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Molecule Parameter List for GDP.Ga

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
GDP.Ga participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
PKA_200347Network
Shared_Object_PKA_2003 PKA AC 
Gs 
This model consists of receptor-ligand interaction, G-protein activation, Adenylyl cyclase mediated formation of cAMP and activation of PKA in the neuron. Demonstration programs using this model described in Bhalla US. (2004) Biophys J. 87(2):733-44 to generate a dose-response curve using stochastic calculations are available here.

GDP.Ga acting as a Molecule in  
PKA_2003 Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
GDP.GaPKA_2003
Accession No. : 47
Gs
Pathway No. : 198
01000No
The inactive GDP-bound form of Gs alpha.

GDP.Ga acting as a Substrate in a reaction in  
PKA_2003 Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
Trimerize-GsPKA_2003
Accession No. : 47
Gs
Pathway No. : 198
6
(uM^-1 s^-1)
0
(s^-1)
--Substrate
GDP.Ga
Gbg

Product
GDP.Gabc
Negligible back-reaction.

GDP.Ga acting as a Product in a reaction in  
PKA_2003 Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
GTPasePKA_2003
Accession No. : 47
Gs
Pathway No. : 198
0.0667
(s^-1)
0
(s^-1)
--Substrate
GTP.Ga

Product
GDP.Ga
From Brandt and Ross JBC 261(4):1656-1664, rate is 4/min and is agonist independent. I treat this as irreversible.



Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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