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Molecule Parameter List for Sos*.Grb2

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
Sos*.Grb2 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000001

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
EGFR_MAPK58Network
Shared_Object_EGFR_MAPK MAPK Ras 
EGFR Sos 
Model of MAPK activation by EGFR in the synapse. Demonstration programs using this model are available here.
Primary citation:Bhalla US. Biophys J. (2004) 87(2):745-53.

Sos*.Grb2 acting as a Molecule in  
EGFR_MAPK Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
Sos*.Grb2EGFR_MAPK
Accession No. : 58
Sos
Pathway No. : 233
01000No

Sos*.Grb2 acting as a Product in a reaction in  
EGFR_MAPK Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
Grb2_bind_Sos*EGFR_MAPK
Accession No. : 58
Sos
Pathway No. : 233
0.025
(uM^-1 s^-1)
0.0168
(s^-1)
Kd(bf) = 0.672(uM)-Substrate
Grb2
Sos*

Product
Sos*.Grb2
Same rates as Grb2_bind_Sos: Porfiri and McCormick JBC 271:10 pp 5871 1996 show that the binding is not affected by the phosph.



Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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