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Molecule Parameter List for CaM.PDE1

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaM.PDE1 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1010001

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig3_CaMKII2Network
Shared_Object_fig3_CaMKII CaMKII CaM 
PP1 PP2B PKA 
AC 
This is the model file for figure 3 from Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It is a model of the Ca activation of CaMKII and other CaM-activated enzymes. It includes the regulatory phosphatases PP1 and PP2B (Calcineurin) acting on CaMKII and also includes CaM-activated adenylyl cyclase and PKA in the synapse.
Demonstration script files for generating the figures in the paper, including figure 3, are available here.

CaM.PDE1 acting as a Molecule in  
fig3_CaMKII Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
CaM.PDE1fig3_CaMKII
Accession No. : 2
AC
Pathway No. : 18
01000No

CaM.PDE1 acting as an Enzyme in  
fig3_CaMKII Network
Enzyme Molecule /
Enzyme Activity
Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
CaM.PDE1 /
CaM.PDE1
fig3_CaMKII
Accession No. : 2
AC
Pathway No. : 18
39.6825104explicit E-S complexSubstrate
cAMP

Product
AMP

CaM.PDE1 acting as a Product in a reaction in  
fig3_CaMKII Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
CaM_bind_PDE1fig3_CaMKII
Accession No. : 2
AC
Pathway No. : 18
720
(uM^-1 s^-1)
5
(s^-1)
Kd(bf) = 0.0069(uM)-Substrate
CaM-Ca4
PDE1

Product
CaM.PDE1



Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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