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Molecule Parameter List for PP1-active

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PP1-active participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1050011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • AMPAR_traff_
    model1
  • 60Network
    Shared_Object_AMPAR_traff_model1 CaMKII CaM 
    PP1 PP2B PP1_PSD 
    PKA AC AMPAR 
    AMPAR_memb 
    This is the basic model of AMPAR trafficking bistability. It is based on Hayer and Bhalla, PLoS Comput. Biol. 2005. It includes the degradation and turnover of AMPARs. The CaMKII portion of the model is not bistable.

    PP1-active acting as a Molecule in  
    AMPAR_traff_model1 Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    PP1-active
  • AMPAR_traff_
    model1

    Accession No. : 60
  • PP1
    Pathway No. : 247
    1.80.09No
    Cohen et al Meth Enz 159 390-408 is main source of info conc = 1.8 uM

    PP1-active acting as an Enzyme in  
    AMPAR_traff_model1 Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1PP1-active /
    Deph-thr286
  • AMPAR_traff_
    model1

    Accession No. : 60
  • PP1
    Pathway No. : 247
    5.099052.54explicit E-S complexSubstrate
  • CaMKII-thr286*-C
    aM


    Product
    CaMKII-CaM
  • 2PP1-active /
    Deph-thr286b
  • AMPAR_traff_
    model1

    Accession No. : 60
  • PP1
    Pathway No. : 247
    5.099052.54explicit E-S complexSubstrate
    CaMKII-thr286

    Product
    CaMKII
    3PP1-active /
    Deph-thr305
  • AMPAR_traff_
    model1

    Accession No. : 60
  • PP1
    Pathway No. : 247
    5.099052.54explicit E-S complexSubstrate
    CaMKII***

    Product
    CaMKII-thr286
    4PP1-active /
    Deph-thr286c
  • AMPAR_traff_
    model1

    Accession No. : 60
  • PP1
    Pathway No. : 247
    5.099052.54explicit E-S complexSubstrate
    CaMKII***

    Product
    CaMK-thr305
    5PP1-active /
    Deph-thr305a
  • AMPAR_traff_
    model1

    Accession No. : 60
  • PP1
    Pathway No. : 247
    5.099052.54explicit E-S complexSubstrate
    CaMK-thr305

    Product
    CaMKII

    PP1-active acting as a Substrate in a reaction in  
    AMPAR_traff_model1 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    Inact-PP1
  • AMPAR_traff_
    model1

    Accession No. : 60
  • PP1
    Pathway No. : 247
    499.981
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 0.0002(uM)-Substrate
    I1*
    PP1-active

    Product
    PP1-I1*
    K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4

    PP1-active acting as a Product in a reaction in  
    AMPAR_traff_model1 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    dissoc-PP1-I1
  • AMPAR_traff_
    model1

    Accession No. : 60
  • PP1
    Pathway No. : 247
    1
    (s^-1)
    0
    (uM^-1 s^-1)
    --Substrate
    PP1-I1

    Product
    I1
    PP1-active
    Let us assume that the equil in this case is very far over to the right. This is probably safe.



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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