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Molecule Parameter List for PLC

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PLC participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000020

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig4_synapse3Network
Shared_Object_fig4_synapse PKC PLA2 
PLCbeta Gq MAPK 
Ras CaMKII CaM 
PP1 PP2B PKA 
AC 
This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper.
Demonstration script files for generating the figures in the paper, including figure 4, are available here.

PLC acting as a Molecule in  
fig4_synapse Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
PLCfig4_synapse
Accession No. : 3
PLCbeta
Pathway No. : 22
0.81000No

PLC acting as a Substrate in a reaction in  
fig4_synapse Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
 NameAccession NamePathway NameKfKbKdtauReagents
1Act-PLC-Cafig4_synapse
Accession No. : 3
PLCbeta
Pathway No. : 22
3
(uM^-1 s^-1)
1
(s^-1)
Kd(bf) = 0.3333(uM)-Substrate
Ca
PLC

Product
PLC-Ca
2PLC-bind-Gqfig4_synapse
Accession No. : 3
PLCbeta
Pathway No. : 22
2.52
(uM^-1 s^-1)
1
(s^-1)
Kd(bf) = 0.3968(uM)-Substrate
G*GTP
PLC

Product
PLC-Gq



Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.