NCBS Home page
Accession List
Pathway List
Search
Authorized Users
Help
News archives

Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.
Search in: Search for Match By

Molecule Parameter List for IP3_3K

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IP3_3K participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1013010

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Osc_Ca_
    IP3metabolism
  • 32Network
    MIPP CaMKII CaM 
    PKC IP3-3K Gq 
    PLCbeta 134_dephos 145_dephos 
    IP4-system IHP-system 1345_dephos 
    CaRegulation Othmer-Tang-model 
    This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It is similar to the Osc_Ca_IP3metab model (accession 24) except that some enzymes in the InsP3 metabolism network have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. The modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    IP3_3K acting as a Molecule in  
    Osc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    IP3_3K
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • IP3-3K
    Pathway No. : 162
    0.38531000No
    from Johanson et al, JBC, 1988, Vol. 263, No.16, pp 7465-7471 this is the predominant isoform in brain ie IP3-3kinaseA: BiochemJ, 1995, 306, 429-435

    IP3_3K acting as an Enzyme in  
    Osc_Ca_IP3metabolism Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    IP3_3K /
    ip3-3k
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • IP3-3K
    Pathway No. : 162
    1.400013.04754explicit E-S complexSubstrate
    IP3(145)

    Product
    IP4(1345)
    from Johanson et al, JBC 263; 1988 Original Vmax scaled up by 50% to obtain value at 37C, as enzyme assay was done at 30C Km increased from 0.2 to 1.4 as per various other reports (Shears Review, BiochemJ 260; 1989)

    IP3_3K acting as a Substrate for an Enzyme in  
    Osc_Ca_IP3metabolism Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1tot_CaM_CaMKII  /
    CaM-CaMK-phos
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • CaMKII
    Pathway No. : 159
    1.600010.54explicit E-S complexSubstrate
    IP3_3K

    Product
    IP3_3K*
        rates referred from standard CaM-CaMKII phosphorylation rates
    2
  • tot_autonomous_
    CaMKII
      /
    CaMK-phos
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • CaMKII
    Pathway No. : 159
    2.499990.54explicit E-S complexSubstrate
    IP3_3K

    Product
    IP3_3K*
        rates referred from standard CaMKII phosphorylation rates
    3PKC-active  /
    PKC-phos
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • PKC
    Pathway No. : 161
    30.000844explicit E-S complexSubstrate
    IP3_3K

    Product
    IP3_3K*1
        rates referred from standard PKC phosphorylation rates

    IP3_3K acting as a Substrate in a reaction in  
    Osc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    3K-bind-CaM
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • IP3-3K
    Pathway No. : 162
    19.2312
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.052(uM)-Substrate
    CaM-Ca4
    IP3_3K

    Product
    IP3_3K_CaM
    Communi et al, EMBO J 16; 1997 non-phosphorylated 3kinase with low sensitivity to CaM binding (Kd = 52nM)



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.