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Molecule Parameter List for IP3

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IP3 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1100010

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • NonOsc_Ca_
    IP3metabolism
  • 31Network
    MIPP CaMKII CaM 
    PKC IP3-3K CaRegulation 
    Gq PLCbeta 134_dephos 
    145_dephos IP4-system IHP-system 
    1345_dephos 
    This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. It is similar to the NonOsc_Ca_IP3metab model (accession 23) except that some enzymes have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. These modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    IP3 acting as a Molecule in  
    NonOsc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    IP3
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • CaRegulation
    Pathway No. : 149
    01000No
    Inositol(145)trisphosphate

    IP3 acting as a Summed Molecule in  
    NonOsc_Ca_IP3metabolism Network
    Accession NamePathway NameTargetInput
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • CaRegulation
    Pathway No. : 149
    IP3IP3(145)
    Inositol(145)trisphosphate

    IP3 acting as a Substrate in a reaction in  
    NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    IP3Rbind
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • CaRegulation
    Pathway No. : 149
    0.05
    (uM^-3 s^-1)
    1
    (s^-1)
    Kd(af) = 2.7144(uM)-Substrate
    IP3
    IP3
    IP3
    IP3R

    Product
    IP3R*
    Based on Lauffenburger and Linderman 1993 Receptors pg 200. The binding of IP3 on this reaction had a Hill coeff of 3. The eqns of Mahama and Linderman (cited in the book as 1993 a) are equivalent to the binding all occurring in a single step, so that is how I do it in this version. Their Ki1 is 0.07 uM. Lots of other data sources: Ramos-Franco et al, Biophys J 75, 1998: 834-39 have Ca sensitivity curves. At 250 nM free Ca, the EC50 for type1 is 58 nM and type 2 is 194 nM. Type 3 would be about 2 uM according to Newton et al, JBC 268(46), 1994: 28613-19. For the purposes of this model we use a Kd of 2.7 uM which is high but maybe OK at low calcium. The details of Ca interaction with the IP3R are not included in this model.



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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