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Molecule Parameter List for AA

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
AA participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000540

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig2_egfr1Network
Shared_Object_fig2_egfr PKC PLA2 
PLCbeta Gq MAPK 
Ras EGFR Sos 
PLC_g CaRegulation 
This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse.
Demonstration script files for generating the figures in the paper, including figure 2, are available here.

AA acting as a Molecule in  
fig2_egfr Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
AAfig2_egfr
Accession No. : 1
  • Shared_Object_
    fig2_egfr

    Pathway No. : 1
  • 01000No

    AA acting as a Product of an Enzyme in  
    fig2_egfr Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1PLA2-Ca*  /
    kenz
    fig2_egfr
    Accession No. : 1
    PLA2
    Pathway No. : 3
    205.44explicit E-S complexSubstrate
    APC

    Product
    AA
    2PIP2-PLA2*  /
    kenz
    fig2_egfr
    Accession No. : 1
    PLA2
    Pathway No. : 3
    2011.044explicit E-S complexSubstrate
    APC

    Product
    AA
    3PIP2-Ca-PLA2*  /
    kenz
    fig2_egfr
    Accession No. : 1
    PLA2
    Pathway No. : 3
    20364explicit E-S complexSubstrate
    APC

    Product
    AA
    4DAG-Ca-PLA2*  /
    kenz
    fig2_egfr
    Accession No. : 1
    PLA2
    Pathway No. : 3
    20604explicit E-S complexSubstrate
    APC

    Product
    AA
    5PLA2*-Ca  /
    kenz
    fig2_egfr
    Accession No. : 1
    PLA2
    Pathway No. : 3
    201204explicit E-S complexSubstrate
    APC

    Product
    AA

    AA acting as a Substrate in a reaction in  
    fig2_egfr Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1
  • PKC-act-by-Ca-AA
  • fig2_egfr
    Accession No. : 1
    PKC
    Pathway No. : 2
    0.0012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 83.3333(uM)-Substrate
    AA
    PKC-Ca

    Product
    PKC-Ca-AA*
    2PKC-act-by-AAfig2_egfr
    Accession No. : 1
    PKC
    Pathway No. : 2
    0.0001
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 833.3333(uM)-Substrate
    AA
    PKC-cytosolic

    Product
    PKC-AA*
    3PKC-n-DAG-AAfig2_egfr
    Accession No. : 1
    PKC
    Pathway No. : 2
    0.018
    (uM^-1 s^-1)
    2
    (s^-1)
    Kd(bf) = 111.1111(uM)-Substrate
    AA
    PKC-DAG

    Product
    PKC-DAG-AA
    4Degrade-AAfig2_egfr
    Accession No. : 1
    PLA2
    Pathway No. : 3
    0.4
    (s^-1)
    0
    (s^-1)
    --Substrate
    AA

    Product
    APC



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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