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"Connected to" List for CamKII

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Statistics

CamKII participated as Model  Pathway  Molecule  Sum total of  Enzyme  Substrate of an enzyme  Product of an enzyme  Reaction  Substrate in reaction  Product in a reaction 
No. of occurrences27342478218120920854116112

CamKII found in these Models

Model in which CamKII acting as a molecule or reaction or enzyme are listed here.
 Name /
Accession No.
Accession
Type /
Entry Date
Model TypeAccession StatisticsCamKII StatisticSpecies /
Tissue
Cell Compartment /
Source
Methodology /
Model_Implementation
1fig3_CaMKII/
Accession No. : 2
Network /
2001-11-07 00:00:00
ChemicalMolecule = 59
Enzyme   = 29
Reaction  = 29
Molecule = 9
Enzyme   = 4
Reaction  = 1
Generic mammalian /
Neuronal
Synapse /
Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )
Quantitative match to experiments, Qualitative /
Exact GENESIS implementation
    This is the model file for figure 3 from Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It is a model of the Ca activation of CaMKII and other CaM-activated enzymes. It includes the regulatory phosphatases PP1 and PP2B (Calcineurin) acting on CaMKII and also includes CaM-activated adenylyl cyclase and PKA in the synapse.
Demonstration script files for generating the figures in the paper, including figure 3, are available here.
2fig4_synapse/
Accession No. : 3
Network /
2001-11-07 00:00:00
ChemicalMolecule = 122
Enzyme   = 56
Reaction  = 70
Molecule = 9
Enzyme   = 4
Reaction  = 1
Generic mammalian /
Neuronal
Synapse /
Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )
Quantitative match to experiments, Qualitative, Hypothetical /
Exact GENESIS implementation
    This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper.
Demonstration script files for generating the figures in the paper, including figure 4, are available here.
3
  • Synaptic_
    Network
    /
    Accession No. : 16
  • Network /
    2001-12-12 00:00:00
    ChemicalMolecule = 148
    Enzyme   = 63
    Reaction  = 84
    Molecule = 8
    Enzyme   = 4
    Reaction  = 1
    Generic mammalian /
    Neuronal
    Synapse /
    Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )
    Quantitative match to experiments, Qualitative /
    Exact GENESIS implementation
        This model is an annotated version of the synaptic signaling network.
    The primary reference is Bhalla US and Iyengar R. Science (1999) 283(5400):381-7 but several of the model pathways have been updated.
    Bhalla US Biophys J. 2002 Aug;83(2):740-52
    Bhalla US J Comput Neurosci. 2002 Jul-Aug;13(1):49-62
    4
  • NOS_Phosph_
    regulation
    /
    Accession No. : 20
  • Pathway /
    2001-12-25 00:00:00
    ChemicalMolecule = 10
    Enzyme   = 4
    Reaction  = 2
    Molecule = 1
    Enzyme   = 1
    Reaction  = 0
    rat; Mammalian /
    Brain - Neuronal; expressed in E.coli
    Cytosol /
    In-house
    Quantitative match to experiments, Qualitative /
    Exact GENESIS implementation
        This model features the phosphorylation of rat brain neuronal NOS expressed in E. coli or Sf9 cells, which leads to a decrease in Vmax of the phosphorylated enzyme, with little change of both the Km for L-arginine and Kact for CaM. This is based on Hayashi Y. et al. J Biol Chem. (1999) 274(29):20597-602. They report of phosphorylatin being carried out by CaM kinases I alpha, II alpha and IV. The rates used have been obtained from their paper and from other reported experimental data.
    5
  • NonOsc_Ca_
    IP3metabolism
    /
    Accession No. : 23
  • Network /
    2002-01-07 00:00:00
    ChemicalMolecule = 134
    Enzyme   = 48
    Reaction  = 81
    Molecule = 8
    Enzyme   = 8
    Reaction  = 1
    Generic mammalian /
    Brain - Neuronal
    Cytosol /
    Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication )
    Quantitative match to experiments, Qualitative /
    Approximate implementation
        This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. The calcium response is non-oscillatory. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.
    Statistics To see the complete set of data click here.To see the Next set of entry click here

    CamKII found in these Pathways

    Pathway in which CamKII acting as a molecule or reaction or enzyme are listed here.
     Pathway
    Name
    Accession
    Name
    Model Type /
    Accession Type
    Pathway StatisticsCamKII StatisticsSource /
    Entry
    Date
    1CaMKII

    Pathway No. : 235
  • AMPAR_traff_
    model0

    Accession No. : 59
  • Chemical /
    Network
    Molecule = 25
    Enzyme   = 24
    Reaction  = 10
    Molecule = 21
    Enzyme   = 22
    Reaction  = 5
    Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication ) /
    2005-07-19 00:00:00
       Related Pathway :
    132680106121145159174202216245258264272282322339357
        This is model 0 from Hayer and Bhalla, PLoS Comput Biol 2005. It has a bistable model of AMPAR traffick, plus a non-bistable model of CaMKII. This differs from the reference model (model 1) in that model0 lacks degradation and turno ver reactions for AMPAR.
    2CaMKII

    Pathway No. : 245
  • AMPAR_traff_
    model1

    Accession No. : 60
  • Chemical /
    Network
    Molecule = 25
    Enzyme   = 24
    Reaction  = 10
    Molecule = 21
    Enzyme   = 22
    Reaction  = 5
    Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication ) /
    2005-07-19 00:00:00
       Related Pathway :
    132680106121145159174202216235258264272282322339357
        This is the basic model of AMPAR trafficking bistability. It is based on Hayer and Bhalla, PLoS Comput. Biol. 2005. It includes the degradation and turnover of AMPARs. The CaMKII portion of the model is not bistable.
    3
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Chemical /
    Network
    Molecule = 51
    Enzyme   = 148
    Reaction  = 16
    Molecule = 14
    Enzyme   = 19
    Reaction  = 4
    Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication ) /
    2005-07-19 00:00:00
       Related Pathway :
        This is a model of tight coupling between the AMPAR trafficking bistability, and the CaMKII autophosphorylation bistability. In this model, the CaMKII activity is self sustaining only when AMPAR is turned on. Further, CaMKII turns on when AMPAR is turned on.
    4CaMKII_PSD

    Pathway No. : 292
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • Chemical /
    Network
    Molecule = 14
    Enzyme   = 22
    Reaction  = 8
    Molecule = 11
    Enzyme   = 19
    Reaction  = 4
    Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication ) /
    2005-07-21 00:00:00
       Related Pathway :
        This is a model of weak coupling between the AMPAR traffikcing bistability, and the CaMKII autophosphorylation bistability. In this model, there are three stable states: Both off, AMPAR on, or both on. The fourth possible state: CaMKII on but AMPAR off, is not truly stable, since over the course of hours the AMPAR also turns on.
    5
  • Shared_Object_
    CaMKIII

    Pathway No. : 1093
  • CaMKIII

    Accession No. : 90
    Chemical /
    Network
    Molecule = 15
    Enzyme   = 5
    Reaction  = 3
    Molecule = 4
    Enzyme   = 4
    Reaction  = 2
    Jain P, and Bhalla, U.S. PLoS Comput Biol. 2009 Feb;5(2). ( Peer-reviewed publication ) /
    2009-02-12 00:00:00
       Related Pathway :
        CaMKIII is activated by Ca2+ and inactivated by S6K. Since CaMKIII inhibits eEF2, the net effect of Ca2+ on elongation is inhibitory and of S6K is excitatory
    Statistics To see the complete set of data click here.To see the Next set of entry click here

    CamKII acting as a Molecule

     NameAccession Name
    Accession No.
    Pathway Name
    Pathway No.
    Initial Conc.(uM)Volume(fL)Buffered
    1aCaMKIIbcm
    Accession No. 107
    CaMKII_g

    Pathway No. 1138
    0-No
    2aCaMKIII
  • syn_prot_
    composite

    Accession No. 109
  • CaMKIII_g

    Pathway No. 1145
    0-No
    3aCaMKIIIaut6
    Accession No. 110
    CaMKIII_g

    Pathway No. 1151
    0-No
    4aCaMKIIIsyn_CaMKIII
    Accession No. 114
    CaMKIII_g

    Pathway No. 1159
    0-No
    5actCaMKII-PSD
  • AMPAR_traff_
    model0

    Accession No. 59
  • CaMKII

    Pathway No. 235
    20.01No
    Statistics To see the complete set of data click here.To see the Next set of entry click here

    CamKII acting as Summed Molecule

     Accession Name
    Accession No.
    Pathway Name
    Pathway No.
    TargetInput
    1fig3_CaMKII
    Accession No. 2
  • Shared_Object_
    fig3_CaMKII

    Pathway No. 12
  • tot_
    CaMKII-active
  • tot_CaM_CaMKII
  • tot_autonomous_
    CaMKII

  • 2fig3_CaMKII
    Accession No. 2
    CaMKII
    Pathway No. 13
    tot_CaM_CaMKII
    CaMKII-CaM
  • CaMKII-thr286*-C
    aM

  • 3fig3_CaMKII
    Accession No. 2
    CaMKII
    Pathway No. 13
  • tot_autonomous_
    CaMKII
  • CaMKII-thr286
    CaMKII***
    4fig4_synapse
    Accession No. 3
  • Shared_Object_
    fig4_synapse

    Pathway No. 19
  • CaMKII-act
    tot_CaM_CaMKII
  • tot_autonomous_
    CaMKII

  • 5fig4_synapse
    Accession No. 3
    CaMKII
    Pathway No. 26
    tot_CaM_CaMKII
    CaMKII-CaM
  • CaMKII-thr286*-C
    aM

  • Statistics To see the complete set of data click here.To see the Next set of entry click here

    CamKII acting as an Enzyme

     Enzyme Molecule /
    Enzyme Activity
    Accession Name
    Accession No.
    Pathway Name
    Pathway No.
    Km (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1tot_CaM_CaMKII
      /
    CaM_act_305
    fig3_CaMKII
    Accession No. 2
    CaMKII
    Pathway No. 13
    0.0000027056364explicit E-S complexSubstrate:
    CaMKII-thr286

    Product:
    CaMKII***
    2tot_CaM_CaMKII
      /
    CaM_act_286
    fig3_CaMKII
    Accession No. 2
    CaMKII
    Pathway No. 13
    0.000002705630.54explicit E-S complexSubstrate:
    CaMKII-CaM

    Product:
    CaMKII-thr286*-C
    aM

    3
  • tot_autonomous_
    CaMKII
      /
    auton_305
  • fig3_CaMKII
    Accession No. 2
    CaMKII
    Pathway No. 13
    0.0000041666764explicit E-S complexSubstrate:
    CaMKII-thr286

    Product:
    CaMKII***
    4
  • tot_autonomous_
    CaMKII
      /
    auton_286
  • fig3_CaMKII
    Accession No. 2
    CaMKII
    Pathway No. 13
    0.000004166670.54explicit E-S complexSubstrate:
    CaMKII-CaM

    Product:
    CaMKII-thr286*-C
    aM

    5tot_CaM_CaMKII
      /
    CaM_act_305
    fig4_synapse
    Accession No. 3
    CaMKII
    Pathway No. 26
    0.0000027056364explicit E-S complexSubstrate:
    CaMKII-thr286

    Product:
    CaMKII***
    Statistics To see the complete set of data click here.To see the Next set of entry click here

    CamKII acting as a Subtrate for an Enzyme

     Enzyme Molecule /
    Enzyme Activity
    Accession Name
    Accession No.
    Pathway Name
    Pathway No.
    Km (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1PP1-active  /
    Deph-thr286
    fig3_CaMKII
    Accession No. 2
  • Shared_Object_
    fig3_CaMKII

    Pathway No. 12
  • 5.099070.354explicit E-S complexSubstrate:
  • CaMKII-thr286*-C
    aM


    Product:
    CaMKII-CaM
  • 2PP1-active  /
    Deph-thr305
    fig3_CaMKII
    Accession No. 2
  • Shared_Object_
    fig3_CaMKII

    Pathway No. 12
  • 5.099070.354explicit E-S complexSubstrate:
    CaMKII***

    Product:
    CaMKII-thr286
    3PP1-active  /
    Deph-thr286c
    fig3_CaMKII
    Accession No. 2
  • Shared_Object_
    fig3_CaMKII

    Pathway No. 12
  • 5.099070.354explicit E-S complexSubstrate:
    CaMKII***

    Product:
    CaMK-thr306
    4PP1-active  /
    Deph_thr286b
    fig3_CaMKII
    Accession No. 2
  • Shared_Object_
    fig3_CaMKII

    Pathway No. 12
  • 5.099070.354explicit E-S complexSubstrate:
    CaMKII-thr286

    Product:
    CaMKII
    5tot_CaM_CaMKII  /
    CaM_act_305
    fig3_CaMKII
    Accession No. 2
    CaMKII
    Pathway No. 13
    0.0000027056364explicit E-S complexSubstrate:
    CaMKII-thr286

    Product:
    CaMKII***
    Statistics To see the complete set of data click here.To see the Next set of entry click here

    CamKII acting as a Product for an Enzyme

     Enzyme Molecule /
    Enzyme Activity
    Accession Name
    Accession No.
    Pathway Name
    Pathway No.
    Km (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1PP1-active  /
    Deph-thr286
    fig3_CaMKII
    Accession No. 2
  • Shared_Object_
    fig3_CaMKII

    Pathway No. 12
  • 5.099070.354explicit E-S complexSubstrate:
  • CaMKII-thr286*-C
    aM


    Product:
    CaMKII-CaM
  • 2PP1-active  /
    Deph-thr305
    fig3_CaMKII
    Accession No. 2
  • Shared_Object_
    fig3_CaMKII

    Pathway No. 12
  • 5.099070.354explicit E-S complexSubstrate:
    CaMKII***

    Product:
    CaMKII-thr286
    3PP1-active  /
    Deph-thr306
    fig3_CaMKII
    Accession No. 2
  • Shared_Object_
    fig3_CaMKII

    Pathway No. 12
  • 5.099070.354explicit E-S complexSubstrate:
    CaMK-thr306

    Product:
    CaMKII
    4PP1-active  /
    Deph_thr286b
    fig3_CaMKII
    Accession No. 2
  • Shared_Object_
    fig3_CaMKII

    Pathway No. 12
  • 5.099070.354explicit E-S complexSubstrate:
    CaMKII-thr286

    Product:
    CaMKII
    5tot_CaM_CaMKII  /
    CaM_act_305
    fig3_CaMKII
    Accession No. 2
    CaMKII
    Pathway No. 13
    0.0000027056364explicit E-S complexSubstrate:
    CaMKII-thr286

    Product:
    CaMKII***
    Statistics To see the complete set of data click here.To see the Next set of entry click here

    CamKII acting as a Reaction

    Keq is calculated only for first order reactions. Kd is calculated only for second order reactions. [ nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules]
     NameAccession Name
    Accession No.
    Pathway Name
    Pathway No.
    KfKbKdtauReagents
    1 CaMKII-bind-CaMfig3_CaMKII
    Accession No. 2
    CaMKII
    Pathway No. 13
    49.9998
    uM^-1 s^-1
    5
    s^-1
    Kd(bf) = 0.1(uM)-Substrate:
    CaM-Ca4
    CaMKII

    Product:
    CaMKII-CaM
    2 CaMKII-bind-CaMfig4_synapse
    Accession No. 3
    CaMKII
    Pathway No. 26
    49.9998
    uM^-1 s^-1
    5
    s^-1
    Kd(bf) = 0.1(uM)-Substrate:
    CaM-Ca4
    CaMKII

    Product:
    CaMKII-CaM
    3 CaMKII-bind-CaM
  • Synaptic_
    Network

    Accession No. 16
  • CaMKII
    Pathway No. 80
    49.9998
    uM^-1 s^-1
    5
    s^-1
    Kd(bf) = 0.1(uM)-Substrate:
    CaM-Ca4
    CaMKII

    Product:
    CaMKII-CaM
      This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kd = 0.1 uM. Rate is fast (see Hanson et al Neuron 12 943-956 1994) Hanson and Schulman 1992 AnnRev Biochem 61:559-601 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol.
    4 CaMKII-bind-CaM
  • NonOsc_Ca_
    IP3metabolism

    Accession No. 23
  • CaMKII
    Pathway No. 106
    49.9998
    uM^-1 s^-1
    5
    s^-1
    Kd(bf) = 0.1(uM)-Substrate:
    CaM-Ca4
    CaMKII

    Product:
    CaMKII-CaM
      This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kd = 0.1 uM. Rate is fast (see Hanson et al Neuron 12 943-956 1994) Hanson and Schulman 1992 AnnRev Biochem 61:559-601 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol.
    5 CaMKII-bind-CaM
  • Osc_Ca_
    IP3metabolism

    Accession No. 24
  • CaMKII
    Pathway No. 121
    49.9998
    uM^-1 s^-1
    5
    s^-1
    Kd(bf) = 0.1(uM)-Substrate:
    CaM-Ca4
    CaMKII

    Product:
    CaMKII-CaM
      This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kd = 0.1 uM. Rate is fast (see Hanson et al Neuron 12 943-956 1994) Hanson and Schulman 1992 AnnRev Biochem 61:559-601 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol.
    Statistics To see the complete set of data Click hereTo see the Next set of entry click here

    CamKII acting as a Substrate in a Reaction

    Keq is calculated only for first order reactions. Kd is calculated only for second order reactions. [ nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules]
     NameAccession Name
    Accession No.
    Pathway Name
    Pathway No.
    KfKbKdtauReagents
    1 CaMKII-bind-CaMfig3_CaMKII
    Accession No. 2
    CaMKII
    Pathway No. 13
    49.9998
    uM^-1 s^-1
    5
    s^-1
    Kd(bf) = 0.1(uM)-Substrate:
    CaM-Ca4
    CaMKII

    Product:
    CaMKII-CaM
    2
  • CaMK-thr286-bind
    -CaM
  • fig3_CaMKII
    Accession No. 2
    CaMKII
    Pathway No. 13
    1000.2
    uM^-1 s^-1
    0.1
    s^-1
    Kd(bf) = 0.0001(uM)-Substrate:
    CaMKII-thr286
    CaM-Ca4

    Product:
  • CaMKII-thr286*-C
    aM

  • 3 basal-activityfig3_CaMKII
    Accession No. 2
    CaMKII
    Pathway No. 13
    0.003
    s^-1
    0
    s^-1
    --Substrate:
    CaMKII

    Product:
    CaMKII-thr286
    4 CaMKII-bind-CaMfig4_synapse
    Accession No. 3
    CaMKII
    Pathway No. 26
    49.9998
    uM^-1 s^-1
    5
    s^-1
    Kd(bf) = 0.1(uM)-Substrate:
    CaM-Ca4
    CaMKII

    Product:
    CaMKII-CaM
    5
  • CaMK-thr286-bind
    -CaM
  • fig4_synapse
    Accession No. 3
    CaMKII
    Pathway No. 26
    1000.2
    uM^-1 s^-1
    0.1
    s^-1
    Kd(bf) = 0.0001(uM)-Substrate:
    CaMKII-thr286
    CaM-Ca4

    Product:
  • CaMKII-thr286*-C
    aM

  • Statistics To see the complete set of data Click hereTo see the Next set of entry click here

    CamKII acting as a Product in a Reaction

    Keq is calculated only for first order reactions. Kd is calculated only for second order reactions. [ nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules]
     NameAccession Name
    Accession No.
    Pathway Name
    Pathway No.
    KfKbKdtauReagents
    1 CaMKII-bind-CaMfig3_CaMKII
    Accession No. 2
    CaMKII
    Pathway No. 13
    49.9998
    uM^-1 s^-1
    5
    s^-1
    Kd(bf) = 0.1(uM)-Substrate:
    CaM-Ca4
    CaMKII

    Product:
    CaMKII-CaM
    2
  • CaMK-thr286-bind
    -CaM
  • fig3_CaMKII
    Accession No. 2
    CaMKII
    Pathway No. 13
    1000.2
    uM^-1 s^-1
    0.1
    s^-1
    Kd(bf) = 0.0001(uM)-Substrate:
    CaMKII-thr286
    CaM-Ca4

    Product:
  • CaMKII-thr286*-C
    aM

  • 3 basal-activityfig3_CaMKII
    Accession No. 2
    CaMKII
    Pathway No. 13
    0.003
    s^-1
    0
    s^-1
    --Substrate:
    CaMKII

    Product:
    CaMKII-thr286
    4 CaMKII-bind-CaMfig4_synapse
    Accession No. 3
    CaMKII
    Pathway No. 26
    49.9998
    uM^-1 s^-1
    5
    s^-1
    Kd(bf) = 0.1(uM)-Substrate:
    CaM-Ca4
    CaMKII

    Product:
    CaMKII-CaM
    5
  • CaMK-thr286-bind
    -CaM
  • fig4_synapse
    Accession No. 3
    CaMKII
    Pathway No. 26
    1000.2
    uM^-1 s^-1
    0.1
    s^-1
    Kd(bf) = 0.0001(uM)-Substrate:
    CaMKII-thr286
    CaM-Ca4

    Product:
  • CaMKII-thr286*-C
    aM

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