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Molecule Parameter List for IP3

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IP3 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000210

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig4_synapse3Network
Shared_Object_fig4_synapse PKC PLA2 
PLCbeta Gq MAPK 
Ras CaMKII CaM 
PP1 PP2B PKA 
AC 
This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper.
Demonstration script files for generating the figures in the paper, including figure 4, are available here.

IP3 acting as a Molecule in  
fig4_synapse Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
IP3fig4_synapse
Accession No. : 3
  • Shared_Object_
    fig4_synapse

    Pathway No. : 19
  • 01000No

    IP3 acting as a Product of an Enzyme in  
    fig4_synapse Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1PLC-Ca  /
    PLC-Ca
    fig4_synapse
    Accession No. : 3
    PLCbeta
    Pathway No. : 22
    19.8413104explicit E-S complexSubstrate
    PIP2

    Product
    DAG
    IP3
    2PLC-Ca-Gq  /
    PLCb-Ca-Gq
    fig4_synapse
    Accession No. : 3
    PLCbeta
    Pathway No. : 22
    5484explicit E-S complexSubstrate
    PIP2

    Product
    DAG
    IP3

    IP3 acting as a Substrate in a reaction in  
    fig4_synapse Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    Degrade-IP3fig4_synapse
    Accession No. : 3
    PLCbeta
    Pathway No. : 22
    1
    (s^-1)
    0
    (s^-1)
    --Substrate
    IP3

    Product
    Inositol



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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