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Molecule Parameter List for CaMKII-CaM

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaMKII-CaM participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
CaMKII33Network
Shared_Object_CaMKII,  CaM,  CaMKII,  
CaN 
This is a deterministic, point kinetics approximation to the dendritic spine CaMKII model described in William R. Holmes J Comput Neurosci. (2000) 8(1):65-85. Rates are the same but the responses differ somewhat because this model does not include the stochastic and diffusive calculations of the original.

CaMKII-CaM acting as a Molecule in  CaMKII Network
NameAccession NamePathway NameInitial Conc.
(uM)		Volume
(fL)		Buffered
CaMKII-CaMCaMKII
Accession No. : 33		CaMKII
Pathway No. : 174		00.1309No

CaMKII-CaM acting as a Substrate in a reaction in  CaMKII Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
  • CaMKII-CaM-bind-
    Ca
    		• CaMKII
    Accession No. : 33    		CaMKII
    Pathway No. : 174    		4
    (uM^-1 s^-1)    		20
    (s^-1)    		Kd(bf) = 5(uM)-Substrate
    Ca
    CaMKII-CaM

    Product
    CAMKII-CaMCa

    CaMKII-CaM acting as a Product in a reaction in      CaMKII Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    CaMKII-bind-CaMCaMKII
    Accession No. : 33    		CaMKII
    Pathway No. : 174    		0.2
    (uM^-1 s^-1)    		2700
    (s^-1)    		Kd(bf) = 13500(uM)-Substrate
    CaM
    CaMKII

    Product
    CaMKII-CaM


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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