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Molecule Parameter List for MAPK*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
MAPK* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1021100

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
EGFR_MAPK58Network
Shared_Object_EGFR_MAPK MAPK Ras 
EGFR Sos 
Model of MAPK activation by EGFR in the synapse. Demonstration programs using this model are available here.
Primary citation:Bhalla US. Biophys J. (2004) 87(2):745-53.

MAPK* acting as a Molecule in  
EGFR_MAPK Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
MAPK*EGFR_MAPK
Accession No. : 58
  • Shared_Object_
    EGFR_MAPK

    Pathway No. : 229
  • 01000No

    MAPK* acting as an Enzyme in  
    EGFR_MAPK Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1MAPK* /
    MAPK*-feedback
    EGFR_MAPK
    Accession No. : 58
  • Shared_Object_
    EGFR_MAPK

    Pathway No. : 229
  • 25.641104explicit E-S complexSubstrate
    craf-1*

    Product
    craf-1**
        Ueki et al JBC 269(22):15756-15761 show the presence of this step, but not the rate consts, which are derived from Sanghera et al JBC 265(1):52-57, 1990, see the deriv in the MAPK* notes.
    2MAPK* /
    phosph_Sos
    EGFR_MAPK
    Accession No. : 58
  • Shared_Object_
    EGFR_MAPK

    Pathway No. : 229
  • 2.5641104explicit E-S complexSubstrate
    Sos

    Product
    Sos*
        See Porfiri and McCormick JBC 271:10 pp5871 1996 for the existence of this step. We'll take the rates from the ones used for the phosph of Raf by MAPK. Sep 17 1997: The transient activation curve matches better with k1 up by 10 x.

    MAPK* acting as a Substrate for an Enzyme in  
    EGFR_MAPK Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    MKP-1  /
    MKP1-thr-deph
    EGFR_MAPK
    Accession No. : 58
  • Shared_Object_
    EGFR_MAPK

    Pathway No. : 229
  • 0.066666714explicit E-S complexSubstrate
    MAPK*

    Product
    MAPK-tyr
    See MKP1-tyr-deph

    MAPK* acting as a Product of an Enzyme in  
    EGFR_MAPK Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    MAPKK*  /
    MAPKKthr
    EGFR_MAPK
    Accession No. : 58
    MAPK
    Pathway No. : 230
    0.04629630.154explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
    Rate consts same as for MAPKKtyr.



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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