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Molecule Parameter List for CaMCa3-CaNAB

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaMCa3-CaNAB participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1100001

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig3_CaMKII2Network
Shared_Object_fig3_CaMKII CaMKII CaM 
PP1 PP2B PKA 
AC 
This is the model file for figure 3 from Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It is a model of the Ca activation of CaMKII and other CaM-activated enzymes. It includes the regulatory phosphatases PP1 and PP2B (Calcineurin) acting on CaMKII and also includes CaM-activated adenylyl cyclase and PKA in the synapse.
Demonstration script files for generating the figures in the paper, including figure 3, are available here.

CaMCa3-CaNAB acting as a Molecule in  
fig3_CaMKII Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
CaMCa3-CaNABfig3_CaMKII
Accession No. : 2
PP2B
Pathway No. : 16
01000No

CaMCa3-CaNAB acting as a Summed Molecule in  
fig3_CaMKII Network
Accession NamePathway NameTargetInput
fig3_CaMKII
Accession No. : 2
  • Shared_Object_
    fig3_CaMKII

    Pathway No. : 12
  • CaM(Ca)n-CaNABCaMCa4-CaNAB
    CaMCa3-CaNAB
    CaMCa2-CANAB

    CaMCa3-CaNAB acting as a Product in a reaction in  
    fig3_CaMKII Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • CaMCa3-bind-CaNA
    B
  • fig3_CaMKII
    Accession No. : 2
    PP2B
    Pathway No. : 16
    2.238
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.4468(uM)-Substrate
    CaM-Ca3
    CaNAB-Ca4

    Product
    CaMCa3-CaNAB



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.