//genesis // kkit Version 11 flat dumpfile // Saved on Thu Feb 12 16:38:37 2009 include kkit {argv 1} FASTDT = 2e-06 SIMDT = 0.001 CONTROLDT = 1 PLOTDT = 10 MAXTIME = 1000 TRANSIENT_TIME = 2 VARIABLE_DT_FLAG = 1 DEFAULT_VOL = 1e-15 VERSION = 11.0 setfield /file/modpath value /home2/bhalla/scripts/modules kparms //genesis initdump -version 3 -ignoreorphans 1 simobjdump table input output alloced step_mode stepsize x y z simobjdump xtree path script namemode sizescale simobjdump xcoredraw xmin xmax ymin ymax simobjdump xtext editable simobjdump xgraph xmin xmax ymin ymax overlay simobjdump xplot pixflags script fg ysquish do_slope wy simobjdump group xtree_fg_req xtree_textfg_req plotfield expanded movealone \ link savename file version md5sum mod_save_flag x y z simobjdump geometry size dim shape outside xtree_fg_req xtree_textfg_req x y \ z simobjdump kpool DiffConst CoInit Co n nInit mwt nMin vol slave_enable \ geomname xtree_fg_req xtree_textfg_req x y z simobjdump kreac kf kb notes xtree_fg_req xtree_textfg_req x y z simobjdump kenz CoComplexInit CoComplex nComplexInit nComplex vol k1 k2 k3 \ keepconc usecomplex notes xtree_fg_req xtree_textfg_req link x y z simobjdump stim level1 width1 delay1 level2 width2 delay2 baselevel trig_time \ trig_mode notes xtree_fg_req xtree_textfg_req is_running x y z simobjdump xtab input output alloced step_mode stepsize notes editfunc \ xtree_fg_req xtree_textfg_req baselevel last_x last_y is_running x y z simobjdump kchan perm gmax Vm is_active use_nernst notes xtree_fg_req \ xtree_textfg_req x y z simobjdump transport input output alloced step_mode stepsize dt delay clock \ kf xtree_fg_req xtree_textfg_req x y z simobjdump proto x y z simobjdump text str simobjdump doqcsinfo filename accessname accesstype transcriber developer \ citation species tissue cellcompartment methodology sources \ model_implementation model_validation editfunc simundump geometry /kinetics/geometry[1] 0 1e-15 3 sphere "" white black 0 0 \ 0 simundump geometry /kinetics/geometry 0 1e-15 3 sphere "" white black 0 0 0 simundump text /kinetics/notes 0 "" call /kinetics/notes LOAD \ "" simundump text /kinetics/geometry[1]/notes 0 "" call /kinetics/geometry[1]/notes LOAD \ "" simundump text /kinetics/geometry/notes 0 "" call /kinetics/geometry/notes LOAD \ "" simundump kpool /kinetics/PP2A 0 0 0.15 0.15 90000 90000 0 0 6e+05 0 \ /kinetics/geometry 4 black 24 12 0 simundump text /kinetics/PP2A/notes 0 "Protein Phosphatase" call /kinetics/PP2A/notes LOAD \ "Protein Phosphatase" simundump kenz /kinetics/PP2A/PP2A_4E-BP** 0 0 0 0 0 6e+05 9.4697e-07 4 1 0 0 \ "" red 4 "" 2 1 0 simundump text /kinetics/PP2A/PP2A_4E-BP**/notes 0 "" call /kinetics/PP2A/PP2A_4E-BP**/notes LOAD \ "" simundump kenz /kinetics/PP2A/PP2A_4E-BP* 0 0 0 0 0 6e+05 9.4697e-07 4 1 0 0 \ "" red 4 "" 4 -6 0 simundump text /kinetics/PP2A/PP2A_4E-BP*/notes 0 "" call /kinetics/PP2A/PP2A_4E-BP*/notes LOAD \ "" simundump kenz /kinetics/PP2A/PP2A_4E-BP 0 0 0 0 0 6e+05 9.4694e-07 4 1 0 0 \ "" red 62 "" 0 8 0 simundump text /kinetics/PP2A/PP2A_4E-BP/notes 0 "" call /kinetics/PP2A/PP2A_4E-BP/notes LOAD \ "" simundump kenz /kinetics/PP2A/PP2A_4EBP 0 0 0 0 0 6e+05 9.4694e-07 4 1 0 0 "" \ red 62 "" 0 4 0 simundump text /kinetics/PP2A/PP2A_4EBP/notes 0 "" call /kinetics/PP2A/PP2A_4EBP/notes LOAD \ "" simundump kpool /kinetics/eIF4E 0 0 0 0 0 0 0 0 5.9999e+05 0 \ /kinetics/geometry 42 black -2 12 0 simundump text /kinetics/eIF4E/notes 0 "" call /kinetics/eIF4E/notes LOAD \ "" simundump kpool /kinetics/Rheb-GTP 0 0 1 1 6e+05 6e+05 0 0 6e+05 0 \ /kinetics/geometry 28 black 26 18 0 simundump text /kinetics/Rheb-GTP/notes 0 "" call /kinetics/Rheb-GTP/notes LOAD \ "" simundump group /kinetics/mTOR_model 0 8 black x 0 0 "" mTOR_model \ defaultfile.g 0 cb4f9df2959ba465dbdd4a6b7a857a4c 0 20 9 0 simundump text /kinetics/mTOR_model/notes 0 "" call /kinetics/mTOR_model/notes LOAD \ "" simundump kreac /kinetics/mTOR_model/Rheb-GTP_bind_TORclx 0 1e-05 3 "" white \ 8 26 4 0 simundump text /kinetics/mTOR_model/Rheb-GTP_bind_TORclx/notes 0 "" call /kinetics/mTOR_model/Rheb-GTP_bind_TORclx/notes LOAD \ "" simundump kpool /kinetics/mTOR_model/TOR-clx 0 0 0.6 0.6 3.6e+05 3.6e+05 0 0 \ 6e+05 0 /kinetics/geometry 25 8 19 -7 0 simundump text /kinetics/mTOR_model/TOR-clx/notes 0 "" call /kinetics/mTOR_model/TOR-clx/notes LOAD \ "" simundump kpool /kinetics/TOR_Rheb-GTP_clx 0 0 0 0 0 0 0 0 6e+05 0 \ /kinetics/geometry 44 black 25 -8 0 simundump text /kinetics/TOR_Rheb-GTP_clx/notes 0 "" call /kinetics/TOR_Rheb-GTP_clx/notes LOAD \ "" simundump kenz /kinetics/TOR_Rheb-GTP_clx/TOR_4E-BP_phospho 0 0 0 0 0 6e+05 \ 4.6296e-06 4 1 0 0 "" red 44 "" 14 1 0 simundump text /kinetics/TOR_Rheb-GTP_clx/TOR_4E-BP_phospho/notes 0 "" call /kinetics/TOR_Rheb-GTP_clx/TOR_4E-BP_phospho/notes LOAD \ "" simundump kenz /kinetics/TOR_Rheb-GTP_clx/TOR_4E-BP* 0 0 0 0 0 6e+05 \ 4.6296e-06 4 1 0 0 "" red 44 "" 11 -9 0 simundump text /kinetics/TOR_Rheb-GTP_clx/TOR_4E-BP*/notes 0 "" call /kinetics/TOR_Rheb-GTP_clx/TOR_4E-BP*/notes LOAD \ "" simundump group /kinetics/4E-BP_mod 0 white black x 0 0 "" 4E-BP_mod \ defaultfile.g 0 0 0 20 21 0 simundump text /kinetics/4E-BP_mod/notes 0 "" call /kinetics/4E-BP_mod/notes LOAD \ "" simundump kreac /kinetics/4E-BP_mod/eIF4E_bind_BP2 0 8.3333e-05 0.15 "" white \ white 2 -3 0 simundump text /kinetics/4E-BP_mod/eIF4E_bind_BP2/notes 0 "" call /kinetics/4E-BP_mod/eIF4E_bind_BP2/notes LOAD \ "" simundump kreac /kinetics/4E-BP_mod/eIF4E-BP2_disso 0 4 1.6667e-06 "" white \ white 0 -2 0 simundump text /kinetics/4E-BP_mod/eIF4E-BP2_disso/notes 0 "" call /kinetics/4E-BP_mod/eIF4E-BP2_disso/notes LOAD \ "" simundump kpool /kinetics/4E-BP_mod/4E-BP 0 0 0 0 0 0 0 0 6e+05 0 \ /kinetics/geometry 47 white 5 -3 0 simundump text /kinetics/4E-BP_mod/4E-BP/notes 0 "" call /kinetics/4E-BP_mod/4E-BP/notes LOAD \ "" simundump kpool /kinetics/4E-BP_mod/4E-BP_thr37_46_s65 0 0 0 0 0 0 0 0 6e+05 \ 0 /kinetics/geometry 59 white 5 2 0 simundump text /kinetics/4E-BP_mod/4E-BP_thr37_46_s65/notes 0 "" call /kinetics/4E-BP_mod/4E-BP_thr37_46_s65/notes LOAD \ "" simundump kpool /kinetics/4E-BP_mod/eIF4E-BP 0 0 0.2 0.2 1.2e+05 1.2e+05 0 0 \ 6e+05 0 /kinetics/geometry 52 white 3 4 0 simundump text /kinetics/4E-BP_mod/eIF4E-BP/notes 0 "" call /kinetics/4E-BP_mod/eIF4E-BP/notes LOAD \ "" simundump kpool /kinetics/4E-BP_mod/eIF4E-BP_thr37_46 0 0 0 0 0 0 0 0 6e+05 0 \ /kinetics/geometry 56 white 5 10 0 simundump text /kinetics/4E-BP_mod/eIF4E-BP_thr37_46/notes 0 "" call /kinetics/4E-BP_mod/eIF4E-BP_thr37_46/notes LOAD \ "" simundump kpool /kinetics/4E-BP_mod/eIF4E_4E-BP_t37_46_s65 0 0 0 0 0 0 0 0 \ 6e+05 0 /kinetics/geometry 39 white 5 14 0 simundump text /kinetics/4E-BP_mod/eIF4E_4E-BP_t37_46_s65/notes 0 "" call /kinetics/4E-BP_mod/eIF4E_4E-BP_t37_46_s65/notes LOAD \ "" simundump kpool /kinetics/4E-BP_tot 0 0 0 0 0 0 0 0 6e+05 0 \ /kinetics/geometry[1] 60 black 5 18 0 simundump text /kinetics/4E-BP_tot/notes 0 "" call /kinetics/4E-BP_tot/notes LOAD \ "" simundump kreac /kinetics/eIF4F_clx 0 5.0001e-05 0.1 "" white black -2 21 0 simundump text /kinetics/eIF4F_clx/notes 0 "" call /kinetics/eIF4F_clx/notes LOAD \ "" simundump kpool /kinetics/eIF4G-A_clx 0 0 0 0 0 0 0 0 5.9999e+05 0 \ /kinetics/geometry cyan black 7 15 0 simundump text /kinetics/eIF4G-A_clx/notes 0 "" call /kinetics/eIF4G-A_clx/notes LOAD \ "" simundump kreac /kinetics/eIF4G_A_clx 0 5.0001e-07 1 "" white black 11 19 0 simundump text /kinetics/eIF4G_A_clx/notes 0 "" call /kinetics/eIF4G_A_clx/notes LOAD \ "" simundump kpool /kinetics/eIF4A 0 0 0.2 0.2 1.2e+05 1.2e+05 0 0 5.9999e+05 0 \ /kinetics/geometry pink black 12 26 0 simundump text /kinetics/eIF4A/notes 0 "" call /kinetics/eIF4A/notes LOAD \ "" simundump kpool /kinetics/eIF4G 0 0 0.040001 0.040001 24000 24000 0 0 \ 5.9999e+05 0 /kinetics/geometry 21 black 13 25 0 simundump text /kinetics/eIF4G/notes 0 "" call /kinetics/eIF4G/notes LOAD \ "" simundump kpool /kinetics/eIF4F 0 0 0 0 0 0 0 0 5.9999e+05 0 \ /kinetics/geometry 6 black 15 9 0 simundump text /kinetics/eIF4F/notes 0 "" call /kinetics/eIF4F/notes LOAD \ "" simundump kpool /kinetics/mRNA 0 0 0.08 0.08 47999 47999 0 0 5.9999e+05 0 \ /kinetics/geometry 60 black 20 14 0 simundump text /kinetics/mRNA/notes 0 "" call /kinetics/mRNA/notes LOAD \ "" simundump kreac /kinetics/eIF4F_mRNA_clx 0 3.3334e-07 0.077 "" white black 19 \ 6 0 simundump text /kinetics/eIF4F_mRNA_clx/notes 0 "" call /kinetics/eIF4F_mRNA_clx/notes LOAD \ "" simundump kpool /kinetics/eIF4F-mRNA_clx 0 0 0 0 0 0 0 0 6e+05 0 \ /kinetics/geometry 59 black 26 6 0 simundump text /kinetics/eIF4F-mRNA_clx/notes 0 "" call /kinetics/eIF4F-mRNA_clx/notes LOAD \ "" simundump kpool /kinetics/MAPK* 1 0 0 0 0 0 0 0 6e+05 0 /kinetics/geometry \ orange yellow 26 12 0 simundump text /kinetics/MAPK*/notes 0 "" call /kinetics/MAPK*/notes LOAD \ "" simundump kenz /kinetics/MAPK*/MAPK_4E-BP** 0 0 0 0 0 6e+05 7.4488e-08 0.64 \ 0.16 0 0 "" red orange "" 12 -2 0 simundump text /kinetics/MAPK*/MAPK_4E-BP**/notes 0 "" call /kinetics/MAPK*/MAPK_4E-BP**/notes LOAD \ "" simundump kenz /kinetics/MAPK*/MAPK_4E-BP_phospho 0 0 0 0 0 6e+05 7.4488e-08 \ 0.64 0.16 0 0 "" red 47 "" 4 8 0 simundump text /kinetics/MAPK*/MAPK_4E-BP_phospho/notes 0 "" call /kinetics/MAPK*/MAPK_4E-BP_phospho/notes LOAD \ "" simundump kreac /kinetics/eIF4E-BP_disso 0 1 1.6667e-07 "" white black 6 6 0 simundump text /kinetics/eIF4E-BP_disso/notes 0 "" call /kinetics/eIF4E-BP_disso/notes LOAD \ "" simundump kpool /kinetics/4E-BP_t37_46 0 0 0 0 0 0 0 0 6e+05 0 \ /kinetics/geometry 60 black 6 -3 0 simundump text /kinetics/4E-BP_t37_46/notes 0 "" call /kinetics/4E-BP_t37_46/notes LOAD \ "" simundump doqcsinfo /kinetics/doqcsinfo 0 4EBP.g 4EBP Network \ "Pragati Jain, NCBS" "Pragati Jain, NCBS" "citation here" \ "General Mammalian" "E.coli Expression" "Surface, Cytosol" \ "Quantitative match to experiments, Qualitative" "Jain P, and Bhalla, U.S. PLoS Comput Biol. 2009 Feb;5(2). ( Peer-reviewed publication )" \ "Exact GENESIS implementation" "Approximates original data " show_dumpdb simundump text /kinetics/doqcsinfo/notes 0 \ "Rheb-GTP activates mTOR, again with regulation by MAPK, leading to formation of the\n eIF4F-mRNA complex." call /kinetics/doqcsinfo/notes LOAD \ "Rheb-GTP activates mTOR, again with regulation by MAPK, leading to formation of the" \ " eIF4F-mRNA complex." simundump xgraph /graphs/conc1 0 0 10070 0 0.88766 0 simundump xgraph /graphs/conc2 0 0 7890 0 0.47175 0 simundump xplot /graphs/conc1/MAPK*.Co 3 524288 \ "delete_plot.w ; edit_plot.D " orange 0 0 1 simundump xplot /graphs/conc1/eIF4E.Co 3 524288 \ "delete_plot.w ; edit_plot.D " 42 0 0 1 simundump xplot /graphs/conc1/eIF4F-mRNA_clx.Co 3 524288 \ "delete_plot.w ; edit_plot.D " 59 0 0 1 simundump xplot /graphs/conc1/eIF4F.Co 3 524288 \ "delete_plot.w ; edit_plot.D " 6 0 0 1 simundump xplot /graphs/conc1/eIF4G-A_clx.Co 3 524288 \ "delete_plot.w ; edit_plot.D " cyan 0 0 1 simundump xplot /graphs/conc2/4E-BP_tot.Co 3 524288 \ "delete_plot.w ; edit_plot.D " 60 0 0 1 simundump xgraph /moregraphs/conc3 0 0 12000 0 0.25 0 simundump xgraph /moregraphs/conc4 0 0 12000 0 0.71395 0 simundump xplot /moregraphs/conc4/TOR_Rheb-GTP_clx.Co 3 524288 \ "delete_plot.w ; edit_plot.D " 44 0 0 1 simundump xplot /moregraphs/conc4/Rheb-GTP.Co 3 524288 \ "delete_plot.w ; edit_plot.D " 28 0 0 1 simundump xplot /moregraphs/conc4/eIF4E-BP2.Co 3 524288 \ "delete_plot.w ; edit_plot.D " 52 0 0 1 simundump xplot /moregraphs/conc4/eIF4E-BP2_thr37_46.Co 3 524288 \ "delete_plot.w ; edit_plot.D " 56 0 0 1 simundump xplot /moregraphs/conc4/eIF4E_4E-BP2_t37_46_s65.Co 3 524288 \ "delete_plot.w ; edit_plot.D " 39 0 0 1 simundump xplot /moregraphs/conc4/4E-BP2_thr37_46_s65.Co 3 524288 \ "delete_plot.w ; edit_plot.D " 59 0 0 1 simundump xplot /moregraphs/conc4/4E-BP2_t37_46.Co 3 524288 \ "delete_plot.w ; edit_plot.D " 60 0 0 1 simundump xcoredraw /edit/draw 0 -4 28 -11 28 simundump xtree /edit/draw/tree 0 \ /kinetics/#[],/kinetics/#[]/#[],/kinetics/#[]/#[]/#[][TYPE!=proto],/kinetics/#[]/#[]/#[][TYPE!=linkinfo]/##[] \ "edit_elm.D ; drag_from_edit.w " auto 0.6 simundump xtext /file/notes 0 1 xtextload /file/notes \ "" \ "" \ " " addmsg /kinetics/PP2A/PP2A_4EBP /kinetics/PP2A REAC eA B addmsg /kinetics/PP2A/PP2A_4E-BP /kinetics/PP2A REAC eA B addmsg /kinetics/PP2A/PP2A_4E-BP** /kinetics/PP2A REAC eA B addmsg /kinetics/PP2A/PP2A_4E-BP* /kinetics/PP2A REAC eA B addmsg /kinetics/PP2A /kinetics/PP2A/PP2A_4E-BP** ENZYME n addmsg /kinetics/4E-BP_mod/4E-BP_thr37_46_s65 /kinetics/PP2A/PP2A_4E-BP** SUBSTRATE n addmsg /kinetics/PP2A /kinetics/PP2A/PP2A_4E-BP* ENZYME n addmsg /kinetics/4E-BP_t37_46 /kinetics/PP2A/PP2A_4E-BP* SUBSTRATE n addmsg /kinetics/PP2A /kinetics/PP2A/PP2A_4E-BP ENZYME n addmsg /kinetics/4E-BP_mod/eIF4E_4E-BP_t37_46_s65 /kinetics/PP2A/PP2A_4E-BP SUBSTRATE n addmsg /kinetics/PP2A /kinetics/PP2A/PP2A_4EBP ENZYME n addmsg /kinetics/4E-BP_mod/eIF4E-BP_thr37_46 /kinetics/PP2A/PP2A_4EBP SUBSTRATE n addmsg /kinetics/4E-BP_mod/eIF4E-BP2_disso /kinetics/eIF4E REAC B A addmsg /kinetics/eIF4F_clx /kinetics/eIF4E REAC A B addmsg /kinetics/eIF4E-BP_disso /kinetics/eIF4E REAC B A addmsg /kinetics/4E-BP_mod/eIF4E_bind_BP2 /kinetics/eIF4E REAC A B addmsg /kinetics/mTOR_model/Rheb-GTP_bind_TORclx /kinetics/Rheb-GTP REAC A B addmsg /kinetics/Rheb-GTP /kinetics/mTOR_model/Rheb-GTP_bind_TORclx SUBSTRATE n addmsg /kinetics/mTOR_model/TOR-clx /kinetics/mTOR_model/Rheb-GTP_bind_TORclx SUBSTRATE n addmsg /kinetics/TOR_Rheb-GTP_clx /kinetics/mTOR_model/Rheb-GTP_bind_TORclx PRODUCT n addmsg /kinetics/mTOR_model/Rheb-GTP_bind_TORclx /kinetics/mTOR_model/TOR-clx REAC A B addmsg /kinetics/mTOR_model/Rheb-GTP_bind_TORclx /kinetics/TOR_Rheb-GTP_clx REAC B A addmsg /kinetics/TOR_Rheb-GTP_clx/TOR_4E-BP_phospho /kinetics/TOR_Rheb-GTP_clx REAC eA B addmsg /kinetics/TOR_Rheb-GTP_clx/TOR_4E-BP* /kinetics/TOR_Rheb-GTP_clx REAC eA B addmsg /kinetics/TOR_Rheb-GTP_clx /kinetics/TOR_Rheb-GTP_clx/TOR_4E-BP_phospho ENZYME n addmsg /kinetics/4E-BP_mod/eIF4E-BP /kinetics/TOR_Rheb-GTP_clx/TOR_4E-BP_phospho SUBSTRATE n addmsg /kinetics/TOR_Rheb-GTP_clx /kinetics/TOR_Rheb-GTP_clx/TOR_4E-BP* ENZYME n addmsg /kinetics/4E-BP_mod/4E-BP /kinetics/TOR_Rheb-GTP_clx/TOR_4E-BP* SUBSTRATE n addmsg /kinetics/4E-BP_mod/4E-BP /kinetics/4E-BP_mod/eIF4E_bind_BP2 SUBSTRATE n addmsg /kinetics/eIF4E /kinetics/4E-BP_mod/eIF4E_bind_BP2 SUBSTRATE n addmsg /kinetics/4E-BP_mod/eIF4E-BP /kinetics/4E-BP_mod/eIF4E_bind_BP2 PRODUCT n addmsg /kinetics/eIF4E /kinetics/4E-BP_mod/eIF4E-BP2_disso PRODUCT n addmsg /kinetics/4E-BP_mod/eIF4E_4E-BP_t37_46_s65 /kinetics/4E-BP_mod/eIF4E-BP2_disso SUBSTRATE n addmsg /kinetics/4E-BP_mod/4E-BP_thr37_46_s65 /kinetics/4E-BP_mod/eIF4E-BP2_disso PRODUCT n addmsg /kinetics/TOR_Rheb-GTP_clx/TOR_4E-BP* /kinetics/4E-BP_mod/4E-BP REAC sA B addmsg /kinetics/PP2A/PP2A_4E-BP* /kinetics/4E-BP_mod/4E-BP MM_PRD pA addmsg /kinetics/4E-BP_mod/eIF4E_bind_BP2 /kinetics/4E-BP_mod/4E-BP REAC A B addmsg /kinetics/4E-BP_mod/eIF4E-BP2_disso /kinetics/4E-BP_mod/4E-BP_thr37_46_s65 REAC B A addmsg /kinetics/MAPK*/MAPK_4E-BP** /kinetics/4E-BP_mod/4E-BP_thr37_46_s65 MM_PRD pA addmsg /kinetics/PP2A/PP2A_4E-BP** /kinetics/4E-BP_mod/4E-BP_thr37_46_s65 REAC sA B addmsg /kinetics/TOR_Rheb-GTP_clx/TOR_4E-BP_phospho /kinetics/4E-BP_mod/eIF4E-BP REAC sA B addmsg /kinetics/PP2A/PP2A_4EBP /kinetics/4E-BP_mod/eIF4E-BP MM_PRD pA addmsg /kinetics/4E-BP_mod/eIF4E_bind_BP2 /kinetics/4E-BP_mod/eIF4E-BP REAC B A addmsg /kinetics/TOR_Rheb-GTP_clx/TOR_4E-BP_phospho /kinetics/4E-BP_mod/eIF4E-BP_thr37_46 MM_PRD pA addmsg /kinetics/PP2A/PP2A_4EBP /kinetics/4E-BP_mod/eIF4E-BP_thr37_46 REAC sA B addmsg /kinetics/MAPK*/MAPK_4E-BP_phospho /kinetics/4E-BP_mod/eIF4E-BP_thr37_46 REAC sA B addmsg /kinetics/PP2A/PP2A_4E-BP /kinetics/4E-BP_mod/eIF4E-BP_thr37_46 MM_PRD pA addmsg /kinetics/eIF4E-BP_disso /kinetics/4E-BP_mod/eIF4E-BP_thr37_46 REAC A B addmsg /kinetics/MAPK*/MAPK_4E-BP_phospho /kinetics/4E-BP_mod/eIF4E_4E-BP_t37_46_s65 MM_PRD pA addmsg /kinetics/PP2A/PP2A_4E-BP /kinetics/4E-BP_mod/eIF4E_4E-BP_t37_46_s65 REAC sA B addmsg /kinetics/4E-BP_mod/eIF4E-BP2_disso /kinetics/4E-BP_mod/eIF4E_4E-BP_t37_46_s65 REAC A B addmsg /kinetics/4E-BP_mod/eIF4E-BP_thr37_46 /kinetics/4E-BP_tot SUMTOTAL n nInit addmsg /kinetics/4E-BP_mod/eIF4E_4E-BP_t37_46_s65 /kinetics/4E-BP_tot SUMTOTAL n nInit addmsg /kinetics/4E-BP_mod/4E-BP_thr37_46_s65 /kinetics/4E-BP_tot SUMTOTAL n nInit addmsg /kinetics/4E-BP_t37_46 /kinetics/4E-BP_tot SUMTOTAL n nInit addmsg /kinetics/eIF4G-A_clx /kinetics/eIF4F_clx SUBSTRATE n addmsg /kinetics/eIF4F /kinetics/eIF4F_clx PRODUCT n addmsg /kinetics/eIF4E /kinetics/eIF4F_clx SUBSTRATE n addmsg /kinetics/eIF4F_clx /kinetics/eIF4G-A_clx REAC A B addmsg /kinetics/eIF4G_A_clx /kinetics/eIF4G-A_clx REAC B A addmsg /kinetics/eIF4A /kinetics/eIF4G_A_clx SUBSTRATE n addmsg /kinetics/eIF4G /kinetics/eIF4G_A_clx SUBSTRATE n addmsg /kinetics/eIF4G-A_clx /kinetics/eIF4G_A_clx PRODUCT n addmsg /kinetics/eIF4G_A_clx /kinetics/eIF4A REAC A B addmsg /kinetics/eIF4G_A_clx /kinetics/eIF4G REAC A B addmsg /kinetics/eIF4F_clx /kinetics/eIF4F REAC B A addmsg /kinetics/eIF4F_mRNA_clx /kinetics/eIF4F REAC A B addmsg /kinetics/eIF4F_mRNA_clx /kinetics/mRNA REAC A B addmsg /kinetics/mRNA /kinetics/eIF4F_mRNA_clx SUBSTRATE n addmsg /kinetics/eIF4F-mRNA_clx /kinetics/eIF4F_mRNA_clx PRODUCT n addmsg /kinetics/eIF4F /kinetics/eIF4F_mRNA_clx SUBSTRATE n addmsg /kinetics/eIF4F_mRNA_clx /kinetics/eIF4F-mRNA_clx REAC B A addmsg /kinetics/MAPK*/MAPK_4E-BP_phospho /kinetics/MAPK* REAC eA B addmsg /kinetics/MAPK*/MAPK_4E-BP** /kinetics/MAPK* REAC eA B addmsg /kinetics/MAPK* /kinetics/MAPK*/MAPK_4E-BP** ENZYME n addmsg /kinetics/4E-BP_t37_46 /kinetics/MAPK*/MAPK_4E-BP** SUBSTRATE n addmsg /kinetics/MAPK* /kinetics/MAPK*/MAPK_4E-BP_phospho ENZYME n addmsg /kinetics/4E-BP_mod/eIF4E-BP_thr37_46 /kinetics/MAPK*/MAPK_4E-BP_phospho SUBSTRATE n addmsg /kinetics/4E-BP_mod/eIF4E-BP_thr37_46 /kinetics/eIF4E-BP_disso SUBSTRATE n addmsg /kinetics/4E-BP_t37_46 /kinetics/eIF4E-BP_disso PRODUCT n addmsg /kinetics/eIF4E /kinetics/eIF4E-BP_disso PRODUCT n addmsg /kinetics/eIF4E-BP_disso /kinetics/4E-BP_t37_46 REAC B A addmsg /kinetics/MAPK*/MAPK_4E-BP** /kinetics/4E-BP_t37_46 REAC sA B addmsg /kinetics/PP2A/PP2A_4E-BP** /kinetics/4E-BP_t37_46 MM_PRD pA addmsg /kinetics/TOR_Rheb-GTP_clx/TOR_4E-BP* /kinetics/4E-BP_t37_46 MM_PRD pA addmsg /kinetics/PP2A/PP2A_4E-BP* /kinetics/4E-BP_t37_46 REAC sA B addmsg /kinetics/MAPK* /graphs/conc1/MAPK*.Co PLOT Co *MAPK*.Co *orange addmsg /kinetics/eIF4E /graphs/conc1/eIF4E.Co PLOT Co *eIF4E.Co *42 addmsg /kinetics/eIF4F-mRNA_clx /graphs/conc1/eIF4F-mRNA_clx.Co PLOT Co *eIF4F-mRNA_clx.Co *59 addmsg /kinetics/eIF4F /graphs/conc1/eIF4F.Co PLOT Co *eIF4F.Co *6 addmsg /kinetics/eIF4G-A_clx /graphs/conc1/eIF4G-A_clx.Co PLOT Co *eIF4G-A_clx.Co *cyan addmsg /kinetics/4E-BP_tot /graphs/conc2/4E-BP_tot.Co PLOT Co *4E-BP_tot.Co *60 addmsg /kinetics/TOR_Rheb-GTP_clx /moregraphs/conc4/TOR_Rheb-GTP_clx.Co PLOT Co *TOR_Rheb-GTP_clx.Co *44 addmsg /kinetics/Rheb-GTP /moregraphs/conc4/Rheb-GTP.Co PLOT Co *Rheb-GTP.Co *28 addmsg /kinetics/4E-BP_mod/eIF4E-BP /moregraphs/conc4/eIF4E-BP2.Co PLOT Co *eIF4E-BP2.Co *52 addmsg /kinetics/4E-BP_mod/eIF4E-BP_thr37_46 /moregraphs/conc4/eIF4E-BP2_thr37_46.Co PLOT Co *eIF4E-BP2_thr37_46.Co *56 addmsg /kinetics/4E-BP_mod/eIF4E_4E-BP_t37_46_s65 /moregraphs/conc4/eIF4E_4E-BP2_t37_46_s65.Co PLOT Co *eIF4E_4E-BP2_t37_46_s65.Co *39 addmsg /kinetics/4E-BP_mod/4E-BP_thr37_46_s65 /moregraphs/conc4/4E-BP2_thr37_46_s65.Co PLOT Co *4E-BP2_thr37_46_s65.Co *59 addmsg /kinetics/4E-BP_t37_46 /moregraphs/conc4/4E-BP2_t37_46.Co PLOT Co *4E-BP2_t37_46.Co *60 enddump // End of dump call /kinetics/PP2A/notes LOAD \ "Protein Phosphatase" call /kinetics/doqcsinfo/notes LOAD \ "Rheb-GTP activates mTOR, again with regulation by MAPK, leading to formation of the" \ " eIF4F-mRNA complex." 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