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Molecule Parameter List for CaMKII***

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaMKII*** participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1102200

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • MAPK_network_
    2003
  • 50Network
    Shared_Object_MAPK_network_2003 PKC PLA2 
    PLCbeta Gq MAPK 
    Ras EGFR Sos 
    PLC_g CaMKII CaM 
    PP1 PP2B PKA 
    AC 
    This is a network model of many pathways present at the neuronal synapse. The network has properties of temporal tuning as well as steady-state computational properties. In its default form the network is bistable.Bhalla US Biophys J. 2004 Aug;87(2):745-53

    CaMKII*** acting as a Molecule in  
    MAPK_network_2003 Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    CaMKII***
  • MAPK_network_
    2003

    Accession No. : 50
  • CaMKII
    Pathway No. : 216
    01000No
    From Hanson and Schulman, the CaMKII does a lot of autophosphorylation just after the CaM is released. This prevents further CaM binding and renders the enzyme quite independent of Ca.

    CaMKII*** acting as a Summed Molecule in  
    MAPK_network_2003 Network
    Accession NamePathway NameTargetInput
  • MAPK_network_
    2003

    Accession No. : 50
  • CaMKII
    Pathway No. : 216
    tot_autonomous_CaMKIICaMKII-thr286
    CaMKII***

    CaMKII*** acting as a Substrate for an Enzyme in  
    MAPK_network_2003 Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1PP1-active  /
    Deph-thr305
  • MAPK_network_
    2003

    Accession No. : 50
  • Shared_Object_
    MAPK_network_
    2003

    Pathway No. : 206
  • 5.099070.354explicit E-S complexSubstrate
    CaMKII***

    Product
    CaMKII-thr286
    2PP1-active  /
    Deph-thr286c
  • MAPK_network_
    2003

    Accession No. : 50
  • Shared_Object_
    MAPK_network_
    2003

    Pathway No. : 206
  • 5.099070.354explicit E-S complexSubstrate
    CaMKII***

    Product
    CaMK-thr306

    CaMKII*** acting as a Product of an Enzyme in  
    MAPK_network_2003 Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1tot_CaM_CaMKII  /
    CaM_act_305
  • MAPK_network_
    2003

    Accession No. : 50
  • CaMKII
    Pathway No. : 216
    113.664explicit E-S complexSubstrate
    CaMKII-thr286

    Product
    CaMKII***
        Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5.
    2
  • tot_autonomous_
    CaMKII
      /
    auton_305
  • MAPK_network_
    2003

    Accession No. : 50
  • CaMKII
    Pathway No. : 216
    175.00364explicit E-S complexSubstrate
    CaMKII-thr286

    Product
    CaMKII***
        See Hanson and Schulman again, for afterburst rates of phosph.



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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