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Molecule Parameter List for neurogranin*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
neurogranin* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1001210

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
CaMKII_200349Network
Shared_Object_CaMKII_2003 CaMKII CaM 
PP1 PP2B 
Model of regulation of CaMKII by Calcium, including parallel excitatory input from CaM and inhibitory input from PP1 as regulated by Calcineurin and PKA. Cell type: neuronal.
Bhalla US. Biophys J. 2004 Aug;87(2):733-44.

neurogranin* acting as a Molecule in  
CaMKII_2003 Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
neurogranin*CaMKII_2003
Accession No. : 49
CaM
Pathway No. : 203
01000No
The phosph form does not bind CaM (Huang et al ABB 305:2 570-580 1993)

neurogranin* acting as a Substrate for an Enzyme in  
CaMKII_2003 Network
Enzyme Molecule /
Enzyme Activity
Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
CaM(Ca)n-CaNAB  /
  • dephosph_
    neurogranin
  • CaMKII_2003
    Accession No. : 49
  • Shared_Object_
    CaMKII_2003

    Pathway No. : 201
  • 10.0120.673.98507explicit E-S complexSubstrate
    neurogranin*

    Product
    neurogranin
    From Seki et al ABB 316(2):673-679

    neurogranin* acting as a Product of an Enzyme in  
    CaMKII_2003 Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1PKC-active  /
  • PKC-phosph-neuro
    granin
  • CaMKII_2003
    Accession No. : 49
  • Shared_Object_
    CaMKII_2003

    Pathway No. : 201
  • 28.62750.584.03448explicit E-S complexSubstrate
    neurogranin

    Product
    neurogranin*
        Rates from Huang et al ABB 305:2 570-580 1993
    2PKC-active  /
  • PKC-phosph-ng-Ca
    M
  • CaMKII_2003
    Accession No. : 49
  • Shared_Object_
    CaMKII_2003

    Pathway No. : 201
  • 28.59480.354explicit E-S complexSubstrate
    neurogranin-CaM

    Product
    CaM
    neurogranin*
        Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993

    neurogranin* acting as a Substrate in a reaction in  
    CaMKII_2003 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • dephosph-neurogr
    anin
  • CaMKII_2003
    Accession No. : 49
    CaM
    Pathway No. : 203
    0.005
    (s^-1)
    0
    (s^-1)
    --Substrate
    neurogranin*

    Product
    neurogranin
    This is put in to keep the basal levels of neurogranin* experimentally reasonable. From various papers, specially Ramakers et al JBC 270:23 1995 13892-13898, it looks like the basal level of phosph is between 20 and 40%. I est around 25 % The kf of 0.005 gives around this level at basal PKC activity levels of 0.1 uM active PKC.



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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