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Molecule Parameter List for Shc*.Sos.Grb2

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
Shc*.Sos.Grb2 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1010001

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
EGFR_MAPK58Network
Shared_Object_EGFR_MAPK,  MAPK,  Ras,  
EGFR,  Sos 
Model of MAPK activation by EGFR in the synapse. Demonstration programs using this model are available here.
Primary citation:Bhalla US. Biophys J. (2004) 87(2):745-53.

Shc*.Sos.Grb2 acting as a Molecule in  EGFR_MAPK Network
NameAccession NamePathway NameInitial Conc.
(uM)		Volume
(fL)		Buffered
Shc*.Sos.Grb2EGFR_MAPK
Accession No. : 58
  • Shared_Object_
    EGFR_MAPK
    Pathway No. : 229
    		• 01000No

    Shc*.Sos.Grb2 acting as an Enzyme in      EGFR_MAPK Network
    Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    Shc*.Sos.Grb2 /
    Sos.Ras_GEF
    		EGFR_MAPK
    Accession No. : 58
  • Shared_Object_
    EGFR_MAPK
    Pathway No. : 229
    		• 0.5050510.024explicit E-S complexSubstrate
    GDP-Ras

    Product
    GTP-Ras

    Shc*.Sos.Grb2 acting as a Product in a reaction in      EGFR_MAPK Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • Shc_bind_
    Sos.Grb2
    		• EGFR_MAPK
    Accession No. : 58    		Sos
    Pathway No. : 233    		0.5
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.2(uM)-Substrate
    SHC*
    Sos.Grb2

    Product
    Shc*.Sos.Grb2
    Sasaoka et al JBC 269:51 pp 32621 1994, table on pg 32623 indicates that this pathway accounts for about 50% of the GEF activation. (88% - 39%). Error is large, about 20%. Fig 1 is most useful in constraining rates. Chook et al JBC 271:48 pp 30472, 1996 say that the Kd is 0.2 uM for Shc binding to EGFR. The Kd for Grb direct binding is 0.7, so we'll ignore it.


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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