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Molecule Parameter List for Gbg

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
Gbg participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
PKA_200347Network
Shared_Object_PKA_2003 PKA AC 
Gs 
This model consists of receptor-ligand interaction, G-protein activation, Adenylyl cyclase mediated formation of cAMP and activation of PKA in the neuron. Demonstration programs using this model described in Bhalla US. (2004) Biophys J. 87(2):733-44 to generate a dose-response curve using stochastic calculations are available here.

Gbg acting as a Molecule in  
PKA_2003 Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
GbgPKA_2003
Accession No. : 47
Gs
Pathway No. : 198
01000No
The Gbetagamma dimer.

Gbg acting as a Substrate in a reaction in  
PKA_2003 Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
Trimerize-GsPKA_2003
Accession No. : 47
Gs
Pathway No. : 198
6
(uM^-1 s^-1)
0
(s^-1)
--Substrate
GDP.Ga
Gbg

Product
GDP.Gabc
Negligible back-reaction.

Gbg acting as a Product in a reaction in  
PKA_2003 Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
Activate-GsPKA_2003
Accession No. : 47
Gs
Pathway No. : 198
0.025
(s^-1)
0
(uM^-2 s^-1)
--Substrate
L.R.GDP.Gabc

Product
GTP.Ga
Gbg
L.R
This step combines several stages in GTP.Galpha release. From Berstein et al activation is at .35 - 0.7/min From Fay et al Biochem 30 5066-5075 1991 kf = .01/sec. From Brandt and Ross JBC 261(4):1656-1664 (1986) and Ransan et al Biochem J 283(2):519-524 (1992) rates around 2.5/min to 1.5/min are better.



Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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