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Molecule Parameter List for CaMCa4

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaMCa4 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000032

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
CaMKII33Network
Shared_Object_CaMKII CaM CaMKII 
CaN 
This is a deterministic, point kinetics approximation to the dendritic spine CaMKII model described in William R. Holmes J Comput Neurosci. (2000) 8(1):65-85. Rates are the same but the responses differ somewhat because this model does not include the stochastic and diffusive calculations of the original.

CaMCa4 acting as a Molecule in  
CaMKII Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
CaMCa4CaMKII
Accession No. : 33
CaM
Pathway No. : 173
00.1309No

CaMCa4 acting as a Substrate in a reaction in  
CaMKII Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
 NameAccession NamePathway NameKfKbKdtauReagents
1
  • CaMKII-bind-CaMC
    a4
  • CaMKII
    Accession No. : 33
    CaMKII
    Pathway No. : 174
    100.004
    (uM^-1 s^-1)
    4.5
    (s^-1)
    Kd(bf) = 0.045(uM)-Substrate
    CaMCa4
    CaMKII

    Product
    CaMKII-CaMCa4
    2
  • Autonomous-bind-
    CaMCa4
  • CaMKII
    Accession No. : 33
    CaMKII
    Pathway No. : 174
    33.2998
    (uM^-1 s^-1)
    0
    (s^-1)
    --Substrate
    Autonomous
    CaMCa4

    Product
    Trapped-T286
    3CaN-bind-CaMCa4CaMKII
    Accession No. : 33
    CaN
    Pathway No. : 175
    100.004
    (uM^-1 s^-1)
    0.6
    (s^-1)
    Kd(bf) = 0.006(uM)-Substrate
    CaMCa4
    CaN

    Product
    CaN-CaMCa4

    CaMCa4 acting as a Product in a reaction in  
    CaMKII Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1CaMCa3-bind-CaCaMKII
    Accession No. : 33
    CaM
    Pathway No. : 173
    100.004
    (uM^-1 s^-1)
    500
    (s^-1)
    Kd(bf) = 4.9998(uM)-Substrate
    Ca
    CaMCa3

    Product
    CaMCa4
    2
  • Autonomous_
    lose_CaMCa4
  • CaMKII
    Accession No. : 33
    CaMKII
    Pathway No. : 174
    0.02
    (s^-1)
    0
    (uM^-1 s^-1)
    --Substrate
    Trapped-T286

    Product
    Autonomous
    CaMCa4
      Holmes says that this rate is variable, and depends on Ca conc. It is 0.1 when [Ca] = 10 nM, and 0.00355/sec when [Ca] is 1.0 For our purposes, we assume a good steady approx to this rate is 0.02.



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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