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Molecule Parameter List for E1*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
E1* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1011100

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • MAPK_Asthagiri_
    adapt_fb
  • 45Pathway
    MAPK 
    This is a complex model to examine mechanisms that govern MAPK pathway dynamics in Chinese hamster ovary (CHO) cell lines, particularly the role of adapter targeted negative feedback mechanism in generating complete signal adaptation. This model simulates the results as per the figure 7A of the paper by Asthagiri AR and Lauffenburger DA. Biotechnol Prog. (2001) 17(2):227-39.

    E1* acting as a Molecule in  
    MAPK_Asthagiri_adapt_fb Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    E1*
  • MAPK_Asthagiri_
    adapt_fb

    Accession No. : 45
  • MAPK
    Pathway No. : 193
    0390No
    Active form of enzyme from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39

    E1* acting as an Enzyme in  
    MAPK_Asthagiri_adapt_fb Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    E1* /
    E2_activ
  • MAPK_Asthagiri_
    adapt_fb

    Accession No. : 45
  • MAPK
    Pathway No. : 193
    0.06000010.15explicit E-S complexSubstrate
    E2

    Product
    E2*
    k2+ =6*10^8 M-1 min-1, k2- =30 min-1, kcat,2 =6 min-1 from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39

    E1* acting as a Substrate for an Enzyme in  
    MAPK_Asthagiri_adapt_fb Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    P1  /
    E1*_deactiv
  • MAPK_Asthagiri_
    adapt_fb

    Accession No. : 45
  • MAPK
    Pathway No. : 193
    0.06000010.15explicit E-S complexSubstrate
    E1*

    Product
    E1
    kp1+ =6*10^8 M-1 min-1, kp1- =30 min-1, kpcat,1 =6 min-1 form Asthagiri and Lauffenburger 2001.

    E1* acting as a Product of an Enzyme in  
    MAPK_Asthagiri_adapt_fb Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    E0*  /
    E1_activ
  • MAPK_Asthagiri_
    adapt_fb

    Accession No. : 45
  • MAPK
    Pathway No. : 193
    0.06000010.15explicit E-S complexSubstrate
    E1

    Product
    E1*
    k1+ =6*10^8 M-1 min-1, k1- =30 min-1, kcat,1 =6 min-1 and km caluculated to 0.06 from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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