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Molecule Parameter List for PP2A | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| PP2A participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 0 | 4 | 0 | 0 | 0 | 0 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | AMPAR_traff_
model1 | 60 | Network |
Shared_Object_AMPAR_traff_model1, CaMKII, CaM,
PP1, PP2B, PP1_PSD,
PKA, AC, AMPAR,
AMPAR_memb | | This is the basic model of AMPAR trafficking bistability. It is based on Hayer and Bhalla, PLoS Comput. Biol. 2005. It includes the degradation and turnover of AMPARs. The CaMKII portion of the model is not bistable. |
PP2A acting as a Molecule in AMPAR_traff_model1 Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | PP2A | AMPAR_traff_
model1
Accession No. : 60 | PP1
Pathway No. : 247 | 0.1111 | 0.09 | No | | |
PP2A acting as an Enzyme in AMPAR_traff_model1 Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | PP2A /
PP2A-dephosph-I1
| AMPAR_traff_
model1
Accession No. : 60 | PP1
Pathway No. : 247 | 15.9999 | 2 | 4.1667 | explicit E-S complex | Substrate
I1*
Product
I1
| | | PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6 | | 2 | PP2A /
PP2A-dephosph-PP
1-I*
| AMPAR_traff_
model1
Accession No. : 60 | PP1
Pathway No. : 247 | 15.9999 | 2 | 4.1667 | explicit E-S complex | Substrate
PP1-I1*
Product
PP1-I1
| | | k1 changed from 3.3e-6 to 6.6e-6 | | 3 | PP2A /
PP2A-dephosph-I1
_
PSD
| AMPAR_traff_
model1
Accession No. : 60 | PP1
Pathway No. : 247 | 15.9999 | 2 | 4.1667 | explicit E-S complex | Substrate
I1*
Product
I1
| | | PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6 | | 4 | PP2A /
PP2A-dephosph-PP
1-I*_
PSD
| AMPAR_traff_
model1
Accession No. : 60 | PP1
Pathway No. : 247 | 15.9999 | 2 | 4.1667 | explicit E-S complex | Substrate
PP1-I1*
Product
PP1-I1
| | | k1 changed from 3.3e-6 to 6.6e-6 |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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