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Molecule Parameter List for CaMKII-CaM-PSD

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaMKII-CaM-PSD participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1202112

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • AMPAR_traff_
    model0
  • 59Network
    Shared_Object_AMPAR_traff_model0 CaMKII CaM 
    PP1 PP2B PP1_PSD 
    PKA AC AMPAR 
    AMPAR_memb 
    This is model 0 from Hayer and Bhalla, PLoS Comput Biol 2005. It has a bistable model of AMPAR traffick, plus a non-bistable model of CaMKII. This differs from the reference model (model 1) in that model0 lacks degradation and turno ver reactions for AMPAR.

    CaMKII-CaM-PSD acting as a Molecule in  
    AMPAR_traff_model0 Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    CaMKII-CaM-PSD
  • AMPAR_traff_
    model0

    Accession No. : 59
  • CaMKII
    Pathway No. : 235
    00.01No

    CaMKII-CaM-PSD acting as a Summed Molecule in  
    AMPAR_traff_model0 Network
     Accession NanePathway NameTargetInput
    1
  • AMPAR_traff_
    model0

    Accession No. : 59
  • CaMKII
    Pathway No. : 235
    actCaMKII-PSD
  • CaMKII-thr286-Ca
    M-PSD

    CaMKII-CaM-PSD
    tot-auto-PSD
  • 2
  • AMPAR_traff_
    model0

    Accession No. : 59
  • CaMKII
    Pathway No. : 235
    tot-CaM-CaMKII-PSD
  • CaMKII-thr286-Ca
    M-PSD

    CaMKII-CaM-PSD

  • CaMKII-CaM-PSD acting as a Substrate for an Enzyme in  
    AMPAR_traff_model0 Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1tot-auto-PSD  /
    auton-286-PSD
  • AMPAR_traff_
    model0

    Accession No. : 59
  • CaMKII
    Pathway No. : 235
    125.0010.54explicit E-S complexSubstrate
    CaMKII-CaM-PSD

    Product
  • CaMKII-thr286-Ca
    M-PSD

  • 2
  • tot-CaM-CaMKII-P
    SD
      /
    CaM-act-286-PSD
  • AMPAR_traff_
    model0

    Accession No. : 59
  • CaMKII
    Pathway No. : 235
    81.16940.54explicit E-S complexSubstrate
    CaMKII-CaM-PSD

    Product
  • CaMKII-thr286-Ca
    M-PSD


  • CaMKII-CaM-PSD acting as a Product of an Enzyme in  
    AMPAR_traff_model0 Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PP1-active_PSD  /
    Deph-thr286
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PP1_PSD
    Pathway No. : 239
    1.999942.54explicit E-S complexSubstrate
  • CaMKII-thr286-Ca
    M-PSD


    Product
    CaMKII-CaM-PSD

  • CaMKII-CaM-PSD acting as a Substrate in a reaction in  
    AMPAR_traff_model0 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    CaMKII-diss-CaM
  • AMPAR_traff_
    model0

    Accession No. : 59
  • CaMKII
    Pathway No. : 235
    5
    (s^-1)
    0
    (uM^-1 s^-1)
    --Substrate
    CaMKII-CaM-PSD

    Product
    CaM-Ca4-PSD
    CaMKII-PSD

    CaMKII-CaM-PSD acting as a Product in a reaction in  
    AMPAR_traff_model0 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1transloc_1
  • AMPAR_traff_
    model0

    Accession No. : 59
  • CaMKII
    Pathway No. : 235
    0
    (#^-1 s^-1)
    0
    (s^-1)
    Not applicable**-Substrate
    CaMKII-CaM
    NMDAR

    Product
    CaMKII-CaM-PSD
      Rates to match curve in fig2 from Shen and Meyer, Science 284:162-166(1999), calculated for 6:1 alpha:beta CaMKII heterodimers
    2
  • CaMKII-bind-CaM-
    PSD
  • AMPAR_traff_
    model0

    Accession No. : 59
  • CaMKII
    Pathway No. : 235
    49.9998
    (uM^-1 s^-1)
    0
    (s^-1)
    --Substrate
    CaM-Ca4-PSD
    CaMKII-PSD

    Product
    CaMKII-CaM-PSD



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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