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Molecule Parameter List for PDGFR

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PDGFR participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000010

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • MAPK-bistability
    -fig1c
    		• 35Network
    Shared_Object_MAPK-bistability-fig1c,  Sos,  PKC,  
    MAPK,  PLA2,  Ras,  
    PDGFR 
    Model for figure 1c in Bhalla US et al. Science (2002) 297(5583):1018-23.
    The demo for this figure is available here. This synaptic signaling model is without the MKP-1 feedback, so it is bistable and remains so over long periods.

    PDGFR acting as a Molecule in      MAPK-bistability-fig1c Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    PDGFR
  • MAPK-bistability
    -fig1c
    Accession No. : 35
    		• PDGFR
    Pathway No. : 185    		0.10831000No
    Berkers et al JBC 266 say 22K high affinity receptors per cell. Sherrill and Kyte Biochemistry 35 use range 4-200 nM. These values match reasonably. Heidaran et al 1993 JBC 268(13):9287-9295 use NIH3T3 cells and have 6.5e4 receptors/cell. This is also in the same general range. We use this last value because the cell type matches.

    PDGFR acting as a Substrate in a reaction in      MAPK-bistability-fig1c Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    act_PDGFR
  • MAPK-bistability
    -fig1c
    Accession No. : 35
    		• PDGFR
    Pathway No. : 185    		199.998
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0005(uM)-Substrate
    PDGF
    PDGFR

    Product
    L.PDGFR
    From Heidaran et al JBC268(13):9287 Fig 5. Kd is ~0.5 nM


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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