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Molecule Parameter List for BetaGamma

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
BetaGamma participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000010

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
EGFR_MAPK58Network
Shared_Object_EGFR_MAPK,  MAPK,  Ras,  
EGFR,  Sos 
Model of MAPK activation by EGFR in the synapse. Demonstration programs using this model are available here.
Primary citation:Bhalla US. Biophys J. (2004) 87(2):745-53.

BetaGamma acting as a Molecule in  EGFR_MAPK Network
NameAccession NamePathway NameInitial Conc.
(uM)		Volume
(fL)		Buffered
BetaGammaEGFR_MAPK
Accession No. : 58
  • Shared_Object_
    EGFR_MAPK
    Pathway No. : 229
    		• 0.00941000Yes
    These exist in a nebulous sense in this model, basically only to balance the conservation equations. The details of their reassociation with G-GDP are not modeled Resting level =0.0094, stim level =.0236 from all42.g ish.

    BetaGamma acting as a Substrate in a reaction in      EGFR_MAPK Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    bg-act-GEFEGFR_MAPK
    Accession No. : 58    		Ras
    Pathway No. : 231    		6
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.1667(uM)-Substrate
    BetaGamma
    inact-GEF

    Product
    GEF-Gprot-bg
    SoS/GEF is present at 50 nM ie 3e4/cell. BetaGamma maxes out at 9e4. Assume we have 1/3 of the GEF active when the BetaGamma is 1.5e4. so 1e4 * kb = 2e4 * 1.5e4 * kf, so kf/kb = 3e-5. The rate of this equil should be reasonably fast, say 1/sec


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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