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Molecule Parameter List for A2-

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
A2- participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000100

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • MAPK_Asthagiri_
    adapt_fb
    		• 45Pathway
    MAPK 
    This is a complex model to examine mechanisms that govern MAPK pathway dynamics in Chinese hamster ovary (CHO) cell lines, particularly the role of adapter targeted negative feedback mechanism in generating complete signal adaptation. This model simulates the results as per the figure 7A of the paper by Asthagiri AR and Lauffenburger DA. Biotechnol Prog. (2001) 17(2):227-39.

    A2- acting as a Molecule in      MAPK_Asthagiri_adapt_fb Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    A2-
  • MAPK_Asthagiri_
    adapt_fb
    Accession No. : 45
    		• MAPK
    Pathway No. : 193    		0390No
    Nonfunctional second adaptor enzyme A2- from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39

    A2- acting as a Product of an Enzyme in      MAPK_Asthagiri_adapt_fb Network
    Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    E4*  /
    E4*_adpt_fb
  • MAPK_Asthagiri_
    adapt_fb
    Accession No. : 45
    		• MAPK
    Pathway No. : 193    		0.06000010.15explicit E-S complexSubstrate
    E0*

    Product
    A2-
    Implementation of adapter feedback induces adaptation of not only the target signal e0* but also signals downstream of the target. k5+ =6*10^8 M-1 min-1, k5- =30 min-1, kcat,5 =6 min-1 from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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