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Molecule Parameter List for G*GDP

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
G*GDP participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000012

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Osc_Ca_
    IP3metabolism
  • 32Network
    MIPP CaMKII CaM 
    PKC IP3-3K Gq 
    PLCbeta 134_dephos 145_dephos 
    IP4-system IHP-system 1345_dephos 
    CaRegulation Othmer-Tang-model 
    This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It is similar to the Osc_Ca_IP3metab model (accession 24) except that some enzymes in the InsP3 metabolism network have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. The modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    G*GDP acting as a Molecule in  
    Osc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    G*GDP
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • Gq
    Pathway No. : 163
    01000No
    This should correctly be called GDP.G_alpha. The name is preserved for backward compatibility reasons.

    G*GDP acting as a Substrate in a reaction in  
    Osc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    Trimerize-G
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • Gq
    Pathway No. : 163
    6
    (uM^-1 s^-1)
    0
    (s^-1)
    --Substrate
    BetaGamma
    G*GDP

    Product
    G-GDP
    kf == kg3 = 1e-5 /cell/sec. As usual, there is no back-reaction kb = 0

    G*GDP acting as a Product in a reaction in  
    Osc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1Inact-G
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • Gq
    Pathway No. : 163
    0.0133
    (s^-1)
    0
    (s^-1)
    --Substrate
    G*GTP

    Product
    G*GDP
      From Berstein et al JBC 267:12 8081-8088 1992, kcat for GTPase activity of Gq is only 0.8/min.
    2Inact-PLC-Gq
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • PLCbeta
    Pathway No. : 164
    1.6667
    (s^-1)
    0
    (uM^-1 s^-1)
    --Substrate
    PLC-Ca-Gq

    Product
    G*GDP
    PLC-Ca
      Rate of 100/min to account for GAP activity of PLC: Biddlecome et al, JBC, 271, 14, 7999-8007, 1996



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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