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Molecule Parameter List for craf-1**

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
craf-1** participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1001100

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • MAPK-bistability
    -fig1c
    		• 35Network
    Shared_Object_MAPK-bistability-fig1c,  Sos,  PKC,  
    MAPK,  PLA2,  Ras,  
    PDGFR 
    Model for figure 1c in Bhalla US et al. Science (2002) 297(5583):1018-23.
    The demo for this figure is available here. This synaptic signaling model is without the MKP-1 feedback, so it is bistable and remains so over long periods.

    craf-1** acting as a Molecule in      MAPK-bistability-fig1c Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    craf-1**
  • MAPK-bistability
    -fig1c
    Accession No. : 35
    		• MAPK
    Pathway No. : 182    		01000No
    Negative feedback by MAPK* by hyperphosphorylating craf-1* gives rise to this pool. Ueki et al JBC 269(22):15756-15761, 1994

    craf-1** acting as a Substrate for an Enzyme in      MAPK-bistability-fig1c Network
    Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PPhosphatase2A  /
    craf**-deph
  • MAPK-bistability
    -fig1c
    Accession No. : 35
  • Shared_Object_
    MAPK-bistability
    -fig1c
    Pathway No. : 179
    		• 15.656664.16667explicit E-S complexSubstrate
    craf-1**

    Product
    craf-1*
    Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of craf, so this is there to dephosphorylate it. Identity of phosphatase is assumed to be PP2A.

    craf-1** acting as a Product of an Enzyme in      MAPK-bistability-fig1c Network
    Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    MAPK*  /
    MAPK*-feedback
  • MAPK-bistability
    -fig1c
    Accession No. : 35
  • Shared_Object_
    MAPK-bistability
    -fig1c
    Pathway No. : 179
    		• 25.641104explicit E-S complexSubstrate
    craf-1*

    Product
    craf-1**
    Ueki et al JBC 269(22):15756-15761 show the presence of this step, but not the rate consts, which are derived from Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the MAPK* notes.


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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