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Molecule Parameter List for CaMKII

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaMKII participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1110211

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • AMPAR_traff_
    model1
  • 60Network
    Shared_Object_AMPAR_traff_model1 CaMKII CaM 
    PP1 PP2B PP1_PSD 
    PKA AC AMPAR 
    AMPAR_memb 
    This is the basic model of AMPAR trafficking bistability. It is based on Hayer and Bhalla, PLoS Comput. Biol. 2005. It includes the degradation and turnover of AMPARs. The CaMKII portion of the model is not bistable.

    CaMKII acting as a Molecule in  
    AMPAR_traff_model1 Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    CaMKII
  • AMPAR_traff_
    model1

    Accession No. : 60
  • CaMKII
    Pathway No. : 245
    200.09No
    Huge conc of CaMKII. In PSD it is 20-40% of protein, so we assume it is around 2.5% of protein in spine as a whole. This level is so high it is unlikely to matter much if we are off a bit. This comes to about 70 uM.

    CaMKII acting as a Summed Molecule in  
    AMPAR_traff_model1 Network
    Accession NamePathway NameTargetInput
  • AMPAR_traff_
    model1

    Accession No. : 60
  • CaMKII
    Pathway No. : 245
    tot_CaMKII_cytCaMKII-CaM
  • CaMKII-thr286*-C
    aM

    CaMKII-thr286
    CaMKII***
    CaMK-thr305
    CaMKII
  • basal_CaMKII_
    cyt


  • CaMKII acting as an Enzyme in  
    AMPAR_traff_model1 Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    actCaMKII-PSD /
    CaMKII
  • AMPAR_traff_
    model1

    Accession No. : 60
  • CaMKII
    Pathway No. : 245
    90.00060.54explicit E-S complexSubstrate
    A845*_B845*

    Product
    A831*845*_B845*

    CaMKII acting as a Product of an Enzyme in  
    AMPAR_traff_model1 Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1PP1-active  /
    Deph-thr286b
  • AMPAR_traff_
    model1

    Accession No. : 60
  • PP1
    Pathway No. : 247
    5.099052.54explicit E-S complexSubstrate
    CaMKII-thr286

    Product
    CaMKII
    2PP1-active  /
    Deph-thr305a
  • AMPAR_traff_
    model1

    Accession No. : 60
  • PP1
    Pathway No. : 247
    5.099052.54explicit E-S complexSubstrate
    CaMK-thr305

    Product
    CaMKII

    CaMKII acting as a Substrate in a reaction in  
    AMPAR_traff_model1 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    CaMKII-bind-CaM
  • AMPAR_traff_
    model1

    Accession No. : 60
  • CaMKII
    Pathway No. : 245
    49.9997
    (uM^-1 s^-1)
    5
    (s^-1)
    Kd(bf) = 0.1(uM)-Substrate
    CaM-Ca4
    CaMKII

    Product
    CaMKII-CaM
    This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol.

    CaMKII acting as a Product in a reaction in  
    AMPAR_traff_model1 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    back_1
  • AMPAR_traff_
    model1

    Accession No. : 60
  • CaMKII
    Pathway No. : 245
    0.3
    (s^-1)
    0
    (#^-1 s^-1)
    Not applicable**-Substrate
    CaMKII-PSD

    Product
    CaMKII
    NMDAR
    Rates set by the translocation experiments of Shen and Meyer, Science 1999.
    ** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration



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