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Molecule Parameter List for Tot-active-CaMKII

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
Tot-active-CaMKII participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1120000

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
CaMKII33Network
Shared_Object_CaMKII CaM CaMKII 
CaN 
This is a deterministic, point kinetics approximation to the dendritic spine CaMKII model described in William R. Holmes J Comput Neurosci. (2000) 8(1):65-85. Rates are the same but the responses differ somewhat because this model does not include the stochastic and diffusive calculations of the original.

Tot-active-CaMKII acting as a Molecule in  
CaMKII Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
Tot-active-CaMKIICaMKII
Accession No. : 33
CaMKII
Pathway No. : 174
00.1309No

Tot-active-CaMKII acting as a Summed Molecule in  
CaMKII Network
Accession NamePathway NameTargetInput
CaMKII
Accession No. : 33
CaMKII
Pathway No. : 174
Tot-active-CaMKIICaMKII-CaMCa4
Trapped-T286
Capped
Autonomous

Tot-active-CaMKII acting as an Enzyme in  
CaMKII Network
 Enzyme Molecule /
Enzyme Activity
Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
1
  • Tot-active-CaMKI
    I
     /
    phosph_T286
  • CaMKII
    Accession No. : 33
    CaMKII
    Pathway No. : 174
    0.254651100explicit E-S complexSubstrate
    CaMKII-CaMCa4

    Product
    Trapped-T286
        This enzyme represents an intra-holoenzyme reaction from one active subunit to its neighbor. k1 is now in units of 1/sec. The Km, Ratio and Vmax terms are pretty meaningless. The enzyme really is there just to represent the forward rate of 0.5 from CaMKII-CaMCa4 to Trapped-T285. We have a high k3 so that the reac is limited only by k1. The enzyme itself does not have much purpose other than to allow scaling of the overall rate by the proportion of adjacent molecules in the appropriate state.
    2
  • Tot-active-CaMKI
    I
     /
    phosph_T305
  • CaMKII
    Accession No. : 33
    CaMKII
    Pathway No. : 174
    1.27325100explicit E-S complexSubstrate
    Autonomous

    Product
    Capped
        This enzyme also represents an intra-holoenzyme reaction. So it is not really treated as an enzyme in Holme's model, more like a probability of reaction that scales according to the number of active CaMKII neighboring subunits. Here we approximate it as an enzyme rate limited by the k1=0.1 step, no back reaction, and with a scaling from Total_CaMKII such that the effective forward rate will simply be the fraction of CaMKII that are active, times 1/10 for nearest neigbors, times k1.



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