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Molecule Parameter List for PKC-DAG-AA

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PKC-DAG-AA participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
PKC_200348Pathway
PKC_2003 PKC 
This model consists of receptor-ligand interaction, G-protein activation, Adenylyl cyclase mediated formation of cAMP and activation of PKA in the neuron. Demonstration programs using this model described in Bhalla US. (2004) Biophys J. 87(2):733-44 to generate a dose-response curve using stochastic calculations are available here.

PKC-DAG-AA acting as a Molecule in  
PKC_2003 Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
PKC-DAG-AAPKC_2003
Accession No. : 48
PKC
Pathway No. : 200
01000No

PKC-DAG-AA acting as a Substrate in a reaction in  
PKC_2003 Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
  • PKC-act-by-DAG-A
    A
  • PKC_2003
    Accession No. : 48
    PKC
    Pathway No. : 200
    2
    (s^-1)
    0.2
    (s^-1)
    Keq = 0.1(uM)0.455secSubstrate
    PKC-DAG-AA

    Product
    PKC-DAG-AA*
    Assume slowish too. Schaechter and Benowitz

    PKC-DAG-AA acting as a Product in a reaction in  
    PKC_2003 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    PKC-n-DAG-AAPKC_2003
    Accession No. : 48
    PKC
    Pathway No. : 200
    0.018
    (uM^-1 s^-1)
    2
    (s^-1)
    Kd(bf) = 111.1111(uM)-Substrate
    AA
    PKC-DAG

    Product
    PKC-DAG-AA
    Reduced kf to 0.66X to match Shinomura et al data. Initial: kf = 3.3333e-9 New: 2e-9 Newer: 2e-8 kb was 0.2 now 2.



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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