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Molecule Parameter List for CaTransp-2Ca

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaTransp-2Ca participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • NonOsc_Ca_
    IP3metabolism
  • 31Network
    MIPP CaMKII CaM 
    PKC IP3-3K CaRegulation 
    Gq PLCbeta 134_dephos 
    145_dephos IP4-system IHP-system 
    1345_dephos 
    This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. It is similar to the NonOsc_Ca_IP3metab model (accession 23) except that some enzymes have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. These modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    CaTransp-2Ca acting as a Molecule in  
    NonOsc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    CaTransp-2Ca
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • CaRegulation
    Pathway No. : 149
    01000No
    equivalent to the enzyme-substrate complex. 2 Ca are bound to the transporter. ATP is ignored.

    CaTransp-2Ca acting as a Substrate in a reaction in  
    NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    CaTraspATPase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • CaRegulation
    Pathway No. : 149
    25
    (s^-1)
    0
    (#^-2 s^-1)
    Not applicable**-Substrate
    CaTransp-2Ca

    Product
    Ca-sequester
    Ca-sequester
    CaTransp
    kCa3 = 2 * Ca transporter rate since each step has 2 Ca++. = 0.5 uM/sec from Lauffenburger and Linderman 1993 Receptors pg200 The amount of the activated transporter is about 0.01 uM = 6e3#. from runs. So 0.01uM * kf * 2 = 0.5 uM/sec (no back reaction) so kf = 25, kb = 0 Alternatively, 6e3 * kf = 0.25 * 6e5, giving the same kf
    ** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration

    CaTransp-2Ca acting as a Product in a reaction in  
    NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • Ca-bind-to-Trans
    p
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • CaRegulation
    Pathway No. : 149
    3600
    (uM^-2 s^-1)
    144
    (s^-1)
    Kd(af) = 0.2(uM)-Substrate
    Ca
    Ca
    CaTransp

    Product
    CaTransp-2Ca
    Rates from Lauffenburger abd Linderman 1993 Receptors pg 200. Kd = KCa2 = 0.2 uM



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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