 0 0 75396 0 /kinetics/dendgeom \ white blue 866.23 -10.197 0 simundump kreac /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG/diff 0 0.001 \ 0.001 "" white black 867.23 -7.197 0 simundump kreac /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 862.99 -13.99 0 simundump kpool /kinetics/chain/kinetics[17]/PKC/PKC-DAG 0 -1e-12 1.161e-16 \ 1.161e-16 8.7535e-12 8.7535e-12 0 0 75396 0 /kinetics/dendgeom white blue \ 865 -13.086 0 simundump kreac /kinetics/chain/kinetics[17]/PKC/PKC-DAG/diff 0 0.001 0.001 \ "" white black 866 -10.086 0 simundump kreac /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG-AA 0 2.3874e-07 2 \ "" white blue 864.77 -14.953 0 simundump kpool /kinetics/chain/kinetics[17]/PKC/PKC-DAG-AA 0 -1e-12 \ 2.5188e-19 2.5188e-19 1.8991e-14 1.8991e-14 0 0 75396 0 /kinetics/dendgeom \ white blue 866.62 -11.773 0 simundump kreac /kinetics/chain/kinetics[17]/PKC/PKC-DAG-AA/diff 0 0.001 \ 0.001 "" white black 867.62 -8.773 0 simundump kpool /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic 0 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom white blue 859.87 -11.403 0 simundump kreac /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic/diff 0 0.001 \ 0.001 "" white black 860.87 -8.403 0 simundump kpool /kinetics/chain/kinetics[17]/AA 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom darkgreen black 862.71 -21.338 0 simundump kreac /kinetics/chain/kinetics[17]/AA/diff 0 0.001 0.001 "" white \ black 863.71 -18.338 0 simundump group /kinetics/chain/kinetics[17]/PLA2 0 darkgreen black x 0 1 "" \ defaultfile defaultfile.g 0 0 0 858.64 -26.209 0 simundump kpool /kinetics/chain/kinetics[17]/PLA2/PLA2-cytosolic 0 -1e-12 \ 0.39999 0.39999 30158 30158 0 0 75396 0 /kinetics/dendgeom yellow darkgreen \ 854.18 -20.942 0 simundump kreac /kinetics/chain/kinetics[17]/PLA2/PLA2-cytosolic/diff 0 0.001 \ 0.001 "" white black 855.18 -17.942 0 simundump kreac /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca-act 0 1.3263e-05 \ 0.1 "" white darkgreen 854.9 -23.104 0 simundump kpool /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom yellow darkgreen 857.28 -23.646 0 simundump kenz /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca*/kenz 0 0 0 0 0 \ 75396 1.7906e-05 21.6 5.4 0 0 "" red yellow "" 859.94 -23.667 0 simundump kreac /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca*/diff 0 0.001 0.001 \ "" white black 858.28 -20.646 0 simundump kreac /kinetics/chain/kinetics[17]/PLA2/PIP2-PLA2-act 0 1.5916e-08 \ 0.5 "" white darkgreen 854.95 -18.75 0 simundump kpool /kinetics/chain/kinetics[17]/PLA2/PIP2-PLA2* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 857.32 -18.292 0 simundump kenz /kinetics/chain/kinetics[17]/PLA2/PIP2-PLA2*/kenz 0 0 0 0 0 \ 75396 3.6607e-05 44.16 11.04 0 0 "" red cyan "" 859.97 -18.271 0 simundump kreac /kinetics/chain/kinetics[17]/PLA2/PIP2-PLA2*/diff 0 0.001 \ 0.001 "" white black 858.32 -15.292 0 simundump kreac /kinetics/chain/kinetics[17]/PLA2/PIP2-Ca-PLA2-act 0 \ 1.5916e-07 0.1 "" white darkgreen 855.9 -19.5 0 simundump kpool /kinetics/chain/kinetics[17]/PLA2/PIP2-Ca-PLA2* 0 -1e-12 0 0 \ 0 0 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 857.67 -19.896 0 simundump kenz /kinetics/chain/kinetics[17]/PLA2/PIP2-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00011937 144 36 0 0 "" red cyan "" 860.03 -19.979 0 simundump kreac /kinetics/chain/kinetics[17]/PLA2/PIP2-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 858.67 -16.896 0 simundump kreac /kinetics/chain/kinetics[17]/PLA2/DAG-Ca-PLA2-act 0 3.979e-08 \ 4 "" white darkgreen 855.17 -21.834 0 simundump kpool /kinetics/chain/kinetics[17]/PLA2/DAG-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom pink darkgreen 857.86 -22.479 0 simundump kenz /kinetics/chain/kinetics[17]/PLA2/DAG-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00019895 240 60 0 0 "" red pink "" 860.05 -22.354 0 simundump kreac /kinetics/chain/kinetics[17]/PLA2/DAG-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 858.86 -19.479 0 simundump kpool /kinetics/chain/kinetics[17]/PLA2/APC 0 -1e-12 30 30 \ 2.2619e+06 2.2619e+06 0 0 75396 4 /kinetics/dendgeom yellow darkgreen \ 857.76 -21.963 0 simundump kreac /kinetics/chain/kinetics[17]/PLA2/Degrade-AA 1 0.4 0 "" white \ darkgreen 859.82 -17.288 0 simundump kpool /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange darkgreen 858.19 -24.687 0 simundump kenz /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca/kenz 0 0 0 0 0 \ 75396 0.0003979 480 120 0 0 "" red orange "" 859.92 -24.817 0 simundump kreac /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca/diff 0 0.001 0.001 \ "" white black 859.19 -21.687 0 simundump kpool /kinetics/chain/kinetics[17]/PLA2/PLA2* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange darkgreen 856.97 -26.851 0 simundump kreac /kinetics/chain/kinetics[17]/PLA2/PLA2*/diff 0 0.001 0.001 "" \ white black 857.97 -23.851 0 simundump kreac /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca-act 1 7.958e-05 \ 0.1 "" white darkgreen 855.91 -24.752 0 simundump kreac /kinetics/chain/kinetics[17]/PLA2/dephosphorylate-PLA2* 1 \ 0.17 0 "" white darkgreen 852.31 -23.735 0 simundump kpool /kinetics/chain/kinetics[17]/temp-PIP2 1 -1e-12 2.5 2.5 \ 1.8849e+05 1.8849e+05 0 0 75396 4 /kinetics/dendgeom green black 850.2 \ -19.047 0 simundump group /kinetics/chain/kinetics[17]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 881 -1 0 simundump kpool /kinetics/chain/kinetics[17]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 872 -4 0 simundump kpool /kinetics/chain/kinetics[17]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 875 -4 0 simundump kpool /kinetics/chain/kinetics[17]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 872 -8 0 simundump kpool /kinetics/chain/kinetics[17]/MAPK/MAPK 0 -1e-12 3.5999 3.5999 \ 2.7142e+05 2.7142e+05 0 0 75396 0 /kinetics/dendgeom pink brown 872 -11 0 simundump kreac /kinetics/chain/kinetics[17]/MAPK/MAPK/diff 0 0.001 0.001 "" \ white black 873 -8 0 simundump kpool /kinetics/chain/kinetics[17]/MAPK/craf-1** 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink brown 878 -4 0 simundump kpool /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr 1 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange brown 875 -11 0 simundump kreac /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr/diff 0 0.001 0.001 \ "" white black 876 -8 0 simundump kpool /kinetics/chain/kinetics[17]/MAPK/MAPKK* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 879 -8 0 simundump kenz /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 874 -9 0 simundump kenz /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 879 -9 0 simundump kpool /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 875 -8 0 simundump kpool /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 871 -6 0 simundump kenz /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 874 -6 0 simundump kenz /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 877 -6 0 simundump kpool /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom red brown 871 -7 0 simundump kenz /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 874 -7 0 simundump kenz /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 877 -7 0 simundump kreac /kinetics/chain/kinetics[17]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 869 -3 0 simundump group /kinetics/chain/kinetics[17]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 880.51 4.351 0 simundump kreac /kinetics/chain/kinetics[17]/Ras/dephosph-GEF 1 1 0 "" white \ blue 875.07 5.881 0 simundump kpool /kinetics/chain/kinetics[17]/Ras/inact-GEF 1 -1e-12 0.1 0.1 \ 7539.6 7539.6 0 0 75396 0 /kinetics/dendgeom hotpink blue 878.45 6.352 0 simundump kenz /kinetics/chain/kinetics[17]/Ras/inact-GEF/basal_GEF_activity 0 \ 0 0 0 0 75396 1.313e-07 0.08 0.02 0 0 "" red hotpink "" 877 5 0 simundump kreac /kinetics/chain/kinetics[17]/Ras/inact-GEF/diff 0 0.001 0.001 \ "" white black 879.45 9.352 0 simundump kpool /kinetics/chain/kinetics[17]/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 872.45 5.246 0 simundump kenz /kinetics/chain/kinetics[17]/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 \ 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 873.09 4.086 0 simundump kreac /kinetics/chain/kinetics[17]/Ras/GEF*/diff 0 0.001 0.001 "" \ white black 873.45 8.246 0 simundump kpool /kinetics/chain/kinetics[17]/Ras/GTP-Ras 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange blue 878.56 1.084 0 simundump kpool /kinetics/chain/kinetics[17]/Ras/GDP-Ras 1 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink blue 872.13 2.165 0 simundump kreac /kinetics/chain/kinetics[17]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 875.1 1.5 0 simundump kreac /kinetics/chain/kinetics[17]/Ras/dephosph-GAP 1 0.1 0 "" \ white blue 870.02 3.524 0 simundump kpool /kinetics/chain/kinetics[17]/Ras/GAP* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red blue 867.35 2.349 0 simundump kreac /kinetics/chain/kinetics[17]/Ras/GAP*/diff 0 0.001 0.001 "" \ white black 868.35 5.349 0 simundump kpool /kinetics/chain/kinetics[17]/Ras/GAP 1 -1e-12 0.01 0.01 \ 753.96 753.96 0 0 75396 0 /kinetics/dendgeom red blue 872.66 0.338 0 simundump kenz /kinetics/chain/kinetics[17]/Ras/GAP/GAP-inact-ras 1 0 0 0 0 \ 75396 0.00065634 40 10 0 0 "" red red "" 875.01 0.403 0 simundump kreac /kinetics/chain/kinetics[17]/Ras/GAP/diff 0 0.001 0.001 "" \ white black 873.66 3.338 0 simundump kreac /kinetics/chain/kinetics[17]/Ras/CaM-bind-GEF 1 0.0026526 1 \ "" white blue 868.49 9.679 0 simundump kpool /kinetics/chain/kinetics[17]/Ras/CaM-GEF 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 871.34 7.58 0 simundump kenz /kinetics/chain/kinetics[17]/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 \ 0 0 75396 1.3131e-05 0.4 0.1 0 0 "" red pink "" 871.02 6.657 0 simundump kreac /kinetics/chain/kinetics[17]/Ras/CaM-GEF/diff 0 0.001 0.001 \ "" white black 872.34 10.58 0 simundump kpool /kinetics/chain/kinetics[17]/Ca 1 -1e-12 0.095 0.095 7162.6 \ 7162.6 0 0 75396 4 /kinetics/dendgeom red black 851 -13 0 simundump kpool /kinetics/chain/kinetics[17]/DAG 1 -1e-12 12.2 12.2 \ 9.1983e+05 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 866.72 \ -19.562 0 simundump kpool /kinetics/chain/kinetics[17]/PKC-active 1 -1e-12 0.3 \ 2.1196e-16 1.5981e-11 22619 0 0 75396 2 /kinetics/dendgeom red black 866 -3 \ 0 simundump kenz /kinetics/chain/kinetics[17]/PKC-active/PKC-act-raf 1 0 0 0 0 \ 75396 3.979e-06 16 4 0 0 "" red yellow "" 872 -2 0 simundump kenz /kinetics/chain/kinetics[17]/PKC-active/PKC-inact-GAP 1 0 0 0 \ 0 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 870 1 0 simundump kenz /kinetics/chain/kinetics[17]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 875 8 0 simundump kenz /kinetics/chain/kinetics[17]/PKC-active/phosph-AC2 1 0 0 0 0 \ 75396 0.00066667 16 4 0 0 "" red red "" 859.32 -23.269 0 simundump kpool /kinetics/chain/kinetics[17]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 879 -11 0 simundump kenz /kinetics/chain/kinetics[17]/MAPK*/MAPK* 0 0 0 0 0 75396 \ 2.5864e-05 40 10 0 0 "" red orange "" 854 -26 0 simundump kenz /kinetics/chain/kinetics[17]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange "" 876 -2 0 simundump kreac /kinetics/chain/kinetics[17]/MAPK*/diff 0 0.001 0.001 "" \ white black 880 -8 0 simundump kpool /kinetics/chain/kinetics[17]/IP3 1 -1e-12 0.73 0.73 55039 \ 55039 0 0 75396 4 /kinetics/dendgeom pink black 865.23 -16.656 0 simundump kpool /kinetics/chain/kinetics[17]/MKP-1 1 -1e-12 0.024 0.024 \ 1809.5 1809.5 0 0 75396 0 /kinetics/dendgeom hotpink black 871 -10 0 simundump kenz /kinetics/chain/kinetics[17]/MKP-1/MKP1-tyr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 872 -9 0 simundump kenz /kinetics/chain/kinetics[17]/MKP-1/MKP1-thr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 877 -9 0 simundump kreac /kinetics/chain/kinetics[17]/MKP-1/diff 0 0.001 0.001 "" \ white black 872 -7 0 simundump kpool /kinetics/chain/kinetics[17]/PPhosphatase2A 1 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom hotpink yellow 875 -3 0 simundump kenz /kinetics/chain/kinetics[17]/PPhosphatase2A/craf-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 874 -2 0 simundump kenz /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 877 -5 0 simundump kenz /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph-ser 1 0 \ 0 0 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 874 -5 0 simundump kenz /kinetics/chain/kinetics[17]/PPhosphatase2A/craf**-deph 1 0 0 \ 0 0 0.12566 2.5414e-05 24 6 0 0 "" red hotpink "" 878 -2 0 simundump kreac /kinetics/chain/kinetics[17]/PPhosphatase2A/diff 0 0.001 \ 0.001 "" white black 876 0 0 simundump group /kinetics/chain/kinetics[17]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 853 -9 0 simundump kpool /kinetics/chain/kinetics[17]/CaM/CaM 1 -1e-12 20 20 \ 1.5079e+06 1.5079e+06 0 0 75396 0 /kinetics/dendgeom pink blue 852.98 -1.28 \ 0 simundump kreac /kinetics/chain/kinetics[17]/CaM/CaM/diff 0 0.001 0.001 "" \ white black 853.98 1.72 0 simundump kreac /kinetics/chain/kinetics[17]/CaM/CaM-TR2-bind-Ca 1 1.2666e-08 \ 72 "" white blue 855.16 -1.921 0 simundump kreac /kinetics/chain/kinetics[17]/CaM/CaM-TR2-Ca2-bind-Ca 1 \ 4.7748e-05 10 "" white blue 854.16 -3.7747 0 simundump kreac /kinetics/chain/kinetics[17]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 852.6 -6.7404 0 simundump kpool /kinetics/chain/kinetics[17]/CaM/CaM-Ca3 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 856.49 -5.603 0 simundump kreac /kinetics/chain/kinetics[17]/CaM/CaM-Ca3/diff 0 0.001 0.001 \ "" white black 857.49 -2.603 0 simundump kpool /kinetics/chain/kinetics[17]/CaM/CaM-TR2-Ca2 1 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 858 -2.7423 0 simundump kreac /kinetics/chain/kinetics[17]/CaM/CaM-TR2-Ca2/diff 0 0.001 \ 0.001 "" white black 859 0.2577 0 simundump kpool /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom blue blue 858 -8 0 simundump kreac /kinetics/chain/kinetics[17]/CaM/CaM-Ca4/diff 0 0.001 0.001 \ "" white black 859 -5 0 simundump kreac /kinetics/chain/kinetics[17]/Ras-act-unphosph-raf 0 7.958e-05 \ 1 "" white black 870 -4 0 simundump kpool /kinetics/chain/kinetics[17]/Ca_input 0 -1e-12 0.08 0.08 \ 6031.7 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 844 -7 0 simundump kreac /kinetics/chain/kinetics[17]/Ca_diff 0 2 2 "" white black 845 \ -12 0 simundump group /kinetics/chain/kinetics[18] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 904 0 0 simundump group /kinetics/chain/kinetics[18]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 912.95 -3.7837 0 simundump kpool /kinetics/chain/kinetics[18]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 911.92 -10.489 0 simundump kreac /kinetics/chain/kinetics[18]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 912.92 -7.489 0 simundump kreac /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 911.92 -12.123 0 simundump kreac /kinetics/chain/kinetics[18]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 913.94 -11.306 0 simundump kreac /kinetics/chain/kinetics[18]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 912.2 -7.7467 0 simundump kreac /kinetics/chain/kinetics[18]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 913.38 -9.2638 0 simundump kreac /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca-AA 0 \ 1.5916e-08 0.1 "" white blue 915.21 -8.1843 0 simundump kreac /kinetics/chain/kinetics[18]/PKC/PKC-act-by-DAG-AA 0 2 0.2 "" \ white blue 917.25 -8.7678 0 simundump kpool /kinetics/chain/kinetics[18]/PKC/PKC-DAG-AA* 0 -1e-12 \ 4.9137e-18 4.9137e-18 3.7047e-13 3.7047e-13 0 0 75396 0 /kinetics/dendgeom \ cyan blue 916.6 -6.463 0 simundump kreac /kinetics/chain/kinetics[18]/PKC/PKC-DAG-AA*/diff 0 0.001 \ 0.001 "" white black 917.6 -3.463 0 simundump kpool /kinetics/chain/kinetics[18]/PKC/PKC-Ca-AA* 0 -1e-12 \ 1.7501e-16 1.7501e-16 1.3195e-11 1.3195e-11 0 0 75396 0 /kinetics/dendgeom \ orange blue 915.4 -5.7044 0 simundump kreac /kinetics/chain/kinetics[18]/PKC/PKC-Ca-AA*/diff 0 0.001 \ 0.001 "" white black 916.4 -2.7044 0 simundump kpool /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb* 0 -1e-12 \ 1.3896e-17 1.3896e-17 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom \ pink blue 913.22 -5.471 0 simundump kreac /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb*/diff 0 0.001 \ 0.001 "" white black 914.22 -2.471 0 simundump kpool /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb* 0 -1e-12 \ 9.4351e-21 9.4351e-21 7.1137e-16 7.1137e-16 0 0 75396 0 /kinetics/dendgeom \ yellow blue 914.17 -6.4922 0 simundump kreac /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb*/diff 0 0.001 \ 0.001 "" white black 915.17 -3.4922 0 simundump kpool /kinetics/chain/kinetics[18]/PKC/PKC-basal* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 911.25 -6.4338 0 simundump kreac /kinetics/chain/kinetics[18]/PKC/PKC-basal*/diff 0 0.001 \ 0.001 "" white black 912.25 -3.4338 0 simundump kreac /kinetics/chain/kinetics[18]/PKC/PKC-basal-act 0 1 50 "" \ white blue 911.02 -8.9429 0 simundump kpool /kinetics/chain/kinetics[18]/PKC/PKC-AA* 0 -1e-12 1.8134e-17 \ 1.8134e-17 1.3672e-12 1.3672e-12 0 0 75396 0 /kinetics/dendgeom cyan blue \ 917.78 -5.1793 0 simundump kreac /kinetics/chain/kinetics[18]/PKC/PKC-AA*/diff 0 0.001 0.001 \ "" white black 918.78 -2.1793 0 simundump kreac /kinetics/chain/kinetics[18]/PKC/PKC-act-by-AA 0 1.5916e-09 \ 0.1 "" white blue 911.01 -13.865 0 simundump kpool /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG 0 -1e-12 \ 8.4632e-23 8.4632e-23 6.3809e-18 6.3809e-18 0 0 75396 0 /kinetics/dendgeom \ white blue 916.23 -10.197 0 simundump kreac /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG/diff 0 0.001 \ 0.001 "" white black 917.23 -7.197 0 simundump kreac /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 912.99 -13.99 0 simundump kpool /kinetics/chain/kinetics[18]/PKC/PKC-DAG 0 -1e-12 1.161e-16 \ 1.161e-16 8.7535e-12 8.7535e-12 0 0 75396 0 /kinetics/dendgeom white blue \ 915 -13.086 0 simundump kreac /kinetics/chain/kinetics[18]/PKC/PKC-DAG/diff 0 0.001 0.001 \ "" white black 916 -10.086 0 simundump kreac /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG-AA 0 2.3874e-07 2 \ "" white blue 914.77 -14.953 0 simundump kpool /kinetics/chain/kinetics[18]/PKC/PKC-DAG-AA 0 -1e-12 \ 2.5188e-19 2.5188e-19 1.8991e-14 1.8991e-14 0 0 75396 0 /kinetics/dendgeom \ white blue 916.62 -11.773 0 simundump kreac /kinetics/chain/kinetics[18]/PKC/PKC-DAG-AA/diff 0 0.001 \ 0.001 "" white black 917.62 -8.773 0 simundump kpool /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic 0 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom white blue 909.87 -11.403 0 simundump kreac /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic/diff 0 0.001 \ 0.001 "" white black 910.87 -8.403 0 simundump kpool /kinetics/chain/kinetics[18]/AA 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom darkgreen black 912.71 -21.338 0 simundump kreac /kinetics/chain/kinetics[18]/AA/diff 0 0.001 0.001 "" white \ black 913.71 -18.338 0 simundump group /kinetics/chain/kinetics[18]/PLA2 0 darkgreen black x 0 1 "" \ defaultfile defaultfile.g 0 0 0 908.64 -26.209 0 simundump kpool /kinetics/chain/kinetics[18]/PLA2/PLA2-cytosolic 0 -1e-12 \ 0.39999 0.39999 30158 30158 0 0 75396 0 /kinetics/dendgeom yellow darkgreen \ 904.18 -20.942 0 simundump kreac /kinetics/chain/kinetics[18]/PLA2/PLA2-cytosolic/diff 0 0.001 \ 0.001 "" white black 905.18 -17.942 0 simundump kreac /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca-act 0 1.3263e-05 \ 0.1 "" white darkgreen 904.9 -23.104 0 simundump kpool /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom yellow darkgreen 907.28 -23.646 0 simundump kenz /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca*/kenz 0 0 0 0 0 \ 75396 1.7906e-05 21.6 5.4 0 0 "" red yellow "" 909.94 -23.667 0 simundump kreac /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca*/diff 0 0.001 0.001 \ "" white black 908.28 -20.646 0 simundump kreac /kinetics/chain/kinetics[18]/PLA2/PIP2-PLA2-act 0 1.5916e-08 \ 0.5 "" white darkgreen 904.95 -18.75 0 simundump kpool /kinetics/chain/kinetics[18]/PLA2/PIP2-PLA2* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 907.32 -18.292 0 simundump kenz /kinetics/chain/kinetics[18]/PLA2/PIP2-PLA2*/kenz 0 0 0 0 0 \ 75396 3.6607e-05 44.16 11.04 0 0 "" red cyan "" 909.97 -18.271 0 simundump kreac /kinetics/chain/kinetics[18]/PLA2/PIP2-PLA2*/diff 0 0.001 \ 0.001 "" white black 908.32 -15.292 0 simundump kreac /kinetics/chain/kinetics[18]/PLA2/PIP2-Ca-PLA2-act 0 \ 1.5916e-07 0.1 "" white darkgreen 905.9 -19.5 0 simundump kpool /kinetics/chain/kinetics[18]/PLA2/PIP2-Ca-PLA2* 0 -1e-12 0 0 \ 0 0 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 907.67 -19.896 0 simundump kenz /kinetics/chain/kinetics[18]/PLA2/PIP2-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00011937 144 36 0 0 "" red cyan "" 910.03 -19.979 0 simundump kreac /kinetics/chain/kinetics[18]/PLA2/PIP2-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 908.67 -16.896 0 simundump kreac /kinetics/chain/kinetics[18]/PLA2/DAG-Ca-PLA2-act 0 3.979e-08 \ 4 "" white darkgreen 905.17 -21.834 0 simundump kpool /kinetics/chain/kinetics[18]/PLA2/DAG-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom pink darkgreen 907.86 -22.479 0 simundump kenz /kinetics/chain/kinetics[18]/PLA2/DAG-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00019895 240 60 0 0 "" red pink "" 910.05 -22.354 0 simundump kreac /kinetics/chain/kinetics[18]/PLA2/DAG-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 908.86 -19.479 0 simundump kpool /kinetics/chain/kinetics[18]/PLA2/APC 0 -1e-12 30 30 \ 2.2619e+06 2.2619e+06 0 0 75396 4 /kinetics/dendgeom yellow darkgreen \ 907.76 -21.963 0 simundump kreac /kinetics/chain/kinetics[18]/PLA2/Degrade-AA 1 0.4 0 "" white \ darkgreen 909.82 -17.288 0 simundump kpool /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange darkgreen 908.19 -24.687 0 simundump kenz /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca/kenz 0 0 0 0 0 \ 75396 0.0003979 480 120 0 0 "" red orange "" 909.92 -24.817 0 simundump kreac /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca/diff 0 0.001 0.001 \ "" white black 909.19 -21.687 0 simundump kpool /kinetics/chain/kinetics[18]/PLA2/PLA2* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange darkgreen 906.97 -26.851 0 simundump kreac /kinetics/chain/kinetics[18]/PLA2/PLA2*/diff 0 0.001 0.001 "" \ white black 907.97 -23.851 0 simundump kreac /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca-act 1 7.958e-05 \ 0.1 "" white darkgreen 905.91 -24.752 0 simundump kreac /kinetics/chain/kinetics[18]/PLA2/dephosphorylate-PLA2* 1 \ 0.17 0 "" white darkgreen 902.31 -23.735 0 simundump kpool /kinetics/chain/kinetics[18]/temp-PIP2 1 -1e-12 2.5 2.5 \ 1.8849e+05 1.8849e+05 0 0 75396 4 /kinetics/dendgeom green black 900.2 \ -19.047 0 simundump group /kinetics/chain/kinetics[18]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 931 -1 0 simundump kpool /kinetics/chain/kinetics[18]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 922 -4 0 simundump kpool /kinetics/chain/kinetics[18]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 925 -4 0 simundump kpool /kinetics/chain/kinetics[18]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 922 -8 0 simundump kpool /kinetics/chain/kinetics[18]/MAPK/MAPK 0 -1e-12 3.5999 3.5999 \ 2.7142e+05 2.7142e+05 0 0 75396 0 /kinetics/dendgeom pink brown 922 -11 0 simundump kreac /kinetics/chain/kinetics[18]/MAPK/MAPK/diff 0 0.001 0.001 "" \ white black 923 -8 0 simundump kpool /kinetics/chain/kinetics[18]/MAPK/craf-1** 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink brown 928 -4 0 simundump kpool /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr 1 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange brown 925 -11 0 simundump kreac /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr/diff 0 0.001 0.001 \ "" white black 926 -8 0 simundump kpool /kinetics/chain/kinetics[18]/MAPK/MAPKK* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 929 -8 0 simundump kenz /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 924 -9 0 simundump kenz /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 929 -9 0 simundump kpool /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 925 -8 0 simundump kpool /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 921 -6 0 simundump kenz /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 924 -6 0 simundump kenz /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 927 -6 0 simundump kpool /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom red brown 921 -7 0 simundump kenz /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 924 -7 0 simundump kenz /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 927 -7 0 simundump kreac /kinetics/chain/kinetics[18]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 919 -3 0 simundump group /kinetics/chain/kinetics[18]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 930.51 4.351 0 simundump kreac /kinetics/chain/kinetics[18]/Ras/dephosph-GEF 1 1 0 "" white \ blue 925.07 5.881 0 simundump kpool /kinetics/chain/kinetics[18]/Ras/inact-GEF 1 -1e-12 0.1 0.1 \ 7539.6 7539.6 0 0 75396 0 /kinetics/dendgeom hotpink blue 928.45 6.352 0 simundump kenz /kinetics/chain/kinetics[18]/Ras/inact-GEF/basal_GEF_activity 0 \ 0 0 0 0 75396 1.313e-07 0.08 0.02 0 0 "" red hotpink "" 927 5 0 simundump kreac /kinetics/chain/kinetics[18]/Ras/inact-GEF/diff 0 0.001 0.001 \ "" white black 929.45 9.352 0 simundump kpool /kinetics/chain/kinetics[18]/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 922.45 5.246 0 simundump kenz /kinetics/chain/kinetics[18]/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 \ 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 923.09 4.086 0 simundump kreac /kinetics/chain/kinetics[18]/Ras/GEF*/diff 0 0.001 0.001 "" \ white black 923.45 8.246 0 simundump kpool /kinetics/chain/kinetics[18]/Ras/GTP-Ras 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange blue 928.56 1.084 0 simundump kpool /kinetics/chain/kinetics[18]/Ras/GDP-Ras 1 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink blue 922.13 2.165 0 simundump kreac /kinetics/chain/kinetics[18]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 925.1 1.5 0 simundump kreac /kinetics/chain/kinetics[18]/Ras/dephosph-GAP 1 0.1 0 "" \ white blue 920.02 3.524 0 simundump kpool /kinetics/chain/kinetics[18]/Ras/GAP* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red blue 917.35 2.349 0 simundump kreac /kinetics/chain/kinetics[18]/Ras/GAP*/diff 0 0.001 0.001 "" \ white black 918.35 5.349 0 simundump kpool /kinetics/chain/kinetics[18]/Ras/GAP 1 -1e-12 0.01 0.01 \ 753.96 753.96 0 0 75396 0 /kinetics/dendgeom red blue 922.66 0.338 0 simundump kenz /kinetics/chain/kinetics[18]/Ras/GAP/GAP-inact-ras 1 0 0 0 0 \ 75396 0.00065634 40 10 0 0 "" red red "" 925.01 0.403 0 simundump kreac /kinetics/chain/kinetics[18]/Ras/GAP/diff 0 0.001 0.001 "" \ white black 923.66 3.338 0 simundump kreac /kinetics/chain/kinetics[18]/Ras/CaM-bind-GEF 1 0.0026526 1 \ "" white blue 918.49 9.679 0 simundump kpool /kinetics/chain/kinetics[18]/Ras/CaM-GEF 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 921.34 7.58 0 simundump kenz /kinetics/chain/kinetics[18]/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 \ 0 0 75396 1.3131e-05 0.4 0.1 0 0 "" red pink "" 921.02 6.657 0 simundump kreac /kinetics/chain/kinetics[18]/Ras/CaM-GEF/diff 0 0.001 0.001 \ "" white black 922.34 10.58 0 simundump kpool /kinetics/chain/kinetics[18]/Ca 1 -1e-12 0.095 0.095 7162.6 \ 7162.6 0 0 75396 4 /kinetics/dendgeom red black 901 -13 0 simundump kpool /kinetics/chain/kinetics[18]/DAG 1 -1e-12 12.2 12.2 \ 9.1983e+05 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 916.72 \ -19.562 0 simundump kpool /kinetics/chain/kinetics[18]/PKC-active 1 -1e-12 0.3 \ 2.1196e-16 1.5981e-11 22619 0 0 75396 2 /kinetics/dendgeom red black 916 -3 \ 0 simundump kenz /kinetics/chain/kinetics[18]/PKC-active/PKC-act-raf 1 0 0 0 0 \ 75396 3.979e-06 16 4 0 0 "" red yellow "" 922 -2 0 simundump kenz /kinetics/chain/kinetics[18]/PKC-active/PKC-inact-GAP 1 0 0 0 \ 0 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 920 1 0 simundump kenz /kinetics/chain/kinetics[18]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 925 8 0 simundump kenz /kinetics/chain/kinetics[18]/PKC-active/phosph-AC2 1 0 0 0 0 \ 75396 0.00066667 16 4 0 0 "" red red "" 909.32 -23.269 0 simundump kpool /kinetics/chain/kinetics[18]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 929 -11 0 simundump kenz /kinetics/chain/kinetics[18]/MAPK*/MAPK* 0 0 0 0 0 75396 \ 2.5864e-05 40 10 0 0 "" red orange "" 904 -26 0 simundump kenz /kinetics/chain/kinetics[18]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange "" 926 -2 0 simundump kreac /kinetics/chain/kinetics[18]/MAPK*/diff 0 0.001 0.001 "" \ white black 930 -8 0 simundump kpool /kinetics/chain/kinetics[18]/IP3 1 -1e-12 0.73 0.73 55039 \ 55039 0 0 75396 4 /kinetics/dendgeom pink black 915.23 -16.656 0 simundump kpool /kinetics/chain/kinetics[18]/MKP-1 1 -1e-12 0.024 0.024 \ 1809.5 1809.5 0 0 75396 0 /kinetics/dendgeom hotpink black 921 -10 0 simundump kenz /kinetics/chain/kinetics[18]/MKP-1/MKP1-tyr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 922 -9 0 simundump kenz /kinetics/chain/kinetics[18]/MKP-1/MKP1-thr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 927 -9 0 simundump kreac /kinetics/chain/kinetics[18]/MKP-1/diff 0 0.001 0.001 "" \ white black 922 -7 0 simundump kpool /kinetics/chain/kinetics[18]/PPhosphatase2A 1 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom hotpink yellow 925 -3 0 simundump kenz /kinetics/chain/kinetics[18]/PPhosphatase2A/craf-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 924 -2 0 simundump kenz /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 927 -5 0 simundump kenz /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph-ser 1 0 \ 0 0 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 924 -5 0 simundump kenz /kinetics/chain/kinetics[18]/PPhosphatase2A/craf**-deph 1 0 0 \ 0 0 0.12566 2.5414e-05 24 6 0 0 "" red hotpink "" 928 -2 0 simundump kreac /kinetics/chain/kinetics[18]/PPhosphatase2A/diff 0 0.001 \ 0.001 "" white black 926 0 0 simundump group /kinetics/chain/kinetics[18]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 903 -9 0 simundump kpool /kinetics/chain/kinetics[18]/CaM/CaM 1 -1e-12 20 20 \ 1.5079e+06 1.5079e+06 0 0 75396 0 /kinetics/dendgeom pink blue 902.98 -1.28 \ 0 simundump kreac /kinetics/chain/kinetics[18]/CaM/CaM/diff 0 0.001 0.001 "" \ white black 903.98 1.72 0 simundump kreac /kinetics/chain/kinetics[18]/CaM/CaM-TR2-bind-Ca 1 1.2666e-08 \ 72 "" white blue 905.16 -1.921 0 simundump kreac /kinetics/chain/kinetics[18]/CaM/CaM-TR2-Ca2-bind-Ca 1 \ 4.7748e-05 10 "" white blue 904.16 -3.7747 0 simundump kreac /kinetics/chain/kinetics[18]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 902.6 -6.7404 0 simundump kpool /kinetics/chain/kinetics[18]/CaM/CaM-Ca3 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 906.49 -5.603 0 simundump kreac /kinetics/chain/kinetics[18]/CaM/CaM-Ca3/diff 0 0.001 0.001 \ "" white black 907.49 -2.603 0 simundump kpool /kinetics/chain/kinetics[18]/CaM/CaM-TR2-Ca2 1 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 908 -2.7423 0 simundump kreac /kinetics/chain/kinetics[18]/CaM/CaM-TR2-Ca2/diff 0 0.001 \ 0.001 "" white black 909 0.2577 0 simundump kpool /kinetics/chain/kinetics[18]/CaM/CaM-Ca4 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom blue blue 908 -8 0 simundump kreac /kinetics/chain/kinetics[18]/CaM/CaM-Ca4/diff 0 0.001 0.001 \ "" white black 909 -5 0 simundump kreac /kinetics/chain/kinetics[18]/Ras-act-unphosph-raf 0 7.958e-05 \ 1 "" white black 920 -4 0 simundump kpool /kinetics/chain/kinetics[18]/Ca_input 0 -1e-12 0.08 0.08 \ 6031.7 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 894 -7 0 simundump kreac /kinetics/chain/kinetics[18]/Ca_diff 0 2 2 "" white black 895 \ -12 0 simundump group /kinetics/chain/kinetics[19] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 954 0 0 simundump group /kinetics/chain/kinetics[19]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 962.95 -3.7837 0 simundump kpool /kinetics/chain/kinetics[19]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 961.92 -10.489 0 simundump kreac /kinetics/chain/kinetics[19]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 962.92 -7.489 0 simundump kreac /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 961.92 -12.123 0 simundump kreac /kinetics/chain/kinetics[19]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 963.94 -11.306 0 simundump kreac /kinetics/chain/kinetics[19]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 962.2 -7.7467 0 simundump kreac /kinetics/chain/kinetics[19]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 963.38 -9.2638 0 simundump kreac /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca-AA 0 \ 1.5916e-08 0.1 "" white blue 965.21 -8.1843 0 simundump kreac /kinetics/chain/kinetics[19]/PKC/PKC-act-by-DAG-AA 0 2 0.2 "" \ white blue 967.25 -8.7678 0 simundump kpool /kinetics/chain/kinetics[19]/PKC/PKC-DAG-AA* 0 -1e-12 \ 4.9137e-18 4.9137e-18 3.7047e-13 3.7047e-13 0 0 75396 0 /kinetics/dendgeom \ cyan blue 966.6 -6.463 0 simundump kreac /kinetics/chain/kinetics[19]/PKC/PKC-DAG-AA*/diff 0 0.001 \ 0.001 "" white black 967.6 -3.463 0 simundump kpool /kinetics/chain/kinetics[19]/PKC/PKC-Ca-AA* 0 -1e-12 \ 1.7501e-16 1.7501e-16 1.3195e-11 1.3195e-11 0 0 75396 0 /kinetics/dendgeom \ orange blue 965.4 -5.7044 0 simundump kreac /kinetics/chain/kinetics[19]/PKC/PKC-Ca-AA*/diff 0 0.001 \ 0.001 "" white black 966.4 -2.7044 0 simundump kpool /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb* 0 -1e-12 \ 1.3896e-17 1.3896e-17 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom \ pink blue 963.22 -5.471 0 simundump kreac /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb*/diff 0 0.001 \ 0.001 "" white black 964.22 -2.471 0 simundump kpool /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb* 0 -1e-12 \ 9.4351e-21 9.4351e-21 7.1137e-16 7.1137e-16 0 0 75396 0 /kinetics/dendgeom \ yellow blue 964.17 -6.4922 0 simundump kreac /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb*/diff 0 0.001 \ 0.001 "" white black 965.17 -3.4922 0 simundump kpool /kinetics/chain/kinetics[19]/PKC/PKC-basal* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 961.25 -6.4338 0 simundump kreac /kinetics/chain/kinetics[19]/PKC/PKC-basal*/diff 0 0.001 \ 0.001 "" white black 962.25 -3.4338 0 simundump kreac /kinetics/chain/kinetics[19]/PKC/PKC-basal-act 0 1 50 "" \ white blue 961.02 -8.9429 0 simundump kpool /kinetics/chain/kinetics[19]/PKC/PKC-AA* 0 -1e-12 1.8134e-17 \ 1.8134e-17 1.3672e-12 1.3672e-12 0 0 75396 0 /kinetics/dendgeom cyan blue \ 967.78 -5.1793 0 simundump kreac /kinetics/chain/kinetics[19]/PKC/PKC-AA*/diff 0 0.001 0.001 \ "" white black 968.78 -2.1793 0 simundump kreac /kinetics/chain/kinetics[19]/PKC/PKC-act-by-AA 0 1.5916e-09 \ 0.1 "" white blue 961.01 -13.865 0 simundump kpool /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG 0 -1e-12 \ 8.4632e-23 8.4632e-23 6.3809e-18 6.3809e-18 0 0 75396 0 /kinetics/dendgeom \ white blue 966.23 -10.197 0 simundump kreac /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG/diff 0 0.001 \ 0.001 "" white black 967.23 -7.197 0 simundump kreac /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 962.99 -13.99 0 simundump kpool /kinetics/chain/kinetics[19]/PKC/PKC-DAG 0 -1e-12 1.161e-16 \ 1.161e-16 8.7535e-12 8.7535e-12 0 0 75396 0 /kinetics/dendgeom white blue \ 965 -13.086 0 simundump kreac /kinetics/chain/kinetics[19]/PKC/PKC-DAG/diff 0 0.001 0.001 \ "" white black 966 -10.086 0 simundump kreac /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG-AA 0 2.3874e-07 2 \ "" white blue 964.77 -14.953 0 simundump kpool /kinetics/chain/kinetics[19]/PKC/PKC-DAG-AA 0 -1e-12 \ 2.5188e-19 2.5188e-19 1.8991e-14 1.8991e-14 0 0 75396 0 /kinetics/dendgeom \ white blue 966.62 -11.773 0 simundump kreac /kinetics/chain/kinetics[19]/PKC/PKC-DAG-AA/diff 0 0.001 \ 0.001 "" white black 967.62 -8.773 0 simundump kpool /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic 0 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom white blue 959.87 -11.403 0 simundump kreac /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic/diff 0 0.001 \ 0.001 "" white black 960.87 -8.403 0 simundump kpool /kinetics/chain/kinetics[19]/AA 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom darkgreen black 962.71 -21.338 0 simundump kreac /kinetics/chain/kinetics[19]/AA/diff 0 0.001 0.001 "" white \ black 963.71 -18.338 0 simundump group /kinetics/chain/kinetics[19]/PLA2 0 darkgreen black x 0 1 "" \ defaultfile defaultfile.g 0 0 0 958.64 -26.209 0 simundump kpool /kinetics/chain/kinetics[19]/PLA2/PLA2-cytosolic 0 -1e-12 \ 0.39999 0.39999 30158 30158 0 0 75396 0 /kinetics/dendgeom yellow darkgreen \ 954.18 -20.942 0 simundump kreac /kinetics/chain/kinetics[19]/PLA2/PLA2-cytosolic/diff 0 0.001 \ 0.001 "" white black 955.18 -17.942 0 simundump kreac /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca-act 0 1.3263e-05 \ 0.1 "" white darkgreen 954.9 -23.104 0 simundump kpool /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom yellow darkgreen 957.28 -23.646 0 simundump kenz /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca*/kenz 0 0 0 0 0 \ 75396 1.7906e-05 21.6 5.4 0 0 "" red yellow "" 959.94 -23.667 0 simundump kreac /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca*/diff 0 0.001 0.001 \ "" white black 958.28 -20.646 0 simundump kreac /kinetics/chain/kinetics[19]/PLA2/PIP2-PLA2-act 0 1.5916e-08 \ 0.5 "" white darkgreen 954.95 -18.75 0 simundump kpool /kinetics/chain/kinetics[19]/PLA2/PIP2-PLA2* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 957.32 -18.292 0 simundump kenz /kinetics/chain/kinetics[19]/PLA2/PIP2-PLA2*/kenz 0 0 0 0 0 \ 75396 3.6607e-05 44.16 11.04 0 0 "" red cyan "" 959.97 -18.271 0 simundump kreac /kinetics/chain/kinetics[19]/PLA2/PIP2-PLA2*/diff 0 0.001 \ 0.001 "" white black 958.32 -15.292 0 simundump kreac /kinetics/chain/kinetics[19]/PLA2/PIP2-Ca-PLA2-act 0 \ 1.5916e-07 0.1 "" white darkgreen 955.9 -19.5 0 simundump kpool /kinetics/chain/kinetics[19]/PLA2/PIP2-Ca-PLA2* 0 -1e-12 0 0 \ 0 0 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 957.67 -19.896 0 simundump kenz /kinetics/chain/kinetics[19]/PLA2/PIP2-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00011937 144 36 0 0 "" red cyan "" 960.03 -19.979 0 simundump kreac /kinetics/chain/kinetics[19]/PLA2/PIP2-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 958.67 -16.896 0 simundump kreac /kinetics/chain/kinetics[19]/PLA2/DAG-Ca-PLA2-act 0 3.979e-08 \ 4 "" white darkgreen 955.17 -21.834 0 simundump kpool /kinetics/chain/kinetics[19]/PLA2/DAG-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom pink darkgreen 957.86 -22.479 0 simundump kenz /kinetics/chain/kinetics[19]/PLA2/DAG-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00019895 240 60 0 0 "" red pink "" 960.05 -22.354 0 simundump kreac /kinetics/chain/kinetics[19]/PLA2/DAG-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 958.86 -19.479 0 simundump kpool /kinetics/chain/kinetics[19]/PLA2/APC 0 -1e-12 30 30 \ 2.2619e+06 2.2619e+06 0 0 75396 4 /kinetics/dendgeom yellow darkgreen \ 957.76 -21.963 0 simundump kreac /kinetics/chain/kinetics[19]/PLA2/Degrade-AA 1 0.4 0 "" white \ darkgreen 959.82 -17.288 0 simundump kpool /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange darkgreen 958.19 -24.687 0 simundump kenz /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca/kenz 0 0 0 0 0 \ 75396 0.0003979 480 120 0 0 "" red orange "" 959.92 -24.817 0 simundump kreac /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca/diff 0 0.001 0.001 \ "" white black 959.19 -21.687 0 simundump kpool /kinetics/chain/kinetics[19]/PLA2/PLA2* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange darkgreen 956.97 -26.851 0 simundump kreac /kinetics/chain/kinetics[19]/PLA2/PLA2*/diff 0 0.001 0.001 "" \ white black 957.97 -23.851 0 simundump kreac /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca-act 1 7.958e-05 \ 0.1 "" white darkgreen 955.91 -24.752 0 simundump kreac /kinetics/chain/kinetics[19]/PLA2/dephosphorylate-PLA2* 1 \ 0.17 0 "" white darkgreen 952.31 -23.735 0 simundump kpool /kinetics/chain/kinetics[19]/temp-PIP2 1 -1e-12 2.5 2.5 \ 1.8849e+05 1.8849e+05 0 0 75396 4 /kinetics/dendgeom green black 950.2 \ -19.047 0 simundump group /kinetics/chain/kinetics[19]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 981 -1 0 simundump kpool /kinetics/chain/kinetics[19]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 972 -4 0 simundump kpool /kinetics/chain/kinetics[19]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 975 -4 0 simundump kpool /kinetics/chain/kinetics[19]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 972 -8 0 simundump kpool /kinetics/chain/kinetics[19]/MAPK/MAPK 0 -1e-12 3.5999 3.5999 \ 2.7142e+05 2.7142e+05 0 0 75396 0 /kinetics/dendgeom pink brown 972 -11 0 simundump kreac /kinetics/chain/kinetics[19]/MAPK/MAPK/diff 0 0.001 0.001 "" \ white black 973 -8 0 simundump kpool /kinetics/chain/kinetics[19]/MAPK/craf-1** 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink brown 978 -4 0 simundump kpool /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr 1 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange brown 975 -11 0 simundump kreac /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr/diff 0 0.001 0.001 \ "" white black 976 -8 0 simundump kpool /kinetics/chain/kinetics[19]/MAPK/MAPKK* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 979 -8 0 simundump kenz /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 974 -9 0 simundump kenz /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 979 -9 0 simundump kpool /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 975 -8 0 simundump kpool /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 971 -6 0 simundump kenz /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 974 -6 0 simundump kenz /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 977 -6 0 simundump kpool /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom red brown 971 -7 0 simundump kenz /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 974 -7 0 simundump kenz /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 977 -7 0 simundump kreac /kinetics/chain/kinetics[19]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 969 -3 0 simundump group /kinetics/chain/kinetics[19]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 980.51 4.351 0 simundump kreac /kinetics/chain/kinetics[19]/Ras/dephosph-GEF 1 1 0 "" white \ blue 975.07 5.881 0 simundump kpool /kinetics/chain/kinetics[19]/Ras/inact-GEF 1 -1e-12 0.1 0.1 \ 7539.6 7539.6 0 0 75396 0 /kinetics/dendgeom hotpink blue 978.45 6.352 0 simundump kenz /kinetics/chain/kinetics[19]/Ras/inact-GEF/basal_GEF_activity 0 \ 0 0 0 0 75396 1.313e-07 0.08 0.02 0 0 "" red hotpink "" 977 5 0 simundump kreac /kinetics/chain/kinetics[19]/Ras/inact-GEF/diff 0 0.001 0.001 \ "" white black 979.45 9.352 0 simundump kpool /kinetics/chain/kinetics[19]/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 972.45 5.246 0 simundump kenz /kinetics/chain/kinetics[19]/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 \ 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 973.09 4.086 0 simundump kreac /kinetics/chain/kinetics[19]/Ras/GEF*/diff 0 0.001 0.001 "" \ white black 973.45 8.246 0 simundump kpool /kinetics/chain/kinetics[19]/Ras/GTP-Ras 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange blue 978.56 1.084 0 simundump kpool /kinetics/chain/kinetics[19]/Ras/GDP-Ras 1 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink blue 972.13 2.165 0 simundump kreac /kinetics/chain/kinetics[19]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 975.1 1.5 0 simundump kreac /kinetics/chain/kinetics[19]/Ras/dephosph-GAP 1 0.1 0 "" \ white blue 970.02 3.524 0 simundump kpool /kinetics/chain/kinetics[19]/Ras/GAP* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red blue 967.35 2.349 0 simundump kreac /kinetics/chain/kinetics[19]/Ras/GAP*/diff 0 0.001 0.001 "" \ white black 968.35 5.349 0 simundump kpool /kinetics/chain/kinetics[19]/Ras/GAP 1 -1e-12 0.01 0.01 \ 753.96 753.96 0 0 75396 0 /kinetics/dendgeom red blue 972.66 0.338 0 simundump kenz /kinetics/chain/kinetics[19]/Ras/GAP/GAP-inact-ras 1 0 0 0 0 \ 75396 0.00065634 40 10 0 0 "" red red "" 975.01 0.403 0 simundump kreac /kinetics/chain/kinetics[19]/Ras/GAP/diff 0 0.001 0.001 "" \ white black 973.66 3.338 0 simundump kreac /kinetics/chain/kinetics[19]/Ras/CaM-bind-GEF 1 0.0026526 1 \ "" white blue 968.49 9.679 0 simundump kpool /kinetics/chain/kinetics[19]/Ras/CaM-GEF 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 971.34 7.58 0 simundump kenz /kinetics/chain/kinetics[19]/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 \ 0 0 75396 1.3131e-05 0.4 0.1 0 0 "" red pink "" 971.02 6.657 0 simundump kreac /kinetics/chain/kinetics[19]/Ras/CaM-GEF/diff 0 0.001 0.001 \ "" white black 972.34 10.58 0 simundump kpool /kinetics/chain/kinetics[19]/Ca 1 -1e-12 0.095 0.095 7162.6 \ 7162.6 0 0 75396 4 /kinetics/dendgeom red black 951 -13 0 simundump kpool /kinetics/chain/kinetics[19]/DAG 1 -1e-12 12.2 12.2 \ 9.1983e+05 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 966.72 \ -19.562 0 simundump kpool /kinetics/chain/kinetics[19]/PKC-active 1 -1e-12 0.3 \ 2.1196e-16 1.5981e-11 22619 0 0 75396 2 /kinetics/dendgeom red black 966 -3 \ 0 simundump kenz /kinetics/chain/kinetics[19]/PKC-active/PKC-act-raf 1 0 0 0 0 \ 75396 3.979e-06 16 4 0 0 "" red yellow "" 972 -2 0 simundump kenz /kinetics/chain/kinetics[19]/PKC-active/PKC-inact-GAP 1 0 0 0 \ 0 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 970 1 0 simundump kenz /kinetics/chain/kinetics[19]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 975 8 0 simundump kenz /kinetics/chain/kinetics[19]/PKC-active/phosph-AC2 1 0 0 0 0 \ 75396 0.00066667 16 4 0 0 "" red red "" 959.32 -23.269 0 simundump kpool /kinetics/chain/kinetics[19]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 979 -11 0 simundump kenz /kinetics/chain/kinetics[19]/MAPK*/MAPK* 0 0 0 0 0 75396 \ 2.5864e-05 40 10 0 0 "" red orange "" 954 -26 0 simundump kenz /kinetics/chain/kinetics[19]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange "" 976 -2 0 simundump kreac /kinetics/chain/kinetics[19]/MAPK*/diff 0 0.001 0.001 "" \ white black 980 -8 0 simundump kpool /kinetics/chain/kinetics[19]/IP3 1 -1e-12 0.73 0.73 55039 \ 55039 0 0 75396 4 /kinetics/dendgeom pink black 965.23 -16.656 0 simundump kpool /kinetics/chain/kinetics[19]/MKP-1 1 -1e-12 0.024 0.024 \ 1809.5 1809.5 0 0 75396 0 /kinetics/dendgeom hotpink black 971 -10 0 simundump kenz /kinetics/chain/kinetics[19]/MKP-1/MKP1-tyr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 972 -9 0 simundump kenz /kinetics/chain/kinetics[19]/MKP-1/MKP1-thr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 977 -9 0 simundump kreac /kinetics/chain/kinetics[19]/MKP-1/diff 0 0.001 0.001 "" \ white black 972 -7 0 simundump kpool /kinetics/chain/kinetics[19]/PPhosphatase2A 1 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom hotpink yellow 975 -3 0 simundump kenz /kinetics/chain/kinetics[19]/PPhosphatase2A/craf-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 974 -2 0 simundump kenz /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 977 -5 0 simundump kenz /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph-ser 1 0 \ 0 0 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 974 -5 0 simundump kenz /kinetics/chain/kinetics[19]/PPhosphatase2A/craf**-deph 1 0 0 \ 0 0 0.12566 2.5414e-05 24 6 0 0 "" red hotpink "" 978 -2 0 simundump kreac /kinetics/chain/kinetics[19]/PPhosphatase2A/diff 0 0.001 \ 0.001 "" white black 976 0 0 simundump group /kinetics/chain/kinetics[19]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 953 -9 0 simundump kpool /kinetics/chain/kinetics[19]/CaM/CaM 1 -1e-12 20 20 \ 1.5079e+06 1.5079e+06 0 0 75396 0 /kinetics/dendgeom pink blue 952.98 -1.28 \ 0 simundump kreac /kinetics/chain/kinetics[19]/CaM/CaM/diff 0 0.001 0.001 "" \ white black 953.98 1.72 0 simundump kreac /kinetics/chain/kinetics[19]/CaM/CaM-TR2-bind-Ca 1 1.2666e-08 \ 72 "" white blue 955.16 -1.921 0 simundump kreac /kinetics/chain/kinetics[19]/CaM/CaM-TR2-Ca2-bind-Ca 1 \ 4.7748e-05 10 "" white blue 954.16 -3.7747 0 simundump kreac /kinetics/chain/kinetics[19]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 952.6 -6.7404 0 simundump kpool /kinetics/chain/kinetics[19]/CaM/CaM-Ca3 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 956.49 -5.603 0 simundump kreac /kinetics/chain/kinetics[19]/CaM/CaM-Ca3/diff 0 0.001 0.001 \ "" white black 957.49 -2.603 0 simundump kpool /kinetics/chain/kinetics[19]/CaM/CaM-TR2-Ca2 1 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 958 -2.7423 0 simundump kreac /kinetics/chain/kinetics[19]/CaM/CaM-TR2-Ca2/diff 0 0.001 \ 0.001 "" white black 959 0.2577 0 simundump kpool /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom blue blue 958 -8 0 simundump kreac /kinetics/chain/kinetics[19]/CaM/CaM-Ca4/diff 0 0.001 0.001 \ "" white black 959 -5 0 simundump kreac /kinetics/chain/kinetics[19]/Ras-act-unphosph-raf 0 7.958e-05 \ 1 "" white black 970 -4 0 simundump kpool /kinetics/chain/kinetics[19]/Ca_input 0 -1e-12 0.08 0.08 \ 6031.7 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 944 -7 0 simundump kreac /kinetics/chain/kinetics[19]/Ca_diff 0 2 2 "" white black 945 \ -12 0 simundump group /kinetics/chain/kinetics[20] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 1004 0 0 simundump group /kinetics/chain/kinetics[20]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 1013 -3.7837 0 simundump kpool /kinetics/chain/kinetics[20]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 1011.9 -10.489 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 1012.9 -7.489 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 1011.9 -12.123 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 1013.9 -11.306 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 1012.2 -7.7467 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 1013.4 -9.2638 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca-AA 0 \ 1.5916e-08 0.1 "" white blue 1015.2 -8.1843 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG-AA 0 2 0.2 "" \ white blue 1017.2 -8.7678 0 simundump kpool /kinetics/chain/kinetics[20]/PKC/PKC-DAG-AA* 0 -1e-12 \ 4.9137e-18 4.9137e-18 3.7047e-13 3.7047e-13 0 0 75396 0 /kinetics/dendgeom \ cyan blue 1016.6 -6.463 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-DAG-AA*/diff 0 0.001 \ 0.001 "" white black 1017.6 -3.463 0 simundump kpool /kinetics/chain/kinetics[20]/PKC/PKC-Ca-AA* 0 -1e-12 \ 1.7501e-16 1.7501e-16 1.3195e-11 1.3195e-11 0 0 75396 0 /kinetics/dendgeom \ orange blue 1015.4 -5.7044 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-Ca-AA*/diff 0 0.001 \ 0.001 "" white black 1016.4 -2.7044 0 simundump kpool /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb* 0 -1e-12 \ 1.3896e-17 1.3896e-17 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom \ pink blue 1013.2 -5.471 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb*/diff 0 0.001 \ 0.001 "" white black 1014.2 -2.471 0 simundump kpool /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb* 0 -1e-12 \ 9.4351e-21 9.4351e-21 7.1137e-16 7.1137e-16 0 0 75396 0 /kinetics/dendgeom \ yellow blue 1014.2 -6.4922 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb*/diff 0 0.001 \ 0.001 "" white black 1015.2 -3.4922 0 simundump kpool /kinetics/chain/kinetics[20]/PKC/PKC-basal* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 1011.3 -6.4338 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-basal*/diff 0 0.001 \ 0.001 "" white black 1012.3 -3.4338 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-basal-act 0 1 50 "" \ white blue 1011 -8.9429 0 simundump kpool /kinetics/chain/kinetics[20]/PKC/PKC-AA* 0 -1e-12 1.8134e-17 \ 1.8134e-17 1.3672e-12 1.3672e-12 0 0 75396 0 /kinetics/dendgeom cyan blue \ 1017.8 -5.1793 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-AA*/diff 0 0.001 0.001 \ "" white black 1018.8 -2.1793 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-act-by-AA 0 1.5916e-09 \ 0.1 "" white blue 1011 -13.865 0 simundump kpool /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG 0 -1e-12 \ 8.4632e-23 8.4632e-23 6.3809e-18 6.3809e-18 0 0 75396 0 /kinetics/dendgeom \ white blue 1016.2 -10.197 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG/diff 0 0.001 \ 0.001 "" white black 1017.2 -7.197 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 1013 -13.99 0 simundump kpool /kinetics/chain/kinetics[20]/PKC/PKC-DAG 0 -1e-12 1.161e-16 \ 1.161e-16 8.7535e-12 8.7535e-12 0 0 75396 0 /kinetics/dendgeom white blue \ 1015 -13.086 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-DAG/diff 0 0.001 0.001 \ "" white black 1016 -10.086 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG-AA 0 2.3874e-07 2 \ "" white blue 1014.8 -14.953 0 simundump kpool /kinetics/chain/kinetics[20]/PKC/PKC-DAG-AA 0 -1e-12 \ 2.5188e-19 2.5188e-19 1.8991e-14 1.8991e-14 0 0 75396 0 /kinetics/dendgeom \ white blue 1016.6 -11.773 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-DAG-AA/diff 0 0.001 \ 0.001 "" white black 1017.6 -8.773 0 simundump kpool /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic 0 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom white blue 1009.9 -11.403 0 simundump kreac /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic/diff 0 0.001 \ 0.001 "" white black 1010.9 -8.403 0 simundump kpool /kinetics/chain/kinetics[20]/AA 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom darkgreen black 1012.7 -21.338 0 simundump kreac /kinetics/chain/kinetics[20]/AA/diff 0 0.001 0.001 "" white \ black 1013.7 -18.338 0 simundump group /kinetics/chain/kinetics[20]/PLA2 0 darkgreen black x 0 1 "" \ defaultfile defaultfile.g 0 0 0 1008.6 -26.209 0 simundump kpool /kinetics/chain/kinetics[20]/PLA2/PLA2-cytosolic 0 -1e-12 \ 0.39999 0.39999 30158 30158 0 0 75396 0 /kinetics/dendgeom yellow darkgreen \ 1004.2 -20.942 0 simundump kreac /kinetics/chain/kinetics[20]/PLA2/PLA2-cytosolic/diff 0 0.001 \ 0.001 "" white black 1005.2 -17.942 0 simundump kreac /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca-act 0 1.3263e-05 \ 0.1 "" white darkgreen 1004.9 -23.104 0 simundump kpool /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom yellow darkgreen 1007.3 -23.646 0 simundump kenz /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca*/kenz 0 0 0 0 0 \ 75396 1.7906e-05 21.6 5.4 0 0 "" red yellow "" 1009.9 -23.667 0 simundump kreac /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca*/diff 0 0.001 0.001 \ "" white black 1008.3 -20.646 0 simundump kreac /kinetics/chain/kinetics[20]/PLA2/PIP2-PLA2-act 0 1.5916e-08 \ 0.5 "" white darkgreen 1004.9 -18.75 0 simundump kpool /kinetics/chain/kinetics[20]/PLA2/PIP2-PLA2* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 1007.3 -18.292 0 simundump kenz /kinetics/chain/kinetics[20]/PLA2/PIP2-PLA2*/kenz 0 0 0 0 0 \ 75396 3.6607e-05 44.16 11.04 0 0 "" red cyan "" 1010 -18.271 0 simundump kreac /kinetics/chain/kinetics[20]/PLA2/PIP2-PLA2*/diff 0 0.001 \ 0.001 "" white black 1008.3 -15.292 0 simundump kreac /kinetics/chain/kinetics[20]/PLA2/PIP2-Ca-PLA2-act 0 \ 1.5916e-07 0.1 "" white darkgreen 1005.9 -19.5 0 simundump kpool /kinetics/chain/kinetics[20]/PLA2/PIP2-Ca-PLA2* 0 -1e-12 0 0 \ 0 0 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 1007.7 -19.896 0 simundump kenz /kinetics/chain/kinetics[20]/PLA2/PIP2-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00011937 144 36 0 0 "" red cyan "" 1010 -19.979 0 simundump kreac /kinetics/chain/kinetics[20]/PLA2/PIP2-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 1008.7 -16.896 0 simundump kreac /kinetics/chain/kinetics[20]/PLA2/DAG-Ca-PLA2-act 0 3.979e-08 \ 4 "" white darkgreen 1005.2 -21.834 0 simundump kpool /kinetics/chain/kinetics[20]/PLA2/DAG-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom pink darkgreen 1007.9 -22.479 0 simundump kenz /kinetics/chain/kinetics[20]/PLA2/DAG-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00019895 240 60 0 0 "" red pink "" 1010 -22.354 0 simundump kreac /kinetics/chain/kinetics[20]/PLA2/DAG-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 1008.9 -19.479 0 simundump kpool /kinetics/chain/kinetics[20]/PLA2/APC 0 -1e-12 30 30 \ 2.2619e+06 2.2619e+06 0 0 75396 4 /kinetics/dendgeom yellow darkgreen \ 1007.8 -21.963 0 simundump kreac /kinetics/chain/kinetics[20]/PLA2/Degrade-AA 1 0.4 0 "" white \ darkgreen 1009.8 -17.288 0 simundump kpool /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange darkgreen 1008.2 -24.687 0 simundump kenz /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca/kenz 0 0 0 0 0 \ 75396 0.0003979 480 120 0 0 "" red orange "" 1009.9 -24.817 0 simundump kreac /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca/diff 0 0.001 0.001 \ "" white black 1009.2 -21.687 0 simundump kpool /kinetics/chain/kinetics[20]/PLA2/PLA2* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange darkgreen 1007 -26.851 0 simundump kreac /kinetics/chain/kinetics[20]/PLA2/PLA2*/diff 0 0.001 0.001 "" \ white black 1008 -23.851 0 simundump kreac /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca-act 1 7.958e-05 \ 0.1 "" white darkgreen 1005.9 -24.752 0 simundump kreac /kinetics/chain/kinetics[20]/PLA2/dephosphorylate-PLA2* 1 \ 0.17 0 "" white darkgreen 1002.3 -23.735 0 simundump kpool /kinetics/chain/kinetics[20]/temp-PIP2 1 -1e-12 2.5 2.5 \ 1.8849e+05 1.8849e+05 0 0 75396 4 /kinetics/dendgeom green black 1000.2 \ -19.047 0 simundump group /kinetics/chain/kinetics[20]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 1031 -1 0 simundump kpool /kinetics/chain/kinetics[20]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 1022 -4 0 simundump kpool /kinetics/chain/kinetics[20]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 1025 -4 0 simundump kpool /kinetics/chain/kinetics[20]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 1022 -8 0 simundump kpool /kinetics/chain/kinetics[20]/MAPK/MAPK 0 -1e-12 3.5999 3.5999 \ 2.7142e+05 2.7142e+05 0 0 75396 0 /kinetics/dendgeom pink brown 1022 -11 0 simundump kreac /kinetics/chain/kinetics[20]/MAPK/MAPK/diff 0 0.001 0.001 "" \ white black 1023 -8 0 simundump kpool /kinetics/chain/kinetics[20]/MAPK/craf-1** 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink brown 1028 -4 0 simundump kpool /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr 1 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange brown 1025 -11 0 simundump kreac /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr/diff 0 0.001 0.001 \ "" white black 1026 -8 0 simundump kpool /kinetics/chain/kinetics[20]/MAPK/MAPKK* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 1029 -8 0 simundump kenz /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 1024 -9 0 simundump kenz /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 1029 -9 0 simundump kpool /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 1025 -8 0 simundump kpool /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 1021 -6 0 simundump kenz /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 1024 -6 0 simundump kenz /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 1027 -6 0 simundump kpool /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom red brown 1021 -7 0 simundump kenz /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 1024 -7 0 simundump kenz /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 1027 -7 0 simundump kreac /kinetics/chain/kinetics[20]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 1019 -3 0 simundump group /kinetics/chain/kinetics[20]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 1030.5 4.351 0 simundump kreac /kinetics/chain/kinetics[20]/Ras/dephosph-GEF 1 1 0 "" white \ blue 1025.1 5.881 0 simundump kpool /kinetics/chain/kinetics[20]/Ras/inact-GEF 1 -1e-12 0.1 0.1 \ 7539.6 7539.6 0 0 75396 0 /kinetics/dendgeom hotpink blue 1028.5 6.352 0 simundump kenz /kinetics/chain/kinetics[20]/Ras/inact-GEF/basal_GEF_activity 0 \ 0 0 0 0 75396 1.313e-07 0.08 0.02 0 0 "" red hotpink "" 1027 5 0 simundump kreac /kinetics/chain/kinetics[20]/Ras/inact-GEF/diff 0 0.001 0.001 \ "" white black 1029.5 9.352 0 simundump kpool /kinetics/chain/kinetics[20]/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 1022.4 5.246 0 simundump kenz /kinetics/chain/kinetics[20]/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 \ 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 1023.1 4.086 0 simundump kreac /kinetics/chain/kinetics[20]/Ras/GEF*/diff 0 0.001 0.001 "" \ white black 1023.4 8.246 0 simundump kpool /kinetics/chain/kinetics[20]/Ras/GTP-Ras 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange blue 1028.6 1.084 0 simundump kpool /kinetics/chain/kinetics[20]/Ras/GDP-Ras 1 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink blue 1022.1 2.165 0 simundump kreac /kinetics/chain/kinetics[20]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 1025.1 1.5 0 simundump kreac /kinetics/chain/kinetics[20]/Ras/dephosph-GAP 1 0.1 0 "" \ white blue 1020 3.524 0 simundump kpool /kinetics/chain/kinetics[20]/Ras/GAP* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red blue 1017.3 2.349 0 simundump kreac /kinetics/chain/kinetics[20]/Ras/GAP*/diff 0 0.001 0.001 "" \ white black 1018.3 5.349 0 simundump kpool /kinetics/chain/kinetics[20]/Ras/GAP 1 -1e-12 0.01 0.01 \ 753.96 753.96 0 0 75396 0 /kinetics/dendgeom red blue 1022.7 0.338 0 simundump kenz /kinetics/chain/kinetics[20]/Ras/GAP/GAP-inact-ras 1 0 0 0 0 \ 75396 0.00065634 40 10 0 0 "" red red "" 1025 0.403 0 simundump kreac /kinetics/chain/kinetics[20]/Ras/GAP/diff 0 0.001 0.001 "" \ white black 1023.7 3.338 0 simundump kreac /kinetics/chain/kinetics[20]/Ras/CaM-bind-GEF 1 0.0026526 1 \ "" white blue 1018.5 9.679 0 simundump kpool /kinetics/chain/kinetics[20]/Ras/CaM-GEF 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 1021.3 7.58 0 simundump kenz /kinetics/chain/kinetics[20]/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 \ 0 0 75396 1.3131e-05 0.4 0.1 0 0 "" red pink "" 1021 6.657 0 simundump kreac /kinetics/chain/kinetics[20]/Ras/CaM-GEF/diff 0 0.001 0.001 \ "" white black 1022.3 10.58 0 simundump kpool /kinetics/chain/kinetics[20]/Ca 1 -1e-12 0.095 0.095 7162.6 \ 7162.6 0 0 75396 4 /kinetics/dendgeom red black 1001 -13 0 simundump kpool /kinetics/chain/kinetics[20]/DAG 1 -1e-12 12.2 12.2 \ 9.1983e+05 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 1016.7 \ -19.562 0 simundump kpool /kinetics/chain/kinetics[20]/PKC-active 1 -1e-12 0.3 \ 2.1196e-16 1.5981e-11 22619 0 0 75396 2 /kinetics/dendgeom red black 1016 \ -3 0 simundump kenz /kinetics/chain/kinetics[20]/PKC-active/PKC-act-raf 1 0 0 0 0 \ 75396 3.979e-06 16 4 0 0 "" red yellow "" 1022 -2 0 simundump kenz /kinetics/chain/kinetics[20]/PKC-active/PKC-inact-GAP 1 0 0 0 \ 0 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 1020 1 0 simundump kenz /kinetics/chain/kinetics[20]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 1025 8 0 simundump kenz /kinetics/chain/kinetics[20]/PKC-active/phosph-AC2 1 0 0 0 0 \ 75396 0.00066667 16 4 0 0 "" red red "" 1009.3 -23.269 0 simundump kpool /kinetics/chain/kinetics[20]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 1029 -11 0 simundump kenz /kinetics/chain/kinetics[20]/MAPK*/MAPK* 0 0 0 0 0 75396 \ 2.5864e-05 40 10 0 0 "" red orange "" 1004 -26 0 simundump kenz /kinetics/chain/kinetics[20]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange "" 1026 -2 0 simundump kreac /kinetics/chain/kinetics[20]/MAPK*/diff 0 0.001 0.001 "" \ white black 1030 -8 0 simundump kpool /kinetics/chain/kinetics[20]/IP3 1 -1e-12 0.73 0.73 55039 \ 55039 0 0 75396 4 /kinetics/dendgeom pink black 1015.2 -16.656 0 simundump kpool /kinetics/chain/kinetics[20]/MKP-1 1 -1e-12 0.024 0.024 \ 1809.5 1809.5 0 0 75396 0 /kinetics/dendgeom hotpink black 1021 -10 0 simundump kenz /kinetics/chain/kinetics[20]/MKP-1/MKP1-tyr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 1022 -9 0 simundump kenz /kinetics/chain/kinetics[20]/MKP-1/MKP1-thr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 1027 -9 0 simundump kreac /kinetics/chain/kinetics[20]/MKP-1/diff 0 0.001 0.001 "" \ white black 1022 -7 0 simundump kpool /kinetics/chain/kinetics[20]/PPhosphatase2A 1 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom hotpink yellow 1025 -3 0 simundump kenz /kinetics/chain/kinetics[20]/PPhosphatase2A/craf-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 1024 -2 0 simundump kenz /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 1027 -5 0 simundump kenz /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph-ser 1 0 \ 0 0 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 1024 -5 0 simundump kenz /kinetics/chain/kinetics[20]/PPhosphatase2A/craf**-deph 1 0 0 \ 0 0 0.12566 2.5414e-05 24 6 0 0 "" red hotpink "" 1028 -2 0 simundump kreac /kinetics/chain/kinetics[20]/PPhosphatase2A/diff 0 0.001 \ 0.001 "" white black 1026 0 0 simundump group /kinetics/chain/kinetics[20]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 1003 -9 0 simundump kpool /kinetics/chain/kinetics[20]/CaM/CaM 1 -1e-12 20 20 \ 1.5079e+06 1.5079e+06 0 0 75396 0 /kinetics/dendgeom pink blue 1003 -1.28 0 simundump kreac /kinetics/chain/kinetics[20]/CaM/CaM/diff 0 0.001 0.001 "" \ white black 1004 1.72 0 simundump kreac /kinetics/chain/kinetics[20]/CaM/CaM-TR2-bind-Ca 1 1.2666e-08 \ 72 "" white blue 1005.2 -1.921 0 simundump kreac /kinetics/chain/kinetics[20]/CaM/CaM-TR2-Ca2-bind-Ca 1 \ 4.7748e-05 10 "" white blue 1004.2 -3.7747 0 simundump kreac /kinetics/chain/kinetics[20]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 1002.6 -6.7404 0 simundump kpool /kinetics/chain/kinetics[20]/CaM/CaM-Ca3 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 1006.5 -5.603 0 simundump kreac /kinetics/chain/kinetics[20]/CaM/CaM-Ca3/diff 0 0.001 0.001 \ "" white black 1007.5 -2.603 0 simundump kpool /kinetics/chain/kinetics[20]/CaM/CaM-TR2-Ca2 1 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 1008 -2.7423 0 simundump kreac /kinetics/chain/kinetics[20]/CaM/CaM-TR2-Ca2/diff 0 0.001 \ 0.001 "" white black 1009 0.2577 0 simundump kpool /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom blue blue 1008 -8 0 simundump kreac /kinetics/chain/kinetics[20]/CaM/CaM-Ca4/diff 0 0.001 0.001 \ "" white black 1009 -5 0 simundump kreac /kinetics/chain/kinetics[20]/Ras-act-unphosph-raf 0 7.958e-05 \ 1 "" white black 1020 -4 0 simundump kpool /kinetics/chain/kinetics[20]/Ca_input 0 -1e-12 0.08 0.08 \ 6031.7 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 994 -7 0 simundump kreac /kinetics/chain/kinetics[20]/Ca_diff 0 2 2 "" white black 995 \ -12 0 simundump group /kinetics/chain/kinetics[21] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 1054 0 0 simundump group /kinetics/chain/kinetics[21]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 1063 -3.7837 0 simundump kpool /kinetics/chain/kinetics[21]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 1061.9 -10.489 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 1062.9 -7.489 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 1061.9 -12.123 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 1063.9 -11.306 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 1062.2 -7.7467 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 1063.4 -9.2638 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca-AA 0 \ 1.5916e-08 0.1 "" white blue 1065.2 -8.1843 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-act-by-DAG-AA 0 2 0.2 "" \ white blue 1067.2 -8.7678 0 simundump kpool /kinetics/chain/kinetics[21]/PKC/PKC-DAG-AA* 0 -1e-12 \ 4.9137e-18 4.9137e-18 3.7047e-13 3.7047e-13 0 0 75396 0 /kinetics/dendgeom \ cyan blue 1066.6 -6.463 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-DAG-AA*/diff 0 0.001 \ 0.001 "" white black 1067.6 -3.463 0 simundump kpool /kinetics/chain/kinetics[21]/PKC/PKC-Ca-AA* 0 -1e-12 \ 1.7501e-16 1.7501e-16 1.3195e-11 1.3195e-11 0 0 75396 0 /kinetics/dendgeom \ orange blue 1065.4 -5.7044 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-Ca-AA*/diff 0 0.001 \ 0.001 "" white black 1066.4 -2.7044 0 simundump kpool /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb* 0 -1e-12 \ 1.3896e-17 1.3896e-17 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom \ pink blue 1063.2 -5.471 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb*/diff 0 0.001 \ 0.001 "" white black 1064.2 -2.471 0 simundump kpool /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb* 0 -1e-12 \ 9.4351e-21 9.4351e-21 7.1137e-16 7.1137e-16 0 0 75396 0 /kinetics/dendgeom \ yellow blue 1064.2 -6.4922 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb*/diff 0 0.001 \ 0.001 "" white black 1065.2 -3.4922 0 simundump kpool /kinetics/chain/kinetics[21]/PKC/PKC-basal* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 1061.3 -6.4338 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-basal*/diff 0 0.001 \ 0.001 "" white black 1062.3 -3.4338 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-basal-act 0 1 50 "" \ white blue 1061 -8.9429 0 simundump kpool /kinetics/chain/kinetics[21]/PKC/PKC-AA* 0 -1e-12 1.8134e-17 \ 1.8134e-17 1.3672e-12 1.3672e-12 0 0 75396 0 /kinetics/dendgeom cyan blue \ 1067.8 -5.1793 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-AA*/diff 0 0.001 0.001 \ "" white black 1068.8 -2.1793 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-act-by-AA 0 1.5916e-09 \ 0.1 "" white blue 1061 -13.865 0 simundump kpool /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG 0 -1e-12 \ 8.4632e-23 8.4632e-23 6.3809e-18 6.3809e-18 0 0 75396 0 /kinetics/dendgeom \ white blue 1066.2 -10.197 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG/diff 0 0.001 \ 0.001 "" white black 1067.2 -7.197 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 1063 -13.99 0 simundump kpool /kinetics/chain/kinetics[21]/PKC/PKC-DAG 0 -1e-12 1.161e-16 \ 1.161e-16 8.7535e-12 8.7535e-12 0 0 75396 0 /kinetics/dendgeom white blue \ 1065 -13.086 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-DAG/diff 0 0.001 0.001 \ "" white black 1066 -10.086 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG-AA 0 2.3874e-07 2 \ "" white blue 1064.8 -14.953 0 simundump kpool /kinetics/chain/kinetics[21]/PKC/PKC-DAG-AA 0 -1e-12 \ 2.5188e-19 2.5188e-19 1.8991e-14 1.8991e-14 0 0 75396 0 /kinetics/dendgeom \ white blue 1066.6 -11.773 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-DAG-AA/diff 0 0.001 \ 0.001 "" white black 1067.6 -8.773 0 simundump kpool /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic 0 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom white blue 1059.9 -11.403 0 simundump kreac /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic/diff 0 0.001 \ 0.001 "" white black 1060.9 -8.403 0 simundump kpool /kinetics/chain/kinetics[21]/AA 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom darkgreen black 1062.7 -21.338 0 simundump kreac /kinetics/chain/kinetics[21]/AA/diff 0 0.001 0.001 "" white \ black 1063.7 -18.338 0 simundump group /kinetics/chain/kinetics[21]/PLA2 0 darkgreen black x 0 1 "" \ defaultfile defaultfile.g 0 0 0 1058.6 -26.209 0 simundump kpool /kinetics/chain/kinetics[21]/PLA2/PLA2-cytosolic 0 -1e-12 \ 0.39999 0.39999 30158 30158 0 0 75396 0 /kinetics/dendgeom yellow darkgreen \ 1054.2 -20.942 0 simundump kreac /kinetics/chain/kinetics[21]/PLA2/PLA2-cytosolic/diff 0 0.001 \ 0.001 "" white black 1055.2 -17.942 0 simundump kreac /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca-act 0 1.3263e-05 \ 0.1 "" white darkgreen 1054.9 -23.104 0 simundump kpool /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom yellow darkgreen 1057.3 -23.646 0 simundump kenz /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca*/kenz 0 0 0 0 0 \ 75396 1.7906e-05 21.6 5.4 0 0 "" red yellow "" 1059.9 -23.667 0 simundump kreac /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca*/diff 0 0.001 0.001 \ "" white black 1058.3 -20.646 0 simundump kreac /kinetics/chain/kinetics[21]/PLA2/PIP2-PLA2-act 0 1.5916e-08 \ 0.5 "" white darkgreen 1054.9 -18.75 0 simundump kpool /kinetics/chain/kinetics[21]/PLA2/PIP2-PLA2* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 1057.3 -18.292 0 simundump kenz /kinetics/chain/kinetics[21]/PLA2/PIP2-PLA2*/kenz 0 0 0 0 0 \ 75396 3.6607e-05 44.16 11.04 0 0 "" red cyan "" 1060 -18.271 0 simundump kreac /kinetics/chain/kinetics[21]/PLA2/PIP2-PLA2*/diff 0 0.001 \ 0.001 "" white black 1058.3 -15.292 0 simundump kreac /kinetics/chain/kinetics[21]/PLA2/PIP2-Ca-PLA2-act 0 \ 1.5916e-07 0.1 "" white darkgreen 1055.9 -19.5 0 simundump kpool /kinetics/chain/kinetics[21]/PLA2/PIP2-Ca-PLA2* 0 -1e-12 0 0 \ 0 0 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 1057.7 -19.896 0 simundump kenz /kinetics/chain/kinetics[21]/PLA2/PIP2-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00011937 144 36 0 0 "" red cyan "" 1060 -19.979 0 simundump kreac /kinetics/chain/kinetics[21]/PLA2/PIP2-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 1058.7 -16.896 0 simundump kreac /kinetics/chain/kinetics[21]/PLA2/DAG-Ca-PLA2-act 0 3.979e-08 \ 4 "" white darkgreen 1055.2 -21.834 0 simundump kpool /kinetics/chain/kinetics[21]/PLA2/DAG-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom pink darkgreen 1057.9 -22.479 0 simundump kenz /kinetics/chain/kinetics[21]/PLA2/DAG-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00019895 240 60 0 0 "" red pink "" 1060 -22.354 0 simundump kreac /kinetics/chain/kinetics[21]/PLA2/DAG-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 1058.9 -19.479 0 simundump kpool /kinetics/chain/kinetics[21]/PLA2/APC 0 -1e-12 30 30 \ 2.2619e+06 2.2619e+06 0 0 75396 4 /kinetics/dendgeom yellow darkgreen \ 1057.8 -21.963 0 simundump kreac /kinetics/chain/kinetics[21]/PLA2/Degrade-AA 1 0.4 0 "" white \ darkgreen 1059.8 -17.288 0 simundump kpool /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange darkgreen 1058.2 -24.687 0 simundump kenz /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca/kenz 0 0 0 0 0 \ 75396 0.0003979 480 120 0 0 "" red orange "" 1059.9 -24.817 0 simundump kreac /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca/diff 0 0.001 0.001 \ "" white black 1059.2 -21.687 0 simundump kpool /kinetics/chain/kinetics[21]/PLA2/PLA2* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange darkgreen 1057 -26.851 0 simundump kreac /kinetics/chain/kinetics[21]/PLA2/PLA2*/diff 0 0.001 0.001 "" \ white black 1058 -23.851 0 simundump kreac /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca-act 1 7.958e-05 \ 0.1 "" white darkgreen 1055.9 -24.752 0 simundump kreac /kinetics/chain/kinetics[21]/PLA2/dephosphorylate-PLA2* 1 \ 0.17 0 "" white darkgreen 1052.3 -23.735 0 simundump kpool /kinetics/chain/kinetics[21]/temp-PIP2 1 -1e-12 2.5 2.5 \ 1.8849e+05 1.8849e+05 0 0 75396 4 /kinetics/dendgeom green black 1050.2 \ -19.047 0 simundump group /kinetics/chain/kinetics[21]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 1081 -1 0 simundump kpool /kinetics/chain/kinetics[21]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 1072 -4 0 simundump kpool /kinetics/chain/kinetics[21]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 1075 -4 0 simundump kpool /kinetics/chain/kinetics[21]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 1072 -8 0 simundump kpool /kinetics/chain/kinetics[21]/MAPK/MAPK 0 -1e-12 3.5999 3.5999 \ 2.7142e+05 2.7142e+05 0 0 75396 0 /kinetics/dendgeom pink brown 1072 -11 0 simundump kreac /kinetics/chain/kinetics[21]/MAPK/MAPK/diff 0 0.001 0.001 "" \ white black 1073 -8 0 simundump kpool /kinetics/chain/kinetics[21]/MAPK/craf-1** 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink brown 1078 -4 0 simundump kpool /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr 1 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange brown 1075 -11 0 simundump kreac /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr/diff 0 0.001 0.001 \ "" white black 1076 -8 0 simundump kpool /kinetics/chain/kinetics[21]/MAPK/MAPKK* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 1079 -8 0 simundump kenz /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 1074 -9 0 simundump kenz /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 1079 -9 0 simundump kpool /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 1075 -8 0 simundump kpool /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 1071 -6 0 simundump kenz /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 1074 -6 0 simundump kenz /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 1077 -6 0 simundump kpool /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom red brown 1071 -7 0 simundump kenz /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 1074 -7 0 simundump kenz /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 1077 -7 0 simundump kreac /kinetics/chain/kinetics[21]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 1069 -3 0 simundump group /kinetics/chain/kinetics[21]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 1080.5 4.351 0 simundump kreac /kinetics/chain/kinetics[21]/Ras/dephosph-GEF 1 1 0 "" white \ blue 1075.1 5.881 0 simundump kpool /kinetics/chain/kinetics[21]/Ras/inact-GEF 1 -1e-12 0.1 0.1 \ 7539.6 7539.6 0 0 75396 0 /kinetics/dendgeom hotpink blue 1078.5 6.352 0 simundump kenz /kinetics/chain/kinetics[21]/Ras/inact-GEF/basal_GEF_activity 0 \ 0 0 0 0 75396 1.313e-07 0.08 0.02 0 0 "" red hotpink "" 1077 5 0 simundump kreac /kinetics/chain/kinetics[21]/Ras/inact-GEF/diff 0 0.001 0.001 \ "" white black 1079.5 9.352 0 simundump kpool /kinetics/chain/kinetics[21]/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 1072.4 5.246 0 simundump kenz /kinetics/chain/kinetics[21]/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 \ 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 1073.1 4.086 0 simundump kreac /kinetics/chain/kinetics[21]/Ras/GEF*/diff 0 0.001 0.001 "" \ white black 1073.4 8.246 0 simundump kpool /kinetics/chain/kinetics[21]/Ras/GTP-Ras 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange blue 1078.6 1.084 0 simundump kpool /kinetics/chain/kinetics[21]/Ras/GDP-Ras 1 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink blue 1072.1 2.165 0 simundump kreac /kinetics/chain/kinetics[21]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 1075.1 1.5 0 simundump kreac /kinetics/chain/kinetics[21]/Ras/dephosph-GAP 1 0.1 0 "" \ white blue 1070 3.524 0 simundump kpool /kinetics/chain/kinetics[21]/Ras/GAP* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red blue 1067.3 2.349 0 simundump kreac /kinetics/chain/kinetics[21]/Ras/GAP*/diff 0 0.001 0.001 "" \ white black 1068.3 5.349 0 simundump kpool /kinetics/chain/kinetics[21]/Ras/GAP 1 -1e-12 0.01 0.01 \ 753.96 753.96 0 0 75396 0 /kinetics/dendgeom red blue 1072.7 0.338 0 simundump kenz /kinetics/chain/kinetics[21]/Ras/GAP/GAP-inact-ras 1 0 0 0 0 \ 75396 0.00065634 40 10 0 0 "" red red "" 1075 0.403 0 simundump kreac /kinetics/chain/kinetics[21]/Ras/GAP/diff 0 0.001 0.001 "" \ white black 1073.7 3.338 0 simundump kreac /kinetics/chain/kinetics[21]/Ras/CaM-bind-GEF 1 0.0026526 1 \ "" white blue 1068.5 9.679 0 simundump kpool /kinetics/chain/kinetics[21]/Ras/CaM-GEF 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 1071.3 7.58 0 simundump kenz /kinetics/chain/kinetics[21]/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 \ 0 0 75396 1.3131e-05 0.4 0.1 0 0 "" red pink "" 1071 6.657 0 simundump kreac /kinetics/chain/kinetics[21]/Ras/CaM-GEF/diff 0 0.001 0.001 \ "" white black 1072.3 10.58 0 simundump kpool /kinetics/chain/kinetics[21]/Ca 1 -1e-12 0.095 0.095 7162.6 \ 7162.6 0 0 75396 4 /kinetics/dendgeom red black 1051 -13 0 simundump kpool /kinetics/chain/kinetics[21]/DAG 1 -1e-12 12.2 12.2 \ 9.1983e+05 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 1066.7 \ -19.562 0 simundump kpool /kinetics/chain/kinetics[21]/PKC-active 1 -1e-12 0.3 \ 2.1196e-16 1.5981e-11 22619 0 0 75396 2 /kinetics/dendgeom red black 1066 \ -3 0 simundump kenz /kinetics/chain/kinetics[21]/PKC-active/PKC-act-raf 1 0 0 0 0 \ 75396 3.979e-06 16 4 0 0 "" red yellow "" 1072 -2 0 simundump kenz /kinetics/chain/kinetics[21]/PKC-active/PKC-inact-GAP 1 0 0 0 \ 0 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 1070 1 0 simundump kenz /kinetics/chain/kinetics[21]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 1075 8 0 simundump kenz /kinetics/chain/kinetics[21]/PKC-active/phosph-AC2 1 0 0 0 0 \ 75396 0.00066667 16 4 0 0 "" red red "" 1059.3 -23.269 0 simundump kpool /kinetics/chain/kinetics[21]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 1079 -11 0 simundump kenz /kinetics/chain/kinetics[21]/MAPK*/MAPK* 0 0 0 0 0 75396 \ 2.5864e-05 40 10 0 0 "" red orange "" 1054 -26 0 simundump kenz /kinetics/chain/kinetics[21]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange "" 1076 -2 0 simundump kreac /kinetics/chain/kinetics[21]/MAPK*/diff 0 0.001 0.001 "" \ white black 1080 -8 0 simundump kpool /kinetics/chain/kinetics[21]/IP3 1 -1e-12 0.73 0.73 55039 \ 55039 0 0 75396 4 /kinetics/dendgeom pink black 1065.2 -16.656 0 simundump kpool /kinetics/chain/kinetics[21]/MKP-1 1 -1e-12 0.024 0.024 \ 1809.5 1809.5 0 0 75396 0 /kinetics/dendgeom hotpink black 1071 -10 0 simundump kenz /kinetics/chain/kinetics[21]/MKP-1/MKP1-tyr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 1072 -9 0 simundump kenz /kinetics/chain/kinetics[21]/MKP-1/MKP1-thr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 1077 -9 0 simundump kreac /kinetics/chain/kinetics[21]/MKP-1/diff 0 0.001 0.001 "" \ white black 1072 -7 0 simundump kpool /kinetics/chain/kinetics[21]/PPhosphatase2A 1 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom hotpink yellow 1075 -3 0 simundump kenz /kinetics/chain/kinetics[21]/PPhosphatase2A/craf-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 1074 -2 0 simundump kenz /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 1077 -5 0 simundump kenz /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph-ser 1 0 \ 0 0 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 1074 -5 0 simundump kenz /kinetics/chain/kinetics[21]/PPhosphatase2A/craf**-deph 1 0 0 \ 0 0 0.12566 2.5414e-05 24 6 0 0 "" red hotpink "" 1078 -2 0 simundump kreac /kinetics/chain/kinetics[21]/PPhosphatase2A/diff 0 0.001 \ 0.001 "" white black 1076 0 0 simundump group /kinetics/chain/kinetics[21]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 1053 -9 0 simundump kpool /kinetics/chain/kinetics[21]/CaM/CaM 1 -1e-12 20 20 \ 1.5079e+06 1.5079e+06 0 0 75396 0 /kinetics/dendgeom pink blue 1053 -1.28 0 simundump kreac /kinetics/chain/kinetics[21]/CaM/CaM/diff 0 0.001 0.001 "" \ white black 1054 1.72 0 simundump kreac /kinetics/chain/kinetics[21]/CaM/CaM-TR2-bind-Ca 1 1.2666e-08 \ 72 "" white blue 1055.2 -1.921 0 simundump kreac /kinetics/chain/kinetics[21]/CaM/CaM-TR2-Ca2-bind-Ca 1 \ 4.7748e-05 10 "" white blue 1054.2 -3.7747 0 simundump kreac /kinetics/chain/kinetics[21]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 1052.6 -6.7404 0 simundump kpool /kinetics/chain/kinetics[21]/CaM/CaM-Ca3 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 1056.5 -5.603 0 simundump kreac /kinetics/chain/kinetics[21]/CaM/CaM-Ca3/diff 0 0.001 0.001 \ "" white black 1057.5 -2.603 0 simundump kpool /kinetics/chain/kinetics[21]/CaM/CaM-TR2-Ca2 1 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 1058 -2.7423 0 simundump kreac /kinetics/chain/kinetics[21]/CaM/CaM-TR2-Ca2/diff 0 0.001 \ 0.001 "" white black 1059 0.2577 0 simundump kpool /kinetics/chain/kinetics[21]/CaM/CaM-Ca4 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom blue blue 1058 -8 0 simundump kreac /kinetics/chain/kinetics[21]/CaM/CaM-Ca4/diff 0 0.001 0.001 \ "" white black 1059 -5 0 simundump kreac /kinetics/chain/kinetics[21]/Ras-act-unphosph-raf 0 7.958e-05 \ 1 "" white black 1070 -4 0 simundump kpool /kinetics/chain/kinetics[21]/Ca_input 0 -1e-12 0.08 0.08 \ 6031.7 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 1044 -7 0 simundump kreac /kinetics/chain/kinetics[21]/Ca_diff 0 2 2 "" white black \ 1045 -12 0 simundump group /kinetics/chain/kinetics[22] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 1104 0 0 simundump group /kinetics/chain/kinetics[22]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 1113 -3.7837 0 simundump kpool /kinetics/chain/kinetics[22]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 1111.9 -10.489 0 simundump kreac /kinetics/chain/kinetics[22]/PKC/PKC-Ca/diff 0 0.001 0.001 "" \ white black 1112.9 -7.489 0 simundump kreac /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 1111.9 -12.123 0 simundump kreac /kinetics/chain/kinetics[22]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 1113.9 -11.306 0 simundump kreac /kinetics/chain/kinetics[22]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 1112.2 -7.7467 0 simundump kreac /kinetics/chain/kinetics[22]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 1113.4 -9.2638 0 simundump kreac /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca-AA 0 \ 1.5916e-08 0.1 "" white blue 1115.2 -8.1843 0 simundump kreac /kinetics/chain/kinetics[22]/PKC/PKC-act-by-DAG-AA 0 2 0.2 "" \ white blue 1117.2 -8.7678 0 simundump kpool /kinetics/chain/kinetics[22]/PKC/PKC-DAG-AA* 0 -1e-12 \ 4.9137e-18 4.9137e-18 3.7047e-13 3.7047e-13 0 0 75396 0 /kinetics/dendgeom \ cyan blue 1116.6 -6.463 0 simundump kreac /kinetics/chain/kinetics[22]/PKC/PKC-DAG-AA*/diff 0 0.001 \ 0.001 "" white black 1117.6 -3.463 0 simundump kpool /kinetics/chain/kinetics[22]/PKC/PKC-Ca-AA* 0 -1e-12 \ 1.7501e-16 1.7501e-16 1.3195e-11 1.3195e-11 0 0 75396 0 /kinetics/dendgeom \ orange blue 1115.4 -5.7044 0 simundump kreac /kinetics/chain/kinetics[22]/PKC/PKC-Ca-AA*/diff 0 0.001 \ 0.001 "" white black 1116.4 -2.7044 0 simundump kpool /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb* 0 -1e-12 \ 1.3896e-17 1.3896e-17 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom \ pink blue 1113.2 -5.471 0 simundump kreac /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb*/diff 0 0.001 \ 0.001 "" white black 1114.2 -2.471 0 simundump kpool /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb* 0 -1e-12 \ 9.4351e-21 9.4351e-21 7.1137e-16 7.1137e-16 0 0 75396 0 /kinetics/dendgeom \ yellow blue 1114.2 -6.4922 0 simundump kreac /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb*/diff 0 0.001 \ 0.001 "" white black 1115.2 -3.4922 0 simundump kpool /kinetics/chain/kinetics[22]/PKC/PKC-basal* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 1111.3 -6.4338 0 simundump kreac /kinetics/chain/kinetics[22]/PKC/PKC-basal*/diff 0 0.001 \ 0.001 "" white black 1112.3 -3.4338 0 simundump kreac /kinetics/chain/kinetics[22]/PKC/PKC-basal-act 0 1 50 "" \ white blue 1111 -8.9429 0 simundump kpool /kinetics/chain/kinetics[22]/PKC/PKC-AA* 0 -1e-12 1.8134e-17 \ 1.8134e-17 1.3672e-12 1.3672e-12 0 0 75396 0 /kinetics/dendgeom cyan blue \ 1117.8 -5.1793 0 simundump kreac /kinetics/chain/kinetics[22]/PKC/PKC-AA*/diff 0 0.001 0.001 \ "" white black 1118.8 -2.1793 0 simundump kreac /kinetics/chain/kinetics[22]/PKC/PKC-act-by-AA 0 1.5916e-09 \ 0.1 "" white blue 1111 -13.865 0 simundump kpool /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG 0 -1e-12 \ 8.4632e-23 8.4632e-23 6.3809e-18 6.3809e-18 0 0 75396 0 /kinetics/dendgeom \ white blue 1116.2 -10.197 0 simundump kreac /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG/diff 0 0.001 \ 0.001 "" white black 1117.2 -7.197 0 simundump kreac /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 1113 -13.99 0 simundump kpool /kinetics/chain/kinetics[22]/PKC/PKC-DAG 0 -1e-12 1.161e-16 \ 1.161e-16 8.7535e-12 8.7535e-12 0 0 75396 0 /kinetics/dendgeom white blue \ 1115 -13.086 0 simundump kreac /kinetics/chain/kinetics[22]/PKC/PKC-DAG/diff 0 0.001 0.001 \ "" white black 1116 -10.086 0 simundump kreac /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG-AA 0 2.3874e-07 2 \ "" white blue 1114.8 -14.953 0 simundump kpool /kinetics/chain/kinetics[22]/PKC/PKC-DAG-AA 0 -1e-12 \ 2.5188e-19 2.5188e-19 1.8991e-14 1.8991e-14 0 0 75396 0 /kinetics/dendgeom \ white blue 1116.6 -11.773 0 simundump kreac /kinetics/chain/kinetics[22]/PKC/PKC-DAG-AA/diff 0 0.001 \ 0.001 "" white black 1117.6 -8.773 0 simundump kpool /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic 0 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom white blue 1109.9 -11.403 0 simundump kreac /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic/diff 0 0.001 \ 0.001 "" white black 1110.9 -8.403 0 simundump kpool /kinetics/chain/kinetics[22]/AA 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom darkgreen black 1112.7 -21.338 0 simundump kreac /kinetics/chain/kinetics[22]/AA/diff 0 0.001 0.001 "" white \ black 1113.7 -18.338 0 simundump group /kinetics/chain/kinetics[22]/PLA2 0 darkgreen black x 0 1 "" \ defaultfile defaultfile.g 0 0 0 1108.6 -26.209 0 simundump kpool /kinetics/chain/kinetics[22]/PLA2/PLA2-cytosolic 0 -1e-12 \ 0.39999 0.39999 30158 30158 0 0 75396 0 /kinetics/dendgeom yellow darkgreen \ 1104.2 -20.942 0 simundump kreac /kinetics/chain/kinetics[22]/PLA2/PLA2-cytosolic/diff 0 0.001 \ 0.001 "" white black 1105.2 -17.942 0 simundump kreac /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca-act 0 1.3263e-05 \ 0.1 "" white darkgreen 1104.9 -23.104 0 simundump kpool /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom yellow darkgreen 1107.3 -23.646 0 simundump kenz /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca*/kenz 0 0 0 0 0 \ 75396 1.7906e-05 21.6 5.4 0 0 "" red yellow "" 1109.9 -23.667 0 simundump kreac /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca*/diff 0 0.001 0.001 \ "" white black 1108.3 -20.646 0 simundump kreac /kinetics/chain/kinetics[22]/PLA2/PIP2-PLA2-act 0 1.5916e-08 \ 0.5 "" white darkgreen 1104.9 -18.75 0 simundump kpool /kinetics/chain/kinetics[22]/PLA2/PIP2-PLA2* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 1107.3 -18.292 0 simundump kenz /kinetics/chain/kinetics[22]/PLA2/PIP2-PLA2*/kenz 0 0 0 0 0 \ 75396 3.6607e-05 44.16 11.04 0 0 "" red cyan "" 1110 -18.271 0 simundump kreac /kinetics/chain/kinetics[22]/PLA2/PIP2-PLA2*/diff 0 0.001 \ 0.001 "" white black 1108.3 -15.292 0 simundump kreac /kinetics/chain/kinetics[22]/PLA2/PIP2-Ca-PLA2-act 0 \ 1.5916e-07 0.1 "" white darkgreen 1105.9 -19.5 0 simundump kpool /kinetics/chain/kinetics[22]/PLA2/PIP2-Ca-PLA2* 0 -1e-12 0 0 \ 0 0 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 1107.7 -19.896 0 simundump kenz /kinetics/chain/kinetics[22]/PLA2/PIP2-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00011937 144 36 0 0 "" red cyan "" 1110 -19.979 0 simundump kreac /kinetics/chain/kinetics[22]/PLA2/PIP2-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 1108.7 -16.896 0 simundump kreac /kinetics/chain/kinetics[22]/PLA2/DAG-Ca-PLA2-act 0 3.979e-08 \ 4 "" white darkgreen 1105.2 -21.834 0 simundump kpool /kinetics/chain/kinetics[22]/PLA2/DAG-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom pink darkgreen 1107.9 -22.479 0 simundump kenz /kinetics/chain/kinetics[22]/PLA2/DAG-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00019895 240 60 0 0 "" red pink "" 1110 -22.354 0 simundump kreac /kinetics/chain/kinetics[22]/PLA2/DAG-Ca-PLA2*/diff 0 0.001 \ 0.001 "" white black 1108.9 -19.479 0 simundump kpool /kinetics/chain/kinetics[22]/PLA2/APC 0 -1e-12 30 30 \ 2.2619e+06 2.2619e+06 0 0 75396 4 /kinetics/dendgeom yellow darkgreen \ 1107.8 -21.963 0 simundump kreac /kinetics/chain/kinetics[22]/PLA2/Degrade-AA 1 0.4 0 "" white \ darkgreen 1109.8 -17.288 0 simundump kpool /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange darkgreen 1108.2 -24.687 0 simundump kenz /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca/kenz 0 0 0 0 0 \ 75396 0.0003979 480 120 0 0 "" red orange "" 1109.9 -24.817 0 simundump kreac /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca/diff 0 0.001 0.001 \ "" white black 1109.2 -21.687 0 simundump kpool /kinetics/chain/kinetics[22]/PLA2/PLA2* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange darkgreen 1107 -26.851 0 simundump kreac /kinetics/chain/kinetics[22]/PLA2/PLA2*/diff 0 0.001 0.001 "" \ white black 1108 -23.851 0 simundump kreac /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca-act 1 7.958e-05 \ 0.1 "" white darkgreen 1105.9 -24.752 0 simundump kreac /kinetics/chain/kinetics[22]/PLA2/dephosphorylate-PLA2* 1 \ 0.17 0 "" white darkgreen 1102.3 -23.735 0 simundump kpool /kinetics/chain/kinetics[22]/temp-PIP2 1 -1e-12 2.5 2.5 \ 1.8849e+05 1.8849e+05 0 0 75396 4 /kinetics/dendgeom green black 1100.2 \ -19.047 0 simundump group /kinetics/chain/kinetics[22]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 1131 -1 0 simundump kpool /kinetics/chain/kinetics[22]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 1122 -4 0 simundump kpool /kinetics/chain/kinetics[22]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 1125 -4 0 simundump kpool /kinetics/chain/kinetics[22]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 1122 -8 0 simundump kpool /kinetics/chain/kinetics[22]/MAPK/MAPK 0 -1e-12 3.5999 3.5999 \ 2.7142e+05 2.7142e+05 0 0 75396 0 /kinetics/dendgeom pink brown 1122 -11 0 simundump kreac /kinetics/chain/kinetics[22]/MAPK/MAPK/diff 0 0.001 0.001 "" \ white black 1123 -8 0 simundump kpool /kinetics/chain/kinetics[22]/MAPK/craf-1** 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink brown 1128 -4 0 simundump kpool /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr 1 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange brown 1125 -11 0 simundump kreac /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr/diff 0 0.001 0.001 \ "" white black 1126 -8 0 simundump kpool /kinetics/chain/kinetics[22]/MAPK/MAPKK* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 1129 -8 0 simundump kenz /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 1124 -9 0 simundump kenz /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 1129 -9 0 simundump kpool /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 1125 -8 0 simundump kpool /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 1121 -6 0 simundump kenz /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 1124 -6 0 simundump kenz /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 1127 -6 0 simundump kpool /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom red brown 1121 -7 0 simundump kenz /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 1124 -7 0 simundump kenz /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 1127 -7 0 simundump kreac /kinetics/chain/kinetics[22]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 1119 -3 0 simundump group /kinetics/chain/kinetics[22]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 1130.5 4.351 0 simundump kreac /kinetics/chain/kinetics[22]/Ras/dephosph-GEF 1 1 0 "" white \ blue 1125.1 5.881 0 simundump kpool /kinetics/chain/kinetics[22]/Ras/inact-GEF 1 -1e-12 0.1 0.1 \ 7539.6 7539.6 0 0 75396 0 /kinetics/dendgeom hotpink blue 1128.5 6.352 0 simundump kenz /kinetics/chain/kinetics[22]/Ras/inact-GEF/basal_GEF_activity 0 \ 0 0 0 0 75396 1.313e-07 0.08 0.02 0 0 "" red hotpink "" 1127 5 0 simundump kreac /kinetics/chain/kinetics[22]/Ras/inact-GEF/diff 0 0.001 0.001 \ "" white black 1129.5 9.352 0 simundump kpool /kinetics/chain/kinetics[22]/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 1122.4 5.246 0 simundump kenz /kinetics/chain/kinetics[22]/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 \ 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 1123.1 4.086 0 simundump kreac /kinetics/chain/kinetics[22]/Ras/GEF*/diff 0 0.001 0.001 "" \ white black 1123.4 8.246 0 simundump kpool /kinetics/chain/kinetics[22]/Ras/GTP-Ras 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange blue 1128.6 1.084 0 simundump kpool /kinetics/chain/kinetics[22]/Ras/GDP-Ras 1 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink blue 1122.1 2.165 0 simundump kreac /kinetics/chain/kinetics[22]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 1125.1 1.5 0 simundump kreac /kinetics/chain/kinetics[22]/Ras/dephosph-GAP 1 0.1 0 "" \ white blue 1120 3.524 0 simundump kpool /kinetics/chain/kinetics[22]/Ras/GAP* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red blue 1117.3 2.349 0 simundump kreac /kinetics/chain/kinetics[22]/Ras/GAP*/diff 0 0.001 0.001 "" \ white black 1118.3 5.349 0 simundump kpool /kinetics/chain/kinetics[22]/Ras/GAP 1 -1e-12 0.01 0.01 \ 753.96 753.96 0 0 75396 0 /kinetics/dendgeom red blue 1122.7 0.338 0 simundump kenz /kinetics/chain/kinetics[22]/Ras/GAP/GAP-inact-ras 1 0 0 0 0 \ 75396 0.00065634 40 10 0 0 "" red red "" 1125 0.403 0 simundump kreac /kinetics/chain/kinetics[22]/Ras/GAP/diff 0 0.001 0.001 "" \ white black 1123.7 3.338 0 simundump kreac /kinetics/chain/kinetics[22]/Ras/CaM-bind-GEF 1 0.0026526 1 \ "" white blue 1118.5 9.679 0 simundump kpool /kinetics/chain/kinetics[22]/Ras/CaM-GEF 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 1121.3 7.58 0 simundump kenz /kinetics/chain/kinetics[22]/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 \ 0 0 75396 1.3131e-05 0.4 0.1 0 0 "" red pink "" 1121 6.657 0 simundump kreac /kinetics/chain/kinetics[22]/Ras/CaM-GEF/diff 0 0.001 0.001 \ "" white black 1122.3 10.58 0 simundump kpool /kinetics/chain/kinetics[22]/Ca 1 -1e-12 0.095 0.095 7162.6 \ 7162.6 0 0 75396 4 /kinetics/dendgeom red black 1101 -13 0 simundump kpool /kinetics/chain/kinetics[22]/DAG 1 -1e-12 12.2 12.2 \ 9.1983e+05 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 1116.7 \ -19.562 0 simundump kpool /kinetics/chain/kinetics[22]/PKC-active 1 -1e-12 0.3 \ 2.1196e-16 1.5981e-11 22619 0 0 75396 2 /kinetics/dendgeom red black 1116 \ -3 0 simundump kenz /kinetics/chain/kinetics[22]/PKC-active/PKC-act-raf 1 0 0 0 0 \ 75396 3.979e-06 16 4 0 0 "" red yellow "" 1122 -2 0 simundump kenz /kinetics/chain/kinetics[22]/PKC-active/PKC-inact-GAP 1 0 0 0 \ 0 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 1120 1 0 simundump kenz /kinetics/chain/kinetics[22]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 1125 8 0 simundump kenz /kinetics/chain/kinetics[22]/PKC-active/phosph-AC2 1 0 0 0 0 \ 75396 0.00066667 16 4 0 0 "" red red "" 1109.3 -23.269 0 simundump kpool /kinetics/chain/kinetics[22]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 1129 -11 0 simundump kenz /kinetics/chain/kinetics[22]/MAPK*/MAPK* 0 0 0 0 0 75396 \ 2.5864e-05 40 10 0 0 "" red orange "" 1104 -26 0 simundump kenz /kinetics/chain/kinetics[22]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange "" 1126 -2 0 simundump kreac /kinetics/chain/kinetics[22]/MAPK*/diff 0 0.001 0.001 "" \ white black 1130 -8 0 simundump kpool /kinetics/chain/kinetics[22]/IP3 1 -1e-12 0.73 0.73 55039 \ 55039 0 0 75396 4 /kinetics/dendgeom pink black 1115.2 -16.656 0 simundump kpool /kinetics/chain/kinetics[22]/MKP-1 1 -1e-12 0.024 0.024 \ 1809.5 1809.5 0 0 75396 0 /kinetics/dendgeom hotpink black 1121 -10 0 simundump kenz /kinetics/chain/kinetics[22]/MKP-1/MKP1-tyr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 1122 -9 0 simundump kenz /kinetics/chain/kinetics[22]/MKP-1/MKP1-thr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 1127 -9 0 simundump kreac /kinetics/chain/kinetics[22]/MKP-1/diff 0 0.001 0.001 "" \ white black 1122 -7 0 simundump kpool /kinetics/chain/kinetics[22]/PPhosphatase2A 1 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom hotpink yellow 1125 -3 0 simundump kenz /kinetics/chain/kinetics[22]/PPhosphatase2A/craf-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 1124 -2 0 simundump kenz /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 1127 -5 0 simundump kenz /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph-ser 1 0 \ 0 0 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 1124 -5 0 simundump kenz /kinetics/chain/kinetics[22]/PPhosphatase2A/craf**-deph 1 0 0 \ 0 0 0.12566 2.5414e-05 24 6 0 0 "" red hotpink "" 1128 -2 0 simundump kreac /kinetics/chain/kinetics[22]/PPhosphatase2A/diff 0 0.001 \ 0.001 "" white black 1126 0 0 simundump group /kinetics/chain/kinetics[22]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 1103 -9 0 simundump kpool /kinetics/chain/kinetics[22]/CaM/CaM 1 -1e-12 20 20 \ 1.5079e+06 1.5079e+06 0 0 75396 0 /kinetics/dendgeom pink blue 1103 -1.28 0 simundump kreac /kinetics/chain/kinetics[22]/CaM/CaM/diff 0 0.001 0.001 "" \ white black 1104 1.72 0 simundump kreac /kinetics/chain/kinetics[22]/CaM/CaM-TR2-bind-Ca 1 1.2666e-08 \ 72 "" white blue 1105.2 -1.921 0 simundump kreac /kinetics/chain/kinetics[22]/CaM/CaM-TR2-Ca2-bind-Ca 1 \ 4.7748e-05 10 "" white blue 1104.2 -3.7747 0 simundump kreac /kinetics/chain/kinetics[22]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 1102.6 -6.7404 0 simundump kpool /kinetics/chain/kinetics[22]/CaM/CaM-Ca3 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 1106.5 -5.603 0 simundump kreac /kinetics/chain/kinetics[22]/CaM/CaM-Ca3/diff 0 0.001 0.001 \ "" white black 1107.5 -2.603 0 simundump kpool /kinetics/chain/kinetics[22]/CaM/CaM-TR2-Ca2 1 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 1108 -2.7423 0 simundump kreac /kinetics/chain/kinetics[22]/CaM/CaM-TR2-Ca2/diff 0 0.001 \ 0.001 "" white black 1109 0.2577 0 simundump kpool /kinetics/chain/kinetics[22]/CaM/CaM-Ca4 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom blue blue 1108 -8 0 simundump kreac /kinetics/chain/kinetics[22]/CaM/CaM-Ca4/diff 0 0.001 0.001 \ "" white black 1109 -5 0 simundump kreac /kinetics/chain/kinetics[22]/Ras-act-unphosph-raf 0 7.958e-05 \ 1 "" white black 1120 -4 0 simundump kpool /kinetics/chain/kinetics[22]/Ca_input 0 -1e-12 0.08 0.08 \ 6031.7 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 1094 -7 0 simundump kreac /kinetics/chain/kinetics[22]/Ca_diff 0 2 2 "" white black \ 1095 -12 0 simundump group /kinetics/chain/kinetics[23] 0 yellow black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 1154 0 0 simundump group /kinetics/chain/kinetics[23]/PKC 0 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 1163 -3.7837 0 simundump kpool /kinetics/chain/kinetics[23]/PKC/PKC-Ca 0 -1e-12 3.7208e-17 \ 3.7208e-17 2.8053e-12 2.8053e-12 0 0 75396 0 /kinetics/dendgeom red black \ 1161.9 -10.489 0 simundump kreac /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca 0 7.958e-06 \ 0.5 "" white blue 1161.9 -12.123 0 simundump kreac /kinetics/chain/kinetics[23]/PKC/PKC-act-by-DAG 0 1.061e-07 \ 8.6348 "" white blue 1163.9 -11.306 0 simundump kreac /kinetics/chain/kinetics[23]/PKC/PKC-Ca-to-memb 0 1.2705 \ 3.5026 "" white blue 1162.2 -7.7467 0 simundump kreac /kinetics/chain/kinetics[23]/PKC/PKC-DAG-to-memb 0 1 0.1 "" \ white blue 1163.4 -9.2638 0 simundump kreac /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca-AA 0 \ 1.5916e-08 0.1 "" white blue 1165.2 -8.1843 0 simundump kreac /kinetics/chain/kinetics[23]/PKC/PKC-act-by-DAG-AA 0 2 0.2 "" \ white blue 1167.2 -8.7678 0 simundump kpool /kinetics/chain/kinetics[23]/PKC/PKC-DAG-AA* 0 -1e-12 \ 4.9137e-18 4.9137e-18 3.7047e-13 3.7047e-13 0 0 75396 0 /kinetics/dendgeom \ cyan blue 1166.6 -6.463 0 simundump kpool /kinetics/chain/kinetics[23]/PKC/PKC-Ca-AA* 0 -1e-12 \ 1.7501e-16 1.7501e-16 1.3195e-11 1.3195e-11 0 0 75396 0 /kinetics/dendgeom \ orange blue 1165.4 -5.7044 0 simundump kpool /kinetics/chain/kinetics[23]/PKC/PKC-Ca-memb* 0 -1e-12 \ 1.3896e-17 1.3896e-17 1.0477e-12 1.0477e-12 0 0 75396 0 /kinetics/dendgeom \ pink blue 1163.2 -5.471 0 simundump kpool /kinetics/chain/kinetics[23]/PKC/PKC-DAG-memb* 0 -1e-12 \ 9.4351e-21 9.4351e-21 7.1137e-16 7.1137e-16 0 0 75396 0 /kinetics/dendgeom \ yellow blue 1164.2 -6.4922 0 simundump kpool /kinetics/chain/kinetics[23]/PKC/PKC-basal* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 1161.3 -6.4338 0 simundump kreac /kinetics/chain/kinetics[23]/PKC/PKC-basal-act 0 1 50 "" \ white blue 1161 -8.9429 0 simundump kpool /kinetics/chain/kinetics[23]/PKC/PKC-AA* 0 -1e-12 1.8134e-17 \ 1.8134e-17 1.3672e-12 1.3672e-12 0 0 75396 0 /kinetics/dendgeom cyan blue \ 1167.8 -5.1793 0 simundump kreac /kinetics/chain/kinetics[23]/PKC/PKC-act-by-AA 0 1.5916e-09 \ 0.1 "" white blue 1161 -13.865 0 simundump kpool /kinetics/chain/kinetics[23]/PKC/PKC-Ca-DAG 0 -1e-12 \ 8.4632e-23 8.4632e-23 6.3809e-18 6.3809e-18 0 0 75396 0 /kinetics/dendgeom \ white blue 1166.2 -10.197 0 simundump kreac /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG 0 7.958e-09 0.1 "" \ white blue 1163 -13.99 0 simundump kpool /kinetics/chain/kinetics[23]/PKC/PKC-DAG 0 -1e-12 1.161e-16 \ 1.161e-16 8.7535e-12 8.7535e-12 0 0 75396 0 /kinetics/dendgeom white blue \ 1165 -13.086 0 simundump kreac /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG-AA 0 2.3874e-07 2 \ "" white blue 1164.8 -14.953 0 simundump kpool /kinetics/chain/kinetics[23]/PKC/PKC-DAG-AA 0 -1e-12 \ 2.5188e-19 2.5188e-19 1.8991e-14 1.8991e-14 0 0 75396 0 /kinetics/dendgeom \ white blue 1166.6 -11.773 0 simundump kpool /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic 0 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom white blue 1159.9 -11.403 0 simundump kpool /kinetics/chain/kinetics[23]/AA 0 -1e-12 0 0 0 0 0 0 75396 0 \ /kinetics/dendgeom darkgreen black 1162.7 -21.338 0 simundump group /kinetics/chain/kinetics[23]/PLA2 0 darkgreen black x 0 1 "" \ defaultfile defaultfile.g 0 0 0 1158.6 -26.209 0 simundump kpool /kinetics/chain/kinetics[23]/PLA2/PLA2-cytosolic 0 -1e-12 \ 0.39999 0.39999 30158 30158 0 0 75396 0 /kinetics/dendgeom yellow darkgreen \ 1154.2 -20.942 0 simundump kreac /kinetics/chain/kinetics[23]/PLA2/PLA2-Ca-act 0 1.3263e-05 \ 0.1 "" white darkgreen 1154.9 -23.104 0 simundump kpool /kinetics/chain/kinetics[23]/PLA2/PLA2-Ca* 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom yellow darkgreen 1157.3 -23.646 0 simundump kenz /kinetics/chain/kinetics[23]/PLA2/PLA2-Ca*/kenz 0 0 0 0 0 \ 75396 1.7906e-05 21.6 5.4 0 0 "" red yellow "" 1159.9 -23.667 0 simundump kreac /kinetics/chain/kinetics[23]/PLA2/PIP2-PLA2-act 0 1.5916e-08 \ 0.5 "" white darkgreen 1154.9 -18.75 0 simundump kpool /kinetics/chain/kinetics[23]/PLA2/PIP2-PLA2* 0 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 1157.3 -18.292 0 simundump kenz /kinetics/chain/kinetics[23]/PLA2/PIP2-PLA2*/kenz 0 0 0 0 0 \ 75396 3.6607e-05 44.16 11.04 0 0 "" red cyan "" 1160 -18.271 0 simundump kreac /kinetics/chain/kinetics[23]/PLA2/PIP2-Ca-PLA2-act 0 \ 1.5916e-07 0.1 "" white darkgreen 1155.9 -19.5 0 simundump kpool /kinetics/chain/kinetics[23]/PLA2/PIP2-Ca-PLA2* 0 -1e-12 0 0 \ 0 0 0 0 75396 0 /kinetics/dendgeom cyan darkgreen 1157.7 -19.896 0 simundump kenz /kinetics/chain/kinetics[23]/PLA2/PIP2-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00011937 144 36 0 0 "" red cyan "" 1160 -19.979 0 simundump kreac /kinetics/chain/kinetics[23]/PLA2/DAG-Ca-PLA2-act 0 3.979e-08 \ 4 "" white darkgreen 1155.2 -21.834 0 simundump kpool /kinetics/chain/kinetics[23]/PLA2/DAG-Ca-PLA2* 0 -1e-12 0 0 0 \ 0 0 0 75396 0 /kinetics/dendgeom pink darkgreen 1157.9 -22.479 0 simundump kenz /kinetics/chain/kinetics[23]/PLA2/DAG-Ca-PLA2*/kenz 0 0 0 0 0 \ 75396 0.00019895 240 60 0 0 "" red pink "" 1160 -22.354 0 simundump kpool /kinetics/chain/kinetics[23]/PLA2/APC 0 -1e-12 30 30 \ 2.2619e+06 2.2619e+06 0 0 75396 4 /kinetics/dendgeom yellow darkgreen \ 1157.8 -21.963 0 simundump kreac /kinetics/chain/kinetics[23]/PLA2/Degrade-AA 1 0.4 0 "" white \ darkgreen 1159.8 -17.288 0 simundump kpool /kinetics/chain/kinetics[23]/PLA2/PLA2*-Ca 0 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange darkgreen 1158.2 -24.687 0 simundump kenz /kinetics/chain/kinetics[23]/PLA2/PLA2*-Ca/kenz 0 0 0 0 0 \ 75396 0.0003979 480 120 0 0 "" red orange "" 1159.9 -24.817 0 simundump kpool /kinetics/chain/kinetics[23]/PLA2/PLA2* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange darkgreen 1157 -26.851 0 simundump kreac /kinetics/chain/kinetics[23]/PLA2/PLA2*-Ca-act 1 7.958e-05 \ 0.1 "" white darkgreen 1155.9 -24.752 0 simundump kreac /kinetics/chain/kinetics[23]/PLA2/dephosphorylate-PLA2* 1 \ 0.17 0 "" white darkgreen 1152.3 -23.735 0 simundump kpool /kinetics/chain/kinetics[23]/temp-PIP2 1 -1e-12 2.5 2.5 \ 1.8849e+05 1.8849e+05 0 0 75396 4 /kinetics/dendgeom green black 1150.2 \ -19.047 0 simundump group /kinetics/chain/kinetics[23]/MAPK 0 brown black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 1181 -1 0 simundump kpool /kinetics/chain/kinetics[23]/MAPK/craf-1 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 1172 -4 0 simundump kpool /kinetics/chain/kinetics[23]/MAPK/craf-1* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 1175 -4 0 simundump kpool /kinetics/chain/kinetics[23]/MAPK/MAPKK 0 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink brown 1172 -8 0 simundump kpool /kinetics/chain/kinetics[23]/MAPK/MAPK 0 -1e-12 3.5999 3.5999 \ 2.7142e+05 2.7142e+05 0 0 75396 0 /kinetics/dendgeom pink brown 1172 -11 0 simundump kpool /kinetics/chain/kinetics[23]/MAPK/craf-1** 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink brown 1178 -4 0 simundump kpool /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr 1 -1e-12 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom orange brown 1175 -11 0 simundump kpool /kinetics/chain/kinetics[23]/MAPK/MAPKK* 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 1179 -8 0 simundump kenz /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKtyr 0 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 1174 -9 0 simundump kenz /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKthr 1 0 0 0 0 \ 75396 0.00042973 1.2 0.3 0 0 "" red pink "" 1179 -9 0 simundump kpool /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink brown 1175 -8 0 simundump kpool /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras 0 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom 55 brown 1171 -6 0 simundump kenz /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 1174 -6 0 simundump kenz /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 0 \ 0 0 0 0 75396 0.00012505 1.2 0.3 0 0 "" red 55 "" 1177 -6 0 simundump kpool /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras 1 0 0 0 0 0 0 \ 0 75396 0 /kinetics/dendgeom red brown 1171 -7 0 simundump kenz /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 1174 -7 0 simundump kenz /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 1 \ 0 0 0 0 0.12566 0.00012505 1.2 0.3 0 0 "" red red "" 1177 -7 0 simundump kreac /kinetics/chain/kinetics[23]/Ras-act-craf 1 0.00013263 0.5 "" \ white black 1169 -3 0 simundump group /kinetics/chain/kinetics[23]/Ras 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 1180.5 4.351 0 simundump kreac /kinetics/chain/kinetics[23]/Ras/dephosph-GEF 1 1 0 "" white \ blue 1175.1 5.881 0 simundump kpool /kinetics/chain/kinetics[23]/Ras/inact-GEF 1 -1e-12 0.1 0.1 \ 7539.6 7539.6 0 0 75396 0 /kinetics/dendgeom hotpink blue 1178.5 6.352 0 simundump kenz /kinetics/chain/kinetics[23]/Ras/inact-GEF/basal_GEF_activity 0 \ 0 0 0 0 75396 1.313e-07 0.08 0.02 0 0 "" red hotpink "" 1177 5 0 simundump kpool /kinetics/chain/kinetics[23]/Ras/GEF* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 1172.4 5.246 0 simundump kenz /kinetics/chain/kinetics[23]/Ras/GEF*/GEF*-act-ras 1 0 0 0 0 \ 75396 2.6261e-06 0.08 0.02 0 0 "" red hotpink "" 1173.1 4.086 0 simundump kpool /kinetics/chain/kinetics[23]/Ras/GTP-Ras 1 0 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom orange blue 1178.6 1.084 0 simundump kpool /kinetics/chain/kinetics[23]/Ras/GDP-Ras 1 0 0.5 0.5 37698 \ 37698 0 0 75396 0 /kinetics/dendgeom pink blue 1172.1 2.165 0 simundump kreac /kinetics/chain/kinetics[23]/Ras/Ras-intrinsic-GTPase 1 1e-04 \ 0 "" white blue 1175.1 1.5 0 simundump kreac /kinetics/chain/kinetics[23]/Ras/dephosph-GAP 1 0.1 0 "" \ white blue 1170 3.524 0 simundump kpool /kinetics/chain/kinetics[23]/Ras/GAP* 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom red blue 1167.3 2.349 0 simundump kpool /kinetics/chain/kinetics[23]/Ras/GAP 1 -1e-12 0.01 0.01 \ 753.96 753.96 0 0 75396 0 /kinetics/dendgeom red blue 1172.7 0.338 0 simundump kenz /kinetics/chain/kinetics[23]/Ras/GAP/GAP-inact-ras 1 0 0 0 0 \ 75396 0.00065634 40 10 0 0 "" red red "" 1175 0.403 0 simundump kreac /kinetics/chain/kinetics[23]/Ras/CaM-bind-GEF 1 0.0026526 1 \ "" white blue 1168.5 9.679 0 simundump kpool /kinetics/chain/kinetics[23]/Ras/CaM-GEF 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom pink blue 1171.3 7.58 0 simundump kenz /kinetics/chain/kinetics[23]/Ras/CaM-GEF/CaM-GEF-act-ras 1 0 0 \ 0 0 75396 1.3131e-05 0.4 0.1 0 0 "" red pink "" 1171 6.657 0 simundump kpool /kinetics/chain/kinetics[23]/Ca 1 -1e-12 0.095 0.095 7162.6 \ 7162.6 0 0 75396 4 /kinetics/dendgeom red black 1151 -13 0 simundump kpool /kinetics/chain/kinetics[23]/DAG 1 -1e-12 12.2 12.2 \ 9.1983e+05 9.1983e+05 0 0 75396 4 /kinetics/dendgeom green black 1166.7 \ -19.562 0 simundump kpool /kinetics/chain/kinetics[23]/PKC-active 1 -1e-12 0.3 \ 2.1196e-16 1.5981e-11 22619 0 0 75396 2 /kinetics/dendgeom red black 1166 \ -3 0 simundump kenz /kinetics/chain/kinetics[23]/PKC-active/PKC-act-raf 1 0 0 0 0 \ 75396 3.979e-06 16 4 0 0 "" red yellow "" 1172 -2 0 simundump kenz /kinetics/chain/kinetics[23]/PKC-active/PKC-inact-GAP 1 0 0 0 \ 0 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 1170 1 0 simundump kenz /kinetics/chain/kinetics[23]/PKC-active/PKC-act-GEF 1 0 0 0 0 \ 0.12566 7.958e-05 16 4 0 0 "" red yellow "" 1175 8 0 simundump kenz /kinetics/chain/kinetics[23]/PKC-active/phosph-AC2 1 0 0 0 0 \ 75396 0.00066667 16 4 0 0 "" red red "" 1159.3 -23.269 0 simundump kpool /kinetics/chain/kinetics[23]/MAPK* 1 -1e-12 0 0 0 0 0 0 75396 \ 0 /kinetics/dendgeom orange yellow 1179 -11 0 simundump kenz /kinetics/chain/kinetics[23]/MAPK*/MAPK* 0 0 0 0 0 75396 \ 2.5864e-05 40 10 0 0 "" red orange "" 1154 -26 0 simundump kenz /kinetics/chain/kinetics[23]/MAPK*/MAPK*-feedback 1 0 0 0 0 \ 75396 2.5864e-05 40 10 0 0 "" red orange "" 1176 -2 0 simundump kpool /kinetics/chain/kinetics[23]/IP3 1 -1e-12 0.73 0.73 55039 \ 55039 0 0 75396 4 /kinetics/dendgeom pink black 1165.2 -16.656 0 simundump kpool /kinetics/chain/kinetics[23]/MKP-1 1 -1e-12 0.024 0.024 \ 1809.5 1809.5 0 0 75396 0 /kinetics/dendgeom hotpink black 1171 -10 0 simundump kenz /kinetics/chain/kinetics[23]/MKP-1/MKP1-tyr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 1172 -9 0 simundump kenz /kinetics/chain/kinetics[23]/MKP-1/MKP1-thr-deph 1 0 0 0 0 \ 75396 0.0019895 16 4 0 0 "" red hotpink "" 1177 -9 0 simundump kpool /kinetics/chain/kinetics[23]/PPhosphatase2A 1 -1e-12 1 1 \ 75396 75396 0 0 75396 0 /kinetics/dendgeom hotpink yellow 1175 -3 0 simundump kenz /kinetics/chain/kinetics[23]/PPhosphatase2A/craf-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 1174 -2 0 simundump kenz /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph 1 0 0 0 \ 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 1177 -5 0 simundump kenz /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph-ser 1 0 \ 0 0 0 75396 2.5414e-05 24 6 0 0 "" red hotpink "" 1174 -5 0 simundump kenz /kinetics/chain/kinetics[23]/PPhosphatase2A/craf**-deph 1 0 0 \ 0 0 0.12566 2.5414e-05 24 6 0 0 "" red hotpink "" 1178 -2 0 simundump group /kinetics/chain/kinetics[23]/CaM 1 blue black x 0 0 "" \ defaultfile defaultfile.g 0 0 0 1153 -9 0 simundump kpool /kinetics/chain/kinetics[23]/CaM/CaM 1 -1e-12 20 20 \ 1.5079e+06 1.5079e+06 0 0 75396 0 /kinetics/dendgeom pink blue 1153 -1.28 0 simundump kreac /kinetics/chain/kinetics[23]/CaM/CaM-TR2-bind-Ca 1 1.2666e-08 \ 72 "" white blue 1155.2 -1.921 0 simundump kreac /kinetics/chain/kinetics[23]/CaM/CaM-TR2-Ca2-bind-Ca 1 \ 4.7748e-05 10 "" white blue 1154.2 -3.7747 0 simundump kreac /kinetics/chain/kinetics[23]/CaM/CaM-Ca3-bind-Ca 1 6.1675e-06 \ 10 "" white blue 1152.6 -6.7404 0 simundump kpool /kinetics/chain/kinetics[23]/CaM/CaM-Ca3 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom hotpink blue 1156.5 -5.603 0 simundump kpool /kinetics/chain/kinetics[23]/CaM/CaM-TR2-Ca2 1 -1e-12 0 0 0 0 \ 0 0 75396 0 /kinetics/dendgeom pink blue 1158 -2.7423 0 simundump kpool /kinetics/chain/kinetics[23]/CaM/CaM-Ca4 1 -1e-12 0 0 0 0 0 0 \ 75396 0 /kinetics/dendgeom blue blue 1158 -8 0 simundump kreac /kinetics/chain/kinetics[23]/Ras-act-unphosph-raf 0 7.958e-05 \ 1 "" white black 1170 -4 0 simundump kpool /kinetics/chain/kinetics[23]/Ca_input 0 -1e-12 0.08 0.08 \ 6031.7 6031.7 0 0 75396 4 /kinetics/dendgeom 61 black 1144 -7 0 simundump kreac /kinetics/chain/kinetics[23]/Ca_diff 0 2 2 "" white black \ 1145 -12 0 simundump doqcsinfo /kinetics/doqcsinfo 0 Ajay_Bhalla_2007_ReacDiff3 \ Ajay_Bhalla_2007_ReacDiff3 network "Upinder S. Bhalla, NCBS" \ "Upinder S. Bhalla, NCBS" "citation here" Rat "Hippocampal CA1" Dendrite \ "Semi-Quantitative match to experiments" \ "Ajay_Bhalla_ReacDiff3 (Under Review )" "Exact GENESIS implementation" \ "Replicates original data " 0 0 0 simundump xgraph /graphs/conc1 0 0 5280.9 0 0.9 0 simundump xgraph /graphs/conc2 0 0 5280.9 0 40 0 simundump xgraph /moregraphs/conc3 0 0 5280.9 -1.1176e-08 1 0 simundump xgraph /moregraphs/conc4 0 0 5280.9 0 1 0 simundump xcoredraw /edit/draw 0 -12 1183 -28.851 12.58 simundump xtree /edit/draw/tree 0 \ /kinetics/#[],/kinetics/#[]/#[],/kinetics/#[]/#[]/#[][TYPE!=proto],/kinetics/#[]/#[]/#[][TYPE!=linkinfo]/##[] \ "edit_elm.D ; drag_from_edit.w " auto 0.6 simundump xtext /file/notes 0 1 xtextload /file/notes \ "14 Sep 2006" \ "Version for demo and paper figure. Uses parameters for" \ "active propagation. Basal Ca = 0.095 uM. D = 1e-13." \ "27 Feb 2006" \ "Version for testing Ca threshold of model. Modified with Ca_input" \ "to avoid sharp input transients." \ "28 Feb 2006: bis_PKC_MAPK_dend3.g" \ "Raised affinity of CaM and GEF 36-fold to account for Ca-input to" \ "MAPK cascade." \ "bis_PKC_MAPK_dend4.g: Set diffusion constants. Most are -1 um^2/s" \ "so as to indicate that they can be assigned to the same global" \ "value. Some are set to 0 as they are in a scaffold and probably" \ "do not diffuse much." \ "bis_PKC_MAPK_dend5.g: Speed up CaM-GEF-act-ras kcat 10x to 0.2/sec" \ "for faster MAPK response to Ca stimulus. This is in line with" \ "the PKM model. Also altered CaM affinity for CaM-GEF-act-ras" \ "downward, again in line with PKM model." \ "" addmsg /kinetics/PKC/PKC-act-by-Ca /kinetics/PKC/PKC-Ca REAC B A addmsg /kinetics/PKC/PKC-act-by-DAG /kinetics/PKC/PKC-Ca REAC A B addmsg /kinetics/PKC/PKC-Ca-to-memb /kinetics/PKC/PKC-Ca REAC A B addmsg /kinetics/PKC/PKC-act-by-Ca-AA /kinetics/PKC/PKC-Ca REAC A B addmsg /kinetics/PKC/PKC-Ca/diff /kinetics/PKC/PKC-Ca REAC A B addmsg /kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/PKC/PKC-cytosolic /kinetics/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/Ca /kinetics/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/DAG /kinetics/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/PKC/PKC-Ca-DAG /kinetics/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/PKC/PKC-Ca-memb* /kinetics/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/PKC/PKC-Ca-DAG /kinetics/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/PKC/PKC-DAG-memb* /kinetics/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/PKC/PKC-Ca /kinetics/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/AA /kinetics/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/PKC/PKC-Ca-AA* /kinetics/PKC/PKC-act-by-Ca-AA PRODUCT n addmsg /kinetics/PKC/PKC-DAG-AA* /kinetics/PKC/PKC-act-by-DAG-AA PRODUCT n addmsg /kinetics/PKC/PKC-DAG-AA /kinetics/PKC/PKC-act-by-DAG-AA SUBSTRATE n addmsg /kinetics/PKC/PKC-act-by-DAG-AA /kinetics/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/PKC/PKC-DAG-AA*/diff /kinetics/PKC/PKC-DAG-AA* REAC A B addmsg /kinetics/PKC/PKC-DAG-AA* /kinetics/PKC/PKC-DAG-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-AA* /kinetics/PKC/PKC-DAG-AA*/diff PRODUCT n addmsg /kinetics/PKC/PKC-act-by-Ca-AA /kinetics/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/PKC/PKC-Ca-AA*/diff /kinetics/PKC/PKC-Ca-AA* REAC A B addmsg /kinetics/PKC/PKC-Ca-AA* /kinetics/PKC/PKC-Ca-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-AA* /kinetics/PKC/PKC-Ca-AA*/diff PRODUCT n addmsg /kinetics/PKC/PKC-Ca-to-memb /kinetics/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/PKC/PKC-Ca-memb*/diff /kinetics/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/PKC/PKC-Ca-memb* /kinetics/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-memb* /kinetics/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/PKC/PKC-DAG-to-memb /kinetics/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/PKC/PKC-DAG-memb*/diff /kinetics/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/PKC/PKC-DAG-memb* /kinetics/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-memb* /kinetics/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/PKC/PKC-basal-act /kinetics/PKC/PKC-basal* REAC B A addmsg /kinetics/PKC/PKC-basal*/diff /kinetics/PKC/PKC-basal* REAC A B addmsg /kinetics/PKC/PKC-basal* /kinetics/PKC/PKC-basal*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-basal* /kinetics/PKC/PKC-basal*/diff PRODUCT n addmsg /kinetics/PKC/PKC-cytosolic /kinetics/PKC/PKC-basal-act SUBSTRATE n addmsg /kinetics/PKC/PKC-basal* /kinetics/PKC/PKC-basal-act PRODUCT n addmsg /kinetics/PKC/PKC-act-by-AA /kinetics/PKC/PKC-AA* REAC B A addmsg /kinetics/PKC/PKC-AA*/diff /kinetics/PKC/PKC-AA* REAC A B addmsg /kinetics/PKC/PKC-AA* /kinetics/PKC/PKC-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-AA* /kinetics/PKC/PKC-AA*/diff PRODUCT n addmsg /kinetics/AA /kinetics/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/PKC/PKC-AA* /kinetics/PKC/PKC-act-by-AA PRODUCT n addmsg /kinetics/PKC/PKC-cytosolic /kinetics/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/PKC/PKC-act-by-DAG /kinetics/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/PKC/PKC-DAG-to-memb /kinetics/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/PKC/PKC-Ca-DAG/diff /kinetics/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/PKC/PKC-Ca-DAG /kinetics/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-DAG /kinetics/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/PKC/PKC-cytosolic /kinetics/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/DAG /kinetics/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/PKC/PKC-DAG /kinetics/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/PKC/PKC-n-DAG /kinetics/PKC/PKC-DAG REAC B A addmsg /kinetics/PKC/PKC-n-DAG-AA /kinetics/PKC/PKC-DAG REAC A B addmsg /kinetics/PKC/PKC-DAG/diff /kinetics/PKC/PKC-DAG REAC A B addmsg /kinetics/PKC/PKC-DAG /kinetics/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-DAG /kinetics/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/PKC/PKC-DAG /kinetics/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/AA /kinetics/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/PKC/PKC-DAG-AA /kinetics/PKC/PKC-n-DAG-AA PRODUCT n addmsg /kinetics/PKC/PKC-n-DAG-AA /kinetics/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/PKC/PKC-act-by-DAG-AA /kinetics/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/PKC/PKC-DAG-AA/diff /kinetics/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/PKC/PKC-DAG-AA /kinetics/PKC/PKC-DAG-AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-AA /kinetics/PKC/PKC-DAG-AA/diff PRODUCT n addmsg /kinetics/PKC/PKC-act-by-Ca /kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/PKC/PKC-basal-act /kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/PKC/PKC-act-by-AA /kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/PKC/PKC-n-DAG /kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/PKC/PKC-cytosolic/diff /kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/PKC/PKC-cytosolic /kinetics/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-cytosolic /kinetics/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/PKC/PKC-act-by-Ca-AA /kinetics/AA REAC A B addmsg /kinetics/PKC/PKC-act-by-AA /kinetics/AA REAC A B addmsg /kinetics/PKC/PKC-n-DAG-AA /kinetics/AA REAC A B addmsg /kinetics/PLA2/PLA2-Ca*/kenz /kinetics/AA MM_PRD pA addmsg /kinetics/PLA2/PIP2-PLA2*/kenz /kinetics/AA MM_PRD pA addmsg /kinetics/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/AA MM_PRD pA addmsg /kinetics/PLA2/DAG-Ca-PLA2*/kenz /kinetics/AA MM_PRD pA addmsg /kinetics/PLA2/PLA2*-Ca/kenz /kinetics/AA MM_PRD pA addmsg /kinetics/PLA2/Degrade-AA /kinetics/AA REAC A B addmsg /kinetics/AA/diff /kinetics/AA REAC A B addmsg /kinetics/AA /kinetics/AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/AA /kinetics/AA/diff PRODUCT n addmsg /kinetics/PLA2/PLA2-Ca-act /kinetics/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/PLA2/PIP2-PLA2-act /kinetics/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/MAPK*/MAPK* /kinetics/PLA2/PLA2-cytosolic REAC sA B addmsg /kinetics/PLA2/dephosphorylate-PLA2* /kinetics/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/PLA2/PLA2-cytosolic/diff /kinetics/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/PLA2/PLA2-cytosolic /kinetics/PLA2/PLA2-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PLA2/PLA2-cytosolic /kinetics/PLA2/PLA2-cytosolic/diff PRODUCT n addmsg /kinetics/PLA2/PLA2-cytosolic /kinetics/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/Ca /kinetics/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/PLA2/PLA2-Ca* /kinetics/PLA2/PLA2-Ca-act PRODUCT n addmsg /kinetics/PLA2/PLA2-Ca-act /kinetics/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/PLA2/PLA2-Ca*/kenz /kinetics/PLA2/PLA2-Ca* REAC eA B addmsg /kinetics/PLA2/PIP2-Ca-PLA2-act /kinetics/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/PLA2/DAG-Ca-PLA2-act /kinetics/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/PLA2/PLA2-Ca*/diff /kinetics/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/PLA2/PLA2-Ca* /kinetics/PLA2/PLA2-Ca*/kenz ENZYME n addmsg /kinetics/PLA2/APC /kinetics/PLA2/PLA2-Ca*/kenz SUBSTRATE n addmsg /kinetics/PLA2/PLA2-Ca* /kinetics/PLA2/PLA2-Ca*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PLA2/PLA2-Ca* /kinetics/PLA2/PLA2-Ca*/diff PRODUCT n addmsg /kinetics/temp-PIP2 /kinetics/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/PLA2/PLA2-cytosolic /kinetics/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/PLA2/PIP2-PLA2* /kinetics/PLA2/PIP2-PLA2-act PRODUCT n addmsg /kinetics/PLA2/PIP2-PLA2-act /kinetics/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/PLA2/PIP2-PLA2*/kenz /kinetics/PLA2/PIP2-PLA2* REAC eA B addmsg /kinetics/PLA2/PIP2-PLA2*/diff /kinetics/PLA2/PIP2-PLA2* REAC A B addmsg /kinetics/PLA2/PIP2-PLA2* /kinetics/PLA2/PIP2-PLA2*/kenz ENZYME n addmsg /kinetics/PLA2/APC /kinetics/PLA2/PIP2-PLA2*/kenz SUBSTRATE n addmsg /kinetics/PLA2/PIP2-PLA2* /kinetics/PLA2/PIP2-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PLA2/PIP2-PLA2* /kinetics/PLA2/PIP2-PLA2*/diff PRODUCT n addmsg /kinetics/temp-PIP2 /kinetics/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/PLA2/PLA2-Ca* /kinetics/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/PLA2/PIP2-Ca-PLA2* /kinetics/PLA2/PIP2-Ca-PLA2-act PRODUCT n addmsg /kinetics/PLA2/PIP2-Ca-PLA2-act /kinetics/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/PLA2/PIP2-Ca-PLA2* REAC eA B addmsg /kinetics/PLA2/PIP2-Ca-PLA2*/diff /kinetics/PLA2/PIP2-Ca-PLA2* REAC A B addmsg /kinetics/PLA2/PIP2-Ca-PLA2* /kinetics/PLA2/PIP2-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/PLA2/APC /kinetics/PLA2/PIP2-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/PLA2/PIP2-Ca-PLA2* /kinetics/PLA2/PIP2-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PLA2/PIP2-Ca-PLA2* /kinetics/PLA2/PIP2-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/DAG /kinetics/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/PLA2/PLA2-Ca* /kinetics/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/PLA2/DAG-Ca-PLA2* /kinetics/PLA2/DAG-Ca-PLA2-act PRODUCT n addmsg /kinetics/PLA2/DAG-Ca-PLA2-act /kinetics/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/PLA2/DAG-Ca-PLA2*/kenz /kinetics/PLA2/DAG-Ca-PLA2* REAC eA B addmsg /kinetics/PLA2/DAG-Ca-PLA2*/diff /kinetics/PLA2/DAG-Ca-PLA2* REAC A B addmsg /kinetics/PLA2/DAG-Ca-PLA2* /kinetics/PLA2/DAG-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/PLA2/APC /kinetics/PLA2/DAG-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/PLA2/DAG-Ca-PLA2* /kinetics/PLA2/DAG-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PLA2/DAG-Ca-PLA2* /kinetics/PLA2/DAG-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/PLA2/PLA2-Ca*/kenz /kinetics/PLA2/APC REAC sA B addmsg /kinetics/PLA2/PIP2-PLA2*/kenz /kinetics/PLA2/APC REAC sA B addmsg /kinetics/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/PLA2/APC REAC sA B addmsg /kinetics/PLA2/DAG-Ca-PLA2*/kenz /kinetics/PLA2/APC REAC sA B addmsg /kinetics/PLA2/PLA2*-Ca/kenz /kinetics/PLA2/APC REAC sA B addmsg /kinetics/PLA2/Degrade-AA /kinetics/PLA2/APC REAC B A addmsg /kinetics/AA /kinetics/PLA2/Degrade-AA SUBSTRATE n addmsg /kinetics/PLA2/APC /kinetics/PLA2/Degrade-AA PRODUCT n addmsg /kinetics/PLA2/PLA2*-Ca/kenz /kinetics/PLA2/PLA2*-Ca REAC eA B addmsg /kinetics/PLA2/PLA2*-Ca-act /kinetics/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/PLA2/PLA2*-Ca/diff /kinetics/PLA2/PLA2*-Ca REAC A B addmsg /kinetics/PLA2/PLA2*-Ca /kinetics/PLA2/PLA2*-Ca/kenz ENZYME n addmsg /kinetics/PLA2/APC /kinetics/PLA2/PLA2*-Ca/kenz SUBSTRATE n addmsg /kinetics/PLA2/PLA2*-Ca /kinetics/PLA2/PLA2*-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PLA2/PLA2*-Ca /kinetics/PLA2/PLA2*-Ca/diff PRODUCT n addmsg /kinetics/MAPK*/MAPK* /kinetics/PLA2/PLA2* MM_PRD pA addmsg /kinetics/PLA2/PLA2*-Ca-act /kinetics/PLA2/PLA2* REAC A B addmsg /kinetics/PLA2/dephosphorylate-PLA2* /kinetics/PLA2/PLA2* REAC A B addmsg /kinetics/PLA2/PLA2*/diff /kinetics/PLA2/PLA2* REAC A B addmsg /kinetics/PLA2/PLA2* /kinetics/PLA2/PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PLA2/PLA2* /kinetics/PLA2/PLA2*/diff PRODUCT n addmsg /kinetics/PLA2/PLA2* /kinetics/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/PLA2/PLA2*-Ca /kinetics/PLA2/PLA2*-Ca-act PRODUCT n addmsg /kinetics/Ca /kinetics/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/PLA2/PLA2* /kinetics/PLA2/dephosphorylate-PLA2* SUBSTRATE n addmsg /kinetics/PLA2/PLA2-cytosolic /kinetics/PLA2/dephosphorylate-PLA2* PRODUCT n addmsg /kinetics/PLA2/PIP2-PLA2-act /kinetics/temp-PIP2 REAC A B addmsg /kinetics/PLA2/PIP2-Ca-PLA2-act /kinetics/temp-PIP2 REAC A B addmsg /kinetics/PKC-active/PKC-act-raf /kinetics/MAPK/craf-1 REAC sA B addmsg /kinetics/PPhosphatase2A/craf-deph /kinetics/MAPK/craf-1 MM_PRD pA addmsg /kinetics/Ras-act-unphosph-raf /kinetics/MAPK/craf-1 REAC A B addmsg /kinetics/PKC-active/PKC-act-raf /kinetics/MAPK/craf-1* MM_PRD pA addmsg /kinetics/MAPK*/MAPK*-feedback /kinetics/MAPK/craf-1* REAC sA B addmsg /kinetics/PPhosphatase2A/craf-deph /kinetics/MAPK/craf-1* REAC sA B addmsg /kinetics/PPhosphatase2A/craf**-deph /kinetics/MAPK/craf-1* MM_PRD pA addmsg /kinetics/Ras-act-craf /kinetics/MAPK/craf-1* REAC A B addmsg /kinetics/PPhosphatase2A/MAPKK-deph-ser /kinetics/MAPK/MAPKK MM_PRD pA addmsg /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/MAPK/MAPKK REAC sA B addmsg /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/MAPK/MAPKK REAC sA B addmsg /kinetics/MAPK/MAPKK*/MAPKKtyr /kinetics/MAPK/MAPK REAC sA B addmsg /kinetics/MKP-1/MKP1-tyr-deph /kinetics/MAPK/MAPK MM_PRD pA addmsg /kinetics/MAPK/MAPK/diff /kinetics/MAPK/MAPK REAC A B addmsg /kinetics/MAPK/MAPK /kinetics/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/MAPK /kinetics/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/MAPK*/MAPK*-feedback /kinetics/MAPK/craf-1** MM_PRD pA addmsg /kinetics/PPhosphatase2A/craf**-deph /kinetics/MAPK/craf-1** REAC sA B addmsg /kinetics/MAPK/MAPKK*/MAPKKtyr /kinetics/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/MAPK/MAPKK*/MAPKKthr /kinetics/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/MKP-1/MKP1-tyr-deph /kinetics/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/MKP-1/MKP1-thr-deph /kinetics/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/MAPK/MAPK-tyr/diff /kinetics/MAPK/MAPK-tyr REAC A B addmsg /kinetics/MAPK/MAPK-tyr /kinetics/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/MAPK-tyr /kinetics/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/MAPK/MAPKK*/MAPKKtyr /kinetics/MAPK/MAPKK* REAC eA B addmsg /kinetics/MAPK/MAPKK*/MAPKKthr /kinetics/MAPK/MAPKK* REAC eA B addmsg /kinetics/PPhosphatase2A/MAPKK-deph /kinetics/MAPK/MAPKK* REAC sA B addmsg /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/MAPK/MAPKK* /kinetics/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/MAPK/MAPK /kinetics/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/MAPK/MAPKK* /kinetics/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/MAPK/MAPK-tyr /kinetics/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/PPhosphatase2A/MAPKK-deph /kinetics/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/PPhosphatase2A/MAPKK-deph-ser /kinetics/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/Ras-act-unphosph-raf /kinetics/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/MAPK/Raf-GTP-Ras /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/MAPK/MAPKK /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/MAPK/Raf-GTP-Ras /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/MAPK/MAPKK-ser /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/Ras-act-craf /kinetics/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/MAPK/Raf*-GTP-Ras /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/MAPK/MAPKK /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/MAPK/Raf*-GTP-Ras /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/MAPK/MAPKK-ser /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/MAPK/craf-1* /kinetics/Ras-act-craf SUBSTRATE n addmsg /kinetics/Ras/GTP-Ras /kinetics/Ras-act-craf SUBSTRATE n addmsg /kinetics/MAPK/Raf*-GTP-Ras /kinetics/Ras-act-craf PRODUCT n addmsg /kinetics/Ras/GEF* /kinetics/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/Ras/inact-GEF /kinetics/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/PKC-active/PKC-act-GEF /kinetics/Ras/inact-GEF REAC sA B addmsg /kinetics/Ras/dephosph-GEF /kinetics/Ras/inact-GEF REAC B A addmsg /kinetics/Ras/CaM-bind-GEF /kinetics/Ras/inact-GEF REAC A B addmsg /kinetics/Ras/inact-GEF/basal_GEF_activity /kinetics/Ras/inact-GEF REAC eA B addmsg /kinetics/Ras/inact-GEF/diff /kinetics/Ras/inact-GEF REAC A B addmsg /kinetics/Ras/inact-GEF /kinetics/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/Ras/GDP-Ras /kinetics/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/Ras/inact-GEF /kinetics/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/inact-GEF /kinetics/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/PKC-active/PKC-act-GEF /kinetics/Ras/GEF* MM_PRD pA addmsg /kinetics/Ras/dephosph-GEF /kinetics/Ras/GEF* REAC A B addmsg /kinetics/Ras/GEF*/GEF*-act-ras /kinetics/Ras/GEF* REAC eA B addmsg /kinetics/Ras/GEF*/diff /kinetics/Ras/GEF* REAC A B addmsg /kinetics/Ras/GEF* /kinetics/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/Ras/GDP-Ras /kinetics/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/Ras/GEF* /kinetics/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/GEF* /kinetics/Ras/GEF*/diff PRODUCT n addmsg /kinetics/Ras/GAP/GAP-inact-ras /kinetics/Ras/GTP-Ras REAC sA B addmsg /kinetics/Ras/Ras-intrinsic-GTPase /kinetics/Ras/GTP-Ras REAC A B addmsg /kinetics/Ras/GEF*/GEF*-act-ras /kinetics/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/Ras-act-craf /kinetics/Ras/GTP-Ras REAC A B addmsg /kinetics/Ras-act-unphosph-raf /kinetics/Ras/GTP-Ras REAC A B addmsg /kinetics/Ras/inact-GEF/basal_GEF_activity /kinetics/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/Ras/GAP/GAP-inact-ras /kinetics/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/Ras/Ras-intrinsic-GTPase /kinetics/Ras/GDP-Ras REAC B A addmsg /kinetics/Ras/GEF*/GEF*-act-ras /kinetics/Ras/GDP-Ras REAC sA B addmsg /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/Ras/GDP-Ras REAC sA B addmsg /kinetics/Ras/inact-GEF/basal_GEF_activity /kinetics/Ras/GDP-Ras REAC sA B addmsg /kinetics/Ras/GTP-Ras /kinetics/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/Ras/GDP-Ras /kinetics/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/Ras/GAP* /kinetics/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/Ras/GAP /kinetics/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/PKC-active/PKC-inact-GAP /kinetics/Ras/GAP* MM_PRD pA addmsg /kinetics/Ras/dephosph-GAP /kinetics/Ras/GAP* REAC A B addmsg /kinetics/Ras/GAP*/diff /kinetics/Ras/GAP* REAC A B addmsg /kinetics/Ras/GAP* /kinetics/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/GAP* /kinetics/Ras/GAP*/diff PRODUCT n addmsg /kinetics/Ras/GAP/GAP-inact-ras /kinetics/Ras/GAP REAC eA B addmsg /kinetics/PKC-active/PKC-inact-GAP /kinetics/Ras/GAP REAC sA B addmsg /kinetics/Ras/dephosph-GAP /kinetics/Ras/GAP REAC B A addmsg /kinetics/Ras/GAP/diff /kinetics/Ras/GAP REAC A B addmsg /kinetics/Ras/GAP /kinetics/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/Ras/GTP-Ras /kinetics/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/Ras/GAP /kinetics/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/GAP /kinetics/Ras/GAP/diff PRODUCT n addmsg /kinetics/Ras/inact-GEF /kinetics/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/Ras/CaM-GEF /kinetics/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/CaM/CaM-Ca4 /kinetics/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/Ras/CaM-bind-GEF /kinetics/Ras/CaM-GEF REAC B A addmsg /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/Ras/CaM-GEF REAC eA B addmsg /kinetics/Ras/CaM-GEF/diff /kinetics/Ras/CaM-GEF REAC A B addmsg /kinetics/Ras/CaM-GEF /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/Ras/GDP-Ras /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/Ras/CaM-GEF /kinetics/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/CaM-GEF /kinetics/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/PKC/PKC-act-by-Ca /kinetics/Ca REAC A B addmsg /kinetics/PLA2/PLA2-Ca-act /kinetics/Ca REAC A B addmsg /kinetics/PLA2/PLA2*-Ca-act /kinetics/Ca REAC A B addmsg /kinetics/CaM/CaM-TR2-bind-Ca /kinetics/Ca REAC A B addmsg /kinetics/CaM/CaM-TR2-bind-Ca /kinetics/Ca REAC A B addmsg /kinetics/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/Ca REAC A B addmsg /kinetics/CaM/CaM-Ca3-bind-Ca /kinetics/Ca REAC A B addmsg /kinetics/Ca_diff /kinetics/Ca REAC B A addmsg /kinetics/PKC/PKC-act-by-DAG /kinetics/DAG REAC A B addmsg /kinetics/PKC/PKC-n-DAG /kinetics/DAG REAC A B addmsg /kinetics/PLA2/DAG-Ca-PLA2-act /kinetics/DAG REAC A B addmsg /kinetics/PKC/PKC-DAG-AA* /kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/PKC/PKC-Ca-memb* /kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/PKC/PKC-Ca-AA* /kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/PKC/PKC-DAG-memb* /kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/PKC/PKC-basal* /kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/PKC/PKC-AA* /kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/PKC-active/PKC-act-raf /kinetics/PKC-active REAC eA B addmsg /kinetics/PKC-active/PKC-inact-GAP /kinetics/PKC-active REAC eA B addmsg /kinetics/PKC-active/PKC-act-GEF /kinetics/PKC-active REAC eA B addmsg /kinetics/PKC-active/phosph-AC2 /kinetics/PKC-active REAC eA B addmsg /kinetics/PKC-active /kinetics/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/MAPK/craf-1 /kinetics/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/PKC-active /kinetics/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/Ras/GAP /kinetics/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/PKC-active /kinetics/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/Ras/inact-GEF /kinetics/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/PKC-active /kinetics/PKC-active/phosph-AC2 ENZYME n addmsg /kinetics/MAPK*/MAPK* /kinetics/MAPK* REAC eA B addmsg /kinetics/MAPK*/MAPK*-feedback /kinetics/MAPK* REAC eA B addmsg /kinetics/MAPK/MAPKK*/MAPKKthr /kinetics/MAPK* MM_PRD pA addmsg /kinetics/MKP-1/MKP1-thr-deph /kinetics/MAPK* REAC sA B addmsg /kinetics/MAPK*/diff /kinetics/MAPK* REAC A B addmsg /kinetics/MAPK* /kinetics/MAPK*/MAPK* ENZYME n addmsg /kinetics/PLA2/PLA2-cytosolic /kinetics/MAPK*/MAPK* SUBSTRATE n addmsg /kinetics/MAPK* /kinetics/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/MAPK/craf-1* /kinetics/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/MAPK* /kinetics/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK* /kinetics/MAPK*/diff PRODUCT n addmsg /kinetics/MKP-1/MKP1-tyr-deph /kinetics/MKP-1 REAC eA B addmsg /kinetics/MKP-1/MKP1-thr-deph /kinetics/MKP-1 REAC eA B addmsg /kinetics/MKP-1/diff /kinetics/MKP-1 REAC A B addmsg /kinetics/MKP-1 /kinetics/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/MAPK/MAPK-tyr /kinetics/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/MKP-1 /kinetics/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/MAPK* /kinetics/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/MKP-1 /kinetics/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/MKP-1 /kinetics/MKP-1/diff PRODUCT n addmsg /kinetics/PPhosphatase2A/craf-deph /kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/PPhosphatase2A/MAPKK-deph /kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/PPhosphatase2A/MAPKK-deph-ser /kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/PPhosphatase2A/craf**-deph /kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/PPhosphatase2A/diff /kinetics/PPhosphatase2A REAC A B addmsg /kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/MAPK/craf-1* /kinetics/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/MAPK/MAPKK* /kinetics/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/MAPK/MAPKK-ser /kinetics/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/MAPK/craf-1** /kinetics/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/PPhosphatase2A /kinetics/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/CaM/CaM-TR2-bind-Ca /kinetics/CaM/CaM REAC A B addmsg /kinetics/CaM/CaM/diff /kinetics/CaM/CaM REAC A B addmsg /kinetics/CaM/CaM /kinetics/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM /kinetics/CaM/CaM/diff PRODUCT n addmsg /kinetics/CaM/CaM /kinetics/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/CaM/CaM-TR2-Ca2 /kinetics/CaM/CaM-TR2-bind-Ca PRODUCT n addmsg /kinetics/Ca /kinetics/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/Ca /kinetics/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/CaM/CaM-TR2-Ca2 /kinetics/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/Ca /kinetics/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/CaM/CaM-Ca3 /kinetics/CaM/CaM-TR2-Ca2-bind-Ca PRODUCT n addmsg /kinetics/CaM/CaM-Ca3 /kinetics/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/Ca /kinetics/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/CaM/CaM-Ca4 /kinetics/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/CaM/CaM-Ca3 REAC B A addmsg /kinetics/CaM/CaM-Ca3-bind-Ca /kinetics/CaM/CaM-Ca3 REAC A B addmsg /kinetics/CaM/CaM-Ca3/diff /kinetics/CaM/CaM-Ca3 REAC A B addmsg /kinetics/CaM/CaM-Ca3 /kinetics/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca3 /kinetics/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/CaM/CaM-TR2-bind-Ca /kinetics/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/CaM/CaM-TR2-Ca2/diff /kinetics/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/CaM/CaM-TR2-Ca2 /kinetics/CaM/CaM-TR2-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM-TR2-Ca2 /kinetics/CaM/CaM-TR2-Ca2/diff PRODUCT n addmsg /kinetics/Ras/CaM-bind-GEF /kinetics/CaM/CaM-Ca4 REAC A B addmsg /kinetics/CaM/CaM-Ca3-bind-Ca /kinetics/CaM/CaM-Ca4 REAC B A addmsg /kinetics/CaM/CaM-Ca4/diff /kinetics/CaM/CaM-Ca4 REAC A B addmsg /kinetics/CaM/CaM-Ca4 /kinetics/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca4 /kinetics/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/MAPK/craf-1 /kinetics/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/MAPK/Raf-GTP-Ras /kinetics/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/Ras/GTP-Ras /kinetics/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/Ca_diff /kinetics/Ca_input REAC A B addmsg /kinetics/Ca_input /kinetics/Ca_diff SUBSTRATE n addmsg /kinetics/Ca /kinetics/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-act-by-Ca /kinetics/chain/kinetics/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-act-by-DAG /kinetics/chain/kinetics/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-Ca/diff /kinetics/chain/kinetics/PKC/PKC-Ca REAC A B addmsg /kinetics/PKC/PKC-Ca/diff /kinetics/chain/kinetics/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-Ca /kinetics/chain/kinetics/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca /kinetics/chain/kinetics/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca /kinetics/chain/kinetics/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-cytosolic /kinetics/chain/kinetics/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics/Ca /kinetics/chain/kinetics/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca /kinetics/chain/kinetics/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-DAG /kinetics/chain/kinetics/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics/DAG /kinetics/chain/kinetics/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca /kinetics/chain/kinetics/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-memb* /kinetics/chain/kinetics/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-memb* /kinetics/chain/kinetics/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-DAG /kinetics/chain/kinetics/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca /kinetics/chain/kinetics/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-AA* /kinetics/chain/kinetics/PKC/PKC-act-by-Ca-AA PRODUCT n addmsg /kinetics/chain/kinetics/AA /kinetics/chain/kinetics/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-AA* /kinetics/chain/kinetics/PKC/PKC-act-by-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-AA /kinetics/chain/kinetics/PKC/PKC-act-by-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics/PKC/PKC-DAG-AA* REAC A B addmsg /kinetics/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-AA* /kinetics/chain/kinetics/PKC/PKC-DAG-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics/PKC/PKC-DAG-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics/PKC/PKC-Ca-AA* REAC A B addmsg /kinetics/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-AA* /kinetics/chain/kinetics/PKC/PKC-Ca-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics/PKC/PKC-Ca-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-memb* /kinetics/chain/kinetics/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-memb* /kinetics/chain/kinetics/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-basal-act /kinetics/chain/kinetics/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-basal*/diff /kinetics/chain/kinetics/PKC/PKC-basal* REAC A B addmsg /kinetics/PKC/PKC-basal*/diff /kinetics/chain/kinetics/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-basal* /kinetics/chain/kinetics/PKC/PKC-basal*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-basal* /kinetics/chain/kinetics/PKC/PKC-basal*/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-basal* /kinetics/chain/kinetics/PKC/PKC-basal-act PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-cytosolic /kinetics/chain/kinetics/PKC/PKC-basal-act SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-act-by-AA /kinetics/chain/kinetics/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-AA*/diff /kinetics/chain/kinetics/PKC/PKC-AA* REAC A B addmsg /kinetics/PKC/PKC-AA*/diff /kinetics/chain/kinetics/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-AA* /kinetics/chain/kinetics/PKC/PKC-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-AA* /kinetics/chain/kinetics/PKC/PKC-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-AA* /kinetics/chain/kinetics/PKC/PKC-act-by-AA PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-cytosolic /kinetics/chain/kinetics/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics/AA /kinetics/chain/kinetics/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-act-by-DAG /kinetics/chain/kinetics/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-DAG /kinetics/chain/kinetics/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-DAG /kinetics/chain/kinetics/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-cytosolic /kinetics/chain/kinetics/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics/DAG /kinetics/chain/kinetics/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-n-DAG /kinetics/chain/kinetics/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-DAG/diff /kinetics/chain/kinetics/PKC/PKC-DAG REAC A B addmsg /kinetics/PKC/PKC-DAG/diff /kinetics/chain/kinetics/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-DAG /kinetics/chain/kinetics/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG /kinetics/chain/kinetics/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-DAG /kinetics/chain/kinetics/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-AA /kinetics/chain/kinetics/PKC/PKC-n-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics/AA /kinetics/chain/kinetics/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-AA /kinetics/chain/kinetics/PKC/PKC-DAG-AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-AA /kinetics/chain/kinetics/PKC/PKC-DAG-AA/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-act-by-Ca /kinetics/chain/kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-basal-act /kinetics/chain/kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-act-by-AA /kinetics/chain/kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-n-DAG /kinetics/chain/kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics/PKC/PKC-cytosolic REAC A B addmsg /kinetics/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-cytosolic /kinetics/chain/kinetics/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic /kinetics/chain/kinetics/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics/AA REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-act-by-AA /kinetics/chain/kinetics/AA REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics/AA REAC A B addmsg /kinetics/chain/kinetics/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics/AA MM_PRD pA addmsg /kinetics/chain/kinetics/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics/AA MM_PRD pA addmsg /kinetics/chain/kinetics/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics/AA MM_PRD pA addmsg /kinetics/chain/kinetics/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics/AA MM_PRD pA addmsg /kinetics/chain/kinetics/PLA2/Degrade-AA /kinetics/chain/kinetics/AA REAC A B addmsg /kinetics/chain/kinetics/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics/AA MM_PRD pA addmsg /kinetics/chain/kinetics/AA/diff /kinetics/chain/kinetics/AA REAC A B addmsg /kinetics/AA/diff /kinetics/chain/kinetics/AA REAC B A addmsg /kinetics/chain/kinetics/AA /kinetics/chain/kinetics/AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/AA /kinetics/chain/kinetics/AA/diff PRODUCT n addmsg /kinetics/chain/kinetics/PLA2/PLA2-Ca-act /kinetics/chain/kinetics/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics/MAPK*/MAPK* /kinetics/chain/kinetics/PLA2/PLA2-cytosolic REAC sA B addmsg /kinetics/chain/kinetics/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics/PLA2/PLA2-cytosolic /kinetics/chain/kinetics/PLA2/PLA2-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics/PLA2/PLA2-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics/PLA2/PLA2-cytosolic /kinetics/chain/kinetics/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics/PLA2/PLA2-Ca* /kinetics/chain/kinetics/PLA2/PLA2-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics/Ca /kinetics/chain/kinetics/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics/PLA2/PLA2-Ca-act /kinetics/chain/kinetics/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics/PLA2/PLA2-Ca* REAC eA B addmsg /kinetics/chain/kinetics/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics/PLA2/PLA2-Ca* /kinetics/chain/kinetics/PLA2/PLA2-Ca*/kenz ENZYME n addmsg /kinetics/chain/kinetics/PLA2/APC /kinetics/chain/kinetics/PLA2/PLA2-Ca*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics/PLA2/PLA2-Ca* /kinetics/chain/kinetics/PLA2/PLA2-Ca*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca* /kinetics/chain/kinetics/PLA2/PLA2-Ca*/diff PRODUCT n addmsg /kinetics/chain/kinetics/PLA2/PLA2-cytosolic /kinetics/chain/kinetics/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics/PLA2/PIP2-PLA2* /kinetics/chain/kinetics/PLA2/PIP2-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics/temp-PIP2 /kinetics/chain/kinetics/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics/PLA2/PIP2-PLA2* REAC eA B addmsg /kinetics/chain/kinetics/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics/PLA2/PIP2-PLA2* REAC A B addmsg /kinetics/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics/PLA2/PIP2-PLA2* /kinetics/chain/kinetics/PLA2/PIP2-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics/PLA2/APC /kinetics/chain/kinetics/PLA2/PIP2-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics/PLA2/PIP2-PLA2* /kinetics/chain/kinetics/PLA2/PIP2-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics/PLA2/PIP2-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics/PLA2/PLA2-Ca* /kinetics/chain/kinetics/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics/PLA2/PIP2-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics/temp-PIP2 /kinetics/chain/kinetics/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics/PLA2/PIP2-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics/PLA2/PIP2-Ca-PLA2* REAC A B addmsg /kinetics/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics/PLA2/PIP2-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics/PLA2/APC /kinetics/chain/kinetics/PLA2/PIP2-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics/PLA2/PIP2-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics/PLA2/PIP2-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics/PLA2/PLA2-Ca* /kinetics/chain/kinetics/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics/PLA2/DAG-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics/DAG /kinetics/chain/kinetics/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics/PLA2/DAG-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics/PLA2/DAG-Ca-PLA2* REAC A B addmsg /kinetics/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics/PLA2/DAG-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics/PLA2/APC /kinetics/chain/kinetics/PLA2/DAG-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics/PLA2/DAG-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics/PLA2/DAG-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics/PLA2/Degrade-AA /kinetics/chain/kinetics/PLA2/APC REAC B A addmsg /kinetics/chain/kinetics/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics/AA /kinetics/chain/kinetics/PLA2/Degrade-AA SUBSTRATE n addmsg /kinetics/chain/kinetics/PLA2/APC /kinetics/chain/kinetics/PLA2/Degrade-AA PRODUCT n addmsg /kinetics/chain/kinetics/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics/PLA2/PLA2*-Ca REAC eA B addmsg /kinetics/chain/kinetics/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics/PLA2/PLA2*-Ca REAC A B addmsg /kinetics/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics/PLA2/APC /kinetics/chain/kinetics/PLA2/PLA2*-Ca/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics/PLA2/PLA2*-Ca /kinetics/chain/kinetics/PLA2/PLA2*-Ca/kenz ENZYME n addmsg /kinetics/chain/kinetics/PLA2/PLA2*-Ca /kinetics/chain/kinetics/PLA2/PLA2*-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca /kinetics/chain/kinetics/PLA2/PLA2*-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics/MAPK*/MAPK* /kinetics/chain/kinetics/PLA2/PLA2* MM_PRD pA addmsg /kinetics/chain/kinetics/PLA2/PLA2*/diff /kinetics/chain/kinetics/PLA2/PLA2* REAC A B addmsg /kinetics/PLA2/PLA2*/diff /kinetics/chain/kinetics/PLA2/PLA2* REAC B A addmsg /kinetics/chain/kinetics/PLA2/PLA2* /kinetics/chain/kinetics/PLA2/PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2* /kinetics/chain/kinetics/PLA2/PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics/PLA2/PLA2*-Ca /kinetics/chain/kinetics/PLA2/PLA2*-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics/PLA2/PLA2* /kinetics/chain/kinetics/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics/Ca /kinetics/chain/kinetics/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics/PLA2/PLA2-cytosolic /kinetics/chain/kinetics/PLA2/dephosphorylate-PLA2* PRODUCT n addmsg /kinetics/chain/kinetics/PLA2/PLA2* /kinetics/chain/kinetics/PLA2/dephosphorylate-PLA2* SUBSTRATE n addmsg /kinetics/chain/kinetics/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics/PKC-active/PKC-act-raf /kinetics/chain/kinetics/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics/PPhosphatase2A/craf-deph /kinetics/chain/kinetics/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics/Ras-act-unphosph-raf /kinetics/chain/kinetics/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics/Ras-act-craf /kinetics/chain/kinetics/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics/PKC-active/PKC-act-raf /kinetics/chain/kinetics/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK*/MAPK*-feedback /kinetics/chain/kinetics/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics/PPhosphatase2A/craf-deph /kinetics/chain/kinetics/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/MAPK/diff /kinetics/chain/kinetics/MAPK/MAPK REAC A B addmsg /kinetics/MAPK/MAPK/diff /kinetics/chain/kinetics/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics/MAPK/MAPK /kinetics/chain/kinetics/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK /kinetics/chain/kinetics/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics/MAPK*/MAPK*-feedback /kinetics/chain/kinetics/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics/MAPK/MAPK-tyr REAC A B addmsg /kinetics/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics/MAPK/MAPK-tyr /kinetics/chain/kinetics/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr /kinetics/chain/kinetics/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics/MAPK/MAPK /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/MAPKK* /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics/MAPK/MAPK-tyr /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/MAPKK* /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics/Ras-act-unphosph-raf /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics/MAPK/MAPKK /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics/MAPK/MAPKK-ser /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics/Ras-act-craf /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics/MAPK/MAPKK /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics/MAPK/MAPKK-ser /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics/MAPK/craf-1* /kinetics/chain/kinetics/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics/Ras/GTP-Ras /kinetics/chain/kinetics/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/inact-GEF /kinetics/chain/kinetics/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics/Ras/GEF* /kinetics/chain/kinetics/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/dephosph-GEF /kinetics/chain/kinetics/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics/Ras/CaM-bind-GEF /kinetics/chain/kinetics/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics/PKC-active/PKC-act-GEF /kinetics/chain/kinetics/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics/Ras/inact-GEF/diff /kinetics/chain/kinetics/Ras/inact-GEF REAC A B addmsg /kinetics/Ras/inact-GEF/diff /kinetics/chain/kinetics/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics/Ras/inact-GEF /kinetics/chain/kinetics/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics/Ras/GDP-Ras /kinetics/chain/kinetics/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/inact-GEF /kinetics/chain/kinetics/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF /kinetics/chain/kinetics/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics/Ras/dephosph-GEF /kinetics/chain/kinetics/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics/PKC-active/PKC-act-GEF /kinetics/chain/kinetics/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics/Ras/GEF*/diff /kinetics/chain/kinetics/Ras/GEF* REAC A B addmsg /kinetics/Ras/GEF*/diff /kinetics/chain/kinetics/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics/Ras/GEF* /kinetics/chain/kinetics/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics/Ras/GDP-Ras /kinetics/chain/kinetics/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/GEF* /kinetics/chain/kinetics/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/GEF* /kinetics/chain/kinetics/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics/Ras-act-craf /kinetics/chain/kinetics/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics/Ras-act-unphosph-raf /kinetics/chain/kinetics/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics/Ras/GTP-Ras /kinetics/chain/kinetics/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/GDP-Ras /kinetics/chain/kinetics/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics/Ras/GAP* /kinetics/chain/kinetics/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/GAP /kinetics/chain/kinetics/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics/Ras/dephosph-GAP /kinetics/chain/kinetics/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics/Ras/GAP*/diff /kinetics/chain/kinetics/Ras/GAP* REAC A B addmsg /kinetics/Ras/GAP*/diff /kinetics/chain/kinetics/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics/Ras/GAP* /kinetics/chain/kinetics/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/GAP* /kinetics/chain/kinetics/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics/Ras/dephosph-GAP /kinetics/chain/kinetics/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics/Ras/GAP/diff /kinetics/chain/kinetics/Ras/GAP REAC A B addmsg /kinetics/Ras/GAP/diff /kinetics/chain/kinetics/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics/Ras/GTP-Ras /kinetics/chain/kinetics/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/GAP /kinetics/chain/kinetics/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics/Ras/GAP /kinetics/chain/kinetics/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/GAP /kinetics/chain/kinetics/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics/Ras/inact-GEF /kinetics/chain/kinetics/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/CaM-GEF /kinetics/chain/kinetics/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca4 /kinetics/chain/kinetics/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/CaM-bind-GEF /kinetics/chain/kinetics/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics/Ras/CaM-GEF/diff /kinetics/chain/kinetics/Ras/CaM-GEF REAC A B addmsg /kinetics/Ras/CaM-GEF/diff /kinetics/chain/kinetics/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics/Ras/GDP-Ras /kinetics/chain/kinetics/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics/Ras/CaM-GEF /kinetics/chain/kinetics/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics/Ras/CaM-GEF /kinetics/chain/kinetics/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/CaM-GEF /kinetics/chain/kinetics/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics/PKC/PKC-act-by-Ca /kinetics/chain/kinetics/Ca REAC A B addmsg /kinetics/chain/kinetics/PLA2/PLA2-Ca-act /kinetics/chain/kinetics/Ca REAC A B addmsg /kinetics/chain/kinetics/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics/Ca REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics/Ca REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics/Ca REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics/Ca REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics/Ca REAC A B addmsg /kinetics/chain/kinetics/Ca_diff /kinetics/chain/kinetics/Ca REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-act-by-DAG /kinetics/chain/kinetics/DAG REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-n-DAG /kinetics/chain/kinetics/DAG REAC A B addmsg /kinetics/chain/kinetics/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics/DAG REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-AA* /kinetics/chain/kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-AA* /kinetics/chain/kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-memb* /kinetics/chain/kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-memb* /kinetics/chain/kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics/PKC/PKC-basal* /kinetics/chain/kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics/PKC/PKC-AA* /kinetics/chain/kinetics/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics/PKC-active/PKC-act-raf /kinetics/chain/kinetics/PKC-active REAC eA B addmsg /kinetics/chain/kinetics/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics/PKC-active REAC eA B addmsg /kinetics/chain/kinetics/PKC-active/PKC-act-GEF /kinetics/chain/kinetics/PKC-active REAC eA B addmsg /kinetics/chain/kinetics/PKC-active/phosph-AC2 /kinetics/chain/kinetics/PKC-active REAC eA B addmsg /kinetics/chain/kinetics/MAPK/craf-1 /kinetics/chain/kinetics/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC-active /kinetics/chain/kinetics/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics/Ras/GAP /kinetics/chain/kinetics/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC-active /kinetics/chain/kinetics/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics/Ras/inact-GEF /kinetics/chain/kinetics/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics/PKC-active /kinetics/chain/kinetics/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics/PKC-active /kinetics/chain/kinetics/PKC-active/phosph-AC2 ENZYME n addmsg /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK*/MAPK* /kinetics/chain/kinetics/MAPK* REAC eA B addmsg /kinetics/chain/kinetics/MAPK*/MAPK*-feedback /kinetics/chain/kinetics/MAPK* REAC eA B addmsg /kinetics/chain/kinetics/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics/MAPK* REAC sA B addmsg /kinetics/chain/kinetics/MAPK*/diff /kinetics/chain/kinetics/MAPK* REAC A B addmsg /kinetics/MAPK*/diff /kinetics/chain/kinetics/MAPK* REAC B A addmsg /kinetics/chain/kinetics/PLA2/PLA2-cytosolic /kinetics/chain/kinetics/MAPK*/MAPK* SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK* /kinetics/chain/kinetics/MAPK*/MAPK* ENZYME n addmsg /kinetics/chain/kinetics/MAPK/craf-1* /kinetics/chain/kinetics/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK* /kinetics/chain/kinetics/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics/MAPK* /kinetics/chain/kinetics/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK* /kinetics/chain/kinetics/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics/MKP-1/diff /kinetics/chain/kinetics/MKP-1 REAC A B addmsg /kinetics/MKP-1/diff /kinetics/chain/kinetics/MKP-1 REAC B A addmsg /kinetics/chain/kinetics/MAPK/MAPK-tyr /kinetics/chain/kinetics/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics/MKP-1 /kinetics/chain/kinetics/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics/MAPK* /kinetics/chain/kinetics/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics/MKP-1 /kinetics/chain/kinetics/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics/MKP-1 /kinetics/chain/kinetics/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MKP-1 /kinetics/chain/kinetics/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics/PPhosphatase2A/craf-deph /kinetics/chain/kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics/PPhosphatase2A/diff /kinetics/chain/kinetics/PPhosphatase2A REAC A B addmsg /kinetics/PPhosphatase2A/diff /kinetics/chain/kinetics/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics/MAPK/craf-1* /kinetics/chain/kinetics/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics/PPhosphatase2A /kinetics/chain/kinetics/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics/MAPK/MAPKK* /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics/PPhosphatase2A /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics/MAPK/MAPKK-ser /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics/PPhosphatase2A /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics/MAPK/craf-1** /kinetics/chain/kinetics/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics/PPhosphatase2A /kinetics/chain/kinetics/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics/PPhosphatase2A /kinetics/chain/kinetics/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A /kinetics/chain/kinetics/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM/diff /kinetics/chain/kinetics/CaM/CaM REAC A B addmsg /kinetics/CaM/CaM/diff /kinetics/chain/kinetics/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics/CaM/CaM /kinetics/chain/kinetics/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM /kinetics/chain/kinetics/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics/Ca /kinetics/chain/kinetics/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics/Ca /kinetics/chain/kinetics/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM /kinetics/chain/kinetics/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics/CaM/CaM-TR2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics/Ca /kinetics/chain/kinetics/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca3 /kinetics/chain/kinetics/CaM/CaM-TR2-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics/Ca /kinetics/chain/kinetics/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca3 /kinetics/chain/kinetics/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics/CaM/CaM-Ca4 /kinetics/chain/kinetics/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-Ca3/diff /kinetics/chain/kinetics/CaM/CaM-Ca3 REAC A B addmsg /kinetics/CaM/CaM-Ca3/diff /kinetics/chain/kinetics/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics/CaM/CaM-Ca3 /kinetics/chain/kinetics/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca3 /kinetics/chain/kinetics/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics/CaM/CaM-TR2-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics/CaM/CaM-TR2-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics/Ras/CaM-bind-GEF /kinetics/chain/kinetics/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics/CaM/CaM-Ca4/diff /kinetics/chain/kinetics/CaM/CaM-Ca4 REAC A B addmsg /kinetics/CaM/CaM-Ca4/diff /kinetics/chain/kinetics/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics/CaM/CaM-Ca4 /kinetics/chain/kinetics/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 /kinetics/chain/kinetics/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics/MAPK/craf-1 /kinetics/chain/kinetics/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics/Ras/GTP-Ras /kinetics/chain/kinetics/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics/Ca_diff /kinetics/chain/kinetics/Ca_input REAC A B addmsg /kinetics/chain/kinetics/Ca /kinetics/chain/kinetics/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics/Ca_input /kinetics/chain/kinetics/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[1]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[1]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[1]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[1]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-Ca/diff /kinetics/chain/kinetics[1]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[1]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca /kinetics/chain/kinetics[1]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca /kinetics/chain/kinetics[1]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ca /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca /kinetics/chain/kinetics[1]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[1]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[1]/DAG /kinetics/chain/kinetics[1]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca /kinetics/chain/kinetics[1]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[1]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[1]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[1]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca-AA PRODUCT n addmsg /kinetics/chain/kinetics[1]/AA /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[1]/PKC/PKC-act-by-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[1]/PKC/PKC-act-by-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[1]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[1]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[1]/PKC/PKC-DAG-AA* REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[1]/PKC/PKC-DAG-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[1]/PKC/PKC-DAG-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[1]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[1]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[1]/PKC/PKC-Ca-AA* REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[1]/PKC/PKC-Ca-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[1]/PKC/PKC-Ca-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-basal-act /kinetics/chain/kinetics[1]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-basal*/diff /kinetics/chain/kinetics[1]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[1]/PKC/PKC-basal* REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-basal* /kinetics/chain/kinetics[1]/PKC/PKC-basal*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-basal* /kinetics/chain/kinetics[1]/PKC/PKC-basal*/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-basal* /kinetics/chain/kinetics[1]/PKC/PKC-basal-act PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic /kinetics/chain/kinetics[1]/PKC/PKC-basal-act SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[1]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-AA*/diff /kinetics/chain/kinetics[1]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[1]/PKC/PKC-AA* REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-AA* /kinetics/chain/kinetics[1]/PKC/PKC-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-AA* /kinetics/chain/kinetics[1]/PKC/PKC-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-AA* /kinetics/chain/kinetics[1]/PKC/PKC-act-by-AA PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic /kinetics/chain/kinetics[1]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/AA /kinetics/chain/kinetics[1]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/DAG /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG /kinetics/chain/kinetics[1]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[1]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-DAG/diff /kinetics/chain/kinetics[1]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[1]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG /kinetics/chain/kinetics[1]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG /kinetics/chain/kinetics[1]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[1]/AA /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[1]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[1]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[1]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[1]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[1]/PKC/PKC-DAG-AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[1]/PKC/PKC-DAG-AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-basal-act /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[1]/AA REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[1]/AA REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[1]/AA REAC A B addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[1]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[1]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[1]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[1]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[1]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[1]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[1]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[1]/PLA2/Degrade-AA /kinetics/chain/kinetics[1]/AA REAC A B addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[1]/AA MM_PRD pA addmsg /kinetics/chain/kinetics/AA/diff /kinetics/chain/kinetics[1]/AA REAC B A addmsg /kinetics/chain/kinetics[1]/AA/diff /kinetics/chain/kinetics[1]/AA REAC A B addmsg /kinetics/chain/kinetics[1]/AA /kinetics/chain/kinetics[1]/AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/AA /kinetics/chain/kinetics[1]/AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[1]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[1]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[1]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[1]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[1]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[1]/MAPK*/MAPK* /kinetics/chain/kinetics[1]/PLA2/PLA2-cytosolic REAC sA B addmsg /kinetics/chain/kinetics/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[1]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[1]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[1]/PLA2/PLA2-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[1]/PLA2/PLA2-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ca /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca* REAC eA B addmsg /kinetics/chain/kinetics[1]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[1]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca*/kenz ENZYME n addmsg /kinetics/chain/kinetics[1]/PLA2/APC /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca*/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[1]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[1]/PLA2/PIP2-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[1]/temp-PIP2 /kinetics/chain/kinetics[1]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[1]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[1]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[1]/PLA2/PIP2-PLA2* REAC eA B addmsg /kinetics/chain/kinetics/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[1]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[1]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[1]/PLA2/PIP2-PLA2* REAC A B addmsg /kinetics/chain/kinetics[1]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[1]/PLA2/PIP2-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[1]/PLA2/APC /kinetics/chain/kinetics[1]/PLA2/PIP2-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[1]/PLA2/PIP2-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[1]/PLA2/PIP2-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[1]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[1]/PLA2/PIP2-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[1]/temp-PIP2 /kinetics/chain/kinetics[1]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[1]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[1]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[1]/PLA2/PIP2-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[1]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[1]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[1]/PLA2/PIP2-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[1]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[1]/PLA2/PIP2-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[1]/PLA2/APC /kinetics/chain/kinetics[1]/PLA2/PIP2-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[1]/PLA2/PIP2-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[1]/PLA2/PIP2-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[1]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[1]/PLA2/DAG-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[1]/DAG /kinetics/chain/kinetics[1]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[1]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[1]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[1]/PLA2/DAG-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[1]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[1]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[1]/PLA2/DAG-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[1]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[1]/PLA2/DAG-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[1]/PLA2/APC /kinetics/chain/kinetics[1]/PLA2/DAG-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[1]/PLA2/DAG-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[1]/PLA2/DAG-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[1]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[1]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[1]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[1]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[1]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[1]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[1]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[1]/PLA2/Degrade-AA /kinetics/chain/kinetics[1]/PLA2/APC REAC B A addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[1]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[1]/AA /kinetics/chain/kinetics[1]/PLA2/Degrade-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PLA2/APC /kinetics/chain/kinetics[1]/PLA2/Degrade-AA PRODUCT n addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca REAC eA B addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca REAC A B addmsg /kinetics/chain/kinetics[1]/PLA2/APC /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca/kenz ENZYME n addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[1]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[1]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[1]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[1]/MAPK*/MAPK* /kinetics/chain/kinetics[1]/PLA2/PLA2* MM_PRD pA addmsg /kinetics/chain/kinetics/PLA2/PLA2*/diff /kinetics/chain/kinetics[1]/PLA2/PLA2* REAC B A addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2*/diff /kinetics/chain/kinetics[1]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2* /kinetics/chain/kinetics[1]/PLA2/PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2* /kinetics/chain/kinetics[1]/PLA2/PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2* /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ca /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[1]/PLA2/dephosphorylate-PLA2* PRODUCT n addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2* /kinetics/chain/kinetics[1]/PLA2/dephosphorylate-PLA2* SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[1]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[1]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[1]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[1]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[1]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[1]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[1]/Ras-act-unphosph-raf /kinetics/chain/kinetics[1]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[1]/Ras-act-craf /kinetics/chain/kinetics[1]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[1]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[1]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[1]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[1]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[1]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[1]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[1]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[1]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[1]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[1]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[1]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/MAPK/diff /kinetics/chain/kinetics[1]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK/diff /kinetics/chain/kinetics[1]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK /kinetics/chain/kinetics[1]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK /kinetics/chain/kinetics[1]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[1]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[1]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[1]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[1]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[1]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[1]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[1]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[1]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[1]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK* /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK* /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[1]/Ras-act-unphosph-raf /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[1]/Ras-act-craf /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1* /kinetics/chain/kinetics[1]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[1]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ras/GTP-Ras /kinetics/chain/kinetics[1]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF /kinetics/chain/kinetics[1]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ras/GEF* /kinetics/chain/kinetics[1]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/dephosph-GEF /kinetics/chain/kinetics[1]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[1]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[1]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[1]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[1]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[1]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics/Ras/inact-GEF/diff /kinetics/chain/kinetics[1]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF/diff /kinetics/chain/kinetics[1]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF /kinetics/chain/kinetics[1]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[1]/Ras/GDP-Ras /kinetics/chain/kinetics[1]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF /kinetics/chain/kinetics[1]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF /kinetics/chain/kinetics[1]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ras/dephosph-GEF /kinetics/chain/kinetics[1]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[1]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[1]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[1]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics/Ras/GEF*/diff /kinetics/chain/kinetics[1]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[1]/Ras/GEF*/diff /kinetics/chain/kinetics[1]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/GEF* /kinetics/chain/kinetics[1]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[1]/Ras/GDP-Ras /kinetics/chain/kinetics[1]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/GEF* /kinetics/chain/kinetics[1]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/GEF* /kinetics/chain/kinetics[1]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ras-act-craf /kinetics/chain/kinetics[1]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[1]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[1]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[1]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[1]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[1]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[1]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[1]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[1]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[1]/Ras-act-unphosph-raf /kinetics/chain/kinetics[1]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[1]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[1]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[1]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[1]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[1]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[1]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[1]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[1]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[1]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[1]/Ras/GTP-Ras /kinetics/chain/kinetics[1]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/GDP-Ras /kinetics/chain/kinetics[1]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ras/GAP* /kinetics/chain/kinetics[1]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/GAP /kinetics/chain/kinetics[1]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ras/dephosph-GAP /kinetics/chain/kinetics[1]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[1]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[1]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics/Ras/GAP*/diff /kinetics/chain/kinetics[1]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[1]/Ras/GAP*/diff /kinetics/chain/kinetics[1]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/GAP* /kinetics/chain/kinetics[1]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/GAP* /kinetics/chain/kinetics[1]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ras/dephosph-GAP /kinetics/chain/kinetics[1]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[1]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[1]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[1]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[1]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics/Ras/GAP/diff /kinetics/chain/kinetics[1]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[1]/Ras/GAP/diff /kinetics/chain/kinetics[1]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/GTP-Ras /kinetics/chain/kinetics[1]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/GAP /kinetics/chain/kinetics[1]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[1]/Ras/GAP /kinetics/chain/kinetics[1]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/GAP /kinetics/chain/kinetics[1]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF /kinetics/chain/kinetics[1]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/CaM-GEF /kinetics/chain/kinetics[1]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 /kinetics/chain/kinetics[1]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[1]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[1]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[1]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics/Ras/CaM-GEF/diff /kinetics/chain/kinetics[1]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[1]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[1]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[1]/Ras/GDP-Ras /kinetics/chain/kinetics[1]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ras/CaM-GEF /kinetics/chain/kinetics[1]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[1]/Ras/CaM-GEF /kinetics/chain/kinetics[1]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/CaM-GEF /kinetics/chain/kinetics[1]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[1]/Ca REAC A B addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[1]/Ca REAC A B addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[1]/Ca REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[1]/Ca REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[1]/Ca REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[1]/Ca REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[1]/Ca REAC A B addmsg /kinetics/chain/kinetics[1]/Ca_diff /kinetics/chain/kinetics[1]/Ca REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[1]/DAG REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG /kinetics/chain/kinetics[1]/DAG REAC A B addmsg /kinetics/chain/kinetics[1]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[1]/DAG REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[1]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[1]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[1]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[1]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[1]/PKC/PKC-basal* /kinetics/chain/kinetics[1]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[1]/PKC/PKC-AA* /kinetics/chain/kinetics[1]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[1]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[1]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[1]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[1]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[1]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[1]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[1]/PKC-active/phosph-AC2 /kinetics/chain/kinetics[1]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1 /kinetics/chain/kinetics[1]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC-active /kinetics/chain/kinetics[1]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[1]/Ras/GAP /kinetics/chain/kinetics[1]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC-active /kinetics/chain/kinetics[1]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF /kinetics/chain/kinetics[1]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PKC-active /kinetics/chain/kinetics[1]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[1]/PKC-active /kinetics/chain/kinetics[1]/PKC-active/phosph-AC2 ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[1]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MAPK*/MAPK* /kinetics/chain/kinetics[1]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[1]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[1]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[1]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[1]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics/MAPK*/diff /kinetics/chain/kinetics[1]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[1]/MAPK*/diff /kinetics/chain/kinetics[1]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[1]/MAPK*/MAPK* SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK* /kinetics/chain/kinetics[1]/MAPK*/MAPK* ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1* /kinetics/chain/kinetics[1]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK* /kinetics/chain/kinetics[1]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK* /kinetics/chain/kinetics[1]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK* /kinetics/chain/kinetics[1]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[1]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[1]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[1]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics/MKP-1/diff /kinetics/chain/kinetics[1]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[1]/MKP-1/diff /kinetics/chain/kinetics[1]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr /kinetics/chain/kinetics[1]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MKP-1 /kinetics/chain/kinetics[1]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK* /kinetics/chain/kinetics[1]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MKP-1 /kinetics/chain/kinetics[1]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[1]/MKP-1 /kinetics/chain/kinetics[1]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MKP-1 /kinetics/chain/kinetics[1]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[1]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[1]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[1]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[1]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics/PPhosphatase2A/diff /kinetics/chain/kinetics[1]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/diff /kinetics/chain/kinetics[1]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1* /kinetics/chain/kinetics[1]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A /kinetics/chain/kinetics[1]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK* /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1** /kinetics/chain/kinetics[1]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A /kinetics/chain/kinetics[1]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A /kinetics/chain/kinetics[1]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A /kinetics/chain/kinetics[1]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[1]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM/diff /kinetics/chain/kinetics[1]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[1]/CaM/CaM/diff /kinetics/chain/kinetics[1]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM /kinetics/chain/kinetics[1]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM /kinetics/chain/kinetics[1]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ca /kinetics/chain/kinetics[1]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ca /kinetics/chain/kinetics[1]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM /kinetics/chain/kinetics[1]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[1]/CaM/CaM-TR2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ca /kinetics/chain/kinetics[1]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca3 /kinetics/chain/kinetics[1]/CaM/CaM-TR2-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[1]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca3 /kinetics/chain/kinetics[1]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 /kinetics/chain/kinetics[1]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[1]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[1]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca3 /kinetics/chain/kinetics[1]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca3 /kinetics/chain/kinetics[1]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[1]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[1]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[1]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[1]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[1]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[1]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[1]/CaM/CaM-TR2-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[1]/CaM/CaM-TR2-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca4 /kinetics/chain/kinetics[1]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca4 /kinetics/chain/kinetics[1]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/MAPK/craf-1 /kinetics/chain/kinetics[1]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[1]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ras/GTP-Ras /kinetics/chain/kinetics[1]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[1]/Ca_diff /kinetics/chain/kinetics[1]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[1]/Ca /kinetics/chain/kinetics[1]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[1]/Ca_input /kinetics/chain/kinetics[1]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[2]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[2]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[2]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[2]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[2]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[2]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca /kinetics/chain/kinetics[2]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca /kinetics/chain/kinetics[2]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ca /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca /kinetics/chain/kinetics[2]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[2]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[2]/DAG /kinetics/chain/kinetics[2]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca /kinetics/chain/kinetics[2]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[2]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[2]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[2]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca-AA PRODUCT n addmsg /kinetics/chain/kinetics[2]/AA /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[2]/PKC/PKC-act-by-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[2]/PKC/PKC-act-by-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[2]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[2]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[2]/PKC/PKC-DAG-AA* REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[2]/PKC/PKC-DAG-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[2]/PKC/PKC-DAG-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[2]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[2]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[2]/PKC/PKC-Ca-AA* REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[2]/PKC/PKC-Ca-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[2]/PKC/PKC-Ca-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-basal-act /kinetics/chain/kinetics[2]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[2]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[2]/PKC/PKC-basal* REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-basal* /kinetics/chain/kinetics[2]/PKC/PKC-basal*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-basal* /kinetics/chain/kinetics[2]/PKC/PKC-basal*/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-basal* /kinetics/chain/kinetics[2]/PKC/PKC-basal-act PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic /kinetics/chain/kinetics[2]/PKC/PKC-basal-act SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[2]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[2]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[2]/PKC/PKC-AA* REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-AA* /kinetics/chain/kinetics[2]/PKC/PKC-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-AA* /kinetics/chain/kinetics[2]/PKC/PKC-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-AA* /kinetics/chain/kinetics[2]/PKC/PKC-act-by-AA PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic /kinetics/chain/kinetics[2]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/AA /kinetics/chain/kinetics[2]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/DAG /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG /kinetics/chain/kinetics[2]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[2]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[2]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[2]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG /kinetics/chain/kinetics[2]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG /kinetics/chain/kinetics[2]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[2]/AA /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[2]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[2]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[1]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[2]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[2]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[2]/PKC/PKC-DAG-AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[2]/PKC/PKC-DAG-AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-basal-act /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[2]/AA REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[2]/AA REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[2]/AA REAC A B addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[2]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[2]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[2]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[2]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[2]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[2]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[2]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[2]/PLA2/Degrade-AA /kinetics/chain/kinetics[2]/AA REAC A B addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[2]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[1]/AA/diff /kinetics/chain/kinetics[2]/AA REAC B A addmsg /kinetics/chain/kinetics[2]/AA/diff /kinetics/chain/kinetics[2]/AA REAC A B addmsg /kinetics/chain/kinetics[2]/AA /kinetics/chain/kinetics[2]/AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/AA /kinetics/chain/kinetics[2]/AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[2]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[2]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[2]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[2]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[2]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[2]/MAPK*/MAPK* /kinetics/chain/kinetics[2]/PLA2/PLA2-cytosolic REAC sA B addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[2]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[2]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[2]/PLA2/PLA2-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[2]/PLA2/PLA2-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ca /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca* REAC eA B addmsg /kinetics/chain/kinetics[2]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[2]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca*/kenz ENZYME n addmsg /kinetics/chain/kinetics[2]/PLA2/APC /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca*/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[2]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[2]/PLA2/PIP2-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[2]/temp-PIP2 /kinetics/chain/kinetics[2]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[2]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[2]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[2]/PLA2/PIP2-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[1]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[2]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[2]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[2]/PLA2/PIP2-PLA2* REAC A B addmsg /kinetics/chain/kinetics[2]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[2]/PLA2/PIP2-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[2]/PLA2/APC /kinetics/chain/kinetics[2]/PLA2/PIP2-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[2]/PLA2/PIP2-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[2]/PLA2/PIP2-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[2]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[2]/PLA2/PIP2-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[2]/temp-PIP2 /kinetics/chain/kinetics[2]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[2]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[2]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[2]/PLA2/PIP2-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[1]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[2]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[2]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[2]/PLA2/PIP2-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[2]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[2]/PLA2/PIP2-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[2]/PLA2/APC /kinetics/chain/kinetics[2]/PLA2/PIP2-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[2]/PLA2/PIP2-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[2]/PLA2/PIP2-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[2]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[2]/PLA2/DAG-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[2]/DAG /kinetics/chain/kinetics[2]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[2]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[2]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[2]/PLA2/DAG-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[1]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[2]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[2]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[2]/PLA2/DAG-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[2]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[2]/PLA2/DAG-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[2]/PLA2/APC /kinetics/chain/kinetics[2]/PLA2/DAG-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[2]/PLA2/DAG-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[2]/PLA2/DAG-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[2]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[2]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[2]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[2]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[2]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[2]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[2]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[2]/PLA2/Degrade-AA /kinetics/chain/kinetics[2]/PLA2/APC REAC B A addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[2]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[2]/AA /kinetics/chain/kinetics[2]/PLA2/Degrade-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PLA2/APC /kinetics/chain/kinetics[2]/PLA2/Degrade-AA PRODUCT n addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca REAC eA B addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca REAC A B addmsg /kinetics/chain/kinetics[2]/PLA2/APC /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca/kenz ENZYME n addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[2]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[2]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[2]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[2]/MAPK*/MAPK* /kinetics/chain/kinetics[2]/PLA2/PLA2* MM_PRD pA addmsg /kinetics/chain/kinetics[1]/PLA2/PLA2*/diff /kinetics/chain/kinetics[2]/PLA2/PLA2* REAC B A addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2*/diff /kinetics/chain/kinetics[2]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2* /kinetics/chain/kinetics[2]/PLA2/PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2* /kinetics/chain/kinetics[2]/PLA2/PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2* /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ca /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[2]/PLA2/dephosphorylate-PLA2* PRODUCT n addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2* /kinetics/chain/kinetics[2]/PLA2/dephosphorylate-PLA2* SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[2]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[2]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[2]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[2]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[2]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[2]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[2]/Ras-act-unphosph-raf /kinetics/chain/kinetics[2]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[2]/Ras-act-craf /kinetics/chain/kinetics[2]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[2]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[2]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[2]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[2]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[2]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[2]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[2]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[2]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[2]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[2]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[2]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK/diff /kinetics/chain/kinetics[2]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK/diff /kinetics/chain/kinetics[2]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK /kinetics/chain/kinetics[2]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK /kinetics/chain/kinetics[2]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[2]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[2]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[2]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[2]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[2]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[2]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[2]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[2]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[2]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK* /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK* /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[2]/Ras-act-unphosph-raf /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[2]/Ras-act-craf /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1* /kinetics/chain/kinetics[2]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[2]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ras/GTP-Ras /kinetics/chain/kinetics[2]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF /kinetics/chain/kinetics[2]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ras/GEF* /kinetics/chain/kinetics[2]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/dephosph-GEF /kinetics/chain/kinetics[2]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[2]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[2]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[2]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[2]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[2]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[1]/Ras/inact-GEF/diff /kinetics/chain/kinetics[2]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF/diff /kinetics/chain/kinetics[2]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF /kinetics/chain/kinetics[2]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[2]/Ras/GDP-Ras /kinetics/chain/kinetics[2]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF /kinetics/chain/kinetics[2]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF /kinetics/chain/kinetics[2]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ras/dephosph-GEF /kinetics/chain/kinetics[2]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[2]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[2]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[2]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[1]/Ras/GEF*/diff /kinetics/chain/kinetics[2]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[2]/Ras/GEF*/diff /kinetics/chain/kinetics[2]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/GEF* /kinetics/chain/kinetics[2]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[2]/Ras/GDP-Ras /kinetics/chain/kinetics[2]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/GEF* /kinetics/chain/kinetics[2]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/GEF* /kinetics/chain/kinetics[2]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ras-act-craf /kinetics/chain/kinetics[2]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[2]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[2]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[2]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[2]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[2]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[2]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[2]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[2]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[2]/Ras-act-unphosph-raf /kinetics/chain/kinetics[2]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[2]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[2]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[2]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[2]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[2]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[2]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[2]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[2]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[2]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[2]/Ras/GTP-Ras /kinetics/chain/kinetics[2]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/GDP-Ras /kinetics/chain/kinetics[2]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ras/GAP* /kinetics/chain/kinetics[2]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/GAP /kinetics/chain/kinetics[2]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ras/dephosph-GAP /kinetics/chain/kinetics[2]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[2]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[2]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[1]/Ras/GAP*/diff /kinetics/chain/kinetics[2]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[2]/Ras/GAP*/diff /kinetics/chain/kinetics[2]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/GAP* /kinetics/chain/kinetics[2]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/GAP* /kinetics/chain/kinetics[2]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ras/dephosph-GAP /kinetics/chain/kinetics[2]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[2]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[2]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[2]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[2]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[1]/Ras/GAP/diff /kinetics/chain/kinetics[2]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[2]/Ras/GAP/diff /kinetics/chain/kinetics[2]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/GTP-Ras /kinetics/chain/kinetics[2]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/GAP /kinetics/chain/kinetics[2]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[2]/Ras/GAP /kinetics/chain/kinetics[2]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/GAP /kinetics/chain/kinetics[2]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF /kinetics/chain/kinetics[2]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/CaM-GEF /kinetics/chain/kinetics[2]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca4 /kinetics/chain/kinetics[2]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[2]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[2]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[2]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[1]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[2]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[2]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[2]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[2]/Ras/GDP-Ras /kinetics/chain/kinetics[2]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ras/CaM-GEF /kinetics/chain/kinetics[2]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[2]/Ras/CaM-GEF /kinetics/chain/kinetics[2]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/CaM-GEF /kinetics/chain/kinetics[2]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[2]/Ca REAC A B addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[2]/Ca REAC A B addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[2]/Ca REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[2]/Ca REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[2]/Ca REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[2]/Ca REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[2]/Ca REAC A B addmsg /kinetics/chain/kinetics[2]/Ca_diff /kinetics/chain/kinetics[2]/Ca REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[2]/DAG REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG /kinetics/chain/kinetics[2]/DAG REAC A B addmsg /kinetics/chain/kinetics[2]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[2]/DAG REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[2]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[2]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[2]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[2]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[2]/PKC/PKC-basal* /kinetics/chain/kinetics[2]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[2]/PKC/PKC-AA* /kinetics/chain/kinetics[2]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[2]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[2]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[2]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[2]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[2]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[2]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[2]/PKC-active/phosph-AC2 /kinetics/chain/kinetics[2]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1 /kinetics/chain/kinetics[2]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC-active /kinetics/chain/kinetics[2]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[2]/Ras/GAP /kinetics/chain/kinetics[2]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC-active /kinetics/chain/kinetics[2]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF /kinetics/chain/kinetics[2]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PKC-active /kinetics/chain/kinetics[2]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[2]/PKC-active /kinetics/chain/kinetics[2]/PKC-active/phosph-AC2 ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[2]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MAPK*/MAPK* /kinetics/chain/kinetics[2]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[2]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[2]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[2]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[2]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[1]/MAPK*/diff /kinetics/chain/kinetics[2]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[2]/MAPK*/diff /kinetics/chain/kinetics[2]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[2]/MAPK*/MAPK* SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK* /kinetics/chain/kinetics[2]/MAPK*/MAPK* ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1* /kinetics/chain/kinetics[2]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK* /kinetics/chain/kinetics[2]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK* /kinetics/chain/kinetics[2]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK* /kinetics/chain/kinetics[2]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[2]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[2]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[2]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[1]/MKP-1/diff /kinetics/chain/kinetics[2]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[2]/MKP-1/diff /kinetics/chain/kinetics[2]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr /kinetics/chain/kinetics[2]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MKP-1 /kinetics/chain/kinetics[2]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK* /kinetics/chain/kinetics[2]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MKP-1 /kinetics/chain/kinetics[2]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[2]/MKP-1 /kinetics/chain/kinetics[2]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MKP-1 /kinetics/chain/kinetics[2]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[2]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[2]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[2]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[2]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[1]/PPhosphatase2A/diff /kinetics/chain/kinetics[2]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/diff /kinetics/chain/kinetics[2]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1* /kinetics/chain/kinetics[2]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A /kinetics/chain/kinetics[2]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK* /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1** /kinetics/chain/kinetics[2]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A /kinetics/chain/kinetics[2]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A /kinetics/chain/kinetics[2]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A /kinetics/chain/kinetics[2]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[2]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM/diff /kinetics/chain/kinetics[2]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[2]/CaM/CaM/diff /kinetics/chain/kinetics[2]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM /kinetics/chain/kinetics[2]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM /kinetics/chain/kinetics[2]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ca /kinetics/chain/kinetics[2]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ca /kinetics/chain/kinetics[2]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM /kinetics/chain/kinetics[2]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[2]/CaM/CaM-TR2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ca /kinetics/chain/kinetics[2]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca3 /kinetics/chain/kinetics[2]/CaM/CaM-TR2-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[2]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca3 /kinetics/chain/kinetics[2]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca4 /kinetics/chain/kinetics[2]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[2]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[2]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca3 /kinetics/chain/kinetics[2]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca3 /kinetics/chain/kinetics[2]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[2]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[2]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[2]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[1]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[2]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[2]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[2]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[2]/CaM/CaM-TR2-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[2]/CaM/CaM-TR2-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[2]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[2]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[1]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[2]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[2]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca4 /kinetics/chain/kinetics[2]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca4 /kinetics/chain/kinetics[2]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/MAPK/craf-1 /kinetics/chain/kinetics[2]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[2]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ras/GTP-Ras /kinetics/chain/kinetics[2]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[2]/Ca_diff /kinetics/chain/kinetics[2]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[2]/Ca /kinetics/chain/kinetics[2]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[2]/Ca_input /kinetics/chain/kinetics[2]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[3]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[3]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[3]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[3]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[3]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[3]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca /kinetics/chain/kinetics[3]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca /kinetics/chain/kinetics[3]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ca /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca /kinetics/chain/kinetics[3]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[3]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[3]/DAG /kinetics/chain/kinetics[3]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca /kinetics/chain/kinetics[3]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[3]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[3]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[3]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca-AA PRODUCT n addmsg /kinetics/chain/kinetics[3]/AA /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[3]/PKC/PKC-act-by-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[3]/PKC/PKC-act-by-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[3]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[3]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[3]/PKC/PKC-DAG-AA* REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[3]/PKC/PKC-DAG-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[3]/PKC/PKC-DAG-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[3]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[3]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[3]/PKC/PKC-Ca-AA* REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[3]/PKC/PKC-Ca-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[3]/PKC/PKC-Ca-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-basal-act /kinetics/chain/kinetics[3]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[3]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[3]/PKC/PKC-basal* REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-basal* /kinetics/chain/kinetics[3]/PKC/PKC-basal*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-basal* /kinetics/chain/kinetics[3]/PKC/PKC-basal*/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-basal* /kinetics/chain/kinetics[3]/PKC/PKC-basal-act PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic /kinetics/chain/kinetics[3]/PKC/PKC-basal-act SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[3]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[3]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[3]/PKC/PKC-AA* REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-AA* /kinetics/chain/kinetics[3]/PKC/PKC-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-AA* /kinetics/chain/kinetics[3]/PKC/PKC-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-AA* /kinetics/chain/kinetics[3]/PKC/PKC-act-by-AA PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic /kinetics/chain/kinetics[3]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/AA /kinetics/chain/kinetics[3]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/DAG /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG /kinetics/chain/kinetics[3]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[3]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[3]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[3]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG /kinetics/chain/kinetics[3]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG /kinetics/chain/kinetics[3]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[3]/AA /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[3]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[3]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[2]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[3]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[3]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[3]/PKC/PKC-DAG-AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[3]/PKC/PKC-DAG-AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-basal-act /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[3]/AA REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[3]/AA REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[3]/AA REAC A B addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[3]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[3]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[3]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[3]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[3]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[3]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[3]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[3]/PLA2/Degrade-AA /kinetics/chain/kinetics[3]/AA REAC A B addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[3]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[2]/AA/diff /kinetics/chain/kinetics[3]/AA REAC B A addmsg /kinetics/chain/kinetics[3]/AA/diff /kinetics/chain/kinetics[3]/AA REAC A B addmsg /kinetics/chain/kinetics[3]/AA /kinetics/chain/kinetics[3]/AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/AA /kinetics/chain/kinetics[3]/AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[3]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[3]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[3]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[3]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[3]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[3]/MAPK*/MAPK* /kinetics/chain/kinetics[3]/PLA2/PLA2-cytosolic REAC sA B addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[3]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[3]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[3]/PLA2/PLA2-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[3]/PLA2/PLA2-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ca /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca* REAC eA B addmsg /kinetics/chain/kinetics[3]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[3]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca*/kenz ENZYME n addmsg /kinetics/chain/kinetics[3]/PLA2/APC /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca*/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[3]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[3]/PLA2/PIP2-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[3]/temp-PIP2 /kinetics/chain/kinetics[3]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[3]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[3]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[3]/PLA2/PIP2-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[2]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[3]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[3]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[3]/PLA2/PIP2-PLA2* REAC A B addmsg /kinetics/chain/kinetics[3]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[3]/PLA2/PIP2-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[3]/PLA2/APC /kinetics/chain/kinetics[3]/PLA2/PIP2-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[3]/PLA2/PIP2-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[3]/PLA2/PIP2-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[3]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[3]/PLA2/PIP2-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[3]/temp-PIP2 /kinetics/chain/kinetics[3]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[3]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[3]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[3]/PLA2/PIP2-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[2]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[3]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[3]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[3]/PLA2/PIP2-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[3]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[3]/PLA2/PIP2-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[3]/PLA2/APC /kinetics/chain/kinetics[3]/PLA2/PIP2-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[3]/PLA2/PIP2-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[3]/PLA2/PIP2-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[3]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[3]/PLA2/DAG-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[3]/DAG /kinetics/chain/kinetics[3]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[3]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[3]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[3]/PLA2/DAG-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[2]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[3]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[3]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[3]/PLA2/DAG-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[3]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[3]/PLA2/DAG-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[3]/PLA2/APC /kinetics/chain/kinetics[3]/PLA2/DAG-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[3]/PLA2/DAG-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[3]/PLA2/DAG-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[3]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[3]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[3]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[3]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[3]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[3]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[3]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[3]/PLA2/Degrade-AA /kinetics/chain/kinetics[3]/PLA2/APC REAC B A addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[3]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[3]/AA /kinetics/chain/kinetics[3]/PLA2/Degrade-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PLA2/APC /kinetics/chain/kinetics[3]/PLA2/Degrade-AA PRODUCT n addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca REAC eA B addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca REAC A B addmsg /kinetics/chain/kinetics[3]/PLA2/APC /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca/kenz ENZYME n addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[3]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[3]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[3]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[3]/MAPK*/MAPK* /kinetics/chain/kinetics[3]/PLA2/PLA2* MM_PRD pA addmsg /kinetics/chain/kinetics[2]/PLA2/PLA2*/diff /kinetics/chain/kinetics[3]/PLA2/PLA2* REAC B A addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2*/diff /kinetics/chain/kinetics[3]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2* /kinetics/chain/kinetics[3]/PLA2/PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2* /kinetics/chain/kinetics[3]/PLA2/PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2* /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ca /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[3]/PLA2/dephosphorylate-PLA2* PRODUCT n addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2* /kinetics/chain/kinetics[3]/PLA2/dephosphorylate-PLA2* SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[3]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[3]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[3]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[3]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[3]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[3]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[3]/Ras-act-unphosph-raf /kinetics/chain/kinetics[3]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[3]/Ras-act-craf /kinetics/chain/kinetics[3]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[3]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[3]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[3]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[3]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[3]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[3]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[3]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[3]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[3]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[3]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[3]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK/diff /kinetics/chain/kinetics[3]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK/diff /kinetics/chain/kinetics[3]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK /kinetics/chain/kinetics[3]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK /kinetics/chain/kinetics[3]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[3]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[3]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[3]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[3]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[3]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[3]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[3]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[3]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[3]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK* /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK* /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[3]/Ras-act-unphosph-raf /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[3]/Ras-act-craf /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1* /kinetics/chain/kinetics[3]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[3]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ras/GTP-Ras /kinetics/chain/kinetics[3]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF /kinetics/chain/kinetics[3]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ras/GEF* /kinetics/chain/kinetics[3]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/dephosph-GEF /kinetics/chain/kinetics[3]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[3]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[3]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[3]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[3]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[3]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[2]/Ras/inact-GEF/diff /kinetics/chain/kinetics[3]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF/diff /kinetics/chain/kinetics[3]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF /kinetics/chain/kinetics[3]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[3]/Ras/GDP-Ras /kinetics/chain/kinetics[3]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF /kinetics/chain/kinetics[3]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF /kinetics/chain/kinetics[3]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ras/dephosph-GEF /kinetics/chain/kinetics[3]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[3]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[3]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[3]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[2]/Ras/GEF*/diff /kinetics/chain/kinetics[3]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[3]/Ras/GEF*/diff /kinetics/chain/kinetics[3]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/GEF* /kinetics/chain/kinetics[3]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[3]/Ras/GDP-Ras /kinetics/chain/kinetics[3]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/GEF* /kinetics/chain/kinetics[3]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/GEF* /kinetics/chain/kinetics[3]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ras-act-craf /kinetics/chain/kinetics[3]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[3]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[3]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[3]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[3]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[3]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[3]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[3]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[3]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[3]/Ras-act-unphosph-raf /kinetics/chain/kinetics[3]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[3]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[3]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[3]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[3]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[3]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[3]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[3]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[3]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[3]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[3]/Ras/GTP-Ras /kinetics/chain/kinetics[3]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/GDP-Ras /kinetics/chain/kinetics[3]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ras/GAP* /kinetics/chain/kinetics[3]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/GAP /kinetics/chain/kinetics[3]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ras/dephosph-GAP /kinetics/chain/kinetics[3]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[3]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[3]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[2]/Ras/GAP*/diff /kinetics/chain/kinetics[3]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[3]/Ras/GAP*/diff /kinetics/chain/kinetics[3]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/GAP* /kinetics/chain/kinetics[3]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/GAP* /kinetics/chain/kinetics[3]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ras/dephosph-GAP /kinetics/chain/kinetics[3]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[3]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[3]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[3]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[3]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[2]/Ras/GAP/diff /kinetics/chain/kinetics[3]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[3]/Ras/GAP/diff /kinetics/chain/kinetics[3]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/GTP-Ras /kinetics/chain/kinetics[3]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/GAP /kinetics/chain/kinetics[3]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[3]/Ras/GAP /kinetics/chain/kinetics[3]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/GAP /kinetics/chain/kinetics[3]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF /kinetics/chain/kinetics[3]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/CaM-GEF /kinetics/chain/kinetics[3]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca4 /kinetics/chain/kinetics[3]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[3]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[3]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[3]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[2]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[3]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[3]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[3]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[3]/Ras/GDP-Ras /kinetics/chain/kinetics[3]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ras/CaM-GEF /kinetics/chain/kinetics[3]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[3]/Ras/CaM-GEF /kinetics/chain/kinetics[3]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/CaM-GEF /kinetics/chain/kinetics[3]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[3]/Ca REAC A B addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[3]/Ca REAC A B addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[3]/Ca REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[3]/Ca REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[3]/Ca REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[3]/Ca REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[3]/Ca REAC A B addmsg /kinetics/chain/kinetics[3]/Ca_diff /kinetics/chain/kinetics[3]/Ca REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[3]/DAG REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG /kinetics/chain/kinetics[3]/DAG REAC A B addmsg /kinetics/chain/kinetics[3]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[3]/DAG REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[3]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[3]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[3]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[3]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[3]/PKC/PKC-basal* /kinetics/chain/kinetics[3]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[3]/PKC/PKC-AA* /kinetics/chain/kinetics[3]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[3]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[3]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[3]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[3]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[3]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[3]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[3]/PKC-active/phosph-AC2 /kinetics/chain/kinetics[3]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1 /kinetics/chain/kinetics[3]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC-active /kinetics/chain/kinetics[3]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[3]/Ras/GAP /kinetics/chain/kinetics[3]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC-active /kinetics/chain/kinetics[3]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF /kinetics/chain/kinetics[3]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PKC-active /kinetics/chain/kinetics[3]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[3]/PKC-active /kinetics/chain/kinetics[3]/PKC-active/phosph-AC2 ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[3]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MAPK*/MAPK* /kinetics/chain/kinetics[3]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[3]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[3]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[3]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[3]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[2]/MAPK*/diff /kinetics/chain/kinetics[3]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[3]/MAPK*/diff /kinetics/chain/kinetics[3]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[3]/MAPK*/MAPK* SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK* /kinetics/chain/kinetics[3]/MAPK*/MAPK* ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1* /kinetics/chain/kinetics[3]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK* /kinetics/chain/kinetics[3]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK* /kinetics/chain/kinetics[3]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK* /kinetics/chain/kinetics[3]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[3]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[3]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[3]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[2]/MKP-1/diff /kinetics/chain/kinetics[3]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[3]/MKP-1/diff /kinetics/chain/kinetics[3]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr /kinetics/chain/kinetics[3]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MKP-1 /kinetics/chain/kinetics[3]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK* /kinetics/chain/kinetics[3]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MKP-1 /kinetics/chain/kinetics[3]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[3]/MKP-1 /kinetics/chain/kinetics[3]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MKP-1 /kinetics/chain/kinetics[3]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[3]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[3]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[3]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[3]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[2]/PPhosphatase2A/diff /kinetics/chain/kinetics[3]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/diff /kinetics/chain/kinetics[3]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1* /kinetics/chain/kinetics[3]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A /kinetics/chain/kinetics[3]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK* /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1** /kinetics/chain/kinetics[3]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A /kinetics/chain/kinetics[3]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A /kinetics/chain/kinetics[3]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A /kinetics/chain/kinetics[3]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[3]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM/diff /kinetics/chain/kinetics[3]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[3]/CaM/CaM/diff /kinetics/chain/kinetics[3]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM /kinetics/chain/kinetics[3]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM /kinetics/chain/kinetics[3]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ca /kinetics/chain/kinetics[3]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ca /kinetics/chain/kinetics[3]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM /kinetics/chain/kinetics[3]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[3]/CaM/CaM-TR2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ca /kinetics/chain/kinetics[3]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca3 /kinetics/chain/kinetics[3]/CaM/CaM-TR2-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[3]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca3 /kinetics/chain/kinetics[3]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca4 /kinetics/chain/kinetics[3]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[3]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[3]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca3 /kinetics/chain/kinetics[3]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca3 /kinetics/chain/kinetics[3]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[3]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[3]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[3]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[2]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[3]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[3]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[3]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[3]/CaM/CaM-TR2-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[3]/CaM/CaM-TR2-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[3]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[3]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[2]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[3]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[3]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca4 /kinetics/chain/kinetics[3]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca4 /kinetics/chain/kinetics[3]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/MAPK/craf-1 /kinetics/chain/kinetics[3]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[3]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ras/GTP-Ras /kinetics/chain/kinetics[3]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[3]/Ca_diff /kinetics/chain/kinetics[3]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[3]/Ca /kinetics/chain/kinetics[3]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[3]/Ca_input /kinetics/chain/kinetics[3]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[4]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[4]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[4]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[4]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[4]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[4]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca /kinetics/chain/kinetics[4]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca /kinetics/chain/kinetics[4]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ca /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca /kinetics/chain/kinetics[4]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[4]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[4]/DAG /kinetics/chain/kinetics[4]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca /kinetics/chain/kinetics[4]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[4]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[4]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[4]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca-AA PRODUCT n addmsg /kinetics/chain/kinetics[4]/AA /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[4]/PKC/PKC-act-by-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[4]/PKC/PKC-act-by-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[4]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[4]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[4]/PKC/PKC-DAG-AA* REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[4]/PKC/PKC-DAG-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[4]/PKC/PKC-DAG-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[4]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[4]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[4]/PKC/PKC-Ca-AA* REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[4]/PKC/PKC-Ca-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[4]/PKC/PKC-Ca-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-basal-act /kinetics/chain/kinetics[4]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[4]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[4]/PKC/PKC-basal* REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-basal* /kinetics/chain/kinetics[4]/PKC/PKC-basal*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-basal* /kinetics/chain/kinetics[4]/PKC/PKC-basal*/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-basal* /kinetics/chain/kinetics[4]/PKC/PKC-basal-act PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic /kinetics/chain/kinetics[4]/PKC/PKC-basal-act SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[4]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[4]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[4]/PKC/PKC-AA* REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-AA* /kinetics/chain/kinetics[4]/PKC/PKC-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-AA* /kinetics/chain/kinetics[4]/PKC/PKC-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-AA* /kinetics/chain/kinetics[4]/PKC/PKC-act-by-AA PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic /kinetics/chain/kinetics[4]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/AA /kinetics/chain/kinetics[4]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/DAG /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG /kinetics/chain/kinetics[4]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[4]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[4]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[4]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG /kinetics/chain/kinetics[4]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG /kinetics/chain/kinetics[4]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[4]/AA /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[4]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[4]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[3]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[4]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[4]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[4]/PKC/PKC-DAG-AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[4]/PKC/PKC-DAG-AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-basal-act /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[4]/AA REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[4]/AA REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[4]/AA REAC A B addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[4]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[4]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[4]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[4]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[4]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[4]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[4]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[4]/PLA2/Degrade-AA /kinetics/chain/kinetics[4]/AA REAC A B addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[4]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[3]/AA/diff /kinetics/chain/kinetics[4]/AA REAC B A addmsg /kinetics/chain/kinetics[4]/AA/diff /kinetics/chain/kinetics[4]/AA REAC A B addmsg /kinetics/chain/kinetics[4]/AA /kinetics/chain/kinetics[4]/AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/AA /kinetics/chain/kinetics[4]/AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[4]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[4]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[4]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[4]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[4]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[4]/MAPK*/MAPK* /kinetics/chain/kinetics[4]/PLA2/PLA2-cytosolic REAC sA B addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[4]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[4]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[4]/PLA2/PLA2-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[4]/PLA2/PLA2-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ca /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca* REAC eA B addmsg /kinetics/chain/kinetics[4]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[4]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca*/kenz ENZYME n addmsg /kinetics/chain/kinetics[4]/PLA2/APC /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca*/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[4]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[4]/PLA2/PIP2-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[4]/temp-PIP2 /kinetics/chain/kinetics[4]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[4]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[4]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[4]/PLA2/PIP2-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[3]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[4]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[4]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[4]/PLA2/PIP2-PLA2* REAC A B addmsg /kinetics/chain/kinetics[4]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[4]/PLA2/PIP2-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[4]/PLA2/APC /kinetics/chain/kinetics[4]/PLA2/PIP2-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[4]/PLA2/PIP2-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[4]/PLA2/PIP2-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[4]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[4]/PLA2/PIP2-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[4]/temp-PIP2 /kinetics/chain/kinetics[4]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[4]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[4]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[4]/PLA2/PIP2-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[3]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[4]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[4]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[4]/PLA2/PIP2-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[4]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[4]/PLA2/PIP2-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[4]/PLA2/APC /kinetics/chain/kinetics[4]/PLA2/PIP2-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[4]/PLA2/PIP2-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[4]/PLA2/PIP2-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[4]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[4]/PLA2/DAG-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[4]/DAG /kinetics/chain/kinetics[4]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[4]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[4]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[4]/PLA2/DAG-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[3]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[4]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[4]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[4]/PLA2/DAG-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[4]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[4]/PLA2/DAG-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[4]/PLA2/APC /kinetics/chain/kinetics[4]/PLA2/DAG-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[4]/PLA2/DAG-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[4]/PLA2/DAG-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[4]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[4]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[4]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[4]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[4]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[4]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[4]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[4]/PLA2/Degrade-AA /kinetics/chain/kinetics[4]/PLA2/APC REAC B A addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[4]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[4]/AA /kinetics/chain/kinetics[4]/PLA2/Degrade-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PLA2/APC /kinetics/chain/kinetics[4]/PLA2/Degrade-AA PRODUCT n addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca REAC eA B addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca REAC A B addmsg /kinetics/chain/kinetics[4]/PLA2/APC /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca/kenz ENZYME n addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[4]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[4]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[4]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[4]/MAPK*/MAPK* /kinetics/chain/kinetics[4]/PLA2/PLA2* MM_PRD pA addmsg /kinetics/chain/kinetics[3]/PLA2/PLA2*/diff /kinetics/chain/kinetics[4]/PLA2/PLA2* REAC B A addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2*/diff /kinetics/chain/kinetics[4]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2* /kinetics/chain/kinetics[4]/PLA2/PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2* /kinetics/chain/kinetics[4]/PLA2/PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2* /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ca /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[4]/PLA2/dephosphorylate-PLA2* PRODUCT n addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2* /kinetics/chain/kinetics[4]/PLA2/dephosphorylate-PLA2* SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[4]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[4]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[4]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[4]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[4]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[4]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[4]/Ras-act-unphosph-raf /kinetics/chain/kinetics[4]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[4]/Ras-act-craf /kinetics/chain/kinetics[4]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[4]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[4]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[4]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[4]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[4]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[4]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[4]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[4]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[4]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[4]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[4]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK/diff /kinetics/chain/kinetics[4]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK/diff /kinetics/chain/kinetics[4]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK /kinetics/chain/kinetics[4]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK /kinetics/chain/kinetics[4]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[4]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[4]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[4]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[4]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[4]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[4]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[4]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[4]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[4]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK* /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK* /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[4]/Ras-act-unphosph-raf /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[4]/Ras-act-craf /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1* /kinetics/chain/kinetics[4]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[4]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ras/GTP-Ras /kinetics/chain/kinetics[4]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF /kinetics/chain/kinetics[4]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ras/GEF* /kinetics/chain/kinetics[4]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/dephosph-GEF /kinetics/chain/kinetics[4]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[4]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[4]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[4]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[4]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[4]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[3]/Ras/inact-GEF/diff /kinetics/chain/kinetics[4]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF/diff /kinetics/chain/kinetics[4]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF /kinetics/chain/kinetics[4]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[4]/Ras/GDP-Ras /kinetics/chain/kinetics[4]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF /kinetics/chain/kinetics[4]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF /kinetics/chain/kinetics[4]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ras/dephosph-GEF /kinetics/chain/kinetics[4]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[4]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[4]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[4]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[3]/Ras/GEF*/diff /kinetics/chain/kinetics[4]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[4]/Ras/GEF*/diff /kinetics/chain/kinetics[4]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/GEF* /kinetics/chain/kinetics[4]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[4]/Ras/GDP-Ras /kinetics/chain/kinetics[4]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/GEF* /kinetics/chain/kinetics[4]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/GEF* /kinetics/chain/kinetics[4]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ras-act-craf /kinetics/chain/kinetics[4]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[4]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[4]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[4]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[4]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[4]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[4]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[4]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[4]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[4]/Ras-act-unphosph-raf /kinetics/chain/kinetics[4]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[4]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[4]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[4]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[4]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[4]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[4]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[4]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[4]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[4]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[4]/Ras/GTP-Ras /kinetics/chain/kinetics[4]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/GDP-Ras /kinetics/chain/kinetics[4]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ras/GAP* /kinetics/chain/kinetics[4]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/GAP /kinetics/chain/kinetics[4]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ras/dephosph-GAP /kinetics/chain/kinetics[4]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[4]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[4]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[3]/Ras/GAP*/diff /kinetics/chain/kinetics[4]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[4]/Ras/GAP*/diff /kinetics/chain/kinetics[4]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/GAP* /kinetics/chain/kinetics[4]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/GAP* /kinetics/chain/kinetics[4]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ras/dephosph-GAP /kinetics/chain/kinetics[4]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[4]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[4]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[4]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[4]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[3]/Ras/GAP/diff /kinetics/chain/kinetics[4]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[4]/Ras/GAP/diff /kinetics/chain/kinetics[4]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/GTP-Ras /kinetics/chain/kinetics[4]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/GAP /kinetics/chain/kinetics[4]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[4]/Ras/GAP /kinetics/chain/kinetics[4]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/GAP /kinetics/chain/kinetics[4]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF /kinetics/chain/kinetics[4]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/CaM-GEF /kinetics/chain/kinetics[4]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca4 /kinetics/chain/kinetics[4]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[4]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[4]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[4]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[3]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[4]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[4]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[4]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[4]/Ras/GDP-Ras /kinetics/chain/kinetics[4]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ras/CaM-GEF /kinetics/chain/kinetics[4]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[4]/Ras/CaM-GEF /kinetics/chain/kinetics[4]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/CaM-GEF /kinetics/chain/kinetics[4]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[4]/Ca REAC A B addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[4]/Ca REAC A B addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[4]/Ca REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[4]/Ca REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[4]/Ca REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[4]/Ca REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[4]/Ca REAC A B addmsg /kinetics/chain/kinetics[4]/Ca_diff /kinetics/chain/kinetics[4]/Ca REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[4]/DAG REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG /kinetics/chain/kinetics[4]/DAG REAC A B addmsg /kinetics/chain/kinetics[4]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[4]/DAG REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[4]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[4]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[4]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[4]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[4]/PKC/PKC-basal* /kinetics/chain/kinetics[4]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[4]/PKC/PKC-AA* /kinetics/chain/kinetics[4]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[4]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[4]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[4]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[4]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[4]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[4]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[4]/PKC-active/phosph-AC2 /kinetics/chain/kinetics[4]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1 /kinetics/chain/kinetics[4]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC-active /kinetics/chain/kinetics[4]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[4]/Ras/GAP /kinetics/chain/kinetics[4]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC-active /kinetics/chain/kinetics[4]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF /kinetics/chain/kinetics[4]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PKC-active /kinetics/chain/kinetics[4]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[4]/PKC-active /kinetics/chain/kinetics[4]/PKC-active/phosph-AC2 ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[4]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MAPK*/MAPK* /kinetics/chain/kinetics[4]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[4]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[4]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[4]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[4]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[3]/MAPK*/diff /kinetics/chain/kinetics[4]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[4]/MAPK*/diff /kinetics/chain/kinetics[4]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[4]/MAPK*/MAPK* SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK* /kinetics/chain/kinetics[4]/MAPK*/MAPK* ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1* /kinetics/chain/kinetics[4]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK* /kinetics/chain/kinetics[4]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK* /kinetics/chain/kinetics[4]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK* /kinetics/chain/kinetics[4]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[4]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[4]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[4]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[3]/MKP-1/diff /kinetics/chain/kinetics[4]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[4]/MKP-1/diff /kinetics/chain/kinetics[4]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr /kinetics/chain/kinetics[4]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MKP-1 /kinetics/chain/kinetics[4]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK* /kinetics/chain/kinetics[4]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MKP-1 /kinetics/chain/kinetics[4]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[4]/MKP-1 /kinetics/chain/kinetics[4]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MKP-1 /kinetics/chain/kinetics[4]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[4]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[4]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[4]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[4]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[3]/PPhosphatase2A/diff /kinetics/chain/kinetics[4]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/diff /kinetics/chain/kinetics[4]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1* /kinetics/chain/kinetics[4]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A /kinetics/chain/kinetics[4]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK* /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1** /kinetics/chain/kinetics[4]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A /kinetics/chain/kinetics[4]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A /kinetics/chain/kinetics[4]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A /kinetics/chain/kinetics[4]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[4]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM/diff /kinetics/chain/kinetics[4]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[4]/CaM/CaM/diff /kinetics/chain/kinetics[4]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM /kinetics/chain/kinetics[4]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM /kinetics/chain/kinetics[4]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ca /kinetics/chain/kinetics[4]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ca /kinetics/chain/kinetics[4]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM /kinetics/chain/kinetics[4]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[4]/CaM/CaM-TR2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ca /kinetics/chain/kinetics[4]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca3 /kinetics/chain/kinetics[4]/CaM/CaM-TR2-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[4]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca3 /kinetics/chain/kinetics[4]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca4 /kinetics/chain/kinetics[4]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[4]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[4]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca3 /kinetics/chain/kinetics[4]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca3 /kinetics/chain/kinetics[4]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[4]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[4]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[4]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[3]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[4]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[4]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[4]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[4]/CaM/CaM-TR2-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[4]/CaM/CaM-TR2-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[4]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[4]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[3]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[4]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[4]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca4 /kinetics/chain/kinetics[4]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca4 /kinetics/chain/kinetics[4]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/MAPK/craf-1 /kinetics/chain/kinetics[4]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[4]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ras/GTP-Ras /kinetics/chain/kinetics[4]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[4]/Ca_diff /kinetics/chain/kinetics[4]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[4]/Ca /kinetics/chain/kinetics[4]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[4]/Ca_input /kinetics/chain/kinetics[4]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[5]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[5]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[5]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[5]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[5]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[5]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca /kinetics/chain/kinetics[5]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca /kinetics/chain/kinetics[5]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ca /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca /kinetics/chain/kinetics[5]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[5]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[5]/DAG /kinetics/chain/kinetics[5]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca /kinetics/chain/kinetics[5]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[5]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[5]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[5]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca-AA PRODUCT n addmsg /kinetics/chain/kinetics[5]/AA /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[5]/PKC/PKC-act-by-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[5]/PKC/PKC-act-by-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[5]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[5]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[5]/PKC/PKC-DAG-AA* REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[5]/PKC/PKC-DAG-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[5]/PKC/PKC-DAG-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[5]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[5]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[5]/PKC/PKC-Ca-AA* REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[5]/PKC/PKC-Ca-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[5]/PKC/PKC-Ca-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-basal-act /kinetics/chain/kinetics[5]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[5]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[5]/PKC/PKC-basal* REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-basal* /kinetics/chain/kinetics[5]/PKC/PKC-basal*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-basal* /kinetics/chain/kinetics[5]/PKC/PKC-basal*/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-basal* /kinetics/chain/kinetics[5]/PKC/PKC-basal-act PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic /kinetics/chain/kinetics[5]/PKC/PKC-basal-act SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[5]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[5]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[5]/PKC/PKC-AA* REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-AA* /kinetics/chain/kinetics[5]/PKC/PKC-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-AA* /kinetics/chain/kinetics[5]/PKC/PKC-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-AA* /kinetics/chain/kinetics[5]/PKC/PKC-act-by-AA PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic /kinetics/chain/kinetics[5]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/AA /kinetics/chain/kinetics[5]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/DAG /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG /kinetics/chain/kinetics[5]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[5]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[5]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[5]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG /kinetics/chain/kinetics[5]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG /kinetics/chain/kinetics[5]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[5]/AA /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[5]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[5]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[4]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[5]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[5]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[5]/PKC/PKC-DAG-AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[5]/PKC/PKC-DAG-AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-basal-act /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[5]/AA REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[5]/AA REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[5]/AA REAC A B addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[5]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[5]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[5]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[5]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[5]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[5]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[5]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[5]/PLA2/Degrade-AA /kinetics/chain/kinetics[5]/AA REAC A B addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[5]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[4]/AA/diff /kinetics/chain/kinetics[5]/AA REAC B A addmsg /kinetics/chain/kinetics[5]/AA/diff /kinetics/chain/kinetics[5]/AA REAC A B addmsg /kinetics/chain/kinetics[5]/AA /kinetics/chain/kinetics[5]/AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/AA /kinetics/chain/kinetics[5]/AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[5]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[5]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[5]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[5]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[5]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[5]/MAPK*/MAPK* /kinetics/chain/kinetics[5]/PLA2/PLA2-cytosolic REAC sA B addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[5]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[5]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[5]/PLA2/PLA2-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[5]/PLA2/PLA2-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ca /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca* REAC eA B addmsg /kinetics/chain/kinetics[5]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[5]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca*/kenz ENZYME n addmsg /kinetics/chain/kinetics[5]/PLA2/APC /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca*/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[5]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[5]/PLA2/PIP2-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[5]/temp-PIP2 /kinetics/chain/kinetics[5]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[5]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[5]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[5]/PLA2/PIP2-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[4]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[5]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[5]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[5]/PLA2/PIP2-PLA2* REAC A B addmsg /kinetics/chain/kinetics[5]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[5]/PLA2/PIP2-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[5]/PLA2/APC /kinetics/chain/kinetics[5]/PLA2/PIP2-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[5]/PLA2/PIP2-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[5]/PLA2/PIP2-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[5]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[5]/PLA2/PIP2-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[5]/temp-PIP2 /kinetics/chain/kinetics[5]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[5]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[5]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[5]/PLA2/PIP2-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[4]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[5]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[5]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[5]/PLA2/PIP2-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[5]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[5]/PLA2/PIP2-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[5]/PLA2/APC /kinetics/chain/kinetics[5]/PLA2/PIP2-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[5]/PLA2/PIP2-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[5]/PLA2/PIP2-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[5]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[5]/PLA2/DAG-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[5]/DAG /kinetics/chain/kinetics[5]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[5]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[5]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[5]/PLA2/DAG-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[4]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[5]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[5]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[5]/PLA2/DAG-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[5]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[5]/PLA2/DAG-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[5]/PLA2/APC /kinetics/chain/kinetics[5]/PLA2/DAG-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[5]/PLA2/DAG-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[5]/PLA2/DAG-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[5]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[5]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[5]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[5]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[5]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[5]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[5]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[5]/PLA2/Degrade-AA /kinetics/chain/kinetics[5]/PLA2/APC REAC B A addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[5]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[5]/AA /kinetics/chain/kinetics[5]/PLA2/Degrade-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PLA2/APC /kinetics/chain/kinetics[5]/PLA2/Degrade-AA PRODUCT n addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca REAC eA B addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca REAC A B addmsg /kinetics/chain/kinetics[5]/PLA2/APC /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca/kenz ENZYME n addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[5]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[5]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[5]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[5]/MAPK*/MAPK* /kinetics/chain/kinetics[5]/PLA2/PLA2* MM_PRD pA addmsg /kinetics/chain/kinetics[4]/PLA2/PLA2*/diff /kinetics/chain/kinetics[5]/PLA2/PLA2* REAC B A addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2*/diff /kinetics/chain/kinetics[5]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2* /kinetics/chain/kinetics[5]/PLA2/PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2* /kinetics/chain/kinetics[5]/PLA2/PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2* /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ca /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[5]/PLA2/dephosphorylate-PLA2* PRODUCT n addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2* /kinetics/chain/kinetics[5]/PLA2/dephosphorylate-PLA2* SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[5]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[5]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[5]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[5]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[5]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[5]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[5]/Ras-act-unphosph-raf /kinetics/chain/kinetics[5]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[5]/Ras-act-craf /kinetics/chain/kinetics[5]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[5]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[5]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[5]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[5]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[5]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[5]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[5]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[5]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[5]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[5]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[5]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK/diff /kinetics/chain/kinetics[5]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK/diff /kinetics/chain/kinetics[5]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK /kinetics/chain/kinetics[5]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK /kinetics/chain/kinetics[5]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[5]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[5]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[5]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[5]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[5]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[5]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[5]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[5]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[5]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK* /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK* /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[5]/Ras-act-unphosph-raf /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[5]/Ras-act-craf /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1* /kinetics/chain/kinetics[5]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[5]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ras/GTP-Ras /kinetics/chain/kinetics[5]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF /kinetics/chain/kinetics[5]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ras/GEF* /kinetics/chain/kinetics[5]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/dephosph-GEF /kinetics/chain/kinetics[5]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[5]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[5]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[5]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[5]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[5]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[4]/Ras/inact-GEF/diff /kinetics/chain/kinetics[5]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF/diff /kinetics/chain/kinetics[5]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF /kinetics/chain/kinetics[5]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[5]/Ras/GDP-Ras /kinetics/chain/kinetics[5]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF /kinetics/chain/kinetics[5]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF /kinetics/chain/kinetics[5]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ras/dephosph-GEF /kinetics/chain/kinetics[5]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[5]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[5]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[5]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[4]/Ras/GEF*/diff /kinetics/chain/kinetics[5]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[5]/Ras/GEF*/diff /kinetics/chain/kinetics[5]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/GEF* /kinetics/chain/kinetics[5]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[5]/Ras/GDP-Ras /kinetics/chain/kinetics[5]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/GEF* /kinetics/chain/kinetics[5]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/GEF* /kinetics/chain/kinetics[5]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ras-act-craf /kinetics/chain/kinetics[5]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[5]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[5]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[5]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[5]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[5]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[5]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[5]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[5]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[5]/Ras-act-unphosph-raf /kinetics/chain/kinetics[5]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[5]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[5]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[5]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[5]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[5]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[5]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[5]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[5]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[5]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[5]/Ras/GTP-Ras /kinetics/chain/kinetics[5]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/GDP-Ras /kinetics/chain/kinetics[5]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ras/GAP* /kinetics/chain/kinetics[5]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/GAP /kinetics/chain/kinetics[5]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ras/dephosph-GAP /kinetics/chain/kinetics[5]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[5]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[5]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[4]/Ras/GAP*/diff /kinetics/chain/kinetics[5]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[5]/Ras/GAP*/diff /kinetics/chain/kinetics[5]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/GAP* /kinetics/chain/kinetics[5]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/GAP* /kinetics/chain/kinetics[5]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ras/dephosph-GAP /kinetics/chain/kinetics[5]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[5]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[5]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[5]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[5]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[4]/Ras/GAP/diff /kinetics/chain/kinetics[5]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[5]/Ras/GAP/diff /kinetics/chain/kinetics[5]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/GTP-Ras /kinetics/chain/kinetics[5]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/GAP /kinetics/chain/kinetics[5]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[5]/Ras/GAP /kinetics/chain/kinetics[5]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/GAP /kinetics/chain/kinetics[5]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF /kinetics/chain/kinetics[5]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/CaM-GEF /kinetics/chain/kinetics[5]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca4 /kinetics/chain/kinetics[5]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[5]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[5]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[5]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[4]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[5]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[5]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[5]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[5]/Ras/GDP-Ras /kinetics/chain/kinetics[5]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ras/CaM-GEF /kinetics/chain/kinetics[5]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[5]/Ras/CaM-GEF /kinetics/chain/kinetics[5]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/CaM-GEF /kinetics/chain/kinetics[5]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[5]/Ca REAC A B addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[5]/Ca REAC A B addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[5]/Ca REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[5]/Ca REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[5]/Ca REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[5]/Ca REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[5]/Ca REAC A B addmsg /kinetics/chain/kinetics[5]/Ca_diff /kinetics/chain/kinetics[5]/Ca REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[5]/DAG REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG /kinetics/chain/kinetics[5]/DAG REAC A B addmsg /kinetics/chain/kinetics[5]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[5]/DAG REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[5]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[5]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[5]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[5]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[5]/PKC/PKC-basal* /kinetics/chain/kinetics[5]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[5]/PKC/PKC-AA* /kinetics/chain/kinetics[5]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[5]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[5]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[5]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[5]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[5]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[5]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[5]/PKC-active/phosph-AC2 /kinetics/chain/kinetics[5]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1 /kinetics/chain/kinetics[5]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC-active /kinetics/chain/kinetics[5]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[5]/Ras/GAP /kinetics/chain/kinetics[5]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC-active /kinetics/chain/kinetics[5]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF /kinetics/chain/kinetics[5]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PKC-active /kinetics/chain/kinetics[5]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[5]/PKC-active /kinetics/chain/kinetics[5]/PKC-active/phosph-AC2 ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[5]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MAPK*/MAPK* /kinetics/chain/kinetics[5]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[5]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[5]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[5]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[5]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[4]/MAPK*/diff /kinetics/chain/kinetics[5]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[5]/MAPK*/diff /kinetics/chain/kinetics[5]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[5]/MAPK*/MAPK* SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK* /kinetics/chain/kinetics[5]/MAPK*/MAPK* ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1* /kinetics/chain/kinetics[5]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK* /kinetics/chain/kinetics[5]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK* /kinetics/chain/kinetics[5]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK* /kinetics/chain/kinetics[5]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[5]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[5]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[5]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[4]/MKP-1/diff /kinetics/chain/kinetics[5]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[5]/MKP-1/diff /kinetics/chain/kinetics[5]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr /kinetics/chain/kinetics[5]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MKP-1 /kinetics/chain/kinetics[5]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK* /kinetics/chain/kinetics[5]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MKP-1 /kinetics/chain/kinetics[5]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[5]/MKP-1 /kinetics/chain/kinetics[5]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MKP-1 /kinetics/chain/kinetics[5]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[5]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[5]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[5]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[5]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[4]/PPhosphatase2A/diff /kinetics/chain/kinetics[5]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/diff /kinetics/chain/kinetics[5]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1* /kinetics/chain/kinetics[5]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A /kinetics/chain/kinetics[5]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK* /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1** /kinetics/chain/kinetics[5]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A /kinetics/chain/kinetics[5]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A /kinetics/chain/kinetics[5]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A /kinetics/chain/kinetics[5]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[5]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM/diff /kinetics/chain/kinetics[5]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[5]/CaM/CaM/diff /kinetics/chain/kinetics[5]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM /kinetics/chain/kinetics[5]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM /kinetics/chain/kinetics[5]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ca /kinetics/chain/kinetics[5]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ca /kinetics/chain/kinetics[5]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM /kinetics/chain/kinetics[5]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[5]/CaM/CaM-TR2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ca /kinetics/chain/kinetics[5]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca3 /kinetics/chain/kinetics[5]/CaM/CaM-TR2-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[5]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca3 /kinetics/chain/kinetics[5]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca4 /kinetics/chain/kinetics[5]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[5]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[5]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca3 /kinetics/chain/kinetics[5]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca3 /kinetics/chain/kinetics[5]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[5]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[5]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[5]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[4]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[5]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[5]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[5]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[5]/CaM/CaM-TR2-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[5]/CaM/CaM-TR2-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[5]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[5]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[4]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[5]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[5]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca4 /kinetics/chain/kinetics[5]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 /kinetics/chain/kinetics[5]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/MAPK/craf-1 /kinetics/chain/kinetics[5]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[5]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ras/GTP-Ras /kinetics/chain/kinetics[5]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[5]/Ca_diff /kinetics/chain/kinetics[5]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[5]/Ca /kinetics/chain/kinetics[5]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[5]/Ca_input /kinetics/chain/kinetics[5]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[6]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[6]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[6]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[6]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[6]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[6]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca /kinetics/chain/kinetics[6]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca /kinetics/chain/kinetics[6]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ca /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca /kinetics/chain/kinetics[6]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[6]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[6]/DAG /kinetics/chain/kinetics[6]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca /kinetics/chain/kinetics[6]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[6]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[6]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[6]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca-AA PRODUCT n addmsg /kinetics/chain/kinetics[6]/AA /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[6]/PKC/PKC-act-by-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[6]/PKC/PKC-act-by-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[6]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[6]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[6]/PKC/PKC-DAG-AA* REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[6]/PKC/PKC-DAG-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[6]/PKC/PKC-DAG-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[6]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[6]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[6]/PKC/PKC-Ca-AA* REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[6]/PKC/PKC-Ca-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[6]/PKC/PKC-Ca-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-basal-act /kinetics/chain/kinetics[6]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[6]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[6]/PKC/PKC-basal* REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-basal* /kinetics/chain/kinetics[6]/PKC/PKC-basal*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-basal* /kinetics/chain/kinetics[6]/PKC/PKC-basal*/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-basal* /kinetics/chain/kinetics[6]/PKC/PKC-basal-act PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic /kinetics/chain/kinetics[6]/PKC/PKC-basal-act SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[6]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[6]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[6]/PKC/PKC-AA* REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-AA* /kinetics/chain/kinetics[6]/PKC/PKC-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-AA* /kinetics/chain/kinetics[6]/PKC/PKC-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-AA* /kinetics/chain/kinetics[6]/PKC/PKC-act-by-AA PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic /kinetics/chain/kinetics[6]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/AA /kinetics/chain/kinetics[6]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/DAG /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG /kinetics/chain/kinetics[6]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[6]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[6]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[6]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG /kinetics/chain/kinetics[6]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG /kinetics/chain/kinetics[6]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[6]/AA /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[6]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[6]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[5]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[6]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[6]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[6]/PKC/PKC-DAG-AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[6]/PKC/PKC-DAG-AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-basal-act /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[6]/AA REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[6]/AA REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[6]/AA REAC A B addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[6]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[6]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[6]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[6]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[6]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[6]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[6]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[6]/PLA2/Degrade-AA /kinetics/chain/kinetics[6]/AA REAC A B addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[6]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[5]/AA/diff /kinetics/chain/kinetics[6]/AA REAC B A addmsg /kinetics/chain/kinetics[6]/AA/diff /kinetics/chain/kinetics[6]/AA REAC A B addmsg /kinetics/chain/kinetics[6]/AA /kinetics/chain/kinetics[6]/AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/AA /kinetics/chain/kinetics[6]/AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[6]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[6]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[6]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[6]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[6]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[6]/MAPK*/MAPK* /kinetics/chain/kinetics[6]/PLA2/PLA2-cytosolic REAC sA B addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[6]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[6]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[6]/PLA2/PLA2-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[6]/PLA2/PLA2-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ca /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca* REAC eA B addmsg /kinetics/chain/kinetics[6]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[6]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca*/kenz ENZYME n addmsg /kinetics/chain/kinetics[6]/PLA2/APC /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca*/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[6]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[6]/PLA2/PIP2-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[6]/temp-PIP2 /kinetics/chain/kinetics[6]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[6]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[6]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[6]/PLA2/PIP2-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[5]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[6]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[6]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[6]/PLA2/PIP2-PLA2* REAC A B addmsg /kinetics/chain/kinetics[6]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[6]/PLA2/PIP2-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[6]/PLA2/APC /kinetics/chain/kinetics[6]/PLA2/PIP2-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[6]/PLA2/PIP2-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[6]/PLA2/PIP2-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[6]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[6]/PLA2/PIP2-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[6]/temp-PIP2 /kinetics/chain/kinetics[6]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[6]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[6]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[6]/PLA2/PIP2-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[5]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[6]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[6]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[6]/PLA2/PIP2-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[6]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[6]/PLA2/PIP2-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[6]/PLA2/APC /kinetics/chain/kinetics[6]/PLA2/PIP2-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[6]/PLA2/PIP2-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[6]/PLA2/PIP2-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[6]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[6]/PLA2/DAG-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[6]/DAG /kinetics/chain/kinetics[6]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[6]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[6]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[6]/PLA2/DAG-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[5]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[6]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[6]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[6]/PLA2/DAG-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[6]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[6]/PLA2/DAG-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[6]/PLA2/APC /kinetics/chain/kinetics[6]/PLA2/DAG-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[6]/PLA2/DAG-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[6]/PLA2/DAG-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[6]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[6]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[6]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[6]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[6]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[6]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[6]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[6]/PLA2/Degrade-AA /kinetics/chain/kinetics[6]/PLA2/APC REAC B A addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[6]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[6]/AA /kinetics/chain/kinetics[6]/PLA2/Degrade-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PLA2/APC /kinetics/chain/kinetics[6]/PLA2/Degrade-AA PRODUCT n addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca REAC eA B addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca REAC A B addmsg /kinetics/chain/kinetics[6]/PLA2/APC /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca/kenz ENZYME n addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[6]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[6]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[6]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[6]/MAPK*/MAPK* /kinetics/chain/kinetics[6]/PLA2/PLA2* MM_PRD pA addmsg /kinetics/chain/kinetics[5]/PLA2/PLA2*/diff /kinetics/chain/kinetics[6]/PLA2/PLA2* REAC B A addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2*/diff /kinetics/chain/kinetics[6]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2* /kinetics/chain/kinetics[6]/PLA2/PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2* /kinetics/chain/kinetics[6]/PLA2/PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2* /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ca /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[6]/PLA2/dephosphorylate-PLA2* PRODUCT n addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2* /kinetics/chain/kinetics[6]/PLA2/dephosphorylate-PLA2* SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[6]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[6]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[6]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[6]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[6]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[6]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[6]/Ras-act-unphosph-raf /kinetics/chain/kinetics[6]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[6]/Ras-act-craf /kinetics/chain/kinetics[6]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[6]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[6]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[6]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[6]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[6]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[6]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[6]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[6]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[6]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[6]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[6]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK/diff /kinetics/chain/kinetics[6]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK/diff /kinetics/chain/kinetics[6]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK /kinetics/chain/kinetics[6]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK /kinetics/chain/kinetics[6]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[6]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[6]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[6]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[6]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[6]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[6]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[6]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[6]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[6]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK* /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK* /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[6]/Ras-act-unphosph-raf /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[6]/Ras-act-craf /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1* /kinetics/chain/kinetics[6]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[6]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ras/GTP-Ras /kinetics/chain/kinetics[6]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF /kinetics/chain/kinetics[6]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ras/GEF* /kinetics/chain/kinetics[6]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/dephosph-GEF /kinetics/chain/kinetics[6]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[6]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[6]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[6]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[6]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[6]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[5]/Ras/inact-GEF/diff /kinetics/chain/kinetics[6]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF/diff /kinetics/chain/kinetics[6]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF /kinetics/chain/kinetics[6]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[6]/Ras/GDP-Ras /kinetics/chain/kinetics[6]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF /kinetics/chain/kinetics[6]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF /kinetics/chain/kinetics[6]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ras/dephosph-GEF /kinetics/chain/kinetics[6]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[6]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[6]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[6]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[5]/Ras/GEF*/diff /kinetics/chain/kinetics[6]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[6]/Ras/GEF*/diff /kinetics/chain/kinetics[6]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/GEF* /kinetics/chain/kinetics[6]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[6]/Ras/GDP-Ras /kinetics/chain/kinetics[6]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/GEF* /kinetics/chain/kinetics[6]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/GEF* /kinetics/chain/kinetics[6]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ras-act-craf /kinetics/chain/kinetics[6]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[6]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[6]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[6]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[6]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[6]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[6]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[6]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[6]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[6]/Ras-act-unphosph-raf /kinetics/chain/kinetics[6]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[6]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[6]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[6]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[6]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[6]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[6]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[6]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[6]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[6]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[6]/Ras/GTP-Ras /kinetics/chain/kinetics[6]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/GDP-Ras /kinetics/chain/kinetics[6]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ras/GAP* /kinetics/chain/kinetics[6]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/GAP /kinetics/chain/kinetics[6]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ras/dephosph-GAP /kinetics/chain/kinetics[6]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[6]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[6]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[5]/Ras/GAP*/diff /kinetics/chain/kinetics[6]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[6]/Ras/GAP*/diff /kinetics/chain/kinetics[6]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/GAP* /kinetics/chain/kinetics[6]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/GAP* /kinetics/chain/kinetics[6]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ras/dephosph-GAP /kinetics/chain/kinetics[6]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[6]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[6]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[6]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[6]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[5]/Ras/GAP/diff /kinetics/chain/kinetics[6]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[6]/Ras/GAP/diff /kinetics/chain/kinetics[6]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/GTP-Ras /kinetics/chain/kinetics[6]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/GAP /kinetics/chain/kinetics[6]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[6]/Ras/GAP /kinetics/chain/kinetics[6]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/GAP /kinetics/chain/kinetics[6]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF /kinetics/chain/kinetics[6]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/CaM-GEF /kinetics/chain/kinetics[6]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 /kinetics/chain/kinetics[6]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[6]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[6]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[6]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[5]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[6]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[6]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[6]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[6]/Ras/GDP-Ras /kinetics/chain/kinetics[6]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ras/CaM-GEF /kinetics/chain/kinetics[6]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[6]/Ras/CaM-GEF /kinetics/chain/kinetics[6]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/CaM-GEF /kinetics/chain/kinetics[6]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[6]/Ca REAC A B addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[6]/Ca REAC A B addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[6]/Ca REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[6]/Ca REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[6]/Ca REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[6]/Ca REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[6]/Ca REAC A B addmsg /kinetics/chain/kinetics[6]/Ca_diff /kinetics/chain/kinetics[6]/Ca REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[6]/DAG REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG /kinetics/chain/kinetics[6]/DAG REAC A B addmsg /kinetics/chain/kinetics[6]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[6]/DAG REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[6]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[6]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[6]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[6]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[6]/PKC/PKC-basal* /kinetics/chain/kinetics[6]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[6]/PKC/PKC-AA* /kinetics/chain/kinetics[6]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[6]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[6]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[6]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[6]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[6]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[6]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[6]/PKC-active/phosph-AC2 /kinetics/chain/kinetics[6]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1 /kinetics/chain/kinetics[6]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC-active /kinetics/chain/kinetics[6]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[6]/Ras/GAP /kinetics/chain/kinetics[6]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC-active /kinetics/chain/kinetics[6]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF /kinetics/chain/kinetics[6]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PKC-active /kinetics/chain/kinetics[6]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[6]/PKC-active /kinetics/chain/kinetics[6]/PKC-active/phosph-AC2 ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[6]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MAPK*/MAPK* /kinetics/chain/kinetics[6]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[6]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[6]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[6]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[6]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[5]/MAPK*/diff /kinetics/chain/kinetics[6]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[6]/MAPK*/diff /kinetics/chain/kinetics[6]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[6]/MAPK*/MAPK* SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK* /kinetics/chain/kinetics[6]/MAPK*/MAPK* ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1* /kinetics/chain/kinetics[6]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK* /kinetics/chain/kinetics[6]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK* /kinetics/chain/kinetics[6]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK* /kinetics/chain/kinetics[6]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[6]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[6]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[6]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[5]/MKP-1/diff /kinetics/chain/kinetics[6]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[6]/MKP-1/diff /kinetics/chain/kinetics[6]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr /kinetics/chain/kinetics[6]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MKP-1 /kinetics/chain/kinetics[6]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK* /kinetics/chain/kinetics[6]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MKP-1 /kinetics/chain/kinetics[6]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[6]/MKP-1 /kinetics/chain/kinetics[6]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MKP-1 /kinetics/chain/kinetics[6]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[6]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[6]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[6]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[6]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[5]/PPhosphatase2A/diff /kinetics/chain/kinetics[6]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/diff /kinetics/chain/kinetics[6]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1* /kinetics/chain/kinetics[6]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A /kinetics/chain/kinetics[6]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK* /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1** /kinetics/chain/kinetics[6]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A /kinetics/chain/kinetics[6]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A /kinetics/chain/kinetics[6]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A /kinetics/chain/kinetics[6]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[6]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM/diff /kinetics/chain/kinetics[6]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[6]/CaM/CaM/diff /kinetics/chain/kinetics[6]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM /kinetics/chain/kinetics[6]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM /kinetics/chain/kinetics[6]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ca /kinetics/chain/kinetics[6]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ca /kinetics/chain/kinetics[6]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM /kinetics/chain/kinetics[6]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[6]/CaM/CaM-TR2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ca /kinetics/chain/kinetics[6]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca3 /kinetics/chain/kinetics[6]/CaM/CaM-TR2-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[6]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca3 /kinetics/chain/kinetics[6]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 /kinetics/chain/kinetics[6]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[6]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[6]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca3 /kinetics/chain/kinetics[6]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca3 /kinetics/chain/kinetics[6]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[6]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[6]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[6]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[5]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[6]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[6]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[6]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[6]/CaM/CaM-TR2-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[6]/CaM/CaM-TR2-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[5]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca4 /kinetics/chain/kinetics[6]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 /kinetics/chain/kinetics[6]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/MAPK/craf-1 /kinetics/chain/kinetics[6]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[6]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ras/GTP-Ras /kinetics/chain/kinetics[6]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[6]/Ca_diff /kinetics/chain/kinetics[6]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[6]/Ca /kinetics/chain/kinetics[6]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[6]/Ca_input /kinetics/chain/kinetics[6]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[7]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[7]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[7]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[7]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[7]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[7]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca /kinetics/chain/kinetics[7]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca /kinetics/chain/kinetics[7]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ca /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca /kinetics/chain/kinetics[7]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[7]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[7]/DAG /kinetics/chain/kinetics[7]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca /kinetics/chain/kinetics[7]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[7]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[7]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[7]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca-AA PRODUCT n addmsg /kinetics/chain/kinetics[7]/AA /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[7]/PKC/PKC-act-by-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[7]/PKC/PKC-act-by-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[7]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[7]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[7]/PKC/PKC-DAG-AA* REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[7]/PKC/PKC-DAG-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[7]/PKC/PKC-DAG-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[7]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[7]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[7]/PKC/PKC-Ca-AA* REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[7]/PKC/PKC-Ca-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[7]/PKC/PKC-Ca-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-basal-act /kinetics/chain/kinetics[7]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[7]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[7]/PKC/PKC-basal* REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-basal* /kinetics/chain/kinetics[7]/PKC/PKC-basal*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-basal* /kinetics/chain/kinetics[7]/PKC/PKC-basal*/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-basal* /kinetics/chain/kinetics[7]/PKC/PKC-basal-act PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic /kinetics/chain/kinetics[7]/PKC/PKC-basal-act SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[7]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[7]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[7]/PKC/PKC-AA* REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-AA* /kinetics/chain/kinetics[7]/PKC/PKC-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-AA* /kinetics/chain/kinetics[7]/PKC/PKC-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-AA* /kinetics/chain/kinetics[7]/PKC/PKC-act-by-AA PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic /kinetics/chain/kinetics[7]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/AA /kinetics/chain/kinetics[7]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/DAG /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG /kinetics/chain/kinetics[7]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[7]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[7]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[7]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG /kinetics/chain/kinetics[7]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG /kinetics/chain/kinetics[7]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[7]/AA /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[7]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[7]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[6]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[7]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[7]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[7]/PKC/PKC-DAG-AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[7]/PKC/PKC-DAG-AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-basal-act /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[7]/AA REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[7]/AA REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[7]/AA REAC A B addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[7]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[7]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[7]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[7]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[7]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[7]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[7]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[7]/PLA2/Degrade-AA /kinetics/chain/kinetics[7]/AA REAC A B addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[7]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[6]/AA/diff /kinetics/chain/kinetics[7]/AA REAC B A addmsg /kinetics/chain/kinetics[7]/AA/diff /kinetics/chain/kinetics[7]/AA REAC A B addmsg /kinetics/chain/kinetics[7]/AA /kinetics/chain/kinetics[7]/AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/AA /kinetics/chain/kinetics[7]/AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[7]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[7]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[7]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[7]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[7]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[7]/MAPK*/MAPK* /kinetics/chain/kinetics[7]/PLA2/PLA2-cytosolic REAC sA B addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[7]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[7]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[7]/PLA2/PLA2-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[7]/PLA2/PLA2-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ca /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca* REAC eA B addmsg /kinetics/chain/kinetics[7]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[7]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca*/kenz ENZYME n addmsg /kinetics/chain/kinetics[7]/PLA2/APC /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca*/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[7]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[7]/PLA2/PIP2-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[7]/temp-PIP2 /kinetics/chain/kinetics[7]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[7]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[7]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[7]/PLA2/PIP2-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[6]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[7]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[7]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[7]/PLA2/PIP2-PLA2* REAC A B addmsg /kinetics/chain/kinetics[7]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[7]/PLA2/PIP2-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[7]/PLA2/APC /kinetics/chain/kinetics[7]/PLA2/PIP2-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[7]/PLA2/PIP2-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[7]/PLA2/PIP2-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[7]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[7]/PLA2/PIP2-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[7]/temp-PIP2 /kinetics/chain/kinetics[7]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[7]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[7]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[7]/PLA2/PIP2-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[6]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[7]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[7]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[7]/PLA2/PIP2-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[7]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[7]/PLA2/PIP2-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[7]/PLA2/APC /kinetics/chain/kinetics[7]/PLA2/PIP2-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[7]/PLA2/PIP2-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[7]/PLA2/PIP2-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[7]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[7]/PLA2/DAG-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[7]/DAG /kinetics/chain/kinetics[7]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[7]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[7]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[7]/PLA2/DAG-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[6]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[7]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[7]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[7]/PLA2/DAG-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[7]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[7]/PLA2/DAG-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[7]/PLA2/APC /kinetics/chain/kinetics[7]/PLA2/DAG-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[7]/PLA2/DAG-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[7]/PLA2/DAG-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[7]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[7]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[7]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[7]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[7]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[7]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[7]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[7]/PLA2/Degrade-AA /kinetics/chain/kinetics[7]/PLA2/APC REAC B A addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[7]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[7]/AA /kinetics/chain/kinetics[7]/PLA2/Degrade-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PLA2/APC /kinetics/chain/kinetics[7]/PLA2/Degrade-AA PRODUCT n addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca REAC eA B addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca REAC A B addmsg /kinetics/chain/kinetics[7]/PLA2/APC /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca/kenz ENZYME n addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[7]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[7]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[7]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[7]/MAPK*/MAPK* /kinetics/chain/kinetics[7]/PLA2/PLA2* MM_PRD pA addmsg /kinetics/chain/kinetics[6]/PLA2/PLA2*/diff /kinetics/chain/kinetics[7]/PLA2/PLA2* REAC B A addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2*/diff /kinetics/chain/kinetics[7]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2* /kinetics/chain/kinetics[7]/PLA2/PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2* /kinetics/chain/kinetics[7]/PLA2/PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2* /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ca /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[7]/PLA2/dephosphorylate-PLA2* PRODUCT n addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2* /kinetics/chain/kinetics[7]/PLA2/dephosphorylate-PLA2* SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[7]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[7]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[7]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[7]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[7]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[7]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[7]/Ras-act-unphosph-raf /kinetics/chain/kinetics[7]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[7]/Ras-act-craf /kinetics/chain/kinetics[7]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[7]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[7]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[7]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[7]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[7]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[7]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[7]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[7]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[7]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[7]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[7]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK/diff /kinetics/chain/kinetics[7]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK/diff /kinetics/chain/kinetics[7]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK /kinetics/chain/kinetics[7]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK /kinetics/chain/kinetics[7]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[7]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[7]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[7]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[7]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[7]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[7]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[7]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[7]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[7]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK* /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK* /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[7]/Ras-act-unphosph-raf /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[7]/Ras-act-craf /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1* /kinetics/chain/kinetics[7]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[7]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ras/GTP-Ras /kinetics/chain/kinetics[7]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF /kinetics/chain/kinetics[7]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ras/GEF* /kinetics/chain/kinetics[7]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/dephosph-GEF /kinetics/chain/kinetics[7]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[7]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[7]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[7]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[7]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[7]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[6]/Ras/inact-GEF/diff /kinetics/chain/kinetics[7]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF/diff /kinetics/chain/kinetics[7]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF /kinetics/chain/kinetics[7]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[7]/Ras/GDP-Ras /kinetics/chain/kinetics[7]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF /kinetics/chain/kinetics[7]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF /kinetics/chain/kinetics[7]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ras/dephosph-GEF /kinetics/chain/kinetics[7]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[7]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[7]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[7]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[6]/Ras/GEF*/diff /kinetics/chain/kinetics[7]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[7]/Ras/GEF*/diff /kinetics/chain/kinetics[7]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/GEF* /kinetics/chain/kinetics[7]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[7]/Ras/GDP-Ras /kinetics/chain/kinetics[7]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/GEF* /kinetics/chain/kinetics[7]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/GEF* /kinetics/chain/kinetics[7]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ras-act-craf /kinetics/chain/kinetics[7]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[7]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[7]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[7]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[7]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[7]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[7]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[7]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[7]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[7]/Ras-act-unphosph-raf /kinetics/chain/kinetics[7]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[7]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[7]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[7]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[7]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[7]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[7]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[7]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[7]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[7]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[7]/Ras/GTP-Ras /kinetics/chain/kinetics[7]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/GDP-Ras /kinetics/chain/kinetics[7]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ras/GAP* /kinetics/chain/kinetics[7]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/GAP /kinetics/chain/kinetics[7]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ras/dephosph-GAP /kinetics/chain/kinetics[7]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[7]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[7]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[6]/Ras/GAP*/diff /kinetics/chain/kinetics[7]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[7]/Ras/GAP*/diff /kinetics/chain/kinetics[7]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/GAP* /kinetics/chain/kinetics[7]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/GAP* /kinetics/chain/kinetics[7]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ras/dephosph-GAP /kinetics/chain/kinetics[7]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[7]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[7]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[7]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[7]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[6]/Ras/GAP/diff /kinetics/chain/kinetics[7]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[7]/Ras/GAP/diff /kinetics/chain/kinetics[7]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/GTP-Ras /kinetics/chain/kinetics[7]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/GAP /kinetics/chain/kinetics[7]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[7]/Ras/GAP /kinetics/chain/kinetics[7]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/GAP /kinetics/chain/kinetics[7]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF /kinetics/chain/kinetics[7]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/CaM-GEF /kinetics/chain/kinetics[7]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 /kinetics/chain/kinetics[7]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[7]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[7]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[7]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[6]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[7]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[7]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[7]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[7]/Ras/GDP-Ras /kinetics/chain/kinetics[7]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ras/CaM-GEF /kinetics/chain/kinetics[7]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[7]/Ras/CaM-GEF /kinetics/chain/kinetics[7]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/CaM-GEF /kinetics/chain/kinetics[7]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[7]/Ca REAC A B addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[7]/Ca REAC A B addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[7]/Ca REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[7]/Ca REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[7]/Ca REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[7]/Ca REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[7]/Ca REAC A B addmsg /kinetics/chain/kinetics[7]/Ca_diff /kinetics/chain/kinetics[7]/Ca REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[7]/DAG REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG /kinetics/chain/kinetics[7]/DAG REAC A B addmsg /kinetics/chain/kinetics[7]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[7]/DAG REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[7]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[7]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[7]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[7]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[7]/PKC/PKC-basal* /kinetics/chain/kinetics[7]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[7]/PKC/PKC-AA* /kinetics/chain/kinetics[7]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[7]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[7]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[7]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[7]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[7]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[7]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[7]/PKC-active/phosph-AC2 /kinetics/chain/kinetics[7]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1 /kinetics/chain/kinetics[7]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC-active /kinetics/chain/kinetics[7]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[7]/Ras/GAP /kinetics/chain/kinetics[7]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC-active /kinetics/chain/kinetics[7]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF /kinetics/chain/kinetics[7]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PKC-active /kinetics/chain/kinetics[7]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[7]/PKC-active /kinetics/chain/kinetics[7]/PKC-active/phosph-AC2 ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[7]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MAPK*/MAPK* /kinetics/chain/kinetics[7]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[7]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[7]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[7]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[7]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[6]/MAPK*/diff /kinetics/chain/kinetics[7]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[7]/MAPK*/diff /kinetics/chain/kinetics[7]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[7]/MAPK*/MAPK* SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK* /kinetics/chain/kinetics[7]/MAPK*/MAPK* ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1* /kinetics/chain/kinetics[7]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK* /kinetics/chain/kinetics[7]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK* /kinetics/chain/kinetics[7]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK* /kinetics/chain/kinetics[7]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[7]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[7]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[7]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[6]/MKP-1/diff /kinetics/chain/kinetics[7]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[7]/MKP-1/diff /kinetics/chain/kinetics[7]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr /kinetics/chain/kinetics[7]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MKP-1 /kinetics/chain/kinetics[7]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK* /kinetics/chain/kinetics[7]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MKP-1 /kinetics/chain/kinetics[7]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[7]/MKP-1 /kinetics/chain/kinetics[7]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MKP-1 /kinetics/chain/kinetics[7]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[7]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[7]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[7]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[7]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[6]/PPhosphatase2A/diff /kinetics/chain/kinetics[7]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/diff /kinetics/chain/kinetics[7]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1* /kinetics/chain/kinetics[7]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A /kinetics/chain/kinetics[7]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK* /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1** /kinetics/chain/kinetics[7]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A /kinetics/chain/kinetics[7]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A /kinetics/chain/kinetics[7]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A /kinetics/chain/kinetics[7]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[7]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM/diff /kinetics/chain/kinetics[7]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[7]/CaM/CaM/diff /kinetics/chain/kinetics[7]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM /kinetics/chain/kinetics[7]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM /kinetics/chain/kinetics[7]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ca /kinetics/chain/kinetics[7]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ca /kinetics/chain/kinetics[7]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM /kinetics/chain/kinetics[7]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[7]/CaM/CaM-TR2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ca /kinetics/chain/kinetics[7]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca3 /kinetics/chain/kinetics[7]/CaM/CaM-TR2-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[7]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca3 /kinetics/chain/kinetics[7]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 /kinetics/chain/kinetics[7]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[7]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[7]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca3 /kinetics/chain/kinetics[7]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca3 /kinetics/chain/kinetics[7]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[7]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[7]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[7]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[6]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[7]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[7]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[7]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[7]/CaM/CaM-TR2-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[7]/CaM/CaM-TR2-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[6]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca4 /kinetics/chain/kinetics[7]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca4 /kinetics/chain/kinetics[7]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/MAPK/craf-1 /kinetics/chain/kinetics[7]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[7]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ras/GTP-Ras /kinetics/chain/kinetics[7]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[7]/Ca_diff /kinetics/chain/kinetics[7]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[7]/Ca /kinetics/chain/kinetics[7]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[7]/Ca_input /kinetics/chain/kinetics[7]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[8]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[8]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[8]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[8]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[8]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[8]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca /kinetics/chain/kinetics[8]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca /kinetics/chain/kinetics[8]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ca /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca /kinetics/chain/kinetics[8]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[8]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[8]/DAG /kinetics/chain/kinetics[8]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca /kinetics/chain/kinetics[8]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[8]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[8]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[8]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca-AA PRODUCT n addmsg /kinetics/chain/kinetics[8]/AA /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[8]/PKC/PKC-act-by-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[8]/PKC/PKC-act-by-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[8]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[8]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[8]/PKC/PKC-DAG-AA* REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[8]/PKC/PKC-DAG-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[8]/PKC/PKC-DAG-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[8]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[8]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[8]/PKC/PKC-Ca-AA* REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[8]/PKC/PKC-Ca-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[8]/PKC/PKC-Ca-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-basal-act /kinetics/chain/kinetics[8]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[8]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[8]/PKC/PKC-basal* REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-basal* /kinetics/chain/kinetics[8]/PKC/PKC-basal*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-basal* /kinetics/chain/kinetics[8]/PKC/PKC-basal*/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-basal* /kinetics/chain/kinetics[8]/PKC/PKC-basal-act PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic /kinetics/chain/kinetics[8]/PKC/PKC-basal-act SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[8]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[8]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[8]/PKC/PKC-AA* REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-AA* /kinetics/chain/kinetics[8]/PKC/PKC-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-AA* /kinetics/chain/kinetics[8]/PKC/PKC-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-AA* /kinetics/chain/kinetics[8]/PKC/PKC-act-by-AA PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic /kinetics/chain/kinetics[8]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/AA /kinetics/chain/kinetics[8]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/DAG /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG /kinetics/chain/kinetics[8]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[8]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[8]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[8]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG /kinetics/chain/kinetics[8]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG /kinetics/chain/kinetics[8]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[8]/AA /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[8]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[8]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[7]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[8]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[8]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[8]/PKC/PKC-DAG-AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[8]/PKC/PKC-DAG-AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-basal-act /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[8]/AA REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[8]/AA REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[8]/AA REAC A B addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[8]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[8]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[8]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[8]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[8]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[8]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[8]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[8]/PLA2/Degrade-AA /kinetics/chain/kinetics[8]/AA REAC A B addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[8]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[7]/AA/diff /kinetics/chain/kinetics[8]/AA REAC B A addmsg /kinetics/chain/kinetics[8]/AA/diff /kinetics/chain/kinetics[8]/AA REAC A B addmsg /kinetics/chain/kinetics[8]/AA /kinetics/chain/kinetics[8]/AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/AA /kinetics/chain/kinetics[8]/AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[8]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[8]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[8]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[8]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[8]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[8]/MAPK*/MAPK* /kinetics/chain/kinetics[8]/PLA2/PLA2-cytosolic REAC sA B addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[8]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[8]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[8]/PLA2/PLA2-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[8]/PLA2/PLA2-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ca /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca* REAC eA B addmsg /kinetics/chain/kinetics[8]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[8]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca*/kenz ENZYME n addmsg /kinetics/chain/kinetics[8]/PLA2/APC /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca*/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[8]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[8]/PLA2/PIP2-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[8]/temp-PIP2 /kinetics/chain/kinetics[8]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[8]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[8]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[8]/PLA2/PIP2-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[7]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[8]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[8]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[8]/PLA2/PIP2-PLA2* REAC A B addmsg /kinetics/chain/kinetics[8]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[8]/PLA2/PIP2-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[8]/PLA2/APC /kinetics/chain/kinetics[8]/PLA2/PIP2-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[8]/PLA2/PIP2-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[8]/PLA2/PIP2-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[8]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[8]/PLA2/PIP2-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[8]/temp-PIP2 /kinetics/chain/kinetics[8]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[8]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[8]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[8]/PLA2/PIP2-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[7]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[8]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[8]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[8]/PLA2/PIP2-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[8]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[8]/PLA2/PIP2-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[8]/PLA2/APC /kinetics/chain/kinetics[8]/PLA2/PIP2-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[8]/PLA2/PIP2-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[8]/PLA2/PIP2-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[8]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[8]/PLA2/DAG-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[8]/DAG /kinetics/chain/kinetics[8]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[8]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[8]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[8]/PLA2/DAG-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[7]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[8]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[8]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[8]/PLA2/DAG-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[8]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[8]/PLA2/DAG-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[8]/PLA2/APC /kinetics/chain/kinetics[8]/PLA2/DAG-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[8]/PLA2/DAG-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[8]/PLA2/DAG-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[8]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[8]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[8]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[8]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[8]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[8]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[8]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[8]/PLA2/Degrade-AA /kinetics/chain/kinetics[8]/PLA2/APC REAC B A addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[8]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[8]/AA /kinetics/chain/kinetics[8]/PLA2/Degrade-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PLA2/APC /kinetics/chain/kinetics[8]/PLA2/Degrade-AA PRODUCT n addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca REAC eA B addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca REAC A B addmsg /kinetics/chain/kinetics[8]/PLA2/APC /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca/kenz ENZYME n addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[8]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[8]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[8]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[8]/MAPK*/MAPK* /kinetics/chain/kinetics[8]/PLA2/PLA2* MM_PRD pA addmsg /kinetics/chain/kinetics[7]/PLA2/PLA2*/diff /kinetics/chain/kinetics[8]/PLA2/PLA2* REAC B A addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2*/diff /kinetics/chain/kinetics[8]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2* /kinetics/chain/kinetics[8]/PLA2/PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2* /kinetics/chain/kinetics[8]/PLA2/PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2* /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ca /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[8]/PLA2/dephosphorylate-PLA2* PRODUCT n addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2* /kinetics/chain/kinetics[8]/PLA2/dephosphorylate-PLA2* SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[8]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[8]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[8]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[8]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[8]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[8]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[8]/Ras-act-unphosph-raf /kinetics/chain/kinetics[8]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[8]/Ras-act-craf /kinetics/chain/kinetics[8]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[8]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[8]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[8]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[8]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[8]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[8]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[8]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[8]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[8]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[8]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[8]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK/diff /kinetics/chain/kinetics[8]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK/diff /kinetics/chain/kinetics[8]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK /kinetics/chain/kinetics[8]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK /kinetics/chain/kinetics[8]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[8]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[8]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[8]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[8]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[8]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[8]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[8]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[8]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[8]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK* /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK* /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[8]/Ras-act-unphosph-raf /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[8]/Ras-act-craf /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1* /kinetics/chain/kinetics[8]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[8]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ras/GTP-Ras /kinetics/chain/kinetics[8]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF /kinetics/chain/kinetics[8]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ras/GEF* /kinetics/chain/kinetics[8]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/dephosph-GEF /kinetics/chain/kinetics[8]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[8]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[8]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[8]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[8]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[8]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[7]/Ras/inact-GEF/diff /kinetics/chain/kinetics[8]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF/diff /kinetics/chain/kinetics[8]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF /kinetics/chain/kinetics[8]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[8]/Ras/GDP-Ras /kinetics/chain/kinetics[8]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF /kinetics/chain/kinetics[8]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF /kinetics/chain/kinetics[8]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ras/dephosph-GEF /kinetics/chain/kinetics[8]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[8]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[8]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[8]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[7]/Ras/GEF*/diff /kinetics/chain/kinetics[8]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[8]/Ras/GEF*/diff /kinetics/chain/kinetics[8]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/GEF* /kinetics/chain/kinetics[8]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[8]/Ras/GDP-Ras /kinetics/chain/kinetics[8]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/GEF* /kinetics/chain/kinetics[8]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/GEF* /kinetics/chain/kinetics[8]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ras-act-craf /kinetics/chain/kinetics[8]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[8]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[8]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[8]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[8]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[8]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[8]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[8]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[8]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[8]/Ras-act-unphosph-raf /kinetics/chain/kinetics[8]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[8]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[8]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[8]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[8]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[8]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[8]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[8]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[8]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[8]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[8]/Ras/GTP-Ras /kinetics/chain/kinetics[8]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/GDP-Ras /kinetics/chain/kinetics[8]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ras/GAP* /kinetics/chain/kinetics[8]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/GAP /kinetics/chain/kinetics[8]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ras/dephosph-GAP /kinetics/chain/kinetics[8]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[8]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[8]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[7]/Ras/GAP*/diff /kinetics/chain/kinetics[8]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[8]/Ras/GAP*/diff /kinetics/chain/kinetics[8]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/GAP* /kinetics/chain/kinetics[8]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/GAP* /kinetics/chain/kinetics[8]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ras/dephosph-GAP /kinetics/chain/kinetics[8]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[8]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[8]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[8]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[8]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[7]/Ras/GAP/diff /kinetics/chain/kinetics[8]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[8]/Ras/GAP/diff /kinetics/chain/kinetics[8]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/GTP-Ras /kinetics/chain/kinetics[8]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/GAP /kinetics/chain/kinetics[8]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[8]/Ras/GAP /kinetics/chain/kinetics[8]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/GAP /kinetics/chain/kinetics[8]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF /kinetics/chain/kinetics[8]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/CaM-GEF /kinetics/chain/kinetics[8]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca4 /kinetics/chain/kinetics[8]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[8]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[8]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[8]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[7]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[8]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[8]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[8]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[8]/Ras/GDP-Ras /kinetics/chain/kinetics[8]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ras/CaM-GEF /kinetics/chain/kinetics[8]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[8]/Ras/CaM-GEF /kinetics/chain/kinetics[8]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/CaM-GEF /kinetics/chain/kinetics[8]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[8]/Ca REAC A B addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[8]/Ca REAC A B addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[8]/Ca REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[8]/Ca REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[8]/Ca REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[8]/Ca REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[8]/Ca REAC A B addmsg /kinetics/chain/kinetics[8]/Ca_diff /kinetics/chain/kinetics[8]/Ca REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[8]/DAG REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG /kinetics/chain/kinetics[8]/DAG REAC A B addmsg /kinetics/chain/kinetics[8]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[8]/DAG REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[8]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[8]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[8]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[8]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[8]/PKC/PKC-basal* /kinetics/chain/kinetics[8]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[8]/PKC/PKC-AA* /kinetics/chain/kinetics[8]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[8]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[8]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[8]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[8]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[8]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[8]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[8]/PKC-active/phosph-AC2 /kinetics/chain/kinetics[8]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1 /kinetics/chain/kinetics[8]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC-active /kinetics/chain/kinetics[8]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[8]/Ras/GAP /kinetics/chain/kinetics[8]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC-active /kinetics/chain/kinetics[8]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF /kinetics/chain/kinetics[8]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PKC-active /kinetics/chain/kinetics[8]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[8]/PKC-active /kinetics/chain/kinetics[8]/PKC-active/phosph-AC2 ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[8]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MAPK*/MAPK* /kinetics/chain/kinetics[8]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[8]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[8]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[8]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[8]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[7]/MAPK*/diff /kinetics/chain/kinetics[8]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[8]/MAPK*/diff /kinetics/chain/kinetics[8]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[8]/MAPK*/MAPK* SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK* /kinetics/chain/kinetics[8]/MAPK*/MAPK* ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1* /kinetics/chain/kinetics[8]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK* /kinetics/chain/kinetics[8]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK* /kinetics/chain/kinetics[8]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK* /kinetics/chain/kinetics[8]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[8]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[8]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[8]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[7]/MKP-1/diff /kinetics/chain/kinetics[8]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[8]/MKP-1/diff /kinetics/chain/kinetics[8]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr /kinetics/chain/kinetics[8]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MKP-1 /kinetics/chain/kinetics[8]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK* /kinetics/chain/kinetics[8]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MKP-1 /kinetics/chain/kinetics[8]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[8]/MKP-1 /kinetics/chain/kinetics[8]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MKP-1 /kinetics/chain/kinetics[8]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[8]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[8]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[8]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[8]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[7]/PPhosphatase2A/diff /kinetics/chain/kinetics[8]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/diff /kinetics/chain/kinetics[8]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1* /kinetics/chain/kinetics[8]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A /kinetics/chain/kinetics[8]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK* /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1** /kinetics/chain/kinetics[8]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A /kinetics/chain/kinetics[8]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A /kinetics/chain/kinetics[8]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A /kinetics/chain/kinetics[8]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[8]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM/diff /kinetics/chain/kinetics[8]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[8]/CaM/CaM/diff /kinetics/chain/kinetics[8]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM /kinetics/chain/kinetics[8]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM /kinetics/chain/kinetics[8]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ca /kinetics/chain/kinetics[8]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ca /kinetics/chain/kinetics[8]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM /kinetics/chain/kinetics[8]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[8]/CaM/CaM-TR2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ca /kinetics/chain/kinetics[8]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca3 /kinetics/chain/kinetics[8]/CaM/CaM-TR2-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[8]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca3 /kinetics/chain/kinetics[8]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca4 /kinetics/chain/kinetics[8]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[8]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[8]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca3 /kinetics/chain/kinetics[8]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca3 /kinetics/chain/kinetics[8]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[8]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[8]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[8]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[7]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[8]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[8]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[8]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[8]/CaM/CaM-TR2-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[8]/CaM/CaM-TR2-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[8]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[8]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[7]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[8]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[8]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca4 /kinetics/chain/kinetics[8]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca4 /kinetics/chain/kinetics[8]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/MAPK/craf-1 /kinetics/chain/kinetics[8]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[8]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ras/GTP-Ras /kinetics/chain/kinetics[8]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[8]/Ca_diff /kinetics/chain/kinetics[8]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[8]/Ca /kinetics/chain/kinetics[8]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[8]/Ca_input /kinetics/chain/kinetics[8]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[9]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[9]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[9]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[9]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[9]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[9]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca /kinetics/chain/kinetics[9]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca /kinetics/chain/kinetics[9]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ca /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca /kinetics/chain/kinetics[9]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[9]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[9]/DAG /kinetics/chain/kinetics[9]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca /kinetics/chain/kinetics[9]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[9]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[9]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[9]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca-AA PRODUCT n addmsg /kinetics/chain/kinetics[9]/AA /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[9]/PKC/PKC-act-by-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[9]/PKC/PKC-act-by-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[9]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[9]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[9]/PKC/PKC-DAG-AA* REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[9]/PKC/PKC-DAG-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[9]/PKC/PKC-DAG-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[9]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[9]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[9]/PKC/PKC-Ca-AA* REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[9]/PKC/PKC-Ca-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[9]/PKC/PKC-Ca-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-basal-act /kinetics/chain/kinetics[9]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[9]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[9]/PKC/PKC-basal* REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-basal* /kinetics/chain/kinetics[9]/PKC/PKC-basal*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-basal* /kinetics/chain/kinetics[9]/PKC/PKC-basal*/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-basal* /kinetics/chain/kinetics[9]/PKC/PKC-basal-act PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic /kinetics/chain/kinetics[9]/PKC/PKC-basal-act SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[9]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[9]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[9]/PKC/PKC-AA* REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-AA* /kinetics/chain/kinetics[9]/PKC/PKC-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-AA* /kinetics/chain/kinetics[9]/PKC/PKC-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-AA* /kinetics/chain/kinetics[9]/PKC/PKC-act-by-AA PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic /kinetics/chain/kinetics[9]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/AA /kinetics/chain/kinetics[9]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/DAG /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG /kinetics/chain/kinetics[9]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[9]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[9]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[9]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG /kinetics/chain/kinetics[9]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG /kinetics/chain/kinetics[9]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[9]/AA /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[9]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[9]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[8]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[9]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[9]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[9]/PKC/PKC-DAG-AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[9]/PKC/PKC-DAG-AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-basal-act /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[9]/AA REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[9]/AA REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[9]/AA REAC A B addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[9]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[9]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[9]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[9]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[9]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[9]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[9]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[9]/PLA2/Degrade-AA /kinetics/chain/kinetics[9]/AA REAC A B addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[9]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[8]/AA/diff /kinetics/chain/kinetics[9]/AA REAC B A addmsg /kinetics/chain/kinetics[9]/AA/diff /kinetics/chain/kinetics[9]/AA REAC A B addmsg /kinetics/chain/kinetics[9]/AA /kinetics/chain/kinetics[9]/AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/AA /kinetics/chain/kinetics[9]/AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[9]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[9]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[9]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[9]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[9]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[9]/MAPK*/MAPK* /kinetics/chain/kinetics[9]/PLA2/PLA2-cytosolic REAC sA B addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[9]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[9]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[9]/PLA2/PLA2-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[9]/PLA2/PLA2-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ca /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca* REAC eA B addmsg /kinetics/chain/kinetics[9]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[9]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca*/kenz ENZYME n addmsg /kinetics/chain/kinetics[9]/PLA2/APC /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca*/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[9]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[9]/PLA2/PIP2-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[9]/temp-PIP2 /kinetics/chain/kinetics[9]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[9]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[9]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[9]/PLA2/PIP2-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[8]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[9]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[9]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[9]/PLA2/PIP2-PLA2* REAC A B addmsg /kinetics/chain/kinetics[9]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[9]/PLA2/PIP2-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[9]/PLA2/APC /kinetics/chain/kinetics[9]/PLA2/PIP2-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[9]/PLA2/PIP2-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[9]/PLA2/PIP2-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[9]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[9]/PLA2/PIP2-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[9]/temp-PIP2 /kinetics/chain/kinetics[9]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[9]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[9]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[9]/PLA2/PIP2-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[8]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[9]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[9]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[9]/PLA2/PIP2-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[9]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[9]/PLA2/PIP2-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[9]/PLA2/APC /kinetics/chain/kinetics[9]/PLA2/PIP2-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[9]/PLA2/PIP2-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[9]/PLA2/PIP2-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[9]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[9]/PLA2/DAG-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[9]/DAG /kinetics/chain/kinetics[9]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[9]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[9]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[9]/PLA2/DAG-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[8]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[9]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[9]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[9]/PLA2/DAG-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[9]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[9]/PLA2/DAG-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[9]/PLA2/APC /kinetics/chain/kinetics[9]/PLA2/DAG-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[9]/PLA2/DAG-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[9]/PLA2/DAG-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[9]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[9]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[9]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[9]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[9]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[9]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[9]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[9]/PLA2/Degrade-AA /kinetics/chain/kinetics[9]/PLA2/APC REAC B A addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[9]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[9]/AA /kinetics/chain/kinetics[9]/PLA2/Degrade-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PLA2/APC /kinetics/chain/kinetics[9]/PLA2/Degrade-AA PRODUCT n addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca REAC eA B addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca REAC A B addmsg /kinetics/chain/kinetics[9]/PLA2/APC /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca/kenz ENZYME n addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[9]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[9]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[9]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[9]/MAPK*/MAPK* /kinetics/chain/kinetics[9]/PLA2/PLA2* MM_PRD pA addmsg /kinetics/chain/kinetics[8]/PLA2/PLA2*/diff /kinetics/chain/kinetics[9]/PLA2/PLA2* REAC B A addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2*/diff /kinetics/chain/kinetics[9]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2* /kinetics/chain/kinetics[9]/PLA2/PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2* /kinetics/chain/kinetics[9]/PLA2/PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2* /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ca /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[9]/PLA2/dephosphorylate-PLA2* PRODUCT n addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2* /kinetics/chain/kinetics[9]/PLA2/dephosphorylate-PLA2* SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[9]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[9]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[9]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[9]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[9]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[9]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[9]/Ras-act-unphosph-raf /kinetics/chain/kinetics[9]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[9]/Ras-act-craf /kinetics/chain/kinetics[9]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[9]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[9]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[9]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[9]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[9]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[9]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[9]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[9]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[9]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[9]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[9]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK/diff /kinetics/chain/kinetics[9]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK/diff /kinetics/chain/kinetics[9]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK /kinetics/chain/kinetics[9]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK /kinetics/chain/kinetics[9]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[9]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[9]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[9]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[9]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[9]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[9]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[9]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[9]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[9]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK* /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK* /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[9]/Ras-act-unphosph-raf /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[9]/Ras-act-craf /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1* /kinetics/chain/kinetics[9]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[9]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ras/GTP-Ras /kinetics/chain/kinetics[9]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF /kinetics/chain/kinetics[9]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ras/GEF* /kinetics/chain/kinetics[9]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/dephosph-GEF /kinetics/chain/kinetics[9]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[9]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[9]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[9]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[9]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[9]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[8]/Ras/inact-GEF/diff /kinetics/chain/kinetics[9]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF/diff /kinetics/chain/kinetics[9]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF /kinetics/chain/kinetics[9]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[9]/Ras/GDP-Ras /kinetics/chain/kinetics[9]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF /kinetics/chain/kinetics[9]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF /kinetics/chain/kinetics[9]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ras/dephosph-GEF /kinetics/chain/kinetics[9]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[9]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[9]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[9]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[8]/Ras/GEF*/diff /kinetics/chain/kinetics[9]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[9]/Ras/GEF*/diff /kinetics/chain/kinetics[9]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/GEF* /kinetics/chain/kinetics[9]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[9]/Ras/GDP-Ras /kinetics/chain/kinetics[9]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/GEF* /kinetics/chain/kinetics[9]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/GEF* /kinetics/chain/kinetics[9]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ras-act-craf /kinetics/chain/kinetics[9]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[9]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[9]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[9]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[9]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[9]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[9]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[9]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[9]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[9]/Ras-act-unphosph-raf /kinetics/chain/kinetics[9]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[9]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[9]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[9]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[9]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[9]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[9]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[9]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[9]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[9]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[9]/Ras/GTP-Ras /kinetics/chain/kinetics[9]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/GDP-Ras /kinetics/chain/kinetics[9]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ras/GAP* /kinetics/chain/kinetics[9]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/GAP /kinetics/chain/kinetics[9]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ras/dephosph-GAP /kinetics/chain/kinetics[9]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[9]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[9]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[8]/Ras/GAP*/diff /kinetics/chain/kinetics[9]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[9]/Ras/GAP*/diff /kinetics/chain/kinetics[9]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/GAP* /kinetics/chain/kinetics[9]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/GAP* /kinetics/chain/kinetics[9]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ras/dephosph-GAP /kinetics/chain/kinetics[9]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[9]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[9]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[9]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[9]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[8]/Ras/GAP/diff /kinetics/chain/kinetics[9]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[9]/Ras/GAP/diff /kinetics/chain/kinetics[9]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/GTP-Ras /kinetics/chain/kinetics[9]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/GAP /kinetics/chain/kinetics[9]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[9]/Ras/GAP /kinetics/chain/kinetics[9]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/GAP /kinetics/chain/kinetics[9]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF /kinetics/chain/kinetics[9]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/CaM-GEF /kinetics/chain/kinetics[9]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca4 /kinetics/chain/kinetics[9]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[9]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[9]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[9]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[8]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[9]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[9]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[9]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[9]/Ras/GDP-Ras /kinetics/chain/kinetics[9]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ras/CaM-GEF /kinetics/chain/kinetics[9]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[9]/Ras/CaM-GEF /kinetics/chain/kinetics[9]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/CaM-GEF /kinetics/chain/kinetics[9]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[9]/Ca REAC A B addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[9]/Ca REAC A B addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[9]/Ca REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[9]/Ca REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[9]/Ca REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[9]/Ca REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[9]/Ca REAC A B addmsg /kinetics/chain/kinetics[9]/Ca_diff /kinetics/chain/kinetics[9]/Ca REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[9]/DAG REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG /kinetics/chain/kinetics[9]/DAG REAC A B addmsg /kinetics/chain/kinetics[9]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[9]/DAG REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[9]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[9]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[9]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[9]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[9]/PKC/PKC-basal* /kinetics/chain/kinetics[9]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[9]/PKC/PKC-AA* /kinetics/chain/kinetics[9]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[9]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[9]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[9]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[9]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[9]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[9]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[9]/PKC-active/phosph-AC2 /kinetics/chain/kinetics[9]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1 /kinetics/chain/kinetics[9]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC-active /kinetics/chain/kinetics[9]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[9]/Ras/GAP /kinetics/chain/kinetics[9]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC-active /kinetics/chain/kinetics[9]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF /kinetics/chain/kinetics[9]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PKC-active /kinetics/chain/kinetics[9]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[9]/PKC-active /kinetics/chain/kinetics[9]/PKC-active/phosph-AC2 ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[9]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MAPK*/MAPK* /kinetics/chain/kinetics[9]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[9]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[9]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[9]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[9]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[8]/MAPK*/diff /kinetics/chain/kinetics[9]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[9]/MAPK*/diff /kinetics/chain/kinetics[9]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[9]/MAPK*/MAPK* SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK* /kinetics/chain/kinetics[9]/MAPK*/MAPK* ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1* /kinetics/chain/kinetics[9]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK* /kinetics/chain/kinetics[9]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK* /kinetics/chain/kinetics[9]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK* /kinetics/chain/kinetics[9]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[9]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[9]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[9]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[8]/MKP-1/diff /kinetics/chain/kinetics[9]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[9]/MKP-1/diff /kinetics/chain/kinetics[9]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr /kinetics/chain/kinetics[9]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MKP-1 /kinetics/chain/kinetics[9]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK* /kinetics/chain/kinetics[9]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MKP-1 /kinetics/chain/kinetics[9]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[9]/MKP-1 /kinetics/chain/kinetics[9]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MKP-1 /kinetics/chain/kinetics[9]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[9]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[9]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[9]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[9]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[8]/PPhosphatase2A/diff /kinetics/chain/kinetics[9]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/diff /kinetics/chain/kinetics[9]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1* /kinetics/chain/kinetics[9]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A /kinetics/chain/kinetics[9]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK* /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1** /kinetics/chain/kinetics[9]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A /kinetics/chain/kinetics[9]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A /kinetics/chain/kinetics[9]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A /kinetics/chain/kinetics[9]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[9]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM/diff /kinetics/chain/kinetics[9]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[9]/CaM/CaM/diff /kinetics/chain/kinetics[9]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM /kinetics/chain/kinetics[9]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM /kinetics/chain/kinetics[9]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ca /kinetics/chain/kinetics[9]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ca /kinetics/chain/kinetics[9]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM /kinetics/chain/kinetics[9]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[9]/CaM/CaM-TR2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ca /kinetics/chain/kinetics[9]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca3 /kinetics/chain/kinetics[9]/CaM/CaM-TR2-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[9]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca3 /kinetics/chain/kinetics[9]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca4 /kinetics/chain/kinetics[9]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[9]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[9]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca3 /kinetics/chain/kinetics[9]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca3 /kinetics/chain/kinetics[9]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[9]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[9]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[9]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[8]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[9]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[9]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[9]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[9]/CaM/CaM-TR2-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[9]/CaM/CaM-TR2-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[9]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[9]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[8]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[9]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[9]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca4 /kinetics/chain/kinetics[9]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca4 /kinetics/chain/kinetics[9]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/MAPK/craf-1 /kinetics/chain/kinetics[9]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[9]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ras/GTP-Ras /kinetics/chain/kinetics[9]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[9]/Ca_diff /kinetics/chain/kinetics[9]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[9]/Ca /kinetics/chain/kinetics[9]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[9]/Ca_input /kinetics/chain/kinetics[9]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[10]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[10]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[10]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[10]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[10]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[10]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca /kinetics/chain/kinetics[10]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca /kinetics/chain/kinetics[10]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ca /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca /kinetics/chain/kinetics[10]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[10]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[10]/DAG /kinetics/chain/kinetics[10]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca /kinetics/chain/kinetics[10]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[10]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[10]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[10]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca-AA PRODUCT n addmsg /kinetics/chain/kinetics[10]/AA /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[10]/PKC/PKC-act-by-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[10]/PKC/PKC-act-by-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[10]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[10]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[10]/PKC/PKC-DAG-AA* REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[10]/PKC/PKC-DAG-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[10]/PKC/PKC-DAG-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[10]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[10]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[10]/PKC/PKC-Ca-AA* REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[10]/PKC/PKC-Ca-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[10]/PKC/PKC-Ca-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-basal-act /kinetics/chain/kinetics[10]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[10]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[10]/PKC/PKC-basal* REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-basal* /kinetics/chain/kinetics[10]/PKC/PKC-basal*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-basal* /kinetics/chain/kinetics[10]/PKC/PKC-basal*/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-basal* /kinetics/chain/kinetics[10]/PKC/PKC-basal-act PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic /kinetics/chain/kinetics[10]/PKC/PKC-basal-act SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[10]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[10]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[10]/PKC/PKC-AA* REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-AA* /kinetics/chain/kinetics[10]/PKC/PKC-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-AA* /kinetics/chain/kinetics[10]/PKC/PKC-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-AA* /kinetics/chain/kinetics[10]/PKC/PKC-act-by-AA PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic /kinetics/chain/kinetics[10]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/AA /kinetics/chain/kinetics[10]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/DAG /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG /kinetics/chain/kinetics[10]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[10]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[10]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[10]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG /kinetics/chain/kinetics[10]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG /kinetics/chain/kinetics[10]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[10]/AA /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[10]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[10]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[9]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[10]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[10]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[10]/PKC/PKC-DAG-AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[10]/PKC/PKC-DAG-AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-basal-act /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[10]/AA REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[10]/AA REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[10]/AA REAC A B addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[10]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[10]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[10]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[10]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[10]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[10]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[10]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[10]/PLA2/Degrade-AA /kinetics/chain/kinetics[10]/AA REAC A B addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[10]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[9]/AA/diff /kinetics/chain/kinetics[10]/AA REAC B A addmsg /kinetics/chain/kinetics[10]/AA/diff /kinetics/chain/kinetics[10]/AA REAC A B addmsg /kinetics/chain/kinetics[10]/AA /kinetics/chain/kinetics[10]/AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/AA /kinetics/chain/kinetics[10]/AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[10]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[10]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[10]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[10]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[10]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[10]/MAPK*/MAPK* /kinetics/chain/kinetics[10]/PLA2/PLA2-cytosolic REAC sA B addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[10]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[10]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[10]/PLA2/PLA2-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[10]/PLA2/PLA2-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ca /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca* REAC eA B addmsg /kinetics/chain/kinetics[10]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[10]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca*/kenz ENZYME n addmsg /kinetics/chain/kinetics[10]/PLA2/APC /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca*/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[10]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[10]/PLA2/PIP2-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[10]/temp-PIP2 /kinetics/chain/kinetics[10]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[10]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[10]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[10]/PLA2/PIP2-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[9]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[10]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[10]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[10]/PLA2/PIP2-PLA2* REAC A B addmsg /kinetics/chain/kinetics[10]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[10]/PLA2/PIP2-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[10]/PLA2/APC /kinetics/chain/kinetics[10]/PLA2/PIP2-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[10]/PLA2/PIP2-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[10]/PLA2/PIP2-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[10]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[10]/PLA2/PIP2-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[10]/temp-PIP2 /kinetics/chain/kinetics[10]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[10]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[10]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[10]/PLA2/PIP2-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[9]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[10]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[10]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[10]/PLA2/PIP2-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[10]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[10]/PLA2/PIP2-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[10]/PLA2/APC /kinetics/chain/kinetics[10]/PLA2/PIP2-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[10]/PLA2/PIP2-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[10]/PLA2/PIP2-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[10]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[10]/PLA2/DAG-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[10]/DAG /kinetics/chain/kinetics[10]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[10]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[10]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[10]/PLA2/DAG-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[9]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[10]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[10]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[10]/PLA2/DAG-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[10]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[10]/PLA2/DAG-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[10]/PLA2/APC /kinetics/chain/kinetics[10]/PLA2/DAG-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[10]/PLA2/DAG-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[10]/PLA2/DAG-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[10]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[10]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[10]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[10]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[10]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[10]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[10]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[10]/PLA2/Degrade-AA /kinetics/chain/kinetics[10]/PLA2/APC REAC B A addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[10]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[10]/AA /kinetics/chain/kinetics[10]/PLA2/Degrade-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PLA2/APC /kinetics/chain/kinetics[10]/PLA2/Degrade-AA PRODUCT n addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca REAC eA B addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca REAC A B addmsg /kinetics/chain/kinetics[10]/PLA2/APC /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca/kenz ENZYME n addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[10]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[10]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[10]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[10]/MAPK*/MAPK* /kinetics/chain/kinetics[10]/PLA2/PLA2* MM_PRD pA addmsg /kinetics/chain/kinetics[9]/PLA2/PLA2*/diff /kinetics/chain/kinetics[10]/PLA2/PLA2* REAC B A addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2*/diff /kinetics/chain/kinetics[10]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2* /kinetics/chain/kinetics[10]/PLA2/PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2* /kinetics/chain/kinetics[10]/PLA2/PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2* /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ca /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[10]/PLA2/dephosphorylate-PLA2* PRODUCT n addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2* /kinetics/chain/kinetics[10]/PLA2/dephosphorylate-PLA2* SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[10]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[10]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[10]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[10]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[10]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[10]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[10]/Ras-act-unphosph-raf /kinetics/chain/kinetics[10]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[10]/Ras-act-craf /kinetics/chain/kinetics[10]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[10]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[10]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[10]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[10]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[10]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[10]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[10]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[10]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[10]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[10]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[10]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK/diff /kinetics/chain/kinetics[10]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK/diff /kinetics/chain/kinetics[10]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK /kinetics/chain/kinetics[10]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK /kinetics/chain/kinetics[10]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[10]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[10]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[10]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[10]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[10]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[10]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[10]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[10]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[10]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK* /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK* /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[10]/Ras-act-unphosph-raf /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[10]/Ras-act-craf /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1* /kinetics/chain/kinetics[10]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[10]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ras/GTP-Ras /kinetics/chain/kinetics[10]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF /kinetics/chain/kinetics[10]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ras/GEF* /kinetics/chain/kinetics[10]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/dephosph-GEF /kinetics/chain/kinetics[10]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[10]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[10]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[10]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[10]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[10]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[9]/Ras/inact-GEF/diff /kinetics/chain/kinetics[10]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF/diff /kinetics/chain/kinetics[10]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF /kinetics/chain/kinetics[10]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[10]/Ras/GDP-Ras /kinetics/chain/kinetics[10]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF /kinetics/chain/kinetics[10]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF /kinetics/chain/kinetics[10]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ras/dephosph-GEF /kinetics/chain/kinetics[10]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[10]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[10]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[10]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[9]/Ras/GEF*/diff /kinetics/chain/kinetics[10]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[10]/Ras/GEF*/diff /kinetics/chain/kinetics[10]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/GEF* /kinetics/chain/kinetics[10]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[10]/Ras/GDP-Ras /kinetics/chain/kinetics[10]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/GEF* /kinetics/chain/kinetics[10]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/GEF* /kinetics/chain/kinetics[10]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ras-act-craf /kinetics/chain/kinetics[10]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[10]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[10]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[10]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[10]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[10]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[10]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[10]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[10]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[10]/Ras-act-unphosph-raf /kinetics/chain/kinetics[10]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[10]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[10]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[10]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[10]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[10]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[10]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[10]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[10]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[10]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[10]/Ras/GTP-Ras /kinetics/chain/kinetics[10]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/GDP-Ras /kinetics/chain/kinetics[10]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ras/GAP* /kinetics/chain/kinetics[10]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/GAP /kinetics/chain/kinetics[10]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ras/dephosph-GAP /kinetics/chain/kinetics[10]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[10]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[10]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[9]/Ras/GAP*/diff /kinetics/chain/kinetics[10]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[10]/Ras/GAP*/diff /kinetics/chain/kinetics[10]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/GAP* /kinetics/chain/kinetics[10]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/GAP* /kinetics/chain/kinetics[10]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ras/dephosph-GAP /kinetics/chain/kinetics[10]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[10]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[10]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[10]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[10]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[9]/Ras/GAP/diff /kinetics/chain/kinetics[10]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[10]/Ras/GAP/diff /kinetics/chain/kinetics[10]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/GTP-Ras /kinetics/chain/kinetics[10]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/GAP /kinetics/chain/kinetics[10]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[10]/Ras/GAP /kinetics/chain/kinetics[10]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/GAP /kinetics/chain/kinetics[10]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF /kinetics/chain/kinetics[10]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/CaM-GEF /kinetics/chain/kinetics[10]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca4 /kinetics/chain/kinetics[10]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[10]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[10]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[10]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[9]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[10]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[10]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[10]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[10]/Ras/GDP-Ras /kinetics/chain/kinetics[10]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ras/CaM-GEF /kinetics/chain/kinetics[10]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[10]/Ras/CaM-GEF /kinetics/chain/kinetics[10]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/CaM-GEF /kinetics/chain/kinetics[10]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[10]/Ca REAC A B addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[10]/Ca REAC A B addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[10]/Ca REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[10]/Ca REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[10]/Ca REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[10]/Ca REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[10]/Ca REAC A B addmsg /kinetics/chain/kinetics[10]/Ca_diff /kinetics/chain/kinetics[10]/Ca REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[10]/DAG REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG /kinetics/chain/kinetics[10]/DAG REAC A B addmsg /kinetics/chain/kinetics[10]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[10]/DAG REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[10]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[10]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[10]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[10]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[10]/PKC/PKC-basal* /kinetics/chain/kinetics[10]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[10]/PKC/PKC-AA* /kinetics/chain/kinetics[10]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[10]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[10]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[10]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[10]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[10]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[10]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[10]/PKC-active/phosph-AC2 /kinetics/chain/kinetics[10]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1 /kinetics/chain/kinetics[10]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC-active /kinetics/chain/kinetics[10]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[10]/Ras/GAP /kinetics/chain/kinetics[10]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC-active /kinetics/chain/kinetics[10]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF /kinetics/chain/kinetics[10]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PKC-active /kinetics/chain/kinetics[10]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[10]/PKC-active /kinetics/chain/kinetics[10]/PKC-active/phosph-AC2 ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[10]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MAPK*/MAPK* /kinetics/chain/kinetics[10]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[10]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[10]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[10]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[10]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[9]/MAPK*/diff /kinetics/chain/kinetics[10]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[10]/MAPK*/diff /kinetics/chain/kinetics[10]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[10]/MAPK*/MAPK* SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK* /kinetics/chain/kinetics[10]/MAPK*/MAPK* ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1* /kinetics/chain/kinetics[10]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK* /kinetics/chain/kinetics[10]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK* /kinetics/chain/kinetics[10]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK* /kinetics/chain/kinetics[10]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[10]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[10]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[10]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[9]/MKP-1/diff /kinetics/chain/kinetics[10]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[10]/MKP-1/diff /kinetics/chain/kinetics[10]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr /kinetics/chain/kinetics[10]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MKP-1 /kinetics/chain/kinetics[10]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK* /kinetics/chain/kinetics[10]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MKP-1 /kinetics/chain/kinetics[10]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[10]/MKP-1 /kinetics/chain/kinetics[10]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MKP-1 /kinetics/chain/kinetics[10]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[10]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[10]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[10]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[10]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[9]/PPhosphatase2A/diff /kinetics/chain/kinetics[10]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/diff /kinetics/chain/kinetics[10]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1* /kinetics/chain/kinetics[10]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A /kinetics/chain/kinetics[10]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK* /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1** /kinetics/chain/kinetics[10]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A /kinetics/chain/kinetics[10]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A /kinetics/chain/kinetics[10]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A /kinetics/chain/kinetics[10]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[10]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM/diff /kinetics/chain/kinetics[10]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[10]/CaM/CaM/diff /kinetics/chain/kinetics[10]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM /kinetics/chain/kinetics[10]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM /kinetics/chain/kinetics[10]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ca /kinetics/chain/kinetics[10]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ca /kinetics/chain/kinetics[10]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM /kinetics/chain/kinetics[10]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[10]/CaM/CaM-TR2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ca /kinetics/chain/kinetics[10]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca3 /kinetics/chain/kinetics[10]/CaM/CaM-TR2-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[10]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca3 /kinetics/chain/kinetics[10]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca4 /kinetics/chain/kinetics[10]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[10]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[10]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca3 /kinetics/chain/kinetics[10]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca3 /kinetics/chain/kinetics[10]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[10]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[10]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[10]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[9]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[10]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[10]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[10]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[10]/CaM/CaM-TR2-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[10]/CaM/CaM-TR2-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[10]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[10]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[9]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[10]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[10]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca4 /kinetics/chain/kinetics[10]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca4 /kinetics/chain/kinetics[10]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/MAPK/craf-1 /kinetics/chain/kinetics[10]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[10]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ras/GTP-Ras /kinetics/chain/kinetics[10]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[10]/Ca_diff /kinetics/chain/kinetics[10]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[10]/Ca /kinetics/chain/kinetics[10]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[10]/Ca_input /kinetics/chain/kinetics[10]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[11]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[11]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[11]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[11]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[11]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[11]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca /kinetics/chain/kinetics[11]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca /kinetics/chain/kinetics[11]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ca /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca /kinetics/chain/kinetics[11]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[11]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[11]/DAG /kinetics/chain/kinetics[11]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca /kinetics/chain/kinetics[11]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[11]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[11]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[11]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca-AA PRODUCT n addmsg /kinetics/chain/kinetics[11]/AA /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[11]/PKC/PKC-act-by-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[11]/PKC/PKC-act-by-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[11]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[11]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[11]/PKC/PKC-DAG-AA* REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[11]/PKC/PKC-DAG-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[11]/PKC/PKC-DAG-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[11]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[11]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[11]/PKC/PKC-Ca-AA* REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[11]/PKC/PKC-Ca-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[11]/PKC/PKC-Ca-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-basal-act /kinetics/chain/kinetics[11]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[11]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[11]/PKC/PKC-basal* REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-basal* /kinetics/chain/kinetics[11]/PKC/PKC-basal*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-basal* /kinetics/chain/kinetics[11]/PKC/PKC-basal*/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-basal* /kinetics/chain/kinetics[11]/PKC/PKC-basal-act PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic /kinetics/chain/kinetics[11]/PKC/PKC-basal-act SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[11]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[11]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[11]/PKC/PKC-AA* REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-AA* /kinetics/chain/kinetics[11]/PKC/PKC-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-AA* /kinetics/chain/kinetics[11]/PKC/PKC-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-AA* /kinetics/chain/kinetics[11]/PKC/PKC-act-by-AA PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic /kinetics/chain/kinetics[11]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/AA /kinetics/chain/kinetics[11]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/DAG /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG /kinetics/chain/kinetics[11]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[11]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[11]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[11]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG /kinetics/chain/kinetics[11]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG /kinetics/chain/kinetics[11]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[11]/AA /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[11]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[11]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[10]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[11]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[11]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[11]/PKC/PKC-DAG-AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[11]/PKC/PKC-DAG-AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-basal-act /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[11]/AA REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[11]/AA REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[11]/AA REAC A B addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[11]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[11]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[11]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[11]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[11]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[11]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[11]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[11]/PLA2/Degrade-AA /kinetics/chain/kinetics[11]/AA REAC A B addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[11]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[10]/AA/diff /kinetics/chain/kinetics[11]/AA REAC B A addmsg /kinetics/chain/kinetics[11]/AA/diff /kinetics/chain/kinetics[11]/AA REAC A B addmsg /kinetics/chain/kinetics[11]/AA /kinetics/chain/kinetics[11]/AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/AA /kinetics/chain/kinetics[11]/AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[11]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[11]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[11]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[11]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[11]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[11]/MAPK*/MAPK* /kinetics/chain/kinetics[11]/PLA2/PLA2-cytosolic REAC sA B addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[11]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[11]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[11]/PLA2/PLA2-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[11]/PLA2/PLA2-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ca /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca* REAC eA B addmsg /kinetics/chain/kinetics[11]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[11]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca*/kenz ENZYME n addmsg /kinetics/chain/kinetics[11]/PLA2/APC /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca*/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[11]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[11]/PLA2/PIP2-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[11]/temp-PIP2 /kinetics/chain/kinetics[11]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[11]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[11]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[11]/PLA2/PIP2-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[10]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[11]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[11]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[11]/PLA2/PIP2-PLA2* REAC A B addmsg /kinetics/chain/kinetics[11]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[11]/PLA2/PIP2-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[11]/PLA2/APC /kinetics/chain/kinetics[11]/PLA2/PIP2-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[11]/PLA2/PIP2-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[11]/PLA2/PIP2-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[11]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[11]/PLA2/PIP2-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[11]/temp-PIP2 /kinetics/chain/kinetics[11]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[11]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[11]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[11]/PLA2/PIP2-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[10]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[11]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[11]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[11]/PLA2/PIP2-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[11]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[11]/PLA2/PIP2-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[11]/PLA2/APC /kinetics/chain/kinetics[11]/PLA2/PIP2-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[11]/PLA2/PIP2-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[11]/PLA2/PIP2-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[11]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[11]/PLA2/DAG-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[11]/DAG /kinetics/chain/kinetics[11]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[11]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[11]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[11]/PLA2/DAG-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[10]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[11]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[11]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[11]/PLA2/DAG-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[11]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[11]/PLA2/DAG-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[11]/PLA2/APC /kinetics/chain/kinetics[11]/PLA2/DAG-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[11]/PLA2/DAG-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[11]/PLA2/DAG-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[11]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[11]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[11]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[11]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[11]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[11]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[11]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[11]/PLA2/Degrade-AA /kinetics/chain/kinetics[11]/PLA2/APC REAC B A addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[11]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[11]/AA /kinetics/chain/kinetics[11]/PLA2/Degrade-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PLA2/APC /kinetics/chain/kinetics[11]/PLA2/Degrade-AA PRODUCT n addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca REAC eA B addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca REAC A B addmsg /kinetics/chain/kinetics[11]/PLA2/APC /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca/kenz ENZYME n addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[11]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[11]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[11]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[11]/MAPK*/MAPK* /kinetics/chain/kinetics[11]/PLA2/PLA2* MM_PRD pA addmsg /kinetics/chain/kinetics[10]/PLA2/PLA2*/diff /kinetics/chain/kinetics[11]/PLA2/PLA2* REAC B A addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2*/diff /kinetics/chain/kinetics[11]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2* /kinetics/chain/kinetics[11]/PLA2/PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2* /kinetics/chain/kinetics[11]/PLA2/PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2* /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ca /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[11]/PLA2/dephosphorylate-PLA2* PRODUCT n addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2* /kinetics/chain/kinetics[11]/PLA2/dephosphorylate-PLA2* SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[11]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[11]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[11]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[11]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[11]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[11]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[11]/Ras-act-unphosph-raf /kinetics/chain/kinetics[11]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[11]/Ras-act-craf /kinetics/chain/kinetics[11]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[11]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[11]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[11]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[11]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[11]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[11]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[11]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[11]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[11]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[11]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[11]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK/diff /kinetics/chain/kinetics[11]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK/diff /kinetics/chain/kinetics[11]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK /kinetics/chain/kinetics[11]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK /kinetics/chain/kinetics[11]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[11]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[11]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[11]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[11]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[11]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[11]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[11]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[11]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[11]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK* /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK* /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[11]/Ras-act-unphosph-raf /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[11]/Ras-act-craf /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1* /kinetics/chain/kinetics[11]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[11]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ras/GTP-Ras /kinetics/chain/kinetics[11]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF /kinetics/chain/kinetics[11]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ras/GEF* /kinetics/chain/kinetics[11]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/dephosph-GEF /kinetics/chain/kinetics[11]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[11]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[11]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[11]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[11]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[11]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[10]/Ras/inact-GEF/diff /kinetics/chain/kinetics[11]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF/diff /kinetics/chain/kinetics[11]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF /kinetics/chain/kinetics[11]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[11]/Ras/GDP-Ras /kinetics/chain/kinetics[11]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF /kinetics/chain/kinetics[11]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF /kinetics/chain/kinetics[11]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ras/dephosph-GEF /kinetics/chain/kinetics[11]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[11]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[11]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[11]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[10]/Ras/GEF*/diff /kinetics/chain/kinetics[11]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[11]/Ras/GEF*/diff /kinetics/chain/kinetics[11]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/GEF* /kinetics/chain/kinetics[11]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[11]/Ras/GDP-Ras /kinetics/chain/kinetics[11]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/GEF* /kinetics/chain/kinetics[11]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/GEF* /kinetics/chain/kinetics[11]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ras-act-craf /kinetics/chain/kinetics[11]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[11]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[11]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[11]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[11]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[11]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[11]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[11]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[11]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[11]/Ras-act-unphosph-raf /kinetics/chain/kinetics[11]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[11]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[11]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[11]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[11]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[11]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[11]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[11]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[11]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[11]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[11]/Ras/GTP-Ras /kinetics/chain/kinetics[11]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/GDP-Ras /kinetics/chain/kinetics[11]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ras/GAP* /kinetics/chain/kinetics[11]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/GAP /kinetics/chain/kinetics[11]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ras/dephosph-GAP /kinetics/chain/kinetics[11]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[11]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[11]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[10]/Ras/GAP*/diff /kinetics/chain/kinetics[11]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[11]/Ras/GAP*/diff /kinetics/chain/kinetics[11]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/GAP* /kinetics/chain/kinetics[11]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/GAP* /kinetics/chain/kinetics[11]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ras/dephosph-GAP /kinetics/chain/kinetics[11]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[11]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[11]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[11]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[11]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[10]/Ras/GAP/diff /kinetics/chain/kinetics[11]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[11]/Ras/GAP/diff /kinetics/chain/kinetics[11]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/GTP-Ras /kinetics/chain/kinetics[11]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/GAP /kinetics/chain/kinetics[11]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[11]/Ras/GAP /kinetics/chain/kinetics[11]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/GAP /kinetics/chain/kinetics[11]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF /kinetics/chain/kinetics[11]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/CaM-GEF /kinetics/chain/kinetics[11]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca4 /kinetics/chain/kinetics[11]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[11]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[11]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[11]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[10]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[11]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[11]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[11]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[11]/Ras/GDP-Ras /kinetics/chain/kinetics[11]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ras/CaM-GEF /kinetics/chain/kinetics[11]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[11]/Ras/CaM-GEF /kinetics/chain/kinetics[11]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/CaM-GEF /kinetics/chain/kinetics[11]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[11]/Ca REAC A B addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[11]/Ca REAC A B addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[11]/Ca REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[11]/Ca REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[11]/Ca REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[11]/Ca REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[11]/Ca REAC A B addmsg /kinetics/chain/kinetics[11]/Ca_diff /kinetics/chain/kinetics[11]/Ca REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[11]/DAG REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG /kinetics/chain/kinetics[11]/DAG REAC A B addmsg /kinetics/chain/kinetics[11]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[11]/DAG REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[11]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[11]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[11]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[11]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[11]/PKC/PKC-basal* /kinetics/chain/kinetics[11]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[11]/PKC/PKC-AA* /kinetics/chain/kinetics[11]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[11]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[11]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[11]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[11]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[11]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[11]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[11]/PKC-active/phosph-AC2 /kinetics/chain/kinetics[11]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1 /kinetics/chain/kinetics[11]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC-active /kinetics/chain/kinetics[11]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[11]/Ras/GAP /kinetics/chain/kinetics[11]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC-active /kinetics/chain/kinetics[11]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF /kinetics/chain/kinetics[11]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PKC-active /kinetics/chain/kinetics[11]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[11]/PKC-active /kinetics/chain/kinetics[11]/PKC-active/phosph-AC2 ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[11]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MAPK*/MAPK* /kinetics/chain/kinetics[11]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[11]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[11]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[11]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[11]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[10]/MAPK*/diff /kinetics/chain/kinetics[11]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[11]/MAPK*/diff /kinetics/chain/kinetics[11]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[11]/MAPK*/MAPK* SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK* /kinetics/chain/kinetics[11]/MAPK*/MAPK* ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1* /kinetics/chain/kinetics[11]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK* /kinetics/chain/kinetics[11]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK* /kinetics/chain/kinetics[11]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK* /kinetics/chain/kinetics[11]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[11]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[11]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[11]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[10]/MKP-1/diff /kinetics/chain/kinetics[11]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[11]/MKP-1/diff /kinetics/chain/kinetics[11]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr /kinetics/chain/kinetics[11]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MKP-1 /kinetics/chain/kinetics[11]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK* /kinetics/chain/kinetics[11]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MKP-1 /kinetics/chain/kinetics[11]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[11]/MKP-1 /kinetics/chain/kinetics[11]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MKP-1 /kinetics/chain/kinetics[11]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[11]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[11]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[11]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[11]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[10]/PPhosphatase2A/diff /kinetics/chain/kinetics[11]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/diff /kinetics/chain/kinetics[11]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1* /kinetics/chain/kinetics[11]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A /kinetics/chain/kinetics[11]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK* /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1** /kinetics/chain/kinetics[11]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A /kinetics/chain/kinetics[11]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A /kinetics/chain/kinetics[11]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A /kinetics/chain/kinetics[11]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[11]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM/diff /kinetics/chain/kinetics[11]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[11]/CaM/CaM/diff /kinetics/chain/kinetics[11]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM /kinetics/chain/kinetics[11]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM /kinetics/chain/kinetics[11]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ca /kinetics/chain/kinetics[11]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ca /kinetics/chain/kinetics[11]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM /kinetics/chain/kinetics[11]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[11]/CaM/CaM-TR2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ca /kinetics/chain/kinetics[11]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca3 /kinetics/chain/kinetics[11]/CaM/CaM-TR2-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[11]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca3 /kinetics/chain/kinetics[11]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca4 /kinetics/chain/kinetics[11]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[11]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[11]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca3 /kinetics/chain/kinetics[11]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca3 /kinetics/chain/kinetics[11]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[11]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[11]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[11]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[10]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[11]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[11]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[11]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[11]/CaM/CaM-TR2-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[11]/CaM/CaM-TR2-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[11]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[11]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[10]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[11]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[11]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca4 /kinetics/chain/kinetics[11]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 /kinetics/chain/kinetics[11]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/MAPK/craf-1 /kinetics/chain/kinetics[11]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[11]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ras/GTP-Ras /kinetics/chain/kinetics[11]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[11]/Ca_diff /kinetics/chain/kinetics[11]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[11]/Ca /kinetics/chain/kinetics[11]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[11]/Ca_input /kinetics/chain/kinetics[11]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[12]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[12]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[12]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[12]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[12]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[12]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca /kinetics/chain/kinetics[12]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca /kinetics/chain/kinetics[12]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ca /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca /kinetics/chain/kinetics[12]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[12]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[12]/DAG /kinetics/chain/kinetics[12]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca /kinetics/chain/kinetics[12]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[12]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[12]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[12]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca-AA PRODUCT n addmsg /kinetics/chain/kinetics[12]/AA /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[12]/PKC/PKC-act-by-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[12]/PKC/PKC-act-by-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[12]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[12]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[12]/PKC/PKC-DAG-AA* REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[12]/PKC/PKC-DAG-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[12]/PKC/PKC-DAG-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[12]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[12]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[12]/PKC/PKC-Ca-AA* REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[12]/PKC/PKC-Ca-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[12]/PKC/PKC-Ca-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-basal-act /kinetics/chain/kinetics[12]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[12]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[12]/PKC/PKC-basal* REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-basal* /kinetics/chain/kinetics[12]/PKC/PKC-basal*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-basal* /kinetics/chain/kinetics[12]/PKC/PKC-basal*/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-basal* /kinetics/chain/kinetics[12]/PKC/PKC-basal-act PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic /kinetics/chain/kinetics[12]/PKC/PKC-basal-act SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[12]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[12]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[12]/PKC/PKC-AA* REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-AA* /kinetics/chain/kinetics[12]/PKC/PKC-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-AA* /kinetics/chain/kinetics[12]/PKC/PKC-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-AA* /kinetics/chain/kinetics[12]/PKC/PKC-act-by-AA PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic /kinetics/chain/kinetics[12]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/AA /kinetics/chain/kinetics[12]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/DAG /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG /kinetics/chain/kinetics[12]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[12]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[12]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[12]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG /kinetics/chain/kinetics[12]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG /kinetics/chain/kinetics[12]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[12]/AA /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[12]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[12]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[11]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[12]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[12]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[12]/PKC/PKC-DAG-AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[12]/PKC/PKC-DAG-AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-basal-act /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[12]/AA REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[12]/AA REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[12]/AA REAC A B addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[12]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[12]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[12]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[12]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[12]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[12]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[12]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[12]/PLA2/Degrade-AA /kinetics/chain/kinetics[12]/AA REAC A B addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[12]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[11]/AA/diff /kinetics/chain/kinetics[12]/AA REAC B A addmsg /kinetics/chain/kinetics[12]/AA/diff /kinetics/chain/kinetics[12]/AA REAC A B addmsg /kinetics/chain/kinetics[12]/AA /kinetics/chain/kinetics[12]/AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/AA /kinetics/chain/kinetics[12]/AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[12]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[12]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[12]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[12]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[12]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[12]/MAPK*/MAPK* /kinetics/chain/kinetics[12]/PLA2/PLA2-cytosolic REAC sA B addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[12]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[12]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[12]/PLA2/PLA2-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[12]/PLA2/PLA2-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ca /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca* REAC eA B addmsg /kinetics/chain/kinetics[12]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[12]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca*/kenz ENZYME n addmsg /kinetics/chain/kinetics[12]/PLA2/APC /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca*/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[12]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[12]/PLA2/PIP2-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[12]/temp-PIP2 /kinetics/chain/kinetics[12]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[12]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[12]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[12]/PLA2/PIP2-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[11]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[12]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[12]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[12]/PLA2/PIP2-PLA2* REAC A B addmsg /kinetics/chain/kinetics[12]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[12]/PLA2/PIP2-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[12]/PLA2/APC /kinetics/chain/kinetics[12]/PLA2/PIP2-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[12]/PLA2/PIP2-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[12]/PLA2/PIP2-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[12]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[12]/PLA2/PIP2-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[12]/temp-PIP2 /kinetics/chain/kinetics[12]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[12]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[12]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[12]/PLA2/PIP2-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[11]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[12]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[12]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[12]/PLA2/PIP2-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[12]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[12]/PLA2/PIP2-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[12]/PLA2/APC /kinetics/chain/kinetics[12]/PLA2/PIP2-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[12]/PLA2/PIP2-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[12]/PLA2/PIP2-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[12]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[12]/PLA2/DAG-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[12]/DAG /kinetics/chain/kinetics[12]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[12]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[12]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[12]/PLA2/DAG-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[11]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[12]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[12]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[12]/PLA2/DAG-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[12]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[12]/PLA2/DAG-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[12]/PLA2/APC /kinetics/chain/kinetics[12]/PLA2/DAG-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[12]/PLA2/DAG-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[12]/PLA2/DAG-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[12]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[12]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[12]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[12]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[12]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[12]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[12]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[12]/PLA2/Degrade-AA /kinetics/chain/kinetics[12]/PLA2/APC REAC B A addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[12]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[12]/AA /kinetics/chain/kinetics[12]/PLA2/Degrade-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PLA2/APC /kinetics/chain/kinetics[12]/PLA2/Degrade-AA PRODUCT n addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca REAC eA B addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca REAC A B addmsg /kinetics/chain/kinetics[12]/PLA2/APC /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca/kenz ENZYME n addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[12]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[12]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[12]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[12]/MAPK*/MAPK* /kinetics/chain/kinetics[12]/PLA2/PLA2* MM_PRD pA addmsg /kinetics/chain/kinetics[11]/PLA2/PLA2*/diff /kinetics/chain/kinetics[12]/PLA2/PLA2* REAC B A addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2*/diff /kinetics/chain/kinetics[12]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2* /kinetics/chain/kinetics[12]/PLA2/PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2* /kinetics/chain/kinetics[12]/PLA2/PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2* /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ca /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[12]/PLA2/dephosphorylate-PLA2* PRODUCT n addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2* /kinetics/chain/kinetics[12]/PLA2/dephosphorylate-PLA2* SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[12]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[12]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[12]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[12]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[12]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[12]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[12]/Ras-act-unphosph-raf /kinetics/chain/kinetics[12]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[12]/Ras-act-craf /kinetics/chain/kinetics[12]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[12]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[12]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[12]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[12]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[12]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[12]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[12]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[12]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[12]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[12]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[12]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK/diff /kinetics/chain/kinetics[12]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK/diff /kinetics/chain/kinetics[12]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK /kinetics/chain/kinetics[12]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK /kinetics/chain/kinetics[12]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[12]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[12]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[12]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[12]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[12]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[12]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[12]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[12]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[12]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK* /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK* /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[12]/Ras-act-unphosph-raf /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[12]/Ras-act-craf /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1* /kinetics/chain/kinetics[12]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[12]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ras/GTP-Ras /kinetics/chain/kinetics[12]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF /kinetics/chain/kinetics[12]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ras/GEF* /kinetics/chain/kinetics[12]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/dephosph-GEF /kinetics/chain/kinetics[12]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[12]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[12]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[12]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[12]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[12]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[11]/Ras/inact-GEF/diff /kinetics/chain/kinetics[12]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF/diff /kinetics/chain/kinetics[12]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF /kinetics/chain/kinetics[12]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[12]/Ras/GDP-Ras /kinetics/chain/kinetics[12]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF /kinetics/chain/kinetics[12]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF /kinetics/chain/kinetics[12]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ras/dephosph-GEF /kinetics/chain/kinetics[12]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[12]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[12]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[12]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[11]/Ras/GEF*/diff /kinetics/chain/kinetics[12]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[12]/Ras/GEF*/diff /kinetics/chain/kinetics[12]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/GEF* /kinetics/chain/kinetics[12]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[12]/Ras/GDP-Ras /kinetics/chain/kinetics[12]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/GEF* /kinetics/chain/kinetics[12]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/GEF* /kinetics/chain/kinetics[12]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ras-act-craf /kinetics/chain/kinetics[12]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[12]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[12]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[12]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[12]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[12]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[12]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[12]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[12]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[12]/Ras-act-unphosph-raf /kinetics/chain/kinetics[12]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[12]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[12]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[12]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[12]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[12]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[12]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[12]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[12]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[12]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[12]/Ras/GTP-Ras /kinetics/chain/kinetics[12]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/GDP-Ras /kinetics/chain/kinetics[12]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ras/GAP* /kinetics/chain/kinetics[12]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/GAP /kinetics/chain/kinetics[12]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ras/dephosph-GAP /kinetics/chain/kinetics[12]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[12]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[12]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[11]/Ras/GAP*/diff /kinetics/chain/kinetics[12]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[12]/Ras/GAP*/diff /kinetics/chain/kinetics[12]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/GAP* /kinetics/chain/kinetics[12]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/GAP* /kinetics/chain/kinetics[12]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ras/dephosph-GAP /kinetics/chain/kinetics[12]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[12]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[12]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[12]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[12]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[11]/Ras/GAP/diff /kinetics/chain/kinetics[12]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[12]/Ras/GAP/diff /kinetics/chain/kinetics[12]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/GTP-Ras /kinetics/chain/kinetics[12]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/GAP /kinetics/chain/kinetics[12]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[12]/Ras/GAP /kinetics/chain/kinetics[12]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/GAP /kinetics/chain/kinetics[12]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF /kinetics/chain/kinetics[12]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/CaM-GEF /kinetics/chain/kinetics[12]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 /kinetics/chain/kinetics[12]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[12]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[12]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[12]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[11]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[12]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[12]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[12]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[12]/Ras/GDP-Ras /kinetics/chain/kinetics[12]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ras/CaM-GEF /kinetics/chain/kinetics[12]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[12]/Ras/CaM-GEF /kinetics/chain/kinetics[12]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/CaM-GEF /kinetics/chain/kinetics[12]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[12]/Ca REAC A B addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[12]/Ca REAC A B addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[12]/Ca REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[12]/Ca REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[12]/Ca REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[12]/Ca REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[12]/Ca REAC A B addmsg /kinetics/chain/kinetics[12]/Ca_diff /kinetics/chain/kinetics[12]/Ca REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[12]/DAG REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG /kinetics/chain/kinetics[12]/DAG REAC A B addmsg /kinetics/chain/kinetics[12]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[12]/DAG REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[12]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[12]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[12]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[12]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[12]/PKC/PKC-basal* /kinetics/chain/kinetics[12]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[12]/PKC/PKC-AA* /kinetics/chain/kinetics[12]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[12]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[12]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[12]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[12]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[12]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[12]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[12]/PKC-active/phosph-AC2 /kinetics/chain/kinetics[12]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1 /kinetics/chain/kinetics[12]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC-active /kinetics/chain/kinetics[12]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[12]/Ras/GAP /kinetics/chain/kinetics[12]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC-active /kinetics/chain/kinetics[12]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF /kinetics/chain/kinetics[12]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PKC-active /kinetics/chain/kinetics[12]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[12]/PKC-active /kinetics/chain/kinetics[12]/PKC-active/phosph-AC2 ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[12]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MAPK*/MAPK* /kinetics/chain/kinetics[12]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[12]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[12]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[12]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[12]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[11]/MAPK*/diff /kinetics/chain/kinetics[12]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[12]/MAPK*/diff /kinetics/chain/kinetics[12]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[12]/MAPK*/MAPK* SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK* /kinetics/chain/kinetics[12]/MAPK*/MAPK* ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1* /kinetics/chain/kinetics[12]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK* /kinetics/chain/kinetics[12]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK* /kinetics/chain/kinetics[12]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK* /kinetics/chain/kinetics[12]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[12]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[12]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[12]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[11]/MKP-1/diff /kinetics/chain/kinetics[12]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[12]/MKP-1/diff /kinetics/chain/kinetics[12]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr /kinetics/chain/kinetics[12]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MKP-1 /kinetics/chain/kinetics[12]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK* /kinetics/chain/kinetics[12]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MKP-1 /kinetics/chain/kinetics[12]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[12]/MKP-1 /kinetics/chain/kinetics[12]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MKP-1 /kinetics/chain/kinetics[12]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[12]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[12]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[12]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[12]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[11]/PPhosphatase2A/diff /kinetics/chain/kinetics[12]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/diff /kinetics/chain/kinetics[12]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1* /kinetics/chain/kinetics[12]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A /kinetics/chain/kinetics[12]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK* /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1** /kinetics/chain/kinetics[12]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A /kinetics/chain/kinetics[12]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A /kinetics/chain/kinetics[12]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A /kinetics/chain/kinetics[12]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[12]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM/diff /kinetics/chain/kinetics[12]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[12]/CaM/CaM/diff /kinetics/chain/kinetics[12]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM /kinetics/chain/kinetics[12]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM /kinetics/chain/kinetics[12]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ca /kinetics/chain/kinetics[12]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ca /kinetics/chain/kinetics[12]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM /kinetics/chain/kinetics[12]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[12]/CaM/CaM-TR2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ca /kinetics/chain/kinetics[12]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca3 /kinetics/chain/kinetics[12]/CaM/CaM-TR2-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[12]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca3 /kinetics/chain/kinetics[12]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 /kinetics/chain/kinetics[12]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[12]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[12]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca3 /kinetics/chain/kinetics[12]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca3 /kinetics/chain/kinetics[12]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[12]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[12]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[12]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[11]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[12]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[12]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[12]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[12]/CaM/CaM-TR2-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[12]/CaM/CaM-TR2-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[11]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca4 /kinetics/chain/kinetics[12]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca4 /kinetics/chain/kinetics[12]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/MAPK/craf-1 /kinetics/chain/kinetics[12]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[12]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ras/GTP-Ras /kinetics/chain/kinetics[12]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[12]/Ca_diff /kinetics/chain/kinetics[12]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[12]/Ca /kinetics/chain/kinetics[12]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[12]/Ca_input /kinetics/chain/kinetics[12]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[13]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[13]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[13]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[13]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[13]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[13]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca /kinetics/chain/kinetics[13]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca /kinetics/chain/kinetics[13]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ca /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca /kinetics/chain/kinetics[13]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[13]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[13]/DAG /kinetics/chain/kinetics[13]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca /kinetics/chain/kinetics[13]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[13]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[13]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[13]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca-AA PRODUCT n addmsg /kinetics/chain/kinetics[13]/AA /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[13]/PKC/PKC-act-by-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[13]/PKC/PKC-act-by-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[13]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[13]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[13]/PKC/PKC-DAG-AA* REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[13]/PKC/PKC-DAG-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[13]/PKC/PKC-DAG-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[13]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[13]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[13]/PKC/PKC-Ca-AA* REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[13]/PKC/PKC-Ca-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[13]/PKC/PKC-Ca-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-basal-act /kinetics/chain/kinetics[13]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[13]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[13]/PKC/PKC-basal* REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-basal* /kinetics/chain/kinetics[13]/PKC/PKC-basal*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-basal* /kinetics/chain/kinetics[13]/PKC/PKC-basal*/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-basal* /kinetics/chain/kinetics[13]/PKC/PKC-basal-act PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic /kinetics/chain/kinetics[13]/PKC/PKC-basal-act SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[13]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[13]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[13]/PKC/PKC-AA* REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-AA* /kinetics/chain/kinetics[13]/PKC/PKC-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-AA* /kinetics/chain/kinetics[13]/PKC/PKC-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-AA* /kinetics/chain/kinetics[13]/PKC/PKC-act-by-AA PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic /kinetics/chain/kinetics[13]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/AA /kinetics/chain/kinetics[13]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/DAG /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG /kinetics/chain/kinetics[13]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[13]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[13]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[13]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG /kinetics/chain/kinetics[13]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG /kinetics/chain/kinetics[13]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[13]/AA /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[13]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[13]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[12]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[13]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[13]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[13]/PKC/PKC-DAG-AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[13]/PKC/PKC-DAG-AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-basal-act /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[13]/AA REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[13]/AA REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[13]/AA REAC A B addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[13]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[13]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[13]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[13]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[13]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[13]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[13]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[13]/PLA2/Degrade-AA /kinetics/chain/kinetics[13]/AA REAC A B addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[13]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[12]/AA/diff /kinetics/chain/kinetics[13]/AA REAC B A addmsg /kinetics/chain/kinetics[13]/AA/diff /kinetics/chain/kinetics[13]/AA REAC A B addmsg /kinetics/chain/kinetics[13]/AA /kinetics/chain/kinetics[13]/AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/AA /kinetics/chain/kinetics[13]/AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[13]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[13]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[13]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[13]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[13]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[13]/MAPK*/MAPK* /kinetics/chain/kinetics[13]/PLA2/PLA2-cytosolic REAC sA B addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[13]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[13]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[13]/PLA2/PLA2-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[13]/PLA2/PLA2-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ca /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca* REAC eA B addmsg /kinetics/chain/kinetics[13]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[13]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca*/kenz ENZYME n addmsg /kinetics/chain/kinetics[13]/PLA2/APC /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca*/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[13]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[13]/PLA2/PIP2-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[13]/temp-PIP2 /kinetics/chain/kinetics[13]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[13]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[13]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[13]/PLA2/PIP2-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[12]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[13]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[13]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[13]/PLA2/PIP2-PLA2* REAC A B addmsg /kinetics/chain/kinetics[13]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[13]/PLA2/PIP2-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[13]/PLA2/APC /kinetics/chain/kinetics[13]/PLA2/PIP2-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[13]/PLA2/PIP2-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[13]/PLA2/PIP2-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[13]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[13]/PLA2/PIP2-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[13]/temp-PIP2 /kinetics/chain/kinetics[13]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[13]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[13]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[13]/PLA2/PIP2-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[12]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[13]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[13]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[13]/PLA2/PIP2-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[13]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[13]/PLA2/PIP2-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[13]/PLA2/APC /kinetics/chain/kinetics[13]/PLA2/PIP2-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[13]/PLA2/PIP2-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[13]/PLA2/PIP2-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[13]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[13]/PLA2/DAG-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[13]/DAG /kinetics/chain/kinetics[13]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[13]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[13]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[13]/PLA2/DAG-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[12]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[13]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[13]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[13]/PLA2/DAG-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[13]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[13]/PLA2/DAG-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[13]/PLA2/APC /kinetics/chain/kinetics[13]/PLA2/DAG-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[13]/PLA2/DAG-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[13]/PLA2/DAG-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[13]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[13]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[13]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[13]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[13]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[13]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[13]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[13]/PLA2/Degrade-AA /kinetics/chain/kinetics[13]/PLA2/APC REAC B A addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[13]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[13]/AA /kinetics/chain/kinetics[13]/PLA2/Degrade-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PLA2/APC /kinetics/chain/kinetics[13]/PLA2/Degrade-AA PRODUCT n addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca REAC eA B addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca REAC A B addmsg /kinetics/chain/kinetics[13]/PLA2/APC /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca/kenz ENZYME n addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[13]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[13]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[13]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[13]/MAPK*/MAPK* /kinetics/chain/kinetics[13]/PLA2/PLA2* MM_PRD pA addmsg /kinetics/chain/kinetics[12]/PLA2/PLA2*/diff /kinetics/chain/kinetics[13]/PLA2/PLA2* REAC B A addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2*/diff /kinetics/chain/kinetics[13]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2* /kinetics/chain/kinetics[13]/PLA2/PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2* /kinetics/chain/kinetics[13]/PLA2/PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2* /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ca /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[13]/PLA2/dephosphorylate-PLA2* PRODUCT n addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2* /kinetics/chain/kinetics[13]/PLA2/dephosphorylate-PLA2* SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[13]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[13]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[13]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[13]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[13]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[13]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[13]/Ras-act-unphosph-raf /kinetics/chain/kinetics[13]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[13]/Ras-act-craf /kinetics/chain/kinetics[13]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[13]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[13]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[13]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[13]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[13]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[13]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[13]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[13]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[13]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[13]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[13]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK/diff /kinetics/chain/kinetics[13]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK/diff /kinetics/chain/kinetics[13]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK /kinetics/chain/kinetics[13]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK /kinetics/chain/kinetics[13]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[13]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[13]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[13]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[13]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[13]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[13]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[13]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[13]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[13]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK* /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK* /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[13]/Ras-act-unphosph-raf /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[13]/Ras-act-craf /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1* /kinetics/chain/kinetics[13]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[13]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ras/GTP-Ras /kinetics/chain/kinetics[13]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF /kinetics/chain/kinetics[13]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ras/GEF* /kinetics/chain/kinetics[13]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/dephosph-GEF /kinetics/chain/kinetics[13]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[13]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[13]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[13]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[13]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[13]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[12]/Ras/inact-GEF/diff /kinetics/chain/kinetics[13]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF/diff /kinetics/chain/kinetics[13]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF /kinetics/chain/kinetics[13]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[13]/Ras/GDP-Ras /kinetics/chain/kinetics[13]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF /kinetics/chain/kinetics[13]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF /kinetics/chain/kinetics[13]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ras/dephosph-GEF /kinetics/chain/kinetics[13]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[13]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[13]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[13]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[12]/Ras/GEF*/diff /kinetics/chain/kinetics[13]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[13]/Ras/GEF*/diff /kinetics/chain/kinetics[13]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/GEF* /kinetics/chain/kinetics[13]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[13]/Ras/GDP-Ras /kinetics/chain/kinetics[13]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/GEF* /kinetics/chain/kinetics[13]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/GEF* /kinetics/chain/kinetics[13]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ras-act-craf /kinetics/chain/kinetics[13]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[13]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[13]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[13]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[13]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[13]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[13]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[13]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[13]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[13]/Ras-act-unphosph-raf /kinetics/chain/kinetics[13]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[13]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[13]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[13]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[13]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[13]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[13]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[13]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[13]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[13]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[13]/Ras/GTP-Ras /kinetics/chain/kinetics[13]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/GDP-Ras /kinetics/chain/kinetics[13]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ras/GAP* /kinetics/chain/kinetics[13]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/GAP /kinetics/chain/kinetics[13]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ras/dephosph-GAP /kinetics/chain/kinetics[13]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[13]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[13]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[12]/Ras/GAP*/diff /kinetics/chain/kinetics[13]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[13]/Ras/GAP*/diff /kinetics/chain/kinetics[13]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/GAP* /kinetics/chain/kinetics[13]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/GAP* /kinetics/chain/kinetics[13]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ras/dephosph-GAP /kinetics/chain/kinetics[13]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[13]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[13]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[13]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[13]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[12]/Ras/GAP/diff /kinetics/chain/kinetics[13]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[13]/Ras/GAP/diff /kinetics/chain/kinetics[13]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/GTP-Ras /kinetics/chain/kinetics[13]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/GAP /kinetics/chain/kinetics[13]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[13]/Ras/GAP /kinetics/chain/kinetics[13]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/GAP /kinetics/chain/kinetics[13]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF /kinetics/chain/kinetics[13]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/CaM-GEF /kinetics/chain/kinetics[13]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca4 /kinetics/chain/kinetics[13]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[13]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[13]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[13]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[12]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[13]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[13]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[13]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[13]/Ras/GDP-Ras /kinetics/chain/kinetics[13]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ras/CaM-GEF /kinetics/chain/kinetics[13]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[13]/Ras/CaM-GEF /kinetics/chain/kinetics[13]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/CaM-GEF /kinetics/chain/kinetics[13]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[13]/Ca REAC A B addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[13]/Ca REAC A B addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[13]/Ca REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[13]/Ca REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[13]/Ca REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[13]/Ca REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[13]/Ca REAC A B addmsg /kinetics/chain/kinetics[13]/Ca_diff /kinetics/chain/kinetics[13]/Ca REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[13]/DAG REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG /kinetics/chain/kinetics[13]/DAG REAC A B addmsg /kinetics/chain/kinetics[13]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[13]/DAG REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[13]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[13]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[13]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[13]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[13]/PKC/PKC-basal* /kinetics/chain/kinetics[13]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[13]/PKC/PKC-AA* /kinetics/chain/kinetics[13]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[13]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[13]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[13]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[13]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[13]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[13]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[13]/PKC-active/phosph-AC2 /kinetics/chain/kinetics[13]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1 /kinetics/chain/kinetics[13]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC-active /kinetics/chain/kinetics[13]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[13]/Ras/GAP /kinetics/chain/kinetics[13]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC-active /kinetics/chain/kinetics[13]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF /kinetics/chain/kinetics[13]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PKC-active /kinetics/chain/kinetics[13]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[13]/PKC-active /kinetics/chain/kinetics[13]/PKC-active/phosph-AC2 ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[13]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MAPK*/MAPK* /kinetics/chain/kinetics[13]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[13]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[13]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[13]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[13]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[12]/MAPK*/diff /kinetics/chain/kinetics[13]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[13]/MAPK*/diff /kinetics/chain/kinetics[13]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[13]/MAPK*/MAPK* SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK* /kinetics/chain/kinetics[13]/MAPK*/MAPK* ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1* /kinetics/chain/kinetics[13]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK* /kinetics/chain/kinetics[13]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK* /kinetics/chain/kinetics[13]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK* /kinetics/chain/kinetics[13]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[13]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[13]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[13]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[12]/MKP-1/diff /kinetics/chain/kinetics[13]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[13]/MKP-1/diff /kinetics/chain/kinetics[13]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr /kinetics/chain/kinetics[13]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MKP-1 /kinetics/chain/kinetics[13]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK* /kinetics/chain/kinetics[13]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MKP-1 /kinetics/chain/kinetics[13]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[13]/MKP-1 /kinetics/chain/kinetics[13]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MKP-1 /kinetics/chain/kinetics[13]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[13]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[13]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[13]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[13]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[12]/PPhosphatase2A/diff /kinetics/chain/kinetics[13]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/diff /kinetics/chain/kinetics[13]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1* /kinetics/chain/kinetics[13]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A /kinetics/chain/kinetics[13]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK* /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1** /kinetics/chain/kinetics[13]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A /kinetics/chain/kinetics[13]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A /kinetics/chain/kinetics[13]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A /kinetics/chain/kinetics[13]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[13]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM/diff /kinetics/chain/kinetics[13]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[13]/CaM/CaM/diff /kinetics/chain/kinetics[13]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM /kinetics/chain/kinetics[13]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM /kinetics/chain/kinetics[13]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ca /kinetics/chain/kinetics[13]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ca /kinetics/chain/kinetics[13]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM /kinetics/chain/kinetics[13]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[13]/CaM/CaM-TR2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ca /kinetics/chain/kinetics[13]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca3 /kinetics/chain/kinetics[13]/CaM/CaM-TR2-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[13]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca3 /kinetics/chain/kinetics[13]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca4 /kinetics/chain/kinetics[13]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[13]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[13]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca3 /kinetics/chain/kinetics[13]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca3 /kinetics/chain/kinetics[13]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[13]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[13]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[13]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[12]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[13]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[13]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[13]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[13]/CaM/CaM-TR2-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[13]/CaM/CaM-TR2-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[13]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[13]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[12]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[13]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[13]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca4 /kinetics/chain/kinetics[13]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 /kinetics/chain/kinetics[13]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/MAPK/craf-1 /kinetics/chain/kinetics[13]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[13]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ras/GTP-Ras /kinetics/chain/kinetics[13]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[13]/Ca_diff /kinetics/chain/kinetics[13]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[13]/Ca /kinetics/chain/kinetics[13]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[13]/Ca_input /kinetics/chain/kinetics[13]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[14]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[14]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[14]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[14]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[14]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[14]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca /kinetics/chain/kinetics[14]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca /kinetics/chain/kinetics[14]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ca /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca /kinetics/chain/kinetics[14]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[14]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[14]/DAG /kinetics/chain/kinetics[14]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca /kinetics/chain/kinetics[14]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[14]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[14]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[14]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca-AA PRODUCT n addmsg /kinetics/chain/kinetics[14]/AA /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[14]/PKC/PKC-act-by-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[14]/PKC/PKC-act-by-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[14]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[14]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[14]/PKC/PKC-DAG-AA* REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[14]/PKC/PKC-DAG-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[14]/PKC/PKC-DAG-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[14]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[14]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[14]/PKC/PKC-Ca-AA* REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[14]/PKC/PKC-Ca-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[14]/PKC/PKC-Ca-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-basal-act /kinetics/chain/kinetics[14]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[14]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[14]/PKC/PKC-basal* REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-basal* /kinetics/chain/kinetics[14]/PKC/PKC-basal*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-basal* /kinetics/chain/kinetics[14]/PKC/PKC-basal*/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-basal* /kinetics/chain/kinetics[14]/PKC/PKC-basal-act PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic /kinetics/chain/kinetics[14]/PKC/PKC-basal-act SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[14]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[14]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[14]/PKC/PKC-AA* REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-AA* /kinetics/chain/kinetics[14]/PKC/PKC-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-AA* /kinetics/chain/kinetics[14]/PKC/PKC-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-AA* /kinetics/chain/kinetics[14]/PKC/PKC-act-by-AA PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic /kinetics/chain/kinetics[14]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/AA /kinetics/chain/kinetics[14]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/DAG /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG /kinetics/chain/kinetics[14]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[14]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[14]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[14]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG /kinetics/chain/kinetics[14]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG /kinetics/chain/kinetics[14]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[14]/AA /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[14]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[14]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[13]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[14]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[14]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[14]/PKC/PKC-DAG-AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[14]/PKC/PKC-DAG-AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-basal-act /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[14]/AA REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[14]/AA REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[14]/AA REAC A B addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[14]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[14]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[14]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[14]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[14]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[14]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[14]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[14]/PLA2/Degrade-AA /kinetics/chain/kinetics[14]/AA REAC A B addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[14]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[13]/AA/diff /kinetics/chain/kinetics[14]/AA REAC B A addmsg /kinetics/chain/kinetics[14]/AA/diff /kinetics/chain/kinetics[14]/AA REAC A B addmsg /kinetics/chain/kinetics[14]/AA /kinetics/chain/kinetics[14]/AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/AA /kinetics/chain/kinetics[14]/AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[14]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[14]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[14]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[14]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[14]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[14]/MAPK*/MAPK* /kinetics/chain/kinetics[14]/PLA2/PLA2-cytosolic REAC sA B addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[14]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[14]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[14]/PLA2/PLA2-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[14]/PLA2/PLA2-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ca /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca* REAC eA B addmsg /kinetics/chain/kinetics[14]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[14]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca*/kenz ENZYME n addmsg /kinetics/chain/kinetics[14]/PLA2/APC /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca*/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[14]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[14]/PLA2/PIP2-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[14]/temp-PIP2 /kinetics/chain/kinetics[14]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[14]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[14]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[14]/PLA2/PIP2-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[13]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[14]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[14]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[14]/PLA2/PIP2-PLA2* REAC A B addmsg /kinetics/chain/kinetics[14]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[14]/PLA2/PIP2-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[14]/PLA2/APC /kinetics/chain/kinetics[14]/PLA2/PIP2-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[14]/PLA2/PIP2-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[14]/PLA2/PIP2-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[14]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[14]/PLA2/PIP2-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[14]/temp-PIP2 /kinetics/chain/kinetics[14]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[14]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[14]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[14]/PLA2/PIP2-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[13]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[14]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[14]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[14]/PLA2/PIP2-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[14]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[14]/PLA2/PIP2-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[14]/PLA2/APC /kinetics/chain/kinetics[14]/PLA2/PIP2-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[14]/PLA2/PIP2-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[14]/PLA2/PIP2-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[14]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[14]/PLA2/DAG-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[14]/DAG /kinetics/chain/kinetics[14]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[14]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[14]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[14]/PLA2/DAG-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[13]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[14]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[14]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[14]/PLA2/DAG-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[14]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[14]/PLA2/DAG-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[14]/PLA2/APC /kinetics/chain/kinetics[14]/PLA2/DAG-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[14]/PLA2/DAG-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[14]/PLA2/DAG-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[14]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[14]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[14]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[14]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[14]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[14]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[14]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[14]/PLA2/Degrade-AA /kinetics/chain/kinetics[14]/PLA2/APC REAC B A addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[14]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[14]/AA /kinetics/chain/kinetics[14]/PLA2/Degrade-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PLA2/APC /kinetics/chain/kinetics[14]/PLA2/Degrade-AA PRODUCT n addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca REAC eA B addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca REAC A B addmsg /kinetics/chain/kinetics[14]/PLA2/APC /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca/kenz ENZYME n addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[14]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[14]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[14]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[14]/MAPK*/MAPK* /kinetics/chain/kinetics[14]/PLA2/PLA2* MM_PRD pA addmsg /kinetics/chain/kinetics[13]/PLA2/PLA2*/diff /kinetics/chain/kinetics[14]/PLA2/PLA2* REAC B A addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2*/diff /kinetics/chain/kinetics[14]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2* /kinetics/chain/kinetics[14]/PLA2/PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2* /kinetics/chain/kinetics[14]/PLA2/PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2* /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ca /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[14]/PLA2/dephosphorylate-PLA2* PRODUCT n addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2* /kinetics/chain/kinetics[14]/PLA2/dephosphorylate-PLA2* SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[14]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[14]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[14]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[14]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[14]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[14]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[14]/Ras-act-unphosph-raf /kinetics/chain/kinetics[14]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[14]/Ras-act-craf /kinetics/chain/kinetics[14]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[14]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[14]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[14]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[14]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[14]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[14]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[14]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[14]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[14]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[14]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[14]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK/diff /kinetics/chain/kinetics[14]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK/diff /kinetics/chain/kinetics[14]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK /kinetics/chain/kinetics[14]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK /kinetics/chain/kinetics[14]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[14]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[14]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[14]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[14]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[14]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[14]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[14]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[14]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[14]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK* /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK* /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[14]/Ras-act-unphosph-raf /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[14]/Ras-act-craf /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1* /kinetics/chain/kinetics[14]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[14]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ras/GTP-Ras /kinetics/chain/kinetics[14]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF /kinetics/chain/kinetics[14]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ras/GEF* /kinetics/chain/kinetics[14]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/dephosph-GEF /kinetics/chain/kinetics[14]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[14]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[14]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[14]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[14]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[14]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[13]/Ras/inact-GEF/diff /kinetics/chain/kinetics[14]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF/diff /kinetics/chain/kinetics[14]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF /kinetics/chain/kinetics[14]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[14]/Ras/GDP-Ras /kinetics/chain/kinetics[14]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF /kinetics/chain/kinetics[14]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF /kinetics/chain/kinetics[14]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ras/dephosph-GEF /kinetics/chain/kinetics[14]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[14]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[14]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[14]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[13]/Ras/GEF*/diff /kinetics/chain/kinetics[14]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[14]/Ras/GEF*/diff /kinetics/chain/kinetics[14]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/GEF* /kinetics/chain/kinetics[14]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[14]/Ras/GDP-Ras /kinetics/chain/kinetics[14]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/GEF* /kinetics/chain/kinetics[14]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/GEF* /kinetics/chain/kinetics[14]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ras-act-craf /kinetics/chain/kinetics[14]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[14]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[14]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[14]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[14]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[14]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[14]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[14]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[14]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[14]/Ras-act-unphosph-raf /kinetics/chain/kinetics[14]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[14]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[14]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[14]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[14]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[14]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[14]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[14]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[14]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[14]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[14]/Ras/GTP-Ras /kinetics/chain/kinetics[14]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/GDP-Ras /kinetics/chain/kinetics[14]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ras/GAP* /kinetics/chain/kinetics[14]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/GAP /kinetics/chain/kinetics[14]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ras/dephosph-GAP /kinetics/chain/kinetics[14]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[14]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[14]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[13]/Ras/GAP*/diff /kinetics/chain/kinetics[14]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[14]/Ras/GAP*/diff /kinetics/chain/kinetics[14]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/GAP* /kinetics/chain/kinetics[14]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/GAP* /kinetics/chain/kinetics[14]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ras/dephosph-GAP /kinetics/chain/kinetics[14]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[14]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[14]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[14]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[14]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[13]/Ras/GAP/diff /kinetics/chain/kinetics[14]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[14]/Ras/GAP/diff /kinetics/chain/kinetics[14]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/GTP-Ras /kinetics/chain/kinetics[14]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/GAP /kinetics/chain/kinetics[14]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[14]/Ras/GAP /kinetics/chain/kinetics[14]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/GAP /kinetics/chain/kinetics[14]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF /kinetics/chain/kinetics[14]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/CaM-GEF /kinetics/chain/kinetics[14]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 /kinetics/chain/kinetics[14]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[14]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[14]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[14]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[13]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[14]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[14]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[14]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[14]/Ras/GDP-Ras /kinetics/chain/kinetics[14]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ras/CaM-GEF /kinetics/chain/kinetics[14]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[14]/Ras/CaM-GEF /kinetics/chain/kinetics[14]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/CaM-GEF /kinetics/chain/kinetics[14]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[14]/Ca REAC A B addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[14]/Ca REAC A B addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[14]/Ca REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[14]/Ca REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[14]/Ca REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[14]/Ca REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[14]/Ca REAC A B addmsg /kinetics/chain/kinetics[14]/Ca_diff /kinetics/chain/kinetics[14]/Ca REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[14]/DAG REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG /kinetics/chain/kinetics[14]/DAG REAC A B addmsg /kinetics/chain/kinetics[14]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[14]/DAG REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[14]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[14]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[14]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[14]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[14]/PKC/PKC-basal* /kinetics/chain/kinetics[14]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[14]/PKC/PKC-AA* /kinetics/chain/kinetics[14]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[14]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[14]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[14]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[14]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[14]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[14]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[14]/PKC-active/phosph-AC2 /kinetics/chain/kinetics[14]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1 /kinetics/chain/kinetics[14]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC-active /kinetics/chain/kinetics[14]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[14]/Ras/GAP /kinetics/chain/kinetics[14]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC-active /kinetics/chain/kinetics[14]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF /kinetics/chain/kinetics[14]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PKC-active /kinetics/chain/kinetics[14]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[14]/PKC-active /kinetics/chain/kinetics[14]/PKC-active/phosph-AC2 ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[14]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MAPK*/MAPK* /kinetics/chain/kinetics[14]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[14]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[14]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[14]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[14]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[13]/MAPK*/diff /kinetics/chain/kinetics[14]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[14]/MAPK*/diff /kinetics/chain/kinetics[14]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[14]/MAPK*/MAPK* SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK* /kinetics/chain/kinetics[14]/MAPK*/MAPK* ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1* /kinetics/chain/kinetics[14]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK* /kinetics/chain/kinetics[14]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK* /kinetics/chain/kinetics[14]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK* /kinetics/chain/kinetics[14]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[14]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[14]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[14]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[13]/MKP-1/diff /kinetics/chain/kinetics[14]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[14]/MKP-1/diff /kinetics/chain/kinetics[14]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr /kinetics/chain/kinetics[14]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MKP-1 /kinetics/chain/kinetics[14]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK* /kinetics/chain/kinetics[14]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MKP-1 /kinetics/chain/kinetics[14]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[14]/MKP-1 /kinetics/chain/kinetics[14]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MKP-1 /kinetics/chain/kinetics[14]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[14]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[14]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[14]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[14]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[13]/PPhosphatase2A/diff /kinetics/chain/kinetics[14]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/diff /kinetics/chain/kinetics[14]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1* /kinetics/chain/kinetics[14]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A /kinetics/chain/kinetics[14]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK* /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1** /kinetics/chain/kinetics[14]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A /kinetics/chain/kinetics[14]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A /kinetics/chain/kinetics[14]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A /kinetics/chain/kinetics[14]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[14]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM/diff /kinetics/chain/kinetics[14]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[14]/CaM/CaM/diff /kinetics/chain/kinetics[14]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM /kinetics/chain/kinetics[14]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM /kinetics/chain/kinetics[14]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ca /kinetics/chain/kinetics[14]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ca /kinetics/chain/kinetics[14]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM /kinetics/chain/kinetics[14]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[14]/CaM/CaM-TR2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ca /kinetics/chain/kinetics[14]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca3 /kinetics/chain/kinetics[14]/CaM/CaM-TR2-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[14]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca3 /kinetics/chain/kinetics[14]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 /kinetics/chain/kinetics[14]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[14]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[14]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca3 /kinetics/chain/kinetics[14]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca3 /kinetics/chain/kinetics[14]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[14]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[14]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[14]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[13]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[14]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[14]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[14]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[14]/CaM/CaM-TR2-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[14]/CaM/CaM-TR2-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[13]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca4 /kinetics/chain/kinetics[14]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca4 /kinetics/chain/kinetics[14]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/MAPK/craf-1 /kinetics/chain/kinetics[14]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[14]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ras/GTP-Ras /kinetics/chain/kinetics[14]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[14]/Ca_diff /kinetics/chain/kinetics[14]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[14]/Ca /kinetics/chain/kinetics[14]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[14]/Ca_input /kinetics/chain/kinetics[14]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[15]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[15]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[15]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[15]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[15]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[15]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca /kinetics/chain/kinetics[15]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca /kinetics/chain/kinetics[15]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ca /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca /kinetics/chain/kinetics[15]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[15]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[15]/DAG /kinetics/chain/kinetics[15]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca /kinetics/chain/kinetics[15]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[15]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[15]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[15]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca-AA PRODUCT n addmsg /kinetics/chain/kinetics[15]/AA /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[15]/PKC/PKC-act-by-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[15]/PKC/PKC-act-by-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[15]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[15]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[15]/PKC/PKC-DAG-AA* REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[15]/PKC/PKC-DAG-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[15]/PKC/PKC-DAG-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[15]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[15]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[15]/PKC/PKC-Ca-AA* REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[15]/PKC/PKC-Ca-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[15]/PKC/PKC-Ca-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-basal-act /kinetics/chain/kinetics[15]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[15]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[15]/PKC/PKC-basal* REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-basal* /kinetics/chain/kinetics[15]/PKC/PKC-basal*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-basal* /kinetics/chain/kinetics[15]/PKC/PKC-basal*/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-basal* /kinetics/chain/kinetics[15]/PKC/PKC-basal-act PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic /kinetics/chain/kinetics[15]/PKC/PKC-basal-act SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[15]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[15]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[15]/PKC/PKC-AA* REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-AA* /kinetics/chain/kinetics[15]/PKC/PKC-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-AA* /kinetics/chain/kinetics[15]/PKC/PKC-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-AA* /kinetics/chain/kinetics[15]/PKC/PKC-act-by-AA PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic /kinetics/chain/kinetics[15]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/AA /kinetics/chain/kinetics[15]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/DAG /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG /kinetics/chain/kinetics[15]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[15]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[15]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[15]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG /kinetics/chain/kinetics[15]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG /kinetics/chain/kinetics[15]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[15]/AA /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[15]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[15]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[14]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[15]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[15]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[15]/PKC/PKC-DAG-AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[15]/PKC/PKC-DAG-AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-basal-act /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[15]/AA REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[15]/AA REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[15]/AA REAC A B addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[15]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[15]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[15]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[15]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[15]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[15]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[15]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[15]/PLA2/Degrade-AA /kinetics/chain/kinetics[15]/AA REAC A B addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[15]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[14]/AA/diff /kinetics/chain/kinetics[15]/AA REAC B A addmsg /kinetics/chain/kinetics[15]/AA/diff /kinetics/chain/kinetics[15]/AA REAC A B addmsg /kinetics/chain/kinetics[15]/AA /kinetics/chain/kinetics[15]/AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/AA /kinetics/chain/kinetics[15]/AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[15]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[15]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[15]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[15]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[15]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[15]/MAPK*/MAPK* /kinetics/chain/kinetics[15]/PLA2/PLA2-cytosolic REAC sA B addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[15]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[15]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[15]/PLA2/PLA2-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[15]/PLA2/PLA2-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ca /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca* REAC eA B addmsg /kinetics/chain/kinetics[15]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[15]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca*/kenz ENZYME n addmsg /kinetics/chain/kinetics[15]/PLA2/APC /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca*/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[15]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[15]/PLA2/PIP2-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[15]/temp-PIP2 /kinetics/chain/kinetics[15]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[15]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[15]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[15]/PLA2/PIP2-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[14]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[15]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[15]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[15]/PLA2/PIP2-PLA2* REAC A B addmsg /kinetics/chain/kinetics[15]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[15]/PLA2/PIP2-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[15]/PLA2/APC /kinetics/chain/kinetics[15]/PLA2/PIP2-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[15]/PLA2/PIP2-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[15]/PLA2/PIP2-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[15]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[15]/PLA2/PIP2-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[15]/temp-PIP2 /kinetics/chain/kinetics[15]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[15]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[15]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[15]/PLA2/PIP2-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[14]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[15]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[15]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[15]/PLA2/PIP2-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[15]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[15]/PLA2/PIP2-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[15]/PLA2/APC /kinetics/chain/kinetics[15]/PLA2/PIP2-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[15]/PLA2/PIP2-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[15]/PLA2/PIP2-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[15]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[15]/PLA2/DAG-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[15]/DAG /kinetics/chain/kinetics[15]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[15]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[15]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[15]/PLA2/DAG-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[14]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[15]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[15]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[15]/PLA2/DAG-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[15]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[15]/PLA2/DAG-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[15]/PLA2/APC /kinetics/chain/kinetics[15]/PLA2/DAG-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[15]/PLA2/DAG-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[15]/PLA2/DAG-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[15]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[15]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[15]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[15]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[15]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[15]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[15]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[15]/PLA2/Degrade-AA /kinetics/chain/kinetics[15]/PLA2/APC REAC B A addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[15]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[15]/AA /kinetics/chain/kinetics[15]/PLA2/Degrade-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PLA2/APC /kinetics/chain/kinetics[15]/PLA2/Degrade-AA PRODUCT n addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca REAC eA B addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca REAC A B addmsg /kinetics/chain/kinetics[15]/PLA2/APC /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca/kenz ENZYME n addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[15]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[15]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[15]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[15]/MAPK*/MAPK* /kinetics/chain/kinetics[15]/PLA2/PLA2* MM_PRD pA addmsg /kinetics/chain/kinetics[14]/PLA2/PLA2*/diff /kinetics/chain/kinetics[15]/PLA2/PLA2* REAC B A addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2*/diff /kinetics/chain/kinetics[15]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2* /kinetics/chain/kinetics[15]/PLA2/PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2* /kinetics/chain/kinetics[15]/PLA2/PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2* /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ca /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[15]/PLA2/dephosphorylate-PLA2* PRODUCT n addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2* /kinetics/chain/kinetics[15]/PLA2/dephosphorylate-PLA2* SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[15]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[15]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[15]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[15]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[15]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[15]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[15]/Ras-act-unphosph-raf /kinetics/chain/kinetics[15]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[15]/Ras-act-craf /kinetics/chain/kinetics[15]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[15]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[15]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[15]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[15]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[15]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[15]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[15]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[15]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[15]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[15]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[15]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK/diff /kinetics/chain/kinetics[15]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK/diff /kinetics/chain/kinetics[15]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK /kinetics/chain/kinetics[15]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK /kinetics/chain/kinetics[15]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[15]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[15]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[15]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[15]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[15]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[15]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[15]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[15]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[15]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK* /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK* /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[15]/Ras-act-unphosph-raf /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[15]/Ras-act-craf /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1* /kinetics/chain/kinetics[15]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[15]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ras/GTP-Ras /kinetics/chain/kinetics[15]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF /kinetics/chain/kinetics[15]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ras/GEF* /kinetics/chain/kinetics[15]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/dephosph-GEF /kinetics/chain/kinetics[15]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[15]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[15]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[15]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[15]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[15]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[14]/Ras/inact-GEF/diff /kinetics/chain/kinetics[15]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF/diff /kinetics/chain/kinetics[15]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF /kinetics/chain/kinetics[15]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[15]/Ras/GDP-Ras /kinetics/chain/kinetics[15]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF /kinetics/chain/kinetics[15]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF /kinetics/chain/kinetics[15]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ras/dephosph-GEF /kinetics/chain/kinetics[15]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[15]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[15]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[15]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[14]/Ras/GEF*/diff /kinetics/chain/kinetics[15]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[15]/Ras/GEF*/diff /kinetics/chain/kinetics[15]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/GEF* /kinetics/chain/kinetics[15]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[15]/Ras/GDP-Ras /kinetics/chain/kinetics[15]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/GEF* /kinetics/chain/kinetics[15]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/GEF* /kinetics/chain/kinetics[15]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ras-act-craf /kinetics/chain/kinetics[15]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[15]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[15]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[15]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[15]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[15]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[15]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[15]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[15]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[15]/Ras-act-unphosph-raf /kinetics/chain/kinetics[15]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[15]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[15]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[15]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[15]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[15]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[15]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[15]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[15]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[15]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[15]/Ras/GTP-Ras /kinetics/chain/kinetics[15]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/GDP-Ras /kinetics/chain/kinetics[15]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ras/GAP* /kinetics/chain/kinetics[15]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/GAP /kinetics/chain/kinetics[15]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ras/dephosph-GAP /kinetics/chain/kinetics[15]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[15]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[15]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[14]/Ras/GAP*/diff /kinetics/chain/kinetics[15]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[15]/Ras/GAP*/diff /kinetics/chain/kinetics[15]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/GAP* /kinetics/chain/kinetics[15]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/GAP* /kinetics/chain/kinetics[15]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ras/dephosph-GAP /kinetics/chain/kinetics[15]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[15]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[15]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[15]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[15]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[14]/Ras/GAP/diff /kinetics/chain/kinetics[15]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[15]/Ras/GAP/diff /kinetics/chain/kinetics[15]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/GTP-Ras /kinetics/chain/kinetics[15]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/GAP /kinetics/chain/kinetics[15]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[15]/Ras/GAP /kinetics/chain/kinetics[15]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/GAP /kinetics/chain/kinetics[15]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF /kinetics/chain/kinetics[15]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/CaM-GEF /kinetics/chain/kinetics[15]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca4 /kinetics/chain/kinetics[15]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[15]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[15]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[15]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[14]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[15]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[15]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[15]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[15]/Ras/GDP-Ras /kinetics/chain/kinetics[15]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ras/CaM-GEF /kinetics/chain/kinetics[15]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[15]/Ras/CaM-GEF /kinetics/chain/kinetics[15]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/CaM-GEF /kinetics/chain/kinetics[15]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[15]/Ca REAC A B addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[15]/Ca REAC A B addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[15]/Ca REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[15]/Ca REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[15]/Ca REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[15]/Ca REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[15]/Ca REAC A B addmsg /kinetics/chain/kinetics[15]/Ca_diff /kinetics/chain/kinetics[15]/Ca REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[15]/DAG REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG /kinetics/chain/kinetics[15]/DAG REAC A B addmsg /kinetics/chain/kinetics[15]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[15]/DAG REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[15]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[15]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[15]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[15]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[15]/PKC/PKC-basal* /kinetics/chain/kinetics[15]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[15]/PKC/PKC-AA* /kinetics/chain/kinetics[15]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[15]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[15]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[15]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[15]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[15]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[15]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[15]/PKC-active/phosph-AC2 /kinetics/chain/kinetics[15]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1 /kinetics/chain/kinetics[15]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC-active /kinetics/chain/kinetics[15]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[15]/Ras/GAP /kinetics/chain/kinetics[15]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC-active /kinetics/chain/kinetics[15]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF /kinetics/chain/kinetics[15]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PKC-active /kinetics/chain/kinetics[15]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[15]/PKC-active /kinetics/chain/kinetics[15]/PKC-active/phosph-AC2 ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[15]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MAPK*/MAPK* /kinetics/chain/kinetics[15]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[15]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[15]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[15]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[15]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[14]/MAPK*/diff /kinetics/chain/kinetics[15]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[15]/MAPK*/diff /kinetics/chain/kinetics[15]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[15]/MAPK*/MAPK* SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK* /kinetics/chain/kinetics[15]/MAPK*/MAPK* ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1* /kinetics/chain/kinetics[15]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK* /kinetics/chain/kinetics[15]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK* /kinetics/chain/kinetics[15]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK* /kinetics/chain/kinetics[15]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[15]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[15]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[15]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[14]/MKP-1/diff /kinetics/chain/kinetics[15]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[15]/MKP-1/diff /kinetics/chain/kinetics[15]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr /kinetics/chain/kinetics[15]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MKP-1 /kinetics/chain/kinetics[15]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK* /kinetics/chain/kinetics[15]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MKP-1 /kinetics/chain/kinetics[15]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[15]/MKP-1 /kinetics/chain/kinetics[15]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MKP-1 /kinetics/chain/kinetics[15]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[15]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[15]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[15]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[15]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[14]/PPhosphatase2A/diff /kinetics/chain/kinetics[15]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/diff /kinetics/chain/kinetics[15]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1* /kinetics/chain/kinetics[15]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A /kinetics/chain/kinetics[15]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK* /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1** /kinetics/chain/kinetics[15]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A /kinetics/chain/kinetics[15]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A /kinetics/chain/kinetics[15]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A /kinetics/chain/kinetics[15]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[15]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM/diff /kinetics/chain/kinetics[15]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[15]/CaM/CaM/diff /kinetics/chain/kinetics[15]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM /kinetics/chain/kinetics[15]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM /kinetics/chain/kinetics[15]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ca /kinetics/chain/kinetics[15]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ca /kinetics/chain/kinetics[15]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM /kinetics/chain/kinetics[15]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[15]/CaM/CaM-TR2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ca /kinetics/chain/kinetics[15]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca3 /kinetics/chain/kinetics[15]/CaM/CaM-TR2-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[15]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca3 /kinetics/chain/kinetics[15]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca4 /kinetics/chain/kinetics[15]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[15]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[15]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca3 /kinetics/chain/kinetics[15]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca3 /kinetics/chain/kinetics[15]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[15]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[15]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[15]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[14]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[15]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[15]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[15]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[15]/CaM/CaM-TR2-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[15]/CaM/CaM-TR2-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[15]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[15]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[14]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[15]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[15]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca4 /kinetics/chain/kinetics[15]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca4 /kinetics/chain/kinetics[15]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/MAPK/craf-1 /kinetics/chain/kinetics[15]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[15]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ras/GTP-Ras /kinetics/chain/kinetics[15]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[15]/Ca_diff /kinetics/chain/kinetics[15]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[15]/Ca /kinetics/chain/kinetics[15]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[15]/Ca_input /kinetics/chain/kinetics[15]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[16]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[16]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[16]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[16]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[16]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[16]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca /kinetics/chain/kinetics[16]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca /kinetics/chain/kinetics[16]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ca /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca /kinetics/chain/kinetics[16]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[16]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[16]/DAG /kinetics/chain/kinetics[16]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca /kinetics/chain/kinetics[16]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[16]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[16]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[16]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca-AA PRODUCT n addmsg /kinetics/chain/kinetics[16]/AA /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[16]/PKC/PKC-act-by-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[16]/PKC/PKC-act-by-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[16]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[16]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[16]/PKC/PKC-DAG-AA* REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[16]/PKC/PKC-DAG-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[16]/PKC/PKC-DAG-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[16]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[16]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[16]/PKC/PKC-Ca-AA* REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[16]/PKC/PKC-Ca-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[16]/PKC/PKC-Ca-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-basal-act /kinetics/chain/kinetics[16]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[16]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[16]/PKC/PKC-basal* REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-basal* /kinetics/chain/kinetics[16]/PKC/PKC-basal*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-basal* /kinetics/chain/kinetics[16]/PKC/PKC-basal*/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-basal* /kinetics/chain/kinetics[16]/PKC/PKC-basal-act PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic /kinetics/chain/kinetics[16]/PKC/PKC-basal-act SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[16]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[16]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[16]/PKC/PKC-AA* REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-AA* /kinetics/chain/kinetics[16]/PKC/PKC-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-AA* /kinetics/chain/kinetics[16]/PKC/PKC-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-AA* /kinetics/chain/kinetics[16]/PKC/PKC-act-by-AA PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic /kinetics/chain/kinetics[16]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/AA /kinetics/chain/kinetics[16]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/DAG /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG /kinetics/chain/kinetics[16]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[16]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[16]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[16]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG /kinetics/chain/kinetics[16]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG /kinetics/chain/kinetics[16]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[16]/AA /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[16]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[16]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[15]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[16]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[16]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[16]/PKC/PKC-DAG-AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[16]/PKC/PKC-DAG-AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-basal-act /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[16]/AA REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[16]/AA REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[16]/AA REAC A B addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[16]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[16]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[16]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[16]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[16]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[16]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[16]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[16]/PLA2/Degrade-AA /kinetics/chain/kinetics[16]/AA REAC A B addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[16]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[15]/AA/diff /kinetics/chain/kinetics[16]/AA REAC B A addmsg /kinetics/chain/kinetics[16]/AA/diff /kinetics/chain/kinetics[16]/AA REAC A B addmsg /kinetics/chain/kinetics[16]/AA /kinetics/chain/kinetics[16]/AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/AA /kinetics/chain/kinetics[16]/AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[16]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[16]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[16]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[16]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[16]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[16]/MAPK*/MAPK* /kinetics/chain/kinetics[16]/PLA2/PLA2-cytosolic REAC sA B addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[16]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[16]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[16]/PLA2/PLA2-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[16]/PLA2/PLA2-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ca /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca* REAC eA B addmsg /kinetics/chain/kinetics[16]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[16]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca*/kenz ENZYME n addmsg /kinetics/chain/kinetics[16]/PLA2/APC /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca*/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[16]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[16]/PLA2/PIP2-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[16]/temp-PIP2 /kinetics/chain/kinetics[16]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[16]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[16]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[16]/PLA2/PIP2-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[15]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[16]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[16]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[16]/PLA2/PIP2-PLA2* REAC A B addmsg /kinetics/chain/kinetics[16]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[16]/PLA2/PIP2-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[16]/PLA2/APC /kinetics/chain/kinetics[16]/PLA2/PIP2-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[16]/PLA2/PIP2-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[16]/PLA2/PIP2-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[16]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[16]/PLA2/PIP2-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[16]/temp-PIP2 /kinetics/chain/kinetics[16]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[16]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[16]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[16]/PLA2/PIP2-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[15]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[16]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[16]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[16]/PLA2/PIP2-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[16]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[16]/PLA2/PIP2-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[16]/PLA2/APC /kinetics/chain/kinetics[16]/PLA2/PIP2-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[16]/PLA2/PIP2-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[16]/PLA2/PIP2-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[16]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[16]/PLA2/DAG-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[16]/DAG /kinetics/chain/kinetics[16]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[16]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[16]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[16]/PLA2/DAG-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[15]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[16]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[16]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[16]/PLA2/DAG-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[16]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[16]/PLA2/DAG-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[16]/PLA2/APC /kinetics/chain/kinetics[16]/PLA2/DAG-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[16]/PLA2/DAG-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[16]/PLA2/DAG-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[16]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[16]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[16]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[16]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[16]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[16]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[16]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[16]/PLA2/Degrade-AA /kinetics/chain/kinetics[16]/PLA2/APC REAC B A addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[16]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[16]/AA /kinetics/chain/kinetics[16]/PLA2/Degrade-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PLA2/APC /kinetics/chain/kinetics[16]/PLA2/Degrade-AA PRODUCT n addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca REAC eA B addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca REAC A B addmsg /kinetics/chain/kinetics[16]/PLA2/APC /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca/kenz ENZYME n addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[16]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[16]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[16]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[16]/MAPK*/MAPK* /kinetics/chain/kinetics[16]/PLA2/PLA2* MM_PRD pA addmsg /kinetics/chain/kinetics[15]/PLA2/PLA2*/diff /kinetics/chain/kinetics[16]/PLA2/PLA2* REAC B A addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2*/diff /kinetics/chain/kinetics[16]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2* /kinetics/chain/kinetics[16]/PLA2/PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2* /kinetics/chain/kinetics[16]/PLA2/PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2* /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ca /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[16]/PLA2/dephosphorylate-PLA2* PRODUCT n addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2* /kinetics/chain/kinetics[16]/PLA2/dephosphorylate-PLA2* SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[16]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[16]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[16]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[16]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[16]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[16]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[16]/Ras-act-unphosph-raf /kinetics/chain/kinetics[16]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[16]/Ras-act-craf /kinetics/chain/kinetics[16]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[16]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[16]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[16]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[16]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[16]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[16]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[16]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[16]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[16]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[16]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[16]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK/diff /kinetics/chain/kinetics[16]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK/diff /kinetics/chain/kinetics[16]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK /kinetics/chain/kinetics[16]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK /kinetics/chain/kinetics[16]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[16]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[16]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[16]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[16]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[16]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[16]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[16]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[16]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[16]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK* /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK* /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[16]/Ras-act-unphosph-raf /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[16]/Ras-act-craf /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1* /kinetics/chain/kinetics[16]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[16]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ras/GTP-Ras /kinetics/chain/kinetics[16]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF /kinetics/chain/kinetics[16]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ras/GEF* /kinetics/chain/kinetics[16]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/dephosph-GEF /kinetics/chain/kinetics[16]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[16]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[16]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[16]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[16]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[16]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[15]/Ras/inact-GEF/diff /kinetics/chain/kinetics[16]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF/diff /kinetics/chain/kinetics[16]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF /kinetics/chain/kinetics[16]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[16]/Ras/GDP-Ras /kinetics/chain/kinetics[16]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF /kinetics/chain/kinetics[16]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF /kinetics/chain/kinetics[16]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ras/dephosph-GEF /kinetics/chain/kinetics[16]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[16]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[16]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[16]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[15]/Ras/GEF*/diff /kinetics/chain/kinetics[16]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[16]/Ras/GEF*/diff /kinetics/chain/kinetics[16]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/GEF* /kinetics/chain/kinetics[16]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[16]/Ras/GDP-Ras /kinetics/chain/kinetics[16]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/GEF* /kinetics/chain/kinetics[16]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/GEF* /kinetics/chain/kinetics[16]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ras-act-craf /kinetics/chain/kinetics[16]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[16]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[16]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[16]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[16]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[16]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[16]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[16]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[16]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[16]/Ras-act-unphosph-raf /kinetics/chain/kinetics[16]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[16]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[16]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[16]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[16]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[16]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[16]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[16]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[16]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[16]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[16]/Ras/GTP-Ras /kinetics/chain/kinetics[16]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/GDP-Ras /kinetics/chain/kinetics[16]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ras/GAP* /kinetics/chain/kinetics[16]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/GAP /kinetics/chain/kinetics[16]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ras/dephosph-GAP /kinetics/chain/kinetics[16]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[16]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[16]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[15]/Ras/GAP*/diff /kinetics/chain/kinetics[16]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[16]/Ras/GAP*/diff /kinetics/chain/kinetics[16]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/GAP* /kinetics/chain/kinetics[16]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/GAP* /kinetics/chain/kinetics[16]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ras/dephosph-GAP /kinetics/chain/kinetics[16]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[16]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[16]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[16]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[16]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[15]/Ras/GAP/diff /kinetics/chain/kinetics[16]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[16]/Ras/GAP/diff /kinetics/chain/kinetics[16]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/GTP-Ras /kinetics/chain/kinetics[16]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/GAP /kinetics/chain/kinetics[16]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[16]/Ras/GAP /kinetics/chain/kinetics[16]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/GAP /kinetics/chain/kinetics[16]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF /kinetics/chain/kinetics[16]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/CaM-GEF /kinetics/chain/kinetics[16]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca4 /kinetics/chain/kinetics[16]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[16]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[16]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[16]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[15]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[16]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[16]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[16]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[16]/Ras/GDP-Ras /kinetics/chain/kinetics[16]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ras/CaM-GEF /kinetics/chain/kinetics[16]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[16]/Ras/CaM-GEF /kinetics/chain/kinetics[16]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/CaM-GEF /kinetics/chain/kinetics[16]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[16]/Ca REAC A B addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[16]/Ca REAC A B addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[16]/Ca REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[16]/Ca REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[16]/Ca REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[16]/Ca REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[16]/Ca REAC A B addmsg /kinetics/chain/kinetics[16]/Ca_diff /kinetics/chain/kinetics[16]/Ca REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[16]/DAG REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG /kinetics/chain/kinetics[16]/DAG REAC A B addmsg /kinetics/chain/kinetics[16]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[16]/DAG REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[16]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[16]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[16]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[16]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[16]/PKC/PKC-basal* /kinetics/chain/kinetics[16]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[16]/PKC/PKC-AA* /kinetics/chain/kinetics[16]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[16]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[16]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[16]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[16]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[16]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[16]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[16]/PKC-active/phosph-AC2 /kinetics/chain/kinetics[16]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1 /kinetics/chain/kinetics[16]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC-active /kinetics/chain/kinetics[16]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[16]/Ras/GAP /kinetics/chain/kinetics[16]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC-active /kinetics/chain/kinetics[16]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF /kinetics/chain/kinetics[16]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PKC-active /kinetics/chain/kinetics[16]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[16]/PKC-active /kinetics/chain/kinetics[16]/PKC-active/phosph-AC2 ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[16]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MAPK*/MAPK* /kinetics/chain/kinetics[16]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[16]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[16]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[16]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[16]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[15]/MAPK*/diff /kinetics/chain/kinetics[16]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[16]/MAPK*/diff /kinetics/chain/kinetics[16]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[16]/MAPK*/MAPK* SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK* /kinetics/chain/kinetics[16]/MAPK*/MAPK* ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1* /kinetics/chain/kinetics[16]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK* /kinetics/chain/kinetics[16]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK* /kinetics/chain/kinetics[16]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK* /kinetics/chain/kinetics[16]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[16]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[16]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[16]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[15]/MKP-1/diff /kinetics/chain/kinetics[16]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[16]/MKP-1/diff /kinetics/chain/kinetics[16]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr /kinetics/chain/kinetics[16]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MKP-1 /kinetics/chain/kinetics[16]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK* /kinetics/chain/kinetics[16]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MKP-1 /kinetics/chain/kinetics[16]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[16]/MKP-1 /kinetics/chain/kinetics[16]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MKP-1 /kinetics/chain/kinetics[16]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[16]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[16]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[16]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[16]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[15]/PPhosphatase2A/diff /kinetics/chain/kinetics[16]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/diff /kinetics/chain/kinetics[16]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1* /kinetics/chain/kinetics[16]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A /kinetics/chain/kinetics[16]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK* /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1** /kinetics/chain/kinetics[16]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A /kinetics/chain/kinetics[16]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A /kinetics/chain/kinetics[16]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A /kinetics/chain/kinetics[16]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[16]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM/diff /kinetics/chain/kinetics[16]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[16]/CaM/CaM/diff /kinetics/chain/kinetics[16]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM /kinetics/chain/kinetics[16]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM /kinetics/chain/kinetics[16]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ca /kinetics/chain/kinetics[16]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ca /kinetics/chain/kinetics[16]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM /kinetics/chain/kinetics[16]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[16]/CaM/CaM-TR2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ca /kinetics/chain/kinetics[16]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca3 /kinetics/chain/kinetics[16]/CaM/CaM-TR2-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[16]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca3 /kinetics/chain/kinetics[16]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca4 /kinetics/chain/kinetics[16]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[16]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[16]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca3 /kinetics/chain/kinetics[16]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca3 /kinetics/chain/kinetics[16]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[16]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[16]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[16]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[15]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[16]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[16]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[16]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[16]/CaM/CaM-TR2-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[16]/CaM/CaM-TR2-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[16]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[16]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[15]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[16]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[16]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca4 /kinetics/chain/kinetics[16]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 /kinetics/chain/kinetics[16]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/MAPK/craf-1 /kinetics/chain/kinetics[16]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[16]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ras/GTP-Ras /kinetics/chain/kinetics[16]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[16]/Ca_diff /kinetics/chain/kinetics[16]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[16]/Ca /kinetics/chain/kinetics[16]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[16]/Ca_input /kinetics/chain/kinetics[16]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[17]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[17]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[17]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[17]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[17]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[17]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca /kinetics/chain/kinetics[17]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca /kinetics/chain/kinetics[17]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ca /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca /kinetics/chain/kinetics[17]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[17]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[17]/DAG /kinetics/chain/kinetics[17]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca /kinetics/chain/kinetics[17]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[17]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[17]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[17]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca-AA PRODUCT n addmsg /kinetics/chain/kinetics[17]/AA /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[17]/PKC/PKC-act-by-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[17]/PKC/PKC-act-by-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[17]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[17]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[17]/PKC/PKC-DAG-AA* REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[17]/PKC/PKC-DAG-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[17]/PKC/PKC-DAG-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[17]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[17]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[17]/PKC/PKC-Ca-AA* REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[17]/PKC/PKC-Ca-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[17]/PKC/PKC-Ca-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-basal-act /kinetics/chain/kinetics[17]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[17]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[17]/PKC/PKC-basal* REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-basal* /kinetics/chain/kinetics[17]/PKC/PKC-basal*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-basal* /kinetics/chain/kinetics[17]/PKC/PKC-basal*/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-basal* /kinetics/chain/kinetics[17]/PKC/PKC-basal-act PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic /kinetics/chain/kinetics[17]/PKC/PKC-basal-act SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[17]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[17]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[17]/PKC/PKC-AA* REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-AA* /kinetics/chain/kinetics[17]/PKC/PKC-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-AA* /kinetics/chain/kinetics[17]/PKC/PKC-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-AA* /kinetics/chain/kinetics[17]/PKC/PKC-act-by-AA PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic /kinetics/chain/kinetics[17]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/AA /kinetics/chain/kinetics[17]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/DAG /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG /kinetics/chain/kinetics[17]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[17]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[17]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[17]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG /kinetics/chain/kinetics[17]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG /kinetics/chain/kinetics[17]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[17]/AA /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[17]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[17]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[16]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[17]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[17]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[17]/PKC/PKC-DAG-AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[17]/PKC/PKC-DAG-AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-basal-act /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[17]/AA REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[17]/AA REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[17]/AA REAC A B addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[17]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[17]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[17]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[17]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[17]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[17]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[17]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[17]/PLA2/Degrade-AA /kinetics/chain/kinetics[17]/AA REAC A B addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[17]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[16]/AA/diff /kinetics/chain/kinetics[17]/AA REAC B A addmsg /kinetics/chain/kinetics[17]/AA/diff /kinetics/chain/kinetics[17]/AA REAC A B addmsg /kinetics/chain/kinetics[17]/AA /kinetics/chain/kinetics[17]/AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/AA /kinetics/chain/kinetics[17]/AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[17]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[17]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[17]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[17]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[17]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[17]/MAPK*/MAPK* /kinetics/chain/kinetics[17]/PLA2/PLA2-cytosolic REAC sA B addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[17]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[17]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[17]/PLA2/PLA2-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[17]/PLA2/PLA2-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ca /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca* REAC eA B addmsg /kinetics/chain/kinetics[17]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[17]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca*/kenz ENZYME n addmsg /kinetics/chain/kinetics[17]/PLA2/APC /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca*/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[17]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[17]/PLA2/PIP2-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[17]/temp-PIP2 /kinetics/chain/kinetics[17]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[17]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[17]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[17]/PLA2/PIP2-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[16]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[17]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[17]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[17]/PLA2/PIP2-PLA2* REAC A B addmsg /kinetics/chain/kinetics[17]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[17]/PLA2/PIP2-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[17]/PLA2/APC /kinetics/chain/kinetics[17]/PLA2/PIP2-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[17]/PLA2/PIP2-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[17]/PLA2/PIP2-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[17]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[17]/PLA2/PIP2-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[17]/temp-PIP2 /kinetics/chain/kinetics[17]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[17]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[17]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[17]/PLA2/PIP2-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[16]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[17]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[17]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[17]/PLA2/PIP2-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[17]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[17]/PLA2/PIP2-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[17]/PLA2/APC /kinetics/chain/kinetics[17]/PLA2/PIP2-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[17]/PLA2/PIP2-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[17]/PLA2/PIP2-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[17]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[17]/PLA2/DAG-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[17]/DAG /kinetics/chain/kinetics[17]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[17]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[17]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[17]/PLA2/DAG-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[16]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[17]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[17]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[17]/PLA2/DAG-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[17]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[17]/PLA2/DAG-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[17]/PLA2/APC /kinetics/chain/kinetics[17]/PLA2/DAG-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[17]/PLA2/DAG-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[17]/PLA2/DAG-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[17]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[17]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[17]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[17]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[17]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[17]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[17]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[17]/PLA2/Degrade-AA /kinetics/chain/kinetics[17]/PLA2/APC REAC B A addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[17]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[17]/AA /kinetics/chain/kinetics[17]/PLA2/Degrade-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PLA2/APC /kinetics/chain/kinetics[17]/PLA2/Degrade-AA PRODUCT n addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca REAC eA B addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca REAC A B addmsg /kinetics/chain/kinetics[17]/PLA2/APC /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca/kenz ENZYME n addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[17]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[17]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[17]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[17]/MAPK*/MAPK* /kinetics/chain/kinetics[17]/PLA2/PLA2* MM_PRD pA addmsg /kinetics/chain/kinetics[16]/PLA2/PLA2*/diff /kinetics/chain/kinetics[17]/PLA2/PLA2* REAC B A addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2*/diff /kinetics/chain/kinetics[17]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2* /kinetics/chain/kinetics[17]/PLA2/PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2* /kinetics/chain/kinetics[17]/PLA2/PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2* /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ca /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[17]/PLA2/dephosphorylate-PLA2* PRODUCT n addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2* /kinetics/chain/kinetics[17]/PLA2/dephosphorylate-PLA2* SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[17]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[17]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[17]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[17]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[17]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[17]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[17]/Ras-act-unphosph-raf /kinetics/chain/kinetics[17]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[17]/Ras-act-craf /kinetics/chain/kinetics[17]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[17]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[17]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[17]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[17]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[17]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[17]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[17]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[17]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[17]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[17]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[17]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK/diff /kinetics/chain/kinetics[17]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK/diff /kinetics/chain/kinetics[17]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK /kinetics/chain/kinetics[17]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK /kinetics/chain/kinetics[17]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[17]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[17]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[17]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[17]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[17]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[17]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[17]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[17]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[17]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK* /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK* /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[17]/Ras-act-unphosph-raf /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[17]/Ras-act-craf /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1* /kinetics/chain/kinetics[17]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[17]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ras/GTP-Ras /kinetics/chain/kinetics[17]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF /kinetics/chain/kinetics[17]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ras/GEF* /kinetics/chain/kinetics[17]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/dephosph-GEF /kinetics/chain/kinetics[17]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[17]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[17]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[17]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[17]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[17]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[16]/Ras/inact-GEF/diff /kinetics/chain/kinetics[17]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF/diff /kinetics/chain/kinetics[17]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF /kinetics/chain/kinetics[17]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[17]/Ras/GDP-Ras /kinetics/chain/kinetics[17]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF /kinetics/chain/kinetics[17]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF /kinetics/chain/kinetics[17]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ras/dephosph-GEF /kinetics/chain/kinetics[17]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[17]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[17]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[17]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[16]/Ras/GEF*/diff /kinetics/chain/kinetics[17]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[17]/Ras/GEF*/diff /kinetics/chain/kinetics[17]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/GEF* /kinetics/chain/kinetics[17]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[17]/Ras/GDP-Ras /kinetics/chain/kinetics[17]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/GEF* /kinetics/chain/kinetics[17]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/GEF* /kinetics/chain/kinetics[17]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ras-act-craf /kinetics/chain/kinetics[17]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[17]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[17]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[17]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[17]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[17]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[17]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[17]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[17]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[17]/Ras-act-unphosph-raf /kinetics/chain/kinetics[17]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[17]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[17]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[17]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[17]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[17]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[17]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[17]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[17]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[17]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[17]/Ras/GTP-Ras /kinetics/chain/kinetics[17]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/GDP-Ras /kinetics/chain/kinetics[17]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ras/GAP* /kinetics/chain/kinetics[17]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/GAP /kinetics/chain/kinetics[17]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ras/dephosph-GAP /kinetics/chain/kinetics[17]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[17]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[17]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[16]/Ras/GAP*/diff /kinetics/chain/kinetics[17]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[17]/Ras/GAP*/diff /kinetics/chain/kinetics[17]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/GAP* /kinetics/chain/kinetics[17]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/GAP* /kinetics/chain/kinetics[17]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ras/dephosph-GAP /kinetics/chain/kinetics[17]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[17]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[17]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[17]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[17]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[16]/Ras/GAP/diff /kinetics/chain/kinetics[17]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[17]/Ras/GAP/diff /kinetics/chain/kinetics[17]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/GTP-Ras /kinetics/chain/kinetics[17]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/GAP /kinetics/chain/kinetics[17]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[17]/Ras/GAP /kinetics/chain/kinetics[17]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/GAP /kinetics/chain/kinetics[17]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF /kinetics/chain/kinetics[17]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/CaM-GEF /kinetics/chain/kinetics[17]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 /kinetics/chain/kinetics[17]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[17]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[17]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[17]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[16]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[17]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[17]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[17]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[17]/Ras/GDP-Ras /kinetics/chain/kinetics[17]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ras/CaM-GEF /kinetics/chain/kinetics[17]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[17]/Ras/CaM-GEF /kinetics/chain/kinetics[17]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/CaM-GEF /kinetics/chain/kinetics[17]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[17]/Ca REAC A B addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[17]/Ca REAC A B addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[17]/Ca REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[17]/Ca REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[17]/Ca REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[17]/Ca REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[17]/Ca REAC A B addmsg /kinetics/chain/kinetics[17]/Ca_diff /kinetics/chain/kinetics[17]/Ca REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[17]/DAG REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG /kinetics/chain/kinetics[17]/DAG REAC A B addmsg /kinetics/chain/kinetics[17]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[17]/DAG REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[17]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[17]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[17]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[17]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[17]/PKC/PKC-basal* /kinetics/chain/kinetics[17]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[17]/PKC/PKC-AA* /kinetics/chain/kinetics[17]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[17]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[17]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[17]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[17]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[17]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[17]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[17]/PKC-active/phosph-AC2 /kinetics/chain/kinetics[17]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1 /kinetics/chain/kinetics[17]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC-active /kinetics/chain/kinetics[17]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[17]/Ras/GAP /kinetics/chain/kinetics[17]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC-active /kinetics/chain/kinetics[17]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF /kinetics/chain/kinetics[17]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PKC-active /kinetics/chain/kinetics[17]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[17]/PKC-active /kinetics/chain/kinetics[17]/PKC-active/phosph-AC2 ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[17]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MAPK*/MAPK* /kinetics/chain/kinetics[17]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[17]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[17]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[17]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[17]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[16]/MAPK*/diff /kinetics/chain/kinetics[17]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[17]/MAPK*/diff /kinetics/chain/kinetics[17]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[17]/MAPK*/MAPK* SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK* /kinetics/chain/kinetics[17]/MAPK*/MAPK* ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1* /kinetics/chain/kinetics[17]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK* /kinetics/chain/kinetics[17]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK* /kinetics/chain/kinetics[17]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK* /kinetics/chain/kinetics[17]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[17]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[17]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[17]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[16]/MKP-1/diff /kinetics/chain/kinetics[17]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[17]/MKP-1/diff /kinetics/chain/kinetics[17]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr /kinetics/chain/kinetics[17]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MKP-1 /kinetics/chain/kinetics[17]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK* /kinetics/chain/kinetics[17]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MKP-1 /kinetics/chain/kinetics[17]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[17]/MKP-1 /kinetics/chain/kinetics[17]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MKP-1 /kinetics/chain/kinetics[17]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[17]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[17]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[17]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[17]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[16]/PPhosphatase2A/diff /kinetics/chain/kinetics[17]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/diff /kinetics/chain/kinetics[17]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1* /kinetics/chain/kinetics[17]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A /kinetics/chain/kinetics[17]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK* /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1** /kinetics/chain/kinetics[17]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A /kinetics/chain/kinetics[17]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A /kinetics/chain/kinetics[17]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A /kinetics/chain/kinetics[17]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[17]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM/diff /kinetics/chain/kinetics[17]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[17]/CaM/CaM/diff /kinetics/chain/kinetics[17]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM /kinetics/chain/kinetics[17]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM /kinetics/chain/kinetics[17]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ca /kinetics/chain/kinetics[17]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ca /kinetics/chain/kinetics[17]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM /kinetics/chain/kinetics[17]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[17]/CaM/CaM-TR2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ca /kinetics/chain/kinetics[17]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca3 /kinetics/chain/kinetics[17]/CaM/CaM-TR2-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[17]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca3 /kinetics/chain/kinetics[17]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 /kinetics/chain/kinetics[17]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[17]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[17]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca3 /kinetics/chain/kinetics[17]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca3 /kinetics/chain/kinetics[17]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[17]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[17]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[17]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[16]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[17]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[17]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[17]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[17]/CaM/CaM-TR2-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[17]/CaM/CaM-TR2-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[16]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca4 /kinetics/chain/kinetics[17]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca4 /kinetics/chain/kinetics[17]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/MAPK/craf-1 /kinetics/chain/kinetics[17]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[17]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ras/GTP-Ras /kinetics/chain/kinetics[17]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[17]/Ca_diff /kinetics/chain/kinetics[17]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[17]/Ca /kinetics/chain/kinetics[17]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[17]/Ca_input /kinetics/chain/kinetics[17]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[18]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[18]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[18]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[18]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[18]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[18]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca /kinetics/chain/kinetics[18]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca /kinetics/chain/kinetics[18]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ca /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca /kinetics/chain/kinetics[18]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[18]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[18]/DAG /kinetics/chain/kinetics[18]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca /kinetics/chain/kinetics[18]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[18]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[18]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[18]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca-AA PRODUCT n addmsg /kinetics/chain/kinetics[18]/AA /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[18]/PKC/PKC-act-by-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[18]/PKC/PKC-act-by-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[18]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[18]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[18]/PKC/PKC-DAG-AA* REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[18]/PKC/PKC-DAG-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[18]/PKC/PKC-DAG-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[18]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[18]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[18]/PKC/PKC-Ca-AA* REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[18]/PKC/PKC-Ca-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[18]/PKC/PKC-Ca-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-basal-act /kinetics/chain/kinetics[18]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[18]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[18]/PKC/PKC-basal* REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-basal* /kinetics/chain/kinetics[18]/PKC/PKC-basal*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-basal* /kinetics/chain/kinetics[18]/PKC/PKC-basal*/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-basal* /kinetics/chain/kinetics[18]/PKC/PKC-basal-act PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic /kinetics/chain/kinetics[18]/PKC/PKC-basal-act SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[18]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[18]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[18]/PKC/PKC-AA* REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-AA* /kinetics/chain/kinetics[18]/PKC/PKC-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-AA* /kinetics/chain/kinetics[18]/PKC/PKC-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-AA* /kinetics/chain/kinetics[18]/PKC/PKC-act-by-AA PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic /kinetics/chain/kinetics[18]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/AA /kinetics/chain/kinetics[18]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/DAG /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG /kinetics/chain/kinetics[18]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[18]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[18]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[18]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG /kinetics/chain/kinetics[18]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG /kinetics/chain/kinetics[18]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[18]/AA /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[18]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[18]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[17]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[18]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[18]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[18]/PKC/PKC-DAG-AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[18]/PKC/PKC-DAG-AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-basal-act /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[18]/AA REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[18]/AA REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[18]/AA REAC A B addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[18]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[18]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[18]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[18]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[18]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[18]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[18]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[18]/PLA2/Degrade-AA /kinetics/chain/kinetics[18]/AA REAC A B addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[18]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[17]/AA/diff /kinetics/chain/kinetics[18]/AA REAC B A addmsg /kinetics/chain/kinetics[18]/AA/diff /kinetics/chain/kinetics[18]/AA REAC A B addmsg /kinetics/chain/kinetics[18]/AA /kinetics/chain/kinetics[18]/AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/AA /kinetics/chain/kinetics[18]/AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[18]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[18]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[18]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[18]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[18]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[18]/MAPK*/MAPK* /kinetics/chain/kinetics[18]/PLA2/PLA2-cytosolic REAC sA B addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[18]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[18]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[18]/PLA2/PLA2-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[18]/PLA2/PLA2-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ca /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca* REAC eA B addmsg /kinetics/chain/kinetics[18]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[18]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca*/kenz ENZYME n addmsg /kinetics/chain/kinetics[18]/PLA2/APC /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca*/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[18]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[18]/PLA2/PIP2-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[18]/temp-PIP2 /kinetics/chain/kinetics[18]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[18]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[18]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[18]/PLA2/PIP2-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[17]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[18]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[18]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[18]/PLA2/PIP2-PLA2* REAC A B addmsg /kinetics/chain/kinetics[18]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[18]/PLA2/PIP2-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[18]/PLA2/APC /kinetics/chain/kinetics[18]/PLA2/PIP2-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[18]/PLA2/PIP2-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[18]/PLA2/PIP2-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[18]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[18]/PLA2/PIP2-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[18]/temp-PIP2 /kinetics/chain/kinetics[18]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[18]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[18]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[18]/PLA2/PIP2-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[17]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[18]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[18]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[18]/PLA2/PIP2-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[18]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[18]/PLA2/PIP2-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[18]/PLA2/APC /kinetics/chain/kinetics[18]/PLA2/PIP2-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[18]/PLA2/PIP2-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[18]/PLA2/PIP2-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[18]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[18]/PLA2/DAG-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[18]/DAG /kinetics/chain/kinetics[18]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[18]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[18]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[18]/PLA2/DAG-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[17]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[18]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[18]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[18]/PLA2/DAG-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[18]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[18]/PLA2/DAG-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[18]/PLA2/APC /kinetics/chain/kinetics[18]/PLA2/DAG-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[18]/PLA2/DAG-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[18]/PLA2/DAG-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[18]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[18]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[18]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[18]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[18]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[18]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[18]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[18]/PLA2/Degrade-AA /kinetics/chain/kinetics[18]/PLA2/APC REAC B A addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[18]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[18]/AA /kinetics/chain/kinetics[18]/PLA2/Degrade-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PLA2/APC /kinetics/chain/kinetics[18]/PLA2/Degrade-AA PRODUCT n addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca REAC eA B addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca REAC A B addmsg /kinetics/chain/kinetics[18]/PLA2/APC /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca/kenz ENZYME n addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[18]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[18]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[18]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[18]/MAPK*/MAPK* /kinetics/chain/kinetics[18]/PLA2/PLA2* MM_PRD pA addmsg /kinetics/chain/kinetics[17]/PLA2/PLA2*/diff /kinetics/chain/kinetics[18]/PLA2/PLA2* REAC B A addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2*/diff /kinetics/chain/kinetics[18]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2* /kinetics/chain/kinetics[18]/PLA2/PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2* /kinetics/chain/kinetics[18]/PLA2/PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2* /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ca /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[18]/PLA2/dephosphorylate-PLA2* PRODUCT n addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2* /kinetics/chain/kinetics[18]/PLA2/dephosphorylate-PLA2* SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[18]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[18]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[18]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[18]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[18]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[18]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[18]/Ras-act-unphosph-raf /kinetics/chain/kinetics[18]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[18]/Ras-act-craf /kinetics/chain/kinetics[18]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[18]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[18]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[18]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[18]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[18]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[18]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[18]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[18]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[18]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[18]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[18]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK/diff /kinetics/chain/kinetics[18]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK/diff /kinetics/chain/kinetics[18]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK /kinetics/chain/kinetics[18]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK /kinetics/chain/kinetics[18]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[18]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[18]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[18]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[18]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[18]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[18]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[18]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[18]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[18]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK* /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK* /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[18]/Ras-act-unphosph-raf /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[18]/Ras-act-craf /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1* /kinetics/chain/kinetics[18]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[18]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ras/GTP-Ras /kinetics/chain/kinetics[18]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF /kinetics/chain/kinetics[18]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ras/GEF* /kinetics/chain/kinetics[18]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/dephosph-GEF /kinetics/chain/kinetics[18]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[18]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[18]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[18]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[18]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[18]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[17]/Ras/inact-GEF/diff /kinetics/chain/kinetics[18]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF/diff /kinetics/chain/kinetics[18]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF /kinetics/chain/kinetics[18]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[18]/Ras/GDP-Ras /kinetics/chain/kinetics[18]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF /kinetics/chain/kinetics[18]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF /kinetics/chain/kinetics[18]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ras/dephosph-GEF /kinetics/chain/kinetics[18]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[18]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[18]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[18]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[17]/Ras/GEF*/diff /kinetics/chain/kinetics[18]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[18]/Ras/GEF*/diff /kinetics/chain/kinetics[18]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/GEF* /kinetics/chain/kinetics[18]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[18]/Ras/GDP-Ras /kinetics/chain/kinetics[18]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/GEF* /kinetics/chain/kinetics[18]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/GEF* /kinetics/chain/kinetics[18]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ras-act-craf /kinetics/chain/kinetics[18]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[18]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[18]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[18]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[18]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[18]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[18]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[18]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[18]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[18]/Ras-act-unphosph-raf /kinetics/chain/kinetics[18]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[18]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[18]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[18]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[18]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[18]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[18]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[18]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[18]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[18]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[18]/Ras/GTP-Ras /kinetics/chain/kinetics[18]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/GDP-Ras /kinetics/chain/kinetics[18]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ras/GAP* /kinetics/chain/kinetics[18]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/GAP /kinetics/chain/kinetics[18]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ras/dephosph-GAP /kinetics/chain/kinetics[18]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[18]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[18]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[17]/Ras/GAP*/diff /kinetics/chain/kinetics[18]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[18]/Ras/GAP*/diff /kinetics/chain/kinetics[18]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/GAP* /kinetics/chain/kinetics[18]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/GAP* /kinetics/chain/kinetics[18]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ras/dephosph-GAP /kinetics/chain/kinetics[18]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[18]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[18]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[18]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[18]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[17]/Ras/GAP/diff /kinetics/chain/kinetics[18]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[18]/Ras/GAP/diff /kinetics/chain/kinetics[18]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/GTP-Ras /kinetics/chain/kinetics[18]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/GAP /kinetics/chain/kinetics[18]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[18]/Ras/GAP /kinetics/chain/kinetics[18]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/GAP /kinetics/chain/kinetics[18]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF /kinetics/chain/kinetics[18]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/CaM-GEF /kinetics/chain/kinetics[18]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca4 /kinetics/chain/kinetics[18]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[18]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[18]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[18]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[17]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[18]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[18]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[18]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[18]/Ras/GDP-Ras /kinetics/chain/kinetics[18]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ras/CaM-GEF /kinetics/chain/kinetics[18]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[18]/Ras/CaM-GEF /kinetics/chain/kinetics[18]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/CaM-GEF /kinetics/chain/kinetics[18]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[18]/Ca REAC A B addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[18]/Ca REAC A B addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[18]/Ca REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[18]/Ca REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[18]/Ca REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[18]/Ca REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[18]/Ca REAC A B addmsg /kinetics/chain/kinetics[18]/Ca_diff /kinetics/chain/kinetics[18]/Ca REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[18]/DAG REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG /kinetics/chain/kinetics[18]/DAG REAC A B addmsg /kinetics/chain/kinetics[18]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[18]/DAG REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[18]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[18]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[18]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[18]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[18]/PKC/PKC-basal* /kinetics/chain/kinetics[18]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[18]/PKC/PKC-AA* /kinetics/chain/kinetics[18]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[18]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[18]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[18]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[18]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[18]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[18]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[18]/PKC-active/phosph-AC2 /kinetics/chain/kinetics[18]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1 /kinetics/chain/kinetics[18]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC-active /kinetics/chain/kinetics[18]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[18]/Ras/GAP /kinetics/chain/kinetics[18]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC-active /kinetics/chain/kinetics[18]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF /kinetics/chain/kinetics[18]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PKC-active /kinetics/chain/kinetics[18]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[18]/PKC-active /kinetics/chain/kinetics[18]/PKC-active/phosph-AC2 ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[18]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MAPK*/MAPK* /kinetics/chain/kinetics[18]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[18]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[18]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[18]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[18]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[17]/MAPK*/diff /kinetics/chain/kinetics[18]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[18]/MAPK*/diff /kinetics/chain/kinetics[18]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[18]/MAPK*/MAPK* SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK* /kinetics/chain/kinetics[18]/MAPK*/MAPK* ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1* /kinetics/chain/kinetics[18]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK* /kinetics/chain/kinetics[18]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK* /kinetics/chain/kinetics[18]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK* /kinetics/chain/kinetics[18]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[18]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[18]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[18]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[17]/MKP-1/diff /kinetics/chain/kinetics[18]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[18]/MKP-1/diff /kinetics/chain/kinetics[18]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr /kinetics/chain/kinetics[18]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MKP-1 /kinetics/chain/kinetics[18]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK* /kinetics/chain/kinetics[18]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MKP-1 /kinetics/chain/kinetics[18]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[18]/MKP-1 /kinetics/chain/kinetics[18]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MKP-1 /kinetics/chain/kinetics[18]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[18]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[18]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[18]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[18]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[17]/PPhosphatase2A/diff /kinetics/chain/kinetics[18]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/diff /kinetics/chain/kinetics[18]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1* /kinetics/chain/kinetics[18]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A /kinetics/chain/kinetics[18]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK* /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1** /kinetics/chain/kinetics[18]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A /kinetics/chain/kinetics[18]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A /kinetics/chain/kinetics[18]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A /kinetics/chain/kinetics[18]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[18]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM/diff /kinetics/chain/kinetics[18]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[18]/CaM/CaM/diff /kinetics/chain/kinetics[18]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM /kinetics/chain/kinetics[18]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM /kinetics/chain/kinetics[18]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ca /kinetics/chain/kinetics[18]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ca /kinetics/chain/kinetics[18]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM /kinetics/chain/kinetics[18]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[18]/CaM/CaM-TR2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ca /kinetics/chain/kinetics[18]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca3 /kinetics/chain/kinetics[18]/CaM/CaM-TR2-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[18]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca3 /kinetics/chain/kinetics[18]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca4 /kinetics/chain/kinetics[18]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[18]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[18]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca3 /kinetics/chain/kinetics[18]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca3 /kinetics/chain/kinetics[18]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[18]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[18]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[18]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[17]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[18]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[18]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[18]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[18]/CaM/CaM-TR2-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[18]/CaM/CaM-TR2-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[18]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[18]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[17]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[18]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[18]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca4 /kinetics/chain/kinetics[18]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 /kinetics/chain/kinetics[18]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/MAPK/craf-1 /kinetics/chain/kinetics[18]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[18]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ras/GTP-Ras /kinetics/chain/kinetics[18]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[18]/Ca_diff /kinetics/chain/kinetics[18]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[18]/Ca /kinetics/chain/kinetics[18]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[18]/Ca_input /kinetics/chain/kinetics[18]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[19]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[19]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[19]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[19]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[19]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[19]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca /kinetics/chain/kinetics[19]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca /kinetics/chain/kinetics[19]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ca /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca /kinetics/chain/kinetics[19]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[19]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[19]/DAG /kinetics/chain/kinetics[19]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca /kinetics/chain/kinetics[19]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[19]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[19]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[19]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca-AA PRODUCT n addmsg /kinetics/chain/kinetics[19]/AA /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[19]/PKC/PKC-act-by-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[19]/PKC/PKC-act-by-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[19]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[19]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[19]/PKC/PKC-DAG-AA* REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[19]/PKC/PKC-DAG-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[19]/PKC/PKC-DAG-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[19]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[19]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[19]/PKC/PKC-Ca-AA* REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[19]/PKC/PKC-Ca-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[19]/PKC/PKC-Ca-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-basal-act /kinetics/chain/kinetics[19]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[19]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[19]/PKC/PKC-basal* REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-basal* /kinetics/chain/kinetics[19]/PKC/PKC-basal*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-basal* /kinetics/chain/kinetics[19]/PKC/PKC-basal*/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-basal* /kinetics/chain/kinetics[19]/PKC/PKC-basal-act PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic /kinetics/chain/kinetics[19]/PKC/PKC-basal-act SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[19]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[19]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[19]/PKC/PKC-AA* REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-AA* /kinetics/chain/kinetics[19]/PKC/PKC-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-AA* /kinetics/chain/kinetics[19]/PKC/PKC-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-AA* /kinetics/chain/kinetics[19]/PKC/PKC-act-by-AA PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic /kinetics/chain/kinetics[19]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/AA /kinetics/chain/kinetics[19]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/DAG /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG /kinetics/chain/kinetics[19]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[19]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[19]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[19]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG /kinetics/chain/kinetics[19]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG /kinetics/chain/kinetics[19]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[19]/AA /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[19]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[19]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[18]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[19]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[19]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[19]/PKC/PKC-DAG-AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[19]/PKC/PKC-DAG-AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-basal-act /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[19]/AA REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[19]/AA REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[19]/AA REAC A B addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[19]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[19]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[19]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[19]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[19]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[19]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[19]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[19]/PLA2/Degrade-AA /kinetics/chain/kinetics[19]/AA REAC A B addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[19]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[18]/AA/diff /kinetics/chain/kinetics[19]/AA REAC B A addmsg /kinetics/chain/kinetics[19]/AA/diff /kinetics/chain/kinetics[19]/AA REAC A B addmsg /kinetics/chain/kinetics[19]/AA /kinetics/chain/kinetics[19]/AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/AA /kinetics/chain/kinetics[19]/AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[19]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[19]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[19]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[19]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[19]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[19]/MAPK*/MAPK* /kinetics/chain/kinetics[19]/PLA2/PLA2-cytosolic REAC sA B addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[19]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[19]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[19]/PLA2/PLA2-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[19]/PLA2/PLA2-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ca /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca* REAC eA B addmsg /kinetics/chain/kinetics[19]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[19]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca*/kenz ENZYME n addmsg /kinetics/chain/kinetics[19]/PLA2/APC /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca*/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[19]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[19]/PLA2/PIP2-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[19]/temp-PIP2 /kinetics/chain/kinetics[19]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[19]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[19]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[19]/PLA2/PIP2-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[18]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[19]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[19]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[19]/PLA2/PIP2-PLA2* REAC A B addmsg /kinetics/chain/kinetics[19]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[19]/PLA2/PIP2-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[19]/PLA2/APC /kinetics/chain/kinetics[19]/PLA2/PIP2-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[19]/PLA2/PIP2-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[19]/PLA2/PIP2-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[19]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[19]/PLA2/PIP2-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[19]/temp-PIP2 /kinetics/chain/kinetics[19]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[19]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[19]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[19]/PLA2/PIP2-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[18]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[19]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[19]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[19]/PLA2/PIP2-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[19]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[19]/PLA2/PIP2-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[19]/PLA2/APC /kinetics/chain/kinetics[19]/PLA2/PIP2-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[19]/PLA2/PIP2-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[19]/PLA2/PIP2-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[19]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[19]/PLA2/DAG-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[19]/DAG /kinetics/chain/kinetics[19]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[19]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[19]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[19]/PLA2/DAG-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[18]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[19]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[19]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[19]/PLA2/DAG-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[19]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[19]/PLA2/DAG-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[19]/PLA2/APC /kinetics/chain/kinetics[19]/PLA2/DAG-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[19]/PLA2/DAG-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[19]/PLA2/DAG-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[19]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[19]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[19]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[19]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[19]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[19]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[19]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[19]/PLA2/Degrade-AA /kinetics/chain/kinetics[19]/PLA2/APC REAC B A addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[19]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[19]/AA /kinetics/chain/kinetics[19]/PLA2/Degrade-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PLA2/APC /kinetics/chain/kinetics[19]/PLA2/Degrade-AA PRODUCT n addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca REAC eA B addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca REAC A B addmsg /kinetics/chain/kinetics[19]/PLA2/APC /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca/kenz ENZYME n addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[19]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[19]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[19]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[19]/MAPK*/MAPK* /kinetics/chain/kinetics[19]/PLA2/PLA2* MM_PRD pA addmsg /kinetics/chain/kinetics[18]/PLA2/PLA2*/diff /kinetics/chain/kinetics[19]/PLA2/PLA2* REAC B A addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2*/diff /kinetics/chain/kinetics[19]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2* /kinetics/chain/kinetics[19]/PLA2/PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2* /kinetics/chain/kinetics[19]/PLA2/PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2* /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ca /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[19]/PLA2/dephosphorylate-PLA2* PRODUCT n addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2* /kinetics/chain/kinetics[19]/PLA2/dephosphorylate-PLA2* SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[19]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[19]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[19]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[19]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[19]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[19]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[19]/Ras-act-unphosph-raf /kinetics/chain/kinetics[19]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[19]/Ras-act-craf /kinetics/chain/kinetics[19]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[19]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[19]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[19]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[19]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[19]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[19]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[19]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[19]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[19]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[19]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[19]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK/diff /kinetics/chain/kinetics[19]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK/diff /kinetics/chain/kinetics[19]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK /kinetics/chain/kinetics[19]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK /kinetics/chain/kinetics[19]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[19]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[19]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[19]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[19]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[19]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[19]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[19]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[19]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[19]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK* /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK* /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[19]/Ras-act-unphosph-raf /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[19]/Ras-act-craf /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1* /kinetics/chain/kinetics[19]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[19]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ras/GTP-Ras /kinetics/chain/kinetics[19]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF /kinetics/chain/kinetics[19]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ras/GEF* /kinetics/chain/kinetics[19]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/dephosph-GEF /kinetics/chain/kinetics[19]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[19]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[19]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[19]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[19]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[19]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[18]/Ras/inact-GEF/diff /kinetics/chain/kinetics[19]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF/diff /kinetics/chain/kinetics[19]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF /kinetics/chain/kinetics[19]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[19]/Ras/GDP-Ras /kinetics/chain/kinetics[19]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF /kinetics/chain/kinetics[19]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF /kinetics/chain/kinetics[19]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ras/dephosph-GEF /kinetics/chain/kinetics[19]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[19]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[19]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[19]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[18]/Ras/GEF*/diff /kinetics/chain/kinetics[19]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[19]/Ras/GEF*/diff /kinetics/chain/kinetics[19]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/GEF* /kinetics/chain/kinetics[19]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[19]/Ras/GDP-Ras /kinetics/chain/kinetics[19]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/GEF* /kinetics/chain/kinetics[19]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/GEF* /kinetics/chain/kinetics[19]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ras-act-craf /kinetics/chain/kinetics[19]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[19]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[19]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[19]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[19]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[19]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[19]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[19]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[19]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[19]/Ras-act-unphosph-raf /kinetics/chain/kinetics[19]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[19]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[19]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[19]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[19]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[19]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[19]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[19]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[19]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[19]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[19]/Ras/GTP-Ras /kinetics/chain/kinetics[19]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/GDP-Ras /kinetics/chain/kinetics[19]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ras/GAP* /kinetics/chain/kinetics[19]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/GAP /kinetics/chain/kinetics[19]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ras/dephosph-GAP /kinetics/chain/kinetics[19]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[19]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[19]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[18]/Ras/GAP*/diff /kinetics/chain/kinetics[19]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[19]/Ras/GAP*/diff /kinetics/chain/kinetics[19]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/GAP* /kinetics/chain/kinetics[19]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/GAP* /kinetics/chain/kinetics[19]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ras/dephosph-GAP /kinetics/chain/kinetics[19]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[19]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[19]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[19]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[19]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[18]/Ras/GAP/diff /kinetics/chain/kinetics[19]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[19]/Ras/GAP/diff /kinetics/chain/kinetics[19]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/GTP-Ras /kinetics/chain/kinetics[19]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/GAP /kinetics/chain/kinetics[19]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[19]/Ras/GAP /kinetics/chain/kinetics[19]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/GAP /kinetics/chain/kinetics[19]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF /kinetics/chain/kinetics[19]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/CaM-GEF /kinetics/chain/kinetics[19]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 /kinetics/chain/kinetics[19]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[19]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[19]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[19]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[18]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[19]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[19]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[19]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[19]/Ras/GDP-Ras /kinetics/chain/kinetics[19]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ras/CaM-GEF /kinetics/chain/kinetics[19]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[19]/Ras/CaM-GEF /kinetics/chain/kinetics[19]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/CaM-GEF /kinetics/chain/kinetics[19]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[19]/Ca REAC A B addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[19]/Ca REAC A B addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[19]/Ca REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[19]/Ca REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[19]/Ca REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[19]/Ca REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[19]/Ca REAC A B addmsg /kinetics/chain/kinetics[19]/Ca_diff /kinetics/chain/kinetics[19]/Ca REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[19]/DAG REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG /kinetics/chain/kinetics[19]/DAG REAC A B addmsg /kinetics/chain/kinetics[19]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[19]/DAG REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[19]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[19]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[19]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[19]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[19]/PKC/PKC-basal* /kinetics/chain/kinetics[19]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[19]/PKC/PKC-AA* /kinetics/chain/kinetics[19]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[19]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[19]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[19]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[19]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[19]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[19]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[19]/PKC-active/phosph-AC2 /kinetics/chain/kinetics[19]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1 /kinetics/chain/kinetics[19]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC-active /kinetics/chain/kinetics[19]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[19]/Ras/GAP /kinetics/chain/kinetics[19]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC-active /kinetics/chain/kinetics[19]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF /kinetics/chain/kinetics[19]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PKC-active /kinetics/chain/kinetics[19]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[19]/PKC-active /kinetics/chain/kinetics[19]/PKC-active/phosph-AC2 ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[19]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MAPK*/MAPK* /kinetics/chain/kinetics[19]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[19]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[19]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[19]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[19]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[18]/MAPK*/diff /kinetics/chain/kinetics[19]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[19]/MAPK*/diff /kinetics/chain/kinetics[19]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[19]/MAPK*/MAPK* SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK* /kinetics/chain/kinetics[19]/MAPK*/MAPK* ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1* /kinetics/chain/kinetics[19]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK* /kinetics/chain/kinetics[19]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK* /kinetics/chain/kinetics[19]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK* /kinetics/chain/kinetics[19]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[19]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[19]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[19]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[18]/MKP-1/diff /kinetics/chain/kinetics[19]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[19]/MKP-1/diff /kinetics/chain/kinetics[19]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr /kinetics/chain/kinetics[19]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MKP-1 /kinetics/chain/kinetics[19]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK* /kinetics/chain/kinetics[19]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MKP-1 /kinetics/chain/kinetics[19]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[19]/MKP-1 /kinetics/chain/kinetics[19]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MKP-1 /kinetics/chain/kinetics[19]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[19]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[19]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[19]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[19]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[18]/PPhosphatase2A/diff /kinetics/chain/kinetics[19]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/diff /kinetics/chain/kinetics[19]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1* /kinetics/chain/kinetics[19]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A /kinetics/chain/kinetics[19]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK* /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1** /kinetics/chain/kinetics[19]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A /kinetics/chain/kinetics[19]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A /kinetics/chain/kinetics[19]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A /kinetics/chain/kinetics[19]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[19]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM/diff /kinetics/chain/kinetics[19]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[19]/CaM/CaM/diff /kinetics/chain/kinetics[19]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM /kinetics/chain/kinetics[19]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM /kinetics/chain/kinetics[19]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ca /kinetics/chain/kinetics[19]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ca /kinetics/chain/kinetics[19]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM /kinetics/chain/kinetics[19]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[19]/CaM/CaM-TR2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ca /kinetics/chain/kinetics[19]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca3 /kinetics/chain/kinetics[19]/CaM/CaM-TR2-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[19]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca3 /kinetics/chain/kinetics[19]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 /kinetics/chain/kinetics[19]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[19]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[19]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca3 /kinetics/chain/kinetics[19]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca3 /kinetics/chain/kinetics[19]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[19]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[19]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[19]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[18]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[19]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[19]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[19]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[19]/CaM/CaM-TR2-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[19]/CaM/CaM-TR2-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[18]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca4 /kinetics/chain/kinetics[19]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 /kinetics/chain/kinetics[19]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/MAPK/craf-1 /kinetics/chain/kinetics[19]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[19]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ras/GTP-Ras /kinetics/chain/kinetics[19]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[19]/Ca_diff /kinetics/chain/kinetics[19]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[19]/Ca /kinetics/chain/kinetics[19]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[19]/Ca_input /kinetics/chain/kinetics[19]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[20]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[20]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[20]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[20]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[20]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[20]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca /kinetics/chain/kinetics[20]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca /kinetics/chain/kinetics[20]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ca /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[20]/DAG /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca /kinetics/chain/kinetics[20]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[20]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[20]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[20]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca-AA PRODUCT n addmsg /kinetics/chain/kinetics[20]/AA /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[20]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[20]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[20]/PKC/PKC-DAG-AA* REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[20]/PKC/PKC-DAG-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[20]/PKC/PKC-DAG-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[20]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[20]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[20]/PKC/PKC-Ca-AA* REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[20]/PKC/PKC-Ca-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[20]/PKC/PKC-Ca-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-basal-act /kinetics/chain/kinetics[20]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[20]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[20]/PKC/PKC-basal* REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-basal* /kinetics/chain/kinetics[20]/PKC/PKC-basal*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-basal* /kinetics/chain/kinetics[20]/PKC/PKC-basal*/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-basal* /kinetics/chain/kinetics[20]/PKC/PKC-basal-act PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic /kinetics/chain/kinetics[20]/PKC/PKC-basal-act SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[20]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[20]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[20]/PKC/PKC-AA* REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-AA* /kinetics/chain/kinetics[20]/PKC/PKC-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-AA* /kinetics/chain/kinetics[20]/PKC/PKC-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-AA* /kinetics/chain/kinetics[20]/PKC/PKC-act-by-AA PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic /kinetics/chain/kinetics[20]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/AA /kinetics/chain/kinetics[20]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/DAG /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG /kinetics/chain/kinetics[20]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[20]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[20]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[20]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG /kinetics/chain/kinetics[20]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG /kinetics/chain/kinetics[20]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[20]/AA /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[20]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[20]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[19]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[20]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[20]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[20]/PKC/PKC-DAG-AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[20]/PKC/PKC-DAG-AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-basal-act /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[20]/AA REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[20]/AA REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[20]/AA REAC A B addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[20]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[20]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[20]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[20]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[20]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[20]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[20]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[20]/PLA2/Degrade-AA /kinetics/chain/kinetics[20]/AA REAC A B addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[20]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[19]/AA/diff /kinetics/chain/kinetics[20]/AA REAC B A addmsg /kinetics/chain/kinetics[20]/AA/diff /kinetics/chain/kinetics[20]/AA REAC A B addmsg /kinetics/chain/kinetics[20]/AA /kinetics/chain/kinetics[20]/AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/AA /kinetics/chain/kinetics[20]/AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[20]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[20]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[20]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[20]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[20]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[20]/MAPK*/MAPK* /kinetics/chain/kinetics[20]/PLA2/PLA2-cytosolic REAC sA B addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[20]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[20]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[20]/PLA2/PLA2-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[20]/PLA2/PLA2-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ca /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca* REAC eA B addmsg /kinetics/chain/kinetics[20]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[20]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca*/kenz ENZYME n addmsg /kinetics/chain/kinetics[20]/PLA2/APC /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca*/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[20]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[20]/PLA2/PIP2-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[20]/temp-PIP2 /kinetics/chain/kinetics[20]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[20]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[20]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[20]/PLA2/PIP2-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[19]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[20]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[20]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[20]/PLA2/PIP2-PLA2* REAC A B addmsg /kinetics/chain/kinetics[20]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[20]/PLA2/PIP2-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[20]/PLA2/APC /kinetics/chain/kinetics[20]/PLA2/PIP2-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[20]/PLA2/PIP2-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[20]/PLA2/PIP2-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[20]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[20]/PLA2/PIP2-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[20]/temp-PIP2 /kinetics/chain/kinetics[20]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[20]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[20]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[20]/PLA2/PIP2-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[19]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[20]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[20]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[20]/PLA2/PIP2-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[20]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[20]/PLA2/PIP2-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[20]/PLA2/APC /kinetics/chain/kinetics[20]/PLA2/PIP2-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[20]/PLA2/PIP2-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[20]/PLA2/PIP2-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[20]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[20]/PLA2/DAG-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[20]/DAG /kinetics/chain/kinetics[20]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[20]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[20]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[20]/PLA2/DAG-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[19]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[20]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[20]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[20]/PLA2/DAG-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[20]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[20]/PLA2/DAG-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[20]/PLA2/APC /kinetics/chain/kinetics[20]/PLA2/DAG-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[20]/PLA2/DAG-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[20]/PLA2/DAG-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[20]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[20]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[20]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[20]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[20]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[20]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[20]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[20]/PLA2/Degrade-AA /kinetics/chain/kinetics[20]/PLA2/APC REAC B A addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[20]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[20]/AA /kinetics/chain/kinetics[20]/PLA2/Degrade-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PLA2/APC /kinetics/chain/kinetics[20]/PLA2/Degrade-AA PRODUCT n addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca REAC eA B addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca REAC A B addmsg /kinetics/chain/kinetics[20]/PLA2/APC /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca/kenz ENZYME n addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[20]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[20]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[20]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[20]/MAPK*/MAPK* /kinetics/chain/kinetics[20]/PLA2/PLA2* MM_PRD pA addmsg /kinetics/chain/kinetics[19]/PLA2/PLA2*/diff /kinetics/chain/kinetics[20]/PLA2/PLA2* REAC B A addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2*/diff /kinetics/chain/kinetics[20]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2* /kinetics/chain/kinetics[20]/PLA2/PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2* /kinetics/chain/kinetics[20]/PLA2/PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2* /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ca /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[20]/PLA2/dephosphorylate-PLA2* PRODUCT n addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2* /kinetics/chain/kinetics[20]/PLA2/dephosphorylate-PLA2* SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[20]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[20]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[20]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[20]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[20]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[20]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[20]/Ras-act-unphosph-raf /kinetics/chain/kinetics[20]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[20]/Ras-act-craf /kinetics/chain/kinetics[20]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[20]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[20]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[20]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[20]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[20]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[20]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[20]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[20]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[20]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[20]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[20]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK/diff /kinetics/chain/kinetics[20]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK/diff /kinetics/chain/kinetics[20]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK /kinetics/chain/kinetics[20]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK /kinetics/chain/kinetics[20]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[20]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[20]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[20]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[20]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[20]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[20]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[20]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[20]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[20]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK* /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK* /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[20]/Ras-act-unphosph-raf /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[20]/Ras-act-craf /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1* /kinetics/chain/kinetics[20]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[20]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ras/GTP-Ras /kinetics/chain/kinetics[20]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF /kinetics/chain/kinetics[20]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ras/GEF* /kinetics/chain/kinetics[20]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/dephosph-GEF /kinetics/chain/kinetics[20]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[20]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[20]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[20]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[20]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[20]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[19]/Ras/inact-GEF/diff /kinetics/chain/kinetics[20]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF/diff /kinetics/chain/kinetics[20]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF /kinetics/chain/kinetics[20]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[20]/Ras/GDP-Ras /kinetics/chain/kinetics[20]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF /kinetics/chain/kinetics[20]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF /kinetics/chain/kinetics[20]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ras/dephosph-GEF /kinetics/chain/kinetics[20]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[20]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[20]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[20]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[19]/Ras/GEF*/diff /kinetics/chain/kinetics[20]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[20]/Ras/GEF*/diff /kinetics/chain/kinetics[20]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/GEF* /kinetics/chain/kinetics[20]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[20]/Ras/GDP-Ras /kinetics/chain/kinetics[20]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/GEF* /kinetics/chain/kinetics[20]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/GEF* /kinetics/chain/kinetics[20]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ras-act-craf /kinetics/chain/kinetics[20]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[20]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[20]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[20]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[20]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[20]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[20]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[20]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[20]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[20]/Ras-act-unphosph-raf /kinetics/chain/kinetics[20]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[20]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[20]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[20]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[20]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[20]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[20]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[20]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[20]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[20]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[20]/Ras/GTP-Ras /kinetics/chain/kinetics[20]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/GDP-Ras /kinetics/chain/kinetics[20]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ras/GAP* /kinetics/chain/kinetics[20]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/GAP /kinetics/chain/kinetics[20]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ras/dephosph-GAP /kinetics/chain/kinetics[20]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[20]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[20]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[19]/Ras/GAP*/diff /kinetics/chain/kinetics[20]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[20]/Ras/GAP*/diff /kinetics/chain/kinetics[20]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/GAP* /kinetics/chain/kinetics[20]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/GAP* /kinetics/chain/kinetics[20]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ras/dephosph-GAP /kinetics/chain/kinetics[20]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[20]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[20]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[20]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[20]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[19]/Ras/GAP/diff /kinetics/chain/kinetics[20]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[20]/Ras/GAP/diff /kinetics/chain/kinetics[20]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/GTP-Ras /kinetics/chain/kinetics[20]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/GAP /kinetics/chain/kinetics[20]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[20]/Ras/GAP /kinetics/chain/kinetics[20]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/GAP /kinetics/chain/kinetics[20]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF /kinetics/chain/kinetics[20]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/CaM-GEF /kinetics/chain/kinetics[20]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 /kinetics/chain/kinetics[20]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[20]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[20]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[20]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[19]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[20]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[20]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[20]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[20]/Ras/GDP-Ras /kinetics/chain/kinetics[20]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ras/CaM-GEF /kinetics/chain/kinetics[20]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[20]/Ras/CaM-GEF /kinetics/chain/kinetics[20]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/CaM-GEF /kinetics/chain/kinetics[20]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[20]/Ca REAC A B addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[20]/Ca REAC A B addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[20]/Ca REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[20]/Ca REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[20]/Ca REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[20]/Ca REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[20]/Ca REAC A B addmsg /kinetics/chain/kinetics[20]/Ca_diff /kinetics/chain/kinetics[20]/Ca REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[20]/DAG REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG /kinetics/chain/kinetics[20]/DAG REAC A B addmsg /kinetics/chain/kinetics[20]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[20]/DAG REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[20]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[20]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[20]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[20]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[20]/PKC/PKC-basal* /kinetics/chain/kinetics[20]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[20]/PKC/PKC-AA* /kinetics/chain/kinetics[20]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[20]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[20]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[20]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[20]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[20]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[20]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[20]/PKC-active/phosph-AC2 /kinetics/chain/kinetics[20]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1 /kinetics/chain/kinetics[20]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC-active /kinetics/chain/kinetics[20]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[20]/Ras/GAP /kinetics/chain/kinetics[20]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC-active /kinetics/chain/kinetics[20]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF /kinetics/chain/kinetics[20]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PKC-active /kinetics/chain/kinetics[20]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[20]/PKC-active /kinetics/chain/kinetics[20]/PKC-active/phosph-AC2 ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[20]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MAPK*/MAPK* /kinetics/chain/kinetics[20]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[20]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[20]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[20]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[20]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[19]/MAPK*/diff /kinetics/chain/kinetics[20]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[20]/MAPK*/diff /kinetics/chain/kinetics[20]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[20]/MAPK*/MAPK* SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK* /kinetics/chain/kinetics[20]/MAPK*/MAPK* ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1* /kinetics/chain/kinetics[20]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK* /kinetics/chain/kinetics[20]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK* /kinetics/chain/kinetics[20]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK* /kinetics/chain/kinetics[20]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[20]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[20]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[20]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[19]/MKP-1/diff /kinetics/chain/kinetics[20]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[20]/MKP-1/diff /kinetics/chain/kinetics[20]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr /kinetics/chain/kinetics[20]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MKP-1 /kinetics/chain/kinetics[20]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK* /kinetics/chain/kinetics[20]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MKP-1 /kinetics/chain/kinetics[20]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[20]/MKP-1 /kinetics/chain/kinetics[20]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MKP-1 /kinetics/chain/kinetics[20]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[20]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[20]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[20]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[20]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[19]/PPhosphatase2A/diff /kinetics/chain/kinetics[20]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/diff /kinetics/chain/kinetics[20]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1* /kinetics/chain/kinetics[20]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A /kinetics/chain/kinetics[20]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK* /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1** /kinetics/chain/kinetics[20]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A /kinetics/chain/kinetics[20]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A /kinetics/chain/kinetics[20]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A /kinetics/chain/kinetics[20]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[20]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM/diff /kinetics/chain/kinetics[20]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[20]/CaM/CaM/diff /kinetics/chain/kinetics[20]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM /kinetics/chain/kinetics[20]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM /kinetics/chain/kinetics[20]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ca /kinetics/chain/kinetics[20]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ca /kinetics/chain/kinetics[20]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM /kinetics/chain/kinetics[20]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[20]/CaM/CaM-TR2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ca /kinetics/chain/kinetics[20]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca3 /kinetics/chain/kinetics[20]/CaM/CaM-TR2-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[20]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca3 /kinetics/chain/kinetics[20]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 /kinetics/chain/kinetics[20]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[20]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[20]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca3 /kinetics/chain/kinetics[20]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca3 /kinetics/chain/kinetics[20]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[20]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[20]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[20]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[19]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[20]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[20]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[20]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[20]/CaM/CaM-TR2-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[20]/CaM/CaM-TR2-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[19]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca4 /kinetics/chain/kinetics[20]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca4 /kinetics/chain/kinetics[20]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/MAPK/craf-1 /kinetics/chain/kinetics[20]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[20]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ras/GTP-Ras /kinetics/chain/kinetics[20]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[20]/Ca_diff /kinetics/chain/kinetics[20]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[20]/Ca /kinetics/chain/kinetics[20]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[20]/Ca_input /kinetics/chain/kinetics[20]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[21]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[21]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[21]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[21]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[21]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[21]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca /kinetics/chain/kinetics[21]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca /kinetics/chain/kinetics[21]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ca /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca /kinetics/chain/kinetics[21]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[21]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[21]/DAG /kinetics/chain/kinetics[21]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca /kinetics/chain/kinetics[21]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[21]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[21]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[21]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca-AA PRODUCT n addmsg /kinetics/chain/kinetics[21]/AA /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[21]/PKC/PKC-act-by-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[21]/PKC/PKC-act-by-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[21]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[21]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[21]/PKC/PKC-DAG-AA* REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[21]/PKC/PKC-DAG-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[21]/PKC/PKC-DAG-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[21]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[21]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[21]/PKC/PKC-Ca-AA* REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[21]/PKC/PKC-Ca-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[21]/PKC/PKC-Ca-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-basal-act /kinetics/chain/kinetics[21]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[21]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[21]/PKC/PKC-basal* REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-basal* /kinetics/chain/kinetics[21]/PKC/PKC-basal*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-basal* /kinetics/chain/kinetics[21]/PKC/PKC-basal*/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-basal* /kinetics/chain/kinetics[21]/PKC/PKC-basal-act PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic /kinetics/chain/kinetics[21]/PKC/PKC-basal-act SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[21]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[21]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[21]/PKC/PKC-AA* REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-AA* /kinetics/chain/kinetics[21]/PKC/PKC-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-AA* /kinetics/chain/kinetics[21]/PKC/PKC-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-AA* /kinetics/chain/kinetics[21]/PKC/PKC-act-by-AA PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic /kinetics/chain/kinetics[21]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/AA /kinetics/chain/kinetics[21]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/DAG /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG /kinetics/chain/kinetics[21]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[21]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[21]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[21]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG /kinetics/chain/kinetics[21]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG /kinetics/chain/kinetics[21]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[21]/AA /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[21]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[21]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[20]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[21]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[21]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[21]/PKC/PKC-DAG-AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[21]/PKC/PKC-DAG-AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-basal-act /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[21]/AA REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[21]/AA REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[21]/AA REAC A B addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[21]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[21]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[21]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[21]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[21]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[21]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[21]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[21]/PLA2/Degrade-AA /kinetics/chain/kinetics[21]/AA REAC A B addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[21]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[20]/AA/diff /kinetics/chain/kinetics[21]/AA REAC B A addmsg /kinetics/chain/kinetics[21]/AA/diff /kinetics/chain/kinetics[21]/AA REAC A B addmsg /kinetics/chain/kinetics[21]/AA /kinetics/chain/kinetics[21]/AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/AA /kinetics/chain/kinetics[21]/AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[21]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[21]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[21]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[21]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[21]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[21]/MAPK*/MAPK* /kinetics/chain/kinetics[21]/PLA2/PLA2-cytosolic REAC sA B addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[21]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[21]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[21]/PLA2/PLA2-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[21]/PLA2/PLA2-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ca /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca* REAC eA B addmsg /kinetics/chain/kinetics[21]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[21]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca*/kenz ENZYME n addmsg /kinetics/chain/kinetics[21]/PLA2/APC /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca*/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[21]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[21]/PLA2/PIP2-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[21]/temp-PIP2 /kinetics/chain/kinetics[21]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[21]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[21]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[21]/PLA2/PIP2-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[20]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[21]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[21]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[21]/PLA2/PIP2-PLA2* REAC A B addmsg /kinetics/chain/kinetics[21]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[21]/PLA2/PIP2-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[21]/PLA2/APC /kinetics/chain/kinetics[21]/PLA2/PIP2-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[21]/PLA2/PIP2-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[21]/PLA2/PIP2-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[21]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[21]/PLA2/PIP2-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[21]/temp-PIP2 /kinetics/chain/kinetics[21]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[21]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[21]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[21]/PLA2/PIP2-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[20]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[21]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[21]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[21]/PLA2/PIP2-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[21]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[21]/PLA2/PIP2-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[21]/PLA2/APC /kinetics/chain/kinetics[21]/PLA2/PIP2-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[21]/PLA2/PIP2-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[21]/PLA2/PIP2-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[21]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[21]/PLA2/DAG-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[21]/DAG /kinetics/chain/kinetics[21]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[21]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[21]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[21]/PLA2/DAG-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[20]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[21]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[21]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[21]/PLA2/DAG-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[21]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[21]/PLA2/DAG-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[21]/PLA2/APC /kinetics/chain/kinetics[21]/PLA2/DAG-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[21]/PLA2/DAG-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[21]/PLA2/DAG-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[21]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[21]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[21]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[21]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[21]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[21]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[21]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[21]/PLA2/Degrade-AA /kinetics/chain/kinetics[21]/PLA2/APC REAC B A addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[21]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[21]/AA /kinetics/chain/kinetics[21]/PLA2/Degrade-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PLA2/APC /kinetics/chain/kinetics[21]/PLA2/Degrade-AA PRODUCT n addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca REAC eA B addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca REAC A B addmsg /kinetics/chain/kinetics[21]/PLA2/APC /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca/kenz ENZYME n addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[21]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[21]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[21]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[21]/MAPK*/MAPK* /kinetics/chain/kinetics[21]/PLA2/PLA2* MM_PRD pA addmsg /kinetics/chain/kinetics[20]/PLA2/PLA2*/diff /kinetics/chain/kinetics[21]/PLA2/PLA2* REAC B A addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2*/diff /kinetics/chain/kinetics[21]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2* /kinetics/chain/kinetics[21]/PLA2/PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2* /kinetics/chain/kinetics[21]/PLA2/PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2* /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ca /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[21]/PLA2/dephosphorylate-PLA2* PRODUCT n addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2* /kinetics/chain/kinetics[21]/PLA2/dephosphorylate-PLA2* SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[21]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[21]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[21]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[21]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[21]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[21]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[21]/Ras-act-unphosph-raf /kinetics/chain/kinetics[21]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[21]/Ras-act-craf /kinetics/chain/kinetics[21]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[21]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[21]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[21]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[21]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[21]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[21]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[21]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[21]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[21]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[21]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[21]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK/diff /kinetics/chain/kinetics[21]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK/diff /kinetics/chain/kinetics[21]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK /kinetics/chain/kinetics[21]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK /kinetics/chain/kinetics[21]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[21]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[21]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[21]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[21]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[21]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[21]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[21]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[21]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[21]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK* /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK* /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[21]/Ras-act-unphosph-raf /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[21]/Ras-act-craf /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1* /kinetics/chain/kinetics[21]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[21]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ras/GTP-Ras /kinetics/chain/kinetics[21]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF /kinetics/chain/kinetics[21]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ras/GEF* /kinetics/chain/kinetics[21]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/dephosph-GEF /kinetics/chain/kinetics[21]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[21]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[21]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[21]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[21]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[21]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[20]/Ras/inact-GEF/diff /kinetics/chain/kinetics[21]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF/diff /kinetics/chain/kinetics[21]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF /kinetics/chain/kinetics[21]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[21]/Ras/GDP-Ras /kinetics/chain/kinetics[21]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF /kinetics/chain/kinetics[21]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF /kinetics/chain/kinetics[21]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ras/dephosph-GEF /kinetics/chain/kinetics[21]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[21]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[21]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[21]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[20]/Ras/GEF*/diff /kinetics/chain/kinetics[21]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[21]/Ras/GEF*/diff /kinetics/chain/kinetics[21]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/GEF* /kinetics/chain/kinetics[21]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[21]/Ras/GDP-Ras /kinetics/chain/kinetics[21]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/GEF* /kinetics/chain/kinetics[21]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/GEF* /kinetics/chain/kinetics[21]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ras-act-craf /kinetics/chain/kinetics[21]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[21]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[21]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[21]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[21]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[21]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[21]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[21]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[21]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[21]/Ras-act-unphosph-raf /kinetics/chain/kinetics[21]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[21]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[21]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[21]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[21]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[21]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[21]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[21]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[21]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[21]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[21]/Ras/GTP-Ras /kinetics/chain/kinetics[21]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/GDP-Ras /kinetics/chain/kinetics[21]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ras/GAP* /kinetics/chain/kinetics[21]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/GAP /kinetics/chain/kinetics[21]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ras/dephosph-GAP /kinetics/chain/kinetics[21]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[21]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[21]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[20]/Ras/GAP*/diff /kinetics/chain/kinetics[21]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[21]/Ras/GAP*/diff /kinetics/chain/kinetics[21]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/GAP* /kinetics/chain/kinetics[21]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/GAP* /kinetics/chain/kinetics[21]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ras/dephosph-GAP /kinetics/chain/kinetics[21]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[21]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[21]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[21]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[21]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[20]/Ras/GAP/diff /kinetics/chain/kinetics[21]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[21]/Ras/GAP/diff /kinetics/chain/kinetics[21]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/GTP-Ras /kinetics/chain/kinetics[21]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/GAP /kinetics/chain/kinetics[21]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[21]/Ras/GAP /kinetics/chain/kinetics[21]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/GAP /kinetics/chain/kinetics[21]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF /kinetics/chain/kinetics[21]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/CaM-GEF /kinetics/chain/kinetics[21]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca4 /kinetics/chain/kinetics[21]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[21]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[21]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[21]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[20]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[21]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[21]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[21]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[21]/Ras/GDP-Ras /kinetics/chain/kinetics[21]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ras/CaM-GEF /kinetics/chain/kinetics[21]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[21]/Ras/CaM-GEF /kinetics/chain/kinetics[21]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/CaM-GEF /kinetics/chain/kinetics[21]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[21]/Ca REAC A B addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[21]/Ca REAC A B addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[21]/Ca REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[21]/Ca REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[21]/Ca REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[21]/Ca REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[21]/Ca REAC A B addmsg /kinetics/chain/kinetics[21]/Ca_diff /kinetics/chain/kinetics[21]/Ca REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[21]/DAG REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG /kinetics/chain/kinetics[21]/DAG REAC A B addmsg /kinetics/chain/kinetics[21]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[21]/DAG REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[21]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[21]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[21]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[21]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[21]/PKC/PKC-basal* /kinetics/chain/kinetics[21]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[21]/PKC/PKC-AA* /kinetics/chain/kinetics[21]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[21]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[21]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[21]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[21]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[21]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[21]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[21]/PKC-active/phosph-AC2 /kinetics/chain/kinetics[21]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1 /kinetics/chain/kinetics[21]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC-active /kinetics/chain/kinetics[21]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[21]/Ras/GAP /kinetics/chain/kinetics[21]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC-active /kinetics/chain/kinetics[21]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF /kinetics/chain/kinetics[21]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PKC-active /kinetics/chain/kinetics[21]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[21]/PKC-active /kinetics/chain/kinetics[21]/PKC-active/phosph-AC2 ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[21]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MAPK*/MAPK* /kinetics/chain/kinetics[21]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[21]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[21]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[21]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[21]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[20]/MAPK*/diff /kinetics/chain/kinetics[21]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[21]/MAPK*/diff /kinetics/chain/kinetics[21]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[21]/MAPK*/MAPK* SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK* /kinetics/chain/kinetics[21]/MAPK*/MAPK* ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1* /kinetics/chain/kinetics[21]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK* /kinetics/chain/kinetics[21]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK* /kinetics/chain/kinetics[21]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK* /kinetics/chain/kinetics[21]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[21]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[21]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[21]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[20]/MKP-1/diff /kinetics/chain/kinetics[21]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[21]/MKP-1/diff /kinetics/chain/kinetics[21]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr /kinetics/chain/kinetics[21]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MKP-1 /kinetics/chain/kinetics[21]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK* /kinetics/chain/kinetics[21]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MKP-1 /kinetics/chain/kinetics[21]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[21]/MKP-1 /kinetics/chain/kinetics[21]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MKP-1 /kinetics/chain/kinetics[21]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[21]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[21]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[21]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[21]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[20]/PPhosphatase2A/diff /kinetics/chain/kinetics[21]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/diff /kinetics/chain/kinetics[21]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1* /kinetics/chain/kinetics[21]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A /kinetics/chain/kinetics[21]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK* /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1** /kinetics/chain/kinetics[21]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A /kinetics/chain/kinetics[21]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A /kinetics/chain/kinetics[21]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A /kinetics/chain/kinetics[21]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[21]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM/diff /kinetics/chain/kinetics[21]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[21]/CaM/CaM/diff /kinetics/chain/kinetics[21]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM /kinetics/chain/kinetics[21]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM /kinetics/chain/kinetics[21]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ca /kinetics/chain/kinetics[21]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ca /kinetics/chain/kinetics[21]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM /kinetics/chain/kinetics[21]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[21]/CaM/CaM-TR2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ca /kinetics/chain/kinetics[21]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca3 /kinetics/chain/kinetics[21]/CaM/CaM-TR2-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[21]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca3 /kinetics/chain/kinetics[21]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca4 /kinetics/chain/kinetics[21]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[21]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[21]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca3 /kinetics/chain/kinetics[21]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca3 /kinetics/chain/kinetics[21]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[21]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[21]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[21]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[20]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[21]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[21]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[21]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[21]/CaM/CaM-TR2-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[21]/CaM/CaM-TR2-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[21]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[21]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[20]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[21]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[21]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca4 /kinetics/chain/kinetics[21]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca4 /kinetics/chain/kinetics[21]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/MAPK/craf-1 /kinetics/chain/kinetics[21]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[21]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ras/GTP-Ras /kinetics/chain/kinetics[21]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[21]/Ca_diff /kinetics/chain/kinetics[21]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[21]/Ca /kinetics/chain/kinetics[21]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[21]/Ca_input /kinetics/chain/kinetics[21]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[22]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[22]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[22]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[22]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[22]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[22]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca /kinetics/chain/kinetics[22]/PKC/PKC-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca /kinetics/chain/kinetics[22]/PKC/PKC-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ca /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca /kinetics/chain/kinetics[22]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[22]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[22]/DAG /kinetics/chain/kinetics[22]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca /kinetics/chain/kinetics[22]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[22]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[22]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[22]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca-AA PRODUCT n addmsg /kinetics/chain/kinetics[22]/AA /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[22]/PKC/PKC-act-by-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[22]/PKC/PKC-act-by-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[22]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[22]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[22]/PKC/PKC-DAG-AA* REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[22]/PKC/PKC-DAG-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[22]/PKC/PKC-DAG-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[22]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[22]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[22]/PKC/PKC-Ca-AA* REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[22]/PKC/PKC-Ca-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[22]/PKC/PKC-Ca-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb* REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb* REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb*/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-basal-act /kinetics/chain/kinetics[22]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[22]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[22]/PKC/PKC-basal* REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-basal* /kinetics/chain/kinetics[22]/PKC/PKC-basal*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-basal* /kinetics/chain/kinetics[22]/PKC/PKC-basal*/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-basal* /kinetics/chain/kinetics[22]/PKC/PKC-basal-act PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic /kinetics/chain/kinetics[22]/PKC/PKC-basal-act SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[22]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[22]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[22]/PKC/PKC-AA* REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-AA* /kinetics/chain/kinetics[22]/PKC/PKC-AA*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-AA* /kinetics/chain/kinetics[22]/PKC/PKC-AA*/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-AA* /kinetics/chain/kinetics[22]/PKC/PKC-act-by-AA PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic /kinetics/chain/kinetics[22]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/AA /kinetics/chain/kinetics[22]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/DAG /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG /kinetics/chain/kinetics[22]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[22]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[22]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[22]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG /kinetics/chain/kinetics[22]/PKC/PKC-DAG/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG /kinetics/chain/kinetics[22]/PKC/PKC-DAG/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[22]/AA /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[22]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[22]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[21]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[22]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[22]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[22]/PKC/PKC-DAG-AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[22]/PKC/PKC-DAG-AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-basal-act /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[22]/AA REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[22]/AA REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[22]/AA REAC A B addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[22]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[22]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[22]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[22]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[22]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[22]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[22]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[22]/PLA2/Degrade-AA /kinetics/chain/kinetics[22]/AA REAC A B addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[22]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[21]/AA/diff /kinetics/chain/kinetics[22]/AA REAC B A addmsg /kinetics/chain/kinetics[22]/AA/diff /kinetics/chain/kinetics[22]/AA REAC A B addmsg /kinetics/chain/kinetics[22]/AA /kinetics/chain/kinetics[22]/AA/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/AA /kinetics/chain/kinetics[22]/AA/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[22]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[22]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[22]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[22]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[22]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[22]/MAPK*/MAPK* /kinetics/chain/kinetics[22]/PLA2/PLA2-cytosolic REAC sA B addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[22]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[22]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[22]/PLA2/PLA2-cytosolic/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[22]/PLA2/PLA2-cytosolic/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ca /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca* REAC eA B addmsg /kinetics/chain/kinetics[22]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[22]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca*/kenz ENZYME n addmsg /kinetics/chain/kinetics[22]/PLA2/APC /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca*/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[22]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[22]/PLA2/PIP2-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[22]/temp-PIP2 /kinetics/chain/kinetics[22]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[22]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[22]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[22]/PLA2/PIP2-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[21]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[22]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[22]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[22]/PLA2/PIP2-PLA2* REAC A B addmsg /kinetics/chain/kinetics[22]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[22]/PLA2/PIP2-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[22]/PLA2/APC /kinetics/chain/kinetics[22]/PLA2/PIP2-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[22]/PLA2/PIP2-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[22]/PLA2/PIP2-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[22]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[22]/PLA2/PIP2-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[22]/temp-PIP2 /kinetics/chain/kinetics[22]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[22]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[22]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[22]/PLA2/PIP2-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[21]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[22]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[22]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[22]/PLA2/PIP2-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[22]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[22]/PLA2/PIP2-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[22]/PLA2/APC /kinetics/chain/kinetics[22]/PLA2/PIP2-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[22]/PLA2/PIP2-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[22]/PLA2/PIP2-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[22]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[22]/PLA2/DAG-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[22]/DAG /kinetics/chain/kinetics[22]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[22]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[22]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[22]/PLA2/DAG-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[21]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[22]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[22]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[22]/PLA2/DAG-Ca-PLA2* REAC A B addmsg /kinetics/chain/kinetics[22]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[22]/PLA2/DAG-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[22]/PLA2/APC /kinetics/chain/kinetics[22]/PLA2/DAG-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[22]/PLA2/DAG-Ca-PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[22]/PLA2/DAG-Ca-PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[22]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[22]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[22]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[22]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[22]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[22]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[22]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[22]/PLA2/Degrade-AA /kinetics/chain/kinetics[22]/PLA2/APC REAC B A addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[22]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[22]/AA /kinetics/chain/kinetics[22]/PLA2/Degrade-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PLA2/APC /kinetics/chain/kinetics[22]/PLA2/Degrade-AA PRODUCT n addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca REAC eA B addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca REAC A B addmsg /kinetics/chain/kinetics[22]/PLA2/APC /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca/kenz ENZYME n addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[22]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[22]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[22]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[22]/MAPK*/MAPK* /kinetics/chain/kinetics[22]/PLA2/PLA2* MM_PRD pA addmsg /kinetics/chain/kinetics[21]/PLA2/PLA2*/diff /kinetics/chain/kinetics[22]/PLA2/PLA2* REAC B A addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2*/diff /kinetics/chain/kinetics[22]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2* /kinetics/chain/kinetics[22]/PLA2/PLA2*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PLA2/PLA2* /kinetics/chain/kinetics[22]/PLA2/PLA2*/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2* /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ca /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[22]/PLA2/dephosphorylate-PLA2* PRODUCT n addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2* /kinetics/chain/kinetics[22]/PLA2/dephosphorylate-PLA2* SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[22]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[22]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[22]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[22]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[22]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[22]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[22]/Ras-act-unphosph-raf /kinetics/chain/kinetics[22]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[22]/Ras-act-craf /kinetics/chain/kinetics[22]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[22]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[22]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[22]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[22]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[22]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[22]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[22]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[22]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[22]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[22]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[22]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK/diff /kinetics/chain/kinetics[22]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK/diff /kinetics/chain/kinetics[22]/MAPK/MAPK REAC A B addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK /kinetics/chain/kinetics[22]/MAPK/MAPK/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPK /kinetics/chain/kinetics[22]/MAPK/MAPK/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[22]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[22]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[22]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[22]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr REAC A B addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[22]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[22]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[22]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[22]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[22]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK* /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK* /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[22]/Ras-act-unphosph-raf /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[22]/Ras-act-craf /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1* /kinetics/chain/kinetics[22]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[22]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ras/GTP-Ras /kinetics/chain/kinetics[22]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF /kinetics/chain/kinetics[22]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ras/GEF* /kinetics/chain/kinetics[22]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/dephosph-GEF /kinetics/chain/kinetics[22]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[22]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[22]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[22]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[22]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[22]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[21]/Ras/inact-GEF/diff /kinetics/chain/kinetics[22]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF/diff /kinetics/chain/kinetics[22]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF /kinetics/chain/kinetics[22]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[22]/Ras/GDP-Ras /kinetics/chain/kinetics[22]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF /kinetics/chain/kinetics[22]/Ras/inact-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/inact-GEF /kinetics/chain/kinetics[22]/Ras/inact-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ras/dephosph-GEF /kinetics/chain/kinetics[22]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[22]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[22]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[22]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[21]/Ras/GEF*/diff /kinetics/chain/kinetics[22]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[22]/Ras/GEF*/diff /kinetics/chain/kinetics[22]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/GEF* /kinetics/chain/kinetics[22]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[22]/Ras/GDP-Ras /kinetics/chain/kinetics[22]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/GEF* /kinetics/chain/kinetics[22]/Ras/GEF*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/GEF* /kinetics/chain/kinetics[22]/Ras/GEF*/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ras-act-craf /kinetics/chain/kinetics[22]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[22]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[22]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[22]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[22]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[22]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[22]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[22]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[22]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[22]/Ras-act-unphosph-raf /kinetics/chain/kinetics[22]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[22]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[22]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[22]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[22]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[22]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[22]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[22]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[22]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[22]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[22]/Ras/GTP-Ras /kinetics/chain/kinetics[22]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/GDP-Ras /kinetics/chain/kinetics[22]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ras/GAP* /kinetics/chain/kinetics[22]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/GAP /kinetics/chain/kinetics[22]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ras/dephosph-GAP /kinetics/chain/kinetics[22]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[22]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[22]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[21]/Ras/GAP*/diff /kinetics/chain/kinetics[22]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[22]/Ras/GAP*/diff /kinetics/chain/kinetics[22]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/GAP* /kinetics/chain/kinetics[22]/Ras/GAP*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/GAP* /kinetics/chain/kinetics[22]/Ras/GAP*/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ras/dephosph-GAP /kinetics/chain/kinetics[22]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[22]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[22]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[22]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[22]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[21]/Ras/GAP/diff /kinetics/chain/kinetics[22]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[22]/Ras/GAP/diff /kinetics/chain/kinetics[22]/Ras/GAP REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/GTP-Ras /kinetics/chain/kinetics[22]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/GAP /kinetics/chain/kinetics[22]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[22]/Ras/GAP /kinetics/chain/kinetics[22]/Ras/GAP/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/GAP /kinetics/chain/kinetics[22]/Ras/GAP/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF /kinetics/chain/kinetics[22]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/CaM-GEF /kinetics/chain/kinetics[22]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca4 /kinetics/chain/kinetics[22]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[22]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[22]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[22]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[21]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[22]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[22]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[22]/Ras/CaM-GEF REAC A B addmsg /kinetics/chain/kinetics[22]/Ras/GDP-Ras /kinetics/chain/kinetics[22]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ras/CaM-GEF /kinetics/chain/kinetics[22]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[22]/Ras/CaM-GEF /kinetics/chain/kinetics[22]/Ras/CaM-GEF/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/CaM-GEF /kinetics/chain/kinetics[22]/Ras/CaM-GEF/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[22]/Ca REAC A B addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[22]/Ca REAC A B addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[22]/Ca REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[22]/Ca REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[22]/Ca REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[22]/Ca REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[22]/Ca REAC A B addmsg /kinetics/chain/kinetics[22]/Ca_diff /kinetics/chain/kinetics[22]/Ca REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[22]/DAG REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG /kinetics/chain/kinetics[22]/DAG REAC A B addmsg /kinetics/chain/kinetics[22]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[22]/DAG REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[22]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[22]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[22]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[22]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[22]/PKC/PKC-basal* /kinetics/chain/kinetics[22]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[22]/PKC/PKC-AA* /kinetics/chain/kinetics[22]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[22]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[22]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[22]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[22]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[22]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[22]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[22]/PKC-active/phosph-AC2 /kinetics/chain/kinetics[22]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1 /kinetics/chain/kinetics[22]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC-active /kinetics/chain/kinetics[22]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[22]/Ras/GAP /kinetics/chain/kinetics[22]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC-active /kinetics/chain/kinetics[22]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF /kinetics/chain/kinetics[22]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PKC-active /kinetics/chain/kinetics[22]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[22]/PKC-active /kinetics/chain/kinetics[22]/PKC-active/phosph-AC2 ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[22]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MAPK*/MAPK* /kinetics/chain/kinetics[22]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[22]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[22]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[22]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[22]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[21]/MAPK*/diff /kinetics/chain/kinetics[22]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[22]/MAPK*/diff /kinetics/chain/kinetics[22]/MAPK* REAC A B addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[22]/MAPK*/MAPK* SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK* /kinetics/chain/kinetics[22]/MAPK*/MAPK* ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1* /kinetics/chain/kinetics[22]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK* /kinetics/chain/kinetics[22]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK* /kinetics/chain/kinetics[22]/MAPK*/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK* /kinetics/chain/kinetics[22]/MAPK*/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[22]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[22]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[22]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[21]/MKP-1/diff /kinetics/chain/kinetics[22]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[22]/MKP-1/diff /kinetics/chain/kinetics[22]/MKP-1 REAC A B addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr /kinetics/chain/kinetics[22]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MKP-1 /kinetics/chain/kinetics[22]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK* /kinetics/chain/kinetics[22]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MKP-1 /kinetics/chain/kinetics[22]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[22]/MKP-1 /kinetics/chain/kinetics[22]/MKP-1/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MKP-1 /kinetics/chain/kinetics[22]/MKP-1/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[22]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[22]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[22]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[22]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[21]/PPhosphatase2A/diff /kinetics/chain/kinetics[22]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/diff /kinetics/chain/kinetics[22]/PPhosphatase2A REAC A B addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1* /kinetics/chain/kinetics[22]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A /kinetics/chain/kinetics[22]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK* /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1** /kinetics/chain/kinetics[22]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A /kinetics/chain/kinetics[22]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A /kinetics/chain/kinetics[22]/PPhosphatase2A/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A /kinetics/chain/kinetics[22]/PPhosphatase2A/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[22]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM/diff /kinetics/chain/kinetics[22]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[22]/CaM/CaM/diff /kinetics/chain/kinetics[22]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM /kinetics/chain/kinetics[22]/CaM/CaM/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM /kinetics/chain/kinetics[22]/CaM/CaM/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ca /kinetics/chain/kinetics[22]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ca /kinetics/chain/kinetics[22]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM /kinetics/chain/kinetics[22]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[22]/CaM/CaM-TR2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ca /kinetics/chain/kinetics[22]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca3 /kinetics/chain/kinetics[22]/CaM/CaM-TR2-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[22]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca3 /kinetics/chain/kinetics[22]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca4 /kinetics/chain/kinetics[22]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[22]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[22]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca3 /kinetics/chain/kinetics[22]/CaM/CaM-Ca3/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca3 /kinetics/chain/kinetics[22]/CaM/CaM-Ca3/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[22]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[22]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[22]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[21]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[22]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[22]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[22]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[22]/CaM/CaM-TR2-Ca2/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[22]/CaM/CaM-TR2-Ca2/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[22]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[22]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[21]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[22]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[22]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca4 /kinetics/chain/kinetics[22]/CaM/CaM-Ca4/diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca4 /kinetics/chain/kinetics[22]/CaM/CaM-Ca4/diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/MAPK/craf-1 /kinetics/chain/kinetics[22]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[22]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ras/GTP-Ras /kinetics/chain/kinetics[22]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[22]/Ca_diff /kinetics/chain/kinetics[22]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[22]/Ca /kinetics/chain/kinetics[22]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[22]/Ca_input /kinetics/chain/kinetics[22]/Ca_diff SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[23]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[23]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[23]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[23]/PKC/PKC-Ca REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca/diff /kinetics/chain/kinetics[23]/PKC/PKC-Ca REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ca /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca /kinetics/chain/kinetics[23]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[23]/PKC/PKC-act-by-DAG PRODUCT n addmsg /kinetics/chain/kinetics[23]/DAG /kinetics/chain/kinetics[23]/PKC/PKC-act-by-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca /kinetics/chain/kinetics[23]/PKC/PKC-Ca-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[23]/PKC/PKC-Ca-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[23]/PKC/PKC-DAG-to-memb PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-DAG /kinetics/chain/kinetics[23]/PKC/PKC-DAG-to-memb SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca-AA PRODUCT n addmsg /kinetics/chain/kinetics[23]/AA /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[23]/PKC/PKC-act-by-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[23]/PKC/PKC-act-by-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[23]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-AA*/diff /kinetics/chain/kinetics[23]/PKC/PKC-DAG-AA* REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[23]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-AA*/diff /kinetics/chain/kinetics[23]/PKC/PKC-Ca-AA* REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-to-memb /kinetics/chain/kinetics[23]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-memb*/diff /kinetics/chain/kinetics[23]/PKC/PKC-Ca-memb* REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[23]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-memb*/diff /kinetics/chain/kinetics[23]/PKC/PKC-DAG-memb* REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-basal-act /kinetics/chain/kinetics[23]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-basal*/diff /kinetics/chain/kinetics[23]/PKC/PKC-basal* REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-basal* /kinetics/chain/kinetics[23]/PKC/PKC-basal-act PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic /kinetics/chain/kinetics[23]/PKC/PKC-basal-act SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[23]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-AA*/diff /kinetics/chain/kinetics[23]/PKC/PKC-AA* REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-AA* /kinetics/chain/kinetics[23]/PKC/PKC-act-by-AA PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic /kinetics/chain/kinetics[23]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/AA /kinetics/chain/kinetics[23]/PKC/PKC-act-by-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[23]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG-to-memb /kinetics/chain/kinetics[23]/PKC/PKC-Ca-DAG REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-Ca-DAG/diff /kinetics/chain/kinetics[23]/PKC/PKC-Ca-DAG REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG PRODUCT n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/DAG /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG /kinetics/chain/kinetics[23]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[23]/PKC/PKC-DAG REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG/diff /kinetics/chain/kinetics[23]/PKC/PKC-DAG REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG-AA /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG-AA PRODUCT n addmsg /kinetics/chain/kinetics[23]/AA /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-act-by-DAG-AA /kinetics/chain/kinetics[23]/PKC/PKC-DAG-AA REAC A B addmsg /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[23]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[22]/PKC/PKC-DAG-AA/diff /kinetics/chain/kinetics[23]/PKC/PKC-DAG-AA REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[23]/PKC/PKC-basal-act /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[23]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic REAC A B addmsg /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic/diff /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca-AA /kinetics/chain/kinetics[23]/AA REAC A B addmsg /kinetics/chain/kinetics[23]/PKC/PKC-act-by-AA /kinetics/chain/kinetics[23]/AA REAC A B addmsg /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG-AA /kinetics/chain/kinetics[23]/AA REAC A B addmsg /kinetics/chain/kinetics[23]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[23]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[23]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[23]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[23]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[23]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[23]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[23]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[23]/PLA2/Degrade-AA /kinetics/chain/kinetics[23]/AA REAC A B addmsg /kinetics/chain/kinetics[23]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[23]/AA MM_PRD pA addmsg /kinetics/chain/kinetics[22]/AA/diff /kinetics/chain/kinetics[23]/AA REAC B A addmsg /kinetics/chain/kinetics[23]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[23]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[23]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[23]/PLA2/PLA2-cytosolic REAC A B addmsg /kinetics/chain/kinetics[23]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[23]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[23]/MAPK*/MAPK* /kinetics/chain/kinetics[23]/PLA2/PLA2-cytosolic REAC sA B addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2-cytosolic/diff /kinetics/chain/kinetics[23]/PLA2/PLA2-cytosolic REAC B A addmsg /kinetics/chain/kinetics[23]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[23]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[23]/PLA2/PLA2-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ca /kinetics/chain/kinetics[23]/PLA2/PLA2-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[23]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[23]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[23]/PLA2/PLA2-Ca* REAC eA B addmsg /kinetics/chain/kinetics[23]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[23]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[23]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[23]/PLA2/PLA2-Ca* REAC A B addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca*/diff /kinetics/chain/kinetics[23]/PLA2/PLA2-Ca* REAC B A addmsg /kinetics/chain/kinetics[23]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[23]/PLA2/PLA2-Ca*/kenz ENZYME n addmsg /kinetics/chain/kinetics[23]/PLA2/APC /kinetics/chain/kinetics[23]/PLA2/PLA2-Ca*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[23]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[23]/PLA2/PIP2-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[23]/temp-PIP2 /kinetics/chain/kinetics[23]/PLA2/PIP2-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[23]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[23]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[23]/PLA2/PIP2-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[22]/PLA2/PIP2-PLA2*/diff /kinetics/chain/kinetics[23]/PLA2/PIP2-PLA2* REAC B A addmsg /kinetics/chain/kinetics[23]/PLA2/PIP2-PLA2* /kinetics/chain/kinetics[23]/PLA2/PIP2-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[23]/PLA2/APC /kinetics/chain/kinetics[23]/PLA2/PIP2-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[23]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[23]/PLA2/PIP2-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[23]/temp-PIP2 /kinetics/chain/kinetics[23]/PLA2/PIP2-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[23]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[23]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[23]/PLA2/PIP2-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[22]/PLA2/PIP2-Ca-PLA2*/diff /kinetics/chain/kinetics[23]/PLA2/PIP2-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[23]/PLA2/PIP2-Ca-PLA2* /kinetics/chain/kinetics[23]/PLA2/PIP2-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[23]/PLA2/APC /kinetics/chain/kinetics[23]/PLA2/PIP2-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PLA2/PLA2-Ca* /kinetics/chain/kinetics[23]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[23]/PLA2/DAG-Ca-PLA2-act PRODUCT n addmsg /kinetics/chain/kinetics[23]/DAG /kinetics/chain/kinetics[23]/PLA2/DAG-Ca-PLA2-act SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[23]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[23]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[23]/PLA2/DAG-Ca-PLA2* REAC eA B addmsg /kinetics/chain/kinetics[22]/PLA2/DAG-Ca-PLA2*/diff /kinetics/chain/kinetics[23]/PLA2/DAG-Ca-PLA2* REAC B A addmsg /kinetics/chain/kinetics[23]/PLA2/DAG-Ca-PLA2* /kinetics/chain/kinetics[23]/PLA2/DAG-Ca-PLA2*/kenz ENZYME n addmsg /kinetics/chain/kinetics[23]/PLA2/APC /kinetics/chain/kinetics[23]/PLA2/DAG-Ca-PLA2*/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PLA2/PLA2-Ca*/kenz /kinetics/chain/kinetics[23]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[23]/PLA2/PIP2-PLA2*/kenz /kinetics/chain/kinetics[23]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[23]/PLA2/PIP2-Ca-PLA2*/kenz /kinetics/chain/kinetics[23]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[23]/PLA2/DAG-Ca-PLA2*/kenz /kinetics/chain/kinetics[23]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[23]/PLA2/Degrade-AA /kinetics/chain/kinetics[23]/PLA2/APC REAC B A addmsg /kinetics/chain/kinetics[23]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[23]/PLA2/APC REAC sA B addmsg /kinetics/chain/kinetics[23]/AA /kinetics/chain/kinetics[23]/PLA2/Degrade-AA SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PLA2/APC /kinetics/chain/kinetics[23]/PLA2/Degrade-AA PRODUCT n addmsg /kinetics/chain/kinetics[23]/PLA2/PLA2*-Ca/kenz /kinetics/chain/kinetics[23]/PLA2/PLA2*-Ca REAC eA B addmsg /kinetics/chain/kinetics[23]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[23]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca/diff /kinetics/chain/kinetics[23]/PLA2/PLA2*-Ca REAC B A addmsg /kinetics/chain/kinetics[23]/PLA2/APC /kinetics/chain/kinetics[23]/PLA2/PLA2*-Ca/kenz SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[23]/PLA2/PLA2*-Ca/kenz ENZYME n addmsg /kinetics/chain/kinetics[23]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[23]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[23]/PLA2/dephosphorylate-PLA2* /kinetics/chain/kinetics[23]/PLA2/PLA2* REAC A B addmsg /kinetics/chain/kinetics[23]/MAPK*/MAPK* /kinetics/chain/kinetics[23]/PLA2/PLA2* MM_PRD pA addmsg /kinetics/chain/kinetics[22]/PLA2/PLA2*/diff /kinetics/chain/kinetics[23]/PLA2/PLA2* REAC B A addmsg /kinetics/chain/kinetics[23]/PLA2/PLA2*-Ca /kinetics/chain/kinetics[23]/PLA2/PLA2*-Ca-act PRODUCT n addmsg /kinetics/chain/kinetics[23]/PLA2/PLA2* /kinetics/chain/kinetics[23]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ca /kinetics/chain/kinetics[23]/PLA2/PLA2*-Ca-act SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[23]/PLA2/dephosphorylate-PLA2* PRODUCT n addmsg /kinetics/chain/kinetics[23]/PLA2/PLA2* /kinetics/chain/kinetics[23]/PLA2/dephosphorylate-PLA2* SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PLA2/PIP2-PLA2-act /kinetics/chain/kinetics[23]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[23]/PLA2/PIP2-Ca-PLA2-act /kinetics/chain/kinetics[23]/temp-PIP2 REAC A B addmsg /kinetics/chain/kinetics[23]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[23]/MAPK/craf-1 REAC sA B addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[23]/MAPK/craf-1 MM_PRD pA addmsg /kinetics/chain/kinetics[23]/Ras-act-unphosph-raf /kinetics/chain/kinetics[23]/MAPK/craf-1 REAC A B addmsg /kinetics/chain/kinetics[23]/Ras-act-craf /kinetics/chain/kinetics[23]/MAPK/craf-1* REAC A B addmsg /kinetics/chain/kinetics[23]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[23]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[23]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[23]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[23]/MAPK/craf-1* REAC sA B addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[23]/MAPK/craf-1* MM_PRD pA addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[23]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[23]/MAPK/MAPKK REAC sA B addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[23]/MAPK/MAPKK MM_PRD pA addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[23]/MAPK/MAPK REAC sA B addmsg /kinetics/chain/kinetics[23]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[23]/MAPK/MAPK MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK/diff /kinetics/chain/kinetics[23]/MAPK/MAPK REAC B A addmsg /kinetics/chain/kinetics[23]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[23]/MAPK/craf-1** MM_PRD pA addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[23]/MAPK/craf-1** REAC sA B addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[23]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr REAC sA B addmsg /kinetics/chain/kinetics[23]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr MM_PRD pA addmsg /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr/diff /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr REAC B A addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKtyr /kinetics/chain/kinetics[23]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[23]/MAPK/MAPKK* REAC eA B addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[23]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[23]/MAPK/MAPKK* MM_PRD pA addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[23]/MAPK/MAPKK* REAC sA B addmsg /kinetics/chain/kinetics[23]/MAPK/MAPK /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKtyr SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK* /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKtyr ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKthr SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK* /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKthr ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser MM_PRD pA addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser REAC sA B addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[23]/Ras-act-unphosph-raf /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras REAC eA B addmsg /kinetics/chain/kinetics[23]/Ras-act-craf /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras REAC B A addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1 ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2 ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1* /kinetics/chain/kinetics[23]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras /kinetics/chain/kinetics[23]/Ras-act-craf PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ras/GTP-Ras /kinetics/chain/kinetics[23]/Ras-act-craf SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/inact-GEF /kinetics/chain/kinetics[23]/Ras/dephosph-GEF PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ras/GEF* /kinetics/chain/kinetics[23]/Ras/dephosph-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/dephosph-GEF /kinetics/chain/kinetics[23]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[23]/Ras/inact-GEF REAC eA B addmsg /kinetics/chain/kinetics[23]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[23]/Ras/inact-GEF REAC A B addmsg /kinetics/chain/kinetics[23]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[23]/Ras/inact-GEF REAC sA B addmsg /kinetics/chain/kinetics[22]/Ras/inact-GEF/diff /kinetics/chain/kinetics[23]/Ras/inact-GEF REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/inact-GEF /kinetics/chain/kinetics[23]/Ras/inact-GEF/basal_GEF_activity ENZYME n addmsg /kinetics/chain/kinetics[23]/Ras/GDP-Ras /kinetics/chain/kinetics[23]/Ras/inact-GEF/basal_GEF_activity SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/dephosph-GEF /kinetics/chain/kinetics[23]/Ras/GEF* REAC A B addmsg /kinetics/chain/kinetics[23]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[23]/Ras/GEF* REAC eA B addmsg /kinetics/chain/kinetics[23]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[23]/Ras/GEF* MM_PRD pA addmsg /kinetics/chain/kinetics[22]/Ras/GEF*/diff /kinetics/chain/kinetics[23]/Ras/GEF* REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/GEF* /kinetics/chain/kinetics[23]/Ras/GEF*/GEF*-act-ras ENZYME n addmsg /kinetics/chain/kinetics[23]/Ras/GDP-Ras /kinetics/chain/kinetics[23]/Ras/GEF*/GEF*-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras-act-craf /kinetics/chain/kinetics[23]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[23]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[23]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[23]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[23]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[23]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[23]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[23]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[23]/Ras/GTP-Ras REAC sA B addmsg /kinetics/chain/kinetics[23]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[23]/Ras/GTP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[23]/Ras-act-unphosph-raf /kinetics/chain/kinetics[23]/Ras/GTP-Ras REAC A B addmsg /kinetics/chain/kinetics[23]/Ras/inact-GEF/basal_GEF_activity /kinetics/chain/kinetics[23]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[23]/Ras/GEF*/GEF*-act-ras /kinetics/chain/kinetics[23]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[23]/Ras/Ras-intrinsic-GTPase /kinetics/chain/kinetics[23]/Ras/GDP-Ras REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[23]/Ras/GDP-Ras MM_PRD pA addmsg /kinetics/chain/kinetics[23]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[23]/Ras/GDP-Ras REAC sA B addmsg /kinetics/chain/kinetics[23]/Ras/GTP-Ras /kinetics/chain/kinetics[23]/Ras/Ras-intrinsic-GTPase SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/GDP-Ras /kinetics/chain/kinetics[23]/Ras/Ras-intrinsic-GTPase PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ras/GAP* /kinetics/chain/kinetics[23]/Ras/dephosph-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/GAP /kinetics/chain/kinetics[23]/Ras/dephosph-GAP PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ras/dephosph-GAP /kinetics/chain/kinetics[23]/Ras/GAP* REAC A B addmsg /kinetics/chain/kinetics[23]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[23]/Ras/GAP* MM_PRD pA addmsg /kinetics/chain/kinetics[22]/Ras/GAP*/diff /kinetics/chain/kinetics[23]/Ras/GAP* REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/dephosph-GAP /kinetics/chain/kinetics[23]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/GAP/GAP-inact-ras /kinetics/chain/kinetics[23]/Ras/GAP REAC eA B addmsg /kinetics/chain/kinetics[23]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[23]/Ras/GAP REAC sA B addmsg /kinetics/chain/kinetics[22]/Ras/GAP/diff /kinetics/chain/kinetics[23]/Ras/GAP REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/GTP-Ras /kinetics/chain/kinetics[23]/Ras/GAP/GAP-inact-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/GAP /kinetics/chain/kinetics[23]/Ras/GAP/GAP-inact-ras ENZYME n addmsg /kinetics/chain/kinetics[23]/Ras/inact-GEF /kinetics/chain/kinetics[23]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/CaM-GEF /kinetics/chain/kinetics[23]/Ras/CaM-bind-GEF PRODUCT n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca4 /kinetics/chain/kinetics[23]/Ras/CaM-bind-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[23]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/CaM-GEF/CaM-GEF-act-ras /kinetics/chain/kinetics[23]/Ras/CaM-GEF REAC eA B addmsg /kinetics/chain/kinetics[22]/Ras/CaM-GEF/diff /kinetics/chain/kinetics[23]/Ras/CaM-GEF REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/GDP-Ras /kinetics/chain/kinetics[23]/Ras/CaM-GEF/CaM-GEF-act-ras SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ras/CaM-GEF /kinetics/chain/kinetics[23]/Ras/CaM-GEF/CaM-GEF-act-ras ENZYME n addmsg /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca /kinetics/chain/kinetics[23]/Ca REAC A B addmsg /kinetics/chain/kinetics[23]/PLA2/PLA2-Ca-act /kinetics/chain/kinetics[23]/Ca REAC A B addmsg /kinetics/chain/kinetics[23]/PLA2/PLA2*-Ca-act /kinetics/chain/kinetics[23]/Ca REAC A B addmsg /kinetics/chain/kinetics[23]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[23]/Ca REAC A B addmsg /kinetics/chain/kinetics[23]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[23]/Ca REAC A B addmsg /kinetics/chain/kinetics[23]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[23]/Ca REAC A B addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[23]/Ca REAC A B addmsg /kinetics/chain/kinetics[23]/Ca_diff /kinetics/chain/kinetics[23]/Ca REAC B A addmsg /kinetics/chain/kinetics[23]/PKC/PKC-act-by-DAG /kinetics/chain/kinetics[23]/DAG REAC A B addmsg /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG /kinetics/chain/kinetics[23]/DAG REAC A B addmsg /kinetics/chain/kinetics[23]/PLA2/DAG-Ca-PLA2-act /kinetics/chain/kinetics[23]/DAG REAC A B addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG-AA* /kinetics/chain/kinetics[23]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-AA* /kinetics/chain/kinetics[23]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[23]/PKC/PKC-Ca-memb* /kinetics/chain/kinetics[23]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[23]/PKC/PKC-DAG-memb* /kinetics/chain/kinetics[23]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[23]/PKC/PKC-basal* /kinetics/chain/kinetics[23]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[23]/PKC/PKC-AA* /kinetics/chain/kinetics[23]/PKC-active SUMTOTAL n nInit addmsg /kinetics/chain/kinetics[23]/PKC-active/PKC-act-raf /kinetics/chain/kinetics[23]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[23]/PKC-active/PKC-inact-GAP /kinetics/chain/kinetics[23]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[23]/PKC-active/PKC-act-GEF /kinetics/chain/kinetics[23]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[23]/PKC-active/phosph-AC2 /kinetics/chain/kinetics[23]/PKC-active REAC eA B addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1 /kinetics/chain/kinetics[23]/PKC-active/PKC-act-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC-active /kinetics/chain/kinetics[23]/PKC-active/PKC-act-raf ENZYME n addmsg /kinetics/chain/kinetics[23]/Ras/GAP /kinetics/chain/kinetics[23]/PKC-active/PKC-inact-GAP SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC-active /kinetics/chain/kinetics[23]/PKC-active/PKC-inact-GAP ENZYME n addmsg /kinetics/chain/kinetics[23]/Ras/inact-GEF /kinetics/chain/kinetics[23]/PKC-active/PKC-act-GEF SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PKC-active /kinetics/chain/kinetics[23]/PKC-active/PKC-act-GEF ENZYME n addmsg /kinetics/chain/kinetics[23]/PKC-active /kinetics/chain/kinetics[23]/PKC-active/phosph-AC2 ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKthr /kinetics/chain/kinetics[23]/MAPK* MM_PRD pA addmsg /kinetics/chain/kinetics[23]/MAPK*/MAPK* /kinetics/chain/kinetics[23]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[23]/MAPK*/MAPK*-feedback /kinetics/chain/kinetics[23]/MAPK* REAC eA B addmsg /kinetics/chain/kinetics[23]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[23]/MAPK* REAC sA B addmsg /kinetics/chain/kinetics[22]/MAPK*/diff /kinetics/chain/kinetics[23]/MAPK* REAC B A addmsg /kinetics/chain/kinetics[23]/PLA2/PLA2-cytosolic /kinetics/chain/kinetics[23]/MAPK*/MAPK* SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK* /kinetics/chain/kinetics[23]/MAPK*/MAPK* ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1* /kinetics/chain/kinetics[23]/MAPK*/MAPK*-feedback SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK* /kinetics/chain/kinetics[23]/MAPK*/MAPK*-feedback ENZYME n addmsg /kinetics/chain/kinetics[23]/MKP-1/MKP1-tyr-deph /kinetics/chain/kinetics[23]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[23]/MKP-1/MKP1-thr-deph /kinetics/chain/kinetics[23]/MKP-1 REAC eA B addmsg /kinetics/chain/kinetics[22]/MKP-1/diff /kinetics/chain/kinetics[23]/MKP-1 REAC B A addmsg /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr /kinetics/chain/kinetics[23]/MKP-1/MKP1-tyr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MKP-1 /kinetics/chain/kinetics[23]/MKP-1/MKP1-tyr-deph ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK* /kinetics/chain/kinetics[23]/MKP-1/MKP1-thr-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MKP-1 /kinetics/chain/kinetics[23]/MKP-1/MKP1-thr-deph ENZYME n addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/craf-deph /kinetics/chain/kinetics[23]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph /kinetics/chain/kinetics[23]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph-ser /kinetics/chain/kinetics[23]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A/craf**-deph /kinetics/chain/kinetics[23]/PPhosphatase2A REAC eA B addmsg /kinetics/chain/kinetics[22]/PPhosphatase2A/diff /kinetics/chain/kinetics[23]/PPhosphatase2A REAC B A addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1* /kinetics/chain/kinetics[23]/PPhosphatase2A/craf-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A /kinetics/chain/kinetics[23]/PPhosphatase2A/craf-deph ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK* /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph-ser SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph-ser ENZYME n addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1** /kinetics/chain/kinetics[23]/PPhosphatase2A/craf**-deph SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/PPhosphatase2A /kinetics/chain/kinetics[23]/PPhosphatase2A/craf**-deph ENZYME n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[23]/CaM/CaM REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM/diff /kinetics/chain/kinetics[23]/CaM/CaM REAC B A addmsg /kinetics/chain/kinetics[23]/Ca /kinetics/chain/kinetics[23]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ca /kinetics/chain/kinetics[23]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM /kinetics/chain/kinetics[23]/CaM/CaM-TR2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[23]/CaM/CaM-TR2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ca /kinetics/chain/kinetics[23]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca3 /kinetics/chain/kinetics[23]/CaM/CaM-TR2-Ca2-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-TR2-Ca2 /kinetics/chain/kinetics[23]/CaM/CaM-TR2-Ca2-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ca /kinetics/chain/kinetics[23]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca3 /kinetics/chain/kinetics[23]/CaM/CaM-Ca3-bind-Ca SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca4 /kinetics/chain/kinetics[23]/CaM/CaM-Ca3-bind-Ca PRODUCT n addmsg /kinetics/chain/kinetics[23]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[23]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[23]/CaM/CaM-Ca3 REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca3/diff /kinetics/chain/kinetics[23]/CaM/CaM-Ca3 REAC B A addmsg /kinetics/chain/kinetics[23]/CaM/CaM-TR2-bind-Ca /kinetics/chain/kinetics[23]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[23]/CaM/CaM-TR2-Ca2-bind-Ca /kinetics/chain/kinetics[23]/CaM/CaM-TR2-Ca2 REAC A B addmsg /kinetics/chain/kinetics[22]/CaM/CaM-TR2-Ca2/diff /kinetics/chain/kinetics[23]/CaM/CaM-TR2-Ca2 REAC B A addmsg /kinetics/chain/kinetics[23]/Ras/CaM-bind-GEF /kinetics/chain/kinetics[23]/CaM/CaM-Ca4 REAC A B addmsg /kinetics/chain/kinetics[23]/CaM/CaM-Ca3-bind-Ca /kinetics/chain/kinetics[23]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[22]/CaM/CaM-Ca4/diff /kinetics/chain/kinetics[23]/CaM/CaM-Ca4 REAC B A addmsg /kinetics/chain/kinetics[23]/MAPK/craf-1 /kinetics/chain/kinetics[23]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras /kinetics/chain/kinetics[23]/Ras-act-unphosph-raf PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ras/GTP-Ras /kinetics/chain/kinetics[23]/Ras-act-unphosph-raf SUBSTRATE n addmsg /kinetics/chain/kinetics[23]/Ca_diff /kinetics/chain/kinetics[23]/Ca_input REAC A B addmsg /kinetics/chain/kinetics[23]/Ca /kinetics/chain/kinetics[23]/Ca_diff PRODUCT n addmsg /kinetics/chain/kinetics[23]/Ca_input /kinetics/chain/kinetics[23]/Ca_diff SUBSTRATE n enddump // End of dump call /kinetics/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/PKC/PKC-act-by-Ca-AA/notes LOAD \ "Schaechter and Benowitz We have to increase Kf for conc scaling" \ "Changed kf to 2e-9 on Sept 19, 94. This gives better match." \ "" call /kinetics/PKC/PKC-act-by-DAG-AA/notes LOAD \ "Assume slowish too. Schaechter and Benowitz" call /kinetics/PKC/PKC-basal-act/notes LOAD \ "Initial basal levels were set by kf = 1, kb = 20. In model, though, the" \ "basal levels of PKC activity are higher." call /kinetics/PKC/PKC-act-by-AA/notes LOAD \ "Raise kf from 1.667e-10 to 2e-10 to get better match to data." call /kinetics/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/PKC/PKC-n-DAG-AA/notes LOAD \ "Reduced kf to 0.66X to match Shinomura et al data." \ "Initial: kf = 3.3333e-9" \ "New: 2e-9" \ "Newer: 2e-8" \ "kb was 0.2" \ "now 2." call /kinetics/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/PLA2/notes LOAD \ "Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270." \ "Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see" \ "Wijkander and Sundler JBC 202 (1991) pp873-880;" \ "Diez and Mong JBC 265(24) p14654;" \ "Leslie JBC 266(17) (1991) pp11366-11371" call /kinetics/PLA2/PLA2-cytosolic/notes LOAD \ "Calculated cytosolic was 20 nm from Wijkander and Sundler" \ "However, Leslie and Channon use about 400 nM. Need to confirm," \ "but this is the value I use here. Another recalc of W&S gives 1uM" call /kinetics/PLA2/PLA2-Ca-act/notes LOAD \ "Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267." call /kinetics/PLA2/PLA2-Ca*/kenz/notes LOAD \ "10 x raise oct22" \ "12 x oct 24, set k2 = 4 * k3" call /kinetics/PLA2/PIP2-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X further raise oct 24 to allow for correct conc of enzyme" \ "" call /kinetics/PLA2/PIP2-Ca-PLA2*/kenz/notes LOAD \ "10 x raise oct 22" \ "12 x and rescale for k2 = 4 * k3 convention oct 24" \ "Increase further to get the match to expt, which was spoilt due" \ "to large accumulation of PLA2 in the enzyme complexed forms." \ "Lets raise k3, leaving the others at " \ "k1 = 1.5e-5 and k2 = 144 since they are large already." \ "" call /kinetics/PLA2/DAG-Ca-PLA2-act/notes LOAD \ "27 June 1996" \ "Scaled kf down by 0.015" \ "from 3.33e-7 to 5e-9" \ "to fit with revised DAG estimates" \ "and use of mole-fraction to calculate eff on PLA2." call /kinetics/PLA2/DAG-Ca-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X raise oct 24 + conversion to k2 =4 * k3" call /kinetics/PLA2/APC/notes LOAD \ "arachodonylphosphatidylcholine is the favoured substrate" \ "from Wijkander and Sundler, JBC 202 pp 873-880, 1991." \ "Their assay used 30 uM substrate, which is what the kinetics in" \ "this model are based on. For the later model we should locate" \ "a more realistic value for APC." call /kinetics/PLA2/Degrade-AA/notes LOAD \ "I need to check if the AA degradation pathway really leads back to " \ "APC. Anyway, it is a convenient buffered pool to dump it back into." \ "For the purposes of the full model we use a rate of degradation of" \ "0.2/sec" \ "Raised decay to 0.4 : see PLA35.g notes for Feb17 " call /kinetics/PLA2/PLA2*-Ca/notes LOAD \ "Phosphorylated form of PLA2. Still need to hook it up using kinases." \ "PKA: Wightman et al JBC 257 pp6650 1982" \ "PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal" \ "MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone" \ "Do not know if there is a Ca requirement for active phosphorylated state." call /kinetics/PLA2/PLA2*-Ca/kenz/notes LOAD \ "This form should be 3 to 6 times as fast as the Ca-only form." \ "I have scaled by 4x which seems to give a 5x rise." \ "10x raise Oct 22" \ "12 x oct 24, changed k2 = 4 * k3" call /kinetics/PLA2/PLA2*-Ca-act/notes LOAD \ "To start off, same kinetics as the PLA2-Ca-act direct pathway." \ "Oops ! Missed out the Ca input to this pathway first time round." \ "Let's raise the forward rate about 3x to 5e-6. This will let us reduce the" \ "rather high rates we have used for the kenz on PLA2*-Ca. In fact, it" \ "may be that the rates are not that different, just that this pathway for" \ "getting the PLA2 to the memb is more efficien...." call /kinetics/temp-PIP2/notes LOAD \ "This isn't explicitly present in the M&L model, but is obviously needed." \ "I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim" \ "7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) " \ "Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs," \ "which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984" \ "Lets use a lower level of 30 nM, same ref...." call /kinetics/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" \ "28 Feb 2006: Increased affinity 36-fold to account for Ca" \ "input to MAPK cascade, possibly folding in other pathway" \ "inputs." \ "21 April 2006: Altered affinity to same level as " \ "pkm_mapk21.g model to prevent spontaneous turnon." \ "Kf = 200, Kb = 1." \ "" \ "" \ "" call /kinetics/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras" \ "" call /kinetics/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/PKC-active/phosph-AC2/notes LOAD \ "Phorbol esters have little effect on AC1 or on the Gs-stimulation of" \ "AC2. So in this model we are only dealing with the increase in" \ "basal activation of AC2 induced by PKC" \ "k1 = 1.66e-6" \ "k2 = 16" \ "k3 =4" \ "" call /kinetics/MAPK*/MAPK*/notes LOAD \ "Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate)" \ "Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so:" \ "k3 = .5/sec (rate limiting)" \ "k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1" \ "#s from Sanghera et al JBC 265 pp 52 , 1990. " \ "From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio" \ "of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5" call /kinetics/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/IP3/notes LOAD \ "Peak IP3 is perhaps 15 uM, basal <= 0.2 uM." call /kinetics/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/CaM/CaM-TR2-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)...." call /kinetics/CaM/CaM-TR2-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/CaM/CaM-TR2-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics/PKC/PKC-act-by-Ca-AA/notes LOAD \ "Schaechter and Benowitz We have to increase Kf for conc scaling" \ "Changed kf to 2e-9 on Sept 19, 94. This gives better match." \ "" call /kinetics/chain/kinetics/PKC/PKC-act-by-DAG-AA/notes LOAD \ "Assume slowish too. Schaechter and Benowitz" call /kinetics/chain/kinetics/PKC/PKC-basal-act/notes LOAD \ "Initial basal levels were set by kf = 1, kb = 20. In model, though, the" \ "basal levels of PKC activity are higher." call /kinetics/chain/kinetics/PKC/PKC-act-by-AA/notes LOAD \ "Raise kf from 1.667e-10 to 2e-10 to get better match to data." call /kinetics/chain/kinetics/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics/PKC/PKC-n-DAG-AA/notes LOAD \ "Reduced kf to 0.66X to match Shinomura et al data." \ "Initial: kf = 3.3333e-9" \ "New: 2e-9" \ "Newer: 2e-8" \ "kb was 0.2" \ "now 2." call /kinetics/chain/kinetics/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics/PLA2/notes LOAD \ "Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270." \ "Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see" \ "Wijkander and Sundler JBC 202 (1991) pp873-880;" \ "Diez and Mong JBC 265(24) p14654;" \ "Leslie JBC 266(17) (1991) pp11366-11371" call /kinetics/chain/kinetics/PLA2/PLA2-cytosolic/notes LOAD \ "Calculated cytosolic was 20 nm from Wijkander and Sundler" \ "However, Leslie and Channon use about 400 nM. Need to confirm," \ "but this is the value I use here. Another recalc of W&S gives 1uM" call /kinetics/chain/kinetics/PLA2/PLA2-Ca-act/notes LOAD \ "Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267." call /kinetics/chain/kinetics/PLA2/PLA2-Ca*/kenz/notes LOAD \ "10 x raise oct22" \ "12 x oct 24, set k2 = 4 * k3" call /kinetics/chain/kinetics/PLA2/PIP2-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X further raise oct 24 to allow for correct conc of enzyme" \ "" call /kinetics/chain/kinetics/PLA2/PIP2-Ca-PLA2*/kenz/notes LOAD \ "10 x raise oct 22" \ "12 x and rescale for k2 = 4 * k3 convention oct 24" \ "Increase further to get the match to expt, which was spoilt due" \ "to large accumulation of PLA2 in the enzyme complexed forms." \ "Lets raise k3, leaving the others at " \ "k1 = 1.5e-5 and k2 = 144 since they are large already." \ "" call /kinetics/chain/kinetics/PLA2/DAG-Ca-PLA2-act/notes LOAD \ "27 June 1996" \ "Scaled kf down by 0.015" \ "from 3.33e-7 to 5e-9" \ "to fit with revised DAG estimates" \ "and use of mole-fraction to calculate eff on PLA2." call /kinetics/chain/kinetics/PLA2/DAG-Ca-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X raise oct 24 + conversion to k2 =4 * k3" call /kinetics/chain/kinetics/PLA2/APC/notes LOAD \ "arachodonylphosphatidylcholine is the favoured substrate" \ "from Wijkander and Sundler, JBC 202 pp 873-880, 1991." \ "Their assay used 30 uM substrate, which is what the kinetics in" \ "this model are based on. For the later model we should locate" \ "a more realistic value for APC." call /kinetics/chain/kinetics/PLA2/Degrade-AA/notes LOAD \ "I need to check if the AA degradation pathway really leads back to " \ "APC. Anyway, it is a convenient buffered pool to dump it back into." \ "For the purposes of the full model we use a rate of degradation of" \ "0.2/sec" \ "Raised decay to 0.4 : see PLA35.g notes for Feb17 " call /kinetics/chain/kinetics/PLA2/PLA2*-Ca/notes LOAD \ "Phosphorylated form of PLA2. Still need to hook it up using kinases." \ "PKA: Wightman et al JBC 257 pp6650 1982" \ "PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal" \ "MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone" \ "Do not know if there is a Ca requirement for active phosphorylated state." call /kinetics/chain/kinetics/PLA2/PLA2*-Ca/kenz/notes LOAD \ "This form should be 3 to 6 times as fast as the Ca-only form." \ "I have scaled by 4x which seems to give a 5x rise." \ "10x raise Oct 22" \ "12 x oct 24, changed k2 = 4 * k3" call /kinetics/chain/kinetics/PLA2/PLA2*-Ca-act/notes LOAD \ "To start off, same kinetics as the PLA2-Ca-act direct pathway." \ "Oops ! Missed out the Ca input to this pathway first time round." \ "Let's raise the forward rate about 3x to 5e-6. This will let us reduce the" \ "rather high rates we have used for the kenz on PLA2*-Ca. In fact, it" \ "may be that the rates are not that different, just that this pathway for" \ "getting the PLA2 to the memb is more efficien...." call /kinetics/chain/kinetics/temp-PIP2/notes LOAD \ "This isn't explicitly present in the M&L model, but is obviously needed." \ "I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim" \ "7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) " \ "Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs," \ "which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984" \ "Lets use a lower level of 30 nM, same ref...." call /kinetics/chain/kinetics/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" \ "28 Feb 2006: Increased affinity 36-fold to account for Ca" \ "input to MAPK cascade, possibly folding in other pathway" \ "inputs." \ "21 April 2006: Altered affinity to same level as " \ "pkm_mapk21.g model to prevent spontaneous turnon." \ "Kf = 200, Kb = 1." \ "" \ "" \ "" call /kinetics/chain/kinetics/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras" \ "" call /kinetics/chain/kinetics/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics/PKC-active/phosph-AC2/notes LOAD \ "Phorbol esters have little effect on AC1 or on the Gs-stimulation of" \ "AC2. So in this model we are only dealing with the increase in" \ "basal activation of AC2 induced by PKC" \ "k1 = 1.66e-6" \ "k2 = 16" \ "k3 =4" \ "" call /kinetics/chain/kinetics/MAPK*/MAPK*/notes LOAD \ "Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate)" \ "Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so:" \ "k3 = .5/sec (rate limiting)" \ "k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1" \ "#s from Sanghera et al JBC 265 pp 52 , 1990. " \ "From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio" \ "of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5" call /kinetics/chain/kinetics/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics/IP3/notes LOAD \ "Peak IP3 is perhaps 15 uM, basal <= 0.2 uM." call /kinetics/chain/kinetics/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics/CaM/CaM-TR2-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)...." call /kinetics/chain/kinetics/CaM/CaM-TR2-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics/CaM/CaM-TR2-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[1]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[1]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[1]/PKC/PKC-act-by-Ca-AA/notes LOAD \ "Schaechter and Benowitz We have to increase Kf for conc scaling" \ "Changed kf to 2e-9 on Sept 19, 94. This gives better match." \ "" call /kinetics/chain/kinetics[1]/PKC/PKC-act-by-DAG-AA/notes LOAD \ "Assume slowish too. Schaechter and Benowitz" call /kinetics/chain/kinetics[1]/PKC/PKC-basal-act/notes LOAD \ "Initial basal levels were set by kf = 1, kb = 20. In model, though, the" \ "basal levels of PKC activity are higher." call /kinetics/chain/kinetics[1]/PKC/PKC-act-by-AA/notes LOAD \ "Raise kf from 1.667e-10 to 2e-10 to get better match to data." call /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[1]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[1]/PKC/PKC-n-DAG-AA/notes LOAD \ "Reduced kf to 0.66X to match Shinomura et al data." \ "Initial: kf = 3.3333e-9" \ "New: 2e-9" \ "Newer: 2e-8" \ "kb was 0.2" \ "now 2." call /kinetics/chain/kinetics[1]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[1]/PLA2/notes LOAD \ "Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270." \ "Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see" \ "Wijkander and Sundler JBC 202 (1991) pp873-880;" \ "Diez and Mong JBC 265(24) p14654;" \ "Leslie JBC 266(17) (1991) pp11366-11371" call /kinetics/chain/kinetics[1]/PLA2/PLA2-cytosolic/notes LOAD \ "Calculated cytosolic was 20 nm from Wijkander and Sundler" \ "However, Leslie and Channon use about 400 nM. Need to confirm," \ "but this is the value I use here. Another recalc of W&S gives 1uM" call /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca-act/notes LOAD \ "Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267." call /kinetics/chain/kinetics[1]/PLA2/PLA2-Ca*/kenz/notes LOAD \ "10 x raise oct22" \ "12 x oct 24, set k2 = 4 * k3" call /kinetics/chain/kinetics[1]/PLA2/PIP2-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X further raise oct 24 to allow for correct conc of enzyme" \ "" call /kinetics/chain/kinetics[1]/PLA2/PIP2-Ca-PLA2*/kenz/notes LOAD \ "10 x raise oct 22" \ "12 x and rescale for k2 = 4 * k3 convention oct 24" \ "Increase further to get the match to expt, which was spoilt due" \ "to large accumulation of PLA2 in the enzyme complexed forms." \ "Lets raise k3, leaving the others at " \ "k1 = 1.5e-5 and k2 = 144 since they are large already." \ "" call /kinetics/chain/kinetics[1]/PLA2/DAG-Ca-PLA2-act/notes LOAD \ "27 June 1996" \ "Scaled kf down by 0.015" \ "from 3.33e-7 to 5e-9" \ "to fit with revised DAG estimates" \ "and use of mole-fraction to calculate eff on PLA2." call /kinetics/chain/kinetics[1]/PLA2/DAG-Ca-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X raise oct 24 + conversion to k2 =4 * k3" call /kinetics/chain/kinetics[1]/PLA2/APC/notes LOAD \ "arachodonylphosphatidylcholine is the favoured substrate" \ "from Wijkander and Sundler, JBC 202 pp 873-880, 1991." \ "Their assay used 30 uM substrate, which is what the kinetics in" \ "this model are based on. For the later model we should locate" \ "a more realistic value for APC." call /kinetics/chain/kinetics[1]/PLA2/Degrade-AA/notes LOAD \ "I need to check if the AA degradation pathway really leads back to " \ "APC. Anyway, it is a convenient buffered pool to dump it back into." \ "For the purposes of the full model we use a rate of degradation of" \ "0.2/sec" \ "Raised decay to 0.4 : see PLA35.g notes for Feb17 " call /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca/notes LOAD \ "Phosphorylated form of PLA2. Still need to hook it up using kinases." \ "PKA: Wightman et al JBC 257 pp6650 1982" \ "PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal" \ "MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone" \ "Do not know if there is a Ca requirement for active phosphorylated state." call /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca/kenz/notes LOAD \ "This form should be 3 to 6 times as fast as the Ca-only form." \ "I have scaled by 4x which seems to give a 5x rise." \ "10x raise Oct 22" \ "12 x oct 24, changed k2 = 4 * k3" call /kinetics/chain/kinetics[1]/PLA2/PLA2*-Ca-act/notes LOAD \ "To start off, same kinetics as the PLA2-Ca-act direct pathway." \ "Oops ! Missed out the Ca input to this pathway first time round." \ "Let's raise the forward rate about 3x to 5e-6. This will let us reduce the" \ "rather high rates we have used for the kenz on PLA2*-Ca. In fact, it" \ "may be that the rates are not that different, just that this pathway for" \ "getting the PLA2 to the memb is more efficien...." call /kinetics/chain/kinetics[1]/temp-PIP2/notes LOAD \ "This isn't explicitly present in the M&L model, but is obviously needed." \ "I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim" \ "7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) " \ "Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs," \ "which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984" \ "Lets use a lower level of 30 nM, same ref...." call /kinetics/chain/kinetics[1]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[1]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[1]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[1]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[1]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[1]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[1]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[1]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[1]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[1]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[1]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[1]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[1]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[1]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[1]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[1]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[1]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[1]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[1]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[1]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[1]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[1]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" \ "28 Feb 2006: Increased affinity 36-fold to account for Ca" \ "input to MAPK cascade, possibly folding in other pathway" \ "inputs." \ "21 April 2006: Altered affinity to same level as " \ "pkm_mapk21.g model to prevent spontaneous turnon." \ "Kf = 200, Kb = 1." \ "" \ "" \ "" call /kinetics/chain/kinetics[1]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[1]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras" \ "" call /kinetics/chain/kinetics[1]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[1]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[1]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[1]/PKC-active/phosph-AC2/notes LOAD \ "Phorbol esters have little effect on AC1 or on the Gs-stimulation of" \ "AC2. So in this model we are only dealing with the increase in" \ "basal activation of AC2 induced by PKC" \ "k1 = 1.66e-6" \ "k2 = 16" \ "k3 =4" \ "" call /kinetics/chain/kinetics[1]/MAPK*/MAPK*/notes LOAD \ "Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate)" \ "Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so:" \ "k3 = .5/sec (rate limiting)" \ "k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1" \ "#s from Sanghera et al JBC 265 pp 52 , 1990. " \ "From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio" \ "of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5" call /kinetics/chain/kinetics[1]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[1]/IP3/notes LOAD \ "Peak IP3 is perhaps 15 uM, basal <= 0.2 uM." call /kinetics/chain/kinetics[1]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[1]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[1]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[1]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[1]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[1]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[1]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[1]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[1]/CaM/CaM-TR2-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)...." call /kinetics/chain/kinetics[1]/CaM/CaM-TR2-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[1]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[1]/CaM/CaM-TR2-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[1]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[2]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[2]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[2]/PKC/PKC-act-by-Ca-AA/notes LOAD \ "Schaechter and Benowitz We have to increase Kf for conc scaling" \ "Changed kf to 2e-9 on Sept 19, 94. This gives better match." \ "" call /kinetics/chain/kinetics[2]/PKC/PKC-act-by-DAG-AA/notes LOAD \ "Assume slowish too. Schaechter and Benowitz" call /kinetics/chain/kinetics[2]/PKC/PKC-basal-act/notes LOAD \ "Initial basal levels were set by kf = 1, kb = 20. In model, though, the" \ "basal levels of PKC activity are higher." call /kinetics/chain/kinetics[2]/PKC/PKC-act-by-AA/notes LOAD \ "Raise kf from 1.667e-10 to 2e-10 to get better match to data." call /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[2]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[2]/PKC/PKC-n-DAG-AA/notes LOAD \ "Reduced kf to 0.66X to match Shinomura et al data." \ "Initial: kf = 3.3333e-9" \ "New: 2e-9" \ "Newer: 2e-8" \ "kb was 0.2" \ "now 2." call /kinetics/chain/kinetics[2]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[2]/PLA2/notes LOAD \ "Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270." \ "Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see" \ "Wijkander and Sundler JBC 202 (1991) pp873-880;" \ "Diez and Mong JBC 265(24) p14654;" \ "Leslie JBC 266(17) (1991) pp11366-11371" call /kinetics/chain/kinetics[2]/PLA2/PLA2-cytosolic/notes LOAD \ "Calculated cytosolic was 20 nm from Wijkander and Sundler" \ "However, Leslie and Channon use about 400 nM. Need to confirm," \ "but this is the value I use here. Another recalc of W&S gives 1uM" call /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca-act/notes LOAD \ "Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267." call /kinetics/chain/kinetics[2]/PLA2/PLA2-Ca*/kenz/notes LOAD \ "10 x raise oct22" \ "12 x oct 24, set k2 = 4 * k3" call /kinetics/chain/kinetics[2]/PLA2/PIP2-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X further raise oct 24 to allow for correct conc of enzyme" \ "" call /kinetics/chain/kinetics[2]/PLA2/PIP2-Ca-PLA2*/kenz/notes LOAD \ "10 x raise oct 22" \ "12 x and rescale for k2 = 4 * k3 convention oct 24" \ "Increase further to get the match to expt, which was spoilt due" \ "to large accumulation of PLA2 in the enzyme complexed forms." \ "Lets raise k3, leaving the others at " \ "k1 = 1.5e-5 and k2 = 144 since they are large already." \ "" call /kinetics/chain/kinetics[2]/PLA2/DAG-Ca-PLA2-act/notes LOAD \ "27 June 1996" \ "Scaled kf down by 0.015" \ "from 3.33e-7 to 5e-9" \ "to fit with revised DAG estimates" \ "and use of mole-fraction to calculate eff on PLA2." call /kinetics/chain/kinetics[2]/PLA2/DAG-Ca-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X raise oct 24 + conversion to k2 =4 * k3" call /kinetics/chain/kinetics[2]/PLA2/APC/notes LOAD \ "arachodonylphosphatidylcholine is the favoured substrate" \ "from Wijkander and Sundler, JBC 202 pp 873-880, 1991." \ "Their assay used 30 uM substrate, which is what the kinetics in" \ "this model are based on. For the later model we should locate" \ "a more realistic value for APC." call /kinetics/chain/kinetics[2]/PLA2/Degrade-AA/notes LOAD \ "I need to check if the AA degradation pathway really leads back to " \ "APC. Anyway, it is a convenient buffered pool to dump it back into." \ "For the purposes of the full model we use a rate of degradation of" \ "0.2/sec" \ "Raised decay to 0.4 : see PLA35.g notes for Feb17 " call /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca/notes LOAD \ "Phosphorylated form of PLA2. Still need to hook it up using kinases." \ "PKA: Wightman et al JBC 257 pp6650 1982" \ "PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal" \ "MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone" \ "Do not know if there is a Ca requirement for active phosphorylated state." call /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca/kenz/notes LOAD \ "This form should be 3 to 6 times as fast as the Ca-only form." \ "I have scaled by 4x which seems to give a 5x rise." \ "10x raise Oct 22" \ "12 x oct 24, changed k2 = 4 * k3" call /kinetics/chain/kinetics[2]/PLA2/PLA2*-Ca-act/notes LOAD \ "To start off, same kinetics as the PLA2-Ca-act direct pathway." \ "Oops ! Missed out the Ca input to this pathway first time round." \ "Let's raise the forward rate about 3x to 5e-6. This will let us reduce the" \ "rather high rates we have used for the kenz on PLA2*-Ca. In fact, it" \ "may be that the rates are not that different, just that this pathway for" \ "getting the PLA2 to the memb is more efficien...." call /kinetics/chain/kinetics[2]/temp-PIP2/notes LOAD \ "This isn't explicitly present in the M&L model, but is obviously needed." \ "I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim" \ "7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) " \ "Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs," \ "which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984" \ "Lets use a lower level of 30 nM, same ref...." call /kinetics/chain/kinetics[2]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[2]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[2]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[2]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[2]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[2]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[2]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[2]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[2]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[2]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[2]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[2]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[2]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[2]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[2]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[2]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[2]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[2]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[2]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[2]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[2]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[2]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" \ "28 Feb 2006: Increased affinity 36-fold to account for Ca" \ "input to MAPK cascade, possibly folding in other pathway" \ "inputs." \ "21 April 2006: Altered affinity to same level as " \ "pkm_mapk21.g model to prevent spontaneous turnon." \ "Kf = 200, Kb = 1." \ "" \ "" \ "" call /kinetics/chain/kinetics[2]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[2]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras" \ "" call /kinetics/chain/kinetics[2]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[2]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[2]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[2]/PKC-active/phosph-AC2/notes LOAD \ "Phorbol esters have little effect on AC1 or on the Gs-stimulation of" \ "AC2. So in this model we are only dealing with the increase in" \ "basal activation of AC2 induced by PKC" \ "k1 = 1.66e-6" \ "k2 = 16" \ "k3 =4" \ "" call /kinetics/chain/kinetics[2]/MAPK*/MAPK*/notes LOAD \ "Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate)" \ "Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so:" \ "k3 = .5/sec (rate limiting)" \ "k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1" \ "#s from Sanghera et al JBC 265 pp 52 , 1990. " \ "From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio" \ "of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5" call /kinetics/chain/kinetics[2]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[2]/IP3/notes LOAD \ "Peak IP3 is perhaps 15 uM, basal <= 0.2 uM." call /kinetics/chain/kinetics[2]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[2]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[2]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[2]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[2]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[2]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[2]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[2]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[2]/CaM/CaM-TR2-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)...." call /kinetics/chain/kinetics[2]/CaM/CaM-TR2-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[2]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[2]/CaM/CaM-TR2-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[2]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[3]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[3]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[3]/PKC/PKC-act-by-Ca-AA/notes LOAD \ "Schaechter and Benowitz We have to increase Kf for conc scaling" \ "Changed kf to 2e-9 on Sept 19, 94. This gives better match." \ "" call /kinetics/chain/kinetics[3]/PKC/PKC-act-by-DAG-AA/notes LOAD \ "Assume slowish too. Schaechter and Benowitz" call /kinetics/chain/kinetics[3]/PKC/PKC-basal-act/notes LOAD \ "Initial basal levels were set by kf = 1, kb = 20. In model, though, the" \ "basal levels of PKC activity are higher." call /kinetics/chain/kinetics[3]/PKC/PKC-act-by-AA/notes LOAD \ "Raise kf from 1.667e-10 to 2e-10 to get better match to data." call /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[3]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[3]/PKC/PKC-n-DAG-AA/notes LOAD \ "Reduced kf to 0.66X to match Shinomura et al data." \ "Initial: kf = 3.3333e-9" \ "New: 2e-9" \ "Newer: 2e-8" \ "kb was 0.2" \ "now 2." call /kinetics/chain/kinetics[3]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[3]/PLA2/notes LOAD \ "Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270." \ "Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see" \ "Wijkander and Sundler JBC 202 (1991) pp873-880;" \ "Diez and Mong JBC 265(24) p14654;" \ "Leslie JBC 266(17) (1991) pp11366-11371" call /kinetics/chain/kinetics[3]/PLA2/PLA2-cytosolic/notes LOAD \ "Calculated cytosolic was 20 nm from Wijkander and Sundler" \ "However, Leslie and Channon use about 400 nM. Need to confirm," \ "but this is the value I use here. Another recalc of W&S gives 1uM" call /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca-act/notes LOAD \ "Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267." call /kinetics/chain/kinetics[3]/PLA2/PLA2-Ca*/kenz/notes LOAD \ "10 x raise oct22" \ "12 x oct 24, set k2 = 4 * k3" call /kinetics/chain/kinetics[3]/PLA2/PIP2-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X further raise oct 24 to allow for correct conc of enzyme" \ "" call /kinetics/chain/kinetics[3]/PLA2/PIP2-Ca-PLA2*/kenz/notes LOAD \ "10 x raise oct 22" \ "12 x and rescale for k2 = 4 * k3 convention oct 24" \ "Increase further to get the match to expt, which was spoilt due" \ "to large accumulation of PLA2 in the enzyme complexed forms." \ "Lets raise k3, leaving the others at " \ "k1 = 1.5e-5 and k2 = 144 since they are large already." \ "" call /kinetics/chain/kinetics[3]/PLA2/DAG-Ca-PLA2-act/notes LOAD \ "27 June 1996" \ "Scaled kf down by 0.015" \ "from 3.33e-7 to 5e-9" \ "to fit with revised DAG estimates" \ "and use of mole-fraction to calculate eff on PLA2." call /kinetics/chain/kinetics[3]/PLA2/DAG-Ca-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X raise oct 24 + conversion to k2 =4 * k3" call /kinetics/chain/kinetics[3]/PLA2/APC/notes LOAD \ "arachodonylphosphatidylcholine is the favoured substrate" \ "from Wijkander and Sundler, JBC 202 pp 873-880, 1991." \ "Their assay used 30 uM substrate, which is what the kinetics in" \ "this model are based on. For the later model we should locate" \ "a more realistic value for APC." call /kinetics/chain/kinetics[3]/PLA2/Degrade-AA/notes LOAD \ "I need to check if the AA degradation pathway really leads back to " \ "APC. Anyway, it is a convenient buffered pool to dump it back into." \ "For the purposes of the full model we use a rate of degradation of" \ "0.2/sec" \ "Raised decay to 0.4 : see PLA35.g notes for Feb17 " call /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca/notes LOAD \ "Phosphorylated form of PLA2. Still need to hook it up using kinases." \ "PKA: Wightman et al JBC 257 pp6650 1982" \ "PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal" \ "MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone" \ "Do not know if there is a Ca requirement for active phosphorylated state." call /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca/kenz/notes LOAD \ "This form should be 3 to 6 times as fast as the Ca-only form." \ "I have scaled by 4x which seems to give a 5x rise." \ "10x raise Oct 22" \ "12 x oct 24, changed k2 = 4 * k3" call /kinetics/chain/kinetics[3]/PLA2/PLA2*-Ca-act/notes LOAD \ "To start off, same kinetics as the PLA2-Ca-act direct pathway." \ "Oops ! Missed out the Ca input to this pathway first time round." \ "Let's raise the forward rate about 3x to 5e-6. This will let us reduce the" \ "rather high rates we have used for the kenz on PLA2*-Ca. In fact, it" \ "may be that the rates are not that different, just that this pathway for" \ "getting the PLA2 to the memb is more efficien...." call /kinetics/chain/kinetics[3]/temp-PIP2/notes LOAD \ "This isn't explicitly present in the M&L model, but is obviously needed." \ "I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim" \ "7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) " \ "Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs," \ "which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984" \ "Lets use a lower level of 30 nM, same ref...." call /kinetics/chain/kinetics[3]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[3]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[3]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[3]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[3]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[3]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[3]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[3]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[3]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[3]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[3]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[3]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[3]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[3]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[3]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[3]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[3]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[3]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[3]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[3]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[3]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[3]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" \ "28 Feb 2006: Increased affinity 36-fold to account for Ca" \ "input to MAPK cascade, possibly folding in other pathway" \ "inputs." \ "21 April 2006: Altered affinity to same level as " \ "pkm_mapk21.g model to prevent spontaneous turnon." \ "Kf = 200, Kb = 1." \ "" \ "" \ "" call /kinetics/chain/kinetics[3]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[3]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras" \ "" call /kinetics/chain/kinetics[3]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[3]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[3]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[3]/PKC-active/phosph-AC2/notes LOAD \ "Phorbol esters have little effect on AC1 or on the Gs-stimulation of" \ "AC2. So in this model we are only dealing with the increase in" \ "basal activation of AC2 induced by PKC" \ "k1 = 1.66e-6" \ "k2 = 16" \ "k3 =4" \ "" call /kinetics/chain/kinetics[3]/MAPK*/MAPK*/notes LOAD \ "Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate)" \ "Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so:" \ "k3 = .5/sec (rate limiting)" \ "k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1" \ "#s from Sanghera et al JBC 265 pp 52 , 1990. " \ "From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio" \ "of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5" call /kinetics/chain/kinetics[3]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[3]/IP3/notes LOAD \ "Peak IP3 is perhaps 15 uM, basal <= 0.2 uM." call /kinetics/chain/kinetics[3]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[3]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[3]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[3]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[3]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[3]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[3]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[3]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[3]/CaM/CaM-TR2-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)...." call /kinetics/chain/kinetics[3]/CaM/CaM-TR2-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[3]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[3]/CaM/CaM-TR2-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[3]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[4]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[4]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[4]/PKC/PKC-act-by-Ca-AA/notes LOAD \ "Schaechter and Benowitz We have to increase Kf for conc scaling" \ "Changed kf to 2e-9 on Sept 19, 94. This gives better match." \ "" call /kinetics/chain/kinetics[4]/PKC/PKC-act-by-DAG-AA/notes LOAD \ "Assume slowish too. Schaechter and Benowitz" call /kinetics/chain/kinetics[4]/PKC/PKC-basal-act/notes LOAD \ "Initial basal levels were set by kf = 1, kb = 20. In model, though, the" \ "basal levels of PKC activity are higher." call /kinetics/chain/kinetics[4]/PKC/PKC-act-by-AA/notes LOAD \ "Raise kf from 1.667e-10 to 2e-10 to get better match to data." call /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[4]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[4]/PKC/PKC-n-DAG-AA/notes LOAD \ "Reduced kf to 0.66X to match Shinomura et al data." \ "Initial: kf = 3.3333e-9" \ "New: 2e-9" \ "Newer: 2e-8" \ "kb was 0.2" \ "now 2." call /kinetics/chain/kinetics[4]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[4]/PLA2/notes LOAD \ "Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270." \ "Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see" \ "Wijkander and Sundler JBC 202 (1991) pp873-880;" \ "Diez and Mong JBC 265(24) p14654;" \ "Leslie JBC 266(17) (1991) pp11366-11371" call /kinetics/chain/kinetics[4]/PLA2/PLA2-cytosolic/notes LOAD \ "Calculated cytosolic was 20 nm from Wijkander and Sundler" \ "However, Leslie and Channon use about 400 nM. Need to confirm," \ "but this is the value I use here. Another recalc of W&S gives 1uM" call /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca-act/notes LOAD \ "Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267." call /kinetics/chain/kinetics[4]/PLA2/PLA2-Ca*/kenz/notes LOAD \ "10 x raise oct22" \ "12 x oct 24, set k2 = 4 * k3" call /kinetics/chain/kinetics[4]/PLA2/PIP2-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X further raise oct 24 to allow for correct conc of enzyme" \ "" call /kinetics/chain/kinetics[4]/PLA2/PIP2-Ca-PLA2*/kenz/notes LOAD \ "10 x raise oct 22" \ "12 x and rescale for k2 = 4 * k3 convention oct 24" \ "Increase further to get the match to expt, which was spoilt due" \ "to large accumulation of PLA2 in the enzyme complexed forms." \ "Lets raise k3, leaving the others at " \ "k1 = 1.5e-5 and k2 = 144 since they are large already." \ "" call /kinetics/chain/kinetics[4]/PLA2/DAG-Ca-PLA2-act/notes LOAD \ "27 June 1996" \ "Scaled kf down by 0.015" \ "from 3.33e-7 to 5e-9" \ "to fit with revised DAG estimates" \ "and use of mole-fraction to calculate eff on PLA2." call /kinetics/chain/kinetics[4]/PLA2/DAG-Ca-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X raise oct 24 + conversion to k2 =4 * k3" call /kinetics/chain/kinetics[4]/PLA2/APC/notes LOAD \ "arachodonylphosphatidylcholine is the favoured substrate" \ "from Wijkander and Sundler, JBC 202 pp 873-880, 1991." \ "Their assay used 30 uM substrate, which is what the kinetics in" \ "this model are based on. For the later model we should locate" \ "a more realistic value for APC." call /kinetics/chain/kinetics[4]/PLA2/Degrade-AA/notes LOAD \ "I need to check if the AA degradation pathway really leads back to " \ "APC. Anyway, it is a convenient buffered pool to dump it back into." \ "For the purposes of the full model we use a rate of degradation of" \ "0.2/sec" \ "Raised decay to 0.4 : see PLA35.g notes for Feb17 " call /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca/notes LOAD \ "Phosphorylated form of PLA2. Still need to hook it up using kinases." \ "PKA: Wightman et al JBC 257 pp6650 1982" \ "PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal" \ "MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone" \ "Do not know if there is a Ca requirement for active phosphorylated state." call /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca/kenz/notes LOAD \ "This form should be 3 to 6 times as fast as the Ca-only form." \ "I have scaled by 4x which seems to give a 5x rise." \ "10x raise Oct 22" \ "12 x oct 24, changed k2 = 4 * k3" call /kinetics/chain/kinetics[4]/PLA2/PLA2*-Ca-act/notes LOAD \ "To start off, same kinetics as the PLA2-Ca-act direct pathway." \ "Oops ! Missed out the Ca input to this pathway first time round." \ "Let's raise the forward rate about 3x to 5e-6. This will let us reduce the" \ "rather high rates we have used for the kenz on PLA2*-Ca. In fact, it" \ "may be that the rates are not that different, just that this pathway for" \ "getting the PLA2 to the memb is more efficien...." call /kinetics/chain/kinetics[4]/temp-PIP2/notes LOAD \ "This isn't explicitly present in the M&L model, but is obviously needed." \ "I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim" \ "7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) " \ "Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs," \ "which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984" \ "Lets use a lower level of 30 nM, same ref...." call /kinetics/chain/kinetics[4]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[4]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[4]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[4]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[4]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[4]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[4]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[4]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[4]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[4]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[4]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[4]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[4]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[4]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[4]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[4]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[4]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[4]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[4]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[4]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[4]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[4]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" \ "28 Feb 2006: Increased affinity 36-fold to account for Ca" \ "input to MAPK cascade, possibly folding in other pathway" \ "inputs." \ "21 April 2006: Altered affinity to same level as " \ "pkm_mapk21.g model to prevent spontaneous turnon." \ "Kf = 200, Kb = 1." \ "" \ "" \ "" call /kinetics/chain/kinetics[4]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[4]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras" \ "" call /kinetics/chain/kinetics[4]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[4]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[4]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[4]/PKC-active/phosph-AC2/notes LOAD \ "Phorbol esters have little effect on AC1 or on the Gs-stimulation of" \ "AC2. So in this model we are only dealing with the increase in" \ "basal activation of AC2 induced by PKC" \ "k1 = 1.66e-6" \ "k2 = 16" \ "k3 =4" \ "" call /kinetics/chain/kinetics[4]/MAPK*/MAPK*/notes LOAD \ "Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate)" \ "Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so:" \ "k3 = .5/sec (rate limiting)" \ "k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1" \ "#s from Sanghera et al JBC 265 pp 52 , 1990. " \ "From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio" \ "of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5" call /kinetics/chain/kinetics[4]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[4]/IP3/notes LOAD \ "Peak IP3 is perhaps 15 uM, basal <= 0.2 uM." call /kinetics/chain/kinetics[4]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[4]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[4]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[4]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[4]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[4]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[4]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[4]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[4]/CaM/CaM-TR2-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)...." call /kinetics/chain/kinetics[4]/CaM/CaM-TR2-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[4]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[4]/CaM/CaM-TR2-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[4]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[5]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[5]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[5]/PKC/PKC-act-by-Ca-AA/notes LOAD \ "Schaechter and Benowitz We have to increase Kf for conc scaling" \ "Changed kf to 2e-9 on Sept 19, 94. This gives better match." \ "" call /kinetics/chain/kinetics[5]/PKC/PKC-act-by-DAG-AA/notes LOAD \ "Assume slowish too. Schaechter and Benowitz" call /kinetics/chain/kinetics[5]/PKC/PKC-basal-act/notes LOAD \ "Initial basal levels were set by kf = 1, kb = 20. In model, though, the" \ "basal levels of PKC activity are higher." call /kinetics/chain/kinetics[5]/PKC/PKC-act-by-AA/notes LOAD \ "Raise kf from 1.667e-10 to 2e-10 to get better match to data." call /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[5]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[5]/PKC/PKC-n-DAG-AA/notes LOAD \ "Reduced kf to 0.66X to match Shinomura et al data." \ "Initial: kf = 3.3333e-9" \ "New: 2e-9" \ "Newer: 2e-8" \ "kb was 0.2" \ "now 2." call /kinetics/chain/kinetics[5]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[5]/PLA2/notes LOAD \ "Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270." \ "Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see" \ "Wijkander and Sundler JBC 202 (1991) pp873-880;" \ "Diez and Mong JBC 265(24) p14654;" \ "Leslie JBC 266(17) (1991) pp11366-11371" call /kinetics/chain/kinetics[5]/PLA2/PLA2-cytosolic/notes LOAD \ "Calculated cytosolic was 20 nm from Wijkander and Sundler" \ "However, Leslie and Channon use about 400 nM. Need to confirm," \ "but this is the value I use here. Another recalc of W&S gives 1uM" call /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca-act/notes LOAD \ "Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267." call /kinetics/chain/kinetics[5]/PLA2/PLA2-Ca*/kenz/notes LOAD \ "10 x raise oct22" \ "12 x oct 24, set k2 = 4 * k3" call /kinetics/chain/kinetics[5]/PLA2/PIP2-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X further raise oct 24 to allow for correct conc of enzyme" \ "" call /kinetics/chain/kinetics[5]/PLA2/PIP2-Ca-PLA2*/kenz/notes LOAD \ "10 x raise oct 22" \ "12 x and rescale for k2 = 4 * k3 convention oct 24" \ "Increase further to get the match to expt, which was spoilt due" \ "to large accumulation of PLA2 in the enzyme complexed forms." \ "Lets raise k3, leaving the others at " \ "k1 = 1.5e-5 and k2 = 144 since they are large already." \ "" call /kinetics/chain/kinetics[5]/PLA2/DAG-Ca-PLA2-act/notes LOAD \ "27 June 1996" \ "Scaled kf down by 0.015" \ "from 3.33e-7 to 5e-9" \ "to fit with revised DAG estimates" \ "and use of mole-fraction to calculate eff on PLA2." call /kinetics/chain/kinetics[5]/PLA2/DAG-Ca-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X raise oct 24 + conversion to k2 =4 * k3" call /kinetics/chain/kinetics[5]/PLA2/APC/notes LOAD \ "arachodonylphosphatidylcholine is the favoured substrate" \ "from Wijkander and Sundler, JBC 202 pp 873-880, 1991." \ "Their assay used 30 uM substrate, which is what the kinetics in" \ "this model are based on. For the later model we should locate" \ "a more realistic value for APC." call /kinetics/chain/kinetics[5]/PLA2/Degrade-AA/notes LOAD \ "I need to check if the AA degradation pathway really leads back to " \ "APC. Anyway, it is a convenient buffered pool to dump it back into." \ "For the purposes of the full model we use a rate of degradation of" \ "0.2/sec" \ "Raised decay to 0.4 : see PLA35.g notes for Feb17 " call /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca/notes LOAD \ "Phosphorylated form of PLA2. Still need to hook it up using kinases." \ "PKA: Wightman et al JBC 257 pp6650 1982" \ "PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal" \ "MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone" \ "Do not know if there is a Ca requirement for active phosphorylated state." call /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca/kenz/notes LOAD \ "This form should be 3 to 6 times as fast as the Ca-only form." \ "I have scaled by 4x which seems to give a 5x rise." \ "10x raise Oct 22" \ "12 x oct 24, changed k2 = 4 * k3" call /kinetics/chain/kinetics[5]/PLA2/PLA2*-Ca-act/notes LOAD \ "To start off, same kinetics as the PLA2-Ca-act direct pathway." \ "Oops ! Missed out the Ca input to this pathway first time round." \ "Let's raise the forward rate about 3x to 5e-6. This will let us reduce the" \ "rather high rates we have used for the kenz on PLA2*-Ca. In fact, it" \ "may be that the rates are not that different, just that this pathway for" \ "getting the PLA2 to the memb is more efficien...." call /kinetics/chain/kinetics[5]/temp-PIP2/notes LOAD \ "This isn't explicitly present in the M&L model, but is obviously needed." \ "I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim" \ "7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) " \ "Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs," \ "which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984" \ "Lets use a lower level of 30 nM, same ref...." call /kinetics/chain/kinetics[5]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[5]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[5]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[5]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[5]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[5]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[5]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[5]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[5]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[5]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[5]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[5]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[5]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[5]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[5]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[5]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[5]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[5]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[5]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[5]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[5]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[5]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" \ "28 Feb 2006: Increased affinity 36-fold to account for Ca" \ "input to MAPK cascade, possibly folding in other pathway" \ "inputs." \ "21 April 2006: Altered affinity to same level as " \ "pkm_mapk21.g model to prevent spontaneous turnon." \ "Kf = 200, Kb = 1." \ "" \ "" \ "" call /kinetics/chain/kinetics[5]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[5]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras" \ "" call /kinetics/chain/kinetics[5]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[5]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[5]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[5]/PKC-active/phosph-AC2/notes LOAD \ "Phorbol esters have little effect on AC1 or on the Gs-stimulation of" \ "AC2. So in this model we are only dealing with the increase in" \ "basal activation of AC2 induced by PKC" \ "k1 = 1.66e-6" \ "k2 = 16" \ "k3 =4" \ "" call /kinetics/chain/kinetics[5]/MAPK*/MAPK*/notes LOAD \ "Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate)" \ "Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so:" \ "k3 = .5/sec (rate limiting)" \ "k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1" \ "#s from Sanghera et al JBC 265 pp 52 , 1990. " \ "From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio" \ "of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5" call /kinetics/chain/kinetics[5]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[5]/IP3/notes LOAD \ "Peak IP3 is perhaps 15 uM, basal <= 0.2 uM." call /kinetics/chain/kinetics[5]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[5]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[5]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[5]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[5]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[5]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[5]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[5]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[5]/CaM/CaM-TR2-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)...." call /kinetics/chain/kinetics[5]/CaM/CaM-TR2-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[5]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[5]/CaM/CaM-TR2-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[5]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[6]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[6]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[6]/PKC/PKC-act-by-Ca-AA/notes LOAD \ "Schaechter and Benowitz We have to increase Kf for conc scaling" \ "Changed kf to 2e-9 on Sept 19, 94. This gives better match." \ "" call /kinetics/chain/kinetics[6]/PKC/PKC-act-by-DAG-AA/notes LOAD \ "Assume slowish too. Schaechter and Benowitz" call /kinetics/chain/kinetics[6]/PKC/PKC-basal-act/notes LOAD \ "Initial basal levels were set by kf = 1, kb = 20. In model, though, the" \ "basal levels of PKC activity are higher." call /kinetics/chain/kinetics[6]/PKC/PKC-act-by-AA/notes LOAD \ "Raise kf from 1.667e-10 to 2e-10 to get better match to data." call /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[6]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[6]/PKC/PKC-n-DAG-AA/notes LOAD \ "Reduced kf to 0.66X to match Shinomura et al data." \ "Initial: kf = 3.3333e-9" \ "New: 2e-9" \ "Newer: 2e-8" \ "kb was 0.2" \ "now 2." call /kinetics/chain/kinetics[6]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[6]/PLA2/notes LOAD \ "Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270." \ "Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see" \ "Wijkander and Sundler JBC 202 (1991) pp873-880;" \ "Diez and Mong JBC 265(24) p14654;" \ "Leslie JBC 266(17) (1991) pp11366-11371" call /kinetics/chain/kinetics[6]/PLA2/PLA2-cytosolic/notes LOAD \ "Calculated cytosolic was 20 nm from Wijkander and Sundler" \ "However, Leslie and Channon use about 400 nM. Need to confirm," \ "but this is the value I use here. Another recalc of W&S gives 1uM" call /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca-act/notes LOAD \ "Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267." call /kinetics/chain/kinetics[6]/PLA2/PLA2-Ca*/kenz/notes LOAD \ "10 x raise oct22" \ "12 x oct 24, set k2 = 4 * k3" call /kinetics/chain/kinetics[6]/PLA2/PIP2-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X further raise oct 24 to allow for correct conc of enzyme" \ "" call /kinetics/chain/kinetics[6]/PLA2/PIP2-Ca-PLA2*/kenz/notes LOAD \ "10 x raise oct 22" \ "12 x and rescale for k2 = 4 * k3 convention oct 24" \ "Increase further to get the match to expt, which was spoilt due" \ "to large accumulation of PLA2 in the enzyme complexed forms." \ "Lets raise k3, leaving the others at " \ "k1 = 1.5e-5 and k2 = 144 since they are large already." \ "" call /kinetics/chain/kinetics[6]/PLA2/DAG-Ca-PLA2-act/notes LOAD \ "27 June 1996" \ "Scaled kf down by 0.015" \ "from 3.33e-7 to 5e-9" \ "to fit with revised DAG estimates" \ "and use of mole-fraction to calculate eff on PLA2." call /kinetics/chain/kinetics[6]/PLA2/DAG-Ca-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X raise oct 24 + conversion to k2 =4 * k3" call /kinetics/chain/kinetics[6]/PLA2/APC/notes LOAD \ "arachodonylphosphatidylcholine is the favoured substrate" \ "from Wijkander and Sundler, JBC 202 pp 873-880, 1991." \ "Their assay used 30 uM substrate, which is what the kinetics in" \ "this model are based on. For the later model we should locate" \ "a more realistic value for APC." call /kinetics/chain/kinetics[6]/PLA2/Degrade-AA/notes LOAD \ "I need to check if the AA degradation pathway really leads back to " \ "APC. Anyway, it is a convenient buffered pool to dump it back into." \ "For the purposes of the full model we use a rate of degradation of" \ "0.2/sec" \ "Raised decay to 0.4 : see PLA35.g notes for Feb17 " call /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca/notes LOAD \ "Phosphorylated form of PLA2. Still need to hook it up using kinases." \ "PKA: Wightman et al JBC 257 pp6650 1982" \ "PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal" \ "MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone" \ "Do not know if there is a Ca requirement for active phosphorylated state." call /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca/kenz/notes LOAD \ "This form should be 3 to 6 times as fast as the Ca-only form." \ "I have scaled by 4x which seems to give a 5x rise." \ "10x raise Oct 22" \ "12 x oct 24, changed k2 = 4 * k3" call /kinetics/chain/kinetics[6]/PLA2/PLA2*-Ca-act/notes LOAD \ "To start off, same kinetics as the PLA2-Ca-act direct pathway." \ "Oops ! Missed out the Ca input to this pathway first time round." \ "Let's raise the forward rate about 3x to 5e-6. This will let us reduce the" \ "rather high rates we have used for the kenz on PLA2*-Ca. In fact, it" \ "may be that the rates are not that different, just that this pathway for" \ "getting the PLA2 to the memb is more efficien...." call /kinetics/chain/kinetics[6]/temp-PIP2/notes LOAD \ "This isn't explicitly present in the M&L model, but is obviously needed." \ "I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim" \ "7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) " \ "Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs," \ "which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984" \ "Lets use a lower level of 30 nM, same ref...." call /kinetics/chain/kinetics[6]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[6]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[6]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[6]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[6]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[6]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[6]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[6]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[6]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[6]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[6]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[6]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[6]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[6]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[6]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[6]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[6]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[6]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[6]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[6]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[6]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[6]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" \ "28 Feb 2006: Increased affinity 36-fold to account for Ca" \ "input to MAPK cascade, possibly folding in other pathway" \ "inputs." \ "21 April 2006: Altered affinity to same level as " \ "pkm_mapk21.g model to prevent spontaneous turnon." \ "Kf = 200, Kb = 1." \ "" \ "" \ "" call /kinetics/chain/kinetics[6]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[6]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras" \ "" call /kinetics/chain/kinetics[6]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[6]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[6]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[6]/PKC-active/phosph-AC2/notes LOAD \ "Phorbol esters have little effect on AC1 or on the Gs-stimulation of" \ "AC2. So in this model we are only dealing with the increase in" \ "basal activation of AC2 induced by PKC" \ "k1 = 1.66e-6" \ "k2 = 16" \ "k3 =4" \ "" call /kinetics/chain/kinetics[6]/MAPK*/MAPK*/notes LOAD \ "Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate)" \ "Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so:" \ "k3 = .5/sec (rate limiting)" \ "k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1" \ "#s from Sanghera et al JBC 265 pp 52 , 1990. " \ "From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio" \ "of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5" call /kinetics/chain/kinetics[6]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[6]/IP3/notes LOAD \ "Peak IP3 is perhaps 15 uM, basal <= 0.2 uM." call /kinetics/chain/kinetics[6]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[6]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[6]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[6]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[6]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[6]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[6]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[6]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[6]/CaM/CaM-TR2-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)...." call /kinetics/chain/kinetics[6]/CaM/CaM-TR2-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[6]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[6]/CaM/CaM-TR2-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[6]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[7]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[7]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[7]/PKC/PKC-act-by-Ca-AA/notes LOAD \ "Schaechter and Benowitz We have to increase Kf for conc scaling" \ "Changed kf to 2e-9 on Sept 19, 94. This gives better match." \ "" call /kinetics/chain/kinetics[7]/PKC/PKC-act-by-DAG-AA/notes LOAD \ "Assume slowish too. Schaechter and Benowitz" call /kinetics/chain/kinetics[7]/PKC/PKC-basal-act/notes LOAD \ "Initial basal levels were set by kf = 1, kb = 20. In model, though, the" \ "basal levels of PKC activity are higher." call /kinetics/chain/kinetics[7]/PKC/PKC-act-by-AA/notes LOAD \ "Raise kf from 1.667e-10 to 2e-10 to get better match to data." call /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[7]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[7]/PKC/PKC-n-DAG-AA/notes LOAD \ "Reduced kf to 0.66X to match Shinomura et al data." \ "Initial: kf = 3.3333e-9" \ "New: 2e-9" \ "Newer: 2e-8" \ "kb was 0.2" \ "now 2." call /kinetics/chain/kinetics[7]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[7]/PLA2/notes LOAD \ "Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270." \ "Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see" \ "Wijkander and Sundler JBC 202 (1991) pp873-880;" \ "Diez and Mong JBC 265(24) p14654;" \ "Leslie JBC 266(17) (1991) pp11366-11371" call /kinetics/chain/kinetics[7]/PLA2/PLA2-cytosolic/notes LOAD \ "Calculated cytosolic was 20 nm from Wijkander and Sundler" \ "However, Leslie and Channon use about 400 nM. Need to confirm," \ "but this is the value I use here. Another recalc of W&S gives 1uM" call /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca-act/notes LOAD \ "Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267." call /kinetics/chain/kinetics[7]/PLA2/PLA2-Ca*/kenz/notes LOAD \ "10 x raise oct22" \ "12 x oct 24, set k2 = 4 * k3" call /kinetics/chain/kinetics[7]/PLA2/PIP2-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X further raise oct 24 to allow for correct conc of enzyme" \ "" call /kinetics/chain/kinetics[7]/PLA2/PIP2-Ca-PLA2*/kenz/notes LOAD \ "10 x raise oct 22" \ "12 x and rescale for k2 = 4 * k3 convention oct 24" \ "Increase further to get the match to expt, which was spoilt due" \ "to large accumulation of PLA2 in the enzyme complexed forms." \ "Lets raise k3, leaving the others at " \ "k1 = 1.5e-5 and k2 = 144 since they are large already." \ "" call /kinetics/chain/kinetics[7]/PLA2/DAG-Ca-PLA2-act/notes LOAD \ "27 June 1996" \ "Scaled kf down by 0.015" \ "from 3.33e-7 to 5e-9" \ "to fit with revised DAG estimates" \ "and use of mole-fraction to calculate eff on PLA2." call /kinetics/chain/kinetics[7]/PLA2/DAG-Ca-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X raise oct 24 + conversion to k2 =4 * k3" call /kinetics/chain/kinetics[7]/PLA2/APC/notes LOAD \ "arachodonylphosphatidylcholine is the favoured substrate" \ "from Wijkander and Sundler, JBC 202 pp 873-880, 1991." \ "Their assay used 30 uM substrate, which is what the kinetics in" \ "this model are based on. For the later model we should locate" \ "a more realistic value for APC." call /kinetics/chain/kinetics[7]/PLA2/Degrade-AA/notes LOAD \ "I need to check if the AA degradation pathway really leads back to " \ "APC. Anyway, it is a convenient buffered pool to dump it back into." \ "For the purposes of the full model we use a rate of degradation of" \ "0.2/sec" \ "Raised decay to 0.4 : see PLA35.g notes for Feb17 " call /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca/notes LOAD \ "Phosphorylated form of PLA2. Still need to hook it up using kinases." \ "PKA: Wightman et al JBC 257 pp6650 1982" \ "PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal" \ "MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone" \ "Do not know if there is a Ca requirement for active phosphorylated state." call /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca/kenz/notes LOAD \ "This form should be 3 to 6 times as fast as the Ca-only form." \ "I have scaled by 4x which seems to give a 5x rise." \ "10x raise Oct 22" \ "12 x oct 24, changed k2 = 4 * k3" call /kinetics/chain/kinetics[7]/PLA2/PLA2*-Ca-act/notes LOAD \ "To start off, same kinetics as the PLA2-Ca-act direct pathway." \ "Oops ! Missed out the Ca input to this pathway first time round." \ "Let's raise the forward rate about 3x to 5e-6. This will let us reduce the" \ "rather high rates we have used for the kenz on PLA2*-Ca. In fact, it" \ "may be that the rates are not that different, just that this pathway for" \ "getting the PLA2 to the memb is more efficien...." call /kinetics/chain/kinetics[7]/temp-PIP2/notes LOAD \ "This isn't explicitly present in the M&L model, but is obviously needed." \ "I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim" \ "7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) " \ "Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs," \ "which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984" \ "Lets use a lower level of 30 nM, same ref...." call /kinetics/chain/kinetics[7]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[7]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[7]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[7]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[7]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[7]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[7]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[7]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[7]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[7]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[7]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[7]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[7]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[7]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[7]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[7]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[7]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[7]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[7]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[7]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[7]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[7]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" \ "28 Feb 2006: Increased affinity 36-fold to account for Ca" \ "input to MAPK cascade, possibly folding in other pathway" \ "inputs." \ "21 April 2006: Altered affinity to same level as " \ "pkm_mapk21.g model to prevent spontaneous turnon." \ "Kf = 200, Kb = 1." \ "" \ "" \ "" call /kinetics/chain/kinetics[7]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[7]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras" \ "" call /kinetics/chain/kinetics[7]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[7]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[7]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[7]/PKC-active/phosph-AC2/notes LOAD \ "Phorbol esters have little effect on AC1 or on the Gs-stimulation of" \ "AC2. So in this model we are only dealing with the increase in" \ "basal activation of AC2 induced by PKC" \ "k1 = 1.66e-6" \ "k2 = 16" \ "k3 =4" \ "" call /kinetics/chain/kinetics[7]/MAPK*/MAPK*/notes LOAD \ "Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate)" \ "Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so:" \ "k3 = .5/sec (rate limiting)" \ "k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1" \ "#s from Sanghera et al JBC 265 pp 52 , 1990. " \ "From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio" \ "of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5" call /kinetics/chain/kinetics[7]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[7]/IP3/notes LOAD \ "Peak IP3 is perhaps 15 uM, basal <= 0.2 uM." call /kinetics/chain/kinetics[7]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[7]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[7]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[7]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[7]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[7]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[7]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[7]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[7]/CaM/CaM-TR2-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)...." call /kinetics/chain/kinetics[7]/CaM/CaM-TR2-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[7]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[7]/CaM/CaM-TR2-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[7]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[8]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[8]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[8]/PKC/PKC-act-by-Ca-AA/notes LOAD \ "Schaechter and Benowitz We have to increase Kf for conc scaling" \ "Changed kf to 2e-9 on Sept 19, 94. This gives better match." \ "" call /kinetics/chain/kinetics[8]/PKC/PKC-act-by-DAG-AA/notes LOAD \ "Assume slowish too. Schaechter and Benowitz" call /kinetics/chain/kinetics[8]/PKC/PKC-basal-act/notes LOAD \ "Initial basal levels were set by kf = 1, kb = 20. In model, though, the" \ "basal levels of PKC activity are higher." call /kinetics/chain/kinetics[8]/PKC/PKC-act-by-AA/notes LOAD \ "Raise kf from 1.667e-10 to 2e-10 to get better match to data." call /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[8]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[8]/PKC/PKC-n-DAG-AA/notes LOAD \ "Reduced kf to 0.66X to match Shinomura et al data." \ "Initial: kf = 3.3333e-9" \ "New: 2e-9" \ "Newer: 2e-8" \ "kb was 0.2" \ "now 2." call /kinetics/chain/kinetics[8]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[8]/PLA2/notes LOAD \ "Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270." \ "Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see" \ "Wijkander and Sundler JBC 202 (1991) pp873-880;" \ "Diez and Mong JBC 265(24) p14654;" \ "Leslie JBC 266(17) (1991) pp11366-11371" call /kinetics/chain/kinetics[8]/PLA2/PLA2-cytosolic/notes LOAD \ "Calculated cytosolic was 20 nm from Wijkander and Sundler" \ "However, Leslie and Channon use about 400 nM. Need to confirm," \ "but this is the value I use here. Another recalc of W&S gives 1uM" call /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca-act/notes LOAD \ "Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267." call /kinetics/chain/kinetics[8]/PLA2/PLA2-Ca*/kenz/notes LOAD \ "10 x raise oct22" \ "12 x oct 24, set k2 = 4 * k3" call /kinetics/chain/kinetics[8]/PLA2/PIP2-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X further raise oct 24 to allow for correct conc of enzyme" \ "" call /kinetics/chain/kinetics[8]/PLA2/PIP2-Ca-PLA2*/kenz/notes LOAD \ "10 x raise oct 22" \ "12 x and rescale for k2 = 4 * k3 convention oct 24" \ "Increase further to get the match to expt, which was spoilt due" \ "to large accumulation of PLA2 in the enzyme complexed forms." \ "Lets raise k3, leaving the others at " \ "k1 = 1.5e-5 and k2 = 144 since they are large already." \ "" call /kinetics/chain/kinetics[8]/PLA2/DAG-Ca-PLA2-act/notes LOAD \ "27 June 1996" \ "Scaled kf down by 0.015" \ "from 3.33e-7 to 5e-9" \ "to fit with revised DAG estimates" \ "and use of mole-fraction to calculate eff on PLA2." call /kinetics/chain/kinetics[8]/PLA2/DAG-Ca-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X raise oct 24 + conversion to k2 =4 * k3" call /kinetics/chain/kinetics[8]/PLA2/APC/notes LOAD \ "arachodonylphosphatidylcholine is the favoured substrate" \ "from Wijkander and Sundler, JBC 202 pp 873-880, 1991." \ "Their assay used 30 uM substrate, which is what the kinetics in" \ "this model are based on. For the later model we should locate" \ "a more realistic value for APC." call /kinetics/chain/kinetics[8]/PLA2/Degrade-AA/notes LOAD \ "I need to check if the AA degradation pathway really leads back to " \ "APC. Anyway, it is a convenient buffered pool to dump it back into." \ "For the purposes of the full model we use a rate of degradation of" \ "0.2/sec" \ "Raised decay to 0.4 : see PLA35.g notes for Feb17 " call /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca/notes LOAD \ "Phosphorylated form of PLA2. Still need to hook it up using kinases." \ "PKA: Wightman et al JBC 257 pp6650 1982" \ "PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal" \ "MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone" \ "Do not know if there is a Ca requirement for active phosphorylated state." call /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca/kenz/notes LOAD \ "This form should be 3 to 6 times as fast as the Ca-only form." \ "I have scaled by 4x which seems to give a 5x rise." \ "10x raise Oct 22" \ "12 x oct 24, changed k2 = 4 * k3" call /kinetics/chain/kinetics[8]/PLA2/PLA2*-Ca-act/notes LOAD \ "To start off, same kinetics as the PLA2-Ca-act direct pathway." \ "Oops ! Missed out the Ca input to this pathway first time round." \ "Let's raise the forward rate about 3x to 5e-6. This will let us reduce the" \ "rather high rates we have used for the kenz on PLA2*-Ca. In fact, it" \ "may be that the rates are not that different, just that this pathway for" \ "getting the PLA2 to the memb is more efficien...." call /kinetics/chain/kinetics[8]/temp-PIP2/notes LOAD \ "This isn't explicitly present in the M&L model, but is obviously needed." \ "I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim" \ "7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) " \ "Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs," \ "which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984" \ "Lets use a lower level of 30 nM, same ref...." call /kinetics/chain/kinetics[8]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[8]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[8]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[8]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[8]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[8]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[8]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[8]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[8]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[8]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[8]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[8]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[8]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[8]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[8]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[8]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[8]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[8]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[8]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[8]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[8]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[8]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" \ "28 Feb 2006: Increased affinity 36-fold to account for Ca" \ "input to MAPK cascade, possibly folding in other pathway" \ "inputs." \ "21 April 2006: Altered affinity to same level as " \ "pkm_mapk21.g model to prevent spontaneous turnon." \ "Kf = 200, Kb = 1." \ "" \ "" \ "" call /kinetics/chain/kinetics[8]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[8]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras" \ "" call /kinetics/chain/kinetics[8]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[8]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[8]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[8]/PKC-active/phosph-AC2/notes LOAD \ "Phorbol esters have little effect on AC1 or on the Gs-stimulation of" \ "AC2. So in this model we are only dealing with the increase in" \ "basal activation of AC2 induced by PKC" \ "k1 = 1.66e-6" \ "k2 = 16" \ "k3 =4" \ "" call /kinetics/chain/kinetics[8]/MAPK*/MAPK*/notes LOAD \ "Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate)" \ "Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so:" \ "k3 = .5/sec (rate limiting)" \ "k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1" \ "#s from Sanghera et al JBC 265 pp 52 , 1990. " \ "From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio" \ "of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5" call /kinetics/chain/kinetics[8]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[8]/IP3/notes LOAD \ "Peak IP3 is perhaps 15 uM, basal <= 0.2 uM." call /kinetics/chain/kinetics[8]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[8]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[8]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[8]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[8]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[8]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[8]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[8]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[8]/CaM/CaM-TR2-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)...." call /kinetics/chain/kinetics[8]/CaM/CaM-TR2-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[8]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[8]/CaM/CaM-TR2-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[8]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[9]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[9]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[9]/PKC/PKC-act-by-Ca-AA/notes LOAD \ "Schaechter and Benowitz We have to increase Kf for conc scaling" \ "Changed kf to 2e-9 on Sept 19, 94. This gives better match." \ "" call /kinetics/chain/kinetics[9]/PKC/PKC-act-by-DAG-AA/notes LOAD \ "Assume slowish too. Schaechter and Benowitz" call /kinetics/chain/kinetics[9]/PKC/PKC-basal-act/notes LOAD \ "Initial basal levels were set by kf = 1, kb = 20. In model, though, the" \ "basal levels of PKC activity are higher." call /kinetics/chain/kinetics[9]/PKC/PKC-act-by-AA/notes LOAD \ "Raise kf from 1.667e-10 to 2e-10 to get better match to data." call /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[9]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[9]/PKC/PKC-n-DAG-AA/notes LOAD \ "Reduced kf to 0.66X to match Shinomura et al data." \ "Initial: kf = 3.3333e-9" \ "New: 2e-9" \ "Newer: 2e-8" \ "kb was 0.2" \ "now 2." call /kinetics/chain/kinetics[9]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[9]/PLA2/notes LOAD \ "Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270." \ "Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see" \ "Wijkander and Sundler JBC 202 (1991) pp873-880;" \ "Diez and Mong JBC 265(24) p14654;" \ "Leslie JBC 266(17) (1991) pp11366-11371" call /kinetics/chain/kinetics[9]/PLA2/PLA2-cytosolic/notes LOAD \ "Calculated cytosolic was 20 nm from Wijkander and Sundler" \ "However, Leslie and Channon use about 400 nM. Need to confirm," \ "but this is the value I use here. Another recalc of W&S gives 1uM" call /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca-act/notes LOAD \ "Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267." call /kinetics/chain/kinetics[9]/PLA2/PLA2-Ca*/kenz/notes LOAD \ "10 x raise oct22" \ "12 x oct 24, set k2 = 4 * k3" call /kinetics/chain/kinetics[9]/PLA2/PIP2-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X further raise oct 24 to allow for correct conc of enzyme" \ "" call /kinetics/chain/kinetics[9]/PLA2/PIP2-Ca-PLA2*/kenz/notes LOAD \ "10 x raise oct 22" \ "12 x and rescale for k2 = 4 * k3 convention oct 24" \ "Increase further to get the match to expt, which was spoilt due" \ "to large accumulation of PLA2 in the enzyme complexed forms." \ "Lets raise k3, leaving the others at " \ "k1 = 1.5e-5 and k2 = 144 since they are large already." \ "" call /kinetics/chain/kinetics[9]/PLA2/DAG-Ca-PLA2-act/notes LOAD \ "27 June 1996" \ "Scaled kf down by 0.015" \ "from 3.33e-7 to 5e-9" \ "to fit with revised DAG estimates" \ "and use of mole-fraction to calculate eff on PLA2." call /kinetics/chain/kinetics[9]/PLA2/DAG-Ca-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X raise oct 24 + conversion to k2 =4 * k3" call /kinetics/chain/kinetics[9]/PLA2/APC/notes LOAD \ "arachodonylphosphatidylcholine is the favoured substrate" \ "from Wijkander and Sundler, JBC 202 pp 873-880, 1991." \ "Their assay used 30 uM substrate, which is what the kinetics in" \ "this model are based on. For the later model we should locate" \ "a more realistic value for APC." call /kinetics/chain/kinetics[9]/PLA2/Degrade-AA/notes LOAD \ "I need to check if the AA degradation pathway really leads back to " \ "APC. Anyway, it is a convenient buffered pool to dump it back into." \ "For the purposes of the full model we use a rate of degradation of" \ "0.2/sec" \ "Raised decay to 0.4 : see PLA35.g notes for Feb17 " call /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca/notes LOAD \ "Phosphorylated form of PLA2. Still need to hook it up using kinases." \ "PKA: Wightman et al JBC 257 pp6650 1982" \ "PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal" \ "MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone" \ "Do not know if there is a Ca requirement for active phosphorylated state." call /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca/kenz/notes LOAD \ "This form should be 3 to 6 times as fast as the Ca-only form." \ "I have scaled by 4x which seems to give a 5x rise." \ "10x raise Oct 22" \ "12 x oct 24, changed k2 = 4 * k3" call /kinetics/chain/kinetics[9]/PLA2/PLA2*-Ca-act/notes LOAD \ "To start off, same kinetics as the PLA2-Ca-act direct pathway." \ "Oops ! Missed out the Ca input to this pathway first time round." \ "Let's raise the forward rate about 3x to 5e-6. This will let us reduce the" \ "rather high rates we have used for the kenz on PLA2*-Ca. In fact, it" \ "may be that the rates are not that different, just that this pathway for" \ "getting the PLA2 to the memb is more efficien...." call /kinetics/chain/kinetics[9]/temp-PIP2/notes LOAD \ "This isn't explicitly present in the M&L model, but is obviously needed." \ "I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim" \ "7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) " \ "Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs," \ "which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984" \ "Lets use a lower level of 30 nM, same ref...." call /kinetics/chain/kinetics[9]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[9]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[9]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[9]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[9]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[9]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[9]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[9]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[9]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[9]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[9]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[9]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[9]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[9]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[9]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[9]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[9]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[9]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[9]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[9]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[9]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[9]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" \ "28 Feb 2006: Increased affinity 36-fold to account for Ca" \ "input to MAPK cascade, possibly folding in other pathway" \ "inputs." \ "21 April 2006: Altered affinity to same level as " \ "pkm_mapk21.g model to prevent spontaneous turnon." \ "Kf = 200, Kb = 1." \ "" \ "" \ "" call /kinetics/chain/kinetics[9]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[9]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras" \ "" call /kinetics/chain/kinetics[9]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[9]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[9]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[9]/PKC-active/phosph-AC2/notes LOAD \ "Phorbol esters have little effect on AC1 or on the Gs-stimulation of" \ "AC2. So in this model we are only dealing with the increase in" \ "basal activation of AC2 induced by PKC" \ "k1 = 1.66e-6" \ "k2 = 16" \ "k3 =4" \ "" call /kinetics/chain/kinetics[9]/MAPK*/MAPK*/notes LOAD \ "Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate)" \ "Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so:" \ "k3 = .5/sec (rate limiting)" \ "k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1" \ "#s from Sanghera et al JBC 265 pp 52 , 1990. " \ "From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio" \ "of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5" call /kinetics/chain/kinetics[9]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[9]/IP3/notes LOAD \ "Peak IP3 is perhaps 15 uM, basal <= 0.2 uM." call /kinetics/chain/kinetics[9]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[9]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[9]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[9]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[9]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[9]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[9]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[9]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[9]/CaM/CaM-TR2-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)...." call /kinetics/chain/kinetics[9]/CaM/CaM-TR2-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[9]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[9]/CaM/CaM-TR2-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[9]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[10]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[10]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[10]/PKC/PKC-act-by-Ca-AA/notes LOAD \ "Schaechter and Benowitz We have to increase Kf for conc scaling" \ "Changed kf to 2e-9 on Sept 19, 94. This gives better match." \ "" call /kinetics/chain/kinetics[10]/PKC/PKC-act-by-DAG-AA/notes LOAD \ "Assume slowish too. Schaechter and Benowitz" call /kinetics/chain/kinetics[10]/PKC/PKC-basal-act/notes LOAD \ "Initial basal levels were set by kf = 1, kb = 20. In model, though, the" \ "basal levels of PKC activity are higher." call /kinetics/chain/kinetics[10]/PKC/PKC-act-by-AA/notes LOAD \ "Raise kf from 1.667e-10 to 2e-10 to get better match to data." call /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[10]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[10]/PKC/PKC-n-DAG-AA/notes LOAD \ "Reduced kf to 0.66X to match Shinomura et al data." \ "Initial: kf = 3.3333e-9" \ "New: 2e-9" \ "Newer: 2e-8" \ "kb was 0.2" \ "now 2." call /kinetics/chain/kinetics[10]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[10]/PLA2/notes LOAD \ "Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270." \ "Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see" \ "Wijkander and Sundler JBC 202 (1991) pp873-880;" \ "Diez and Mong JBC 265(24) p14654;" \ "Leslie JBC 266(17) (1991) pp11366-11371" call /kinetics/chain/kinetics[10]/PLA2/PLA2-cytosolic/notes LOAD \ "Calculated cytosolic was 20 nm from Wijkander and Sundler" \ "However, Leslie and Channon use about 400 nM. Need to confirm," \ "but this is the value I use here. Another recalc of W&S gives 1uM" call /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca-act/notes LOAD \ "Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267." call /kinetics/chain/kinetics[10]/PLA2/PLA2-Ca*/kenz/notes LOAD \ "10 x raise oct22" \ "12 x oct 24, set k2 = 4 * k3" call /kinetics/chain/kinetics[10]/PLA2/PIP2-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X further raise oct 24 to allow for correct conc of enzyme" \ "" call /kinetics/chain/kinetics[10]/PLA2/PIP2-Ca-PLA2*/kenz/notes LOAD \ "10 x raise oct 22" \ "12 x and rescale for k2 = 4 * k3 convention oct 24" \ "Increase further to get the match to expt, which was spoilt due" \ "to large accumulation of PLA2 in the enzyme complexed forms." \ "Lets raise k3, leaving the others at " \ "k1 = 1.5e-5 and k2 = 144 since they are large already." \ "" call /kinetics/chain/kinetics[10]/PLA2/DAG-Ca-PLA2-act/notes LOAD \ "27 June 1996" \ "Scaled kf down by 0.015" \ "from 3.33e-7 to 5e-9" \ "to fit with revised DAG estimates" \ "and use of mole-fraction to calculate eff on PLA2." call /kinetics/chain/kinetics[10]/PLA2/DAG-Ca-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X raise oct 24 + conversion to k2 =4 * k3" call /kinetics/chain/kinetics[10]/PLA2/APC/notes LOAD \ "arachodonylphosphatidylcholine is the favoured substrate" \ "from Wijkander and Sundler, JBC 202 pp 873-880, 1991." \ "Their assay used 30 uM substrate, which is what the kinetics in" \ "this model are based on. For the later model we should locate" \ "a more realistic value for APC." call /kinetics/chain/kinetics[10]/PLA2/Degrade-AA/notes LOAD \ "I need to check if the AA degradation pathway really leads back to " \ "APC. Anyway, it is a convenient buffered pool to dump it back into." \ "For the purposes of the full model we use a rate of degradation of" \ "0.2/sec" \ "Raised decay to 0.4 : see PLA35.g notes for Feb17 " call /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca/notes LOAD \ "Phosphorylated form of PLA2. Still need to hook it up using kinases." \ "PKA: Wightman et al JBC 257 pp6650 1982" \ "PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal" \ "MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone" \ "Do not know if there is a Ca requirement for active phosphorylated state." call /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca/kenz/notes LOAD \ "This form should be 3 to 6 times as fast as the Ca-only form." \ "I have scaled by 4x which seems to give a 5x rise." \ "10x raise Oct 22" \ "12 x oct 24, changed k2 = 4 * k3" call /kinetics/chain/kinetics[10]/PLA2/PLA2*-Ca-act/notes LOAD \ "To start off, same kinetics as the PLA2-Ca-act direct pathway." \ "Oops ! Missed out the Ca input to this pathway first time round." \ "Let's raise the forward rate about 3x to 5e-6. This will let us reduce the" \ "rather high rates we have used for the kenz on PLA2*-Ca. In fact, it" \ "may be that the rates are not that different, just that this pathway for" \ "getting the PLA2 to the memb is more efficien...." call /kinetics/chain/kinetics[10]/temp-PIP2/notes LOAD \ "This isn't explicitly present in the M&L model, but is obviously needed." \ "I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim" \ "7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) " \ "Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs," \ "which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984" \ "Lets use a lower level of 30 nM, same ref...." call /kinetics/chain/kinetics[10]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[10]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[10]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[10]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[10]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[10]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[10]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[10]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[10]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[10]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[10]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[10]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[10]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[10]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[10]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[10]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[10]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[10]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[10]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[10]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[10]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[10]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" \ "28 Feb 2006: Increased affinity 36-fold to account for Ca" \ "input to MAPK cascade, possibly folding in other pathway" \ "inputs." \ "21 April 2006: Altered affinity to same level as " \ "pkm_mapk21.g model to prevent spontaneous turnon." \ "Kf = 200, Kb = 1." \ "" \ "" \ "" call /kinetics/chain/kinetics[10]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[10]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras" \ "" call /kinetics/chain/kinetics[10]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[10]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[10]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[10]/PKC-active/phosph-AC2/notes LOAD \ "Phorbol esters have little effect on AC1 or on the Gs-stimulation of" \ "AC2. So in this model we are only dealing with the increase in" \ "basal activation of AC2 induced by PKC" \ "k1 = 1.66e-6" \ "k2 = 16" \ "k3 =4" \ "" call /kinetics/chain/kinetics[10]/MAPK*/MAPK*/notes LOAD \ "Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate)" \ "Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so:" \ "k3 = .5/sec (rate limiting)" \ "k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1" \ "#s from Sanghera et al JBC 265 pp 52 , 1990. " \ "From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio" \ "of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5" call /kinetics/chain/kinetics[10]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[10]/IP3/notes LOAD \ "Peak IP3 is perhaps 15 uM, basal <= 0.2 uM." call /kinetics/chain/kinetics[10]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[10]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[10]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[10]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[10]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[10]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[10]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[10]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[10]/CaM/CaM-TR2-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)...." call /kinetics/chain/kinetics[10]/CaM/CaM-TR2-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[10]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[10]/CaM/CaM-TR2-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[10]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[11]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[11]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[11]/PKC/PKC-act-by-Ca-AA/notes LOAD \ "Schaechter and Benowitz We have to increase Kf for conc scaling" \ "Changed kf to 2e-9 on Sept 19, 94. This gives better match." \ "" call /kinetics/chain/kinetics[11]/PKC/PKC-act-by-DAG-AA/notes LOAD \ "Assume slowish too. Schaechter and Benowitz" call /kinetics/chain/kinetics[11]/PKC/PKC-basal-act/notes LOAD \ "Initial basal levels were set by kf = 1, kb = 20. In model, though, the" \ "basal levels of PKC activity are higher." call /kinetics/chain/kinetics[11]/PKC/PKC-act-by-AA/notes LOAD \ "Raise kf from 1.667e-10 to 2e-10 to get better match to data." call /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[11]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[11]/PKC/PKC-n-DAG-AA/notes LOAD \ "Reduced kf to 0.66X to match Shinomura et al data." \ "Initial: kf = 3.3333e-9" \ "New: 2e-9" \ "Newer: 2e-8" \ "kb was 0.2" \ "now 2." call /kinetics/chain/kinetics[11]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[11]/PLA2/notes LOAD \ "Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270." \ "Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see" \ "Wijkander and Sundler JBC 202 (1991) pp873-880;" \ "Diez and Mong JBC 265(24) p14654;" \ "Leslie JBC 266(17) (1991) pp11366-11371" call /kinetics/chain/kinetics[11]/PLA2/PLA2-cytosolic/notes LOAD \ "Calculated cytosolic was 20 nm from Wijkander and Sundler" \ "However, Leslie and Channon use about 400 nM. Need to confirm," \ "but this is the value I use here. Another recalc of W&S gives 1uM" call /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca-act/notes LOAD \ "Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267." call /kinetics/chain/kinetics[11]/PLA2/PLA2-Ca*/kenz/notes LOAD \ "10 x raise oct22" \ "12 x oct 24, set k2 = 4 * k3" call /kinetics/chain/kinetics[11]/PLA2/PIP2-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X further raise oct 24 to allow for correct conc of enzyme" \ "" call /kinetics/chain/kinetics[11]/PLA2/PIP2-Ca-PLA2*/kenz/notes LOAD \ "10 x raise oct 22" \ "12 x and rescale for k2 = 4 * k3 convention oct 24" \ "Increase further to get the match to expt, which was spoilt due" \ "to large accumulation of PLA2 in the enzyme complexed forms." \ "Lets raise k3, leaving the others at " \ "k1 = 1.5e-5 and k2 = 144 since they are large already." \ "" call /kinetics/chain/kinetics[11]/PLA2/DAG-Ca-PLA2-act/notes LOAD \ "27 June 1996" \ "Scaled kf down by 0.015" \ "from 3.33e-7 to 5e-9" \ "to fit with revised DAG estimates" \ "and use of mole-fraction to calculate eff on PLA2." call /kinetics/chain/kinetics[11]/PLA2/DAG-Ca-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X raise oct 24 + conversion to k2 =4 * k3" call /kinetics/chain/kinetics[11]/PLA2/APC/notes LOAD \ "arachodonylphosphatidylcholine is the favoured substrate" \ "from Wijkander and Sundler, JBC 202 pp 873-880, 1991." \ "Their assay used 30 uM substrate, which is what the kinetics in" \ "this model are based on. For the later model we should locate" \ "a more realistic value for APC." call /kinetics/chain/kinetics[11]/PLA2/Degrade-AA/notes LOAD \ "I need to check if the AA degradation pathway really leads back to " \ "APC. Anyway, it is a convenient buffered pool to dump it back into." \ "For the purposes of the full model we use a rate of degradation of" \ "0.2/sec" \ "Raised decay to 0.4 : see PLA35.g notes for Feb17 " call /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca/notes LOAD \ "Phosphorylated form of PLA2. Still need to hook it up using kinases." \ "PKA: Wightman et al JBC 257 pp6650 1982" \ "PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal" \ "MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone" \ "Do not know if there is a Ca requirement for active phosphorylated state." call /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca/kenz/notes LOAD \ "This form should be 3 to 6 times as fast as the Ca-only form." \ "I have scaled by 4x which seems to give a 5x rise." \ "10x raise Oct 22" \ "12 x oct 24, changed k2 = 4 * k3" call /kinetics/chain/kinetics[11]/PLA2/PLA2*-Ca-act/notes LOAD \ "To start off, same kinetics as the PLA2-Ca-act direct pathway." \ "Oops ! Missed out the Ca input to this pathway first time round." \ "Let's raise the forward rate about 3x to 5e-6. This will let us reduce the" \ "rather high rates we have used for the kenz on PLA2*-Ca. In fact, it" \ "may be that the rates are not that different, just that this pathway for" \ "getting the PLA2 to the memb is more efficien...." call /kinetics/chain/kinetics[11]/temp-PIP2/notes LOAD \ "This isn't explicitly present in the M&L model, but is obviously needed." \ "I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim" \ "7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) " \ "Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs," \ "which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984" \ "Lets use a lower level of 30 nM, same ref...." call /kinetics/chain/kinetics[11]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[11]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[11]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[11]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[11]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[11]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[11]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[11]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[11]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[11]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[11]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[11]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[11]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[11]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[11]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[11]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[11]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[11]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[11]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[11]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[11]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[11]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" \ "28 Feb 2006: Increased affinity 36-fold to account for Ca" \ "input to MAPK cascade, possibly folding in other pathway" \ "inputs." \ "21 April 2006: Altered affinity to same level as " \ "pkm_mapk21.g model to prevent spontaneous turnon." \ "Kf = 200, Kb = 1." \ "" \ "" \ "" call /kinetics/chain/kinetics[11]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[11]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras" \ "" call /kinetics/chain/kinetics[11]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[11]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[11]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[11]/PKC-active/phosph-AC2/notes LOAD \ "Phorbol esters have little effect on AC1 or on the Gs-stimulation of" \ "AC2. So in this model we are only dealing with the increase in" \ "basal activation of AC2 induced by PKC" \ "k1 = 1.66e-6" \ "k2 = 16" \ "k3 =4" \ "" call /kinetics/chain/kinetics[11]/MAPK*/MAPK*/notes LOAD \ "Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate)" \ "Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so:" \ "k3 = .5/sec (rate limiting)" \ "k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1" \ "#s from Sanghera et al JBC 265 pp 52 , 1990. " \ "From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio" \ "of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5" call /kinetics/chain/kinetics[11]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[11]/IP3/notes LOAD \ "Peak IP3 is perhaps 15 uM, basal <= 0.2 uM." call /kinetics/chain/kinetics[11]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[11]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[11]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[11]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[11]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[11]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[11]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[11]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[11]/CaM/CaM-TR2-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)...." call /kinetics/chain/kinetics[11]/CaM/CaM-TR2-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[11]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[11]/CaM/CaM-TR2-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[11]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[12]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[12]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[12]/PKC/PKC-act-by-Ca-AA/notes LOAD \ "Schaechter and Benowitz We have to increase Kf for conc scaling" \ "Changed kf to 2e-9 on Sept 19, 94. This gives better match." \ "" call /kinetics/chain/kinetics[12]/PKC/PKC-act-by-DAG-AA/notes LOAD \ "Assume slowish too. Schaechter and Benowitz" call /kinetics/chain/kinetics[12]/PKC/PKC-basal-act/notes LOAD \ "Initial basal levels were set by kf = 1, kb = 20. In model, though, the" \ "basal levels of PKC activity are higher." call /kinetics/chain/kinetics[12]/PKC/PKC-act-by-AA/notes LOAD \ "Raise kf from 1.667e-10 to 2e-10 to get better match to data." call /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[12]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[12]/PKC/PKC-n-DAG-AA/notes LOAD \ "Reduced kf to 0.66X to match Shinomura et al data." \ "Initial: kf = 3.3333e-9" \ "New: 2e-9" \ "Newer: 2e-8" \ "kb was 0.2" \ "now 2." call /kinetics/chain/kinetics[12]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[12]/PLA2/notes LOAD \ "Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270." \ "Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see" \ "Wijkander and Sundler JBC 202 (1991) pp873-880;" \ "Diez and Mong JBC 265(24) p14654;" \ "Leslie JBC 266(17) (1991) pp11366-11371" call /kinetics/chain/kinetics[12]/PLA2/PLA2-cytosolic/notes LOAD \ "Calculated cytosolic was 20 nm from Wijkander and Sundler" \ "However, Leslie and Channon use about 400 nM. Need to confirm," \ "but this is the value I use here. Another recalc of W&S gives 1uM" call /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca-act/notes LOAD \ "Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267." call /kinetics/chain/kinetics[12]/PLA2/PLA2-Ca*/kenz/notes LOAD \ "10 x raise oct22" \ "12 x oct 24, set k2 = 4 * k3" call /kinetics/chain/kinetics[12]/PLA2/PIP2-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X further raise oct 24 to allow for correct conc of enzyme" \ "" call /kinetics/chain/kinetics[12]/PLA2/PIP2-Ca-PLA2*/kenz/notes LOAD \ "10 x raise oct 22" \ "12 x and rescale for k2 = 4 * k3 convention oct 24" \ "Increase further to get the match to expt, which was spoilt due" \ "to large accumulation of PLA2 in the enzyme complexed forms." \ "Lets raise k3, leaving the others at " \ "k1 = 1.5e-5 and k2 = 144 since they are large already." \ "" call /kinetics/chain/kinetics[12]/PLA2/DAG-Ca-PLA2-act/notes LOAD \ "27 June 1996" \ "Scaled kf down by 0.015" \ "from 3.33e-7 to 5e-9" \ "to fit with revised DAG estimates" \ "and use of mole-fraction to calculate eff on PLA2." call /kinetics/chain/kinetics[12]/PLA2/DAG-Ca-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X raise oct 24 + conversion to k2 =4 * k3" call /kinetics/chain/kinetics[12]/PLA2/APC/notes LOAD \ "arachodonylphosphatidylcholine is the favoured substrate" \ "from Wijkander and Sundler, JBC 202 pp 873-880, 1991." \ "Their assay used 30 uM substrate, which is what the kinetics in" \ "this model are based on. For the later model we should locate" \ "a more realistic value for APC." call /kinetics/chain/kinetics[12]/PLA2/Degrade-AA/notes LOAD \ "I need to check if the AA degradation pathway really leads back to " \ "APC. Anyway, it is a convenient buffered pool to dump it back into." \ "For the purposes of the full model we use a rate of degradation of" \ "0.2/sec" \ "Raised decay to 0.4 : see PLA35.g notes for Feb17 " call /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca/notes LOAD \ "Phosphorylated form of PLA2. Still need to hook it up using kinases." \ "PKA: Wightman et al JBC 257 pp6650 1982" \ "PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal" \ "MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone" \ "Do not know if there is a Ca requirement for active phosphorylated state." call /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca/kenz/notes LOAD \ "This form should be 3 to 6 times as fast as the Ca-only form." \ "I have scaled by 4x which seems to give a 5x rise." \ "10x raise Oct 22" \ "12 x oct 24, changed k2 = 4 * k3" call /kinetics/chain/kinetics[12]/PLA2/PLA2*-Ca-act/notes LOAD \ "To start off, same kinetics as the PLA2-Ca-act direct pathway." \ "Oops ! Missed out the Ca input to this pathway first time round." \ "Let's raise the forward rate about 3x to 5e-6. This will let us reduce the" \ "rather high rates we have used for the kenz on PLA2*-Ca. In fact, it" \ "may be that the rates are not that different, just that this pathway for" \ "getting the PLA2 to the memb is more efficien...." call /kinetics/chain/kinetics[12]/temp-PIP2/notes LOAD \ "This isn't explicitly present in the M&L model, but is obviously needed." \ "I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim" \ "7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) " \ "Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs," \ "which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984" \ "Lets use a lower level of 30 nM, same ref...." call /kinetics/chain/kinetics[12]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[12]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[12]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[12]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[12]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[12]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[12]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[12]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[12]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[12]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[12]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[12]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[12]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[12]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[12]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[12]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[12]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[12]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[12]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[12]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[12]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[12]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" \ "28 Feb 2006: Increased affinity 36-fold to account for Ca" \ "input to MAPK cascade, possibly folding in other pathway" \ "inputs." \ "21 April 2006: Altered affinity to same level as " \ "pkm_mapk21.g model to prevent spontaneous turnon." \ "Kf = 200, Kb = 1." \ "" \ "" \ "" call /kinetics/chain/kinetics[12]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[12]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras" \ "" call /kinetics/chain/kinetics[12]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[12]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[12]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[12]/PKC-active/phosph-AC2/notes LOAD \ "Phorbol esters have little effect on AC1 or on the Gs-stimulation of" \ "AC2. So in this model we are only dealing with the increase in" \ "basal activation of AC2 induced by PKC" \ "k1 = 1.66e-6" \ "k2 = 16" \ "k3 =4" \ "" call /kinetics/chain/kinetics[12]/MAPK*/MAPK*/notes LOAD \ "Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate)" \ "Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so:" \ "k3 = .5/sec (rate limiting)" \ "k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1" \ "#s from Sanghera et al JBC 265 pp 52 , 1990. " \ "From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio" \ "of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5" call /kinetics/chain/kinetics[12]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[12]/IP3/notes LOAD \ "Peak IP3 is perhaps 15 uM, basal <= 0.2 uM." call /kinetics/chain/kinetics[12]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[12]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[12]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[12]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[12]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[12]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[12]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[12]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[12]/CaM/CaM-TR2-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)...." call /kinetics/chain/kinetics[12]/CaM/CaM-TR2-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[12]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[12]/CaM/CaM-TR2-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[12]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[13]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[13]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[13]/PKC/PKC-act-by-Ca-AA/notes LOAD \ "Schaechter and Benowitz We have to increase Kf for conc scaling" \ "Changed kf to 2e-9 on Sept 19, 94. This gives better match." \ "" call /kinetics/chain/kinetics[13]/PKC/PKC-act-by-DAG-AA/notes LOAD \ "Assume slowish too. Schaechter and Benowitz" call /kinetics/chain/kinetics[13]/PKC/PKC-basal-act/notes LOAD \ "Initial basal levels were set by kf = 1, kb = 20. In model, though, the" \ "basal levels of PKC activity are higher." call /kinetics/chain/kinetics[13]/PKC/PKC-act-by-AA/notes LOAD \ "Raise kf from 1.667e-10 to 2e-10 to get better match to data." call /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[13]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[13]/PKC/PKC-n-DAG-AA/notes LOAD \ "Reduced kf to 0.66X to match Shinomura et al data." \ "Initial: kf = 3.3333e-9" \ "New: 2e-9" \ "Newer: 2e-8" \ "kb was 0.2" \ "now 2." call /kinetics/chain/kinetics[13]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[13]/PLA2/notes LOAD \ "Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270." \ "Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see" \ "Wijkander and Sundler JBC 202 (1991) pp873-880;" \ "Diez and Mong JBC 265(24) p14654;" \ "Leslie JBC 266(17) (1991) pp11366-11371" call /kinetics/chain/kinetics[13]/PLA2/PLA2-cytosolic/notes LOAD \ "Calculated cytosolic was 20 nm from Wijkander and Sundler" \ "However, Leslie and Channon use about 400 nM. Need to confirm," \ "but this is the value I use here. Another recalc of W&S gives 1uM" call /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca-act/notes LOAD \ "Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267." call /kinetics/chain/kinetics[13]/PLA2/PLA2-Ca*/kenz/notes LOAD \ "10 x raise oct22" \ "12 x oct 24, set k2 = 4 * k3" call /kinetics/chain/kinetics[13]/PLA2/PIP2-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X further raise oct 24 to allow for correct conc of enzyme" \ "" call /kinetics/chain/kinetics[13]/PLA2/PIP2-Ca-PLA2*/kenz/notes LOAD \ "10 x raise oct 22" \ "12 x and rescale for k2 = 4 * k3 convention oct 24" \ "Increase further to get the match to expt, which was spoilt due" \ "to large accumulation of PLA2 in the enzyme complexed forms." \ "Lets raise k3, leaving the others at " \ "k1 = 1.5e-5 and k2 = 144 since they are large already." \ "" call /kinetics/chain/kinetics[13]/PLA2/DAG-Ca-PLA2-act/notes LOAD \ "27 June 1996" \ "Scaled kf down by 0.015" \ "from 3.33e-7 to 5e-9" \ "to fit with revised DAG estimates" \ "and use of mole-fraction to calculate eff on PLA2." call /kinetics/chain/kinetics[13]/PLA2/DAG-Ca-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X raise oct 24 + conversion to k2 =4 * k3" call /kinetics/chain/kinetics[13]/PLA2/APC/notes LOAD \ "arachodonylphosphatidylcholine is the favoured substrate" \ "from Wijkander and Sundler, JBC 202 pp 873-880, 1991." \ "Their assay used 30 uM substrate, which is what the kinetics in" \ "this model are based on. For the later model we should locate" \ "a more realistic value for APC." call /kinetics/chain/kinetics[13]/PLA2/Degrade-AA/notes LOAD \ "I need to check if the AA degradation pathway really leads back to " \ "APC. Anyway, it is a convenient buffered pool to dump it back into." \ "For the purposes of the full model we use a rate of degradation of" \ "0.2/sec" \ "Raised decay to 0.4 : see PLA35.g notes for Feb17 " call /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca/notes LOAD \ "Phosphorylated form of PLA2. Still need to hook it up using kinases." \ "PKA: Wightman et al JBC 257 pp6650 1982" \ "PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal" \ "MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone" \ "Do not know if there is a Ca requirement for active phosphorylated state." call /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca/kenz/notes LOAD \ "This form should be 3 to 6 times as fast as the Ca-only form." \ "I have scaled by 4x which seems to give a 5x rise." \ "10x raise Oct 22" \ "12 x oct 24, changed k2 = 4 * k3" call /kinetics/chain/kinetics[13]/PLA2/PLA2*-Ca-act/notes LOAD \ "To start off, same kinetics as the PLA2-Ca-act direct pathway." \ "Oops ! Missed out the Ca input to this pathway first time round." \ "Let's raise the forward rate about 3x to 5e-6. This will let us reduce the" \ "rather high rates we have used for the kenz on PLA2*-Ca. In fact, it" \ "may be that the rates are not that different, just that this pathway for" \ "getting the PLA2 to the memb is more efficien...." call /kinetics/chain/kinetics[13]/temp-PIP2/notes LOAD \ "This isn't explicitly present in the M&L model, but is obviously needed." \ "I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim" \ "7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) " \ "Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs," \ "which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984" \ "Lets use a lower level of 30 nM, same ref...." call /kinetics/chain/kinetics[13]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[13]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[13]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[13]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[13]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[13]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[13]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[13]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[13]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[13]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[13]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[13]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[13]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[13]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[13]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[13]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[13]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[13]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[13]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[13]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[13]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[13]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" \ "28 Feb 2006: Increased affinity 36-fold to account for Ca" \ "input to MAPK cascade, possibly folding in other pathway" \ "inputs." \ "21 April 2006: Altered affinity to same level as " \ "pkm_mapk21.g model to prevent spontaneous turnon." \ "Kf = 200, Kb = 1." \ "" \ "" \ "" call /kinetics/chain/kinetics[13]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[13]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras" \ "" call /kinetics/chain/kinetics[13]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[13]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[13]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[13]/PKC-active/phosph-AC2/notes LOAD \ "Phorbol esters have little effect on AC1 or on the Gs-stimulation of" \ "AC2. So in this model we are only dealing with the increase in" \ "basal activation of AC2 induced by PKC" \ "k1 = 1.66e-6" \ "k2 = 16" \ "k3 =4" \ "" call /kinetics/chain/kinetics[13]/MAPK*/MAPK*/notes LOAD \ "Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate)" \ "Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so:" \ "k3 = .5/sec (rate limiting)" \ "k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1" \ "#s from Sanghera et al JBC 265 pp 52 , 1990. " \ "From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio" \ "of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5" call /kinetics/chain/kinetics[13]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[13]/IP3/notes LOAD \ "Peak IP3 is perhaps 15 uM, basal <= 0.2 uM." call /kinetics/chain/kinetics[13]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[13]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[13]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[13]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[13]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[13]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[13]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[13]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[13]/CaM/CaM-TR2-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)...." call /kinetics/chain/kinetics[13]/CaM/CaM-TR2-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[13]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[13]/CaM/CaM-TR2-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[13]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[14]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[14]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[14]/PKC/PKC-act-by-Ca-AA/notes LOAD \ "Schaechter and Benowitz We have to increase Kf for conc scaling" \ "Changed kf to 2e-9 on Sept 19, 94. This gives better match." \ "" call /kinetics/chain/kinetics[14]/PKC/PKC-act-by-DAG-AA/notes LOAD \ "Assume slowish too. Schaechter and Benowitz" call /kinetics/chain/kinetics[14]/PKC/PKC-basal-act/notes LOAD \ "Initial basal levels were set by kf = 1, kb = 20. In model, though, the" \ "basal levels of PKC activity are higher." call /kinetics/chain/kinetics[14]/PKC/PKC-act-by-AA/notes LOAD \ "Raise kf from 1.667e-10 to 2e-10 to get better match to data." call /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[14]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[14]/PKC/PKC-n-DAG-AA/notes LOAD \ "Reduced kf to 0.66X to match Shinomura et al data." \ "Initial: kf = 3.3333e-9" \ "New: 2e-9" \ "Newer: 2e-8" \ "kb was 0.2" \ "now 2." call /kinetics/chain/kinetics[14]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[14]/PLA2/notes LOAD \ "Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270." \ "Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see" \ "Wijkander and Sundler JBC 202 (1991) pp873-880;" \ "Diez and Mong JBC 265(24) p14654;" \ "Leslie JBC 266(17) (1991) pp11366-11371" call /kinetics/chain/kinetics[14]/PLA2/PLA2-cytosolic/notes LOAD \ "Calculated cytosolic was 20 nm from Wijkander and Sundler" \ "However, Leslie and Channon use about 400 nM. Need to confirm," \ "but this is the value I use here. Another recalc of W&S gives 1uM" call /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca-act/notes LOAD \ "Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267." call /kinetics/chain/kinetics[14]/PLA2/PLA2-Ca*/kenz/notes LOAD \ "10 x raise oct22" \ "12 x oct 24, set k2 = 4 * k3" call /kinetics/chain/kinetics[14]/PLA2/PIP2-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X further raise oct 24 to allow for correct conc of enzyme" \ "" call /kinetics/chain/kinetics[14]/PLA2/PIP2-Ca-PLA2*/kenz/notes LOAD \ "10 x raise oct 22" \ "12 x and rescale for k2 = 4 * k3 convention oct 24" \ "Increase further to get the match to expt, which was spoilt due" \ "to large accumulation of PLA2 in the enzyme complexed forms." \ "Lets raise k3, leaving the others at " \ "k1 = 1.5e-5 and k2 = 144 since they are large already." \ "" call /kinetics/chain/kinetics[14]/PLA2/DAG-Ca-PLA2-act/notes LOAD \ "27 June 1996" \ "Scaled kf down by 0.015" \ "from 3.33e-7 to 5e-9" \ "to fit with revised DAG estimates" \ "and use of mole-fraction to calculate eff on PLA2." call /kinetics/chain/kinetics[14]/PLA2/DAG-Ca-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X raise oct 24 + conversion to k2 =4 * k3" call /kinetics/chain/kinetics[14]/PLA2/APC/notes LOAD \ "arachodonylphosphatidylcholine is the favoured substrate" \ "from Wijkander and Sundler, JBC 202 pp 873-880, 1991." \ "Their assay used 30 uM substrate, which is what the kinetics in" \ "this model are based on. For the later model we should locate" \ "a more realistic value for APC." call /kinetics/chain/kinetics[14]/PLA2/Degrade-AA/notes LOAD \ "I need to check if the AA degradation pathway really leads back to " \ "APC. Anyway, it is a convenient buffered pool to dump it back into." \ "For the purposes of the full model we use a rate of degradation of" \ "0.2/sec" \ "Raised decay to 0.4 : see PLA35.g notes for Feb17 " call /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca/notes LOAD \ "Phosphorylated form of PLA2. Still need to hook it up using kinases." \ "PKA: Wightman et al JBC 257 pp6650 1982" \ "PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal" \ "MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone" \ "Do not know if there is a Ca requirement for active phosphorylated state." call /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca/kenz/notes LOAD \ "This form should be 3 to 6 times as fast as the Ca-only form." \ "I have scaled by 4x which seems to give a 5x rise." \ "10x raise Oct 22" \ "12 x oct 24, changed k2 = 4 * k3" call /kinetics/chain/kinetics[14]/PLA2/PLA2*-Ca-act/notes LOAD \ "To start off, same kinetics as the PLA2-Ca-act direct pathway." \ "Oops ! Missed out the Ca input to this pathway first time round." \ "Let's raise the forward rate about 3x to 5e-6. This will let us reduce the" \ "rather high rates we have used for the kenz on PLA2*-Ca. In fact, it" \ "may be that the rates are not that different, just that this pathway for" \ "getting the PLA2 to the memb is more efficien...." call /kinetics/chain/kinetics[14]/temp-PIP2/notes LOAD \ "This isn't explicitly present in the M&L model, but is obviously needed." \ "I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim" \ "7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) " \ "Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs," \ "which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984" \ "Lets use a lower level of 30 nM, same ref...." call /kinetics/chain/kinetics[14]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[14]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[14]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[14]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[14]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[14]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[14]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[14]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[14]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[14]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[14]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[14]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[14]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[14]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[14]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[14]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[14]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[14]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[14]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[14]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[14]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[14]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" \ "28 Feb 2006: Increased affinity 36-fold to account for Ca" \ "input to MAPK cascade, possibly folding in other pathway" \ "inputs." \ "21 April 2006: Altered affinity to same level as " \ "pkm_mapk21.g model to prevent spontaneous turnon." \ "Kf = 200, Kb = 1." \ "" \ "" \ "" call /kinetics/chain/kinetics[14]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[14]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras" \ "" call /kinetics/chain/kinetics[14]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[14]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[14]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[14]/PKC-active/phosph-AC2/notes LOAD \ "Phorbol esters have little effect on AC1 or on the Gs-stimulation of" \ "AC2. So in this model we are only dealing with the increase in" \ "basal activation of AC2 induced by PKC" \ "k1 = 1.66e-6" \ "k2 = 16" \ "k3 =4" \ "" call /kinetics/chain/kinetics[14]/MAPK*/MAPK*/notes LOAD \ "Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate)" \ "Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so:" \ "k3 = .5/sec (rate limiting)" \ "k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1" \ "#s from Sanghera et al JBC 265 pp 52 , 1990. " \ "From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio" \ "of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5" call /kinetics/chain/kinetics[14]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[14]/IP3/notes LOAD \ "Peak IP3 is perhaps 15 uM, basal <= 0.2 uM." call /kinetics/chain/kinetics[14]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[14]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[14]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[14]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[14]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[14]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[14]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[14]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[14]/CaM/CaM-TR2-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)...." call /kinetics/chain/kinetics[14]/CaM/CaM-TR2-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[14]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[14]/CaM/CaM-TR2-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[14]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[15]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[15]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[15]/PKC/PKC-act-by-Ca-AA/notes LOAD \ "Schaechter and Benowitz We have to increase Kf for conc scaling" \ "Changed kf to 2e-9 on Sept 19, 94. This gives better match." \ "" call /kinetics/chain/kinetics[15]/PKC/PKC-act-by-DAG-AA/notes LOAD \ "Assume slowish too. Schaechter and Benowitz" call /kinetics/chain/kinetics[15]/PKC/PKC-basal-act/notes LOAD \ "Initial basal levels were set by kf = 1, kb = 20. In model, though, the" \ "basal levels of PKC activity are higher." call /kinetics/chain/kinetics[15]/PKC/PKC-act-by-AA/notes LOAD \ "Raise kf from 1.667e-10 to 2e-10 to get better match to data." call /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[15]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[15]/PKC/PKC-n-DAG-AA/notes LOAD \ "Reduced kf to 0.66X to match Shinomura et al data." \ "Initial: kf = 3.3333e-9" \ "New: 2e-9" \ "Newer: 2e-8" \ "kb was 0.2" \ "now 2." call /kinetics/chain/kinetics[15]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[15]/PLA2/notes LOAD \ "Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270." \ "Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see" \ "Wijkander and Sundler JBC 202 (1991) pp873-880;" \ "Diez and Mong JBC 265(24) p14654;" \ "Leslie JBC 266(17) (1991) pp11366-11371" call /kinetics/chain/kinetics[15]/PLA2/PLA2-cytosolic/notes LOAD \ "Calculated cytosolic was 20 nm from Wijkander and Sundler" \ "However, Leslie and Channon use about 400 nM. Need to confirm," \ "but this is the value I use here. Another recalc of W&S gives 1uM" call /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca-act/notes LOAD \ "Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267." call /kinetics/chain/kinetics[15]/PLA2/PLA2-Ca*/kenz/notes LOAD \ "10 x raise oct22" \ "12 x oct 24, set k2 = 4 * k3" call /kinetics/chain/kinetics[15]/PLA2/PIP2-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X further raise oct 24 to allow for correct conc of enzyme" \ "" call /kinetics/chain/kinetics[15]/PLA2/PIP2-Ca-PLA2*/kenz/notes LOAD \ "10 x raise oct 22" \ "12 x and rescale for k2 = 4 * k3 convention oct 24" \ "Increase further to get the match to expt, which was spoilt due" \ "to large accumulation of PLA2 in the enzyme complexed forms." \ "Lets raise k3, leaving the others at " \ "k1 = 1.5e-5 and k2 = 144 since they are large already." \ "" call /kinetics/chain/kinetics[15]/PLA2/DAG-Ca-PLA2-act/notes LOAD \ "27 June 1996" \ "Scaled kf down by 0.015" \ "from 3.33e-7 to 5e-9" \ "to fit with revised DAG estimates" \ "and use of mole-fraction to calculate eff on PLA2." call /kinetics/chain/kinetics[15]/PLA2/DAG-Ca-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X raise oct 24 + conversion to k2 =4 * k3" call /kinetics/chain/kinetics[15]/PLA2/APC/notes LOAD \ "arachodonylphosphatidylcholine is the favoured substrate" \ "from Wijkander and Sundler, JBC 202 pp 873-880, 1991." \ "Their assay used 30 uM substrate, which is what the kinetics in" \ "this model are based on. For the later model we should locate" \ "a more realistic value for APC." call /kinetics/chain/kinetics[15]/PLA2/Degrade-AA/notes LOAD \ "I need to check if the AA degradation pathway really leads back to " \ "APC. Anyway, it is a convenient buffered pool to dump it back into." \ "For the purposes of the full model we use a rate of degradation of" \ "0.2/sec" \ "Raised decay to 0.4 : see PLA35.g notes for Feb17 " call /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca/notes LOAD \ "Phosphorylated form of PLA2. Still need to hook it up using kinases." \ "PKA: Wightman et al JBC 257 pp6650 1982" \ "PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal" \ "MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone" \ "Do not know if there is a Ca requirement for active phosphorylated state." call /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca/kenz/notes LOAD \ "This form should be 3 to 6 times as fast as the Ca-only form." \ "I have scaled by 4x which seems to give a 5x rise." \ "10x raise Oct 22" \ "12 x oct 24, changed k2 = 4 * k3" call /kinetics/chain/kinetics[15]/PLA2/PLA2*-Ca-act/notes LOAD \ "To start off, same kinetics as the PLA2-Ca-act direct pathway." \ "Oops ! Missed out the Ca input to this pathway first time round." \ "Let's raise the forward rate about 3x to 5e-6. This will let us reduce the" \ "rather high rates we have used for the kenz on PLA2*-Ca. In fact, it" \ "may be that the rates are not that different, just that this pathway for" \ "getting the PLA2 to the memb is more efficien...." call /kinetics/chain/kinetics[15]/temp-PIP2/notes LOAD \ "This isn't explicitly present in the M&L model, but is obviously needed." \ "I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim" \ "7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) " \ "Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs," \ "which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984" \ "Lets use a lower level of 30 nM, same ref...." call /kinetics/chain/kinetics[15]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[15]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[15]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[15]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[15]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[15]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[15]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[15]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[15]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[15]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[15]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[15]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[15]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[15]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[15]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[15]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[15]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[15]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[15]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[15]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[15]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[15]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" \ "28 Feb 2006: Increased affinity 36-fold to account for Ca" \ "input to MAPK cascade, possibly folding in other pathway" \ "inputs." \ "21 April 2006: Altered affinity to same level as " \ "pkm_mapk21.g model to prevent spontaneous turnon." \ "Kf = 200, Kb = 1." \ "" \ "" \ "" call /kinetics/chain/kinetics[15]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[15]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras" \ "" call /kinetics/chain/kinetics[15]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[15]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[15]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[15]/PKC-active/phosph-AC2/notes LOAD \ "Phorbol esters have little effect on AC1 or on the Gs-stimulation of" \ "AC2. So in this model we are only dealing with the increase in" \ "basal activation of AC2 induced by PKC" \ "k1 = 1.66e-6" \ "k2 = 16" \ "k3 =4" \ "" call /kinetics/chain/kinetics[15]/MAPK*/MAPK*/notes LOAD \ "Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate)" \ "Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so:" \ "k3 = .5/sec (rate limiting)" \ "k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1" \ "#s from Sanghera et al JBC 265 pp 52 , 1990. " \ "From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio" \ "of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5" call /kinetics/chain/kinetics[15]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[15]/IP3/notes LOAD \ "Peak IP3 is perhaps 15 uM, basal <= 0.2 uM." call /kinetics/chain/kinetics[15]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[15]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[15]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[15]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[15]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[15]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[15]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[15]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[15]/CaM/CaM-TR2-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)...." call /kinetics/chain/kinetics[15]/CaM/CaM-TR2-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[15]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[15]/CaM/CaM-TR2-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[15]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[16]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[16]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[16]/PKC/PKC-act-by-Ca-AA/notes LOAD \ "Schaechter and Benowitz We have to increase Kf for conc scaling" \ "Changed kf to 2e-9 on Sept 19, 94. This gives better match." \ "" call /kinetics/chain/kinetics[16]/PKC/PKC-act-by-DAG-AA/notes LOAD \ "Assume slowish too. Schaechter and Benowitz" call /kinetics/chain/kinetics[16]/PKC/PKC-basal-act/notes LOAD \ "Initial basal levels were set by kf = 1, kb = 20. In model, though, the" \ "basal levels of PKC activity are higher." call /kinetics/chain/kinetics[16]/PKC/PKC-act-by-AA/notes LOAD \ "Raise kf from 1.667e-10 to 2e-10 to get better match to data." call /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[16]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[16]/PKC/PKC-n-DAG-AA/notes LOAD \ "Reduced kf to 0.66X to match Shinomura et al data." \ "Initial: kf = 3.3333e-9" \ "New: 2e-9" \ "Newer: 2e-8" \ "kb was 0.2" \ "now 2." call /kinetics/chain/kinetics[16]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[16]/PLA2/notes LOAD \ "Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270." \ "Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see" \ "Wijkander and Sundler JBC 202 (1991) pp873-880;" \ "Diez and Mong JBC 265(24) p14654;" \ "Leslie JBC 266(17) (1991) pp11366-11371" call /kinetics/chain/kinetics[16]/PLA2/PLA2-cytosolic/notes LOAD \ "Calculated cytosolic was 20 nm from Wijkander and Sundler" \ "However, Leslie and Channon use about 400 nM. Need to confirm," \ "but this is the value I use here. Another recalc of W&S gives 1uM" call /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca-act/notes LOAD \ "Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267." call /kinetics/chain/kinetics[16]/PLA2/PLA2-Ca*/kenz/notes LOAD \ "10 x raise oct22" \ "12 x oct 24, set k2 = 4 * k3" call /kinetics/chain/kinetics[16]/PLA2/PIP2-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X further raise oct 24 to allow for correct conc of enzyme" \ "" call /kinetics/chain/kinetics[16]/PLA2/PIP2-Ca-PLA2*/kenz/notes LOAD \ "10 x raise oct 22" \ "12 x and rescale for k2 = 4 * k3 convention oct 24" \ "Increase further to get the match to expt, which was spoilt due" \ "to large accumulation of PLA2 in the enzyme complexed forms." \ "Lets raise k3, leaving the others at " \ "k1 = 1.5e-5 and k2 = 144 since they are large already." \ "" call /kinetics/chain/kinetics[16]/PLA2/DAG-Ca-PLA2-act/notes LOAD \ "27 June 1996" \ "Scaled kf down by 0.015" \ "from 3.33e-7 to 5e-9" \ "to fit with revised DAG estimates" \ "and use of mole-fraction to calculate eff on PLA2." call /kinetics/chain/kinetics[16]/PLA2/DAG-Ca-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X raise oct 24 + conversion to k2 =4 * k3" call /kinetics/chain/kinetics[16]/PLA2/APC/notes LOAD \ "arachodonylphosphatidylcholine is the favoured substrate" \ "from Wijkander and Sundler, JBC 202 pp 873-880, 1991." \ "Their assay used 30 uM substrate, which is what the kinetics in" \ "this model are based on. For the later model we should locate" \ "a more realistic value for APC." call /kinetics/chain/kinetics[16]/PLA2/Degrade-AA/notes LOAD \ "I need to check if the AA degradation pathway really leads back to " \ "APC. Anyway, it is a convenient buffered pool to dump it back into." \ "For the purposes of the full model we use a rate of degradation of" \ "0.2/sec" \ "Raised decay to 0.4 : see PLA35.g notes for Feb17 " call /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca/notes LOAD \ "Phosphorylated form of PLA2. Still need to hook it up using kinases." \ "PKA: Wightman et al JBC 257 pp6650 1982" \ "PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal" \ "MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone" \ "Do not know if there is a Ca requirement for active phosphorylated state." call /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca/kenz/notes LOAD \ "This form should be 3 to 6 times as fast as the Ca-only form." \ "I have scaled by 4x which seems to give a 5x rise." \ "10x raise Oct 22" \ "12 x oct 24, changed k2 = 4 * k3" call /kinetics/chain/kinetics[16]/PLA2/PLA2*-Ca-act/notes LOAD \ "To start off, same kinetics as the PLA2-Ca-act direct pathway." \ "Oops ! Missed out the Ca input to this pathway first time round." \ "Let's raise the forward rate about 3x to 5e-6. This will let us reduce the" \ "rather high rates we have used for the kenz on PLA2*-Ca. In fact, it" \ "may be that the rates are not that different, just that this pathway for" \ "getting the PLA2 to the memb is more efficien...." call /kinetics/chain/kinetics[16]/temp-PIP2/notes LOAD \ "This isn't explicitly present in the M&L model, but is obviously needed." \ "I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim" \ "7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) " \ "Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs," \ "which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984" \ "Lets use a lower level of 30 nM, same ref...." call /kinetics/chain/kinetics[16]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[16]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[16]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[16]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[16]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[16]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[16]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[16]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[16]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[16]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[16]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[16]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[16]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[16]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[16]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[16]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[16]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[16]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[16]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[16]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[16]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[16]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" \ "28 Feb 2006: Increased affinity 36-fold to account for Ca" \ "input to MAPK cascade, possibly folding in other pathway" \ "inputs." \ "21 April 2006: Altered affinity to same level as " \ "pkm_mapk21.g model to prevent spontaneous turnon." \ "Kf = 200, Kb = 1." \ "" \ "" \ "" call /kinetics/chain/kinetics[16]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[16]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras" \ "" call /kinetics/chain/kinetics[16]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[16]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[16]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[16]/PKC-active/phosph-AC2/notes LOAD \ "Phorbol esters have little effect on AC1 or on the Gs-stimulation of" \ "AC2. So in this model we are only dealing with the increase in" \ "basal activation of AC2 induced by PKC" \ "k1 = 1.66e-6" \ "k2 = 16" \ "k3 =4" \ "" call /kinetics/chain/kinetics[16]/MAPK*/MAPK*/notes LOAD \ "Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate)" \ "Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so:" \ "k3 = .5/sec (rate limiting)" \ "k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1" \ "#s from Sanghera et al JBC 265 pp 52 , 1990. " \ "From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio" \ "of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5" call /kinetics/chain/kinetics[16]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[16]/IP3/notes LOAD \ "Peak IP3 is perhaps 15 uM, basal <= 0.2 uM." call /kinetics/chain/kinetics[16]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[16]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[16]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[16]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[16]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[16]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[16]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[16]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[16]/CaM/CaM-TR2-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)...." call /kinetics/chain/kinetics[16]/CaM/CaM-TR2-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[16]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[16]/CaM/CaM-TR2-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[16]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[17]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[17]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[17]/PKC/PKC-act-by-Ca-AA/notes LOAD \ "Schaechter and Benowitz We have to increase Kf for conc scaling" \ "Changed kf to 2e-9 on Sept 19, 94. This gives better match." \ "" call /kinetics/chain/kinetics[17]/PKC/PKC-act-by-DAG-AA/notes LOAD \ "Assume slowish too. Schaechter and Benowitz" call /kinetics/chain/kinetics[17]/PKC/PKC-basal-act/notes LOAD \ "Initial basal levels were set by kf = 1, kb = 20. In model, though, the" \ "basal levels of PKC activity are higher." call /kinetics/chain/kinetics[17]/PKC/PKC-act-by-AA/notes LOAD \ "Raise kf from 1.667e-10 to 2e-10 to get better match to data." call /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[17]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[17]/PKC/PKC-n-DAG-AA/notes LOAD \ "Reduced kf to 0.66X to match Shinomura et al data." \ "Initial: kf = 3.3333e-9" \ "New: 2e-9" \ "Newer: 2e-8" \ "kb was 0.2" \ "now 2." call /kinetics/chain/kinetics[17]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[17]/PLA2/notes LOAD \ "Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270." \ "Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see" \ "Wijkander and Sundler JBC 202 (1991) pp873-880;" \ "Diez and Mong JBC 265(24) p14654;" \ "Leslie JBC 266(17) (1991) pp11366-11371" call /kinetics/chain/kinetics[17]/PLA2/PLA2-cytosolic/notes LOAD \ "Calculated cytosolic was 20 nm from Wijkander and Sundler" \ "However, Leslie and Channon use about 400 nM. Need to confirm," \ "but this is the value I use here. Another recalc of W&S gives 1uM" call /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca-act/notes LOAD \ "Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267." call /kinetics/chain/kinetics[17]/PLA2/PLA2-Ca*/kenz/notes LOAD \ "10 x raise oct22" \ "12 x oct 24, set k2 = 4 * k3" call /kinetics/chain/kinetics[17]/PLA2/PIP2-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X further raise oct 24 to allow for correct conc of enzyme" \ "" call /kinetics/chain/kinetics[17]/PLA2/PIP2-Ca-PLA2*/kenz/notes LOAD \ "10 x raise oct 22" \ "12 x and rescale for k2 = 4 * k3 convention oct 24" \ "Increase further to get the match to expt, which was spoilt due" \ "to large accumulation of PLA2 in the enzyme complexed forms." \ "Lets raise k3, leaving the others at " \ "k1 = 1.5e-5 and k2 = 144 since they are large already." \ "" call /kinetics/chain/kinetics[17]/PLA2/DAG-Ca-PLA2-act/notes LOAD \ "27 June 1996" \ "Scaled kf down by 0.015" \ "from 3.33e-7 to 5e-9" \ "to fit with revised DAG estimates" \ "and use of mole-fraction to calculate eff on PLA2." call /kinetics/chain/kinetics[17]/PLA2/DAG-Ca-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X raise oct 24 + conversion to k2 =4 * k3" call /kinetics/chain/kinetics[17]/PLA2/APC/notes LOAD \ "arachodonylphosphatidylcholine is the favoured substrate" \ "from Wijkander and Sundler, JBC 202 pp 873-880, 1991." \ "Their assay used 30 uM substrate, which is what the kinetics in" \ "this model are based on. For the later model we should locate" \ "a more realistic value for APC." call /kinetics/chain/kinetics[17]/PLA2/Degrade-AA/notes LOAD \ "I need to check if the AA degradation pathway really leads back to " \ "APC. Anyway, it is a convenient buffered pool to dump it back into." \ "For the purposes of the full model we use a rate of degradation of" \ "0.2/sec" \ "Raised decay to 0.4 : see PLA35.g notes for Feb17 " call /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca/notes LOAD \ "Phosphorylated form of PLA2. Still need to hook it up using kinases." \ "PKA: Wightman et al JBC 257 pp6650 1982" \ "PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal" \ "MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone" \ "Do not know if there is a Ca requirement for active phosphorylated state." call /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca/kenz/notes LOAD \ "This form should be 3 to 6 times as fast as the Ca-only form." \ "I have scaled by 4x which seems to give a 5x rise." \ "10x raise Oct 22" \ "12 x oct 24, changed k2 = 4 * k3" call /kinetics/chain/kinetics[17]/PLA2/PLA2*-Ca-act/notes LOAD \ "To start off, same kinetics as the PLA2-Ca-act direct pathway." \ "Oops ! Missed out the Ca input to this pathway first time round." \ "Let's raise the forward rate about 3x to 5e-6. This will let us reduce the" \ "rather high rates we have used for the kenz on PLA2*-Ca. In fact, it" \ "may be that the rates are not that different, just that this pathway for" \ "getting the PLA2 to the memb is more efficien...." call /kinetics/chain/kinetics[17]/temp-PIP2/notes LOAD \ "This isn't explicitly present in the M&L model, but is obviously needed." \ "I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim" \ "7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) " \ "Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs," \ "which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984" \ "Lets use a lower level of 30 nM, same ref...." call /kinetics/chain/kinetics[17]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[17]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[17]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[17]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[17]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[17]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[17]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[17]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[17]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[17]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[17]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[17]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[17]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[17]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[17]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[17]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[17]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[17]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[17]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[17]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[17]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[17]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" \ "28 Feb 2006: Increased affinity 36-fold to account for Ca" \ "input to MAPK cascade, possibly folding in other pathway" \ "inputs." \ "21 April 2006: Altered affinity to same level as " \ "pkm_mapk21.g model to prevent spontaneous turnon." \ "Kf = 200, Kb = 1." \ "" \ "" \ "" call /kinetics/chain/kinetics[17]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[17]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras" \ "" call /kinetics/chain/kinetics[17]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[17]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[17]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[17]/PKC-active/phosph-AC2/notes LOAD \ "Phorbol esters have little effect on AC1 or on the Gs-stimulation of" \ "AC2. So in this model we are only dealing with the increase in" \ "basal activation of AC2 induced by PKC" \ "k1 = 1.66e-6" \ "k2 = 16" \ "k3 =4" \ "" call /kinetics/chain/kinetics[17]/MAPK*/MAPK*/notes LOAD \ "Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate)" \ "Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so:" \ "k3 = .5/sec (rate limiting)" \ "k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1" \ "#s from Sanghera et al JBC 265 pp 52 , 1990. " \ "From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio" \ "of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5" call /kinetics/chain/kinetics[17]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[17]/IP3/notes LOAD \ "Peak IP3 is perhaps 15 uM, basal <= 0.2 uM." call /kinetics/chain/kinetics[17]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[17]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[17]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[17]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[17]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[17]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[17]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[17]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[17]/CaM/CaM-TR2-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)...." call /kinetics/chain/kinetics[17]/CaM/CaM-TR2-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[17]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[17]/CaM/CaM-TR2-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[17]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[18]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[18]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[18]/PKC/PKC-act-by-Ca-AA/notes LOAD \ "Schaechter and Benowitz We have to increase Kf for conc scaling" \ "Changed kf to 2e-9 on Sept 19, 94. This gives better match." \ "" call /kinetics/chain/kinetics[18]/PKC/PKC-act-by-DAG-AA/notes LOAD \ "Assume slowish too. Schaechter and Benowitz" call /kinetics/chain/kinetics[18]/PKC/PKC-basal-act/notes LOAD \ "Initial basal levels were set by kf = 1, kb = 20. In model, though, the" \ "basal levels of PKC activity are higher." call /kinetics/chain/kinetics[18]/PKC/PKC-act-by-AA/notes LOAD \ "Raise kf from 1.667e-10 to 2e-10 to get better match to data." call /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[18]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[18]/PKC/PKC-n-DAG-AA/notes LOAD \ "Reduced kf to 0.66X to match Shinomura et al data." \ "Initial: kf = 3.3333e-9" \ "New: 2e-9" \ "Newer: 2e-8" \ "kb was 0.2" \ "now 2." call /kinetics/chain/kinetics[18]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[18]/PLA2/notes LOAD \ "Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270." \ "Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see" \ "Wijkander and Sundler JBC 202 (1991) pp873-880;" \ "Diez and Mong JBC 265(24) p14654;" \ "Leslie JBC 266(17) (1991) pp11366-11371" call /kinetics/chain/kinetics[18]/PLA2/PLA2-cytosolic/notes LOAD \ "Calculated cytosolic was 20 nm from Wijkander and Sundler" \ "However, Leslie and Channon use about 400 nM. Need to confirm," \ "but this is the value I use here. Another recalc of W&S gives 1uM" call /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca-act/notes LOAD \ "Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267." call /kinetics/chain/kinetics[18]/PLA2/PLA2-Ca*/kenz/notes LOAD \ "10 x raise oct22" \ "12 x oct 24, set k2 = 4 * k3" call /kinetics/chain/kinetics[18]/PLA2/PIP2-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X further raise oct 24 to allow for correct conc of enzyme" \ "" call /kinetics/chain/kinetics[18]/PLA2/PIP2-Ca-PLA2*/kenz/notes LOAD \ "10 x raise oct 22" \ "12 x and rescale for k2 = 4 * k3 convention oct 24" \ "Increase further to get the match to expt, which was spoilt due" \ "to large accumulation of PLA2 in the enzyme complexed forms." \ "Lets raise k3, leaving the others at " \ "k1 = 1.5e-5 and k2 = 144 since they are large already." \ "" call /kinetics/chain/kinetics[18]/PLA2/DAG-Ca-PLA2-act/notes LOAD \ "27 June 1996" \ "Scaled kf down by 0.015" \ "from 3.33e-7 to 5e-9" \ "to fit with revised DAG estimates" \ "and use of mole-fraction to calculate eff on PLA2." call /kinetics/chain/kinetics[18]/PLA2/DAG-Ca-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X raise oct 24 + conversion to k2 =4 * k3" call /kinetics/chain/kinetics[18]/PLA2/APC/notes LOAD \ "arachodonylphosphatidylcholine is the favoured substrate" \ "from Wijkander and Sundler, JBC 202 pp 873-880, 1991." \ "Their assay used 30 uM substrate, which is what the kinetics in" \ "this model are based on. For the later model we should locate" \ "a more realistic value for APC." call /kinetics/chain/kinetics[18]/PLA2/Degrade-AA/notes LOAD \ "I need to check if the AA degradation pathway really leads back to " \ "APC. Anyway, it is a convenient buffered pool to dump it back into." \ "For the purposes of the full model we use a rate of degradation of" \ "0.2/sec" \ "Raised decay to 0.4 : see PLA35.g notes for Feb17 " call /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca/notes LOAD \ "Phosphorylated form of PLA2. Still need to hook it up using kinases." \ "PKA: Wightman et al JBC 257 pp6650 1982" \ "PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal" \ "MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone" \ "Do not know if there is a Ca requirement for active phosphorylated state." call /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca/kenz/notes LOAD \ "This form should be 3 to 6 times as fast as the Ca-only form." \ "I have scaled by 4x which seems to give a 5x rise." \ "10x raise Oct 22" \ "12 x oct 24, changed k2 = 4 * k3" call /kinetics/chain/kinetics[18]/PLA2/PLA2*-Ca-act/notes LOAD \ "To start off, same kinetics as the PLA2-Ca-act direct pathway." \ "Oops ! Missed out the Ca input to this pathway first time round." \ "Let's raise the forward rate about 3x to 5e-6. This will let us reduce the" \ "rather high rates we have used for the kenz on PLA2*-Ca. In fact, it" \ "may be that the rates are not that different, just that this pathway for" \ "getting the PLA2 to the memb is more efficien...." call /kinetics/chain/kinetics[18]/temp-PIP2/notes LOAD \ "This isn't explicitly present in the M&L model, but is obviously needed." \ "I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim" \ "7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) " \ "Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs," \ "which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984" \ "Lets use a lower level of 30 nM, same ref...." call /kinetics/chain/kinetics[18]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[18]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[18]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[18]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[18]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[18]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[18]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[18]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[18]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[18]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[18]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[18]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[18]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[18]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[18]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[18]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[18]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[18]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[18]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[18]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[18]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[18]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" \ "28 Feb 2006: Increased affinity 36-fold to account for Ca" \ "input to MAPK cascade, possibly folding in other pathway" \ "inputs." \ "21 April 2006: Altered affinity to same level as " \ "pkm_mapk21.g model to prevent spontaneous turnon." \ "Kf = 200, Kb = 1." \ "" \ "" \ "" call /kinetics/chain/kinetics[18]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[18]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras" \ "" call /kinetics/chain/kinetics[18]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[18]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[18]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[18]/PKC-active/phosph-AC2/notes LOAD \ "Phorbol esters have little effect on AC1 or on the Gs-stimulation of" \ "AC2. So in this model we are only dealing with the increase in" \ "basal activation of AC2 induced by PKC" \ "k1 = 1.66e-6" \ "k2 = 16" \ "k3 =4" \ "" call /kinetics/chain/kinetics[18]/MAPK*/MAPK*/notes LOAD \ "Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate)" \ "Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so:" \ "k3 = .5/sec (rate limiting)" \ "k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1" \ "#s from Sanghera et al JBC 265 pp 52 , 1990. " \ "From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio" \ "of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5" call /kinetics/chain/kinetics[18]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[18]/IP3/notes LOAD \ "Peak IP3 is perhaps 15 uM, basal <= 0.2 uM." call /kinetics/chain/kinetics[18]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[18]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[18]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[18]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[18]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[18]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[18]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[18]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[18]/CaM/CaM-TR2-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)...." call /kinetics/chain/kinetics[18]/CaM/CaM-TR2-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[18]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[18]/CaM/CaM-TR2-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[18]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[19]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[19]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[19]/PKC/PKC-act-by-Ca-AA/notes LOAD \ "Schaechter and Benowitz We have to increase Kf for conc scaling" \ "Changed kf to 2e-9 on Sept 19, 94. This gives better match." \ "" call /kinetics/chain/kinetics[19]/PKC/PKC-act-by-DAG-AA/notes LOAD \ "Assume slowish too. Schaechter and Benowitz" call /kinetics/chain/kinetics[19]/PKC/PKC-basal-act/notes LOAD \ "Initial basal levels were set by kf = 1, kb = 20. In model, though, the" \ "basal levels of PKC activity are higher." call /kinetics/chain/kinetics[19]/PKC/PKC-act-by-AA/notes LOAD \ "Raise kf from 1.667e-10 to 2e-10 to get better match to data." call /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[19]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[19]/PKC/PKC-n-DAG-AA/notes LOAD \ "Reduced kf to 0.66X to match Shinomura et al data." \ "Initial: kf = 3.3333e-9" \ "New: 2e-9" \ "Newer: 2e-8" \ "kb was 0.2" \ "now 2." call /kinetics/chain/kinetics[19]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[19]/PLA2/notes LOAD \ "Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270." \ "Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see" \ "Wijkander and Sundler JBC 202 (1991) pp873-880;" \ "Diez and Mong JBC 265(24) p14654;" \ "Leslie JBC 266(17) (1991) pp11366-11371" call /kinetics/chain/kinetics[19]/PLA2/PLA2-cytosolic/notes LOAD \ "Calculated cytosolic was 20 nm from Wijkander and Sundler" \ "However, Leslie and Channon use about 400 nM. Need to confirm," \ "but this is the value I use here. Another recalc of W&S gives 1uM" call /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca-act/notes LOAD \ "Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267." call /kinetics/chain/kinetics[19]/PLA2/PLA2-Ca*/kenz/notes LOAD \ "10 x raise oct22" \ "12 x oct 24, set k2 = 4 * k3" call /kinetics/chain/kinetics[19]/PLA2/PIP2-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X further raise oct 24 to allow for correct conc of enzyme" \ "" call /kinetics/chain/kinetics[19]/PLA2/PIP2-Ca-PLA2*/kenz/notes LOAD \ "10 x raise oct 22" \ "12 x and rescale for k2 = 4 * k3 convention oct 24" \ "Increase further to get the match to expt, which was spoilt due" \ "to large accumulation of PLA2 in the enzyme complexed forms." \ "Lets raise k3, leaving the others at " \ "k1 = 1.5e-5 and k2 = 144 since they are large already." \ "" call /kinetics/chain/kinetics[19]/PLA2/DAG-Ca-PLA2-act/notes LOAD \ "27 June 1996" \ "Scaled kf down by 0.015" \ "from 3.33e-7 to 5e-9" \ "to fit with revised DAG estimates" \ "and use of mole-fraction to calculate eff on PLA2." call /kinetics/chain/kinetics[19]/PLA2/DAG-Ca-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X raise oct 24 + conversion to k2 =4 * k3" call /kinetics/chain/kinetics[19]/PLA2/APC/notes LOAD \ "arachodonylphosphatidylcholine is the favoured substrate" \ "from Wijkander and Sundler, JBC 202 pp 873-880, 1991." \ "Their assay used 30 uM substrate, which is what the kinetics in" \ "this model are based on. For the later model we should locate" \ "a more realistic value for APC." call /kinetics/chain/kinetics[19]/PLA2/Degrade-AA/notes LOAD \ "I need to check if the AA degradation pathway really leads back to " \ "APC. Anyway, it is a convenient buffered pool to dump it back into." \ "For the purposes of the full model we use a rate of degradation of" \ "0.2/sec" \ "Raised decay to 0.4 : see PLA35.g notes for Feb17 " call /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca/notes LOAD \ "Phosphorylated form of PLA2. Still need to hook it up using kinases." \ "PKA: Wightman et al JBC 257 pp6650 1982" \ "PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal" \ "MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone" \ "Do not know if there is a Ca requirement for active phosphorylated state." call /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca/kenz/notes LOAD \ "This form should be 3 to 6 times as fast as the Ca-only form." \ "I have scaled by 4x which seems to give a 5x rise." \ "10x raise Oct 22" \ "12 x oct 24, changed k2 = 4 * k3" call /kinetics/chain/kinetics[19]/PLA2/PLA2*-Ca-act/notes LOAD \ "To start off, same kinetics as the PLA2-Ca-act direct pathway." \ "Oops ! Missed out the Ca input to this pathway first time round." \ "Let's raise the forward rate about 3x to 5e-6. This will let us reduce the" \ "rather high rates we have used for the kenz on PLA2*-Ca. In fact, it" \ "may be that the rates are not that different, just that this pathway for" \ "getting the PLA2 to the memb is more efficien...." call /kinetics/chain/kinetics[19]/temp-PIP2/notes LOAD \ "This isn't explicitly present in the M&L model, but is obviously needed." \ "I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim" \ "7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) " \ "Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs," \ "which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984" \ "Lets use a lower level of 30 nM, same ref...." call /kinetics/chain/kinetics[19]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[19]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[19]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[19]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[19]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[19]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[19]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[19]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[19]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[19]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[19]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[19]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[19]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[19]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[19]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[19]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[19]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[19]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[19]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[19]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[19]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[19]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" \ "28 Feb 2006: Increased affinity 36-fold to account for Ca" \ "input to MAPK cascade, possibly folding in other pathway" \ "inputs." \ "21 April 2006: Altered affinity to same level as " \ "pkm_mapk21.g model to prevent spontaneous turnon." \ "Kf = 200, Kb = 1." \ "" \ "" \ "" call /kinetics/chain/kinetics[19]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[19]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras" \ "" call /kinetics/chain/kinetics[19]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[19]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[19]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[19]/PKC-active/phosph-AC2/notes LOAD \ "Phorbol esters have little effect on AC1 or on the Gs-stimulation of" \ "AC2. So in this model we are only dealing with the increase in" \ "basal activation of AC2 induced by PKC" \ "k1 = 1.66e-6" \ "k2 = 16" \ "k3 =4" \ "" call /kinetics/chain/kinetics[19]/MAPK*/MAPK*/notes LOAD \ "Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate)" \ "Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so:" \ "k3 = .5/sec (rate limiting)" \ "k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1" \ "#s from Sanghera et al JBC 265 pp 52 , 1990. " \ "From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio" \ "of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5" call /kinetics/chain/kinetics[19]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[19]/IP3/notes LOAD \ "Peak IP3 is perhaps 15 uM, basal <= 0.2 uM." call /kinetics/chain/kinetics[19]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[19]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[19]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[19]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[19]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[19]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[19]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[19]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[19]/CaM/CaM-TR2-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)...." call /kinetics/chain/kinetics[19]/CaM/CaM-TR2-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[19]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[19]/CaM/CaM-TR2-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[19]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[20]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[20]/PKC/PKC-act-by-Ca-AA/notes LOAD \ "Schaechter and Benowitz We have to increase Kf for conc scaling" \ "Changed kf to 2e-9 on Sept 19, 94. This gives better match." \ "" call /kinetics/chain/kinetics[20]/PKC/PKC-act-by-DAG-AA/notes LOAD \ "Assume slowish too. Schaechter and Benowitz" call /kinetics/chain/kinetics[20]/PKC/PKC-basal-act/notes LOAD \ "Initial basal levels were set by kf = 1, kb = 20. In model, though, the" \ "basal levels of PKC activity are higher." call /kinetics/chain/kinetics[20]/PKC/PKC-act-by-AA/notes LOAD \ "Raise kf from 1.667e-10 to 2e-10 to get better match to data." call /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[20]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[20]/PKC/PKC-n-DAG-AA/notes LOAD \ "Reduced kf to 0.66X to match Shinomura et al data." \ "Initial: kf = 3.3333e-9" \ "New: 2e-9" \ "Newer: 2e-8" \ "kb was 0.2" \ "now 2." call /kinetics/chain/kinetics[20]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[20]/PLA2/notes LOAD \ "Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270." \ "Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see" \ "Wijkander and Sundler JBC 202 (1991) pp873-880;" \ "Diez and Mong JBC 265(24) p14654;" \ "Leslie JBC 266(17) (1991) pp11366-11371" call /kinetics/chain/kinetics[20]/PLA2/PLA2-cytosolic/notes LOAD \ "Calculated cytosolic was 20 nm from Wijkander and Sundler" \ "However, Leslie and Channon use about 400 nM. Need to confirm," \ "but this is the value I use here. Another recalc of W&S gives 1uM" call /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca-act/notes LOAD \ "Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267." call /kinetics/chain/kinetics[20]/PLA2/PLA2-Ca*/kenz/notes LOAD \ "10 x raise oct22" \ "12 x oct 24, set k2 = 4 * k3" call /kinetics/chain/kinetics[20]/PLA2/PIP2-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X further raise oct 24 to allow for correct conc of enzyme" \ "" call /kinetics/chain/kinetics[20]/PLA2/PIP2-Ca-PLA2*/kenz/notes LOAD \ "10 x raise oct 22" \ "12 x and rescale for k2 = 4 * k3 convention oct 24" \ "Increase further to get the match to expt, which was spoilt due" \ "to large accumulation of PLA2 in the enzyme complexed forms." \ "Lets raise k3, leaving the others at " \ "k1 = 1.5e-5 and k2 = 144 since they are large already." \ "" call /kinetics/chain/kinetics[20]/PLA2/DAG-Ca-PLA2-act/notes LOAD \ "27 June 1996" \ "Scaled kf down by 0.015" \ "from 3.33e-7 to 5e-9" \ "to fit with revised DAG estimates" \ "and use of mole-fraction to calculate eff on PLA2." call /kinetics/chain/kinetics[20]/PLA2/DAG-Ca-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X raise oct 24 + conversion to k2 =4 * k3" call /kinetics/chain/kinetics[20]/PLA2/APC/notes LOAD \ "arachodonylphosphatidylcholine is the favoured substrate" \ "from Wijkander and Sundler, JBC 202 pp 873-880, 1991." \ "Their assay used 30 uM substrate, which is what the kinetics in" \ "this model are based on. For the later model we should locate" \ "a more realistic value for APC." call /kinetics/chain/kinetics[20]/PLA2/Degrade-AA/notes LOAD \ "I need to check if the AA degradation pathway really leads back to " \ "APC. Anyway, it is a convenient buffered pool to dump it back into." \ "For the purposes of the full model we use a rate of degradation of" \ "0.2/sec" \ "Raised decay to 0.4 : see PLA35.g notes for Feb17 " call /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca/notes LOAD \ "Phosphorylated form of PLA2. Still need to hook it up using kinases." \ "PKA: Wightman et al JBC 257 pp6650 1982" \ "PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal" \ "MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone" \ "Do not know if there is a Ca requirement for active phosphorylated state." call /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca/kenz/notes LOAD \ "This form should be 3 to 6 times as fast as the Ca-only form." \ "I have scaled by 4x which seems to give a 5x rise." \ "10x raise Oct 22" \ "12 x oct 24, changed k2 = 4 * k3" call /kinetics/chain/kinetics[20]/PLA2/PLA2*-Ca-act/notes LOAD \ "To start off, same kinetics as the PLA2-Ca-act direct pathway." \ "Oops ! Missed out the Ca input to this pathway first time round." \ "Let's raise the forward rate about 3x to 5e-6. This will let us reduce the" \ "rather high rates we have used for the kenz on PLA2*-Ca. In fact, it" \ "may be that the rates are not that different, just that this pathway for" \ "getting the PLA2 to the memb is more efficien...." call /kinetics/chain/kinetics[20]/temp-PIP2/notes LOAD \ "This isn't explicitly present in the M&L model, but is obviously needed." \ "I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim" \ "7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) " \ "Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs," \ "which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984" \ "Lets use a lower level of 30 nM, same ref...." call /kinetics/chain/kinetics[20]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[20]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[20]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[20]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[20]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[20]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[20]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[20]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[20]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[20]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[20]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[20]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[20]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[20]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[20]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[20]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[20]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[20]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[20]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[20]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[20]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[20]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" \ "28 Feb 2006: Increased affinity 36-fold to account for Ca" \ "input to MAPK cascade, possibly folding in other pathway" \ "inputs." \ "21 April 2006: Altered affinity to same level as " \ "pkm_mapk21.g model to prevent spontaneous turnon." \ "Kf = 200, Kb = 1." \ "" \ "" \ "" call /kinetics/chain/kinetics[20]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[20]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras" \ "" call /kinetics/chain/kinetics[20]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[20]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[20]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[20]/PKC-active/phosph-AC2/notes LOAD \ "Phorbol esters have little effect on AC1 or on the Gs-stimulation of" \ "AC2. So in this model we are only dealing with the increase in" \ "basal activation of AC2 induced by PKC" \ "k1 = 1.66e-6" \ "k2 = 16" \ "k3 =4" \ "" call /kinetics/chain/kinetics[20]/MAPK*/MAPK*/notes LOAD \ "Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate)" \ "Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so:" \ "k3 = .5/sec (rate limiting)" \ "k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1" \ "#s from Sanghera et al JBC 265 pp 52 , 1990. " \ "From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio" \ "of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5" call /kinetics/chain/kinetics[20]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[20]/IP3/notes LOAD \ "Peak IP3 is perhaps 15 uM, basal <= 0.2 uM." call /kinetics/chain/kinetics[20]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[20]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[20]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[20]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[20]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[20]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[20]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[20]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[20]/CaM/CaM-TR2-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)...." call /kinetics/chain/kinetics[20]/CaM/CaM-TR2-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[20]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[20]/CaM/CaM-TR2-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[20]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[21]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[21]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[21]/PKC/PKC-act-by-Ca-AA/notes LOAD \ "Schaechter and Benowitz We have to increase Kf for conc scaling" \ "Changed kf to 2e-9 on Sept 19, 94. This gives better match." \ "" call /kinetics/chain/kinetics[21]/PKC/PKC-act-by-DAG-AA/notes LOAD \ "Assume slowish too. Schaechter and Benowitz" call /kinetics/chain/kinetics[21]/PKC/PKC-basal-act/notes LOAD \ "Initial basal levels were set by kf = 1, kb = 20. In model, though, the" \ "basal levels of PKC activity are higher." call /kinetics/chain/kinetics[21]/PKC/PKC-act-by-AA/notes LOAD \ "Raise kf from 1.667e-10 to 2e-10 to get better match to data." call /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[21]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[21]/PKC/PKC-n-DAG-AA/notes LOAD \ "Reduced kf to 0.66X to match Shinomura et al data." \ "Initial: kf = 3.3333e-9" \ "New: 2e-9" \ "Newer: 2e-8" \ "kb was 0.2" \ "now 2." call /kinetics/chain/kinetics[21]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[21]/PLA2/notes LOAD \ "Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270." \ "Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see" \ "Wijkander and Sundler JBC 202 (1991) pp873-880;" \ "Diez and Mong JBC 265(24) p14654;" \ "Leslie JBC 266(17) (1991) pp11366-11371" call /kinetics/chain/kinetics[21]/PLA2/PLA2-cytosolic/notes LOAD \ "Calculated cytosolic was 20 nm from Wijkander and Sundler" \ "However, Leslie and Channon use about 400 nM. Need to confirm," \ "but this is the value I use here. Another recalc of W&S gives 1uM" call /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca-act/notes LOAD \ "Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267." call /kinetics/chain/kinetics[21]/PLA2/PLA2-Ca*/kenz/notes LOAD \ "10 x raise oct22" \ "12 x oct 24, set k2 = 4 * k3" call /kinetics/chain/kinetics[21]/PLA2/PIP2-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X further raise oct 24 to allow for correct conc of enzyme" \ "" call /kinetics/chain/kinetics[21]/PLA2/PIP2-Ca-PLA2*/kenz/notes LOAD \ "10 x raise oct 22" \ "12 x and rescale for k2 = 4 * k3 convention oct 24" \ "Increase further to get the match to expt, which was spoilt due" \ "to large accumulation of PLA2 in the enzyme complexed forms." \ "Lets raise k3, leaving the others at " \ "k1 = 1.5e-5 and k2 = 144 since they are large already." \ "" call /kinetics/chain/kinetics[21]/PLA2/DAG-Ca-PLA2-act/notes LOAD \ "27 June 1996" \ "Scaled kf down by 0.015" \ "from 3.33e-7 to 5e-9" \ "to fit with revised DAG estimates" \ "and use of mole-fraction to calculate eff on PLA2." call /kinetics/chain/kinetics[21]/PLA2/DAG-Ca-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X raise oct 24 + conversion to k2 =4 * k3" call /kinetics/chain/kinetics[21]/PLA2/APC/notes LOAD \ "arachodonylphosphatidylcholine is the favoured substrate" \ "from Wijkander and Sundler, JBC 202 pp 873-880, 1991." \ "Their assay used 30 uM substrate, which is what the kinetics in" \ "this model are based on. For the later model we should locate" \ "a more realistic value for APC." call /kinetics/chain/kinetics[21]/PLA2/Degrade-AA/notes LOAD \ "I need to check if the AA degradation pathway really leads back to " \ "APC. Anyway, it is a convenient buffered pool to dump it back into." \ "For the purposes of the full model we use a rate of degradation of" \ "0.2/sec" \ "Raised decay to 0.4 : see PLA35.g notes for Feb17 " call /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca/notes LOAD \ "Phosphorylated form of PLA2. Still need to hook it up using kinases." \ "PKA: Wightman et al JBC 257 pp6650 1982" \ "PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal" \ "MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone" \ "Do not know if there is a Ca requirement for active phosphorylated state." call /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca/kenz/notes LOAD \ "This form should be 3 to 6 times as fast as the Ca-only form." \ "I have scaled by 4x which seems to give a 5x rise." \ "10x raise Oct 22" \ "12 x oct 24, changed k2 = 4 * k3" call /kinetics/chain/kinetics[21]/PLA2/PLA2*-Ca-act/notes LOAD \ "To start off, same kinetics as the PLA2-Ca-act direct pathway." \ "Oops ! Missed out the Ca input to this pathway first time round." \ "Let's raise the forward rate about 3x to 5e-6. This will let us reduce the" \ "rather high rates we have used for the kenz on PLA2*-Ca. In fact, it" \ "may be that the rates are not that different, just that this pathway for" \ "getting the PLA2 to the memb is more efficien...." call /kinetics/chain/kinetics[21]/temp-PIP2/notes LOAD \ "This isn't explicitly present in the M&L model, but is obviously needed." \ "I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim" \ "7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) " \ "Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs," \ "which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984" \ "Lets use a lower level of 30 nM, same ref...." call /kinetics/chain/kinetics[21]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[21]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[21]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[21]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[21]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[21]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[21]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[21]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[21]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[21]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[21]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[21]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[21]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[21]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[21]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[21]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[21]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[21]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[21]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[21]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[21]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[21]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" \ "28 Feb 2006: Increased affinity 36-fold to account for Ca" \ "input to MAPK cascade, possibly folding in other pathway" \ "inputs." \ "21 April 2006: Altered affinity to same level as " \ "pkm_mapk21.g model to prevent spontaneous turnon." \ "Kf = 200, Kb = 1." \ "" \ "" \ "" call /kinetics/chain/kinetics[21]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[21]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras" \ "" call /kinetics/chain/kinetics[21]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[21]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[21]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[21]/PKC-active/phosph-AC2/notes LOAD \ "Phorbol esters have little effect on AC1 or on the Gs-stimulation of" \ "AC2. So in this model we are only dealing with the increase in" \ "basal activation of AC2 induced by PKC" \ "k1 = 1.66e-6" \ "k2 = 16" \ "k3 =4" \ "" call /kinetics/chain/kinetics[21]/MAPK*/MAPK*/notes LOAD \ "Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate)" \ "Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so:" \ "k3 = .5/sec (rate limiting)" \ "k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1" \ "#s from Sanghera et al JBC 265 pp 52 , 1990. " \ "From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio" \ "of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5" call /kinetics/chain/kinetics[21]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[21]/IP3/notes LOAD \ "Peak IP3 is perhaps 15 uM, basal <= 0.2 uM." call /kinetics/chain/kinetics[21]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[21]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[21]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[21]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[21]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[21]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[21]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[21]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[21]/CaM/CaM-TR2-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)...." call /kinetics/chain/kinetics[21]/CaM/CaM-TR2-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[21]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[21]/CaM/CaM-TR2-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[21]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[22]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[22]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[22]/PKC/PKC-act-by-Ca-AA/notes LOAD \ "Schaechter and Benowitz We have to increase Kf for conc scaling" \ "Changed kf to 2e-9 on Sept 19, 94. This gives better match." \ "" call /kinetics/chain/kinetics[22]/PKC/PKC-act-by-DAG-AA/notes LOAD \ "Assume slowish too. Schaechter and Benowitz" call /kinetics/chain/kinetics[22]/PKC/PKC-basal-act/notes LOAD \ "Initial basal levels were set by kf = 1, kb = 20. In model, though, the" \ "basal levels of PKC activity are higher." call /kinetics/chain/kinetics[22]/PKC/PKC-act-by-AA/notes LOAD \ "Raise kf from 1.667e-10 to 2e-10 to get better match to data." call /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[22]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[22]/PKC/PKC-n-DAG-AA/notes LOAD \ "Reduced kf to 0.66X to match Shinomura et al data." \ "Initial: kf = 3.3333e-9" \ "New: 2e-9" \ "Newer: 2e-8" \ "kb was 0.2" \ "now 2." call /kinetics/chain/kinetics[22]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[22]/PLA2/notes LOAD \ "Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270." \ "Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see" \ "Wijkander and Sundler JBC 202 (1991) pp873-880;" \ "Diez and Mong JBC 265(24) p14654;" \ "Leslie JBC 266(17) (1991) pp11366-11371" call /kinetics/chain/kinetics[22]/PLA2/PLA2-cytosolic/notes LOAD \ "Calculated cytosolic was 20 nm from Wijkander and Sundler" \ "However, Leslie and Channon use about 400 nM. Need to confirm," \ "but this is the value I use here. Another recalc of W&S gives 1uM" call /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca-act/notes LOAD \ "Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267." call /kinetics/chain/kinetics[22]/PLA2/PLA2-Ca*/kenz/notes LOAD \ "10 x raise oct22" \ "12 x oct 24, set k2 = 4 * k3" call /kinetics/chain/kinetics[22]/PLA2/PIP2-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X further raise oct 24 to allow for correct conc of enzyme" \ "" call /kinetics/chain/kinetics[22]/PLA2/PIP2-Ca-PLA2*/kenz/notes LOAD \ "10 x raise oct 22" \ "12 x and rescale for k2 = 4 * k3 convention oct 24" \ "Increase further to get the match to expt, which was spoilt due" \ "to large accumulation of PLA2 in the enzyme complexed forms." \ "Lets raise k3, leaving the others at " \ "k1 = 1.5e-5 and k2 = 144 since they are large already." \ "" call /kinetics/chain/kinetics[22]/PLA2/DAG-Ca-PLA2-act/notes LOAD \ "27 June 1996" \ "Scaled kf down by 0.015" \ "from 3.33e-7 to 5e-9" \ "to fit with revised DAG estimates" \ "and use of mole-fraction to calculate eff on PLA2." call /kinetics/chain/kinetics[22]/PLA2/DAG-Ca-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X raise oct 24 + conversion to k2 =4 * k3" call /kinetics/chain/kinetics[22]/PLA2/APC/notes LOAD \ "arachodonylphosphatidylcholine is the favoured substrate" \ "from Wijkander and Sundler, JBC 202 pp 873-880, 1991." \ "Their assay used 30 uM substrate, which is what the kinetics in" \ "this model are based on. For the later model we should locate" \ "a more realistic value for APC." call /kinetics/chain/kinetics[22]/PLA2/Degrade-AA/notes LOAD \ "I need to check if the AA degradation pathway really leads back to " \ "APC. Anyway, it is a convenient buffered pool to dump it back into." \ "For the purposes of the full model we use a rate of degradation of" \ "0.2/sec" \ "Raised decay to 0.4 : see PLA35.g notes for Feb17 " call /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca/notes LOAD \ "Phosphorylated form of PLA2. Still need to hook it up using kinases." \ "PKA: Wightman et al JBC 257 pp6650 1982" \ "PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal" \ "MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone" \ "Do not know if there is a Ca requirement for active phosphorylated state." call /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca/kenz/notes LOAD \ "This form should be 3 to 6 times as fast as the Ca-only form." \ "I have scaled by 4x which seems to give a 5x rise." \ "10x raise Oct 22" \ "12 x oct 24, changed k2 = 4 * k3" call /kinetics/chain/kinetics[22]/PLA2/PLA2*-Ca-act/notes LOAD \ "To start off, same kinetics as the PLA2-Ca-act direct pathway." \ "Oops ! Missed out the Ca input to this pathway first time round." \ "Let's raise the forward rate about 3x to 5e-6. This will let us reduce the" \ "rather high rates we have used for the kenz on PLA2*-Ca. In fact, it" \ "may be that the rates are not that different, just that this pathway for" \ "getting the PLA2 to the memb is more efficien...." call /kinetics/chain/kinetics[22]/temp-PIP2/notes LOAD \ "This isn't explicitly present in the M&L model, but is obviously needed." \ "I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim" \ "7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) " \ "Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs," \ "which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984" \ "Lets use a lower level of 30 nM, same ref...." call /kinetics/chain/kinetics[22]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[22]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[22]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[22]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[22]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[22]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[22]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[22]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[22]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[22]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[22]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[22]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[22]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[22]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[22]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[22]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[22]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[22]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[22]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[22]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[22]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[22]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" \ "28 Feb 2006: Increased affinity 36-fold to account for Ca" \ "input to MAPK cascade, possibly folding in other pathway" \ "inputs." \ "21 April 2006: Altered affinity to same level as " \ "pkm_mapk21.g model to prevent spontaneous turnon." \ "Kf = 200, Kb = 1." \ "" \ "" \ "" call /kinetics/chain/kinetics[22]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[22]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras" \ "" call /kinetics/chain/kinetics[22]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[22]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[22]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[22]/PKC-active/phosph-AC2/notes LOAD \ "Phorbol esters have little effect on AC1 or on the Gs-stimulation of" \ "AC2. So in this model we are only dealing with the increase in" \ "basal activation of AC2 induced by PKC" \ "k1 = 1.66e-6" \ "k2 = 16" \ "k3 =4" \ "" call /kinetics/chain/kinetics[22]/MAPK*/MAPK*/notes LOAD \ "Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate)" \ "Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so:" \ "k3 = .5/sec (rate limiting)" \ "k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1" \ "#s from Sanghera et al JBC 265 pp 52 , 1990. " \ "From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio" \ "of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5" call /kinetics/chain/kinetics[22]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[22]/IP3/notes LOAD \ "Peak IP3 is perhaps 15 uM, basal <= 0.2 uM." call /kinetics/chain/kinetics[22]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[22]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[22]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[22]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[22]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[22]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[22]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[22]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[22]/CaM/CaM-TR2-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)...." call /kinetics/chain/kinetics[22]/CaM/CaM-TR2-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[22]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[22]/CaM/CaM-TR2-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[22]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca/notes LOAD \ "Need est of rate of assoc of Ca and PKC. Assume it is fast" \ "The original parameter-searched kf of 439.4 has been" \ "scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085" \ "Raised kf to 1e-6 to match Ca curve, kb to .5" \ "" call /kinetics/chain/kinetics[23]/PKC/PKC-act-by-DAG/notes LOAD \ "Need est of rate. Assume it is fast" \ "Obtained from param search" \ "kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991." \ "kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of" \ "Shinomura data." \ "26 June 1996: Corrected DAG data: reduce kf 15x from " \ "2e-7 to 1.333e-8" call /kinetics/chain/kinetics[23]/PKC/PKC-DAG-to-memb/notes LOAD \ "Raise kb from .087 to 0.1 to match data from Shinomura et al." \ "Lower kf from 1.155 to 1.0 to match data from Shinomura et al." call /kinetics/chain/kinetics[23]/PKC/PKC-act-by-Ca-AA/notes LOAD \ "Schaechter and Benowitz We have to increase Kf for conc scaling" \ "Changed kf to 2e-9 on Sept 19, 94. This gives better match." \ "" call /kinetics/chain/kinetics[23]/PKC/PKC-act-by-DAG-AA/notes LOAD \ "Assume slowish too. Schaechter and Benowitz" call /kinetics/chain/kinetics[23]/PKC/PKC-basal-act/notes LOAD \ "Initial basal levels were set by kf = 1, kb = 20. In model, though, the" \ "basal levels of PKC activity are higher." call /kinetics/chain/kinetics[23]/PKC/PKC-act-by-AA/notes LOAD \ "Raise kf from 1.667e-10 to 2e-10 to get better match to data." call /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG/notes LOAD \ "kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991" \ "closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8)." \ "Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8" \ "26 June 1996: Corrected DAG levels: reduce kf by 15x from" \ "1.5e-8 to 1e-9" call /kinetics/chain/kinetics[23]/PKC/PKC-DAG/notes LOAD \ "CoInit was .0624" \ "" call /kinetics/chain/kinetics[23]/PKC/PKC-n-DAG-AA/notes LOAD \ "Reduced kf to 0.66X to match Shinomura et al data." \ "Initial: kf = 3.3333e-9" \ "New: 2e-9" \ "Newer: 2e-8" \ "kb was 0.2" \ "now 2." call /kinetics/chain/kinetics[23]/PKC/PKC-cytosolic/notes LOAD \ "Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells" \ "We will use 1 uM as our initial concen" \ "" call /kinetics/chain/kinetics[23]/PLA2/notes LOAD \ "Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270." \ "Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see" \ "Wijkander and Sundler JBC 202 (1991) pp873-880;" \ "Diez and Mong JBC 265(24) p14654;" \ "Leslie JBC 266(17) (1991) pp11366-11371" call /kinetics/chain/kinetics[23]/PLA2/PLA2-cytosolic/notes LOAD \ "Calculated cytosolic was 20 nm from Wijkander and Sundler" \ "However, Leslie and Channon use about 400 nM. Need to confirm," \ "but this is the value I use here. Another recalc of W&S gives 1uM" call /kinetics/chain/kinetics[23]/PLA2/PLA2-Ca-act/notes LOAD \ "Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267." call /kinetics/chain/kinetics[23]/PLA2/PLA2-Ca*/kenz/notes LOAD \ "10 x raise oct22" \ "12 x oct 24, set k2 = 4 * k3" call /kinetics/chain/kinetics[23]/PLA2/PIP2-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X further raise oct 24 to allow for correct conc of enzyme" \ "" call /kinetics/chain/kinetics[23]/PLA2/PIP2-Ca-PLA2*/kenz/notes LOAD \ "10 x raise oct 22" \ "12 x and rescale for k2 = 4 * k3 convention oct 24" \ "Increase further to get the match to expt, which was spoilt due" \ "to large accumulation of PLA2 in the enzyme complexed forms." \ "Lets raise k3, leaving the others at " \ "k1 = 1.5e-5 and k2 = 144 since they are large already." \ "" call /kinetics/chain/kinetics[23]/PLA2/DAG-Ca-PLA2-act/notes LOAD \ "27 June 1996" \ "Scaled kf down by 0.015" \ "from 3.33e-7 to 5e-9" \ "to fit with revised DAG estimates" \ "and use of mole-fraction to calculate eff on PLA2." call /kinetics/chain/kinetics[23]/PLA2/DAG-Ca-PLA2*/kenz/notes LOAD \ "10 X raise oct 22" \ "12 X raise oct 24 + conversion to k2 =4 * k3" call /kinetics/chain/kinetics[23]/PLA2/APC/notes LOAD \ "arachodonylphosphatidylcholine is the favoured substrate" \ "from Wijkander and Sundler, JBC 202 pp 873-880, 1991." \ "Their assay used 30 uM substrate, which is what the kinetics in" \ "this model are based on. For the later model we should locate" \ "a more realistic value for APC." call /kinetics/chain/kinetics[23]/PLA2/Degrade-AA/notes LOAD \ "I need to check if the AA degradation pathway really leads back to " \ "APC. Anyway, it is a convenient buffered pool to dump it back into." \ "For the purposes of the full model we use a rate of degradation of" \ "0.2/sec" \ "Raised decay to 0.4 : see PLA35.g notes for Feb17 " call /kinetics/chain/kinetics[23]/PLA2/PLA2*-Ca/notes LOAD \ "Phosphorylated form of PLA2. Still need to hook it up using kinases." \ "PKA: Wightman et al JBC 257 pp6650 1982" \ "PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal" \ "MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone" \ "Do not know if there is a Ca requirement for active phosphorylated state." call /kinetics/chain/kinetics[23]/PLA2/PLA2*-Ca/kenz/notes LOAD \ "This form should be 3 to 6 times as fast as the Ca-only form." \ "I have scaled by 4x which seems to give a 5x rise." \ "10x raise Oct 22" \ "12 x oct 24, changed k2 = 4 * k3" call /kinetics/chain/kinetics[23]/PLA2/PLA2*-Ca-act/notes LOAD \ "To start off, same kinetics as the PLA2-Ca-act direct pathway." \ "Oops ! Missed out the Ca input to this pathway first time round." \ "Let's raise the forward rate about 3x to 5e-6. This will let us reduce the" \ "rather high rates we have used for the kenz on PLA2*-Ca. In fact, it" \ "may be that the rates are not that different, just that this pathway for" \ "getting the PLA2 to the memb is more efficien...." call /kinetics/chain/kinetics[23]/temp-PIP2/notes LOAD \ "This isn't explicitly present in the M&L model, but is obviously needed." \ "I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim" \ "7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) " \ "Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs," \ "which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984" \ "Lets use a lower level of 30 nM, same ref...." call /kinetics/chain/kinetics[23]/MAPK/craf-1/notes LOAD \ "Couldn't find any ref to the actual conc of craf-1 but I" \ "should try Strom et al Oncogene 5 pp 345" \ "In line with the other kinases in the cascade, I estimate the conc to be" \ "0.2 uM. To init we use 0.15, which is close to equil" \ "16 May 2003: Changing to synaptic levels. Increasing 2.5 fold to 0.5 uM." \ "See Mihaly et al 1991 Brain Res 547(2):309-14" \ "and " \ "Morice et al 1999 Eur J Neurosci 11(6):1995-2006" call /kinetics/chain/kinetics[23]/MAPK/MAPKK/notes LOAD \ "Conc is from Seger et al JBC 267:20 pp14373 (1992)" \ "mwt is 45/46 Kd" \ "We assume that phosphorylation on both ser and thr is needed for" \ "activiation. See Kyriakis et al Nature 358 417 1992" \ "Init conc of total is 0.18" \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 suggest that levels are" \ "higher in hippocampus than other brain regions, and further elevated " \ "in synapses. Estimate 3x higher levels than before, at 0.5 uM." \ "Similar results from Schipper et al 1999 Neuroscience 93(2):585-595" \ "but again lacking in quantitation." call /kinetics/chain/kinetics[23]/MAPK/MAPK/notes LOAD \ "conc is from Sanghera et al JBC 265 pp 52 (1990)" \ "A second calculation gives 3.1 uM, from same paper." \ "They est MAPK is 1e-4x total protein, and protein is 15% of cell wt," \ "so MAPK is 1.5e-5g/ml = 0.36uM. which is closer to our first estimate." \ "Lets use this." \ "Updated 16 May 2003." \ "Ortiz et al 1995 J Neurosci 15(2):1285-1297 provide estimates of " \ "ERK2 levels in hippocampus: 1009 ng/mg. This comes to about 3.6uM, which" \ "may still be an underestimate of synaptic levels." call /kinetics/chain/kinetics[23]/MAPK/craf-1**/notes LOAD \ "Negative feedback by MAPK* by hyperphosphorylating craf-1* gives" \ "rise to this pool." \ "Ueki et al JBC 269(22):15756-15761, 1994" \ "" call /kinetics/chain/kinetics[23]/MAPK/MAPK-tyr/notes LOAD \ "Haystead et al FEBS Lett. 306(1) pp 17-22 show that phosphorylation" \ "is strictly sequential, first tyr185 then thr183." call /kinetics/chain/kinetics[23]/MAPK/MAPKK*/notes LOAD \ "MAPKK phosphorylates MAPK on both the tyr and thr residues, first" \ "tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992" \ "The MAPKK itself is phosphorylated on ser as well as thr residues." \ "Let us assume that the ser goes first, and that the sequential phosphorylation" \ "is needed. See Kyriakis et al Nature 358 417-421 1992" call /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKtyr/notes LOAD \ "The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992)" \ "Vmax = 150nmol/min/mg" \ "From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one" \ "of the phosphs." \ "Putting these together:" \ "k3=0.15/sec, scale to get k2=0.6." \ "k1=0.75/46.6nM=2.7e-5" call /kinetics/chain/kinetics[23]/MAPK/MAPKK*/MAPKKthr/notes LOAD \ "Rate consts same as for MAPKKtyr." call /kinetics/chain/kinetics[23]/MAPK/MAPKK-ser/notes LOAD \ "Intermediately phophorylated, assumed inactive, form of MAPKK" call /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[23]/MAPK/Raf-GTP-Ras/Raf-GTP-Ras.2/notes LOAD \ "Kinetics are the same as for the craf_1* activity, ie., " \ "k1=5.5e-6, k2=0.42, k3 = 0.105" \ "These are basedo n Force et al PNAS USA 91 1270-1274, 1994.," \ "but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here" \ "and for craf_1* activity: Km = 0.1591)." call /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.1/notes LOAD \ "Kinetics are the same as for the craf-1* activity, ie.," \ "k1=1.1e-6, k2=.42, k3 =0.105" \ "These are based on Force et al PNAS USA 91 1270-1274 1994." \ "These parms cannot reach the observed 4X stim of MAPK. So lets" \ "increase the affinity, ie, raise k1 10X to 1.1e-5" \ "Lets take it back down to where it was." \ "Back up to 5X: 5.5e-6" call /kinetics/chain/kinetics[23]/MAPK/Raf*-GTP-Ras/Raf*-GTP-Ras.2/notes LOAD \ "Same kinetics as other c-raf activated forms. See " \ "Force et al PNAS 91 1270-1274 1994." \ "k1 = 1.1e-6, k2 = .42, k3 = 1.05" \ "raise k1 to 5.5e-6" \ "" call /kinetics/chain/kinetics[23]/Ras-act-craf/notes LOAD \ "Assume the binding is fast and limited only by the amount of " \ "Ras* available. So kf=kb/[craf-1]" \ "If kb is 1/sec, then kf = 1/0.2 uM = 1/(0.2 * 6e5) = 8.3e-6" \ "Later: Raise it by 10 X to 4e-5" \ "From Hallberg et al JBC 269:6 3913-3916 1994, 3% of cellular Raf is" \ "complexed with Ras. So we raise kb 4x to 4" \ "This step needed to memb-anchor and activate Raf: Leevers et al Nature" \ "369 411-414" \ "May 16, 2003" \ "Changed Ras and Raf to synaptic levels, an increase of about 2x for each." \ "To maintain the percentage of complexed Raf, reduced the kf by 2.4 fold" \ "to 10." \ "" call /kinetics/chain/kinetics[23]/Ras/notes LOAD \ "Ras has now gotten to be a big enough component of the model to" \ "deserve its own group. The main refs are" \ "Boguski and McCormick Nature 366 643-654 '93 Major review" \ "Eccleston et al JBC 268:36 pp 27012-19" \ "Orita et al JBC 268:34 2554246" call /kinetics/chain/kinetics[23]/Ras/inact-GEF/notes LOAD \ "Assume that SoS is present only at 50 nM." \ "Revised to 100 nM to get equil to experimentally known levels." call /kinetics/chain/kinetics[23]/Ras/GEF*/notes LOAD \ "phosphorylated and thereby activated form of GEF. See, e.g." \ "Orita et al JBC 268:34 25542-25546 1993, Gulbins et al." \ "It is not clear whether there is major specificity for tyr or ser/thr." call /kinetics/chain/kinetics[23]/Ras/GEF*/GEF*-act-ras/notes LOAD \ "Kinetics same as GEF-bg-act-ras" \ "" call /kinetics/chain/kinetics[23]/Ras/GTP-Ras/notes LOAD \ "Only a very small fraction (7% unstim, 15% stim) of ras is GTP-bound." \ "Gibbs et al JBC 265(33) 20437" \ "" call /kinetics/chain/kinetics[23]/Ras/GDP-Ras/notes LOAD \ "GDP bound form. See Rosen et al Neuron 12 1207-1221 June 1994." \ "the activation loop is based on Boguski and McCormick Nature 366 643-654 93" \ "Assume Ras is present at about the same level as craf-1, 0.2 uM." \ "Hallberg et al JBC 269:6 3913-3916 1994 estimate upto 5-10% of cellular" \ "Raf is assoc with Ras. Given that only 5-10% of Ras is GTP-bound, we" \ "need similar amounts of Ras as Raf." call /kinetics/chain/kinetics[23]/Ras/Ras-intrinsic-GTPase/notes LOAD \ "This is extremely slow (1e-4), but it is significant as so little GAP actually" \ "gets complexed with it that the total GTP turnover rises only by" \ "2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and " \ "Eccleston et al JBC 268(36) 27012-27019" \ "kf = 1e-4" \ "" call /kinetics/chain/kinetics[23]/Ras/dephosph-GAP/notes LOAD \ "Assume a reasonably good rate for dephosphorylating it, 1/sec" call /kinetics/chain/kinetics[23]/Ras/GAP/notes LOAD \ "GTPase-activating proteins. See Boguski and McCormick." \ "Turn off Ras by helping to hydrolyze bound GTP. " \ "This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids," \ "and expressed in neural cells. p120-GAP is also a possible candidate, but" \ "is less regulated. Both may exist at similar levels." \ "See Eccleston et al JBC 268(36) pp27012-19" \ "Level=.002" \ "16 May 2003: Increased level to 0.0036, in line with other concentration" \ "raises at the synapse." call /kinetics/chain/kinetics[23]/Ras/GAP/GAP-inact-ras/notes LOAD \ "From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec" \ "From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min" \ "I will go with the Eccleston figures as there are good error bars (10%). In general" \ "the values are reasonably close." \ "k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting)" \ "5 Nov 2002: Changed ratio term to 4 from 100. Now we have" \ "k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting." call /kinetics/chain/kinetics[23]/Ras/CaM-bind-GEF/notes LOAD \ "We have no numbers for this. It is probably between" \ "the two extremes represented by the CaMKII phosph states," \ "and I have used guesses based on this." \ "kf=1e-4" \ "kb=1" \ "The reaction is based on Farnsworth et al Nature 376 524-527" \ "1995" \ "28 Feb 2006: Increased affinity 36-fold to account for Ca" \ "input to MAPK cascade, possibly folding in other pathway" \ "inputs." \ "21 April 2006: Altered affinity to same level as " \ "pkm_mapk21.g model to prevent spontaneous turnon." \ "Kf = 200, Kb = 1." \ "" \ "" \ "" call /kinetics/chain/kinetics[23]/Ras/CaM-GEF/notes LOAD \ "See Farnsworth et al Nature 376 524-527 1995" call /kinetics/chain/kinetics[23]/Ras/CaM-GEF/CaM-GEF-act-ras/notes LOAD \ "Kinetics same as GEF-bg_act-ras" \ "" call /kinetics/chain/kinetics[23]/PKC-active/PKC-act-raf/notes LOAD \ "Rate consts from Chen et al Biochem 32, 1032 (1993)" \ "k3 = k2 = 4" \ "k1 = 9e-5" \ "recalculated gives 1.666e-5, which is not very different." \ "Looks like k3 is rate-limiting in this case: there is a huge amount" \ "of craf locked up in the enz complex. Let us assume a 10x" \ "higher Km, ie, lower affinity. k1 drops by 10x." \ "Also changed k2 to 4x k3." \ "Lowerd k1 to 1e-6 to balance 10X DAG sensitivity of PKC" call /kinetics/chain/kinetics[23]/PKC-active/PKC-inact-GAP/notes LOAD \ "Rate consts copied from PCK-act-raf" \ "This reaction inactivates GAP. The idea is from the " \ "Boguski and McCormick review." call /kinetics/chain/kinetics[23]/PKC-active/PKC-act-GEF/notes LOAD \ "Rate consts from PKC-act-raf." \ "This reaction activates GEF. It can lead to at least 2X stim of ras, and" \ "a 2X stim of MAPK over and above that obtained via direct phosph of" \ "c-raf. Note that it is a push-pull reaction, and there is also a contribution" \ "through the phosphorylation and inactivation of GAPs." \ "The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X" call /kinetics/chain/kinetics[23]/PKC-active/phosph-AC2/notes LOAD \ "Phorbol esters have little effect on AC1 or on the Gs-stimulation of" \ "AC2. So in this model we are only dealing with the increase in" \ "basal activation of AC2 induced by PKC" \ "k1 = 1.66e-6" \ "k2 = 16" \ "k3 =4" \ "" call /kinetics/chain/kinetics[23]/MAPK*/MAPK*/notes LOAD \ "Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate)" \ "Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so:" \ "k3 = .5/sec (rate limiting)" \ "k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1" \ "#s from Sanghera et al JBC 265 pp 52 , 1990. " \ "From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio" \ "of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5" call /kinetics/chain/kinetics[23]/MAPK*/MAPK*-feedback/notes LOAD \ "Ueki et al JBC 269(22):15756-15761 show the presence of" \ "this step, but not the rate consts, which are derived from" \ "Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the" \ "MAPK* notes." call /kinetics/chain/kinetics[23]/IP3/notes LOAD \ "Peak IP3 is perhaps 15 uM, basal <= 0.2 uM." call /kinetics/chain/kinetics[23]/MKP-1/notes LOAD \ "MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 " \ "487-493 1993. Levels of MKP-1" \ "are regulated, and rise in 1 hour. " \ "Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer" \ "to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134" \ "is 40 min. 80% deph of MAPK in 20 min" \ "Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches" \ "from jun96 on." call /kinetics/chain/kinetics[23]/MKP-1/MKP1-tyr-deph/notes LOAD \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. As noted in the NOTES, the only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies. It would be nice to have more accurate estimates of" \ "rate consts and MKP-1 levels from the literature. " \ "Effective Km : 67 nM" \ "kcat = 1.43 umol/min/mg" call /kinetics/chain/kinetics[23]/MKP-1/MKP1-thr-deph/notes LOAD \ "See MKP1-tyr-deph" call /kinetics/chain/kinetics[23]/PPhosphatase2A/notes LOAD \ "Refs: Pato et al Biochem J 293:35-41(93);" \ "Takai&Mieskes Biochem J 275:233-239" \ "k1=1.46e-4, k2=1000,k3=250. these use" \ "kcat values for calponin. Also, units of kcat may be in min!" \ "revert to Vmax base:" \ "k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6" \ "CoInit assumed 0.1 uM." \ "See NOTES for MAPK_Ras50.g. CoInit now 0.08" \ "Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm" \ "searches from jun 96 on." \ "" call /kinetics/chain/kinetics[23]/PPhosphatase2A/craf-deph/notes LOAD \ "See parent PPhosphatase2A for parms" \ "" call /kinetics/chain/kinetics[23]/PPhosphatase2A/MAPKK-deph/notes LOAD \ "See: Kyriakis et al Nature 358 pp 417-421 1992" \ "Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway." \ "See parent PPhosphatase2A for parms." call /kinetics/chain/kinetics[23]/PPhosphatase2A/craf**-deph/notes LOAD \ "Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of" \ "craf, so this is there to dephosphorylate it. Identity of phosphatase is not" \ "known to me, but it may be PP2A like the rest, so I have made it so." call /kinetics/chain/kinetics[23]/CaM/CaM/notes LOAD \ "There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al)" \ "Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying" \ "it is comparable to CaMK levels. " \ "" call /kinetics/chain/kinetics[23]/CaM/CaM-TR2-bind-Ca/notes LOAD \ "Lets use the fast rate consts here. Since the rates are so different, I am not" \ "sure whether the order is relevant. These correspond to the TR2C fragment." \ "We use the Martin et al rates here, plus the Drabicowski binding consts." \ "All are scaled by 3X to cell temp." \ "kf = 2e-10 kb = 72" \ "Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11." \ "If kb=72, kf = 2e-10 (Exactly the same !)...." call /kinetics/chain/kinetics[23]/CaM/CaM-TR2-Ca2-bind-Ca/notes LOAD \ "K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get" \ "kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10" \ "" call /kinetics/chain/kinetics[23]/CaM/CaM-Ca3-bind-Ca/notes LOAD \ "Use K3 = 21.5 uM here from Stemmer and Klee table 3." \ "kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10" call /kinetics/chain/kinetics[23]/CaM/CaM-TR2-Ca2/notes LOAD \ "This is the intermediate where the TR2 end (the high-affinity end) has" \ "bound the Ca but the TR1 end has not." call /kinetics/chain/kinetics[23]/Ras-act-unphosph-raf/notes LOAD \ "18 May 2003. This reaction is here to" \ "provide basal activity for MAPK as well" \ "as the potential for direct EGF stimulus" \ "without PKC activation." \ "Based on model from FB/fb28c.g: the model" \ "used for MKP-1 turnover. The rates there" \ "were constrained by basal activity values." call /kinetics/doqcsinfo/notes LOAD \ "This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times." \ "In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec." \ " The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper" \ "" complete_loading