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Molecule Parameter List for PKC-DAG-memb*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PKC-DAG-memb* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1100001

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
PKC_200348Pathway
PKC_2003 PKC 
This model consists of receptor-ligand interaction, G-protein activation, Adenylyl cyclase mediated formation of cAMP and activation of PKA in the neuron. Demonstration programs using this model described in Bhalla US. (2004) Biophys J. 87(2):733-44 to generate a dose-response curve using stochastic calculations are available here.

PKC-DAG-memb* acting as a Molecule in  
PKC_2003 Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
PKC-DAG-memb*PKC_2003
Accession No. : 48
PKC
Pathway No. : 200
01000No

PKC-DAG-memb* acting as a Summed Molecule in  
PKC_2003 Network
Accession NamePathway NameTargetInput
PKC_2003
Accession No. : 48
PKC_2003
Pathway No. : 199
PKC-activePKC-DAG-AA*
PKC-Ca-memb*
PKC-Ca-AA*
PKC-DAG-memb*
PKC-basal*
PKC-AA*
Conc of PKC in brain is about 1 uM (?)

PKC-DAG-memb* acting as a Product in a reaction in  
PKC_2003 Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
PKC-DAG-to-membPKC_2003
Accession No. : 48
PKC
Pathway No. : 200
1
(s^-1)
0.1
(s^-1)
Keq = 0.1(uM)0.909secSubstrate
PKC-Ca-DAG

Product
PKC-DAG-memb*
Raise kb from .087 to 0.1 to match data from Shinomura et al. Lower kf from 1.155 to 1.0 to match data from Shinomura et al.



Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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