NCBS Home page
Accession List
Pathway List
Search
Authorized Users
Help
News archives

Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.
Search in: Search for Match By

Molecule Parameter List for A2

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
A2 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000020

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • MAPK_Asthagiri_
    adapt_fb
  • 45Pathway
    MAPK 
    This is a complex model to examine mechanisms that govern MAPK pathway dynamics in Chinese hamster ovary (CHO) cell lines, particularly the role of adapter targeted negative feedback mechanism in generating complete signal adaptation. This model simulates the results as per the figure 7A of the paper by Asthagiri AR and Lauffenburger DA. Biotechnol Prog. (2001) 17(2):227-39.

    A2 acting as a Molecule in  
    MAPK_Asthagiri_adapt_fb Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    A2
  • MAPK_Asthagiri_
    adapt_fb

    Accession No. : 45
  • MAPK
    Pathway No. : 193
    0.0427390No
    Second adaptor protein. Tot.no. 10^4 no./cell from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39

    A2 acting as a Substrate in a reaction in  
    MAPK_Asthagiri_adapt_fb Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1C*A1-bind-A2
  • MAPK_Asthagiri_
    adapt_fb

    Accession No. : 45
  • MAPK
    Pathway No. : 193
    5.0001
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.1(uM)-Substrate
    A2
    C*A1

    Product
    E0*
      kf2 and kr2 are 3*10^8 M-1 min-1 and 0.5/sec from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39
    2A1-bind-A2
  • MAPK_Asthagiri_
    adapt_fb

    Accession No. : 45
  • MAPK
    Pathway No. : 193
    5.0001
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.1(uM)-Substrate
    A1
    A2

    Product
    A1A2
      Kc12 and Kd12 are 3*10^8 M-1 min-1 and 0.5/sec from Asthagiri and Lauffenburger 2001.



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.