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Molecule Parameter List for MAPKK*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
MAPKK* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1021100

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig4_synapse3Network
Shared_Object_fig4_synapse PKC PLA2 
PLCbeta Gq MAPK 
Ras CaMKII CaM 
PP1 PP2B PKA 
AC 
This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper.
Demonstration script files for generating the figures in the paper, including figure 4, are available here.

MAPKK* acting as a Molecule in  
fig4_synapse Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
MAPKK*fig4_synapse
Accession No. : 3
MAPK
Pathway No. : 24
01000No

MAPKK* acting as an Enzyme in  
fig4_synapse Network
 Enzyme Molecule /
Enzyme Activity
Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
1MAPKK* /
MAPKKtyr
fig4_synapse
Accession No. : 3
MAPK
Pathway No. : 24
0.04629630.154explicit E-S complexSubstrate
MAPK

Product
MAPK-tyr
2MAPKK* /
MAPKKthr
fig4_synapse
Accession No. : 3
MAPK
Pathway No. : 24
0.04629630.154explicit E-S complexSubstrate
MAPK-tyr

Product
MAPK*

MAPKK* acting as a Substrate for an Enzyme in  
fig4_synapse Network
Enzyme Molecule /
Enzyme Activity
Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
PPhosphatase2A  /
MAPKK-deph
fig4_synapse
Accession No. : 3
  • Shared_Object_
    fig4_synapse

    Pathway No. : 19
  • 15.656664.16667explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser

    MAPKK* acting as a Product of an Enzyme in  
    fig4_synapse Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    Raf-GTP-Ras*  /
    Raf-GTP-Ras*.2
    fig4_synapse
    Accession No. : 3
    MAPK
    Pathway No. : 24
    0.1590910.1054explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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