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Molecule Parameter List for PP1-I1*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PP1-I1* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1002001

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig3_CaMKII2Network
Shared_Object_fig3_CaMKII CaMKII CaM 
PP1 PP2B PKA 
AC 
This is the model file for figure 3 from Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It is a model of the Ca activation of CaMKII and other CaM-activated enzymes. It includes the regulatory phosphatases PP1 and PP2B (Calcineurin) acting on CaMKII and also includes CaM-activated adenylyl cyclase and PKA in the synapse.
Demonstration script files for generating the figures in the paper, including figure 3, are available here.

PP1-I1* acting as a Molecule in  
fig3_CaMKII Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
PP1-I1*fig3_CaMKII
Accession No. : 2
PP1
Pathway No. : 15
01000No

PP1-I1* acting as a Substrate for an Enzyme in  
fig3_CaMKII Network
 Enzyme Molecule /
Enzyme Activity
Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
1CaM(Ca)n-CaNAB  /
dephosph-PP1-I*
fig3_CaMKII
Accession No. : 2
  • Shared_Object_
    fig3_CaMKII

    Pathway No. : 12
  • 4.970760.344explicit E-S complexSubstrate
    PP1-I1*

    Product
    PP1-I1
    2PP2A  /
  • PP2A-dephosph-PP
    1-I*
  • fig3_CaMKII
    Accession No. : 2
  • Shared_Object_
    fig3_CaMKII

    Pathway No. : 12
  • 7.8282864.16667explicit E-S complexSubstrate
    PP1-I1*

    Product
    PP1-I1

    PP1-I1* acting as a Product in a reaction in  
    fig3_CaMKII Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    Inact-PP1fig3_CaMKII
    Accession No. : 2
    PP1
    Pathway No. : 15
    499.98
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 0.0002(uM)-Substrate
    I1*
    PP1-active

    Product
    PP1-I1*



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.