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Molecule Parameter List for CaMKII-thr286*-CaM

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaMKII-thr286*-CaM participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1201211

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • AMPAR_traff_
    model0
  • 59Network
    Shared_Object_AMPAR_traff_model0 CaMKII CaM 
    PP1 PP2B PP1_PSD 
    PKA AC AMPAR 
    AMPAR_memb 
    This is model 0 from Hayer and Bhalla, PLoS Comput Biol 2005. It has a bistable model of AMPAR traffick, plus a non-bistable model of CaMKII. This differs from the reference model (model 1) in that model0 lacks degradation and turno ver reactions for AMPAR.

    CaMKII-thr286*-CaM acting as a Molecule in  
    AMPAR_traff_model0 Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    CaMKII-thr286*-CaM
  • AMPAR_traff_
    model0

    Accession No. : 59
  • CaMKII
    Pathway No. : 235
    00.09No
    From Hanson and Schulman, the thr286 is responsible for autonomous activation of CaMKII.

    CaMKII-thr286*-CaM acting as a Summed Molecule in  
    AMPAR_traff_model0 Network
     Accession NanePathway NameTargetInput
    1
  • AMPAR_traff_
    model0

    Accession No. : 59
  • CaMKII
    Pathway No. : 235
    tot_CaM_CaMKIICaMKII-CaM
  • CaMKII-thr286*-C
    aM

  • 2
  • AMPAR_traff_
    model0

    Accession No. : 59
  • CaMKII
    Pathway No. : 235
    tot_CaMKII_cytCaMKII-CaM
  • CaMKII-thr286*-C
    aM

    CaMKII-thr286
    CaMKII***
    CaMK-thr305
    CaMKII
  • basal_CaMKII_
    cyt


  • CaMKII-thr286*-CaM acting as a Substrate for an Enzyme in  
    AMPAR_traff_model0 Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PP1-active  /
    Deph-thr286
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PP1
    Pathway No. : 237
    5.099052.54explicit E-S complexSubstrate
  • CaMKII-thr286*-C
    aM


    Product
    CaMKII-CaM

  • CaMKII-thr286*-CaM acting as a Product of an Enzyme in  
    AMPAR_traff_model0 Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1tot_CaM_CaMKII  /
    CaM_act_286
  • AMPAR_traff_
    model0

    Accession No. : 59
  • CaMKII
    Pathway No. : 235
    113.6020.54explicit E-S complexSubstrate
    CaMKII-CaM

    Product
  • CaMKII-thr286*-C
    aM

  • 2
  • tot_autonomous_
    CaMKII
      /
    auton_286
  • AMPAR_traff_
    model0

    Accession No. : 59
  • CaMKII
    Pathway No. : 235
    174.9940.54explicit E-S complexSubstrate
    CaMKII-CaM

    Product
  • CaMKII-thr286*-C
    aM


  • CaMKII-thr286*-CaM acting as a Substrate in a reaction in  
    AMPAR_traff_model0 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    transloc_2
  • AMPAR_traff_
    model0

    Accession No. : 59
  • CaMKII
    Pathway No. : 235
    0
    (#^-1 s^-1)
    0
    (s^-1)
    Not applicable**-Substrate
  • CaMKII-thr286*-C
    aM

    NMDAR

    Product
  • CaMKII-thr286-Ca
    M-PSD

  • Same as for transloc_1
    ** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration

    CaMKII-thr286*-CaM acting as a Product in a reaction in  
    AMPAR_traff_model0 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • CaMK-thr286-bind
    -CaM
  • AMPAR_traff_
    model0

    Accession No. : 59
  • CaMKII
    Pathway No. : 235
    1000.19
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 0.0001(uM)-Substrate
    CaM-Ca4
    CaMKII-thr286

    Product
  • CaMKII-thr286*-C
    aM

  • Affinity is up 1000X. Time to release is about 20 sec, so the kb is OK at 0.1 This makes Kf around 1.6666e-3



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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