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Molecule Parameter List for CaMK-thr305

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaMK-thr305 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1101101

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • AMPAR_traff_
    model0
  • 59Network
    Shared_Object_AMPAR_traff_model0 CaMKII CaM 
    PP1 PP2B PP1_PSD 
    PKA AC AMPAR 
    AMPAR_memb 
    This is model 0 from Hayer and Bhalla, PLoS Comput Biol 2005. It has a bistable model of AMPAR traffick, plus a non-bistable model of CaMKII. This differs from the reference model (model 1) in that model0 lacks degradation and turno ver reactions for AMPAR.

    CaMK-thr305 acting as a Molecule in  
    AMPAR_traff_model0 Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    CaMK-thr305
  • AMPAR_traff_
    model0

    Accession No. : 59
  • CaMKII
    Pathway No. : 235
    00.09No
    This forms due to basal autophosphorylation, but I think it has to be considered as a pathway even if some CaM is floating around. In either case it will tend to block further binding of CaM, and will not display any enzyme activity. See Hanson and Schulman JBC 267:24 pp17216-17224 1992

    CaMK-thr305 acting as a Summed Molecule in  
    AMPAR_traff_model0 Network
    Accession NamePathway NameTargetInput
  • AMPAR_traff_
    model0

    Accession No. : 59
  • CaMKII
    Pathway No. : 235
    tot_CaMKII_cytCaMKII-CaM
  • CaMKII-thr286*-C
    aM

    CaMKII-thr286
    CaMKII***
    CaMK-thr305
    CaMKII
  • basal_CaMKII_
    cyt


  • CaMK-thr305 acting as a Substrate for an Enzyme in  
    AMPAR_traff_model0 Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PP1-active  /
    Deph-thr305a
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PP1
    Pathway No. : 237
    5.099052.54explicit E-S complexSubstrate
    CaMK-thr305

    Product
    CaMKII

    CaMK-thr305 acting as a Product of an Enzyme in  
    AMPAR_traff_model0 Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PP1-active  /
    Deph-thr286c
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PP1
    Pathway No. : 237
    5.099052.54explicit E-S complexSubstrate
    CaMKII***

    Product
    CaMK-thr305

    CaMK-thr305 acting as a Product in a reaction in  
    AMPAR_traff_model0 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    back_2
  • AMPAR_traff_
    model0

    Accession No. : 59
  • CaMKII
    Pathway No. : 235
    0.3
    (s^-1)
    0
    (#^-1 s^-1)
    Not applicable**-Substrate
  • CaMKII-thr305-PS
    D


    Product
    CaMK-thr305
    NMDAR
  • Same as for back_1
    ** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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