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Molecule Parameter List for PP1-I1* | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | AMPAR_traff_
model1 | 60 | Network |
Shared_Object_AMPAR_traff_model1, CaMKII, CaM,
PP1, PP2B, PP1_PSD,
PKA, AC, AMPAR,
AMPAR_memb | | This is the basic model of AMPAR trafficking bistability. It is based on Hayer and Bhalla, PLoS Comput. Biol. 2005. It includes the degradation and turnover of AMPARs. The CaMKII portion of the model is not bistable. |
PP1-I1* acting as a Molecule in AMPAR_traff_model1 Network
PP1-I1* acting as a Substrate for an Enzyme in AMPAR_traff_model1 Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | PP2A /
PP2A-dephosph-PP
1-I*
| AMPAR_traff_
model1
Accession No. : 60 | PP1
Pathway No. : 247 | 15.9999 | 2 | 4.1667 | explicit E-S complex | Substrate
PP1-I1*
Product
PP1-I1
| | | k1 changed from 3.3e-6 to 6.6e-6 | | 2 | PP2A /
PP2A-dephosph-PP
1-I*_
PSD
| AMPAR_traff_
model1
Accession No. : 60 | PP1
Pathway No. : 247 | 15.9999 | 2 | 4.1667 | explicit E-S complex | Substrate
PP1-I1*
Product
PP1-I1
| | | k1 changed from 3.3e-6 to 6.6e-6 | | 3 | CaM_Ca_n-CaNAB /
dephosph-PP1-I* | AMPAR_traff_
model1
Accession No. : 60 | PP2B
Pathway No. : 248 | 4.97079 | 0.34 | 4 | explicit E-S complex | Substrate
PP1-I1*
Product
PP1-I1
| | 4 | CaM_Ca_n-CaNAB /
dephosph-PP1-I*_
PSD
| AMPAR_traff_
model1
Accession No. : 60 | PP2B
Pathway No. : 248 | 4.97071 | 0.34 | 4 | explicit E-S complex | Substrate
PP1-I1*
Product
PP1-I1
|
PP1-I1* acting as a Product in a reaction in AMPAR_traff_model1 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | Inact-PP1 | AMPAR_traff_
model1
Accession No. : 60 | PP1
Pathway No. : 247 | 499.981
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0002(uM) | - | Substrate
I1*
PP1-active
Product
PP1-I1*
| | | K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4 | | 2 | Inact-PP1 | AMPAR_traff_
model1
Accession No. : 60 | PP1_PSD
Pathway No. : 249 | 499.98
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0002(uM) | - | Substrate
I1*
PP1-active_PSD
Product
PP1-I1*
| | | K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4 |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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